ΣΥΧΝΕΣ ΕΡΩΤΗΣΕΙΣ
1. PDQ® Integrative, Alternative, and Complementary Therapies Editorial Board. PDQ Medicinal Mushrooms. Bethesda, MD: National Cancer Institute. Updated July 11, 2024. Available at: https://www.cancer.gov/about-cancer/treatment/cam/patient/mushrooms-pdq. Accessed 30/12/2025. [PMID: 28267306]
2. Łysakowska P, Sobota A, Wirkijowska A. Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review. Molecules. 2023 Jul 14;28(14):5393. doi: 10.3390/molecules28145393. PMID: 37513265; PMCID: PMC10384337.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10384337/
3. Venturella G, Ferraro V, Cirlincione F, Gargano ML. Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials. Int J Mol Sci. 2021 Jan 10;22(2):634. doi: 10.3390/ijms22020634. PMID: 33435246; PMCID: PMC7826851.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7826851/
4. Aaron Katz, Chapter 11 - Alternative Medicine for Prostate Cancer: Diet, Vitamins, Minerals, and Supplements, Editor(s): Li-Ming Su, Early Diagnosis and Treatment of Cancer Series: Prostate Cancer, W.B. Saunders, 2010, Pages 207-228, ISBN 9781416045755, https://doi.org/10.1016/B978-1-4160-4575-5.50017-7.
https://www.sciencedirect.com/science/article/abs/pii/B9781416045755500177
5. Aviva Romm, CHAPTER 10 - Breast Cancer, Editor(s): Aviva Romm, Mary L. Hardy, Simon Mills, Botanical Medicine for Women's Health, Churchill Livingstone, 2010, Pages 306-320, ISBN 9780443072772, https://doi.org/10.1016/B978-0-443-07277-2.00012-X.
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/medicinal-mushroom
6. W.G. Jiang, A.J. Sanders, M. Katoh, H. Ungefroren, F. Gieseler, M. Prince, S.K. Thompson, M. Zollo, D. Spano, P. Dhawan, D. Sliva, P.R. Subbarayan, M. Sarkar, K. Honoki, H. Fujii, A.G. Georgakilas, A. Amedei, E. Niccolai, A. Amin, S.S. Ashraf, L. Ye, W.G. Helferich, X. Yang, C.S. Boosani, G. Guha, M.R. Ciriolo, K. Aquilano, S. Chen, A.S. Azmi, W.N. Keith, A. Bilsland, D. Bhakta, D. Halicka, S. Nowsheen, F. Pantano, D. Santini, Tissue invasion and metastasis: Molecular, biological and clinical perspectives, Seminars in Cancer Biology, Volume 35, Supplement, 2015, Pages S244-S275, ISSN 1044-579X, https://doi.org/10.1016/j.semcancer.2015.03.008.
https://www.sciencedirect.com/science/article/pii/S1044579X15000231
7. Venturella G, Ferraro V, Cirlincione F, Gargano ML. Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials. Int J Mol Sci. 2021 Jan 10;22(2):634. doi: 10.3390/ijms22020634. PMID: 33435246; PMCID: PMC7826851.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7826851/
8. Łysakowska P, Sobota A, Wirkijowska A. Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review. Molecules. 2023 Jul 14;28(14):5393. doi: 10.3390/molecules28145393. PMID: 37513265; PMCID: PMC10384337.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10384337/
9. Lam CS, Cheng LP, Zhou LM, Cheung YT, Zuo Z. Herb-drug interactions between the medicinal mushrooms Lingzhi and Yunzhi and cytotoxic anticancer drugs: a systematic review. Chin Med. 2020 Jul 25;15:75. doi: 10.1186/s13020-020-00356-4. PMID: 32724333; PMCID: PMC7382813.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7382813/
10. Łysakowska P, Sobota A, Wirkijowska A. Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review. Molecules. 2023 Jul 14;28(14):5393. doi: 10.3390/molecules28145393. PMID: 37513265; PMCID: PMC10384337.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10384337/
11. WebMD, Reishi Mushroom - Uses, Side Effects, and More
https://www.webmd.com/vitamins/ai/ingredientmono-905/reishi-mushroom
12. Economically Motivated Adulteration (Food Fraud), FDA
https://www.fda.gov/food/compliance-enforcement-food/economically-motivated-adulteration-food-fraud
13. Sujogya Kumar Panda, Walter Luyten, Medicinal mushrooms: Clinical perspective and challenges, Drug Discovery Today, Volume 27, Issue 2, 2022, Pages 636-651, ISSN 1359-6446, https://doi.org/10.1016/j.drudis.2021.11.017.
https://www.sciencedirect.com/science/article/abs/pii/S1359644621004980
14. Medicinal Mushroom Market Research Report Information By Type (Reishi, Maitake, Shiitake, Chaga, Cordyceps, Turkey Tail, and Other Types), By Form (Fresh, Dried, and Other Form), By Function (Antioxidant, Immune Enhancer, Anti-Cancer, Skin Care, and Other Functions) And By Region (North America, Europe, Asia-Pacific, And Rest Of The World) –Market Forecast Till 2034
https://www.marketresearchfuture.com/reports/medicinal-mushroom-market-5556
15. La Monica MB, Raub B, Ziegenfuss EJ, Hartshorn S, Grdic J, Gustat A, Sandrock J, Ziegenfuss TN. Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion's Mane Extracts on Cognitive Performance. Nutrients. 2023 Dec 6;15(24):5018. doi: 10.3390/nu15245018. PMID: 38140277; PMCID: PMC10745489.
https://pubmed.ncbi.nlm.nih.gov/38140277/
https://www.mdpi.com/2072-6643/15/24/5018
16. What Are Adaptogenic Mushrooms? Benefits, Risks, and Types, Medically reviewed by Kim Chin, RD, Nutrition — Written by Jillian Kubala, MS, RD on March 19, 2021
https://www.healthline.com/nutrition/adaptogenic-mushrooms#safety
17. Łysakowska P, Sobota A, Wirkijowska A. Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review. Molecules. 2023 Jul 14;28(14):5393. doi: 10.3390/molecules28145393. PMID: 37513265; PMCID: PMC10384337.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10384337/
18. Magic Mushrooms, Government of Alberta, June 1, 2023
https://myhealth.alberta.ca/alberta/pages/what-are-magic-mushrooms.aspx
19. Psilocybin (Magic Mushrooms), January 2024, NIH
https://nida.nih.gov/research-topics/psilocybin-magic-mushrooms
20. What Are "Magic" Mushrooms? March 2023, Nemours® KidsHealth
https://kidshealth.org/en/parents/mushrooms.html
21. Gariboldi MB, Marras E, Ferrario N, Vivona V, Prini P, Vignati F, Perletti G. Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer. Int J Mol Sci. 2023 Jun 14;24(12):10120. doi: 10.3390/ijms241210120. PMID: 37373268; PMCID: PMC10299416.
https://pubmed.ncbi.nlm.nih.gov/37373268/
22. Chang S, Buswell J. Medicinal Mushrooms: Past, Present and Future. Adv Biochem Eng Biotechnol. 2023;184:1-27. doi: 10.1007/10_2021_197. PMID: 35220455.
https://pubmed.ncbi.nlm.nih.gov/35220455/
23. Hetland G, Johnson E, Bernardshaw SV, Grinde B. Can medicinal mushrooms have prophylactic or therapeutic effect against COVID-19 and its pneumonic superinfection and complicating inflammation? Scand J Immunol. 2021 Jan;93(1):e12937. doi: 10.1111/sji.12937. Epub 2020 Jul 29. PMID: 32657436; PMCID: PMC7404338.
https://pubmed.ncbi.nlm.nih.gov/32657436/
24. Sharma D, Singh VP, Singh NK. A Review on Phytochemistry and Pharmacology of Medicinal as well as Poisonous Mushrooms. Mini Rev Med Chem. 2018;18(13):1095-1109. doi: 10.2174/1389557517666170927144119. PMID: 28971768.
https://pubmed.ncbi.nlm.nih.gov/28971768/
25. Islam T, Ganesan K, Xu B. New Insight into Mycochemical Profiles and Antioxidant Potential of Edible and Medicinal Mushrooms: A Review. Int J Med Mushrooms. 2019;21(3):237-251. doi: 10.1615/IntJMedMushrooms.2019030079. PMID: 31002608.
https://pubmed.ncbi.nlm.nih.gov/31002608/
26. Lo HC. Bioactive Components and Possible Activities of Medicinal Mushrooms in Alleviating the Pathogenesis of Nonalcoholic Fatty Liver Disease (Review). Int J Med Mushrooms. 2021;23(3):29-41. doi: 10.1615/IntJMedMushrooms.2021037945. PMID: 33822497.
https://pubmed.ncbi.nlm.nih.gov/33822497/
27. Can You Eat Mushrooms During Pregnancy? Medically reviewed by Lisa Hodgson, RDN, CDN, CDCES, FADCES, Nutrition — Written by Amber Charles Alexis, MSPH, RDN on November 3, 2021, Healthline Media LLC
https://www.healthline.com/nutrition/can-pregnant-women-eat-mushrooms#nutrition
28. Medicinal Mushrooms Before, During, and After Pregnancy - Safety, and What Works Updated: Sep 5, 2023, Anna Sitkoff
https://www.drannasitkoff.com/post/mushroom-safety-effectiveness-pregnancy
29. Mushrooms - A Pregnancy Superfood April 15, 2024, Cincinnati Birth Center
https://www.cincinnatibirthcenter.com/blog/mushrooms-a-pregnancy-superfood
30. Sun L, Niu Z. A mushroom diet reduced the risk of pregnancy-induced hypertension and macrosomia: a randomized clinical trial. Food Nutr Res. 2020 Jun 8;64. doi: 10.29219/fnr.v64.4451. PMID: 32577117; PMCID: PMC7286351.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7286351/
31. Remedia Homeopathy - homeopathic remedies manufactory
https://remedia-homeopathy.com/about-us/
32. Ganoderma lucidum, Remedia Homeopathy
https://remedia-homeopathy.com/shop/ganoderma-lucidum/a9051134
33. Resurrection of the Vital Force: Blockages to Healing in Homeopathy By Dr Paul Anderson Theriault, BSc, ND, VNMI
https://www.lulu.com/shop/dr-paul-anderson-theriault-bsc-nd-vnmi/resurrection-of-the-vital-force-blockages-to-healing-in-homeopathy/paperback/product-1kkk77r4.html?page=1&pageSize=4
34. Arul V, Kandasamy R, SP M. Antioxidant and cytotoxic potential of potentized preparation of Cordyceps sinensis in vitro in cancer cell lines. Indian J Res Homoeopathy 2023;17. doi: 10.53945/2320-7094.1131
https://www.ijrh.org/journal/vol17/iss1/2/
35. Medicinal Mushrooms and their history of therapeutic uses for emotional and physical wellbeing in children and adults 30 Oct 2024 5:00pm to 6:30pm Conferences, CPD Resource, Education, Latest News, Webinars
https://www.facultyofhomeopathy.org/events/medicinal-mushrooms-their-history-of-therapeutic-uses
36. Gøtzsche PC. Our prescription drugs kill us in large numbers. Pol Arch Med Wewn. 2014;124(11):628-34. doi: 10.20452/pamw.2503. Epub 2014 Oct 30. PMID: 25355584.
https://pubmed.ncbi.nlm.nih.gov/25355584/
37. Peter C Gøtzsche: Prescription drugs are the third leading cause of death June 16, 2016
https://blogs.bmj.com/bmj/2016/06/16/peter-c-gotzsche-prescription-drugs-are-the-third-leading-cause-of-death/
38. Prescription Drugs Are the Leading Cause of Death And psychiatric drugs are the third leading cause of death By Peter C. Gøtzsche, MD - April 16, 2024
https://www.madinamerica.com/2024/04/prescription-drugs-are-the-leading-cause-of-death/
39. ΠΡΟΓΡΑΜΜΑ ΜΑΘΗΜΑΤΩΝ ΣΕΜΙΝΑΡΙΩΝ ΒΡΑΧΕΙΑΣ ΕΚΠΑΙΔΕΥΣΗΣ «ΤΡΙΠΤΟΛΕΜΟΣ» Κατεύθυνση: «Εδώδιμα Μανιτάρια: Καλλιέργεια – Αξιοποίηση». Χρηματοδοτείται από την Γενική Γραμματεία Δια Βίου Μάθησης και Νέας Γενιάς (Διεύθυνση Νέας Γενιάς)
https://www.minedu.gov.gr/publications/docs2016/250416_programms-endodima-manitaria.pdf
40. ΥΠΟΥΡΓΕΙΟ ΑΓΡΟΤΙΚΗΣ ΑΝΑΠΤΥΞΗΣ - ΜΑΝΙΤΑΡΙΑ
https://www.minagric.gr/images/stories/docs/agrotis/Aromatika_Fyta/Manitari_entypo_291211.pdf
41. Breene WM. Nutritional and Medicinal Value of Specialty Mushrooms. J Food Prot. 1990 Oct;53(10):883-894. doi: 10.4315/0362-028X-53.10.883. PMID: 31018285.
https://pubmed.ncbi.nlm.nih.gov/31018285/
42. Chang ST, Buswell JA. Mushroom nutriceuticals. World J Microbiol Biotechnol. 1996 Sep;12(5):473-6. doi: 10.1007/BF00419460. PMID: 24415377.
https://pubmed.ncbi.nlm.nih.gov/24415377/
43. Cao Y, Xu X, Liu S, Huang L, Gu J. Ganoderma: A Cancer Immunotherapy Review. Front Pharmacol. 2018 Oct 25;9:1217. doi: 10.3389/fphar.2018.01217. PMID: 30410443; PMCID: PMC6209820.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6209820/
44. 26 Ιανουαρίου 2019 | 19:12 Καλλιέργεια φαρμακευτικών μανιταριών από το ΤΕΙ Θεσσαλίας, in.gr
https://www.in.gr/2019/01/26/health/health-news/kalliergeia-farmakeytikon-manitarion-apo-tei-thessalias/
45. Ινστιτούτο Τεχνολογίας Γεωργικών Προϊόντων (I.ΤΕ.ΓΕ.Π)
https://itap.com.gr/edodimon-mykiton-2/
46. Ροηλίδη, Αθανασία, Ανίχνευση πιθανής πρεβιοτικής δράσης σε μύκητες του γένους Ganoderma, 2016,
https://estia.hua.gr/browse/17261
47. Εθνικό Μετσόβιο Πολυτεχνείο, Σχολή Χημικών Μηχανικών, Απομόνωση και αξιολόγηση πρωτεϊνικών και υδατανθρακικών συστατικών μανιταριών, Διπλωματική Εργασία, Τσαλτάκη Χρυσούλα
https://dspace.lib.ntua.gr/xmlui/bitstream/handle/123456789/43369/%CE%B4%CE%B9%CF%80%CE%BB%CF%89%CE%BC%CE%B1%CF%84%CE%B9%CE%BA%CE%AE%20%CE%B5%CF%81%CE%B3%CE%B1%CF%83%CE%AF%CE%B1%20-%20%CE%A4%CF%83%CE%B1%CE%BB%CF%84%CE%AC%CE%BA%CE%B7%20%CE%A7%CF%81%CF%85%CF%83%CE%BF%CF%8D%CE%BB%CE%B1.pdf?sequence=1&isAllowed=y
48. ΑΤΕΙ Καλαμάτας, Τμήμα ΤΕΓΕΠ, Πτυχιακή Εργασία, Φαρμακευτικές ιδιότητες βασιδιομυκήτων και ασκομυκήτων, Δημητριάδου Ελένη,
http://nestor.teipel.gr/xmlui/bitstream/handle/123456789/14673/STEG_TEGEP_00495_Medium.pdf?sequence=1
49. Πανεπιστήμιο Αιγαίου, Τμήμα Επιστήμης Τροφίμων και Διατροφής, Πτυχιακή Εργασία, Ο ρόλος της διατροφής στην πρόληψη του καρκίνου, Καρυωτάκη Στυλιανή,
https://hellanicus.lib.aegean.gr/bitstream/handle/11610/18640/%CE%9A%CE%B1%CF%81%CF%85%CF%89%CF%84%CE%AC%CE%BA%CE%B7%20%CE%A3%CF%84%CE%AD%CE%BB%CE%BB%CE%B1-%CE%A0%CF%84%CF%85%CF%87%CE%B1%CE%BA%CE%AE.pdf?sequence=1&isAllowed=y
50. Χαροκόπειο Πανεπιστήμιο, Ανίχνευση πιθανής πρεβιοτικής δράσης σε βασιδιομύκητες. Πτυχιακή εργασία, Σεκκίδου, Μικαέλα
https://www.openarchives.gr/aggregator-openarchives/edm/estia/000015-15662/view
51. Γεωπονικό Πανεπιστήμιο Αθηνών, Μεταπτυχιακή εργασία, Μελέτη της βιοδραστικότητας εκχυλισμάτων μυκηλίου και καρποσωμάτων μυκήτων του γένους Ganoderma, Ευσταθιάδου Ευδοξία
https://www.openarchives.gr/aggregator-openarchives/edm/aua/000039-10329_6463
52. ΑΤΕΙ Καλαμάτας, Τμήμα Θερμοκηπειακής Καλλιέργειας και Ανθοκομίας, Πτυχιακή Εργασία, Φαρμακευτικά μανιτάρια ως διαιτητικά συμπληρώματα διατροφής, Μαργαρίτα Μαρδίτσα
http://nestor.teipel.gr/xmlui/bitstream/handle/123456789/13599/STEG_THEKA_00515_Medium.pdf?sequence=1
53. Πανεπιστήμιο Θεσσαλίας Τμήμα Ιατρικής Μεταπτυχιακό Πρόγραμμα Σπουδών “Εφαρμοσμένη Δημόσια Υγεία και Περιβαλλοντική Υγιεινή: Ποιότητα- Ασφάλεια Τροφίμων & Υδάτων, Δημόσια Υγεία”, Διπλωματική Εργασία “ H Βιολογική δραστικότητα του βασιδιομύκητα Ganoderma lucidum και η συμβολή του στην προαγωγή της υγείας.” Χονδρού Αικατερίνη του Ιωάννη, 2015
https://ir.lib.uth.gr/xmlui/bitstream/handle/11615/44704/13655.pdf?sequence=1&isAllowed=y
54. ΤΜΗΜΑ ΕΠΙΣΤΗΜΗΣ ΚΑΙ ΤΕΧΝΟΛΟΓΙΑΣ ΤΡΟΦΙΜΩΝ ΠΑΝΕΠΙΣΤΗΜΙΟ ΔΥΤΙΚΗΣ ΑΤΤΙΚΗΣ, ΠΤΥΧΙΑΚΗ ΕΡΓΑΣΙΑ, ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΙΔΙΟΤΗΤΕΣ ΜΑΝΙΤΑΡΙΩΝ ΚΑΙ ΟΙ ΒΙΟΔΡΑΣΤΙΚΕΣ ΤΟΥΣ ΟΥΣΙΕΣ, Μιχοπούλου Αγγελική (Α.Μ 71614537), Ψυχογιού Μαρία (Α.Μ 71614411) Επιβλέπουσα καθηγήτρια : Στεφάνου Βαλεντίνα Αθήνα, 2021
https://polynoe.lib.uniwa.gr/xmlui/bitstream/handle/11400/1361/Michopoulou_71614537.pdf.pdf?sequence=1&isAllowed=y
55. Ταβουλτσίδη, Αικατερίνη Αγγελική, 2015, Επεξεργασία εδώδιμων μανιταριών βασιδιομυκήτων και ασκομυκήτων, Προπτυχιακή/Διπλωματική εργασία, ΤΕΙ Πελοποννησου, Τμήμα Τεχνολογίας Γεωργικών Προϊόντων (ΤΕ.ΓΕ.Π.)
http://nestor.teipel.gr/xmlui/handle/123456789/14537?show=full
56. Πάππα, Στυλιανή (2006) Τα είδη μανιταριών και η παραγωγή, αξιοποίηση και διατροφική τους αξία. BSc thesis, ΤΕΙ Δυτικής Μακεδονίας. Σχολή Τεχν.Γεωπονίας και Τεχν.Τροφίμων και Διατροφής > Τμήμα Εμπορίας και Ποιοτικού Ελέγχου Αγροτικών Προϊόντων (Φλώρινα)
https://anaktisis.uowm.gr/626/
57. Παναγιώτου, Αλεξάνδρα, Φώτιος, Επίδραση του εντερικού μικροβιόκοσμου στον οστικό μεταβολισμό, 2019,
https://estia.hua.gr/browse/21441
58. Extra Virgin Olive Oil Market Research Report Information By Category (Organic and Conventional), By Packaging (Bottles & Jars, Cans, and Others), By Distribution Channel (Store-Based, and Non-Store-Based) And By Region (North America, Europe, Asia-Pacific, And Rest Of The World) –Market Forecast Till 2032
https://www.marketresearchfuture.com/reports/extra-virgin-olive-oil-market-4124
59. Panda SK, Luyten W. Medicinal mushrooms: Clinical perspective and challenges. Drug Discov Today. 2022 Feb;27(2):636-651. doi: 10.1016/j.drudis.2021.11.017. Epub 2021 Nov 22. PMID: 34823005.
https://pubmed.ncbi.nlm.nih.gov/34823005/
60. Motta F, Gershwin ME, Selmi C. Mushrooms and immunity. J Autoimmun. 2021 Feb;117:102576. doi: 10.1016/j.jaut.2020.102576. Epub 2020 Dec 1. PMID: 33276307.
https://pubmed.ncbi.nlm.nih.gov/33276307/
61. Jeitler M, Michalsen A, Frings D, Hübner M, Fischer M, Koppold-Liebscher DA, Murthy V, Kessler CS. Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review. Front Pharmacol. 2020 Nov 11;11:580656. doi: 10.3389/fphar.2020.580656. PMID: 33424591; PMCID: PMC7794004.
https://pubmed.ncbi.nlm.nih.gov/33424591/
62. Dan A, Swain R, Belonce S, Jacobs RJ. Therapeutic Effects of Medicinal Mushrooms on Gastric, Breast, and Colorectal Cancer: A Scoping Review. Cureus. 2023 Apr 14;15(4):e37574. doi: 10.7759/cureus.37574. PMID: 37193480; PMCID: PMC10183216.
https://pubmed.ncbi.nlm.nih.gov/37193480/
63. Phan CW, David P, Sabaratnam V. Edible and Medicinal Mushrooms: Emerging Brain Food for the Mitigation of Neurodegenerative Diseases. J Med Food. 2017 Jan;20(1):1-10. doi: 10.1089/jmf.2016.3740. PMID: 28098514.
https://pubmed.ncbi.nlm.nih.gov/28098514/
64. Zhao S, Gao Q, Rong C, Wang S, Zhao Z, Liu Y, Xu J. Immunomodulatory Effects of Edible and Medicinal Mushrooms and Their Bioactive Immunoregulatory Products. J Fungi (Basel). 2020 Nov 8;6(4):269. doi: 10.3390/jof6040269. PMID: 33171663; PMCID: PMC7712035.
https://pubmed.ncbi.nlm.nih.gov/33171663/
65. Drzewiecka, B.; Wessely-Szponder, J.; Świeca, M.; Espinal, P.; Fusté, E.; Fernández-De La Cruz, E. Bioactive Peptides and Other Immunomodulators of Mushroom Origin. Biomedicines 2024, 12, 1483.
https://www.mdpi.com/2227-9059/12/7/1483
66. Hetland G, Tangen JM, Mahmood F, Mirlashari MR, Nissen-Meyer LSH, Nentwich I, Therkelsen SP, Tjønnfjord GE, Johnson E. Antitumor, Anti-Inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifolafrondosa: A Review of Preclinical and Clinical Studies. Nutrients. 2020 May 8;12(5):1339. doi: 10.3390/nu12051339. PMID: 32397163; PMCID: PMC7285126.
https://pubmed.ncbi.nlm.nih.gov/32397163/
67. Manash Pratim Pathak, Kalyani Pathak, Riya Saikia, Urvashee Gogoi, Mohammad Zaki Ahmad, Pompy Patowary, Aparoop Das, Immunomodulatory effect of mushrooms and their bioactive compounds in cancer: A comprehensive review, Biomedicine & Pharmacotherapy, Volume 149, 2022, 112901, ISSN 0753-3322.
https://www.sciencedirect.com/science/article/pii/S0753332222002906
68. Akramiene D, Kondrotas A, Didziapetriene J, Kevelaitis E. Effects of beta-glucans on the immune system. Medicina (Kaunas). 2007;43(8):597-606. PMID: 17895634.
https://pubmed.ncbi.nlm.nih.gov/17895634/
69. Dong Y, Wang T, Zhao J, Gan B, Feng R, Miao R. Polysaccharides Derived from Mushrooms in Immune and Antitumor Activity: A Review. Int J Med Mushrooms. 2023;25(8):1-17. doi: 10.1615/IntJMedMushrooms.2023049062. PMID: 37560886.
https://pubmed.ncbi.nlm.nih.gov/37560886/
70. Vetvicka V, Vannucci L, Sima P, Richter J. Beta Glucan: Supplement or Drug? From Laboratory to Clinical Trials. Molecules. 2019 Mar 30;24(7):1251. doi: 10.3390/molecules24071251. PMID: 30935016; PMCID: PMC6479769.
https://pubmed.ncbi.nlm.nih.gov/30935016/
71. Do Mushroom Supplements Boost Immunity Against Cancer? By Susan Wagner Tuesday, October 22, 2024, Memorial Sloan Kettering Cancer Center
https://www.mskcc.org/news/do-mushroom-supplements-boost-immunity-against-cancer
72. Lull C, Wichers HJ, Savelkoul HF. Antiinflammatory and immunomodulating properties of fungal metabolites. Mediators Inflamm. 2005 Jun 9;2005(2):63-80. doi: 10.1155/MI.2005.63. PMID: 16030389; PMCID: PMC1160565.
https://pmc.ncbi.nlm.nih.gov/articles/PMC1160565/
73. Gründemann C, Reinhardt JK, Lindequist U. European medicinal mushrooms: Do they have potential for modern medicine? - An update. Phytomedicine. 2020 Jan;66:153131. doi: 10.1016/j.phymed.2019.153131. Epub 2019 Nov 2. PMID: 31790898.
https://pubmed.ncbi.nlm.nih.gov/31790898/
74. Rossi P, Difrancia R, Quagliariello V, Savino E, Tralongo P, Randazzo CL, Berretta M. B-glucans from Grifola frondosa and Ganoderma lucidum in breast cancer: an example of complementary and integrative medicine. Oncotarget. 2018 May 15;9(37):24837-24856. doi: 10.18632/oncotarget.24984. PMID: 29872510; PMCID: PMC5973856.
https://pubmed.ncbi.nlm.nih.gov/29872510/
75. Frost, Megan. “Three Popular Medicinal Mushroom Supplements: A Review of Human Clinical Trials.” (2016).
https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=2619&context=facpub
76. Naim MJ. A review on mushrooms as a versatile therapeutic agent with emphasis on its bioactive constituents for anticancer and antioxidant potential. Explor Med. 2024;5:312–30. https://doi.org/10.37349/emed.2024.00222
https://www.explorationpub.com/Journals/em/Article/1001222
77. Gafforov Y, Rašeta M, Rapior S, Yarasheva M, Wang X, Zhou L, Wan-Mohtar WAAQI, Zafar M, Lim YW, Wang M, Abdullaev B, Bussmann RW, Zengin G, Chen J. Macrofungi as Medicinal Resources in Uzbekistan: Biodiversity, Ethnomycology, and Ethnomedicinal Practices. J Fungi (Basel). 2023 Sep 13;9(9):922. doi: 10.3390/jof9090922. PMID: 37755030; PMCID: PMC10532728.
https://pubmed.ncbi.nlm.nih.gov/37755030/
78. Shamim MZ, Mishra AK, Kausar T, Mahanta S, Sarma B, Kumar V, Mishra PK, Panda J, Baek KH, Mohanta YK. Exploring Edible Mushrooms for Diabetes: Unveiling Their Role in Prevention and Treatment. Molecules. 2023 Mar 21;28(6):2837. doi: 10.3390/molecules28062837. PMID: 36985818; PMCID: PMC10058372.
https://pubmed.ncbi.nlm.nih.gov/36985818/
79. Tamrakar S, Tran HB, Nishida M, Kaifuchi S, Suhara H, Doi K, Fukami K, Parajuli GP, Shimizu K. Antioxidative activities of 62 wild mushrooms from Nepal and the phenolic profile of some selected species. J Nat Med. 2016 Oct;70(4):769-79. doi: 10.1007/s11418-016-1013-1. Epub 2016 Jun 4. PMID: 27262299.
https://pubmed.ncbi.nlm.nih.gov/27262299/
80. Rubel R, Santa HSD, Dos Santos LF, Fernandes LC, Figueiredo BC, Soccol CR. Immunomodulatory and Antitumoral Properties of Ganoderma lucidum and Agaricus brasiliensis (Agaricomycetes) Medicinal Mushrooms. Int J Med Mushrooms. 2018;20(4):393-403. doi: 10.1615/IntJMedMushrooms.2018025979. PMID: 29953399.
https://pubmed.ncbi.nlm.nih.gov/29953399/
81. Kerezoudi EN, Mitsou EK, Gioti K, Terzi E, Avgousti I, Panagiotou A, Koutrotsios G, Zervakis GI, Mountzouris KC, Tenta R, Kyriacou A. Fermentation of Pleurotus ostreatus and Ganoderma lucidum mushrooms and their extracts by the gut microbiota of healthy and osteopenic women: potential prebiotic effect and impact of mushroom fermentation products on human osteoblasts. Food Funct. 2021 Mar 1;12(4):1529-1546. doi: 10.1039/d0fo02581j. PMID: 33521800.
https://pubmed.ncbi.nlm.nih.gov/33521800/
82. Mitsou EK, Saxami G, Stamoulou E, Kerezoudi E, Terzi E, Koutrotsios G, Bekiaris G, Zervakis GI, Mountzouris KC, Pletsa V, Kyriacou A. Effects of Rich in Β-Glucans Edible Mushrooms on Aging Gut Microbiota Characteristics: An In Vitro Study. Molecules. 2020 Jun 18;25(12):2806. doi: 10.3390/molecules25122806. PMID: 32570735; PMCID: PMC7355846.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7355846/
83. Health benefits of turkey tail mushrooms, Medically reviewed by Jerlyn Jones, MS MPA RDN LD CLT, Nutrition — Written by Jennifer Berry — Updated on August 6, 2024
https://www.medicalnewstoday.com/articles/turkey-tail-mushroom
84. Rathee, Sushila et al. “Mushrooms as therapeutic agents.” Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy 22 (2012): 459-474.
https://www.semanticscholar.org/paper/Mushrooms-as-therapeutic-agents-Rathee-Rathee/1b648a5608279ef1c8c45c8b334b64a3d67f5131
85. Zięba P, Sękara A, Sułkowska-Ziaja K, Muszyńska B. Culinary and Medicinal Mushrooms: Insight into Growing Technologies. Acta Mycologica. 2020;55(2):1. doi:10.5586/am.5526.
https://www.journalssystem.com/amy/Culinary-and-Medicinal-Mushrooms-Insight-into-Growing-Technologies,159745,0,2.html#ungrouped
86. Carsten Gründemann, Jakob K. Reinhardt, Ulrike Lindequist, European medicinal mushrooms: Do they have potential for modern medicine? – An update, Phytomedicine, Volume 66, 2020, 153131, ISSN 0944-7113, https://doi.org/10.1016/j.phymed.2019.153131.
https://www.sciencedirect.com/science/article/abs/pii/S0944711319303848
87. International Journal of Medicinal Mushrooms Editor-in-Chief: Solomon P. Wasser, BEGELL HOUSE Inc
https://www.begellhouse.com/journals/medicinal-mushrooms.html
88. Jeitler M, Michalsen A, Frings D, Hübner M, Fischer M, Koppold-Liebscher DA, Murthy V and Kessler CS (2020) Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review. Front. Pharmacol. 11:580656. doi: 10.3389/fphar.2020.580656
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.580656/full
89. Rahi, Deepak K., Malik, Deepika, Diversity of Mushrooms and Their Metabolites of Nutraceutical and Therapeutic Significance, Journal of Mycology, 2016, 7654123, 18 pages, 2016. https://doi.org/10.1155/2016/7654123
https://onlinelibrary.wiley.com/doi/10.1155/2016/7654123
90. Slomski A. Trials Test Mushrooms and Herbs as Anti–COVID-19 Agents. JAMA. 2021;326(20):1997–1999. doi:10.1001/jama.2021.19388
https://jamanetwork.com/journals/jama/fullarticle/2786023
91. Exploring the Uses of the Top Medicinal Mushrooms, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Tarikh Input: 22/02/2023 | Kemaskini: 04/04/2023 | aslamiah
https://sgs.upm.edu.my/artikel/exploring_the_uses_of_the_top_medicinal_mushrooms-71534
92. Fokunang, Estella & Annih, Mbong & Abongwa, Lem & Bih, Manju & Vanessa Edwige, Tchadji & Fonmboh, Dobgima & Fokunang, Charles. (2022). Medicinal Mushroom of Potential Pharmaceutical Toxic Importance: Contribution in Phytotherapy. 10.5772/intechopen.103845.
https://www.intechopen.com/chapters/81313
93. Mohammad A Rahman, T Rahman, M Rahman, M Arif. (2022). Usage of Mushrooms in Culinary and Medicinal Purposes. Biomedical Research and Clinical Reviews. 6(1); DOI: 10.31579/2692-9406/087
https://www.auctoresonline.org/article/usage-of-mushrooms-in-culinary-and-medicinal-purposes
94. Shahar O, Pereman I, Khamisie H, Ezov N, Danay O, Khattib A, Schweitzer R, Khatib S, Mahajna J. Compounds originating from the edible mushroom Auricularia auricula-judae inhibit tropomyosin receptor kinase B activity. Heliyon. 2023 Feb 16;9(3):e13756. doi: 10.1016/j.heliyon.2023.e13756. PMID: 36895384; PMCID: PMC9988514.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9988514/
95. Global Functional Mushroom Market Size Likely to Grow at a CAGR of 11.5% By 2033 Released Date: May 4, 2024 | Author Name: Katelin Kharrati | Location: Sandy, USA
https://www.custommarketinsights.com/press-releases/functional-mushroom-market-size/
96. Medicinal Mushroom Market Size, Share, Growth, and Industry Analysis, By Type (Reishi Mushroom, Chaga Mushroom, Lion’s Mane Mushrooms, Cordyceps, & Others), By Application (Household, Commercial), Regional Insights, and Forecast To 2032 Last Updated: 30 December 2024 Base Year: 2024 Historical Data: 2020-2023 No of Pages: 105
https://www.businessresearchinsights.com/market-reports/medicinal-mushroom-market-113833
97. Cordyceps Is a Killer Fungi With Potential Health Benefits, March 10, 2023, Cleveland Clinic
https://health.clevelandclinic.org/cordyceps-benefits
98. Blagodatski A., Yatsunskaya M., Mikhailova V., Tiasto V., Kagansky A., Katanaev V. L. Medicinal mushrooms as an attractive new source of natural compounds for future cancer therapy. Oncotarget. 2018; 9: 29259-29274.
https://www.oncotarget.com/article/25660/text/
99. HURIEZ C. Indications actuelles de la mycothérapie [Current indications of mycotherapy]. Paris Med. 1945 Nov 30;35:374-80. French. PMID: 21021559.
https://pubmed.ncbi.nlm.nih.gov/21021559/
100. DIOT. Premiers essais de mycothérapie dans les affections pyogènes et leurs résultats [First trials of mycotherapy in pyogenic conditions and their results]. Maroc Med. 1946 Feb-Mar;25(258):10-2. French. PMID: 20993868.
https://pubmed.ncbi.nlm.nih.gov/20993868/
101. CHABROL E. La mycothérapie dans les cirrhoses du foie [Mycotherapy in liver cirrhosis]. Presse Therm Clim. 1949 Jan-Feb;86(1-2):1-5. French. PMID: 18115812.
https://pubmed.ncbi.nlm.nih.gov/18115812/
102. KOURILSKY R. La mycothérapie dans la tuberculose pulmonaire chronique [Mycotherapy in chronic pulmonary tuberculosis]. Laval Med. 1949 Dec;14(10):1319-40. French. PMID: 15408327.
https://pubmed.ncbi.nlm.nih.gov/15408327/
103. Guggenheim AG, Wright KM, Zwickey HL. Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology. Integr Med (Encinitas). 2014 Feb;13(1):32-44. PMID: 26770080; PMCID: PMC4684115.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4684115/
104. Mau JL, Lin HC, Chen CC. Antioxidant properties of several medicinal mushrooms. J Agric Food Chem. 2002 Oct 9;50(21):6072-7. doi: 10.1021/jf0201273. PMID: 12358482.
https://pubmed.ncbi.nlm.nih.gov/12358482/
105. Geng, Ping, Siu, Ka-Chai, Wang, Zhaomei, Wu, Jian-Yong, Antifatigue Functions and Mechanisms of Edible and Medicinal Mushrooms, BioMed Research International, 2017, 9648496, 16 pages, 2017. https://doi.org/10.1155/2017/9648496
https://onlinelibrary.wiley.com/doi/10.1155/2017/9648496
106. Podkowa, A., Kryczyk-Poprawa, A., Opoka, W. et al. Culinary–medicinal mushrooms: a review of organic compounds and bioelements with antioxidant activity. Eur Food Res Technol 247, 513–533 (2021). https://doi.org/10.1007/s00217-020-03646-1
https://link.springer.com/article/10.1007/s00217-020-03646-1
107. Merdivan, S., Lindequist, U. (2017). Medicinal Mushrooms with Antiallergic Activities. In: Agrawal, D., Tsay, HS., Shyur, LF., Wu, YC., Wang, SY. (eds) Medicinal Plants and Fungi: Recent Advances in Research and Development. Medicinal and Aromatic Plants of the World, vol 4. Springer, Singapore. https://doi.org/10.1007/978-981-10-5978-0_4
https://link.springer.com/chapter/10.1007/978-981-10-5978-0_4
108. Alvandi, H., Ansari, E. ., Kianirad, S. ., Hatamian-Zarmi, A., Mokhtari Hosseini, Z. B., & Ebrahimi-Hosseinzadeh, B. (2022). Medicinal mushrooms as potential therapeutic agents in the treatment of diabetes mellitus: a review with focusing on in vivo and clinical studies. Italian Journal of Mycology, 51(1), 75–96. https://doi.org/10.6092/issn.2531-7342/15023
https://italianmycology.unibo.it/article/view/15023
109. De Silva, D.D., Rapior, S., Hyde, K.D. et al. Medicinal mushrooms in prevention and control of diabetes mellitus. Fungal Diversity 56, 1–29 (2012). https://doi.org/10.1007/s13225-012-0187-4
https://link.springer.com/article/10.1007/s13225-012-0187-4
110. Ebru Deveci, Fatih Çayan, Gülsen Tel-Çayan, Mehmet Emin Duru, Inhibitory activities of medicinal mushrooms on α-amylase and α-glucosidase-enzymes related to type 2 diabetes, South African Journal of Botany, Volume 137, 2021, Pages 19-23, ISSN 0254-6299, https://doi.org/10.1016/j.sajb.2020.09.039.
https://www.sciencedirect.com/science/article/pii/S025462992031111X
111. Al Qutaibi, Mohammed, Kagne, Suresh R., Unearthing Nature’s Pharmacy: Exploring the Antimicrobial Potency of Mushrooms, Journal of Food Processing and Preservation, 2024, 8331974, 14 pages, 2024. https://doi.org/10.1155/2024/8331974
https://onlinelibrary.wiley.com/doi/full/10.1155/2024/8331974
112. Ashaimaa Y. Moussa, Shaimaa Fayez, Hang Xiao, Baojun Xu, New insights into antimicrobial and antibiofilm effects of edible mushrooms, Food Research International, Volume 162, Part A, 2022, 111982, ISSN 0963-9969, https://doi.org/10.1016/j.foodres.2022.111982.
https://www.sciencedirect.com/science/article/abs/pii/S0963996922010407
113. The Antimicrobial Benefits of Mushrooms, U.S. department of agriculture,
https://tellus.ars.usda.gov/stories/articles/antimicrobial-benefits-mushrooms
114. Soares AA, de Sá-Nakanishi AB, Bracht A, da Costa SM, Koehnlein EA, de Souza CG, Peralta RM. Hepatoprotective effects of mushrooms. Molecules. 2013 Jul 1;18(7):7609-30. doi: 10.3390/molecules18077609. PMID: 23884116; PMCID: PMC6270077.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6270077/
115. Yadav SK, Ir R, Jeewon R, Doble M, Hyde KD, Kaliappan I, Jeyaraman R, Reddi RN, Krishnan J, Li M, Durairajan SSK. A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders. Planta Med. 2020 Nov;86(16):1161-1175. doi: 10.1055/a-1177-4834. Epub 2020 Jul 14. PMID: 32663897.
https://www.thieme-connect.com/products/ejournals/pdf/10.1055/a-1177-4834.pdf
116. McCain, P. et al. (2023). Cognitive Enhancing Effects of Medicinal Mushrooms: A Potential Neuroprotective Implication in Dementias. In: Agrawal, D.C., Dhanasekaran, M. (eds) Mushrooms with Therapeutic Potentials. Springer, Singapore. https://doi.org/10.1007/978-981-19-9550-7_8
https://link.springer.com/chapter/10.1007/978-981-19-9550-7_8#citeas
117. Vikineswary Sabaratnam, Chia-Wei Phan, Chapter 10 - Neuroactive Components of Culinary and Medicinal Mushrooms With Potential to Mitigate Age-Related Neurodegenerative Diseases, Editor(s): Goutam Brahmachari, In Natural Product Drug Discovery, Discovery and Development of Neuroprotective Agents from Natural Products, Elsevier, 2018, Pages 401-413, ISBN 9780128095935, https://doi.org/10.1016/B978-0-12-809593-5.00010-0.
https://www.sciencedirect.com/science/article/abs/pii/B9780128095935000100
118. Mushrooms with Therapeutic Potentials Recent Advances in Research and Development, Book, 2023, Springer Nature
https://link.springer.com/book/10.1007/978-981-19-9550-7
119. Medicinal Mushrooms Help Fight Cognitive Decline & Protect Your Brain, Food for the Brain, Sophie Barret – Hifas da Terra & Patrick Holford
https://foodforthebrain.org/medicinal-mushrooms-help-fight-cognitive-decline-protect-your-brain/
120. Badalyan, Susanna & Rapior, Sylvie. (2020). AGARICOMYCETES MEDICINAL MUSHROOMS WITH POTENTIAL NEUROPROTECTIVE ACTIVITY GROWING IN ARMENIA. 54. 196-203. 10.46991/PYSU:B/2020.54.3.196.
https://hal.umontpellier.fr/hal-03090953v1/document
121. Srivastava, Anuradha & Attri, BL & Sharma, VP. (2020). Status report on mushroom based nutraceutical products in the market. Mushroom Research. 28. 10.36036/MR.28.2.2020.97575.
https://www.researchgate.net/publication/341518522_Status_report_on_mushroom_based_nutraceutical_products_in_the_market
122. Niego AG, Rapior S, Thongklang N, Raspé O, Jaidee W, Lumyong S, Hyde KD. Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value. J Fungi (Basel). 2021 May 19;7(5):397. doi: 10.3390/jof7050397. PMID: 34069721; PMCID: PMC8161071.
https://pubmed.ncbi.nlm.nih.gov/34069721
123. Book, Mushrooms Nutraceuticals and Functional Foods, Deepu Pandita, Anu Pandita, Taylor & Francis
https://www.taylorfrancis.com/books/edit/10.1201/9781003322238/mushrooms-deepu-pandita-anu-pandita
124. Khatun, Selima et al. “Research on Mushroom as a Potential Source of Nutraceuticals: A Review on Indian Perspective.” American Journal of Experimental Agriculture 2 (2012): 47-73.
https://britishagroproducts.com/pdf/Mushroom%20as%20a%20Potential%20source%20of%20Nutraceuticals.pdf
125. Mankar, Someshwar & Thombare, Shailesh & Todmal, Tejas & Waghe, Raj & Borde, Akash. (2022). Medicinal Mushroom: An Ancient culture towards new lifestyle. Research Journal of Pharmacognosy and Phytochemistry. 50-54. 10.52711/0975-4385.2022.00011.
https://rjpponline.org/HTML_Papers/Research%20Journal%20of%20Pharmacognosy%20and%20Phytochemistry__PID__2022-14-1-11.html
126. Gargano, M. L., van Griensven, L. J. L. D., Isikhuemhen, O. S., Lindequist, U., Venturella, G., Wasser, S. P., & Zervakis, G. I. (2017). Medicinal mushrooms: Valuable biological resources of high exploitation potential. Plant Biosystems - An International Journal Dealing with All Aspects of Plant Biology, 151(3), 548–565. https://doi.org/10.1080/11263504.2017.1301590
https://www.tandfonline.com/doi/abs/10.1080/11263504.2017.1301590
127. Chapter Medicinal mushroom nutraceutical commercialization: Two sides of a coin, Jovana VundukORCID Icon, Daniel Tura, Alona Yu. BiketovaORCID Icon, Book Wild Mushrooms, Taylor & Francis
https://www.taylorfrancis.com/chapters/edit/10.1201/9781003152583-5/medicinal-mushroom-nutraceutical-commercialization-two-sides-coin-jovana-vunduk-daniel-tura-alona-yu-biketova
128. CHABROL E. La mycotherapie dans les affections du foie et des voies biliaires [Mycotherapy in affections of the liver and bile ducts]. Rev Prat. 1952 Apr 1;2(10):613-4. Undetermined Language. PMID: 13028009.
https://pubmed.ncbi.nlm.nih.gov/13028009/
129. integrative medicine, National Cancer Institute
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/integrative-medicine
130. The University of Arizona, Episode #18 A Kingdom of Their Own - How Fungi Shape Our World with Merlin Sheldrake
https://awcim.arizona.edu/podcast/episode18_sheldrake.html
131. The Magic of Medicinal Mushrooms, The National Centre for Integrative Medicine, Dr Elizabeth Thompson
https://ncim.org.uk/the-magic-of-medicinal-mushrooms
132. Mycotherapy for women’s health 07 Jun 2024, PhD. Catalina Fernandez de Ana Portela, Integrative & Personalised Medicine
https://ipmcongress.com/2024-workshop-programme/mycotherapy-womens-health-discover-medicinal-mushrooms-support-different-phases-womanhood-hormonal-metabolic-challenges-emotional-balance-vaginal-health
133. Mycotherapy, Onkoklinika, Russia
https://onco.rehab/en/fields/mycotherapy/
134. Clinical Experience About the Use of Complementary and Alternative Medicine in Spain, Dr. Maria Assuncion Peiré Catalano Institute of Health, Barcelona, Spain
https://www.europeanreview.org/wp/wp-content/uploads/9457-9466.pdf
135. Children's Hospital at Montefiore, Bronx, NY.
https://www.cham.org/HealthwiseArticle.aspx?id=ncicdr0000778943
136. Memorial Sloan Kettering Cancer Center, Thursday, February 9, 2023, Reishi Mushroom
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/reishi-mushroom
137. Mushrooms and Cancer Nov 11, British Society for Integrative Oncology
https://www.bsio.org.uk/blog/mushrooms-and-cancer
138. Mycomedicinals (Mushrooms) for Cancer, Srivani Sridhar, MD (2014, updated 2020).
https://www.va.gov/WHOLEHEALTHLIBRARY/tools/mycomedicinals-mushrooms-for-cancer.asp
139. 2008 A Guide to Integrative Oncology University of Washington | Bastyr University
https://depts.washington.edu/psworks/integrative/clinicians/act/mushroom_extracts.shtml
140. Chugh RM, Mittal P, Mp N, Arora T, Bhattacharya T, Chopra H, Cavalu S, Gautam RK. Fungal Mushrooms: A Natural Compound With Therapeutic Applications. Front Pharmacol. 2022 Jul 13;13:925387. doi: 10.3389/fphar.2022.925387. PMID: 35910346; PMCID: PMC9328747.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9328747/
141. Adaptogenic or Medicinal Mushrooms, Published April 20, 2009, M. Saljoughian, PharmD, PhD Alta Bates Summit Medical Center Department of Pharmacy Services Berkeley, California,
https://www.uspharmacist.com/article/adaptogenic-or-medicinal-mushrooms
142. Adaptogens, Cleveland Clinic, Last reviewed on 02/10/2022.
https://my.clevelandclinic.org/health/drugs/22361-adaptogens
143. What are adaptogens and should you be taking them? February 16, 2022 By uclahealth,
https://www.uclahealth.org/news/article/what-are-adaptogens-and-should-you-be-taking-them
144. Medicinal Mushrooms and their history of therapeutic uses, Sophie Barrett, Medical Herbalist, Naturopath, Faculty of Homeopathy
https://www.facultyofhomeopathy.org/events/medicinal-mushrooms-their-history-of-therapeutic-uses
145. Bocharova OA. Adaptogeny kak sredstva profilakticheskoĭ onkologii [Adaptogens as agents for prophylactic oncology]. Vestn Ross Akad Med Nauk. 1999;(5):49-53. Russian. PMID: 10394302.
https://pubmed.ncbi.nlm.nih.gov/10394302/
146. Panossian A, Wikman G, Kaur P, Asea A. Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones. Phytomedicine. 2009 Jun;16(6-7):617-22. doi: 10.1016/j.phymed.2008.12.003. Epub 2009 Feb 1. PMID: 19188053.
https://pubmed.ncbi.nlm.nih.gov/19188053
147. Khanum F, Bawa AS, Singh B. Rhodiola rosea: A Versatile Adaptogen. Compr Rev Food Sci Food Saf. 2005 Jul;4(3):55-62. doi: 10.1111/j.1541-4337.2005.tb00073.x. PMID: 33430554.
https://pubmed.ncbi.nlm.nih.gov/33430554/
148. Blyumin-Karasik M, Colon J, Nguyen S, Rosen J. Laser and Skin-Care Synergy: A Post-Laser Application of Novel Adaptogenic Moisturizing Serum for Improving Healing and Cosmesis on the Face. J Cosmet Dermatol. 2024 Nov 6. doi: 10.1111/jocd.16668. Epub ahead of print. PMID: 39503217.
https://pubmed.ncbi.nlm.nih.gov/39503217/
149. Liu XX, Chen CY, Li L, Guo MM, He YF, Meng H, Dong YM, Xiao PG, Yi F. Bibliometric Study of Adaptogens in Dermatology: Pharmacophylogeny, Phytochemistry, and Pharmacological Mechanisms. Drug Des Devel Ther. 2023 Feb 6;17:341-361. doi: 10.2147/DDDT.S395256. PMID: 36776447; PMCID: PMC9912821.
https://pubmed.ncbi.nlm.nih.gov/36776447/
150. KrishnaRaju AV, Somepalli V, Thanawala S, Shah R. Efficacy and Anti-Inflammatory Activity of Ashwagandha Sustained-Release Formulation on Depression and Anxiety Induced by Chronic Unpredictable Stress: in vivo and in vitro Studies. J Exp Pharmacol. 2023 Jul 25;15:291-305. doi: 10.2147/JEP.S407906. PMID: 37521489; PMCID: PMC10386834.
https://pubmed.ncbi.nlm.nih.gov/37521489/
151. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012 Jul;34(3):255-62. doi: 10.4103/0253-7176.106022. PMID: 23439798; PMCID: PMC3573577.
https://pubmed.ncbi.nlm.nih.gov/23439798/
152. Okoh L, Ajayi AM, Ben-Azu B, Akinluyi ET, Emokpae O, Umukoro S. D-Ribose-L-cysteine exhibits adaptogenic-like activity through inhibition of oxido-inflammatory responses and increased neuronal caspase-3 activity in mice exposed to unpredictable chronic mild stress. Mol Biol Rep. 2020 Oct;47(10):7709-7722. doi: 10.1007/s11033-020-05845-1. Epub 2020 Sep 21. PMID: 32959196.
https://pubmed.ncbi.nlm.nih.gov/32959196/
153. Wróbel-Biedrawa D, Podolak I. Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review. Molecules. 2024 Feb 15;29(4):866. doi: 10.3390/molecules29040866. PMID: 38398618; PMCID: PMC10891670.
https://pubmed.ncbi.nlm.nih.gov/38398618/
154. Panossian A. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals. Ann N Y Acad Sci. 2017 Aug;1401(1):49-64. doi: 10.1111/nyas.13399. Epub 2017 Jun 22. PMID: 28640972.
https://pubmed.ncbi.nlm.nih.gov/28640972
155. Chakraborty, Nilanjana et al. “Mushroom Polysaccharides: a Potent Immune-Modulator.” Biointerface Research in Applied Chemistry (2020): n. pag.
https://biointerfaceresearch.com/wp-content/uploads/2020/08/20695837112.89158930.pdf
156. Bhushan, Apoorva; Kulshreshtha, Mayank. The Medicinal Mushroom Agaricus bisporus: Review of Phytopharmacology and Potential Role in the Treatment of Various Diseases. Journal of Nature and Science of Medicine 1(1):p 4-9, Jan–Jun 2018. | DOI: 10.4103/JNSM.JNSM_1_18
https://journals.lww.com/jnsm/fulltext/2018/01010/the_medicinal_mushroom_agaricus_bisporus__review.3.aspx
157. Elkhateeb, Waill & Daba, Ghoson & Elnahas, Marwa & Thomas, Paul. (2019). Anticoagulant Capacities of Some Medicinal Mushrooms. Journal of Pharmaceutical Sciences. 5. 12-16.
https://www.researchgate.net/publication/336231517_Anticoagulant_Capacities_of_Some_Medicinal_Mushrooms
158. Rahul Mehta. 2020. Anti-thrombotic Attribute of Different Type of Mushrooms.Int.J.Curr.Microbiol.App.Sci. 9(8): 815-820. doi: https://doi.org/10.20546/ijcmas.2020.908.087
https://www.ijcmas.com/abstractview.php?ID=18640&vol=9-8-2020&SNo=87
159. Sabaratnam, Vikineswary & Ali, Shahjahan & Tieng, Kho & Tieng, – & Chiew-Pin, Teo & Panjavaranam, Kayathri & Tan, Yee Shin & Ling, Tau & Kek-Heng, Chua & Muniandy, Sekaran. (2013). FIBRINOLYTIC AND ANTICOAGULANT ENZYMES OF SELECTED MEDICINAL AND CULINARY MUSHROOMS.
https://www.researchgate.net/publication/264977421_FIBRINOLYTIC_AND_ANTICOAGULANT_ENZYMES_OF_SELECTED_MEDICINAL_AND_CULINARY_MUSHROOMS
160. Seon-Joo Yoon, Myeong-Ae Yu, Yu-Ryang Pyun, Jae-Kwan Hwang, Djong-Chi Chu, Lekh Raj Juneja, Paulo A.S. Mourão, The nontoxic mushroom Auricularia auricula contains a polysaccharide with anticoagulant activity mediated by antithrombin, Thrombosis Research, Volume 112, Issue 3, 2003, Pages 151-158, ISSN 0049-3848, https://doi.org/10.1016/j.thromres.2003.10.022.
https://www.sciencedirect.com/science/article/abs/pii/S0049384803005504
161. Nataraj, A.; Govindan, S.; Ramani, P.; Subbaiah, K.A.; Sathianarayanan, S.; Venkidasamy, B.; Thiruvengadam, M.; Rebezov, M.; Shariati, M.A.; Lorenzo, J.M.; et al. Antioxidant, Anti-Tumour, and Anticoagulant Activities of Polysaccharide from Calocybe indica (APK2). Antioxidants 2022, 11, 1694. https://doi.org/10.3390/antiox11091694
https://www.mdpi.com/2076-3921/11/9/1694
162. Safety of Medicinal Mushrooms in Patients With Cancer November 14, 2017, Oncology Nursing Society
https://www.ons.org/publications-research/voice/news-views/11-2017/safety-medicinal-mushrooms-patients-cancer
163. MedlinePlus, Reishi Mushroom, 08/16/2022,
https://medlineplus.gov/druginfo/natural/905.html
164. Jakopovich I. New dietary supplements from medicinal mushrooms: Dr Myko San--a registration report. Int J Med Mushrooms. 2011;13(3):307-13. doi: 10.1615/intjmedmushr.v13.i3.110. PMID: 22135883.
https://pubmed.ncbi.nlm.nih.gov/22135883/
165. Roda, Elisa, et al. "From a medicinal mushroom blend a direct anticancer effect on triple-negative breast cancer: a preclinical study on lung metastases." Molecules 25.22 (2020): 5400.
Google Scholar
166. De Luca, Fabrizio, et al. "Fighting secondary triple-negative breast cancer in cerebellum: a powerful aid from a medicinal mushrooms blend." Biomedicine & Pharmacotherapy 159 (2023): 114262.
Google Scholar
167. Abdullah, E.; Abidin, N.Z.; Abdullah, N. Cytotoxic Proteins from King Tuber Oyster Medicinal Mushroom, Pleurotus Tuber-Regium (Agaricomycetes), Sclerotium against Human MDA-MB-231 Breast Cancer Cells. Int. J. Med. Mushrooms 2022, 24, 27–40
Google Scholar
168. Wong JH, Ng TB, Chan HHL, Liu Q, Man GCW, Zhang CZ, Guan S, Ng CCW, Fang EF, Wang H, Liu F, Ye X, Rolka K, Naude R, Zhao S, Sha O, Li C, Xia L. Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials. Appl Microbiol Biotechnol. 2020 Jun;104(11):4675-4703. doi: 10.1007/s00253-020-10476-4. Epub 2020 Apr 9. PMID: 32274562.
https://pubmed.ncbi.nlm.nih.gov/32274562/
169. Cai H, Li J, Gu B, Xiao Y, Chen R, Liu X, Xie X, Cao L. Extracts of Cordyceps sinensis inhibit breast cancer cell metastasis via down-regulation of metastasis-related cytokines expression. J Ethnopharmacol. 2018 Mar 25;214:106-112. doi: 10.1016/j.jep.2017.12.012. Epub 2017 Dec 15. PMID: 29253616.
https://pubmed.ncbi.nlm.nih.gov/29253616/
170. Zhong C, Li Y, Li W, Lian S, Li Y, Wu C, Zhang K, Zhou G, Wang W, Xu H, Huang M, Katanaev V, Jia L, Lu Y. Ganoderma lucidum extract promotes tumor cell pyroptosis and inhibits metastasis in breast cancer. Food Chem Toxicol. 2023 Apr;174:113654. doi: 10.1016/j.fct.2023.113654. Epub 2023 Feb 8. PMID: 36758785.
https://pubmed.ncbi.nlm.nih.gov/36758785/
171. Martínez-Montemayor, Michelle M., et al. "Ganoderma lucidum (Reishi) inhibits cancer cell growth and expression of key molecules in inflammatory breast cancer." Nutrition and cancer 63.7 (2011): 1085-1094.
Google Scholar
172. Zhang Y, Sun D, Meng Q, Guo W, Chen Q, Zhang Y. [Corrigendum] Grifola frondosa polysaccharides induce breast cancer cell apoptosis via the mitochondrial-dependent apoptotic pathway. Int J Mol Med. 2022 Nov;50(5):136. doi: 10.3892/ijmm.2022.5192. Epub 2022 Sep 21. Erratum for: Int J Mol Med. 2017 Oct;40(4):1089-1095. doi: 10.3892/ijmm.2017.3081. PMID: 36129150; PMCID: PMC9559173.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9559173/
173. Hseu, You-Cheng, et al. "Antrodia salmonea suppresses invasion and metastasis in triple-negative breast cancer cells by reversing EMT through the NF-κB and Wnt/β-catenin signaling pathway." Food and Chemical Toxicology 124 (2019): 219-230.
https://pubmed.ncbi.nlm.nih.gov/30529123/
174. Karnofsky Performance Status Scale, Jan 19, 2023, WebMD, Buck Christensen; Buck Christensen
https://emedicine.medscape.com/article/2172510-overview?form=fpf
175. Survey Finds Brain Health is a Top Priority for Americans a woman smiling at the camera By Paula Croxson, Ph.D. Dana Foundation
https://dana.org/article/survey-finds-brain-health-is-a-top-priority-for-americans/
176. Avan A, Hachinski V, the Brain Health Learn, Act Group. Brain health: Key to health, productivity, and well-being. Alzheimer's Dement. 2022; 18: 1396–1407. https://doi.org/10.1002/alz.12478
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12478
177. World Health Organisation’s Global Health Estimates reveal dementia as a top three cause of death in Europe, Alzheimer Europe, 09/12/2020
https://www.alzheimer-europe.org/news/world-health-organisations-global-health-estimates-reveal-dementia-top-three-cause-death?language_content_entity=en
178. ReFaey K, Tripathi S, Grewal SS, Bhargav AG, Quinones DJ, Chaichana KL, Antwi SO, Cooper LT, Meyer FB, Dronca RS, Diasio RB, Quinones-Hinojosa A. Cancer Mortality Rates Increasing vs Cardiovascular Disease Mortality Decreasing in the World: Future Implications. Mayo Clin Proc Innov Qual Outcomes. 2021 Jun 8;5(3):645-653. doi: 10.1016/j.mayocpiqo.2021.05.005. PMID: 34195556; PMCID: PMC8240359.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8240359/
179. Alzheimer's Disease Facts and Figures, Alzheimer's Association
https://www.alz.org/alzheimers-dementia/facts-figures
180. Lewis JE, Poles J, Shaw DP, et al. The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. Journal of Clinical and Translational Research. 2021 Aug;7(4):575-620. PMID: 34541370; PMCID: PMC8445631.
https://europepmc.org/article/MED/34541370
181. Yiannopoulou KG, Papageorgiou SG. Current and Future Treatments in Alzheimer Disease: An Update. J Cent Nerv Syst Dis. 2020 Feb 29;12:1179573520907397. doi: 10.1177/1179573520907397. PMID: 32165850; PMCID: PMC7050025.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7050025/
182. 22 August, 2024, RightCare dementia scenario, NHS England
https://www.england.nhs.uk/long-read/rightcare-dementia-scenario/
183. Neuroscience, Brain Health and Nutrients, Clinical Education
https://www.clinicaleducation.org/brain-health/neuroscience-brain-health-and-nutrients/
184. Stamets P, Zwickey H. Medicinal Mushrooms: Ancient Remedies Meet Modern Science. Integr Med (Encinitas). 2014 Feb;13(1):46-7. PMID: 26770081; PMCID: PMC4684114.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4684114/
185. Zhang S, Zhang S, Tomata Y, et al. Mushroom Consumption and Incident Dementia in Elderly Japanese: The Ohsaki Cohort 2006 Study. Journal of the American Geriatrics Society. 2017 Jul;65(7):1462-1469. DOI: 10.1111/jgs.14812. PMID: 28295137.
https://europepmc.org/article/MED/28295137
186. Yin Z, Chen J, Zhang J, et al. Dietary Patterns Associated with Cognitive Function among the Older People in Underdeveloped Regions: Finding from the NCDFaC Study. Nutrients. 2018 Apr;10(4):E464. DOI: 10.3390/nu10040464. PMID: 29642510; PMCID: PMC5946249.
https://europepmc.org/article/MED/29642510
187. Shang X, Hodge AM, Hill E, Zhu Z, He M. Associations of Dietary Pattern and Sleep Duration with Cognitive Decline in Community-Dwelling Older Adults: A Seven-Year Follow-Up Cohort Study. J Alzheimers Dis. 2021;82(4):1559-1571. doi: 10.3233/JAD-201329. PMID: 34180411.
https://pubmed.ncbi.nlm.nih.gov/34180411/
188. Sabaratnam V, Kah-Hui W, Naidu M, Rosie David P. Neuronal health - can culinary and medicinal mushrooms help? J Tradit Complement Med. 2013 Jan;3(1):62-8. doi: 10.4103/2225-4110.106549. PMID: 24716157; PMCID: PMC3924982.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3924982/
189. Stephen McMahon, Beth Murinson, CHAPTER 25 - Therapeutic Potential of Neurotrophic Factors, Editor(s): Stephen Waxman, From Neuroscience To Neurology, Academic Press, 2005, Pages 419-431, ISBN 9780127389035, https://doi.org/10.1016/B978-012738903-5/50026-6.
https://www.sciencedirect.com/science/article/abs/pii/B9780127389035500266
190. Ganesan, Anusiya & Udayakumar, Gowthama Prabu & Yamini, N & Sivarajasekar, N. & K, Rambabu & Govindan, Bharath & Banat, Fawzi. (2021). A review of the therapeutic and biological effects of edible and wild mushrooms. Bioengineered. 12. 10.1080/21655979.2021.2001183.
https://www.researchgate.net/publication/355953195_A_review_of_the_therapeutic_and_biological_effects_of_edible_and_wild_mushrooms
191. Mushrooms magnify memory by boosting nerve growth, 10 February 2023, The University of Queensland
https://www.uq.edu.au/news/article/2023/02/mushrooms-magnify-memory-boosting-nerve-growth-0
192. Eik LF, Naidu M, David P, Wong KH, Tan YS, Sabaratnam V. Lignosus rhinocerus (Cooke) Ryvarden: A Medicinal Mushroom That Stimulates Neurite Outgrowth in PC-12 Cells. Evid Based Complement Alternat Med. 2012;2012:320308. doi: 10.1155/2012/320308. Epub 2011 Dec 6. PMID: 22203867; PMCID: PMC3235797.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3235797/
193. Khodosevich, K., Monyer, H. Signaling involved in neurite outgrowth of postnatally born subventricular zone neurons in vitro. BMC Neurosci 11, 18 (2010). https://doi.org/10.1186/1471-2202-11-18
https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-11-18
194. Miller KE and Suter DM (2018) An Integrated Cytoskeletal Model of Neurite Outgrowth. Front. Cell. Neurosci. 12:447. doi: 10.3389/fncel.2018.00447
https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2018.00447/full
195. Szućko-Kociuba I, Trzeciak-Ryczek A, Kupnicka P, Chlubek D. Neurotrophic and Neuroprotective Effects of Hericium erinaceus. Int J Mol Sci. 2023 Nov 3;24(21):15960. doi: 10.3390/ijms242115960. PMID: 37958943; PMCID: PMC10650066.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10650066/
196. Aloe L, Rocco ML, Balzamino BO, Micera A. Nerve Growth Factor: A Focus on Neuroscience and Therapy. Curr Neuropharmacol. 2015;13(3):294-303. doi: 10.2174/1570159x13666150403231920. PMID: 26411962; PMCID: PMC4812798.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4812798/
197. Capossela, L.; Gatto, A.; Ferretti, S.; Di Sarno, L.; Graglia, B.; Massese, M.; Soligo, M.; Chiaretti, A. Multifaceted Roles of Nerve Growth Factor: A Comprehensive Review with a Special Insight into Pediatric Perspectives. Biology 2024, 13, 546. https://doi.org/10.3390/biology13070546
https://www.mdpi.com/2079-7737/13/7/546
198. Zhang, Y., Chen, H., Li, R. et al. Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future. Sig Transduct Target Ther 8, 248 (2023). https://doi.org/10.1038/s41392-023-01484-7
https://www.nature.com/articles/s41392-023-01484-7
199. Murphy MP, LeVine H 3rd. Alzheimer's disease and the amyloid-beta peptide. J Alzheimers Dis. 2010;19(1):311-23. doi: 10.3233/JAD-2010-1221. PMID: 20061647; PMCID: PMC2813509.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2813509/
200. Ancient medicine could hold the key to dementia treatment, The University of Queensland
https://stories.uq.edu.au/research/2023/ancient-medicine-could-hold-key-to-dementia-treatment/index.html
201. Fear of dementia overtakes cancer for older Australians, as new study looks at lifestyle and diet options By medical reporter Sophie Scott and the Specialist Reporting Team's Brooke Wylie, Mon 25 Nov 2019, ABC News
https://www.abc.net.au/news/2019-11-26/dementia-lifestyle-exercise-diet-options-give-hint-at-prevention/11722796
202. Dementia tsunami: Alzheimer's and other dementias to triple by 2050 3 September 2015, University of Sydney
https://www.sydney.edu.au/news-opinion/news/2015/09/03/the-dementia-tsunami--alzheimer-s-disease-and-other-dementias-ex.html
203. Riley RJ, Burgener S, Buckwalter KC. Anxiety and stigma in dementia: a threat to aging in place. Nurs Clin North Am. 2014 Jun;49(2):213-31. doi: 10.1016/j.cnur.2014.02.008. PMID: 24846469; PMCID: PMC4032087.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4032087/
204. Fear of Alzheimer's disease in the French population: impact of age and proximity to the disease Cantegreil-Kallen, Inge et al. International Psychogeriatrics, Volume 24, Issue 1, 108 - 116
https://www.intpsychogeriatrics.org/article/S1041-6102(24)02120-3/fulltext
205. (2014), 2014 Alzheimer's disease facts and figures. Alzheimer's & Dementia, 10: e47-e92. https://doi.org/10.1016/j.jalz.2014.02.001
https://alz-journals.onlinelibrary.wiley.com/doi/10.1016/j.jalz.2014.02.001
206. Watson R, Sanson-Fisher R, Bryant J, Mansfield E. Dementia is the second most feared condition among Australian health service consumers: results of a cross-sectional survey. BMC Public Health. 2023 May 12;23(1):876. doi: 10.1186/s12889-023-15772-y. PMID: 37173717; PMCID: PMC10176813.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10176813/
207. Fear of diseases among people over 50 years of age: A survey, Martin Bystad, Ole Grønli, Camilla Lilleeggen & Per M. Aslaksen Last updated: 16.11.19 Published: 11.12.16, Psykologisk.no
https://psykologisk.no/sp/2016/12/e19/
208. Dementia ‘more feared than cancer’ by older patients 04 August, 2014 By The Press Association, Nursing Times
https://www.nursingtimes.net/older-peoples-nursing/dementia-more-feared-than-cancer-by-older-patients-04-08-2014/
209. Over half of people fear dementia diagnosis, 62 per cent think it means 'life is over' Friday 13 May 2016, Alzheimer's Society
https://www.alzheimers.org.uk/news/2024-11-22/over-half-people-fear-dementia-diagnosis-62-cent-think-it-means-life-over
210. The later stage of dementia, Alzheimer's Society,
https://www.alzheimers.org.uk/about-dementia/symptoms-and-diagnosis/how-dementia-progresses/later-stages-dementia
211. Phillips, J.M.; Ooi, S.L.; Pak, S.C. Health-Promoting Properties of Medicinal Mushrooms and Their Bioactive Compounds for the COVID-19 Era—An Appraisal: Do the Pro-Health Claims Measure Up? Molecules 2022, 27, 2302. https://doi.org/10.3390/molecules27072302
https://www.mdpi.com/1420-3049/27/7/2302
212. Mahmood F, Hetland G, Nentwich I, et al. <i>Agaricus blazei</i>-Based Mushroom Extract Supplementation to Birch Allergic Blood Donors: A Randomized Clinical Trial. Nutrients. 2019 Oct;11(10):E2339. DOI: 10.3390/nu11102339. PMID: 31581605; PMCID: PMC6836217.
https://europepmc.org/article/MED/31581605
213. Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E. Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, on Symptoms, Fatigue and Quality of Life in Patients with Ulcerative Colitis in a Randomized Single-Blinded Placebo Controlled Study. Plos one. 2016 ;11(3):e0150191. DOI: 10.1371/journal.pone.0150191. PMID: 26933886; PMCID: PMC4774976.
https://europepmc.org/article/MED/26933886
214. Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E. Effect of the Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSanTM, on Symptoms, Fatigue and Quality of Life in Patients with Crohn's Disease in a Randomized Single-Blinded Placebo Controlled Study. PLoS One. 2016 Jul 14;11(7):e0159288. doi: 10.1371/journal.pone.0159288. PMID: 27415795; PMCID: PMC4944955.
https://europepmc.org/article/MED/27415795
215. Cytokine Levels After Consumption of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, in Patients with Crohn's Disease and Ulcerative Colitis in a Randomized Single-Blinded Placebo-Controlled Study S. P. Therkelsen, G. Hetland, T. Lyberg, I. Lygren, E. Johnson
https://onlinelibrary.wiley.com/doi/10.1111/sji.12476
216. Tangen JM, Tierens A, Caers J, Binsfeld M, Olstad OK, Trøseid AM, Wang J, Tjønnfjord GE, Hetland G. Immunomodulatory effects of the Agaricus blazei Murrill-based mushroom extract AndoSan in patients with multiple myeloma undergoing high dose chemotherapy and autologous stem cell transplantation: a randomized, double blinded clinical study. Biomed Res Int. 2015;2015:718539. doi: 10.1155/2015/718539. Epub 2015 Jan 18. PMID: 25664323; PMCID: PMC4312620.
https://pubmed.ncbi.nlm.nih.gov/25664323/
217. Hetland, Geir. (2015). Andosan?-An Anti-Allergic and Anti-Inflammatory Ingredient Prepared from Agaricus blazei Mushroom. Journal of Clinical and Cellular Immunology. 06. 10.4172/2155-9899.1000320.
https://www.researchgate.net/publication/277886112_Andosan-An_Anti-Allergic_and_Anti-Inflammatory_Ingredient_Prepared_from_Agaricus_blazei_Mushroom
218. Song HN. Functional Cordyceps Coffee Containing Cordycepin and β-Glucan. Prev Nutr Food Sci. 2020 Jun 30;25(2):184-193. doi: 10.3746/pnf.2020.25.2.184. PMID: 32676470; PMCID: PMC7333010.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7333010/
219. Should you switch to mushroom coffee?, August 7, 2023, UCLA
https://www.uclahealth.org/news/article/should-you-switch-mushroom-coffee
220. Mushroom coffee: Worth a taste? June 4, 2024 By Lindsay Warner, Content Licensing Editor, Harvard Health Publishing
https://www.health.harvard.edu/nutrition/mushroom-coffee-worth-a-taste
221. August 14, 2024 Mushroom Coffee: An Evidence-Based Review Written By Megan Giec Perry PA-C
https://www.rupahealth.com/post/mushroom-coffee-an-evidence-based-review
222. Public Notification: Lishou Slimming Coffee contains hidden drug ingredients, FDA,
https://www.fda.gov/drugs/medication-health-fraud/public-notification-lishou-slimming-coffee-contains-hidden-drug-ingredients
223. Medsafe is issuing a warning that Valentus SlimROAST Optimum Dark Roast Coffee should not be consumed – statement under section 98 of the Medicines Act 1981 11 October 2019
https://www.medsafe.govt.nz/safety/Alerts/ValentusSlimRoast.asp
224. Sachchida Nand Rai, Divya Mishra, Payal Singh, Emanuel Vamanu, M.P. Singh, Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases, Biomedicine & Pharmacotherapy, Volume 137, 2021, 111377, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2021.111377.
https://www.sciencedirect.com/science/article/pii/S0753332221001621
225. Phan CW, David P, Naidu M, Wong KH, Sabaratnam V. Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism. Crit Rev Biotechnol. 2015;35(3):355-68. doi: 10.3109/07388551.2014.887649. PMID: 24654802.
https://pubmed.ncbi.nlm.nih.gov/24654802/
226. Kim-McManus O, Boylan S, Nespeca M. Serendipity Can Rule the Day: Remarkable Efficacy of a Mushroom Extract Powder in Childhood Treatment-Resistant Epilepsy. Pediatr Neurol. 2025 Apr;165:56-59. doi: 10.1016/j.pediatrneurol.2025.01.017. Epub 2025 Jan 24. PMID: 39951934.
https://pubmed.ncbi.nlm.nih.gov/39951934/
227. Ganesan K, Xu B. Anti-Obesity Effects of Medicinal and Edible Mushrooms. Molecules. 2018 Nov 5;23(11):2880. doi: 10.3390/molecules23112880. PMID: 30400600; PMCID: PMC6278646.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6278646/
228. Precious U. Ezurike, Evelyn Odunola, Tolulope A. Oke, Adewale G. Bakre, Oluwayimika Olumide, OgoOluwa Odetoye, Adenike M. Alege, Oyindamola O. Abiodun, Ganoderma lucidum ethanol extract promotes weight loss and improves depressive-like behaviors in male and female Swiss mice, Physiology & Behavior, Volume 265, 2023, 114155, ISSN 0031-9384, https://doi.org/10.1016/j.physbeh.2023.114155.
https://www.sciencedirect.com/science/article/abs/pii/S0031938423000835
229. Eshita Sharma, Rakesh Bairwa, Priyanka Lal, Sudeepta Pattanayak, Kota Chakrapani, Rajendra Poorvasandhya, Awadhesh Kumar, Muhammad Ahsan Altaf, Rahul Kumar Tiwari, Milan Kumar Lal, Ravinder Kumar, Edible mushrooms trending in food: Nutrigenomics, bibliometric, from bench to valuable applications, Heliyon, Volume 10, Issue 17, 2024, e36963, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2024.e36963.
https://www.sciencedirect.com/science/article/pii/S2405844024129945
230. Choi WS, Kim YS, Park BS, Kim JE, Lee SE. Hypolipidaemic Effect of Hericium erinaceum Grown in Artemisia capillaris on Obese Rats. Mycobiology. 2013 Jun;41(2):94-9. doi: 10.5941/MYCO.2013.41.2.94. Epub 2013 Jun 30. PMID: 23874132; PMCID: PMC3714447.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3714447/
231. Grozier CD, Alves VA, Killen LG, Simpson JD, O'Neal EK, Waldman HS. Four Weeks of Hericium erinaceus Supplementation Does Not Impact Markers of Metabolic Flexibility or Cognition. Int J Exerc Sci. 2022 Oct 1;15(2):1366-1380. doi: 10.70252/XZKO8571. PMID: 36582308; PMCID: PMC9762243.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9762243/
232. Teja KS, Suruchi, Rai U, Kumar M, Mohanty O, Roy J, Meshram S. Mushrooms: A Potential Option in the Management of Deficiency and Diseases in Humans. J Pure Appl Microbiol. 2023;17(2):749-760. doi: 10.22207/JPAM.17.2.55
https://microbiologyjournal.org/mushrooms-a-potential-option-in-the-management-of-deficiency-and-diseases-in-humans/
233. Volume 1, Issue 2 (November 2022), Health Science Monitor 2022, 1(2): 107-108 Does Ganoderma lucidum reduce obesity? Ameneh Marzban , Abdolrazagh Marzban , Payam Emami * Department of Emergency Medical Sciences, School of Paramedical Sciences, Kurdistan University of Medical Sciences, Sanandaj, Iran
https://hsm.umsu.ac.ir/browse.php?a_id=46&sid=1&slc_lang=en
234. Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan, Xuefei Yang, A concise review of mushrooms antiviral and immunomodulatory properties that may combat against COVID-19, Food Chemistry Advances, Volume 1, 2022, 100023, ISSN 2772-753X, https://doi.org/10.1016/j.focha.2022.100023.
https://www.sciencedirect.com/science/article/pii/S2772753X22000120
235. Ruth W. Mwangi, John M. Macharia, Isabel N. Wagara, Raposa L. Bence, The antioxidant potential of different edible and medicinal mushrooms, Biomedicine & Pharmacotherapy, Volume 147, 2022, 112621, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2022.112621.
https://www.sciencedirect.com/science/article/pii/S0753332222000099
236. Elsayed EA, El Enshasy H, Wadaan MA, Aziz R. Mushrooms: a potential natural source of anti-inflammatory compounds for medical applications. Mediators Inflamm. 2014;2014:805841. doi: 10.1155/2014/805841. Epub 2014 Nov 23. PMID: 25505823; PMCID: PMC4258329.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4258329/
237. Manna P, Jain SK. Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies. Metab Syndr Relat Disord. 2015 Dec;13(10):423-44. doi: 10.1089/met.2015.0095. PMID: 26569333; PMCID: PMC4808277.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4808277/
238. Theresa V. Rohm, Daniel T. Meier, Jerrold M. Olefsky, Marc Y. Donath, Inflammation in obesity, diabetes, and related disorders, Immunity, Volume 55, Issue 1, 2022, Pages 31-55, ISSN 1074-7613, https://doi.org/10.1016/j.immuni.2021.12.013.
https://www.sciencedirect.com/science/article/pii/S1074761321005495
239. Bilal, Ahmad & Wani, Bilal & Bodha, R & Wani, Ab. Hamid. (2010). Nutritional and medicinal importance of mushrooms. Journal of Medicinal Plants Research. 4. 10.5897/JMPR09.565.
https://www.researchgate.net/publication/266012160_Nutritional_and_medicinal_importance_of_mushrooms
240. Holmes, D. Medicinal mushroom reduces obesity by modulating microbiota. Nat Rev Endocrinol 11, 504 (2015). https://doi.org/10.1038/nrendo.2015.114
https://www.nature.com/articles/nrendo.2015.114#citeas
241. Stamatia-Angeliki Kleftaki, Stamatia Simati, Charalampia Amerikanou, Aristea Gioxari, Chara Tzavara, Georgios I. Zervakis, Nick Kalogeropoulos, Alexander Kokkinos, Andriana C. Kaliora, Pleurotus eryngii improves postprandial glycaemia, hunger and fullness perception, and enhances ghrelin suppression in people with metabolically unhealthy obesity, Pharmacological Research, Volume 175, 2022, 105979, ISSN 1043-6618, https://doi.org/10.1016/j.phrs.2021.105979.
https://www.sciencedirect.com/science/article/abs/pii/S1043661821005636
242. Németh, Z.; Paulinné Bukovics, M.; Sümegi, L.D.; Sturm, G.; Takács, I.; Simon-Szabó, L. The Importance of Edible Medicinal Mushrooms and Their Potential Use as Therapeutic Agents Against Insulin Resistance. Int. J. Mol. Sci. 2025, 26, 827. https://doi.org/10.3390/ijms26020827
https://www.mdpi.com/1422-0067/26/2/827
243. Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, Ohnuki K. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res. 2010 Aug;31(4):231-7. doi: 10.2220/biomedres.31.231. PMID: 20834180.
https://pubmed.ncbi.nlm.nih.gov/20834180/
244. Son EH, Jung DH, Shin H, Lee S, Kim Y, Lim HS. Effects of the Intestinal Status and Clinical Factors of Korean Middle-Aged People Through the Consumption of Functional Foods Containing Auricularia auricula-judae Powder: Prospective, Randomized, Open-Label, and Control Comparative Trial. Clin Nutr Res. 2025 Jan 22;14(1):7-16. doi: 10.7762/cnr.2025.14.1.7. PMID: 39968271; PMCID: PMC11832288.
https://pubmed.ncbi.nlm.nih.gov/39968271/
245. Nutrients. 2021 Mar 21;13(3):1008. doi: 10.3390/nu13031008. Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study Xiao-Qian Xie, Yan Geng, Qijie Guan, Yilin Ren, Lin Guo, Qiqi Lv, Zhen-Ming Lu, Jin-Song Shi, Zheng-Hong Xu.
https://pubmed.ncbi.nlm.nih.gov/33800983/
246. Gut microbiome makeup can determine ability to lose weight, UCLA Health, November 24, 2021
https://www.uclahealth.org/news/article/gut-microbiome-makeup-can-determine-ability-to-lose-weight
247. Jian, C., Silvestre, M.P., Middleton, D. et al. Gut microbiota predicts body fat change following a low-energy diet: a PREVIEW intervention study. Genome Med 14, 54 (2022). https://doi.org/10.1186/s13073-022-01053-7
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-022-01053-7
248. Małgorzata Moszak, Marta Pelczyńska, Agnieszka Wesołek, Dominika Stenclik, Paweł Bogdański, Does gut microbiota affect the success of weight loss? Evidence and speculation, Nutrition, Volume 116, 2023, 112111, ISSN 0899-9007, https://doi.org/10.1016/j.nut.2023.112111.
https://www.sciencedirect.com/science/article/pii/S0899900723001405
249. Li, H., Zhang, L., Li, J. et al. Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota. Nat Metab 6, 578–597 (2024). https://doi.org/10.1038/s42255-024-00988-y
https://www.nature.com/articles/s42255-024-00988-y
250. Hearing Loss & Tinnitus Statistics, Hearing Health Foundation
https://hearinghealthfoundation.org/hearing-loss-tinnitus-statistics
251. Int J Med Mushrooms, 19 (4), 279-317 2017 Medicinal Mushrooms in Human Clinical Studies. Part I. Anticancer, Oncoimmunological, and Immunomodulatory Activities: A Review Solomon P Wasser
https://pubmed.ncbi.nlm.nih.gov/28605319
252. Biomed J, 37 (6), 345-56 Nov-Dec 2014 Medicinal Mushroom Science: Current Perspectives, Advances, Evidences, and Challenges Solomon P Wasser
https://pubmed.ncbi.nlm.nih.gov/25179726
253. Karthiyayini Balakrishnan, Sanjushree Nagarajan, Gowdhami Balakrishnan, Muthuselvam Manickam, Dhanasekaran Dharumadurai, Chapter 15 - Symbiotic microbial interactions in medicinal mushroom: an insight of phenotypic and genotypic characterization methods, Editor(s): Dhanasekaran Dharumadurai, In Developments in Applied Microbiology and Biotechnology, Microbial Symbionts, Academic Press, 2023, Pages 277-294, ISBN 9780323993340
https://www.sciencedirect.com/topics/immunology-and-microbiology/medicinal-mushroom
254. Fungi as Future Medicine: The Therapeutic Potential of Mushrooms, Dr. Sanchari Sinha Dutta, Ph.D., News-Medical.Net ,
https://www.news-medical.net/health/Fungi-as-Future-Medicine-The-Therapeutic-Potential-of-Mushrooms.aspx
255. Chemical and Pharmacological Investigations of Fomitopsis betulina (formerly: Piptoporus betulinus) and Calvatia gigantea, Inauguraldissertation zur Erlangung des akademischen Grades doctor rerum naturalium (Dr. rer. nat.) an der Mathematisch-Naturwissenschaftlichen Fakultät der Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Februar 2019
https://epub.ub.uni-greifswald.de/frontdoor/deliver/index/docId/3477/file/Dissertation-Alresly.pdf
256. Wasser, Solomon. (2017). Medicinal Properties and Clinical Effects of Medicinal Mushrooms: Technology and Applications. 10.1002/9781119149446.ch22.
https://www.researchgate.net/publication/319118336_Medicinal_Properties_and_Clinical_Effects_of_Medicinal_Mushrooms_Technology_and_Applications
257. Jia L-F, Chen P, Qu G-D, et al. A comprehensive review of the sedative-hypnotic mechanisms of edible fungi. Food & Medicine Homology, 2025, https://doi.org/10.26599/FMH.2025.9420049
https://www.sciopen.com/article/10.26599/FMH.2025.9420049
258. Wei Chen, Jun-Wen Yu, Yu-Yi Deng, Lut Yi Wong, Chen Wang, Yu-Ling Liang, Yuk-Tung Leung, Jia-Yi Tian, Ying Wu, Kelvin Sze-Yin Leung, Jinhui Hu, Wen-Hua Chen, Xiaobing Dou, Xiu-Qiong Fu, Ying-Jie Chen, Zhi-Ling Yu, Identification of sedative-hypnotic compounds shared by five medicinal Polyporales mushrooms using UPLC-Q-TOF-MS/MS-based untargeted metabolomics, Phytomedicine, Volume 128, 2024, 155355, ISSN 0944-7113, https://doi.org/10.1016/j.phymed.2024.155355.
https://www.sciencedirect.com/science/article/abs/pii/S0944711324000205
259. Tselepis, George & Palamiotis, Ioannis & Georgiou, Sofia. (2023). Homeostasis of Circadian Rhythm and Therapeutic Approaches to Manage its Related-Disorders: The Case of Medicinal Mushrooms Rich in Melatonin. Med Discoveries. 2. 10.52768/2993-1142/1075.
https://www.researchgate.net/publication/375439212_Homeostasis_of_Circadian_Rhythm_and_Therapeutic_Approaches_to_Manage_its_Related-Disorders_The_Case_of_Medicinal_Mushrooms_Rich_in_Melatonin
260. Lu J, Su M, Zhou X, Li D, Niu X, Wang Y. Research Progress of Bioactive Components in Sanghuangporus spp. Molecules. 2024 Mar 7;29(6):1195. doi: 10.3390/molecules29061195. PMID: 38542832; PMCID: PMC10976032.
https://pubmed.ncbi.nlm.nih.gov/38542832/
261. Yao L, Lv J, Duan C, An X, Zhang C, Li D, Li C, Liu S. Armillaria mellea fermentation liquor ameliorates p-chlorophenylalanine-induced insomnia associated with the modulation of serotonergic system and gut microbiota in rats. J Food Biochem. 2022 Feb;46(2):e14075. doi: 10.1111/jfbc.14075. Epub 2022 Jan 5. PMID: 34984694.
https://pubmed.ncbi.nlm.nih.gov/34984694/
262. Sharma H, Sharma N, An SSA. Unique Bioactives from Zombie Fungus (Cordyceps) as Promising Multitargeted Neuroprotective Agents. Nutrients. 2023 Dec 27;16(1):102. doi: 10.3390/nu16010102. PMID: 38201932; PMCID: PMC10780653.
https://pubmed.ncbi.nlm.nih.gov/38201932/
263. Tan YF, Mo JS, Wang YK, Zhang W, Jiang YP, Xu KP, Tan GS, Liu S, Li J, Wang WX. The ethnopharmacology, phytochemistry and pharmacology of the genus Hericium. J Ethnopharmacol. 2024 Jan 30;319(Pt 3):117353. doi: 10.1016/j.jep.2023.117353. Epub 2023 Oct 29. PMID: 37907145.
https://pubmed.ncbi.nlm.nih.gov/37907145/
264. Published April 20, 2009 COMPLEMENTARY and ALTERNATIVE MEDICINE Adaptogenic or Medicinal Mushrooms M. Saljoughian, PharmD, PhD
https://www.uspharmacist.com/article/adaptogenic-or-medicinal-mushrooms
265. Yao, C., Wang, Z., Jiang, H. et al. Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice. Sci Rep 11, 13660 (2021). https://doi.org/10.1038/s41598-021-92913-6
https://www.nature.com/articles/s41598-021-92913-6
266. Batra P, Sharma AK, Khajuria R. Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. Int J Med Mushrooms. 2013;15(2):127-43. doi: 10.1615/intjmedmushr.v15.i2.20. PMID: 23557365.
https://pubmed.ncbi.nlm.nih.gov/23557365/
267. Lee KH, Morris-Natschke SL, Yang X, Huang R, Zhou T, Wu SF, Shi Q, Itokawa H. Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine. J Tradit Complement Med. 2012 Apr;2(2):84-95. PMID: 24716120; PMCID: PMC3942920.
https://core.ac.uk/download/pdf/82062841.pdf
268. Reishi Cultivation The mushroom of immortality, Michael den Herder, European Forest Institute, [email protected] April 2022
https://efi.int/sites/default/files/files/knowledge/projects/EFI_Reishi_Cultivation_EN.pdf
269. Sanodiya BS, Thakur GS, Baghel RK, Prasad GB, Bisen PS. Ganoderma lucidum: a potent pharmacological macrofungus. Curr Pharm Biotechnol. 2009 Dec;10(8):717-42. doi: 10.2174/138920109789978757. PMID: 19939212.
https://pubmed.ncbi.nlm.nih.gov/19939212/
270. Yao C, Wang Z, Jiang H, Yan R, Huang Q, Wang Y, Xie H, Zou Y, Yu Y, Lv L. Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice. Sci Rep. 2021 Jul 1;11(1):13660. doi: 10.1038/s41598-021-92913-6. PMID: 34211003; PMCID: PMC8249598.
https://pubmed.ncbi.nlm.nih.gov/34211003/
271. Xiang-Yu Cui, Su-Ying Cui, Juan Zhang, Zi-Jun Wang, Bin Yu, Zhao-Fu Sheng, Xue-Qiong Zhang, Yong-He Zhang, Extract of Ganoderma lucidum prolongs sleep time in rats, Journal of Ethnopharmacology, Volume 139, Issue 3, 2012, Pages 796-800, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2011.12.020.
https://www.sciencedirect.com/science/article/abs/pii/S0378874111008981
272. Angelini, Paola & Girometta, Carolina & Venanzoni, Roberto & Bertuzzi, Gianluigi. (2022). Anti-Aging Properties of Medicinal Mushrooms in Systemic Aesthetic Medicine. 10.1007/978-981-16-6257-7_7.
https://www.researchgate.net/publication/359317471_Anti-Aging_Properties_of_Medicinal_Mushrooms_in_Systemic_Aesthetic_Medicine
273. Kumar, Nanjangud & Quispe, Cristina & Herrera, Jesús & Herrera Belén, Lisandra & Loren Reyes, Pía & Salazar, Luis & Silva, Victor & Orhan, Ilkay & Senol Deniz, Fatma & Nemli, Elifsu & Capanoglu, Esra & Olatunde, Ahmed & Silva, Nathalia & Živković, Jelena & Shorog, Eman & Calina, Daniela & Sharifi-Rad, Javad. (2023). Potential of Mushrooms Bioactive for the Treatment of Skin Diseases and Disorders. Journal of Food Biochemistry. 2023. 1-26. 10.1155/2023/5915769.
https://www.researchgate.net/publication/376450794_Potential_of_Mushrooms_Bioactive_for_the_Treatment_of_Skin_Diseases_and_Disorders
274. Fordjour E, Manful CF, Javed R, Galagedara LW, Cuss CW, Cheema M, Thomas R. Chaga mushroom: a super-fungus with countless facets and untapped potential. Front Pharmacol. 2023 Dec 5;14:1273786. doi: 10.3389/fphar.2023.1273786. PMID: 38116085; PMCID: PMC10728660.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10728660/
275. Burlec, A.F.; Hăncianu, M.; Ivănescu, B.; Macovei, I.; Corciovă, A. Exploring the Therapeutic Potential of Natural Compounds in Psoriasis and Their Inclusion in Nanotechnological Systems. Antioxidants 2024, 13, 912. https://doi.org/10.3390/antiox13080912
https://www.mdpi.com/2076-3921/13/8/912
276. personal care, skin diseases Psoriasis – Plant-based Approach to Strengthen the Skin’s Immune System S. Hettwer, E. Besic Gyenge, B. Suter, B. Obermayer
https://www.rahn-group.com/en/rahn/download-document/845ab00f-9b60-4457-8f65-4162f5f81add/pd_literature_liftonin-qi_techpaper_sofw_2206_enp001621675.pdf
277. What are the benefits of lion’s mane mushrooms? Medically reviewed by Kim Rose-Francis RDN, CDCES, LD, Nutrition — Written by Jayne Leonard — Updated on December 10, 2024
https://www.medicalnewstoday.com/articles/323400
278. Németh, Z.; Paulinné Bukovics, M.; Sümegi, L.D.; Sturm, G.; Takács, I.; Simon-Szabó, L. The Importance of Edible Medicinal Mushrooms and Their Potential Use as Therapeutic Agents Against Insulin Resistance. Int. J. Mol. Sci. 2025, 26, 827. https://doi.org/10.3390/ijms26020827
https://www.mdpi.com/1422-0067/26/2/827
279. Kiho T, Yamane A, Hui J, Usui S, Ukai S. Polysaccharides in fungi. XXXVI. Hypoglycemic activity of a polysaccharide (CS-F30) from the cultural mycelium of Cordyceps sinensis and its effect on glucose metabolism in mouse liver. Biol Pharm Bull. 1996 Feb;19(2):294-6. doi: 10.1248/bpb.19.294. PMID: 8850325.
https://www.jstage.jst.go.jp/article/bpb1993/19/2/19_2_294/_article
280. Hypolipidemic effect of exo- and endo-biopolymers produced from submerged mycelial culture of Ganoderma lucidum in rats By: Yang, Byung-Keun Journal of Microbiology and Biotechnology (2002), 12(6), 872-877 CODEN: JOMBES; ISSN: 1017-7825
https://chemport-n.cas.org//chemport-n/?APP=ftslink&action=reflink&origin=npg&version=1.0&coi=1%3ACAS%3A528%3ADC%2BD3sXhvVyrs7s%3D&md5=81df50e26d135d0e7d203517b6259c6e
281. L. Liang, Z. Zhang, W. Sun and Y. Wang, "Effect of the Inonotus Obliquus Polysaccharides on Blood Lipid Metabolism and Oxidative Stress of Rats Fed High-Fat Diet In Vivo," 2009 2nd International Conference on Biomedical Engineering and Informatics, Tianjin, China, 2009, pp. 1-4, doi: 10.1109/BMEI.2009.5305591.
https://ieeexplore.ieee.org/document/5305591
282. Kim, SY., Chung, SI., Nam, SH. et al. Cholesterol lowering action and antioxidant status improving efficacy of noodles made from unmarketable oak mushroom (Lentinus edodes) in high cholesterol fed rats. J. Korean Soc. Appl. Biol. Chem. 52, 207–212 (2009). https://doi.org/10.3839/jksabc.2009.038
https://applbiolchem.springeropen.com/articles/10.3839/jksabc.2009.038#citeas
283. Hiwatashi K, Kosaka Y, Suzuki N, Hata K, Mukaiyama T, Sakamoto K, Shirakawa H, Komai M. Yamabushitake mushroom (Hericium erinaceus) improved lipid metabolism in mice fed a high-fat diet. Biosci Biotechnol Biochem. 2010;74(7):1447-51. doi: 10.1271/bbb.100130. Epub 2010 Jul 7. PMID: 20622452.
https://pubmed.ncbi.nlm.nih.gov/20622452/
284. Handayani, Dian & Chen, J & Meyer, B & Huang, Xu-Feng. (2011). Dietary Shiitake Mushroom (Lentinus edodes) Prevents Fat Deposition and Lowers Triglyceride in Rats Fed a High-Fat Diet. Journal of obesity. 2011. 258051. 10.1155/2011/258051.
https://www.researchgate.net/publication/51746881_Dietary_Shiitake_Mushroom_Lentinus_edodes_Prevents_Fat_Deposition_and_Lowers_Triglyceride_in_Rats_Fed_a_High-Fat_Diet
285. Choi WS, Kim YS, Park BS, Kim JE, Lee SE. Hypolipidaemic Effect of Hericium erinaceum Grown in Artemisia capillaris on Obese Rats. Mycobiology. 2013 Jun;41(2):94-9. doi: 10.5941/MYCO.2013.41.2.94. Epub 2013 Jun 30. PMID: 23874132; PMCID: PMC3714447.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3714447/
286. Henriques, Gilberto & Helm, Cristiane & Busato, Ana & Simeone, Maria. (2016). Lipid profile and glycemic response of rats fed on a semi-purified diet supplemented with Agaricus brasiliensis mushroom. Acta Scientiarum. Health Sciences. 38. 71. 10.4025/actascihealthsci.v38i1.29185.
https://www.redalyc.org/journal/3072/307245984010/html/
287. Anwar H, Suchodolski JS, Ullah MI, Hussain G, Shabbir MZ, Mustafa I, Sohail MU. Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Supplementation Alters Gut Microbiome and Corrects Dyslipidemia in Rats. Int J Med Mushrooms. 2019;21(1):79-88. doi: 10.1615/IntJMedMushrooms.2018029348.
https://qspace.qu.edu.qa/handle/10576/11369?show=full
288. Olaide Olawunmi Ajibola, Cirilo Nolasco-Hipolito, Octavio Carvajal-Zarrabal, Shanti F Salleh, Gbadebo C Adeyinka, Stephen A Adefegha, Mirja K Ahmmed, Kazi Sumaiya, Raymond Thomas, Turkey tail mushroom (Trametes versicolor): an edible macrofungi with immense medicinal properties, Current Opinion in Food Science, Volume 58, 2024, 101191, ISSN 2214-7993, https://doi.org/10.1016/j.cofs.2024.101191.
https://www.sciencedirect.com/science/article/pii/S2214799324000699
289. African Journal of Biotechnology Vol. 5 (13), pp. 1263-1266, 3 July 2006 Available online at http://www.academicjournals.org/AJB ISSN 1684–5315 © 2006 Academic Journals. Responses of plasma lipids to edible mushroom diets in albino rats Oyetayo, F.L Department of Biochemistry, University of Ado-Ekiti, Nigeria. E-mail: [email protected].
https://www.ajol.info/index.php/ajb/article/view/43095
290. alzdiscovery.org. Lion's mane, 8/9/2026
https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Lions-Mane-Cognitive-Vitality-For-Researchers.pdf
291. Samarasinghe, M W A Kanchana Priyadarshani & Waisundara, Viduranga. (2020). Therapeutic Properties and Anti-Lipidemic Activity of Cordyceps sinensis. 10.5772/intechopen.92616.
https://www.intechopen.com/chapters/72232
292. Phillips, J.M.; Ooi, S.L.; Pak, S.C. Health-Promoting Properties of Medicinal Mushrooms and Their Bioactive Compounds for the COVID-19 Era—An Appraisal: Do the Pro-Health Claims Measure Up? Molecules 2022, 27, 2302. https://doi.org/10.3390/ molecules27072302
https://researchoutput.csu.edu.au/ws/portalfiles/portal/347095015/213340870_Published_article.pdf
293. Bhambri A, Srivastava M, Mahale VG, Mahale S and Karn SK (2022) Mushrooms as Potential Sources of Active Metabolites and Medicines. Front. Microbiol. 13:837266. doi: 10.3389/fmicb.2022.837266
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.837266/full
294. Consuming Mushrooms When Adopting a Healthy Mediterranean-Style Dietary Pattern Does Not Influence Short-Term Changes of Most Cardiometabolic Disease Risk Factors in Healthy Middle-Aged and Older Adults Uffelman, Cassi N et al. The Journal of Nutrition, Volume 154, Issue 2, 574 - 582
https://jn.nutrition.org/article/S0022-3166(23)72815-0/fulltext
295. Fritz, H.; Kennedy, D.A.; Ishii, M.; Fergusson, D.; Fernandes, R.; Cooley, K.; Seely, D. Polysaccharide K and Coriolus versicolor Extracts for Lung Cancer. Integr. Cancer Ther. 2015, 14, 201–211.
https://pubmed.ncbi.nlm.nih.gov/25784670/
296. Shahid A, Chen M, Yeung S, Parsa C, Orlando R, Huang Y. The medicinal mushroom Ganoderma lucidum prevents lung tumorigenesis induced by tobacco smoke carcinogens. Front Pharmacol. 2023 Sep 6;14:1244150. doi: 10.3389/fphar.2023.1244150. PMID: 37745066; PMCID: PMC10516555.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10516555/
297. Sangtitanu, T.; Sangtanoo, P.; Srimongkol, P.; Saisavoey, T.; Reamtong, O.; Karnchanatat, A. Peptides obtained from edible mushrooms: Hericium erinaceus offers the ability to scavenge free radicals and induce apoptosis in lung cancer cells in humans. Food Funct. 2020, 11, 4927–4939.
https://pubs.rsc.org/en/content/articlelanding/2020/fo/d0fo00227e/unauth
298. Mihi Yang, Hee-Kyung Jang, Huiwon Kang. How do shiitake and reishi mushrooms work on lung cancer?: A high throughput screening of 3D cell culture. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4553.
https://aacrjournals.org/cancerres/article/83/7_Supplement/4553/724521/Abstract-4553-How-do-shiitake-and-reishi-mushrooms
299. Park, S.E.; Yoo, H.S.; Jin, C.-Y.; Hong, S.H.; Lee, Y.-W.; Kim, B.W.; Lee, S.H.; Kim, W.-J.; Cho, C.K.; Choi, Y.H. Induction of apoptosis and inhibition of telomerase activity in human lung carcinoma cells by the water extract of Cordyceps militaris. Food Chem. Toxicol. 2009, 47, 1667–1675.
https://www.sciencedirect.com/science/article/abs/pii/S0278691509001744
300. Hsu, W.-H.; Qiu, W.-L.; Tsao, S.-M.; Tseng, A.-J.; Lu, M.-K.; Hua, W.-J.; Cheng, H.-C.; Hsu, H.-Y.; Lin, T.-Y. Effects of WSG, a polysaccharide from Ganoderma lucidum, on suppressing cell growth and mobility of lung cancer. Int. J. Biol. Macromol. 2020, 165, 1604–1613.
https://pubmed.ncbi.nlm.nih.gov/33011264/
301. Spandidos Publications style Loganathan J, Jiang J, Smith A, Jedinak A, Thyagarajan-Sahu A, Sandusky GE, Nakshatri H and Sliva D: The mushroom Ganoderma lucidum suppresses breast-to-lung cancer metastasis through the inhibition of pro-invasive genes. Int J Oncol 44: 2009-2015, 2014.
https://www.spandidos-publications.com/10.3892/ijo.2014.2375
302. Lai, Wei & Zainal, Zamri & Daud, Fauzi. (2014). Preliminary study on the potential of polysaccharide from indigenous Tiger's Milk mushroom (Lignosus rhinocerus) as anti-lung cancer agent. 1614. 517-519. 10.1063/1.4895252.
https://www.researchgate.net/publication/299862394_Preliminary_study_on_the_potential_of_polysaccharide_from_indigenous_Tiger%27s_Milk_mushroom_Lignosus_rhinocerus_as_anti-lung_cancer_agent
https://www.spandidos-publications.com/10.3892/ijo.2014.2375
303. Secme M, Kaygusuz O, Eroglu C, Dodurga Y, Colak OF, Atmaca P. Potential Anticancer Activity of the Parasol Mushroom, Macrolepiota procera (Agaricomycetes), against the A549 Human Lung Cancer Cell Line. Int J Med Mushrooms. 2018;20(11):1075-1086. doi: 10.1615/IntJMedMushrooms.2018028589. PMID: 30806231.
https://www.dl.begellhouse.com/journals/708ae68d64b17c52,6e2de2a705b6ffd3,11ce65196897bbc7.html
304. Huo, Xiaowei & Liu, Chenqi & Bai, Xuelian & Li, Wenjia & Li, Jing & Hu, Xuefeng & Cao, Li. (2017). Aqueous extract of Cordyceps sinensis potentiates the antitumor effect of DDP and attenuates therapy-associated toxicity in non-small cell lung cancer via IκBα/NFκB and AKT/MMP2/MMP9 pathways. RSC Adv.. 7. 37743-37754. 10.1039/C7RA04716A.
https://www.researchgate.net/publication/318820879_Aqueous_extract_of_Cordyceps_sinensis_potentiates_the_antitumor_effect_of_DDP_and_attenuates_therapy-associated_toxicity_in_non-small_cell_lung_cancer_via_IkBaNFkB_and_AKTMMP2MMP9_pathways
305. Bizarro A, Ferreira IC, Soković M, van Griensven LJ, Sousa D, Vasconcelos MH, Lima RT. Cordyceps militaris (L.) Link Fruiting Body Reduces the Growth of a Non-Small Cell Lung Cancer Cell Line by Increasing Cellular Levels of p53 and p21. Molecules. 2015 Jul 31;20(8):13927-40. doi: 10.3390/molecules200813927. PMID: 26263965; PMCID: PMC6332316.
https://pubmed.ncbi.nlm.nih.gov/26263965/
306. Khunoana ET, Nkadimeng SM. Current Advances in the Use of Mushrooms as Therapeutics for Lung Cancer: A Review. Molecules. 2025 Mar 14;30(6):1322. doi: 10.3390/molecules30061322. PMID: 40142097; PMCID: PMC11944945.
https://pubmed.ncbi.nlm.nih.gov/40142097/
307. WHO, Cervical cancer 5 March 2024,
https://www.who.int/news-room/fact-sheets/detail/cervical-cancer
308. Jie Wu, Qianyun Jin, Yunmeng Zhang, Yuting Ji, Jingjing Li, Xiaomin Liu, Hongyuan Duan, Zhuowei Feng, Ya Liu, Yacong Zhang, Zhangyan Lyu, Lei Yang, Yubei Huang, Global burden of cervical cancer: current estimates, temporal trend and future projections based on the GLOBOCAN 2022, Journal of the National Cancer Center, 2025, , ISSN 2667-0054, https://doi.org/10.1016/j.jncc.2024.11.006.
https://www.sciencedirect.com/science/article/pii/S2667005425000134
309. Cervical Cancer Leads Cancer Deaths for Women in 37 Countries, July 29, 2024 Sandy McDowell | Managing Editor Research Written by: Sandy McDowell Editorial Director, Digital Research Content, American Cancer Society
https://www.cancer.org/research/acs-research-news/cervical-cancer-leads-cancer-deaths-37-countries.html
310. Okunade KS. Human papillomavirus and cervical cancer. J Obstet Gynaecol. 2020 Jul;40(5):602-608. doi: 10.1080/01443615.2019.1634030. Epub 2019 Sep 10. Erratum in: J Obstet Gynaecol. 2020 May;40(4):590. doi: 10.1080/01443615.2020.1713592. PMID: 31500479; PMCID: PMC7062568.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7062568/
311. Medicinal Mushrooms (PDQ®)–Health Professional Version, National Cancer Institute
https://www.cancer.gov/about-cancer/treatment/cam/hp/mushrooms-pdq
312. What Is Stomach Cancer? January 22, 2021 American Cancer Society
https://www.cancer.org/cancer/types/stomach-cancer/about/what-is-stomach-cancer.html
313. Menon G, El-Nakeep S, Babiker HM. Gastric Cancer. [Updated 2024 Oct 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK459142/
314. Zaręba KP, Zińczuk J, Dawidziuk T, Pryczynicz A, Guzińska-Ustymowicz K, Kędra B. Stomach cancer in young people - a diagnostic and therapeutic problem. Prz Gastroenterol. 2019;14(4):283-285. doi: 10.5114/pg.2019.90254. Epub 2019 Dec 20. PMID: 31988675; PMCID: PMC6983757.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6983757/
315. Zhang H, Yang W, Tan X, He W, Zhao L, Liu H, Li G. Long-term relative survival of patients with gastric cancer from a large-scale cohort: a period-analysis. BMC Cancer. 2024 Nov 18;24(1):1420. doi: 10.1186/s12885-024-13141-5. PMID: 39558281; PMCID: PMC11571998.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11571998/
316. Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Prz Gastroenterol. 2019;14(2):89-103. doi: 10.5114/pg.2018.81072. Epub 2019 Jan 6. PMID: 31616522; PMCID: PMC6791134.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6791134/
317. Leon Klimeck, Thomas Heisser, Michael Hoffmeister, Hermann Brenner, Colorectal cancer: A health and economic problem, Best Practice & Research Clinical Gastroenterology, Volume 66, 2023, 101839, ISSN 1521-6918, https://doi.org/10.1016/j.bpg.2023.101839.
https://www.sciencedirect.com/science/article/abs/pii/S1521691823000197
318. Siegel RL, Wagle NS, Cercek A, Smith RA, Jemal A. Colorectal cancer statistics, 2023. CA Cancer J Clin. 2023 May-Jun;73(3):233-254. doi: 10.3322/caac.21772. Epub 2023 Mar 1. PMID: 36856579.
https://pubmed.ncbi.nlm.nih.gov/36856579/
319. Ilyas MIM. Epidemiology of Stage IV Colorectal Cancer: Trends in the Incidence, Prevalence, Age Distribution, and Impact on Life Span. Clin Colon Rectal Surg. 2023 Mar 15;37(2):57-61. doi: 10.1055/s-0043-1761447. PMID: 38322602; PMCID: PMC10843881.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10843881/
320. Mahdy H, Vadakekut ES, Crotzer D. Endometrial Cancer. [Updated 2024 Apr 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK525981/
321. Liu L, Habeshian TS, Zhang J, Peeri NC, Du M, De Vivo I, Setiawan VW. Differential trends in rising endometrial cancer incidence by age, race, and ethnicity. JNCI Cancer Spectr. 2023 Jan 3;7(1):pkad001. doi: 10.1093/jncics/pkad001. PMID: 36625534; PMCID: PMC9904185.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9904185/
322. Spandidos Publications style Hahne JC, Meyer SR, Dietl J and Honig A: The effect of Cordyceps extract and a mixture of Ganoderma lucidum/Agaricus Blazi Murill extract on human endometrial cancer cell lines in vitro. Int J Oncol 45: 373-382, 2014.
https://www.spandidos-publications.com/10.3892/ijo.2014.2414
323. Tsai YT, Kuo PH, Kuo HP, Hsu CY, Lee YJ, Kuo CL, Liu JY, Lee SL, Kao MC. Ganoderma tsugae suppresses the proliferation of endometrial carcinoma cells via Akt signaling pathway. Environ Toxicol. 2021 Mar;36(3):320-327. doi: 10.1002/tox.23037. Epub 2020 Oct 12. PMID: 33044769.
https://pubmed.ncbi.nlm.nih.gov/33044769/
324. Shi M. The Efficacy of Ganoderma lucidum Extracts on Treating Endometrial Cancer: A Network Pharmacology Approach. Reprod Sci. 2024 Jul;31(7):1881-1894. doi: 10.1007/s43032-024-01500-3. Epub 2024 Mar 6. PMID: 38448739; PMCID: PMC11217070.
https://pubmed.ncbi.nlm.nih.gov/38448739/
325. What Are Polyps and Adenomas? University of Rochester Medical Center
https://www.urmc.rochester.edu/conditions-and-treatments/polyps-and-adenomas
326. Adrian C. Bateman, Pathology of colorectal polyps and cancer, Surgery (Oxford), Volume 41, Issue 1, 2023, Pages 15-21, ISSN 0263-9319, https://doi.org/10.1016/j.mpsur.2022.10.011.
https://www.sciencedirect.com/science/article/abs/pii/S0263931922002101
327. Conteduca V, Sansonno D, Russi S, Dammacco F. Precancerous colorectal lesions (Review). Int J Oncol. 2013 Oct;43(4):973-84. doi: 10.3892/ijo.2013.2041. Epub 2013 Jul 29. PMID: 23900573.
https://pubmed.ncbi.nlm.nih.gov/23900573/
328. Munding J, Tannapfel A. Epidemiology of Colorectal Adenomas and Histopathological Assessment of Endoscopic Specimens in the Colorectum. Viszeralmedizin. 2014 Feb;30(1):10-6. doi: 10.1159/000357744. PMID: 26288577; PMCID: PMC4513795.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4513795/
329. https://www.nature.com/articles/s41572-020-00240-3
Llovet, J.M., Kelley, R.K., Villanueva, A. et al. Hepatocellular carcinoma. Nat Rev Dis Primers 7, 6 (2021). https://doi.org/10.1038/s41572-020-00240-3
330. Asafo-Agyei KO, Samant H. Hepatocellular Carcinoma. [Updated 2023 Jun 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK559177/
331. Huitzil-Melendez FD, Capanu M, O'Reilly EM, Duffy A, Gansukh B, Saltz LL, Abou-Alfa GK. Advanced hepatocellular carcinoma: which staging systems best predict prognosis? J Clin Oncol. 2010 Jun 10;28(17):2889-95. doi: 10.1200/JCO.2009.25.9895. Epub 2010 May 10. PMID: 20458042; PMCID: PMC3651603.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3651603/
332. Alves, Rogério & Alves, Daniele & Guz, Betty & Matos, Carla & Viana, Monica & Harriz, Michelle & Terrabuio, Deborah & Kondo, Mario & Gampel, Otávio & Polletti, Paula. (2011). Advanced hepatocellular carcinoma. Review of targeted molecular drugs. Annals of hepatology. 10. 21-7. 10.1016/S1665-2681(19)31582-0.
https://www.elsevier.es/en-revista-annals-hepatology-16-articulo-advanced-hepatocellular-carcinoma-review-targeted-S1665268119315820
333. Kim DW, Talati C, Kim R. Hepatocellular carcinoma (HCC): beyond sorafenib—chemotherapy. J Gastrointest Oncol 2017;8(2):256-265. doi: 10.21037/jgo.2016.09.07
https://jgo.amegroups.org/article/view/9549/html
334. Deng GL, Zeng S, Shen H. Chemotherapy and target therapy for hepatocellular carcinoma: New advances and challenges. World J Hepatol. 2015 Apr 18;7(5):787-98. doi: 10.4254/wjh.v7.i5.787. PMID: 25914779; PMCID: PMC4404384.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4404384/
335. W. Yeo, F.K.F. Mo, J. Koh, A.T.C. Chan, T. Leung, P. Hui, L. Chan, A. Tang, J.J. Lee, T.S.K. Mok, P.B.S. Lai, P.J. Johnson, B. Zee, Quality of life is predictive of survival in patients with unresectable hepatocellular carcinoma, Annals of Oncology, Volume 17, Issue 7, 2006, Pages 1083-1089, ISSN 0923-7534, https://doi.org/10.1093/annonc/mdl065.
https://www.sciencedirect.com/science/article/pii/S0923753419453751
336. Kennedy, A.S., Sangro, B. Nonsurgical Treatment for Localized Hepatocellular Carcinoma. Curr Oncol Rep 16, 373 (2014). https://doi.org/10.1007/s11912-013-0373-x
https://link.springer.com/article/10.1007/s11912-013-0373-x
337. Thomas W. T. Leung, Yehuda Z. Patt, Wan-yee Lau, Stephen K. W. Ho, Simon C. H. Yu, Anthony T. C. Chan, Tony S. K. Mok, Winnie Yeo, Choong-tsek Liew, Nancy W. Y. Leung, Amanda M. Y. Tang, Philip J. Johnson; Complete Pathological Remission Is Possible with Systemic Combination Chemotherapy for Inoperable Hepatocellular Carcinoma. Clin Cancer Res 1 July 1999; 5 (7): 1676–1681.
https://aacrjournals.org/clincancerres/article/5/7/1676/287579/Complete-Pathological-Remission-Is-Possible-with
338. Agirrezabal, I., Pollock, R.F., Carion, P.L. et al. Association of adverse events and quality of life in patients with unresectable hepatocellular carcinoma. Qual Life Res 33, 3377–3386 (2024). https://doi.org/10.1007/s11136-024-03779-w
https://link.springer.com/article/10.1007/s11136-024-03779-w
339. Gandhi S, Khubchandani S, Iyer R. Quality of life and hepatocellular carcinoma. J Gastrointest Oncol 2014;5(4):296-317. doi: 10.3978/j.issn.2078-6891.2014.046
https://jgo.amegroups.org/article/view/2783/html
340. Pathomjaruwat T, Matchim Y, Armer JM. Symptoms and symptom clusters in patients with hepatocellular carcinoma and commonly used instruments: An integrated review. Int J Nurs Sci. 2023 Sep 21;11(1):66-75. doi: 10.1016/j.ijnss.2023.09.009. PMID: 38352278; PMCID: PMC10859590.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10859590/
341. Christian-Miller N, Frenette C. Hepatocellular cancer pain: impact and management challenges. J Hepatocell Carcinoma. 2018 Jul 19;5:75-80. doi: 10.2147/JHC.S145450. PMID: 30050880; PMCID: PMC6055904.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6055904/
342. Sun VC, Sarna L. Symptom management in hepatocellular carcinoma. Clin J Oncol Nurs. 2008 Oct;12(5):759-66. doi: 10.1188/08.CJON.759-766. PMID: 18842532; PMCID: PMC2881685.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2881685/
343. Ranasinghe IR, Tian C, Hsu R. Crohn Disease. [Updated 2024 Feb 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK436021/
344. Lin, D., Jin, Y., Shao, X. et al. Global, regional, and national burden of inflammatory bowel disease, 1990–2021: Insights from the global burden of disease 2021. Int J Colorectal Dis 39, 139 (2024).https://doi.org/10.1007/s00384-024-04711-x
https://link.springer.com/article/10.1007/s00384-024-04711-x
345. Five Types of Crohn's Disease | North Shore Gastroenterology
https://www.northshoregastro.org/2020/10/16/five-types-of-crohns-disease/
346. Molodecky NA, Kaplan GG. Environmental risk factors for inflammatory bowel disease. Gastroenterol Hepatol (N Y). 2010 May;6(5):339-46. PMID: 20567592; PMCID: PMC2886488.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2886488/
347. Berkowitz L, Schultz BM, Salazar GA, Pardo-Roa C, Sebastián VP, Álvarez-Lobos MM and Bueno SM (2018) Impact of Cigarette Smoking on the Gastrointestinal Tract Inflammation: Opposing Effects in Crohn’s Disease and Ulcerative Colitis. Front. Immunol. 9:74. doi: 10.3389/fimmu.2018.00074
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.00074/full
348. What is Crohn's disease? A Mayo Clinic expert explains Learn more about Crohn's disease from gastroenterologist William Faubion, M.D., Oct. 29, 2024
https://www.mayoclinic.org/diseases-conditions/crohns-disease/symptoms-causes/syc-20353304
349. Last Reviewed July 2024, Diagnosis of Crohn’s Disease, the National Institute of Diabetes and Digestive and Kidney Diseases
https://www.niddk.nih.gov/health-information/digestive-diseases/crohns-disease/diagnosis
350. Bischoff SC, Escher J, Hébuterne X, Kłęk S, Krznaric Z, Schneider S, Shamir R, Stardelova K, Wierdsma N, Wiskin AE, Forbes A. ESPEN practical guideline: Clinical Nutrition in inflammatory bowel disease. Clin Nutr. 2020 Mar;39(3):632-653. doi: 10.1016/j.clnu.2019.11.002. Epub 2020 Jan 13. PMID: 32029281.
https://www.espen.org/files/ESPEN-Guidelines/ESPEN_practical_guideline_Clinical_Nutrition_in_inflammatory_bowel_disease.pdf
351. October 3, 2014 19 Μαίου Παγκόσμια Ημέρα ΙΦΝΕ Σύλλογος Ατόμων με Νόσο του Crohn και Ελκώδη Κολίτιδα Ελλάδας (HELLESCC)
https://crohnhellas.gr/19-maiou-pagkosmia-imera-ifne-2012/
352. Kumar B, Shah MAA, Kumari R, et al. Depression, Anxiety, and Stress Among Final-year Medical Students. Cureus. 2019 Mar;11(3):e4257. DOI: 10.7759/cureus.4257. PMID: 31139516; PMCID: PMC6519980.
https://europepmc.org/article/MED/31139516
353. Shamsuddin K, Fadzil F, Ismail WS, Shah SA, Omar K, Muhammad NA, Jaffar A, Ismail A, Mahadevan R. Correlates of depression, anxiety and stress among Malaysian university students. Asian J Psychiatr. 2013 Aug;6(4):318-23. doi: 10.1016/j.ajp.2013.01.014. Epub 2013 Mar 1. PMID: 23810140.
https://pubmed.ncbi.nlm.nih.gov/23810140/
354. Regehr C, Glancy D, Pitts A. Interventions to reduce stress in university students: a review and meta-analysis. J Affect Disord. 2013 May 15;148(1):1-11. doi: 10.1016/j.jad.2012.11.026. Epub 2012 Dec 13. PMID: 23246209.
https://pubmed.ncbi.nlm.nih.gov/23246209/
355. Lattie EG, Adkins EC, Winquist N, et al. Digital Mental Health Interventions for Depression, Anxiety, and Enhancement of Psychological Well-Being Among College Students: Systematic Review. Journal of Medical Internet Research. 2019 Jul;21(7):e12869. DOI: 10.2196/12869. PMID: 31333198; PMCID: PMC6681642.
https://europepmc.org/article/MED/31333198
356. Liu CH, Stevens C, Wong SHM, Yasui M, Chen JA. The prevalence and predictors of mental health diagnoses and suicide among U.S. college students: Implications for addressing disparities in service use. Depression and Anxiety. 2019 Jan;36(1):8-17. DOI: 10.1002/da.22830. PMID: 30188598; PMCID: PMC6628691.
https://europepmc.org/article/MED/30188598
357. Ebert DD, Franke M, Kählke F, et al. Increasing intentions to use mental health services among university students. Results of a pilot randomized controlled trial within the World Health Organization's World Mental Health International College Student Initiative. International Journal of Methods in Psychiatric Research. 2019 Jun;28(2):e1754. DOI: 10.1002/mpr.1754. PMID: 30456814; PMCID: PMC6877244.
https://europepmc.org/article/MED/30456814
358. González-Valero G, Zurita-Ortega F, Ubago-Jiménez JL, Puertas-Molero P. Use of Meditation and Cognitive Behavioral Therapies for the Treatment of Stress, Depression and Anxiety in Students. A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health. 2019 Nov;16(22):E4394. DOI: 10.3390/ijerph16224394. PMID: 31717682; PMCID: PMC6888319.
https://europepmc.org/article/MED/31717682
359. Davies EB, Morriss R, Glazebrook C. Computer-delivered and web-based interventions to improve depression, anxiety, and psychological well-being of university students: a systematic review and meta-analysis. J Med Internet Res. 2014 May 16;16(5):e130. doi: 10.2196/jmir.3142. PMID: 24836465; PMCID: PMC4051748.
https://pubmed.ncbi.nlm.nih.gov/24836465/
360. Matar Boumosleh J, Jaalouk D. Depression, anxiety, and smartphone addiction in university students- A cross sectional study. PLoS One. 2017 Aug 4;12(8):e0182239. doi: 10.1371/journal.pone.0182239. PMID: 28777828; PMCID: PMC5544206.
https://pubmed.ncbi.nlm.nih.gov/28777828/
361. Latas M, Pantić M, Obradović D. [Analysis of test anxiety in medical students]. Medicinski Pregled. 2010 Nov-Dec;63(11-12):863-866. DOI: 10.2298/mpns1012863l. PMID: 21553469.
http://europepmc.org/article/MED/21553469
362. Dikmen M. Test anxiety in online exams: scale development and validity. Current Psychology (New Brunswick, N.J.). 2022 Dec:1-13. DOI: 10.1007/s12144-022-04072-0. PMID: 36474484; PMCID: PMC9715417.
https://europepmc.org/article/MED/36474484
363. Lewis JE, Poles J, Shaw DP, et al. The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. Journal of Clinical and Translational Research. 2021 Aug;7(4):575-620. PMID: 34541370; PMCID: PMC8445631.
https://europepmc.org/article/MED/34541370
364. Iqbal AM, Jamal SF. Essential Hypertension. [Updated 2023 Jul 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK539859/
365. Essential hypertension, 08 Jan 2025, BMJ Best Practice
https://bestpractice.bmj.com/topics/en-gb/26
366. Chen S. Essential hypertension: perspectives and future directions. J Hypertens. 2012 Jan;30(1):42-5. doi: 10.1097/HJH.0b013e32834ee23c. PMID: 22157586; PMCID: PMC4152852.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4152852/
367. Carthy ER. Autonomic dysfunction in essential hypertension: A systematic review. Ann Med Surg (Lond). 2013 Dec 11;3(1):2-7. doi: 10.1016/j.amsu.2013.11.002. PMID: 25568776; PMCID: PMC4268473.
https://www.sciencedirect.com/science/article/pii/S2049080113000034
368. Verdecchia P, Schillaci G, Borgioni C, Ciucci A, Zampi I, Battistelli M, Gattobigio R, Sacchi N, Porcellati C. Cigarette smoking, ambulatory blood pressure and cardiac hypertrophy in essential hypertension. J Hypertens. 1995 Oct;13(10):1209-15. doi: 10.1097/00004872-199510000-00016. PMID: 8586813.
https://pubmed.ncbi.nlm.nih.gov/8586813/
369. Primary Hypertension (Formerly Known as Essential Hypertension), Last reviewed on 10/26/2021.
https://my.clevelandclinic.org/health/diseases/22024-primary-hypertension-formerly-known-as-essential-hypertension
370. Nouruzi S, Vasheghani Farahani A, Rezaeizadeh H, Ghafouri P, Ghorashi SM, Omidi N. Platelet Aggregation Inhibition: An Evidence-Based Systematic Review on the Role of Herbs for Primary Prevention Based on Randomized Controlled Trials. Iran J Med Sci. 2022 Nov;47(6):505-516. doi: 10.30476/IJMS.2021.91328.2247. PMID: 36380973; PMCID: PMC9652499.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9652499/
371. Wascher TC, Saely CH; den Ausschuss Leitlinien. Thrombozytenaggregationshemmer (Update 2019) [Inhibition of platelet aggregation (Update 2019)]. Wien Klin Wochenschr. 2019 May;131(Suppl 1):139-140. German. doi: 10.1007/s00508-018-1437-6. PMID: 30980156.
https://pubmed.ncbi.nlm.nih.gov/30980156/
372. Roy, S., Paul, K. Nourishing the clot: a comprehensive review of dietary habits and their implications for platelet function. Bull Fac Phys Ther 29, 7 (2024). https://doi.org/10.1186/s43161-023-00173-4
https://bfpt.springeropen.com/articles/10.1186/s43161-023-00173-4
373. Duttaroy, A.K. Functional Foods in Preventing Human Blood Platelet Hyperactivity-Mediated Diseases—An Updated Review. Nutrients 2024, 16, 3717. https://doi.org/10.3390/nu16213717
https://www.mdpi.com/2072-6643/16/21/3717
374. Yoshimoto, H.; Miyazawa, N.; Eguchi, F. Wild and Cultivated Mushrooms Exhibit Anti-Inflammatory Effects Including Inhibition of Platelet Aggregation and Interleukin-8 Expression. Appl. Microbiol. 2025, 5, 36. https://doi.org/10.3390/applmicrobiol5020036
https://www.mdpi.com/2673-8007/5/2/36
375. Purcell LK; Canadian Paediatric Society, Paediatric Sports and Exercise Medicine Section. Sport nutrition for young athletes. Paediatr Child Health. 2013 Apr;18(4):200-5. doi: 10.1093/pch/18.4.200. PMID: 24421690; PMCID: PMC3805623.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3805623/
376. Maughan RJ, Depiesse F, Geyer H; International Association of Athletics Federations. The use of dietary supplements by athletes. J Sports Sci. 2007;25 Suppl 1:S103-13. doi: 10.1080/02640410701607395. Erratum in: J Sports Sci. 2009 Apr;27(6):667. PMID: 18049988.
https://pubmed.ncbi.nlm.nih.gov/18049988/
377. Yuping Zhu, Gang Song, Molecular origin and biological effects of exercise mimetics, Journal of Exercise Science & Fitness, Volume 22, Issue 1, 2024, Pages 73-85, ISSN 1728-869X, https://doi.org/10.1016/j.jesf.2023.12.002.
https://www.sciencedirect.com/science/article/pii/S1728869X23000643
378. Giacomello, E.; Nicoletti, C.; Canato, M.; Toniolo, L. Exercise Mimetics in Aging: Suggestions from a Systematic Review. Nutrients 2025, 17, 969. https://doi.org/10.3390/nu17060969
https://www.mdpi.com/2072-6643/17/6/969
379. Gubert C, Hannan AJ. Exercise mimetics: harnessing the therapeutic effects of physical activity. Nat Rev Drug Discov. 2021 Nov;20(11):862-879. doi: 10.1038/s41573-021-00217-1. Epub 2021 Jun 8. PMID: 34103713.
https://pubmed.ncbi.nlm.nih.gov/34103713/
380. Vedant Samant, Arati Prabhu, Exercise, exerkines and exercise mimetic drugs: Molecular mechanisms and therapeutics, Life Sciences, Volume 359, 2024, 123225, ISSN 0024-3205, https://doi.org/10.1016/j.lfs.2024.123225.
https://www.sciencedirect.com/science/article/abs/pii/S0024320524008154
381. Li, S. and Laher, I. (2017), Exercise Mimetics: Running Without a Road Map. Clin. Pharmacol. Ther., 101: 188-190. https://doi.org/10.1002/cpt.533
https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.533
382. Cento, A.S., Leigheb, M., Caretti, G. et al. Exercise and Exercise Mimetics for the Treatment of Musculoskeletal Disorders. Curr Osteoporos Rep 20, 249–259 (2022). https://doi.org/10.1007/s11914-022-00739-6
https://link.springer.com/article/10.1007/s11914-022-00739-6
383. Fan W, Evans RM. Exercise Mimetics: Impact on Health and Performance. Cell Metab. 2017 Feb 7;25(2):242-247. doi: 10.1016/j.cmet.2016.10.022. Epub 2016 Nov 23. PMID: 27889389; PMCID: PMC5555683.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5555683/
384. Zhao, R. Exercise mimetics: a novel strategy to combat neuroinflammation and Alzheimer’s disease. J Neuroinflammation 21, 40 (2024). https://doi.org/10.1186/s12974-024-03031-9
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-024-03031-9
385. Silver MD. Use of ergogenic aids by athletes. J Am Acad Orthop Surg. 2001 Jan-Feb;9(1):61-70. doi: 10.5435/00124635-200101000-00007. PMID: 11174164.
https://pubmed.ncbi.nlm.nih.gov/11174164/
386. Varillas-Delgado, D. Nutritional Status and Ergogenic Aids in Performance During Exercise and Sports. Nutrients 2025, 17, 1224. https://doi.org/10.3390/nu17071224
https://www.mdpi.com/2072-6643/17/7/1224
387. Thein LA, Thein JM, Landry GL. Ergogenic aids. Phys Ther. 1995 May;75(5):426-39. doi: 10.1093/ptj/75.5.426. PMID: 7732086.
https://pubmed.ncbi.nlm.nih.gov/7732086/
388. Institute of Medicine (US) Committee on Military Nutrition Research; Marriott BM, editor. Food Components to Enhance Performance: An Evaluation of Potential Performance-Enhancing Food Components for Operational Rations. Washington (DC): National Academies Press (US); 1994. 12, Food Components That May Optimize Physical Performance: An Overview.
https://www.ncbi.nlm.nih.gov/books/NBK209034/
389. Ketterly J. Sports Medicine: Ergogenic Aids. FP Essent. 2022 Jul;518:23-28. PMID: 35830325.
https://pubmed.ncbi.nlm.nih.gov/35830325/
390. Maughan RJ. Nutritional ergogenic aids and exercise performance. Nutr Res Rev. 1999 Dec;12(2):255-80. doi: 10.1079/095442299108728956. PMID: 19087454.
https://pubmed.ncbi.nlm.nih.gov/19087454/
391. Wickham KA, Spriet LL. Food for thought: Physiological considerations for nutritional ergogenic efficacy. Scand J Med Sci Sports. 2024; 34:e14307. doi:10.1111/sms.14307
https://onlinelibrary.wiley.com/doi/10.1111/sms.14307
392. Ahrendt DM. Ergogenic aids: counseling the athlete. Am Fam Physician. 2001 Mar 1;63(5):913-22. PMID: 11261867.
https://www.aafp.org/pubs/afp/issues/2001/0301/p913.html
393. Chelladurai, Packianathan. (2008). Athletics IS Education: A Response to Kane, Leo, and Holleran’s (2008) Case Study of University of Minnesota Student-Athletes. Journal of Intercollegiate Sport. 1. 130-138. 10.1123/jis.1.1.130.
https://www.researchgate.net/publication/306054098_Athletics_IS_Education_A_Response_to_Kane_Leo_and_Holleran's_2008_Case_Study_of_University_of_Minnesota_Student-Athletes
394. Forbes SC, Best R and Dominguez R (2024) Editorial: Dietary supplements and ergogenic aids in relation to health and performance. Front. Sports Act. Living 6:1450604. doi: 10.3389/fspor.2024.1450604
https://www.frontiersin.org/journals/sports-and-active-living/articles/10.3389/fspor.2024.1450604/full
395. Dunn J, Grider MH. Physiology, Adenosine Triphosphate. [Updated 2023 Feb 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK553175/
https://www.ncbi.nlm.nih.gov/books/NBK553175/
396. Ralf Jäger, Martin Purpura, John A. Rathmacher, John C. Fuller, Lisa M. Pitchford, Fabricio E. Rossi, Chad M. Kerksick, Health and ergogenic potential of oral adenosine-5′-triphosphate (ATP) supplementation, Journal of Functional Foods, Volume 78, 2021, 104357, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2021.104357.
https://www.sciencedirect.com/science/article/pii/S1756464621000062
397. Morgan A. O'Brien, Derek G. Power, A. James P. Clover, Brian Bird, Declan M. Soden, Patrick F. Forde, Local tumour ablative therapies: Opportunities for maximising immune engagement and activation, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1846, Issue 2, 2014, Pages 510-523, ISSN 0304-419X, https://doi.org/10.1016/j.bbcan.2014.09.005.
https://www.sciencedirect.com/science/article/pii/S0304419X14000870
398. Greiner, J.V.; Glonek, T. Adenosine Triphosphate (ATP) and Protein Aggregation in Age-Related Vision-Threatening Ocular Diseases. Metabolites 2023, 13, 1100. https://doi.org/10.3390/metabo13101100
https://www.mdpi.com/2218-1989/13/10/1100
399. Jensen J, Rustad PI, Kolnes AJ, Lai YC. The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise. Front Physiol. 2011 Dec 30;2:112. doi: 10.3389/fphys.2011.00112. PMID: 22232606; PMCID: PMC3248697.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3248697/
400. Knuiman, P., Hopman, M.T.E. & Mensink, M. Glycogen availability and skeletal muscle adaptations with endurance and resistance exercise. Nutr Metab (Lond) 12, 59 (2015). https://doi.org/10.1186/s12986-015-0055-9
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-015-0055-9
401. Iliana López-Soldado, Joan J. Guinovart, Jordi Duran, Increased liver glycogen levels enhance exercise capacity in mice, Journal of Biological Chemistry, Volume 297, Issue 2, 2021, 100976, ISSN 0021-9258, https://doi.org/10.1016/j.jbc.2021.100976.
https://www.sciencedirect.com/science/article/pii/S002192582100778X
402. Ørtenblad N, Westerblad H, Nielsen J. Muscle glycogen stores and fatigue. J Physiol. 2013 Sep 15;591(18):4405-13. doi: 10.1113/jphysiol.2013.251629. Epub 2013 May 7. PMID: 23652590; PMCID: PMC3784189.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3784189/
403. Yun-tao Ma, CHAPTER 5 - Overtraining Syndrome and the Use of Muscle in Exercise, Editor(s): Yun-tao Ma, Acupuncture for Sports and Trauma Rehabilitation, Churchill Livingstone, 2011, Pages 36-48, ISBN 9781437709278, https://doi.org/10.1016/B978-1-4377-0927-8.00005-1.
https://www.sciencedirect.com/topics/immunology-and-microbiology/muscle-fatigue
404. W.W. Hay, GROWTH AND DEVELOPMENT, PHYSIOLOGICAL ASPECTS, Editor(s): Benjamin Caballero, Encyclopedia of Human Nutrition (Second Edition), Elsevier, 2005, Pages 423-433, ISBN 9780122266942, https://doi.org/10.1016/B0-12-226694-3/00156-3.
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/glycogen-liver-level
405. Glycogen, Last reviewed on 07/13/2022. Cleveland Clinic
https://my.clevelandclinic.org/health/articles/23509-glycogen
406. Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton SB, Brand-Miller J. Acne vulgaris: a disease of Western civilization. Arch Dermatol. 2002 Dec;138(12):1584-90. doi: 10.1001/archderm.138.12.1584. PMID: 12472346.
https://pubmed.ncbi.nlm.nih.gov/12472346/
407. Matsui MS. Update on diet and acne. Cutis. 2019 Jul;104(1):11-13. PMID: 31487341.
https://cdn.mdedge.com/files/s3fs-public/CT104001011.PDF
408. J Am Acad Dermatol. 2016 May;74(5):945-73.e33. doi: 10.1016/j.jaad.2015.12.037. Epub 2016 Feb 17. Guidelines of Care for the Management of Acne Vulgaris Andrea L Zaenglein, Arun L Pathy, Bethanee J Schlosser, Ali Alikhan, Hilary E Baldwin, Diane S Berson, Whitney P Bowe, Emmy M Graber, Julie C Harper, Sewon Kang, Jonette E Keri, James J Leyden, Rachel V Reynolds, Nanette B Silverberg, Linda F Stein Gold, Megha M Tollefson, Jonathan S Weiss, Nancy C Dolan, Andrew A Sagan, Mackenzie Stern, Kevin M Boyer, Reva Bhushan
https://pubmed.ncbi.nlm.nih.gov/26897386
409. Am Fam Physician. 2019 Oct 15;100(8):475-484. Acne Vulgaris: Diagnosis and Treatment Linda K Oge', Alan Broussard, Marilyn D Marshall
https://pubmed.ncbi.nlm.nih.gov/31613567
410. Br J Dermatol. 2015 Jul;172 Suppl 1:3-12. doi: 10.1111/bjd.13462. A Global Perspective on the Epidemiology of Acne J K L Tan, K Bhate
https://pubmed.ncbi.nlm.nih.gov/25597339
411. Eur J Dermatol . 2017 Aug 1;27(4):393-398. doi: 10.1684/ejd.2017.3062. Adult Female Acne Treated With Spironolactone: A Retrospective Data Review of 70 Cases Anne Isvy-Joubert, Jean-Michel Nguyen, Aurélie Gaultier, Mélanie Saint-Jean, Marie Le Moigne, Elodie Boisrobert, Amir Khammari, Brigitte Dreno
https://pubmed.ncbi.nlm.nih.gov/28862134
412. Acta Derm Venereol . 2013 Nov;93(6):644-9. doi: 10.2340/00015555-1677. Acne: Risk Indicator for Increased Body Mass Index and Insulin Resistance Bodo C Melnik 1 , Swen Malte John, Gerd Plewig
https://pubmed.ncbi.nlm.nih.gov/23975508/
https://www.researchgate.net/publication/256102062_Acne_Risk_Indicator_for_Increased_Body_Mass_Index_and_Insulin_Resistance
413.Cochrane Database Syst Rev. 2018 Nov 24;11(11):CD009435. doi: 10.1002/14651858.CD009435.pub2. Oral Isotretinoin for Acne Caroline S Costa , Ediléia Bagatin, Ana Luiza C Martimbianco, Edina Mk da Silva, Marília M Lúcio, Parker Magin, Rachel Riera
https://pubmed.ncbi.nlm.nih.gov/30484286
414. Am J Clin Dermatol. 2017 Jun;18(3):311-321. doi: 10.1007/s40257-017-0255-3. The Role of Photodynamic Therapy in Acne: An Evidence-Based Review Monica Boen, Joshua Brownell, Priyanka Patel, Maria M Tsoukas
https://pubmed.ncbi.nlm.nih.gov/28276005
415. Wiad Lek. 2018;71(1 pt 2):144-147. Indicators of Phagocytosis in Women With Acne During Comprehensive Treatment That Included Immunotherapy and Probiotics Orysya О Syzon, Marianna О Dashko
https://pubmed.ncbi.nlm.nih.gov/29602922
416. Cochrane Database Syst Rev. 2016 Apr 3;4(4):CD011946. doi: 10.1002/14651858.CD011946.pub2. Interventions for Acne Scars Rania Abdel Hay, Khalid Shalaby, Hesham Zaher, Vanessa Hafez, Ching-Chi Chi, Sandra Dimitri, Ashraf F Nabhan, Alison M Layton
https://pubmed.ncbi.nlm.nih.gov/27038134
417. Wu, Y.; Choi, M.-H.; Li, J.; Yang, H.; Shin, H.-J. Mushroom Cosmetics: The Present and Future. Cosmetics 2016, 3, 22. https://doi.org/10.3390/cosmetics3030022
https://www.mdpi.com/2079-9284/3/3/22
418. Εθελοντική Αιμοδοσία για την κάλυψη των αναγκών της Ογκολογικής Μονάδας Παίδων Μαριάννα Β. Βαρδινογιάννη “Ελπίδα”. Ελληνική Εταιρεία Μαστολογίας
https://mastologia.gr/news/167-ethelontiki-aimodosia-gia-tin-kalypsi-ton-anagkon-tis-ogkologikis-monadas-paidon-marianna-v-vardinogianni-elpida
419. Salonen JT, Tuomainen TP, Salonen R, Lakka TA, Nyyssönen K. Donation of blood is associated with reduced risk of myocardial infarction. The Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Epidemiol. 1998 Sep 1;148(5):445-51. doi: 10.1093/oxfordjournals.aje.a009669. PMID: 9737556.
https://pubmed.ncbi.nlm.nih.gov/9737556/
420. Donating blood benefits both recipients and donors, Tayla Holman January 01, 2024, HCA Houston Healthcare
https://www.hcahoustonhealthcare.com/healthy-living/blog/donating-blood-benefits-both-recipients-and-donors
421. Leo R. Zacharski, Bruce K. Chow, Paula S. Howes, Galina Shamayeva, John A. Baron, Ronald L. Dalman, David J. Malenka, C. Keith Ozaki, Philip W. Lavori, Decreased Cancer Risk After Iron Reduction in Patients With Peripheral Arterial Disease: Results From a Randomized Trial, JNCI: Journal of the National Cancer Institute, Volume 100, Issue 14, 16 July 2008, Pages 996–1002, https://doi.org/10.1093/jnci/djn209
https://academic.oup.com/jnci/article-abstract/100/14/996/917996?redirectedFrom=fulltext&login=false
422. Torti SV, Manz DH, Paul BT, Blanchette-Farra N, Torti FM. Iron and Cancer. Annu Rev Nutr. 2018 Aug 21;38:97-125. doi: 10.1146/annurev-nutr-082117-051732. PMID: 30130469; PMCID: PMC8118195.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8118195/
423. Constipation, The Johns Hopkins University
https://www.hopkinsmedicine.org/health/conditions-and-diseases/constipation
424. Complications of Constipation, Stanford Health
https://stanfordhealthcare.org/medical-conditions/primary-care/constipation/complications.html
425. Sundbøll J, Szépligeti SK, Adelborg K, et al Constipation and risk of cardiovascular diseases: a Danish population-based matched cohort study BMJ Open 2020;10:e037080. doi: 10.1136/bmjopen-2020-037080
https://bmjopen.bmj.com/content/10/9/e037080
426. PRESS RELEASE Constipation Associated with Cognitive Aging and Decline Plus, Gut Bacteria Linked to Alzheimer’s Biomarkers, Dementia Risk, Alzheimer’s Association
https://aaic.alz.org/releases_2023/constipation-gut-health-alzheimers-dementia-risk.asp
427. Constipation and faecal impaction, Alzheimer Scotland
https://www.alzscot.org/our-work/dementia-support/information-sheets/constipation-and-faecal-impaction
428. Incontinence and constipation, Alzheimers New Zealand
https://alzheimers.org.nz/get-support/supporting-someone-with-dementia/incontinence-and-constipation/
429. Chen CL, Liang TM, Chen HH, Lee YY, Chuang YC, Chen NC. Constipation and Its Associated Factors among Patients with Dementia. Int J Environ Res Public Health. 2020 Dec 3;17(23):9006. doi: 10.3390/ijerph17239006. PMID: 33287267; PMCID: PMC7730313.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730313/
430. Editorial| Volume 4, ISSUE 11, P811, November 2019, The cost of constipation The Lancet Gastroenterology & Hepatology Published:November, 2019DOI:https://doi.org/10.1016/S2468-1253(19)30297-3
https://www.thelancet.com/journals/langas/article/PIIS2468-1253(19)30297-3/fulltext
431. Bellini, M.; Tonarelli, S.; Barracca, F.; Rettura, F.; Pancetti, A.; Ceccarelli, L.; Ricchiuti, A.; Costa, F.; de Bortoli, N.; Marchi, S.; et al. Chronic Constipation: Is a Nutritional Approach Reasonable? Nutrients 2021, 13, 3386. https://doi.org/10.3390/nu13103386
https://www.mdpi.com/2072-6643/13/10/3386
432. Multiple Sclerosis (MS), The Johns Hopkins University
https://www.hopkinsmedicine.org/health/conditions-and-diseases/multiple-sclerosis-ms
433. Tafti D, Ehsan M, Xixis KL. Multiple Sclerosis. [Updated 2024 Mar 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK499849/
434. Ford H. Clinical presentation and diagnosis of multiple sclerosis. Clin Med (Lond). 2020 Jul;20(4):380-383. doi: 10.7861/clinmed.2020-0292. PMID: 32675142; PMCID: PMC7385797.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7385797/
435. Walton C, King R, Rechtman L, Kaye W, Leray E, Marrie RA, Robertson N, La Rocca N, Uitdehaag B, van der Mei I, Wallin M, Helme A, Angood Napier C, Rijke N, Baneke P. Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition. Mult Scler. 2020 Dec;26(14):1816-1821. doi: 10.1177/1352458520970841. Epub 2020 Nov 11. PMID: 33174475; PMCID: PMC7720355.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7720355/
436. Emilio Portaccio, Melinda Magyari, Eva Kubala Havrdova, Aurelie Ruet, Bruno Brochet, Antonio Scalfari, Massimiliano Di Filippo, Carmen Tur, Xavier Montalban, Maria Pia Amato, Multiple sclerosis: emerging epidemiological trends and redefining the clinical course, The Lancet Regional Health - Europe, Volume 44, 2024, 100977, ISSN 2666-7762, https://doi.org/10.1016/j.lanepe.2024.100977.
https://www.sciencedirect.com/science/article/pii/S2666776224001443
437. Wingerchuk DM. Smoking: effects on multiple sclerosis susceptibility and disease progression. Ther Adv Neurol Disord. 2012 Jan;5(1):13-22. doi: 10.1177/1756285611425694. PMID: 22276073; PMCID: PMC3251901.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3251901/
438. Nishanth K, Tariq E, Nzvere FP, Miqdad M, Cancarevic I. Role of Smoking in the Pathogenesis of Multiple Sclerosis: A Review Article. Cureus. 2020 Aug 5;12(8):e9564. doi: 10.7759/cureus.9564. PMID: 32905534; PMCID: PMC7473606.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7473606/
439. Borros Arneth, Multiple Sclerosis and Smoking, The American Journal of Medicine, Volume 133, Issue 7, 2020, Pages 783-788, ISSN 0002-9343, https://doi.org/10.1016/j.amjmed.2020.03.008.
https://www.sciencedirect.com/science/article/abs/pii/S000293432030228X
440. Manouchehrinia A, Huang J, Hillert J, Alfredsson L, Olsson T, Kockum I and Constantinescu CS (2022) Smoking Attributable Risk in Multiple Sclerosis. Front. Immunol. 13:840158. doi: 10.3389/fimmu.2022.840158
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.840158/full
441. Demyelination: Demyelinating diseases and symptoms Last updated May 27, 2022, by Marisa Wexler, MS Fact-checked by Patricia Silva, PhD
https://multiplesclerosisnewstoday.com/demyelination/
442. Demyelinating disease: What can you do about it?, Eoin P. Flanagan, M.B., B.Ch.
https://www.mayoclinic.org/diseases-conditions/multiple-sclerosis/expert-answers/demyelinating-disease/faq-20058521?
443. Demyelinating Disease, Cleveland Clinic, 10/18/2023
https://my.clevelandclinic.org/health/diseases/demyelinating-disease
444. Signs & Symptoms Consistent with Demyelinating Disease, The National Multiple Sclerosis Society,
https://www.nationalmssociety.org/for-professionals/for-healthcare-professionals/diagnosing-ms/demyelinating-disease
445. Shields DC, Schaecher KE, Saido TC, Banik NL. A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11486-91. doi: 10.1073/pnas.96.20.11486. PMID: 10500203; PMCID: PMC18060.
https://www.pnas.org/doi/full/10.1073/pnas.96.20.11486
446. Aditya G. Shivane, Arundhati Chakrabarty, Multiple sclerosis and demyelination, Current Diagnostic Pathology, Volume 13, Issue 3, 2007, Pages 193-202, ISSN 0968-6053, https://doi.org/10.1016/j.cdip.2007.04.003.
447. Lubetzki C, Stankoff B. Demyelination in multiple sclerosis. Handb Clin Neurol. 2014;122:89-99. doi: 10.1016/B978-0-444-52001-2.00004-2. PMID: 24507514; PMCID: PMC7152443.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152443/
448. Zhao X, Jacob C. Mechanisms of Demyelination and Remyelination Strategies for Multiple Sclerosis. Int J Mol Sci. 2023 Mar 28;24(7):6373. doi: 10.3390/ijms24076373. PMID: 37047344; PMCID: PMC10093908.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093908/
449. Lucchinetti CF, Popescu BF, Bunyan RF, Moll NM, Roemer SF, Lassmann H, Brück W, Parisi JE, Scheithauer BW, Giannini C, Weigand SD, Mandrekar J, Ransohoff RM. Inflammatory cortical demyelination in early multiple sclerosis. N Engl J Med. 2011 Dec 8;365(23):2188-97. doi: 10.1056/NEJMoa1100648. PMID: 22150037; PMCID: PMC3282172.
https://www.nejm.org/doi/full/10.1056/NEJMoa1100648
450. What Are Demyelinating Diseases? Medically Reviewed by Christopher Melinosky, MD on September 06, 2022 Written by Rachel Reiff Ellis, WebMD LLC
https://www.webmd.com/multiple-sclerosis/what-are-demyelinating-disorders
451. Demyelination: What Is It and Why Does It Happen?, Medically reviewed by Heidi Moawad, M.D. — Written by The Healthline Editorial Team on March 27, 2014
https://www.healthline.com/health/multiple-sclerosis/demyelination
452. What to Know About Demyelination, the Driving Force of Multiple Sclerosis, By Sara Gaynes LevyMedically reviewed by Mia Tova Minen, MD, MPH March 7, 2022
https://www.self.com/story/demyelination-and-ms
453. Haider L, Simeonidou C, Steinberger G, et al Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron Journal of Neurology, Neurosurgery & Psychiatry 2014;85:1386-1395.
https://jnnp.bmj.com/content/85/12/1386
454. hematocrit, National Cancer Institute at the National Institutes of Health
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/hematocrit
455. Mondal H, Zubair M. Hematocrit. [Updated 2024 Oct 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK542276/
456. Billett HH. Hemoglobin and Hematocrit. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Boston: Butterworths; 1990. Chapter 151.
https://www.ncbi.nlm.nih.gov/books/NBK259/
457. Turner J, Parsi M, Badireddy M. Anemia. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK499994/
458. F.G. Huffman, S. Nath, Z.C. Shah, ANEMIA (ANAEMIA) | Other Nutritional Causes, Editor(s): Benjamin Caballero, Encyclopedia of Food Sciences and Nutrition (Second Edition), Academic Press, 2003, Pages 226-232, ISBN 9780122270550, https://doi.org/10.1016/B0-12-227055-X/00043-2.
https://www.sciencedirect.com/topics/veterinary-science-and-veterinary-medicine/nutritional-anemia
459. Killeen RB, Kaur A, Afzal M. Acute Anemia. [Updated 2025 Feb 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537232/
460. Stevens GA, Paciorek CJ, Flores-Urrutia MC, Borghi E, Namaste S, Wirth JP, Suchdev PS, Ezzati M, Rohner F, Flaxman SR, Rogers LM. National, regional, and global estimates of anaemia by severity in women and children for 2000-19: a pooled analysis of population-representative data. Lancet Glob Health. 2022 May;10(5):e627-e639. doi: 10.1016/S2214-109X(22)00084-5. PMID: 35427520; PMCID: PMC9023869.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9023869/
461. Malenica M, Prnjavorac B, Bego T, Dujic T, Semiz S, Skrbo S, Gusic A, Hadzic A, Causevic A. Effect of Cigarette Smoking on Haematological Parameters in Healthy Population. Med Arch. 2017 Apr;71(2):132-136. doi: 10.5455/medarh.2017.71.132-136. PMID: 28790546; PMCID: PMC5511531.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5511531/
462. Vitak T, Yurkiv B, Wasser S, Nevo E, Sybirna N. Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus. World J Diabetes. 2017 May 15;8(5):187-201. doi: 10.4239/wjd.v8.i5.187. PMID: 28572880; PMCID: PMC5437617.
https://pubmed.ncbi.nlm.nih.gov/28572880/
463. Teja KS, Suruchi, Rai U, Kumar M, Mohanty O, Roy J, Meshram S. Mushrooms: A Potential Option in the Management of Deficiency and Diseases in Humans. J Pure Appl Microbiol. 2023;17(2):749-760. doi: 10.22207/JPAM.17.2.55
https://microbiologyjournal.org/mushrooms-a-potential-option-in-the-management-of-deficiency-and-diseases-in-humans/
464. Shukla A, Rasquin LI, Anastasopoulou C. Polycystic Ovarian Syndrome. [Updated 2025 May 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459251/
465. Bohsas, H., Alibrahim, H., Swed, S., Abouainain, Y., Aljabali, A., Kazan, L., … Khandaker, M. U. (2024). Prevalence and knowledge of polycystic ovary syndrome (PCOS) and health-related practices among women of Syria: a cross-sectional study. Journal of Psychosomatic Obstetrics & Gynecology, 45(1). https://doi.org/10.1080/0167482X.2024.2318194
https://www.tandfonline.com/doi/full/10.1080/0167482X.2024.2318194#abstract
466. Deswal R, Narwal V, Dang A, Pundir CS. The Prevalence of Polycystic Ovary Syndrome: A Brief Systematic Review. J Hum Reprod Sci. 2020 Oct-Dec;13(4):261-271. doi: 10.4103/jhrs.JHRS_95_18. Epub 2020 Dec 28. PMID: 33627974; PMCID: PMC7879843.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7879843/
467. Singh S, Pal N, Shubham S, Sarma DK, Verma V, Marotta F, Kumar M. Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics. J Clin Med. 2023 Feb 11;12(4):1454. doi: 10.3390/jcm12041454. PMID: 36835989; PMCID: PMC9964744.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9964744/
468. Johnson JE, Daley D, Tarta C, Stanciu PI. Risk of endometrial cancer in patients with polycystic ovarian syndrome: A meta‑analysis. Oncol Lett. 2023 Mar 8;25(4):168. doi: 10.3892/ol.2023.13754. PMID: 36960190; PMCID: PMC10028221.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10028221/
469. Liao WT, Huang JY, Lee MT, Yang YC, Wu CC. Higher risk of type 2 diabetes in young women with polycystic ovary syndrome: A 10-year retrospective cohort study. World J Diabetes. 2022 Mar 15;13(3):240-250. doi: 10.4239/wjd.v13.i3.240. PMID: 35432752; PMCID: PMC8984565.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8984565/
470. Yasmin A, Roychoudhury S, Paul Choudhury A, Ahmed ABF, Dutta S, Mottola F, Verma V, Kalita JC, Kumar D, Sengupta P, Kolesarova A. Polycystic Ovary Syndrome: An Updated Overview Foregrounding Impacts of Ethnicities and Geographic Variations. Life (Basel). 2022 Nov 25;12(12):1974. doi: 10.3390/life12121974. PMID: 36556340; PMCID: PMC9785838.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9785838/
471. Cupisti S, Häberle L, Dittrich R, Oppelt PG, Reissmann C, Kronawitter D, Beckmann MW, Mueller A. Smoking is associated with increased free testosterone and fasting insulin levels in women with polycystic ovary syndrome, resulting in aggravated insulin resistance. Fertil Steril. 2010 Jul;94(2):673-7. doi: 0.1016/j.fertnstert.2009.03.062. Epub 2009 Apr 25. PMID: 19394003.
https://pubmed.ncbi.nlm.nih.gov/19394003/
472. Yang, Y., Zhang, H., Huang, BY. et al. Relationship between smoking, excessive androgen and negative emotions in women with polycystic ovary syndrome (PCOS). J Ovarian Res 17, 211 (2024). https://doi.org/10.1186/s13048-024-01541-x
https://ovarianresearch.biomedcentral.com/articles/10.1186/s13048-024-01541-x
473. Dason ES, Koshkina O, Chan C, Sobel M. Diagnosis and management of polycystic ovarian syndrome. CMAJ. 2024 Jan 28;196(3):E85-E94. doi: 10.1503/cmaj.231251. Erratum in: CMAJ. 2024 Mar 3;196(8):E269. doi: 10.1503/cmaj.240216. Erratum in: CMAJ. 2024 Mar 17;196(10):E351. doi: 10.1503/cmaj.240303. PMID: 38286488; PMCID: PMC10833093.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10833093/
474. Nikokavoura EA, Johnston KL, Broom J, Wrieden WL, Rolland C. Weight loss for women with and without polycystic ovary syndrome following a very low-calorie diet in a community-based setting with trained facilitators for 12 weeks. Diabetes Metab Syndr Obes. 2015 Oct 14;8:495-503. doi: 10.2147/DMSO.S85134. PMID: 26508882; PMCID: PMC4610794.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4610794/
475. Szczuko M, Kikut J, Szczuko U, Szydłowska I, Nawrocka-Rutkowska J, Ziętek M, Verbanac D, Saso L. Nutrition Strategy and Life Style in Polycystic Ovary Syndrome-Narrative Review. Nutrients. 2021 Jul 18;13(7):2452. doi: 10.3390/nu13072452. PMID: 34371961; PMCID: PMC8308732.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8308732/
476. What is Long COVID and how is it treated, 9 May 2025, National Centre for Infectious Diseases
https://www.ncid.sg/News-Events/News/Pages/What-is-Long-COVID-and-how-is-it-treated.aspx
477. Alwan NA, Johnson L. Defining long COVID: Going back to the start. Med. 2021 May 14;2(5):501-504. doi: 10.1016/j.medj.2021.03.003. Epub 2021 Mar 25. PMID: 33786465; PMCID: PMC7992371.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7992371/
478. Al-Oraibi A, Woolf K, Naidu J, Nellums LB, Pan D, Sze S, Tarrant C, Martin CA, Gogoi M, Nazareth J, Divall P, Dempsey B, Lamb D, Pareek M. Global prevalence of long COVID and its most common symptoms among healthcare workers: a systematic review and meta-analysis. BMJ Public Health. 2025 Apr 17;3(1):e000269. doi: 10.1136/bmjph-2023-000269. PMID: 40260126; PMCID: PMC12010341.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12010341/
479. Global Prevalence of Long COVID, its Subtypes and Risk factors: An Updated Systematic Review and Meta-Analysis Yiren Hou, Tian Gu, Zhouchi Ni, Xu Shi, Megan L. Ranney, Bhramar Mukherjee medRxiv 2025.01.01.24319384; doi: https://doi.org/10.1101/2025.01.01.24319384
https://www.medrxiv.org/content/10.1101/2025.01.01.24319384v1.full
480. Lucas Etienne Hermans, Sean Wasserman, Lizhen Xu, John Eikelboom - Long COVID prevalence and risk factors in adults residing in middle- and high-income countries: secondary analysis of the multinational Anti-Coronavirus Therapies (ACT) trials: BMJ Global Health 2025;10:e017126.
https://gh.bmj.com/content/10/4/e017126
481. Hastie, C.E., Lowe, D.J., McAuley, A. et al. True prevalence of long-COVID in a nationwide, population cohort study. Nat Commun 14, 7892 (2023). https://doi.org/10.1038/s41467-023-43661-w
https://www.nature.com/articles/s41467-023-43661-w
482. Trofor AC, Robu Popa D, Melinte OE, Trofor L, Vicol C, Grosu-Creangă IA, Crișan Dabija RA, Cernomaz AT. Looking at the Data on Smoking and Post-COVID-19 Syndrome-A Literature Review. J Pers Med. 2024 Jan 16;14(1):97. doi: 10.3390/jpm14010097. PMID: 38248798; PMCID: PMC10821354.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10821354/
483. de Granda-Orive JI, Solano-Reina S, Jiménez-Ruiz CA. Are Smoking and Vaping Risk Factors of Developing Long and Persistent Post-COVID-19? Open Respir Arch. 2022 Jul 29;4(4):100195. doi: 10.1016/j.opresp.2022.100195. PMID: 37496961; PMCID: PMC9335855.
https://www.elsevier.es/en-revista-open-respiratory-archives-11-avance-resumen-are-smoking-vaping-risk-factors-S2659663622000418
484. Long-term effects of COVID-19 (long COVID), NHS UK, 21 March 2023
https://www.nhs.uk/conditions/covid-19/long-term-effects-of-covid-19-long-covid/
485. Seo JW, Kim SE, Kim Y, Kim EJ, Kim T, Kim T, Lee SH, Lee E, Lee J, Seo YB, Jeong YH, Jung YH, Choi YJ, Song JY. Updated Clinical Practice Guidelines for the Diagnosis and Management of Long COVID. Infect Chemother. 2024 Mar;56(1):122-157. doi: 10.3947/ic.2024.0024. Epub 2024 Mar 13. PMID: 38527781; PMCID: PMC10990882.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10990882/
486. Long Covid and diet, British Dietetic Association
https://www.bda.uk.com/resource/long-covid-and-diet.html
487. Guerra G, Lucariello A, Komici K. Editorial: Long COVID: nutrition and lifestyle changes. Front Nutr. 2024 Feb 21;11:1375449. doi: 10.3389/fnut.2024.1375449. PMID: 38450231; PMCID: PMC10915234.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10915234/
488. Booi, Han-Ni & Lee, mei k & Fung, Shin & Ng, Szuting & Tan, Chon-Seng & Lim, Kuan-Hon & Roberts, Richard & Ting, Kang. (2022). Medicinal Mushrooms and Their Use to Strengthen Respiratory Health During and Post-COVID-19 Pandemic. International Journal of Medicinal Mushrooms. 24. 10.1615/IntJMedMushrooms.2022045068.
https://www.researchgate.net/publication/362027865_Medicinal_Mushrooms_and_Their_Use_to_Strengthen_Respiratory_Health_During_and_Post-COVID-19_Pandemic
489. Slomski A. Trials Test Mushrooms and Herbs as Anti–COVID-19 Agents. JAMA. 2021;326(20):1997–1999. doi:10.1001/jama.2021.19388
https://jamanetwork.com/journals/jama/fullarticle/2786023
490. Phillips JM, Ooi SL, Pak SC. Health-Promoting Properties of Medicinal Mushrooms and Their Bioactive Compounds for the COVID-19 Era-An Appraisal: Do the Pro-Health Claims Measure Up? Molecules. 2022 Apr 1;27(7):2302. doi: 10.3390/molecules27072302. PMID: 35408701; PMCID: PMC9000601.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9000601/
491. Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan, Xuefei Yang, A concise review of mushrooms antiviral and immunomodulatory properties that may combat against COVID-19, Food Chemistry Advances, Volume 1, 2022, 100023, ISSN 2772-753X, https://doi.org/10.1016/j.focha.2022.100023.
https://www.sciencedirect.com/science/article/pii/S2772753X22000120
492. Hetland G, Johnson E, Bernardshaw SV, Grinde B. Can medicinal mushrooms have prophylactic or therapeutic effect against COVID-19 and its pneumonic superinfection and complicating inflammation? Scand J Immunol. 2021 Jan;93(1):e12937. doi: 10.1111/sji.12937. Epub 2020 Jul 29. PMID: 32657436; PMCID: PMC7404338.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7404338/
493. Chapter Medicinal Mushrooms as Nutritional Management for Post COVID-19 Syndromes ByNehal M. El-Deeb, Hesham Ali El Enshasy, Aya M. Fouad, Ahmed M. Kenawy Book Bioprospects of Macrofungi Edition 1st Edition First Published 2023
https://www.taylorfrancis.com/chapters/edit/10.1201/9781003343806-17/medicinal-mushrooms-nutritional-management-post-covid-19-syndromes-nehal-el-deeb-hesham-ali-el-enshasy-aya-fouad-ahmed-kenawy
494. Thiebaud, Robert. (2012). Exercise-Induced Muscle Damage: Is it detrimental or beneficial?. Journal of Trainology. 1. 36-44. 10.17338/trainology.1.2_36.
https://www.jstage.jst.go.jp/article/trainology/1/2/1_36/_article
495. Owens DJ, Twist C, Cobley JN, Howatson G, Close GL. Exercise-induced muscle damage: What is it, what causes it and what are the nutritional solutions? Eur J Sport Sci. 2019 Feb;19(1):71-85. doi: 10.1080/17461391.2018.1505957. Epub 2018 Aug 15. PMID: 30110239.
https://pubmed.ncbi.nlm.nih.gov/30110239/
496. Howatson G, van Someren KA. The prevention and treatment of exercise-induced muscle damage. Sports Med. 2008;38(6):483-503. doi: 10.2165/00007256-200838060-00004. PMID: 18489195.
https://pubmed.ncbi.nlm.nih.gov/18489195/
497. Harty, P.S., Cottet, M.L., Malloy, J.K. et al. Nutritional and Supplementation Strategies to Prevent and Attenuate Exercise-Induced Muscle Damage: a Brief Review. Sports Med - Open 5, 1 (2019). https://doi.org/10.1186/s40798-018-0176-6
https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-018-0176-6.
498. Leite, C.D.F.C.; Zovico, P.V.C.; Rica, R.L.; Barros, B.M.; Machado, A.F.; Evangelista, A.L.; Leite, R.D.; Barauna, V.G.; Maia, A.F.; Bocalini, D.S. Exercise-Induced Muscle Damage after a High-Intensity Interval Exercise Session: Systematic Review. Int. J. Environ. Res. Public Health 2023, 20, 7082. https://doi.org/10.3390/ijerph20227082
https://www.mdpi.com/1660-4601/20/22/7082
499. Sunbol, Khalid & Althiyabi, Fahad & Alshuria, Abdulaziz & Alajwad, Mahdi & Mahlawi, Amoudi & Alsayed, Budur & Alsarhan, Mustafa & Alshehri, Rahaf & Alsahli, Abdulaziz & Alhazmi, Khalid & Esmae, Emtenan. (2022). Etiology, risk factors and complications of exercise induced muscle injury. International Journal Of Community Medicine And Public Health. 10. 10.18203/2394-6040.ijcmph20223319.
https://www.researchgate.net/publication/366387424_Etiology_risk_factors_and_complications_of_exercise_induced_muscle_injury
500. Price TB, Krishnan-Sarin S, Rothman DL. Smoking impairs muscle recovery from exercise. Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E116-22. doi: 10.1152/ajpendo.00543.2002. Epub 2003 Mar 11. PMID: 12637259.
https://pubmed.ncbi.nlm.nih.gov/12637259/
501. İpekoğlu, Gökhan & Taskin, Halil & Şenel, Ömer. (2019). Examination of Exercise-Induced Skeletal and Cardiac Muscle Damage in Terms of Smoking. Montenegrin Journal of Sports Science & Medicine. 8. 10.26773/mjssm.190901.
https://www.researchgate.net/publication/332111862_Examination_of_Exercise-Induced_Skeletal_and_Cardiac_Muscle_Damage_in_Terms_of_Smoking
502. Xu, F.; Zeng, J.; Liu, X.; Lai, J.; Xu, J. Exercise-Induced Muscle Damage and Protein Intake: A Bibliometric and Visual Analysis. Nutrients 2022, 14, 4288. https://doi.org/10.3390/nu14204288
https://www.mdpi.com/2072-6643/14/20/4288
503. Glik A, Douvdevani A. T lymphocytes: the "cellular" arm of acquired immunity in the peritoneum. Perit Dial Int. 2006 Jul-Aug;26(4):438-48. PMID: 16881338.
https://pubmed.ncbi.nlm.nih.gov/16881338/
504. Sun, L., Su, Y., Jiao, A. et al. T cells in health and disease. Sig Transduct Target Ther 8, 235 (2023). https://doi.org/10.1038/s41392-023-01471-y
https://www.nature.com/articles/s41392-023-01471-y
505. Klimpel GR. Immune Defenses. In: Baron S, editor. Medical Microbiology. 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Chapter 50.
https://www.ncbi.nlm.nih.gov/books/NBK8423/
506. Anisha Singha Deo, Shrijana, Sruthika S.U, Shreya Karun, Kashish Bisaria, Koustav Sarkar, Participation of T cells in generating immune protection against cancers, Pathology - Research and Practice, Volume 262, 2024, 155534, ISSN 0344-0338, https://doi.org/10.1016/j.prp.2024.155534.
https://www.sciencedirect.com/science/article/abs/pii/S034403382400445X
507. Chen C, Liu X, Chang CY, Wang HY, Wang RF. The Interplay between T Cells and Cancer: The Basis of Immunotherapy. Genes (Basel). 2023 Apr 28;14(5):1008. doi: 10.3390/genes14051008. PMID: 37239368; PMCID: PMC10218245.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10218245/
508. Ruiz-Argüelles A. T lymphocytes in autoimmunity. In: Anaya JM, Shoenfeld Y, Rojas-Villarraga A, et al., editors. Autoimmunity: From Bench to Bedside [Internet]. Bogota (Colombia): El Rosario University Press; 2013 Jul 18. Chapter 7.
https://www.ncbi.nlm.nih.gov/books/NBK459477/
509. Janeway CA Jr, Travers P, Walport M, et al. Immunobiology: The Immune System in Health and Disease. 5th edition. New York: Garland Science; 2001. Generation of lymphocytes in bone marrow and thymus.
https://www.ncbi.nlm.nih.gov/books/NBK27123/
510. Kono M, Takagi Y, Kawauchi S, Wada A, Morikawa T, Funakoshi K. Non-activated T and B lymphocytes become morphologically distinguishable after detergent treatment. Cytometry A. 2013 Apr;83(4):396-402. doi: 10.1002/cyto.a.22262. Epub 2013 Feb 11. PMID: 23401265.
https://pubmed.ncbi.nlm.nih.gov/23401265/
511. Hernandez CP, Morrow K, Velasco C, Wyczechowska DD, Naura AS, Rodriguez PC. Effects of cigarette smoke extract on primary activated T cells. Cell Immunol. 2013 Mar;282(1):38-43. doi: 10.1016/j.cellimm.2013.04.005. Epub 2013 Apr 22. PMID: 23665673; PMCID: PMC3676722.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3676722/
512. Saint-André, V., Charbit, B., Biton, A. et al. Smoking changes adaptive immunity with persistent effects. Nature 626, 827–835 (2024). https://doi.org/10.1038/s41586-023-06968-8
https://www.nature.com/articles/s41586-023-06968-8
513. Collins N. Dietary Regulation of Memory T Cells. Int J Mol Sci. 2020 Jun 19;21(12):4363. doi: 10.3390/ijms21124363. PMID: 32575427; PMCID: PMC7352243.
https://pubmed.ncbi.nlm.nih.gov/32575427/
514. Cohen S, Danzaki K, MacIver NJ. Nutritional effects on T-cell immunometabolism. Eur J Immunol. 2017 Feb;47(2):225-235. doi: 10.1002/eji.201646423. Epub 2017 Jan 24. PMID: 28054344; PMCID: PMC5342627.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5342627/
515. Guggenheim AG, Wright KM, Zwickey HL. Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology. Integr Med (Encinitas). 2014 Feb;13(1):32-44. PMID: 26770080; PMCID: PMC4684115.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4684115/
516. Hetland, Geir, Johnson, Egil, Lyberg, Torstein, Kvalheim, Gunnar, The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation, Advances in Pharmacological and Pharmaceutical Sciences, 2011, 157015, 10 pages, 2011. https://doi.org/10.1155/2011/157015
https://onlinelibrary.wiley.com/doi/10.1155/2011/157015
517. Pahwa R, Goyal A, Jialal I. Chronic Inflammation. [Updated 2023 Aug 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK493173/
518. Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2017 Dec 14;9(6):7204-7218. doi: 10.18632/oncotarget.23208. PMID: 29467962; PMCID: PMC5805548.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5805548/
519. Sarah Kraus, Nadir Arber, Inflammation and colorectal cancer, Current Opinion in Pharmacology, Volume 9, Issue 4, 2009, Pages 405-410, ISSN 1471-4892, https://doi.org/10.1016/j.coph.2009.06.006.
https://www.sciencedirect.com/science/article/abs/pii/S1471489209000812
520. Maddipati KR (2024) Distinct etiology of chronic inflammation – implications on degenerative diseases and cancer therapy. Front. Immunol. 15:1460302. doi: 10.3389/fimmu.2024.1460302
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1460302/full
521. Cacciatore, S.; Andaloro, S.; Bernardi, M.; Oterino Manzanas, A.; Spadafora, L.; Figliozzi, S.; Asher, E.; Rana, J.S.; Ecarnot, F.; Gragnano, F.; et al. Chronic Inflammatory Diseases and Cardiovascular Risk: Current Insights and Future Strategies for Optimal Management. Int. J. Mol. Sci. 2025, 26, 3071. https://doi.org/10.3390/ijms26073071
https://www.mdpi.com/1422-0067/26/7/3071
522. Placha D, Jampilek J. Chronic Inflammatory Diseases, Anti-Inflammatory Agents and Their Delivery Nanosystems. Pharmaceutics. 2021 Jan 6;13(1):64. doi: 10.3390/pharmaceutics13010064. PMID: 33419176; PMCID: PMC7825503.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7825503/
523. Alejandra P. Garza, Lorena Morton, Éva Pállinger, Edit I. Buzás, Stefanie Schreiber, Björn H. Schott, Ildiko Rita Dunay, Initial and ongoing tobacco smoking elicits vascular damage and distinct inflammatory response linked to neurodegeneration, Brain, Behavior, & Immunity - Health, Volume 28, 2023, 100597, ISSN 2666-3546, https://doi.org/10.1016/j.bbih.2023.100597.
https://www.sciencedirect.com/science/article/pii/S266635462300011X
524. Lee J, Taneja V, Vassallo R. Cigarette smoking and inflammation: cellular and molecular mechanisms. J Dent Res. 2012 Feb;91(2):142-9. doi: 10.1177/0022034511421200. Epub 2011 Aug 29. PMID: 21876032; PMCID: PMC3261116.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3261116/
525. Yan S, Ma Z, Jiao M, Wang Y, Li A and Ding S (2021) Effects of Smoking on Inflammatory Markers in a Healthy Population as Analyzed via the Gut Microbiota. Front. Cell. Infect. Microbiol. 11:633242. doi: 10.3389/fcimb.2021.633242
https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2021.633242/full
526. Smoking Can Be Hazardous to Your Joints, Linda Rath | April 20, 2023, Arthritis Foundation
https://www.arthritis.org/diseases/more-about/smoking-can-be-hazardous-to-joints
527. Stumpf F, Keller B, Gressies C, Schuetz P. Inflammation and Nutrition: Friend or Foe? Nutrients. 2023 Feb 25;15(5):1159. doi: 10.3390/nu15051159. PMID: 36904164; PMCID: PMC10005147.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10005147/
528. Scheiber A, Mank V. Anti-Inflammatory Diets. [Updated 2023 Oct 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK597377/
529. Elsayed EA, El Enshasy H, Wadaan MA, Aziz R. Mushrooms: a potential natural source of anti-inflammatory compounds for medical applications. Mediators Inflamm. 2014;2014:805841. doi: 10.1155/2014/805841. Epub 2014 Nov 23. PMID: 25505823; PMCID: PMC4258329.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4258329/
530. Du, Bin & Zhu, Fengmei & Xu, Baojun. (2018). An insight into the anti-inflammatory properties of edible and medicinal mushrooms. Journal of Functional Foods. 47. 10.1016/j.jff.2018.06.003.
https://www.researchgate.net/publication/325732957_An_insight_into_the_anti-inflammatory_properties_of_edible_and_medicinal_mushrooms
531. Venturella G, Ferraro V, Cirlincione F, Gargano ML. Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials. Int J Mol Sci. 2021 Jan 10;22(2):634. doi: 10.3390/ijms22020634. PMID: 33435246; PMCID: PMC7826851.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7826851/
532. Xia Y, Wang D, Li J, Chen M, Wang D, Jiang Z, Liu B. Compounds purified from edible fungi fight against chronic inflammation through oxidative stress regulation. Front Pharmacol. 2022 Sep 9;13:974794. doi: 10.3389/fphar.2022.974794. Erratum in: Front Pharmacol. 2023 Jan 05;13:1081523. doi: 10.3389/fphar.2022.1081523. PMID: 36160418; PMCID: PMC9500316.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9500316/
533. Hetland G, Johnson E, Bernardshaw SV, Grinde B. Can medicinal mushrooms have prophylactic or therapeutic effect against COVID-19 and its pneumonic superinfection and complicating inflammation? Scand J Immunol. 2021 Jan;93(1):e12937. doi: 10.1111/sji.12937. Epub 2020 Jul 29. PMID: 32657436; PMCID: PMC7404338.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7404338/
534. Phillips, J.M.; Ooi, S.L.; Pak, S.C. Health-Promoting Properties of Medicinal Mushrooms and Their Bioactive Compounds for the COVID-19 Era—An Appraisal: Do the Pro-Health Claims Measure Up? Molecules 2022, 27, 2302. https://doi.org/10.3390/molecules27072302
https://www.mdpi.com/1420-3049/27/7/2302
535. Lull C, Wichers HJ, Savelkoul HF. Antiinflammatory and immunomodulating properties of fungal metabolites. Mediators Inflamm. 2005 Jun 9;2005(2):63-80. doi: 10.1155/MI.2005.63. PMID: 16030389; PMCID: PMC1160565.
https://pmc.ncbi.nlm.nih.gov/articles/PMC1160565/
536. Emma Camilleri, Renald Blundell, Bikash Baral, Tomasz M. Karpinski, Edlira Aruci, Omar M. Atrooz, A brief overview of the medicinal and nutraceutical importance of Inonotus obliquus (chaga) mushrooms, Heliyon, Volume 10, Issue 15, 2024, e35638, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2024.e35638.
https://www.sciencedirect.com/science/article/pii/S2405844024116696
537. Yin Z, Zhang J, Qin J, Guo L, Guo Q, Kang W, Ma C and Chen L (2024) Anti-inflammatory properties of polysaccharides from edible fungi on health-promotion: a review. Front. Pharmacol. 15:1447677. doi: 10.3389/fphar.2024.1447677
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1447677/full
538. Adekunle Rowaiye, Olobayotan Ifeyomi Wilfred, Olukemi Adejoke Onuh, Doofan Bur, Solomon Oni, Ezinne Janefrances Nwonu, Gordon Ibeanu, Angus Nnamdi Oli, Timipanipiri ThankGod Wood, Modulatory Effects of Mushrooms on the Inflammatory Signaling Pathways and Pro-inflammatory Mediators, Clinical Complementary Medicine and Pharmacology, Volume 2, Issue 4, 2022, 100037, ISSN 2772-3712, https://doi.org/10.1016/j.ccmp.2022.100037.
https://www.sciencedirect.com/science/article/pii/S2772371222000183
539. Leslie SW, Soon-Sutton TL, Khan MAB. Male Infertility. [Updated 2024 Feb 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK562258/
540. Huang, B., Wang, Z., Kong, Y. et al. Global, regional and national burden of male infertility in 204 countries and territories between 1990 and 2019: an analysis of global burden of disease study. BMC Public Health 23, 2195 (2023). https://doi.org/10.1186/s12889-023-16793-3
https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-023-16793-3
541. Shah, Kirati M.; Gamit, Kanan G.; Raval, Manan A.; Vyas, Niraj Y.. Male infertility: A scoping review of prevalence, causes and treatments. Asian Pacific Journal of Reproduction 10(5):p 195-202, October 2021. | DOI: 10.4103/2305-0500.326717
https://journals.lww.com/apjr/fulltext/2021/10050/male_infertility__a_scoping_review_of_prevalence,.1.aspx
542. Agarwal A, Mulgund A, Hamada A, Chyatte MR. A unique view on male infertility around the globe. Reprod Biol Endocrinol. 2015 Apr 26;13:37. doi: 10.1186/s12958-015-0032-1. PMID: 25928197; PMCID: PMC4424520.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4424520/
543. Leslie SW, Soon-Sutton TL, Khan MAB. Male Infertility. 2024 Feb 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 32965929.
https://pubmed.ncbi.nlm.nih.gov/32965929/
544. How common is male infertility, and what are its causes? 11/18/2021, NIH Eunice Kennedy Shriver National Institute of Child Health and Human Development
https://www.nichd.nih.gov/health/topics/menshealth/conditioninfo/infertility
545. Dai JB, Wang ZX, Qiao ZD. The hazardous effects of tobacco smoking on male fertility. Asian J Androl. 2015 Nov-Dec;17(6):954-60. doi: 10.4103/1008-682X.150847. PMID: 25851659; PMCID: PMC4814952.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4814952/
546. Harlev A, Agarwal A, Gunes SO, Shetty A, du Plessis SS. Smoking and Male Infertility: An Evidence-Based Review. World J Mens Health. 2015 Dec;33(3):143-60. doi: 10.5534/wjmh.2015.33.3.143. Epub 2015 Dec 23. PMID: 26770934; PMCID: PMC4709430.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4709430/
547. Liu, Y., Chen, S., Pang, D. et al. Effects of paternal exposure to cigarette smoke on sperm DNA methylation and long-term metabolic syndrome in offspring. Epigenetics & Chromatin 15, 3 (2022). https://doi.org/10.1186/s13072-022-00437-8
https://epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-022-00437-8
548. Kovac JR, Labbate C, Ramasamy R, Tang D, Lipshultz LI. Effects of cigarette smoking on erectile dysfunction. Andrologia. 2015 Dec;47(10):1087-92. doi: 10.1111/and.12393. Epub 2014 Dec 29. PMID: 25557907; PMCID: PMC4485976.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4485976/
549. Skoracka K, Eder P, Łykowska-Szuber L, Dobrowolska A, Krela-Kaźmierczak I. Diet and Nutritional Factors in Male (In)fertility-Underestimated Factors. J Clin Med. 2020 May 9;9(5):1400. doi: 10.3390/jcm9051400. PMID: 32397485; PMCID: PMC7291266.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7291266/
550. Ferramosca A, Zara V. Diet and Male Fertility: The Impact of Nutrients and Antioxidants on Sperm Energetic Metabolism. Int J Mol Sci. 2022 Feb 25;23(5):2542. doi: 10.3390/ijms23052542. PMID: 35269682; PMCID: PMC8910394.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8910394/
551. Pecora, G., Sciarra, F., Gangitano, E. et al. How Food Choices Impact on Male Fertility. Curr Nutr Rep 12, 864–876 (2023). https://doi.org/10.1007/s13668-023-00503-x
https://link.springer.com/article/10.1007/s13668-023-00503-x#citeas
552. Almujaydil, M.S. The Role of Dietary Nutrients in Male Infertility: A Review. Life 2023, 13, 519. https://doi.org/10.3390/life13020519https://www.mdpi.com/2075-1729/13/2/519
553. Finelli R, Mottola F, Agarwal A. Impact of Alcohol Consumption on Male Fertility Potential: A Narrative Review. Int J Environ Res Public Health. 2021 Dec 29;19(1):328. doi: 10.3390/ijerph19010328. PMID: 35010587; PMCID: PMC8751073.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8751073/
554. Vaidya SR, Aeddula NR. Chronic Kidney Disease. [Updated 2024 Jul 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-
https://www.ncbi.nlm.nih.gov/books/NBK535404/
555. Kovesdy CP. Epidemiology of chronic kidney disease: an update 2022. Kidney Int Suppl (2011). 2022 Apr;12(1):7-11. doi: 10.1016/j.kisu.2021.11.003. Epub 2022 Mar 18. PMID: 35529086; PMCID: PMC9073222.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9073222/
556. Lv JC, Zhang LX. Prevalence and Disease Burden of Chronic Kidney Disease. Adv Exp Med Biol. 2019;1165:3-15. doi: 10.1007/978-981-13-8871-2_1. PMID: 31399958.
https://pubmed.ncbi.nlm.nih.gov/31399958/
557. Francis, A., Harhay, M.N., Ong, A.C.M. et al. Chronic kidney disease and the global public health agenda: an international consensus. Nat Rev Nephrol 20, 473–485 (2024). https://doi.org/10.1038/s41581-024-00820-6
https://www.nature.com/articles/s41581-024-00820-6
558. Yacoub R, Habib H, Lahdo A, Al Ali R, Varjabedian L, Atalla G, Kassis Akl N, Aldakheel S, Alahdab S, Albitar S. Association between smoking and chronic kidney disease: a case control study. BMC Public Health. 2010 Nov 25;10:731. doi: 10.1186/1471-2458-10-731. PMID: 21108832; PMCID: PMC3004836.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3004836/
559. Fu YC, Xu ZL, Zhao MY, Xu K. The Association Between Smoking and Renal Function in People Over 20 Years Old. Front Med (Lausanne). 2022 Jun 3;9:870278. doi: 10.3389/fmed.2022.870278. PMID: 35721101; PMCID: PMC9205397.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9205397/
560. Lang, S.M., Schiffl, H. Smoking status, cadmium, and chronic kidney disease. Ren Replace Ther 10, 17 (2024). https://doi.org/10.1186/s41100-024-00533-3
https://rrtjournal.biomedcentral.com/articles/10.1186/s41100-024-00533-3
561. Chen TK, Knicely DH, Grams ME. Chronic Kidney Disease Diagnosis and Management: A Review. JAMA. 2019 Oct 1;322(13):1294-1304. doi: 10.1001/jama.2019.14745. PMID: 31573641; PMCID: PMC7015670.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7015670/
562. Diagnosis - Chronic kidney disease, UK NHS
https://www.nhs.uk/conditions/kidney-disease/diagnosis/
563. Singh AK, Narsipur SS. Cyclosporine: A Commentary on Brand versus Generic Formulation Exchange. J Transplant. 2011;2011:480642. doi: 10.1155/2011/480642. Epub 2011 Nov 17. PMID: 22174986; PMCID: PMC3235899.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3235899/
564. Park H. The emergence of mycophenolate mofetilin dermatology: from its roots in the world of organ transplantation to its versatile role in the dermatology treatment room. J Clin Aesthet Dermatol. 2011 Jan;4(1):18-27. PMID: 21278895; PMCID: PMC3030212.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3030212/
565. Vivier, E., Rebuffet, L., Narni-Mancinelli, E. et al. Natural killer cell therapies. Nature 626, 727–736 (2024). https://doi.org/10.1038/s41586-023-06945-1
https://www.nature.com/articles/s41586-023-06945-1
566. Freud AG, Mundy-Bosse BL, Yu J, Caligiuri MA. The Broad Spectrum of Human Natural Killer Cell Diversity. Immunity. 2017 Nov 21;47(5):820-833. doi: 10.1016/j.immuni.2017.10.008. PMID: 29166586; PMCID: PMC5728700.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5728700/
567. Mace EM. Human natural killer cells: Form, function, and development. J Allergy Clin Immunol. 2023 Feb;151(2):371-385. doi: 10.1016/j.jaci.2022.09.022. Epub 2022 Oct 1. PMID: 36195172; PMCID: PMC9905317.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9905317/
568. Chen, S., Zhu, H. & Jounaidi, Y. Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization. Sig Transduct Target Ther 9, 302 (2024). https://doi.org/10.1038/s41392-024-02005-w
https://www.nature.com/articles/s41392-024-02005-w
569. Zaharescu, I.; Moldovan, A.D.; Tanase, C. Natural Killer (NK) Cells and Their Involvement in Different Types of Cancer—Current Status of Clinical Research. J. Mind Med. Sci. 2017, 4, 31-37. https://doi.org/10.22543/7674.41.P3137
https://www.mdpi.com/2392-7674/4/1/6
570. Lodoen MB, Lanier LL. Natural killer cells as an initial defense against pathogens. Curr Opin Immunol. 2006 Aug;18(4):391-8. doi: 10.1016/j.coi.2006.05.002. Epub 2006 Jun 12. PMID: 16765573; PMCID: PMC7127478.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7127478/
571. Inoue C, Takeshita T, Kondo H, Morimoto K. Cigarette smoking is associated with the reduction of lymphokine-activated killer cell and natural killer cell activities. Environ Health Prev Med. 1996 Apr;1(1):14-9. doi: 10.1007/BF02931167. PMID: 21432415.
https://pubmed.ncbi.nlm.nih.gov/21432415/
572. M. Takeuchi, S. Nagai, A. Nakajima, M. Shinya, C. Tsukano, H. Asada, K. Yoshikawa, M. Yoshimura, T. Izumi; Inhibition of Lung Natural Killer Cell Activity by Smoking: The Role of Alveolar Macrophages. Respiration 1 June 2001; 68 (3): 262–267. https://doi.org/10.1159/000050508
https://karger.com/res/article-abstract/68/3/262/288207/Inhibition-of-Lung-Natural-Killer-Cell-Activity-by?redirectedFrom=fulltext
573. Kanehisa Morimoto, Tatsuya Takeshita, Masanobu Nanno, Shinkan Tokudome, Kunio Nakayama, Modulation of natural killer cell activity by supplementation of fermented milk containing Lactobacillus casei in habitual smokers, Preventive Medicine, Volume 40, Issue 5, 2005, Pages 589-594, ISSN 0091-7435, https://doi.org/10.1016/j.ypmed.2004.07.019.
https://www.sciencedirect.com/science/article/abs/pii/S0091743504004177
574. Ferson, M., Edwards, A., Lind, A., Milton, G.W. and Hersey, P. (1979), Low natural killer-cell activity and immunoglobulin levels associated with smoking in human subjects. Int. J. Cancer, 23: 603-609. https://doi.org/10.1002/ijc.2910230504
https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.2910230504
575. Inoue, C., Takeshita, T., Kondo, H. et al. Cigarette smoking is associated with the reduction of lymphokine-activated killer cell and natural killer cell activities. Environ Health Prev Med 1, 14–19 (1996). https://doi.org/10.1007/BF02931167
https://link.springer.com/article/10.1007/BF02931167
576. Barone J, Hebert JR, Reddy MM. Dietary fat and natural-killer-cell activity. Am J Clin Nutr. 1989 Oct;50(4):861-7. doi: 10.1093/ajcn/50.4.861. PMID: 2801592.
https://pubmed.ncbi.nlm.nih.gov/2801592/
577. Giovanni Ravaglia, Paola Forti, Fabiola Maioli, Luciana Bastagli, Andrea Facchini, Erminia Mariani, Lucia Savarino, Simonetta Sassi, Domenico Cucinotta, Giorgio Lenaz, Effect of micronutrient status on natural killer cell immune function in healthy free-living subjects aged ≥90 y123, The American Journal of Clinical Nutrition, Volume 71, Issue 2, 2000, Pages 590-598, ISSN 0002-9165, https://doi.org/10.1093/ajcn/71.2.590.
https://www.sciencedirect.com/science/article/pii/S0002916523070260
578. Kim YS, Sayers TJ, Colburn NH, Milner JA, Young HA. Impact of dietary components on NK and Treg cell function for cancer prevention. Mol Carcinog. 2015 Sep;54(9):669-78. doi: 10.1002/mc.22301. Epub 2015 Apr 1. PMID: 25845339; PMCID: PMC4536099.
https://pubmed.ncbi.nlm.nih.gov/25845339/
579. Manash Pratim Pathak, Kalyani Pathak, Riya Saikia, Urvashee Gogoi, Mohammad Zaki Ahmad, Pompy Patowary, Aparoop Das, Immunomodulatory effect of mushrooms and their bioactive compounds in cancer: A comprehensive review, Biomedicine & Pharmacotherapy, Volume 149, 2022, 112901, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2022.112901.
https://www.sciencedirect.com/science/article/pii/S0753332222002906
580. Chang C-J, Chen Y-YM, Lu C-C, et al. Ganoderma lucidum stimulates NK cell cytotoxicity by inducing NKG2D/NCR activation and secretion of perforin and granulysin. Innate Immunity. 2013;20(3):301-311. doi:10.1177/1753425913491789
https://journals.sagepub.com/doi/full/10.1177/1753425913491789
581. Guggenheim AG, Wright KM, Zwickey HL. Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology. Integr Med (Encinitas). 2014 Feb;13(1):32-44. PMID: 26770080; PMCID: PMC4684115.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4684115/
582. Golden MI, Meyer JJ, Zeppieri M, Patel BC. Dry Eye Syndrome. 2024 Feb 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 29262012.
https://pubmed.ncbi.nlm.nih.gov/29262012/
583. Golden MI, Meyer JJ, Zeppieri M, et al. Dry Eye Syndrome. [Updated 2024 Feb 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470411/
https://www.ncbi.nlm.nih.gov/books/NBK470411/
584. Yamada M, Mizuno Y, Shigeyasu C. Impact of dry eye on work productivity. Clinicoecon Outcomes Res. 2012;4:307-12. doi: 10.2147/CEOR.S36352. Epub 2012 Oct 10. PMID: 23091391; PMCID: PMC3471464.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3471464/
585. Guo OD LW, Akpek E. The negative effects of dry eye disease on quality of life and visual function. Turk J Med Sci. 2020 Nov 3;50(SI-2):1611-1615. doi: 10.3906/sag-2002-143. PMID: 32283910; PMCID: PMC7672346.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7672346/
586. Wróbel-Dudzińska D, Osial N, Stępień PW, Gorecka A, Żarnowski T. Prevalence of Dry Eye Symptoms and Associated Risk Factors among University Students in Poland. Int J Environ Res Public Health. 2023 Jan 11;20(2):1313. doi: 10.3390/ijerph20021313. PMID: 36674068; PMCID: PMC9859544.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9859544/
587. He Q, Chen Z, Xie C, Liu L and Wei R (2022) The Association Between Dry Eye Disease With Depression, Anxiety and Sleep Disturbance During COVID-19. Front. Psychiatry 12:802302. doi: 10.3389/fpsyt.2021.802302
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2021.802302/full
588. Yang, K., Zhang, H., Wang, Y. et al. Evaluating the impact of smoking on the risk of dry eye disease: a two-sample Mendelian randomization study. Sci Rep 14, 32043 (2024). https://doi.org/10.1038/s41598-024-83795-5
https://www.nature.com/articles/s41598-024-83795-5
589. Solberg Y, Rosner M, Belkin M. The association between cigarette smoking and ocular diseases. Surv Ophthalmol. 1998 May-Jun;42(6):535-47. doi: 10.1016/s0039-6257(98)00002-2. PMID: 9635902.
https://pubmed.ncbi.nlm.nih.gov/9635902/
590. Xu L, Zhang W, Zhu XY, Suo T, Fan XQ, Fu Y. Smoking and the risk of dry eye: a Meta-analysis. Int J Ophthalmol. 2016 Oct 18;9(10):1480-1486. doi: 10.18240/ijo.2016.10.19. PMID: 27803868; PMCID: PMC5075666.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5075666/
591. Areesanan A, Wasilewicz A, Nicolay S, Grienke U, Zimmermann-Klemd AM, Rollinger JM and Gründemann C (2025) Evaluation of in vitro pharmacological activities of medicinal mushrooms in the context of dry eye disease. Front. Pharmacol. 16:1557359. doi: 10.3389/fphar.2025.1557359
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1557359/full
592. El Barche, FZ., Benyoussef, AA., El Habib Daho, M. et al. Automated tear film break-up time measurement for dry eye diagnosis using deep learning. Sci Rep 14, 11723 (2024). https://doi.org/10.1038/s41598-024-62636-5
https://www.nature.com/articles/s41598-024-62636-5
593. Cabaniss CD. Creatine Kinase. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Boston: Butterworths; 1990. Chapter 32.
https://www.ncbi.nlm.nih.gov/books/NBK352/https://www.ncbi.nlm.nih.gov/books/NBK352/
594. Brian R. Berridge, John F. Van Vleet, Eugene Herman, Chapter 46 - Cardiac, Vascular, and Skeletal Muscle Systems, Editor(s): Wanda M. Haschek, Colin G. Rousseaux, Matthew A. Wallig, Haschek and Rousseaux's Handbook of Toxicologic Pathology (Third Edition), Academic Press, 2013, Pages 1567-1665, ISBN 9780124157590, https://doi.org/10.1016/B978-0-12-415759-0.00046-7.
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/creatine-kinase
595. Moghadam-Kia S, Oddis CV, Aggarwal R. Approach to asymptomatic creatine kinase elevation. Cleve Clin J Med. 2016 Jan;83(1):37-42. doi: 10.3949/ccjm.83a.14120. PMID: 26760521; PMCID: PMC4871266.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4871266/
596. David S. Younger, Chapter 19 - Childhood muscular dystrophies, Editor(s): David S. Younger, Handbook of Clinical Neurology, Elsevier, Volume 195, 2023, Pages 461-496, ISSN 0072-9752, ISBN 9780323988186, https://doi.org/10.1016/B978-0-323-98818-6.00024-8.
https://www.sciencedirect.com/topics/nursing-and-health-professions/creatine-kinase-blood-level
597. Laurence A. Bindoff, CHAPTER 33 - Muscle disease, Editor(s): William J. Marshall, Marta Lapsley, Andrew P. Day, Ruth M. Ayling, Clinical Biochemistry: Metabolic and Clinical Aspects (Third Edition), Churchill Livingstone, 2014, Pages 646-659, ISBN 9780702051401, https://doi.org/10.1016/B978-0-7020-5140-1.00033-X.
https://www.sciencedirect.com/topics/nursing-and-health-professions/creatine-kinase-mm
598. Al-Naseem A, Sallam A, Choudhury S, Thachil J. Iron deficiency without anaemia: a diagnosis that matters. Clin Med (Lond). 2021 Mar;21(2):107-113. doi: 10.7861/clinmed.2020-0582. PMID: 33762368; PMCID: PMC8002799.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8002799/
599. Dufaux B, Hoederath A, Streitberger I, Hollmann W, Assmann G. Serum ferritin, transferrin, haptoglobin, and iron in middle- and long-distance runners, elite rowers, and professional racing cyclists. Int J Sports Med. 1981 Feb;2(1):43-6. doi: 10.1055/s-2008-1034583. PMID: 7333734.
https://pubmed.ncbi.nlm.nih.gov/7333734/
600. Nachtigall D, Nielsen P, Fischer R, Engelhardt R, Gabbe EE. Iron deficiency in distance runners. A reinvestigation using Fe-labelling and non-invasive liver iron quantification. Int J Sports Med. 1996 Oct;17(7):473-9. doi: 10.1055/s-2007-972881. PMID: 8912060.
https://pubmed.ncbi.nlm.nih.gov/8912060/
601. Dickson DN, Wilkinson RL, Noakes TD. Effects of ultra-marathon training and racing on hematologic parameters and serum ferritin levels in well-trained athletes. Int J Sports Med. 1982 May;3(2):111-7. doi: 10.1055/s-2008-1026073. PMID: 7107103.
https://pubmed.ncbi.nlm.nih.gov/7107103/
602. Stanzione JR, Bell G, Greenwood DA. A systematic nutrition intervention for low iron status in collegiate distance runners. Nutr Health. 2022 May 9:2601060221100337. doi: 10.1177/02601060221100337. Epub ahead of print. PMID: 35532088.
https://pubmed.ncbi.nlm.nih.gov/35532088/
603. Lai T-F, Liao Y, Hsueh M-C, Yen H-Y, Park J-H and Chang JH (2022) Substituting sedentary time with physical activity in youngest-old to oldest-old community-dwelling older adults: Associations with body composition. Front. Public Health 10:837213. doi: 10.3389/fpubh.2022.837213
https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.837213/full
604. Huang Z, Liu Y, Zhou Y. Sedentary Behaviors and Health Outcomes among Young Adults: A Systematic Review of Longitudinal Studies. Healthcare (Basel). 2022 Aug 6;10(8):1480. doi: 10.3390/healthcare10081480. PMID: 36011137; PMCID: PMC9408295.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9408295/
605. Bouamra M, Zouhal H, Ratel S, Makhlouf I, Bezrati I, Chtara M, Behm DG, Granacher U and Chaouachi A (2022) Concurrent Training Promotes Greater Gains on Body Composition and Components of Physical Fitness Than Single-Mode Training (Endurance or Resistance) in Youth With Obesity. Front. Physiol. 13:869063. doi: 10.3389/fphys.2022.869063
https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.869063/full
606. W.Clark Hersey, James E. Graves, Michael L. Pollock, Ronald Gingerich, Rachel B. Shireman, Gregory W. Heath, Francis Spierto, Steve D. McCole, James M. Hagberg, Endurance exercise training improves body composition and plasma insulin responses in 70- to 79-year-old men and women, Metabolism, Volume 43, Issue 7, 1994, Pages 847-854, ISSN 0026-0495, https://doi.org/10.1016/0026-0495(94)90265-8.
https://www.sciencedirect.com/science/article/abs/pii/0026049594902658
607. Júdice PB, Hetherington-Rauth M, Magalhães JP, Correia IR, Sardinha LB. Sedentary behaviours and their relationship with body composition of athletes. Eur J Sport Sci. 2022 Mar;22(3):474-480. doi: 10.1080/17461391.2021.1874060. Epub 2021 Feb 2. PMID: 33416024.
https://pubmed.ncbi.nlm.nih.gov/33416024/
608. SEPTEMBER 28, 2022 High-intensity workouts can help you get fit fast, but preparation is key By Cultivating Health, UC Davis Health
https://health.ucdavis.edu/blog/cultivating-health/high-intensity-workouts-can-help-you-get-fit-fast-but-preparation-is-key/2022/09
609. Verbrugghe J, Agten A, Stevens S, Hansen D, Demoulin C, Eijnde BO, Vandenabeele F, Timmermans A. High Intensity Training to Treat Chronic Nonspecific Low Back Pain: Effectiveness of Various Exercise Modes. J Clin Med. 2020 Jul 27;9(8):2401. doi: 10.3390/jcm9082401. PMID: 32727108; PMCID: PMC7465397.
https://pubmed.ncbi.nlm.nih.gov/32727108/
610. Wolski LA, McKenzie DC, Wenger HA. Altitude training for improvements in sea level performance. Is the scientific evidence of benefit? Sports Med. 1996 Oct;22(4):251-63. doi: 10.2165/00007256-199622040-00004. PMID: 8898458.
https://pubmed.ncbi.nlm.nih.gov/8898458/
611. Saunders PU, Pyne DB, Gore CJ. Endurance training at altitude. High Alt Med Biol. 2009 Summer;10(2):135-48. doi: 10.1089/ham.2008.1092. PMID: 19519223.
https://pubmed.ncbi.nlm.nih.gov/19519223/
612. Wolski LA, McKenzie DC, Wenger HA. Altitude training for improvements in sea level performance. Is the scientific evidence of benefit? Sports Med. 1996 Oct;22(4):251-63. doi: 10.2165/00007256-199622040-00004. PMID: 8898458.
https://pubmed.ncbi.nlm.nih.gov/8898458_2
613. Khodaee M, Grothe HL, Seyfert JH, VanBaak K. Athletes at High Altitude. Sports Health. 2016 Mar-Apr;8(2):126-32. doi: 10.1177/1941738116630948. PMID: 26863894; PMCID: PMC4789936.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4789936/
614. González-Ravé JM, Castillo JA, González-Mohino F and Pyne DB (2023) Periodization of altitude training: A collective case study of high-level swimmers. Front. Physiol. 14:1140077. doi: 10.3389/fphys.2023.1140077
https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1140077/full
615. Baoxia Chen, Zhusheng Wu, Xia Huang, Zhichao Li, Qianjin Wu, Zichao Chen, Effect of altitude training on the aerobic capacity of athletes: A systematic review and meta-analysis, Heliyon, Volume 9, Issue 9, 2023, e20188, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2023.e20188.
https://www.sciencedirect.com/science/article/pii/S2405844023073966
616. Deng, L.; Liu, Y.; Chen, B.; Hou, J.; Liu, A.; Yuan, X. Impact of Altitude Training on Athletes’ Aerobic Capacity: A Systematic Review and Meta-Analysis. Life 2025, 15, 305. https://doi.org/10.3390/life15020305
https://www.mdpi.com/2075-1729/15/2/305
617. Płoszczyca K, Langfort J, Czuba M. The Effects of Altitude Training on Erythropoietic Response and Hematological Variables in Adult Athletes: A Narrative Review. Front Physiol. 2018 Apr 11;9:375. doi: 10.3389/fphys.2018.00375. PMID: 29695978; PMCID: PMC5904371.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5904371/
618. High-Altitude Erythrocytosis: Mechanisms of Adaptive and Maladaptive Responses Francisco C. Villafuerte, Tatum S. Simonson, Daniela Bermudez, and Fabiola León-Velarde Physiology 2022 37:4, 175-186
https://journals.physiology.org/doi/full/10.1152/physiol.00029.2021
619. Man MC, Ganera C, Bărbuleț GD, Krzysztofik M, Panaet AE, Cucui AI, Tohănean DI, Alexe DI. The Modifications of Haemoglobin, Erythropoietin Values and Running Performance While Training at Mountain vs. Hilltop vs. Seaside. Int J Environ Res Public Health. 2021 Sep 8;18(18):9486. doi: 10.3390/ijerph18189486. PMID: 34574408; PMCID: PMC8466982.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8466982/
620. Biggs NC, England BS, Turcotte NJ, Cook MR, Williams AL. Effects of Simulated Altitude on Maximal Oxygen Uptake and Inspiratory Fitness. Int J Exerc Sci. 2017 Jan 1;10(1):127-136. doi: 10.70252/BARK5186. PMID: 28479953; PMCID: PMC5214464.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5214464/
621. Chen B, Wu Z, Huang X, Li Z, Wu Q, Chen Z. Effect of altitude training on the aerobic capacity of athletes: A systematic review and meta-analysis. Heliyon. 2023 Sep 16;9(9):e20188. doi: 10.1016/j.heliyon.2023.e20188. PMID: 37809554; PMCID: PMC10559955.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10559955/
622. Wu T, Ding S, Liu J, et al Smoking, acute mountain sickness and altitude acclimatisation: a cohort study Thorax 2012;67:914-919.
https://thorax.bmj.com/content/67/10/914.abstract
623. Stellingwerff T, Peeling P, Garvican-Lewis LA, Hall R, Koivisto AE, Heikura IA, Burke LM. Nutrition and Altitude: Strategies to Enhance Adaptation, Improve Performance and Maintain Health: A Narrative Review. Sports Med. 2019 Dec;49(Suppl 2):169-184. doi: 10.1007/s40279-019-01159-w. PMID: 31691928; PMCID: PMC6901429.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6901429/
624. Koivisto-Mørk AE, Paur I, Paulsen G, Garthe I, Raastad T, Bastani NE, Blomhoff R and Bøhn SK (2020) Dietary Adjustments to Altitude Training in Elite Endurance Athletes; Impact of a Randomized Clinical Trial With Antioxidant-Rich Foods. Front. Sports Act. Living 2:106. doi: 10.3389/fspor.2020.00106
https://www.frontiersin.org/journals/sports-and-active-living/articles/10.3389/fspor.2020.00106/full
625. Tapia C, Nessel TA, Zito PM. Cyclosporine. [Updated 2023 Aug 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK482450/
626. Takeda A, Uchida K, Haba T, Tominaga Y, Katayama A, Yoshida A, Oikawa T, Morozumi K. Chronic cyclosporin nephropathy: long-term effects of cyclosporin on renal allografts. Clin Transplant. 2001;15 Suppl 5:22-9. doi: 10.1034/j.1399-0012.2001.0150s5022.x. PMID: 11791791.
https://pubmed.ncbi.nlm.nih.gov/11791791/
627. Jun Yu, Xiao Wei, Jinzhang Gao, Chun Wang, Wei Wei, Role of cyclosporin A in the treatment of kidney disease and nephrotoxicity, Toxicology, Volume 492, 2023, 153544, ISSN 0300-483X, https://doi.org/10.1016/j.tox.2023.153544.
https://www.sciencedirect.com/science/article/abs/pii/S0300483X23001300
628. Einollahi B, Teimoori M, A Systematic Review about an Advance in Cyclosporine Monitoring in Kidney Transplant Recipients.Nephro-Urol Mon.2017;9(4):e24989.https://doi.org/10.5812/numonthly.24989.
https://brieflands.com/articles/num-55530
629. Ng TH, Britton GJ, Hill EV, Verhagen J, Burton BR, Wraith DC. Regulation of adaptive immunity; the role of interleukin-10. Front Immunol. 2013 May 31;4:129. doi: 10.3389/fimmu.2013.00129. PMID: 23755052; PMCID: PMC3668291.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3668291/
630. Iyer SS, Cheng G. Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease. Crit Rev Immunol. 2012;32(1):23-63. doi: 10.1615/critrevimmunol.v32.i1.30. PMID: 22428854; PMCID: PMC3410706.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3410706/
631. Kaliyaperumal, Y., Sivadasan, S. & Aiyalu, R. Contrast-Induced Nephropathy: An Overview. Dr. Sulaiman Al Habib Med J 5, 118–127 (2023). https://doi.org/10.1007/s44229-023-00040-3
https://link.springer.com/article/10.1007/s44229-023-00040-3
632. Mohammed NM, Mahfouz A, Achkar K, Rafie IM, Hajar R. Contrast-induced Nephropathy. Heart Views. 2013 Jul;14(3):106-16. doi: 10.4103/1995-705X.125926. PMID: 24696755; PMCID: PMC3969626.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3969626/
633. Modi K, Padala SA, Gupta M. Contrast-Induced Nephropathy. [Updated 2025 Jan 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan
https://www.ncbi.nlm.nih.gov/books/NBK448066/
634. R. Mehran, E. Nikolsky, Contrast-induced nephropathy: Definition, epidemiology, and patients at risk, Kidney International, Volume 69, Supplement 100, 2006, Pages S11-S15, ISSN 0085-2538, https://doi.org/10.1038/sj.ki.5000368.
https://www.sciencedirect.com/science/article/pii/S0085253815513872
635. Tascón, J.; Prieto, M.; Casanova, A.G.; Sanz, F.J.; Hernández Mezquita, M.A.; Barrueco Ferrero, M.; Gomez-Marcos, M.A.; Garcia-Ortiz, L.; Vicente-Vicente, L.; Morales, A.I.; et al. Early Diagnosis of Kidney Damage Associated with Tobacco Use: Preventive Application. J. Pers. Med. 2022, 12, 1032. https://doi.org/10.3390/jpm12071032
https://www.mdpi.com/2075-4426/12/7/1032
636. Charlene (Xiaoying) Deng, MD, PhD, MBA, FACP, FASN Assistant Professor of Medicine, Division of Nephrology, Hypertension and Transplantation, Thomas Jefferson University Hospital, Sidney Kimmel Medical College of Thomas Jefferson University
https://emedicine.medscape.com/article/246751-treatment
637. Ying M, Yang J, Huang Z, Ling Y, Wang B, Huang H, Li Q, Liu J, Liu Y, Chen Z. Association between malnutrition and contrast-associated acute kidney injury in congestive heart failure patients following coronary angiography. Front Nutr. 2022 Nov 17;9:937237. doi: 10.3389/fnut.2022.937237. PMID: 36466405; PMCID: PMC9713008.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9713008/
638. Liang J, Zhang L, Huang Z, He Y, Ling Y, Chen K, Ying M, Lin M, Li G, Liu J, Liu Y, Liang Y, Chen S and Hu Y (2022) Implications of Malnutrition on Contrast-Associated Acute Kidney Injury in Young and Old Patients Undergoing Percutaneous Coronary Intervention: A Multicenter Prospective Cohort. Front. Nutr. 8:795068. doi: 10.3389/fnut.2021.795068
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.795068/full
639. Chen, Liling & Huang, Zhidong & Li, Weiguo & He, Yibo & Liang, Jingjing & Lu, Jin & Yang, Yanfang & Huang, Haozhang & Lin, Yihang & Lin, Rongwen & Lin, Mengfei & Liang, Yan & Hu, Yunzhao & Ye, Jianfeng & Hu, Yuying & Liu, Jin & Liu, Yong & Fang, Yong & Chen, Kaihong & Chen, Shiqun. (2022). Malnutrition and the risk for contrast-induced acute kidney injury in patients with coronary artery disease. International Urology and Nephrology. 54. 10.1007/s11255-021-02915-6.
https://www.researchgate.net/publication/352758623_Malnutrition_and_the_risk_for_contrast-induced_acute_kidney_injury_in_patients_with_coronary_artery_disease
640. Liang J, Zhang L, Huang Z, He Y, Ling Y, Chen K, Ying M, Lin M, Li G, Liu J, Liu Y, Liang Y, Chen S, Hu Y. Implications of Malnutrition on Contrast-Associated Acute Kidney Injury in Young and Old Patients Undergoing Percutaneous Coronary Intervention: A Multicenter Prospective Cohort. Front Nutr. 2022 Feb 8;8:795068. doi: 10.3389/fnut.2021.795068. PMID: 35211494; PMCID: PMC8861456.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8861456/
641. Ruth W. Mwangi, John M. Macharia, Isabel N. Wagara, Raposa L. Bence, The antioxidant potential of different edible and medicinal mushrooms, Biomedicine & Pharmacotherapy, Volume 147, 2022, 112621, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2022.112621.
https://www.sciencedirect.com/science/article/pii/S0753332222000099
642. Karunarathna, S. C., Prasannath, K., Lu, W., & Hapuarachchi, K. K. (2024). Ganoderma: bridging traditional wisdom with modern innovation in medicinal mushroom and dietary supplement industry. New Zealand Journal of Botany, 1–60. https://doi.org/10.1080/0028825X.2024.2410486
https://www.tandfonline.com/doi/abs/10.1080/0028825X.2024.2410486
643. Musa R, Rout P, Qurie A. Lupus Nephritis. [Updated 2025 Jan 16]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK499817/
644. Soo-Kyung Cho, Hyoungyoung Kim, Jung-Yong Han, Yena Jeon, Sun-Young Jung, Eun Jin Jang, Yoon-Kyoung Sung, Risk of end-stage renal disease in patients with early-onset lupus nephritis: A population-based cohort study, Seminars in Arthritis and Rheumatism, Volume 63, 2023, 152308, ISSN 0049-0172, https://doi.org/10.1016/j.semarthrit.2023.152308.
https://www.sciencedirect.com/science/article/abs/pii/S0049017223001506
645. Hoover PJ, Costenbader KH. Insights into the epidemiology and management of lupus nephritis from the US rheumatologist's perspective. Kidney Int. 2016 Sep;90(3):487-92. doi: 10.1016/j.kint.2016.03.042. Epub 2016 Jun 22. PMID: 27344205; PMCID: PMC5679458.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5679458/
646. A smoking gun for renal disease in patients with SLE?. Nat Rev Rheumatol 11, 562 (2015). https://doi.org/10.1038/nrrheum.2015.122
https://www.nature.com/articles/nrrheum.2015.122
647. Xu D, You X, Wang Z, Zeng Q, Xu J, Jiang L, Gong L, Wu F, Gu J, Tao Y, Chen J, Zhao J, Li M, Zhao Y, Zeng X; CSTAR co-authors. Chinese Systemic Lupus Erythematosus Treatment and Research Group Registry VI: Effect of Cigarette Smoking on the Clinical Phenotype of Chinese Patients with Systemic Lupus Erythematosus. PLoS One. 2015 Aug 17;10(8):e0134451. doi: 10.1371/journal.pone.0134451. PMID: 26280671; PMCID: PMC4539270.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4539270/
648. Islam MA, Khandker SS, Kotyla PJ, Hassan R. Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review. Front Immunol. 2020 Jul 22;11:1477. doi: 10.3389/fimmu.2020.01477. PMID: 32793202; PMCID: PMC7387408.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7387408/
649. Krause KM, Serio AW, Kane TR, Connolly LE. Aminoglycosides: An Overview. Cold Spring Harb Perspect Med. 2016 Jun 1;6(6):a027029. doi: 10.1101/cshperspect.a027029. PMID: 27252397; PMCID: PMC4888811.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4888811/
650. Jose M. Lopez-Novoa, Yaremi Quiros, Laura Vicente, Ana I. Morales, Francisco J. Lopez-Hernandez, New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view, Kidney International, Volume 79, Issue 1, 2011, Pages 33-45, ISSN 0085-2538, https://doi.org/10.1038/ki.2010.337.
https://www.sciencedirect.com/science/article/pii/S0085253815546760
651. Swan SK. Aminoglycoside nephrotoxicity. Semin Nephrol. 1997 Jan;17(1):27-33. PMID: 9000547.
https://pubmed.ncbi.nlm.nih.gov/9000547/
652. Dobrek, L. A Synopsis of Current Theories on Drug-Induced Nephrotoxicity. Life 2023, 13, 325. https://doi.org/10.3390/life13020325
https://www.mdpi.com/2075-1729/13/2/325
653. Staging liver fibrosis and cirrhosis using non-invasive tests in people with chronic hepatitis B to inform WHO 2024 guidelines: a systematic review and meta-analysis Liguori, Antonio et al. The Lancet Gastroenterology & Hepatology, Volume 10, Issue 4, 332 - 349
https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00437-0/fulltext
654. Ji Huang, Yongqi Liu, Youshun Liu, Antiviral therapy in hepatitis B virus-infected with immune-tolerant: A meta-analysis, Gastroenterología y Hepatología (English Edition), Volume 46, Issue 4, 2023, Pages 309-318, ISSN 2444-3824, https://doi.org/10.1016/j.gastre.2022.05.011.
https://www.sciencedirect.com/science/article/abs/pii/S2444382423000706
655. Parikh P, Ryan JD, Tsochatzis EA. Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection. Ann Transl Med. 2017 Feb;5(3):40. doi: 10.21037/atm.2017.01.28. PMID: 28251119; PMCID: PMC5326648.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5326648/
656. You, H., Wang, X., Ma, L. et al. Insights into the impact of hepatitis B virus on hepatic stellate cell activation. Cell Commun Signal 21, 70 (2023). https://doi.org/10.1186/s12964-023-01091-7
https://biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01091-7
657. Bedossa P. Reversibility of hepatitis B virus cirrhosis after therapy: who and why? Liver Int. 2015 Jan;35 Suppl 1:78-81. doi: 10.1111/liv.12710. PMID: 25529091.
https://pubmed.ncbi.nlm.nih.gov/25529091/
658. Yameng Sun, Xiaoning Wu, Jialing Zhou, Tongtong Meng, Bingqiong Wang, Shuyan Chen, Hui Liu, Tailing Wang, Xinyan Zhao, Shanshan Wu, Yuanyuan Kong, Xiaojuan Ou, Aileen Wee, Neil D. Theise, Chao Qiu, Wenhong Zhang, Fengmin Lu, Jidong Jia, Hong You, Persistent Low Level of Hepatitis B Virus Promotes Fibrosis Progression During Therapy, Clinical Gastroenterology and Hepatology, Volume 18, Issue 11, 2020, Pages 2582-2591.e6, ISSN 1542-3565, https://doi.org/10.1016/j.cgh.2020.03.001.
https://www.sciencedirect.com/science/article/pii/S154235652030272X
659. Soares AA, de Sá-Nakanishi AB, Bracht A, da Costa SM, Koehnlein EA, de Souza CG, Peralta RM. Hepatoprotective effects of mushrooms. Molecules. 2013 Jul 1;18(7):7609-30. doi: 10.3390/molecules18077609. PMID: 23884116; PMCID: PMC6270077.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6270077/
660. Bhatia, Aditya & Neeraj, Dr. (2024). Medicinal Mushrooms: A promising frontier in hepatitis treatment. 05. 19-24.
https://www.researchgate.net/publication/380721790_Medicinal_Mushrooms_A_promising_frontier_in_hepatitis_treatment
661. Abramyan S, Hanlon M. Kidney Transplantation. [Updated 2023 Jan 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK567755/
662. Patrick Yoon Kim, Azarin Shoghi, Ghaneh Fananapazir, Renal Transplantation: Immediate and Late Complications, Radiologic Clinics of North America, Volume 61, Issue 5, 2023, Pages 809-820, ISSN 0033-8389, ISBN 9780443181771, https://doi.org/10.1016/j.rcl.2023.04.004.
https://www.sciencedirect.com/science/article/abs/pii/S0033838923001161
663. Naik RH, Shawar SH. Renal Transplantation Rejection. [Updated 2023 Feb 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK553074/
664. The National Kidney Federation, What is transplant rejection? March 2023
https://www.kidney.org.uk/what-is-transplant-rejection
665. Weinrauch LA, Claggett B, Liu J, Finn PV, Weir MR, Weiner DE, D'Elia JA. Smoking and outcomes in kidney transplant recipients: a post hoc survival analysis of the FAVORIT trial. Int J Nephrol Renovasc Dis. 2018 Apr 27;11:155-164. doi: 10.2147/IJNRD.S161001. PMID: 29760559; PMCID: PMC5937486.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5937486/
666. Salamah, Sovia1; Gomes Neto, Antonio Wouter1; Alkaff, Firas F.1,2; Kootstra-Ros, Jenny E.1; Touw, Daniel J.1; Franssen, Casper F.M.1; Bakker, Stephan J.L.1. Carboxyhemoglobin and Smoking Status in Kidney Transplant Recipients: TH-PO791. Journal of the American Society of Nephrology 35(10S):10.1681/ASN.2024s9tskgx2, October 2024. | DOI: 10.1681/ASN.2024s9tskgx2
https://journals.lww.com/jasn/fulltext/2024/10001/carboxyhemoglobin_and_smoking_status_in_kidney.1114.aspx
667. Christie Rampersad, Jason Bau, Ani Orchanian-Cheff, S. Joseph Kim, Impact of donor smoking history on kidney transplant recipient outcomes: A systematic review and meta-analysis, Transplantation Reviews, Volume 38, Issue 3, 2024, 100854, ISSN 0955-470X, https://doi.org/10.1016/j.trre.2024.100854.
https://www.sciencedirect.com/science/article/pii/S0955470X24000375
668. Khalil MAM, Tan J, Khamis S, Khalil MA, Azmat R, Ullah AR. Cigarette Smoking and Its Hazards in Kidney Transplantation. Adv Med. 2017;2017:6213814. doi: 10.1155/2017/6213814. Epub 2017 Jul 27. PMID: 28819637; PMCID: PMC5551477.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5551477/
669. Sara T. Stoler, Maria Chan, Steven J. Chadban, Nutrition in the Management of Kidney Transplant Recipients, Journal of Renal Nutrition, Volume 33, Issue 6, Supplement, 2023, Pages S67-S72, ISSN 1051-2276, https://doi.org/10.1053/j.jrn.2023.07.001.
https://www.sciencedirect.com/science/article/abs/pii/S1051227623001085
670. Stoler ST, Chan M, Chadban SJ. Nutrition in the Management of Kidney Transplant Recipients. J Ren Nutr. 2023 Nov;33(6S):S67-S72. doi: 10.1053/j.jrn.2023.07.001. Epub 2023 Jul 22. PMID: 37482148.
https://pubmed.ncbi.nlm.nih.gov/37482148/
671. Azer SA, Hashmi MF, Reddivari AKR. Gastroesophageal Reflux Disease (GERD) [Updated 2024 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK554462/
672. Shaqran TM, Ismaeel MM, Alnuaman AA, Al Ahmad FA, Albalawi GA, Almubarak JN, AlHarbi RS, Alaqidi RS, AlAli YA, Alfawaz KS, Daghriri AA. Epidemiology, Causes, and Management of Gastro-esophageal Reflux Disease: A Systematic Review. Cureus. 2023 Oct 21;15(10):e47420. doi: 10.7759/cureus.47420. PMID: 38022211; PMCID: PMC10658748.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10658748/
673. Nirwan, J.S., Hasan, S.S., Babar, ZUD. et al. Global Prevalence and Risk Factors of Gastro-oesophageal Reflux Disease (GORD): Systematic Review with Meta-analysis. Sci Rep 10, 5814 (2020). https://doi.org/10.1038/s41598-020-62795-1
https://www.nature.com/articles/s41598-020-62795-1
674. Baklola, M., Terra, M., Badr, A. et al. Prevalence of gastro-oesophageal reflux disease, and its associated risk factors among medical students: a nation-based cross-sectional study. BMC Gastroenterol 23, 269 (2023). https://doi.org/10.1186/s12876-023-02899-w
https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-023-02899-w
675. Zhang D, Liu S, Li Z, Wang R. Global, regional and national burden of gastroesophageal reflux disease, 1990-2019: update from the GBD 2019 study. Ann Med. 2022 Dec;54(1):1372-1384. doi: 10.1080/07853890.2022.2074535. PMID: 35579516; PMCID: PMC9122392.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9122392/
676. Eivind Ness-Jensen, Jesper Lagergren, Tobacco smoking, alcohol consumption and gastro-oesophageal reflux disease, Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 5, 2017, Pages 501-508, ISSN 1521-6918, https://doi.org/10.1016/j.bpg.2017.09.004.
https://www.sciencedirect.com/science/article/abs/pii/S1521691817300999
677. Yen P-C, Geng J-H, Wu P-Y, Huang J-C, Hu H-M, Kuo C-H and Chen S-C (2024) Secondhand smoke is associated with peptic ulcer disease and gastroesophageal reflux disease in non-smokers in a large Taiwanese population study. Front. Public Health. 12:1450481. doi: 10.3389/fpubh.2024.1450481
https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1450481/full
678. Gomm W, von Holt K, Thomé F, et al. Association of Proton Pump Inhibitors With Risk of Dementia: A Pharmacoepidemiological Claims Data Analysis. JAMA Neurol. 2016;73(4):410–416. doi:10.1001/jamaneurol.2015.4791
https://jamanetwork.com/journals/jamaneurology/fullarticle/2487379
679. Ortiz-Guerrero G, Amador-Muñoz D, Calderón-Ospina CA, López-Fuentes D, Nava Mesa MO. Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences. Neural Plast. 2018 Mar 21;2018:5257285. doi: 10.1155/2018/5257285. PMID: 29755512; PMCID: PMC5883984.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5883984/
680. Northuis CA, Bell EJ, Lutsey PL, George KM, Gottesman RF, Mosley TH, Whitsel EA, Lakshminarayan K. Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study. Neurology. 2023 Oct 31;101(18):e1771-e1778. doi: 10.1212/WNL.0000000000207747. Epub 2023 Aug 9. Erratum in: Neurology. 2024 Jul 9;103(1):e209596. doi: 10.1212/WNL.0000000000209596. PMID: 37558503; PMCID: PMC10634644.
https://www.neurology.org/doi/10.1212/WNL.0000000000207747
681. Common questions about esomeprazole, 7 January 2022 NHS of UK
https://www.nhs.uk/medicines/esomeprazole/common-questions-about-esomeprazole/
682. Published July 19, 2017 GASTROENTEROLOGY Proton Pump Inhibitors: Considerations With Long-Term Use, Emily M. Ambizas, PharmD, MPH, BCGP, Joseph V. Etzel, PharmD
https://www.uspharmacist.com/article/proton-pump-inhibitors-considerations-with-longterm-use
683. Maideen NMP. Adverse Effects Associated with Long-Term Use of Proton Pump Inhibitors. Chonnam Med J. 2023 May;59(2):115-127. doi: 10.4068/cmj.2023.59.2.115. Epub 2023 May 25. PMID: 37303818; PMCID: PMC10248387.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10248387/
684. Munir U, Tafti D, Morgan S. Morton Neuroma. [Updated 2023 May 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan
https://www.ncbi.nlm.nih.gov/books/NBK470249/
685. Potu, Bhagath & Saleem, Bader & Almarabheh, Amer. (2023). Prevalence of Morton’s toe and assessment of the associated risk factors: a cross-sectional study. European Journal of Anatomy. 717-722. 10.52083/ZOJG4094.
https://www.researchgate.net/publication/375178146_Prevalence_of_Morton%27s_toe_and_assessment_of_the_associated_risk_factors_a_cross-sectional_study
686. del Mar Ruiz-Herrera, M.; Criado-Álvarez, J.J.; Suarez-Ortiz, M.; Konschake, M.; Moroni, S.; Marcos-Tejedor, F. Study of the Anatomical Association between Morton’s Neuroma and the Space Inferior to the Deep Transverse Metatarsal Ligament Using Ultrasound. Diagnostics 2022, 12, 1367. https://doi.org/10.3390/diagnostics12061367
https://www.mdpi.com/2075-4418/12/6/1367
687. Symeonidis PD, Iselin LD, Simmons N, Fowler S, Dracopoulos G, Stavrou P. Prevalence of interdigital nerve enlargements in an asymptomatic population. Foot Ankle Int. 2012 Jul;33(7):543-7. doi: 10.3113/FAI.2012.0543. PMID: 22835390.
https://pubmed.ncbi.nlm.nih.gov/22835390/
This suggests that a significant portion of the population may have radiologically visible Morton's neuromas, even if they aren't experiencing symptoms.
688. What is a Morton’s neuroma? June 6, 2024, uclahealth
https://www.uclahealth.org/news/article/what-mortons-neuroma
689. Matthews BG, Thomson CE, McKinley JC, Harding MP, Ware RS. Treatments for Morton's neuroma. Cochrane Database Syst Rev. 2021 Jul 14;2021(7):CD014687. doi: 10.1002/14651858.CD014687. PMCID: PMC8277559.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8277559/
690. Naik RH, Shawar SH. Renal Transplantation Rejection. 2023 Feb 9. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 31971715.
https://pubmed.ncbi.nlm.nih.gov/31971715/
691. Justiz Vaillant AA, Misra S, Fitzgerald BM. Acute Transplantation Rejection. [Updated 2024 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK535410/
692. Maria Sandovici, Leo E. Deelman, Dick de Zeeuw, Harry van Goor, Robert H. Henning, Immune modulation and graft protection by gene therapy in kidney transplantation, European Journal of Pharmacology, Volume 585, Issues 2–3, 2008, Pages 261-269, ISSN 0014-2999, https://doi.org/10.1016/j.ejphar.2008.02.087.
https://www.sciencedirect.com/science/article/abs/pii/S0014299908002811
693. Oweira H, Ramouz A, Ghamarnejad O, Khajeh E, Ali-Hasan-Al-Saegh S, Nikbakhsh R, Reißfelder C, Rahbari N, Mehrabi A, Sadeghi M. Risk Factors of Rejection in Renal Transplant Recipients: A Narrative Review. J Clin Med. 2022 Mar 3;11(5):1392. doi: 10.3390/jcm11051392. PMID: 35268482; PMCID: MC8911293.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8911293/
694. Alasfar, S.; Kodali, L.; Schinstock, C.A. Current Therapies in Kidney Transplant Rejection. J. Clin. Med. 2023, 12, 4927. https://doi.org/10.3390/jcm12154927
https://www.mdpi.com/2077-0383/12/15/4927
695. Aref A, Sharma A, Halawa A. Smoking in Renal Transplantation; Facts Beyond Myth. World J Transplant. 2017 Apr 24;7(2):129-133. doi: 10.5500/wjt.v7.i2.129. PMID: 28507915; PMCID: PMC5409912.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5409912/
696 Arnaud Devresse, Sophie Gohy, Arnaud Robert, Nada Kanaan, How to manage cigarette smoking in kidney transplant candidates and recipients?, Clinical Kidney Journal, Volume 14, Issue 11, November 2021, Pages 2295–2303, https://doi.org/10.1093/ckj/sfab072
https://academic.oup.com/ckj/article/14/11/2295/6204102
697. Simone A. Joosten, YVO W.J. Sijpkens, Cees van Kooten, Leendert C. Paul, Chronic renal allograft rejection: Pathophysiologic considerations, Kidney International, Volume 68, Issue 1, 2005, Pages 1-13, ISSN 0085-2538, https://doi.org/10.1111/j.1523-1755.2005.00376.x.
https://www.sciencedirect.com/science/article/pii/S0085253815508090
698. Sung RS, Althoen M, Howell TA, Ojo AO, Merion RM. Excess risk of renal allograft loss associated with cigarette smoking. Transplantation. 2001 Jun 27;71(12):1752-7. doi: 10.1097/00007890-200106270-00009. PMID: 11455254.
https://pubmed.ncbi.nlm.nih.gov/11455254/
699. Agarwal, P. K., Hellemons, M. E., Zelle, D. M., van Ree, R. M., van den Born, J., van der Heide, J. J. H., Gans, R. O. B., van Son, W. J., Navis, G., & Bakker, S. J. L. (2011). Smoking Is a Risk Factor for Graft Failure and Mortality after Renal Transplantation. American Journal of Nephrology, 34(1), 26-31. https://doi.org/10.1159/000328903
https://pure.eur.nl/en/publications/smoking-is-a-risk-factor-for-graft-failure-and-mortality-after-re
700. Nourbala, Mohammad & Nemati, Eghlim & Rostami, Zohreh & Einollahi, Behzad. (2011). Impact of Cigarette Smoking on Kidney Transplant Recipients A Systematic Review. Iranian journal of kidney diseases. 5. 141-8.
https://www.researchgate.net/publication/51082216_Impact_of_Cigarette_Smoking_on_Kidney_Transplant_Recipients_A_Systematic_Review
701. Agarwal PK, Hellemons ME, Zelle DM, van Ree RM, van den Born J, van der Heide JJ, Gans RO, van Son WJ, Navis G, Bakker SJ. Smoking is a risk factor for graft failure and mortality after renal transplantation. Am J Nephrol. 2011;34(1):26-31. doi: 10.1159/000328903. Epub 2011 Jun 9. PMID: 21659736.
https://pubmed.ncbi.nlm.nih.gov/21659736/
702. Shamsudheen, M. P.; Kuchay, Abid; Gupta, Vijay Chander; Tiwari, Isha; Karthik, Raja,*; Das, Uttara; Guditi, Swarnalatha; Taduri, Gangadhar. Allograft Rejection in Kidney Transplantation – A Retrospective Study of Impact on Graft and Patient Outcome. Indian Journal of Transplantation 16(4):p 371-376, Oct–Dec 2022. | DOI: 10.4103/ijot.ijot_93_21
https://journals.lww.com/ijjt/fulltext/2022/16040/allograft_rejection_in_kidney_transplantation___a.4.aspx
703. Cyrino LG, Galpern J, Moore L, Borgi L, Riella LV. A Narrative Review of Dietary Approaches for Kidney Transplant Patients. Kidney Int Rep. 2021 Apr 27;6(7):1764-1774. doi: 10.1016/j.ekir.2021.04.009. PMID: 34307973; PMCID: PMC8258457.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8258457/
704. Abdulla K. Salahudeen, Thomas H. Hostetter, Susan K. Raatz, Mark E. Rosenberg, Effects of dietary protein in patients with chronic renal transplant rejection, Kidney International, Volume 41, Issue 1, 1992, Pages 183-190, ISSN 0085-2538, https://doi.org/10.1038/ki.1992.25.
https://www.sciencedirect.com/science/article/pii/S0085253815574462
705. Sengupta P, Chaudhuri A, Rathore K, Biswas S. Nutritional management of kidney transplant recipient. Proceedings of Singapore Healthcare. 2025;34. doi:10.1177/20101058251327810
https://journals.sagepub.com/doi/10.1177/20101058251327810
706. Meade E, Hehir S, Rowan N, Garvey M. Mycotherapy: Potential of Fungal Bioactives for the Treatment of Mental Health Disorders and Morbidities of Chronic Pain. J Fungi (Basel). 2022 Mar 11;8(3):290. doi: 10.3390/jof8030290. PMID: 35330292; PMCID: PMC8954642.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8954642/
707. Amaya-Amaya J, Rojas-Villarraga A, Mantilla RD, et al. Rheumatoid arthritis. In: Anaya JM, Shoenfeld Y, Rojas-Villarraga A, et al., editors. Autoimmunity: From Bench to Bedside [Internet]. Bogota (Colombia): El Rosario University Press; 2013 Jul 18. Chapter 24. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459454/
708. Venetsanopoulou AI, Alamanos Y, Voulgari PV, Drosos AA. Epidemiology and Risk Factors for Rheumatoid Arthritis Development. Mediterr J Rheumatol. 2023 Dec 30;34(4):404-413. doi: 10.31138/mjr.301223.eaf. PMID: 38282942; PMCID: PMC10815538.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10815538/
709. Safiri S, Kolahi AA, Hoy D, Smith E, Bettampadi D, Mansournia MA, Almasi-Hashiani A, Ashrafi-Asgarabad A, Moradi-Lakeh M, Qorbani M, Collins G, Woolf AD, March L, Cross M. Global, regional and national burden of rheumatoid arthritis 1990-2017: a systematic analysis of the Global Burden of Disease study 2017. Ann Rheum Dis. 2019 Nov;78(11):1463-1471. doi: 10.1136/annrheumdis-2019-215920. Epub 2019 Sep 11. PMID: 31511227.
https://pubmed.ncbi.nlm.nih.gov/31511227/
710. Panagopoulos PK, Lambrou GI. Bone erosions in rheumatoid arthritis: recent developments in pathogenesis and therapeutic implications. J Musculoskelet Neuronal Interact. 2018 Sep 1;18(3):304-319. PMID: 30179207; PMCID: PMC6146189.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6146189/
711. InformedHealth.org [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. Rheumatoid arthritis: Learn More – Fatigue related to rheumatoid arthritis. [Updated 2024 Jan 11].
https://www.ncbi.nlm.nih.gov/books/NBK384467/
712. Smolen JS, Landewé RBM, Bergstra SA, Kerschbaumer A, Sepriano A, Aletaha D, Caporali R, Edwards CJ, Hyrich KL, Pope JE, de Souza S, Stamm TA, Takeuchi T, Verschueren P, Winthrop KL, Balsa A, Bathon JM, Buch MH, Burmester GR, Buttgereit F, Cardiel MH, Chatzidionysiou K, Codreanu C, Cutolo M, den Broeder AA, El Aoufy K, Finckh A, Fonseca JE, Gottenberg JE, Haavardsholm EA, Iagnocco A, Lauper K, Li Z, McInnes IB, Mysler EF, Nash P, Poor G, Ristic GG, Rivellese F, Rubbert-Roth A, Schulze-Koops H, Stoilov N, Strangfeld A, van der Helm-van Mil A, van Duuren E, Vliet Vlieland TPM, Westhovens R, van der Heijde D. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update. Ann Rheum Dis. 2023 Jan;82(1):3-18. doi: 10.1136/ard-2022-223356. Epub 2022 Nov 10. Erratum in: Ann Rheum Dis. 2023 Mar;82(3):e76. doi: 10.1136/ard-2022-223356corr1. PMID: 36357155.
https://pubmed.ncbi.nlm.nih.gov/36357155/
713. Mohamed H. Babiker-Mohamed, Sambhawana Bhandari, Prabha Ranganathan, Pharmacogenetics of therapies in rheumatoid arthritis: An update, Best Practice & Research Clinical Rheumatology, Volume 38, Issue 4, 2024, 101974, ISSN 1521-6942, https://doi.org/10.1016/j.berh.2024.101974.
https://www.sciencedirect.com/science/article/pii/S1521694224000457
714. Shakeel, Laiba MBBSa; Shaukat, Ayesha MBBSa; Khaliq, Nawal MBBSa; Kashif, Aayat MBBSb; Mujeeb, Azka MBBSb; Adnan, Zahabia MBBSb; Taj, Javeria MBBSa; Akilimali, Aymar MDc. Rheumatoid arthritis: a comprehensive overview of genetic markers, emerging therapies, and personalized medicine. Annals of Medicine & Surgery 87(2):p 696-710, February 2025. | DOI: 10.1097/MS9.0000000000002890
https://journals.lww.com/annals-of-medicine-and-surgery/fulltext/2025/02000/rheumatoid_arthritis__a_comprehensive_overview_of.35.aspx
715. Hoenders R, Ghelman R, Portella C, Simmons S, Locke A, Cramer H, Gallego-Perez D, Jong M. A review of the WHO strategy on traditional, complementary, and integrative medicine from the perspective of academic consortia for integrative medicine and health. Front Med (Lausanne). 2024 Jun 11;11:1395698. doi: 10.3389/fmed.2024.1395698. PMID: 38933107; PMCID: PMC11201178.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11201178/
716. Integrating Traditional Medicine in Health Care 30 January 2023, WHO
https://www.who.int/southeastasia/news/feature-stories/detail/integrating-traditional-medicine
717. Prasad S, Aggarwal BB. Turmeric, the Golden Spice: From Traditional Medicine to Modern Medicine. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 13.
https://www.ncbi.nlm.nih.gov/books/NBK92752/
718. Plant-Based Drugs and Medicines, Dr. Liji Thomas, MDBy Dr. Liji Thomas, MD, Reviewed by Emily Henderson, B.Sc., News-Medical.net
https://www.news-medical.net/health/Plant-Based-Drugs-and-Medicines.aspx
719. Chaachouay, N.; Zidane, L. Plant-Derived Natural Products: A Source for Drug Discovery and Development. Drugs Drug Candidates 2024, 3, 184-207. https://doi.org/10.3390/ddc3010011
https://www.mdpi.com/2813-2998/3/1/11
720. Victoria P (2023) Utilizing the Healing Power of Medicinal Plants. Med Aromat Plant. 12:456
https://www.longdom.org/open-access/utilizing-the-healing-power-of-medicinal-plants-103632.html
721. Wachtel-Galor S, Benzie IFF. Herbal Medicine: An Introduction to Its History, Usage, Regulation, Current Trends, and Research Needs. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 1.
https://www.ncbi.nlm.nih.gov/books/NBK92773/
722. integrative medicine, National Cancer Institute
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/integrative-medicine
723. GBD 2017 Diet Collaborators. Health effects of dietary risks in 195 countries, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2019 May 11;393(10184):1958-1972. doi: 10.1016/S0140-6736(19)30041-8. Epub 2019 Apr 4. Erratum in: Lancet. 2021 Jun 26;397(10293):2466. PMID: 30954305; PMCID: PMC6899507.
https://www.thelancet.com/article/S0140-6736(19)30041-8/fulltext
724. US Burden of Disease Collaborators, Mokdad AH, Ballestros K, et al. The State of US Health, 1990-2016: Burden of Diseases, Injuries, and Risk Factors Among US States. JAMA. 2018 Apr;319(14):1444-1472. DOI: 10.1001/jama.2018.0158. PMID: 29634829; PMCID: PMC5933332.
https://europepmc.org/article/MED/29634829
725. Why Good Nutrition is Important, Center for Science in the Public Interest
https://www.cspinet.org/eating-healthy/why-good-nutrition-important
726. Kaczorowski J, Campbell NR, Duhaney T, Mang E, Gelfer M. Reducing deaths by diet: Call to action for a public policy agenda for chronic disease prevention. Can Fam Physician. 2016 Jun;62(6):469-70. PMID: 27302998; PMCID: PMC4907549.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907549/
727. Bad diets responsible for 11 million premature deaths globally per year, 08th April 2019, The NCD Alliance
https://ncdalliance.org/news-events/news/bad-diets-responsible-for-11-million-premature-deaths-globally-per-year
728. DeeDee Stiepan Mayo Clinic Minute: Relationship between food, disease stronger than you may think January 30, 2023
https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-minute-mayo-clinic-minute-relationship-between-food-disease-stronger-than-you-may-think/
729. Wang DD, Li Y, Afshin A, Springmann M, Mozaffarian D, Stampfer MJ, Hu FB, Murray CJL, Willett WC. Global Improvement in Dietary Quality Could Lead to Substantial Reduction in Premature Death. J Nutr. 2019 Jun 1;149(6):1065-1074. doi: 10.1093/jn/nxz010. PMID: 31049577; PMCID: PMC6543201.
https://www.sciencedirect.com/science/article/pii/S0022316622166307
730. May 19, 2021 / Nutrition A Poor Diet Increases Your Risk of Dying from Heart Disease, Stroke, Diabetes, Cleveland Clinic
https://health.clevelandclinic.org/a-poor-diet-increases-your-risk-of-dying-from-heart-disease-stroke-diabetes/
731. Akbar Rijia, Raman Krishnamoorthi, Muthuramalingam Kaviyadharshini, Pambayan Ulagan Mahalingam, Unlocking fungal fortunes: Cutting-edge extraction techniques and therapeutic possibilities of mushroom bioactive compounds, Food Chemistry Advances, Volume 6, 2025, 100895, ISSN 2772-753X, https://doi.org/10.1016/j.focha.2025.100895.
https://www.sciencedirect.com/science/article/pii/S2772753X25000115
732. Singh, A.; Saini, R.K.; Kumar, A.; Chawla, P.; Kaushik, R. Mushrooms as Nutritional Powerhouses: A Review of Their Bioactive Compounds, Health Benefits, and Value-Added Products. Foods 2025, 14, 741. https://doi.org/10.3390/foods14050741
https://www.mdpi.com/2304-8158/14/5/741
733. Yadav SK, Ir R, Jeewon R, Doble M, Hyde KD, Kaliappan I, Jeyaraman R, Reddi RN, Krishnan J, Li M, Durairajan SSK. A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders. Planta Med. 2020 Nov;86(16):1161-1175. doi: 10.1055/a-1177-4834. Epub 2020 Jul 14. PMID: 32663897.
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1177-4834
734. Rašeta M, Popović M, Knežević P, Šibul F, Kaišarević S, Karaman M. Bioactive Phenolic Compounds of Two Medicinal Mushroom Species Trametes versicolor and Stereum subtomentosum as Antioxidant and Antiproliferative Agents. Chem Biodivers. 2020 Dec;17(12):e2000683. doi: 10.1002/cbdv.202000683. Epub 2020 Nov 17. PMID: 33058392.
https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202000683
735. Venturella, G.; Ferraro, V.; Cirlincione, F.; Gargano, M.L. Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials. Int. J. Mol. Sci. 2021, 22, 634. https://doi.org/10.3390/ijms22020634
https://www.mdpi.com/1422-0067/22/2/634
736. Shaffique, S.; Kang, S.-M.; Kim, A.-Y.; Imran, M.; Aaqil Khan, M.; Lee, I.-J. Current Knowledge of Medicinal Mushrooms Related to Anti-Oxidant Properties. Sustainability 2021, 13, 7948. https://doi.org/10.3390/su13147948
https://www.mdpi.com/2071-1050/13/14/7948
737. Hetland G, Johnson E, Bernardshaw SV, Grinde B. Can medicinal mushrooms have prophylactic or therapeutic effect against COVID-19 and its pneumonic superinfection and complicating inflammation? Scand J Immunol. 2021 Jan;93(1):e12937. doi: 10.1111/sji.12937. Epub 2020 Jul 29. PMID: 32657436; PMCID: PMC7404338.
https://onlinelibrary.wiley.com/doi/10.1111/sji.12937
738. Arthritis drug found in mushrooms, Nina Athey-Pollard, Royal Society of Chemistry
https://www.rsc.org/news/2005/july/arthritis-drug-found-in-mushrooms
739. Dennett CC, Simon J. The role of polycystic ovary syndrome in reproductive and metabolic health: overview and approaches for treatment. Diabetes Spectr. 2015 May;28(2):116-20. doi: 10.2337/diaspect.28.2.116. PMID: 25987810; PMCID: PMC4433074.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4433074/
740. May 15, 2024, Diabetes and Polycystic Ovary Syndrome (PCOS), u.s. centers for disease control and prevention
https://www.cdc.gov/diabetes/risk-factors/pcos-polycystic-ovary-syndrome.html
741. Scicchitano P, Dentamaro I, Carbonara R, Bulzis G, Dachille A, Caputo P, Riccardi R, Locorotondo M, Mandurino C, Matteo Ciccone M. Cardiovascular Risk in Women With PCOS. Int J Endocrinol Metab. 2012 Fall;10(4):611-8. doi: 10.5812/ijem.4020. Epub 2012 Sep 30. PMID: 23843832; PMCID: PMC3693634.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3693634/
742. Bishop KS, Kao CH, Xu Y, Glucina MP, Paterson RR, Ferguson LR. From 2000years of Ganoderma lucidum to recent developments in nutraceuticals. Phytochemistry. 2015 Jun;114:56-65. doi: 10.1016/j.phytochem.2015.02.015. Epub 2015 Mar 17. PMID: 25794896.
https://pubmed.ncbi.nlm.nih.gov/25794896/
743. Oke MA, Afolabi FJ, Oyeleke OO, Kilani TA, Adeosun AR, Olanbiwoninu AA and Adebayo EA (2022) Ganoderma lucidum: Unutilized natural medicine and promising future solution to emerging diseases in Africa. Front. Pharmacol. 13:952027. doi: 10.3389/fphar.2022.952027
https://www.frontiersin.org/articles/10.3389/fphar.2022.952027/full
744. Grienke U, Kaserer T, Pfluger F, et al. Accessing biological actions of Ganoderma secondary metabolites by in silico profiling. Phytochemistry. 2015 Jun;114:114-124. DOI: 10.1016/j.phytochem.2014.10.010. PMID: 25457486; PMCID: PMC4948669.
https://europepmc.org/article/MED/25457486
745. El Sheikha AF. Nutritional Profile and Health Benefits of Ganoderma lucidum "Lingzhi, Reishi, or Mannentake" as Functional Foods: Current Scenario and Future Perspectives. Foods. 2022 Apr 1;11(7):1030. doi: 10.3390/foods11071030. PMID: 35407117; PMCID: PMC8998036.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998036/
746. Ahmad MF, Ahmad FA, Khan MI, Alsayegh AA, Wahab S, Alam MI, Ahmed F. Ganoderma lucidum: A potential source to surmount viral infections through β-glucans immunomodulatory and triterpenoids antiviral properties. Int J Biol Macromol. 2021 Sep 30;187:769-779. doi: 10.1016/j.ijbiomac.2021.06.122. Epub 2021 Jun 29. PMID: 34197853.
https://pubmed.ncbi.nlm.nih.gov/34197853/
747. Saltarelli R, Palma F, Gioacchini AM, Calcabrini C, Mancini U, De Bellis R, Stocchi V, Potenza L. Phytochemical composition, antioxidant and antiproliferative activities and effects on nuclear DNA of ethanolic extract from an Italian mycelial isolate of Ganoderma lucidum. J Ethnopharmacol. 2019 Mar 1;231:464-473. doi: 10.1016/j.jep.2018.11.041. Epub 2018 Dec 1. PMID: 30513345.
https://pubmed.ncbi.nlm.nih.gov/30513345/
748. Anticancer Agents Med Chem. Author manuscript; available in PMC 2019 Jul 12. Published in final edited form as: Anticancer Agents Med Chem. 2018; 18(5): 667–674. Ganoderma lucidum Polysaccharides as an anti-cancer agent Didem Sohretoglu1,2 and Shile Huang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624854/
749. Ahmad MF, A Alsayegh A, Ahmad FA, Akhtar MS, Alavudeen SS, Bantun F, Wahab S, Ahmed A, Ali M, Elbendary EY, Raposo A, Kambal N, H Abdelrahman M. Ganoderma lucidum: Insight into antimicrobial and antioxidant properties with development of secondary metabolites. Heliyon. 2024 Feb 4;10(3):e25607. doi: 10.1016/j.heliyon.2024.e25607. PMID: 38356540; PMCID: PMC10865332.
https://www.sciencedirect.com/science/article/pii/S2405844024016384
750. Exp Ther Med. 2017 Oct;14(4):3273-3278. doi: 10.3892/etm.2017.4883. Epub 2017 Aug 3. Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors. Zheng DS1, Chen LS2.
https://pubmed.ncbi.nlm.nih.gov/28912878/
751. Valverde ME, Hernández-Pérez T, Paredes-López O. Edible mushrooms: improving human health and promoting quality life. Int J Microbiol. 2015;2015:376387. doi: 10.1155/2015/376387. Epub 2015 Jan 20. PMID: 25685150; PMCID: PMC4320875.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4320875/
752. Γρίπη και Εποχική Γρίπη, ΕΟΔΥ.
https://eody.gov.gr/disease/gripi-kai-epochiki-gripi/
753. The Flu: 3 Ways to Fight Back at 50-Plus, The Johns Hopkins University
https://www.hopkinsmedicine.org/health/conditions-and-diseases/influenza/the-flu-3-ways-to-fight-back-at-50-plus
754. Strengthen your immune system against seasonal illnesses December 17, 2024 Teresa Saenz
https://vitalrecord.tamu.edu/strengthen-your-immune-system-against-seasonal-illnesses
755. Allen EK, Thomas PG. Immunity to influenza. Preventing infection and regulating disease. Am J Respir Crit Care Med. 2015 Feb 1;191(3):248-51. doi: 10.1164/rccm.201412-2245ED. PMID: 25635487; PMCID: PMC4351582.
https://www.atsjournals.org/doi/full/10.1164/rccm.201412-2245ED
756. Zhang, Y.; Zhang, G.; Ling, J. Medicinal Fungi with Antiviral Effect. Molecules 2022, 27, 4457. https://doi.org/10.3390/molecules27144457
https://www.mdpi.com/1420-3049/27/14/4457
757. Medicinal Mushrooms: Fitness for Your Immune System, Aviva Romm, MD
https://avivaromm.com/medicinal-mushrooms-immune-system/
758. Manash Pratim Pathak, Kalyani Pathak, Riya Saikia, Urvashee Gogoi, Mohammad Zaki Ahmad, Pompy Patowary, Aparoop Das, Immunomodulatory effect of mushrooms and their bioactive compounds in cancer: A comprehensive review, Biomedicine & Pharmacotherapy, Volume 149, 2022, 112901, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2022.112901.
https://www.sciencedirect.com/science/article/pii/S0753332222002906
759. Vlasenko, Vyacheslav & Vlasenko, Anastasia & Turmunkh, Dejidmaa & Dondov, Budsuren. (2021). First Data on Antiviral Activity of Aqueous Extracts from Medicinal Mushrooms from the Altai Mountains in Russia against Influenza Virus Type A. International Journal of Medicinal Mushrooms. 23. 37-45.
https://www.researchgate.net/publication/356811510_First_Data_on_Antiviral_Activity_of_Aqueous_Extracts_from_Medicinal_Mushrooms_from_the_Altai_Mountains_in_Russia_against_Influenza_Virus_Type_A
760. Arunachalam K, Sasidharan SP, Yang X. A concise review of mushrooms antiviral and immunomodulatory properties that may combat against COVID-19. Food Chem Adv. 2022 Oct;1:100023. doi: 10.1016/j.focha.2022.100023. Epub 2022 Mar 2. PMID: 36686330; PMCID: PMC8887958.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8887958/
761. Seo DJ, Choi C. Antiviral Bioactive Compounds of Mushrooms and Their Antiviral Mechanisms: A Review. Viruses. 2021 Feb 23;13(2):350. doi: 10.3390/v13020350. PMID: 33672228; PMCID: PMC7926341.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7926341/
762. News New discovery could help protect against influenza, McGill University, 18/2/25
https://www.mcgill.ca/newsroom/channels/news/new-discovery-could-help-protect-against-influenza-363625
763. Hetland G, Johnson E, Bernardshaw SV, Grinde B. Can medicinal mushrooms have prophylactic or therapeutic effect against COVID-19 and its pneumonic superinfection and complicating inflammation?. Scand J Immunol. 2021; 93:e12937. https://doi.org/10.1111/sji.12937
https://onlinelibrary.wiley.com/doi/10.1111/sji.12937
764. MS Patient’s Pick of the Week’s News: Remyelination, Ocrevus, Mushrooms, Heparin, Exercise admin avatar by admin | October 17, 2016
https://multiplesclerosisnewstoday.com/ians-blog/2016/10/17/ms-patients-pick-weeks-news-remyelination-ocrevus-mushrooms-heparin-exercise/
765. Pourmohammadi G, Moghimi H. New approach of using medicinal mushrooms for managing and curing multiple sclerosis. Fitoterapia. 2025 Sep;185:106684. doi: 10.1016/j.fitote.2025.106684. Epub 2025 Jun 15. PMID: 40527388.
https://pubmed.ncbi.nlm.nih.gov/40527388/
766. Wang R, Sun H, Yang T, Xu J. Causal relationship between hypertension and risk of constipation: A 2-way 2-sample Mendelian randomization study. Medicine (Baltimore). 2024 May 3;103(18):e38057. doi: 10.1097/MD.0000000000038057. PMID: 38701266; PMCID: PMC11062663.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11062663/
767. Wang, Junwen, Ye, Yuyang, Chen, Xuefeng, Hu, Xinru, Peng, Yong, Constipation and Cardiovascular Mortality Risk in Patients With Hypertension: A Long-Term Cohort Study, International Journal of Hypertension, 2025, 9921027, 9 pages, 2025. https://doi.org/10.1155/ijhy/9921027
https://onlinelibrary.wiley.com/doi/10.1155/ijhy/9921027
768. Sumida K, Molnar MZ, Potukuchi PK, Thomas F, Lu JL, Yamagata K, Kalantar-Zadeh K, Kovesdy CP. Constipation and risk of death and cardiovascular events. Atherosclerosis. 2019 Feb;281:114-120. doi: 10.1016/j.atherosclerosis.2018.12.021. Epub 2018 Dec 23. PMID: 30658186; PMCID: PMC6399019.https://pmc.ncbi.nlm.nih.gov/articles/PMC6399019/
769. Liu B, Wu X, Wang Y, Hu X. Association between constipation and risk of cardiovascular or all-cause mortality: a meta-analysis. Ann Med. 2025 Dec;57(1):2561803. doi: 10.1080/07853890.2025.2561803. Epub 2025 Sep 22. PMID: 40982729; PMCID: PMC12456042.
https://pubmed.ncbi.nlm.nih.gov/40982729/
770. Biedroń, Rafał & Tangen, Jon-Magnus & Maresz, Katarzyna & Hetland, Geir. (2012). Agaricus blazei Murill - immunomodulatory properties and health benefits. Funct Foods Health Dis. 2. 428-447. 10.31989/ffhd.v2i11.72.
https://ffhdj.com/index.php/ffhd/article/view/72/162
771. TianX, Lun Z, Ito J.Clinical observation on treatment of acute non lymphocytic leukemia with Agaricus blazei. Lanzhou Med Coll 1994;20:169–171.
https://www.springboard4health.com/notebook/health_agaricus_6.html
772. Υπουργείο Αγροτικής Ανάπτυξης και Τροφίμων, Γενική Διεύθυνση Φυτικής Παραγωγής, Μανιτάρια
https://www.minagric.gr/images/stories/docs/agrotis/Aromatika_Fyta/Manitari_entypo_291211.pdf
773. Υπουργείο Παιδείας, Θρησκευμάτων και Αθλητισμού, Τριπτόλεμος, Πρόγραμμα,
https://www.minedu.gov.gr/publications/docs2016/250416_programms-endodima-manitaria.pdf
774. ΕΛΓΟ-ΔΗΜΗΤΡΑ: ΙΝΣΤΙΤΟΥΤΟ ΤΕΧΝΟΛΟΓΙΑΣ ΓΕΩΡΓΙΚΩΝ ΠΡΟΪΟΝΤΩΝ, ΕΡΓΑΣΤΗΡΙΟ ΕΔΩΔΙΜΩΝ & ΦΑΡΜΑΚΕΥΤΙΚΩΝ ΜΥΚΗΤΩΝ, Δρ. Αντώνης Φιλιππούσης Γεωπόνος - Μυκητολόγος Τακτικός Ερευνητής
https://www.e-kyklades.gr/images/10Epistrofi_Filippoysis_F29952.pdf
775. Uffelman CN, Doenges KA, Armstrong ML, Quinn K, Reisdorph RM, Tang M, Krebs NF, Reisdorph NA, Campbell WW. Metabolomics Profiling of White Button, Crimini, Portabella, Lion's Mane, Maitake, Oyster, and Shiitake Mushrooms Using Untargeted Metabolomics and Targeted Amino Acid Analysis. Foods. 2023 Aug 8;12(16):2985. doi: 10.3390/foods12162985. PMID: 37627983; PMCID: PMC10453450.
https://pubmed.ncbi.nlm.nih.gov/37627983/
Προσαρμογόνα
1. Chugh RM, Mittal P, Mp N, Arora T, Bhattacharya T, Chopra H, Cavalu S, Gautam RK. Fungal Mushrooms: A Natural Compound With Therapeutic Applications. Front Pharmacol. 2022 Jul 13;13:925387. doi: 10.3389/fphar.2022.925387. PMID: 35910346; PMCID: PMC9328747.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9328747/
2. Adaptogenic or Medicinal Mushrooms, Published April 20, 2009, M. Saljoughian, PharmD, PhD Alta Bates Summit Medical Center Department of Pharmacy Services Berkeley, California,
https://www.uspharmacist.com/article/adaptogenic-or-medicinal-mushrooms
3. Adaptogens, Cleveland Clinic, Last reviewed on 02/10/2022.
https://my.clevelandclinic.org/health/drugs/22361-adaptogens
4. What are adaptogens and should you be taking them? February 16, 2022 By uclahealth,
https://www.uclahealth.org/news/article/what-are-adaptogens-and-should-you-be-taking-them
5. Medicinal Mushrooms and their history of therapeutic uses, Sophie Barrett, Medical Herbalist, Naturopath, Faculty of Homeopathy
https://www.facultyofhomeopathy.org/events/medicinal-mushrooms-their-history-of-therapeutic-uses
6. Bocharova OA. Adaptogeny kak sredstva profilakticheskoĭ onkologii [Adaptogens as agents for prophylactic oncology]. Vestn Ross Akad Med Nauk. 1999;(5):49-53. Russian. PMID: 10394302.
https://pubmed.ncbi.nlm.nih.gov/10394302/
7. Panossian A, Wikman G, Kaur P, Asea A. Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones. Phytomedicine. 2009 Jun;16(6-7):617-22. doi: 10.1016/j.phymed.2008.12.003. Epub 2009 Feb 1. PMID: 19188053.
https://pubmed.ncbi.nlm.nih.gov/19188053
8. Khanum F, Bawa AS, Singh B. Rhodiola rosea: A Versatile Adaptogen. Compr Rev Food Sci Food Saf. 2005 Jul;4(3):55-62. doi: 10.1111/j.1541-4337.2005.tb00073.x. PMID: 33430554.
https://pubmed.ncbi.nlm.nih.gov/33430554/
9. Blyumin-Karasik M, Colon J, Nguyen S, Rosen J. Laser and Skin-Care Synergy: A Post-Laser Application of Novel Adaptogenic Moisturizing Serum for Improving Healing and Cosmesis on the Face. J Cosmet Dermatol. 2024 Nov 6. doi: 10.1111/jocd.16668. Epub ahead of print. PMID: 39503217.
https://pubmed.ncbi.nlm.nih.gov/39503217/
10. Liu XX, Chen CY, Li L, Guo MM, He YF, Meng H, Dong YM, Xiao PG, Yi F. Bibliometric Study of Adaptogens in Dermatology: Pharmacophylogeny, Phytochemistry, and Pharmacological Mechanisms. Drug Des Devel Ther. 2023 Feb 6;17:341-361. doi: 10.2147/DDDT.S395256. PMID: 36776447; PMCID: PMC9912821.
https://pubmed.ncbi.nlm.nih.gov/36776447/
11. KrishnaRaju AV, Somepalli V, Thanawala S, Shah R. Efficacy and Anti-Inflammatory Activity of Ashwagandha Sustained-Release Formulation on Depression and Anxiety Induced by Chronic Unpredictable Stress: in vivo and in vitro Studies. J Exp Pharmacol. 2023 Jul 25;15:291-305. doi: 10.2147/JEP.S407906. PMID: 37521489; PMCID: PMC10386834.
https://pubmed.ncbi.nlm.nih.gov/37521489/
12. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012 Jul;34(3):255-62. doi: 10.4103/0253-7176.106022. PMID: 23439798; PMCID: PMC3573577.
https://pubmed.ncbi.nlm.nih.gov/23439798/
13. Okoh L, Ajayi AM, Ben-Azu B, Akinluyi ET, Emokpae O, Umukoro S. D-Ribose-L-cysteine exhibits adaptogenic-like activity through inhibition of oxido-inflammatory responses and increased neuronal caspase-3 activity in mice exposed to unpredictable chronic mild stress. Mol Biol Rep. 2020 Oct;47(10):7709-7722. doi: 10.1007/s11033-020-05845-1. Epub 2020 Sep 21. PMID: 32959196.
https://pubmed.ncbi.nlm.nih.gov/32959196/
14. Wróbel-Biedrawa D, Podolak I. Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review. Molecules. 2024 Feb 15;29(4):866. doi: 10.3390/molecules29040866. PMID: 38398618; PMCID: PMC10891670.
https://pubmed.ncbi.nlm.nih.gov/38398618/
15. Panossian A. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals. Ann N Y Acad Sci. 2017 Aug;1401(1):49-64. doi: 10.1111/nyas.13399. Epub 2017 Jun 22. PMID: 28640972.
https://pubmed.ncbi.nlm.nih.gov/28640972
16. Thakur, Dr. Ajit & Chatterjee, Shyam & Kumar, Vikas. (2014). Andrographolides and traditionally used Andrographis paniculata as potential adaptogens: Implications for therapeutic innovation. TANG (Humanitas Medicine). 4. 15.1-15.14. 10.5667/tang.2014.0002.
https://www.researchgate.net/publication/269577319_Andrographolides_and_traditionally_used_Andrographis_paniculata_as_potential_adaptogens_Implications_for_therapeutic_innovation
1. Panossian, Alexander & H, Wagener. (2011). Adaptogens. A Review of their History, Biological Activity, and Clinical Benefits.. Herbal Gram. 90.
https://www.researchgate.net/publication/236462312_Adaptogens_A_Review_of_their_History_Biological_Activity_and_Clinical_Benefits/citation/download
2. A general Endobiogenic approach to regulation of the immune system Kamyar M. Hedayat, Jean-Claude Lapraz, in The Theory of Endobiogeny, 2019
https://www.sciencedirect.com/topics/medicine-and-dentistry/adaptogen
3. Panossian, A.; Wikman, G. Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress—Protective Activity. Pharmaceuticals 2010, 3, 188-224. https://doi.org/10.3390/ph3010188
https://www.mdpi.com/1424-8247/3/1/188
4. Liao LY, He YF, Li L, Meng H, Dong YM, Yi F, Xiao PG. A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide. Chin Med. 2018 Nov 16;13:57. doi: 10.1186/s13020-018-0214-9. PMID: 30479654; PMCID: PMC6240259.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240259/
5. Abate M, Pepe G, Randino R, Pisanti S, Basilicata MG, Covelli V, Bifulco M, Cabri W, D'Ursi AM, Campiglia P, Rodriquez M. Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury. Pharmaceuticals (Basel). 2020 Aug 29;13(9):224. doi: 10.3390/ph13090224. PMID: 32872510; PMCID: PMC7557611.
https://pubmed.ncbi.nlm.nih.gov/32872510/
6. Sagar SM, Yance D, Wong RK. Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 2. Curr Oncol. 2006 Jun;13(3):99-107. PMID: 17576449; PMCID: PMC1891180.
https://pubmed.ncbi.nlm.nih.gov/17576449/
7. Sagar SM, Yance D, Wong RK. Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 1. Curr Oncol. 2006 Feb;13(1):14-26. PMID: 17576437; PMCID: PMC1891166.
https://pubmed.ncbi.nlm.nih.gov/17576437/
8. Yance DR Jr, Sagar SM. Targeting angiogenesis with integrative cancer therapies. Integr Cancer Ther. 2006 Mar;5(1):9-29. doi: 10.1177/1534735405285562. PMID: 16484711.
https://pubmed.ncbi.nlm.nih.gov/16484711/
9. Panossian A. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals. Ann N Y Acad Sci. 2017 Aug;1401(1):49-64. doi: 10.1111/nyas.13399. Epub 2017 Jun 22. PMID: 28640972.
https://pubmed.ncbi.nlm.nih.gov/28640972/
10. Sulaiman MK, Lakshmanan J. Systemic and Anticancer Potential of Adaptogenic Constituents Isolated from Traditional Herbs - A Mini-Review. Anticancer Agents Med Chem. 2022 Aug 4;22(16):2811-2821. doi: 10.2174/1871520622666220408091610. PMID: 35400325.
https://pubmed.ncbi.nlm.nih.gov/35400325/
11. Kaur P, Robin, Makanjuola VO, Arora R, Singh B, Arora S. Immunopotentiating significance of conventionally used plant adaptogens as modulators in biochemical and molecular signalling pathways in cell mediated processes. Biomed Pharmacother. 2017 Nov;95:1815-1829. doi: 10.1016/j.biopha.2017.09.081. Epub 2017 Oct 6. PMID: 28968926.
https://pubmed.ncbi.nlm.nih.gov/28968926/
12. Seo EJ, Klauck SM, Efferth T, Panossian A. Adaptogens in chemobrain (Part I): Plant extracts attenuate cancer chemotherapy-induced cognitive impairment - Transcriptome-wide microarray profiles of neuroglia cells. Phytomedicine. 2019 Mar 1;55:80-91. doi: 10.1016/j.phymed.2018.10.022. Epub 2018 Oct 19. PMID: 30668446.
https://pubmed.ncbi.nlm.nih.gov/30668446/
13. Diwanay S, Gautam M, Patwardhan B. Cytoprotection and immunomodulation in cancer therapy. Curr Med Chem Anticancer Agents. 2004 Nov;4(6):479-90. doi: 10.2174/1568011043352704. PMID: 15579014.
https://pubmed.ncbi.nlm.nih.gov/15579014/
14. Seo EJ, Klauck SM, Efferth T, Panossian A. Adaptogens in chemobrain (Part III): Antitoxic effects of plant extracts towards cancer chemotherapy-induced toxicity - transcriptome-wide microarray analysis of neuroglia cells. Phytomedicine. 2019 Mar 15;56:246-260. doi: 10.1016/j.phymed.2018.11.011. Epub 2018 Nov 9. PMID: 30668345.
https://pubmed.ncbi.nlm.nih.gov/30668345/
15. Bocharova OA. Adaptogeny kak sredstva profilakticheskoĭ onkologii [Adaptogens as agents for prophylactic oncology]. Vestn Ross Akad Med Nauk. 1999;(5):49-53. Russian. PMID: 10394302.
https://pubmed.ncbi.nlm.nih.gov/10394302/
16. Panossian, A.; Wikman, G. Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress—Protective Activity. Pharmaceuticals 2010, 3, 188-224. https://doi.org/10.3390/ph3010188
https://www.mdpi.com/1424-8247/3/1/188
Ωμέγα 3
1. Fitsum, S., D. B.Sbhatu, and G.Gebreyohannes. 2025. “Harnessing the Nutritional Value, Therapeutic Applications, and Environmental Impact of Mushrooms.” Food Science & Nutrition13, no. 7: e70611. https://doi.org/10.1002/fsn3.70611.
https://onlinelibrary.wiley.com/doi/10.1002/fsn3.70611
2. Rui Yeong Tan, Zul Ilham, Wan Abd Al Qadr Imad Wan-Mohtar, Sarina Abdul Halim-Lim, Siti Rokhiyah Ahmad Usuldin, Rahayu Ahmad, Muhammad Adlim, Mushroom oils: A review of their production, composition, and potential applications, Heliyon, Volume 10, Issue 11, 2024, e31594, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2024.e31594.
https://www.sciencedirect.com/science/article/pii/S2405844024076254
3. Denise Sande, Geane Pereira de Oliveira, Marília Aparecida Fidelis e Moura, Bruna de Almeida Martins, Matheus Thomaz Nogueira Silva Lima, Jacqueline Aparecida Takahashi, Edible mushrooms as a ubiquitous source of essential fatty acids, Food Research International, Volume 125, 2019, 108524, ISSN 0963-9969, https://doi.org/10.1016/j.foodres.2019.108524.
https://www.sciencedirect.com/science/article/pii/S0963996919303953
4. Dimopoulou, M.; Kolonas, A.; Mourtakos, S.; Androutsos, O.; Gortzi, O. Nutritional Composition and Biological Properties of Sixteen Edible Mushroom Species. Appl. Sci. 2022, 12, 8074. https://doi.org/10.3390/app12168074
https://www.mdpi.com/2076-3417/12/16/8074
5. Gustavo Waltzer Fehrenbach, Robert Pogue, Frank Carter, Eoghan Clifford, Neil Rowan, Implications for the seafood industry, consumers and the environment arising from contamination of shellfish with pharmaceuticals, plastics and potentially toxic elements: A case study from Irish waters with a global orientation, Science of The Total Environment, Volume 844, 2022, 157067, ISSN 0048-9697, https://doi.org/10.1016/j.scitotenv.2022.157067.
https://www.sciencedirect.com/science/article/pii/S004896972204164X?via%3Dihub
Δισμουτάση του υπεροξειδίου
1. Xie, Y., Gu, Y., Li, Z. et al. Effects of exercise on different antioxidant enzymes and related indicators: a systematic review and meta-analysis of randomized controlled trials. Sci Rep 15, 12518 (2025). https://doi.org/10.1038/s41598-025-97101-4
https://www.nature.com/articles/s41598-025-97101-4
2. Zheng M, Liu Y, Zhang G, Yang Z, Xu W, Chen Q. The Applications and Mechanisms of Superoxide Dismutase in Medicine, Food, and Cosmetics. Antioxidants (Basel). 2023 Aug 27;12(9):1675. doi: 10.3390/antiox12091675. PMID: 37759978; PMCID: PMC10525108.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10525108/
3. Lei XG, Zhu JH, Cheng WH, Bao Y, Ho YS, Reddi AR, Holmgren A, Arnér ES. Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications. Physiol Rev. 2016 Jan;96(1):307-64. doi: 10.1152/physrev.00010.2014. PMID: 26681794; PMCID: PMC4839492.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4839492/
4. Xueqin Li, Xingqi Cao, Zhimin Ying, Guangtao Yang, Emiel O Hoogendijk, Zuyun Liu, Plasma superoxide dismutase activity in relation to disability in activities of daily living and objective physical functioning among Chinese older adults, Maturitas, Volume 161, 2022, Pages 12-17, ISSN 0378-5122, https://doi.org/10.1016/j.maturitas.2022.01.018.
https://www.sciencedirect.com/science/article/abs/pii/S0378512222000238
5. Research Article | Volume 15 Issue 5 (May, 2025) | Pages 789 - 792 Estimation Of Antioxidant Enzyme Levels in Individuals with Regular and Irregular Sleep Patterns Kalola Akshaybhai Ramjibhai 1 , Aghara Harshilkumar Arvindbhai 2 , Detroja Milan Yogeshbhai 2 , Bloch M Asfaq Firozbhai
https://healthcare-bulletin.co.uk/article/estimation-of-antioxidant-enzyme-levels-in-individuals-with-regular-and-irregular-sleep-patterns-3482/
6. Segal, Lauren M. and Wilson, Richard A., "Reactive oxygen species metabolism and plant-fungal interactions" (2018). Papers in Plant Pathology. 573. https://digitalcommons.unl.edu/plantpathpapers/573
7. Buettner GR, Ng CF, Wang M, Rodgers VG, Schafer FQ. A new paradigm: manganese superoxide dismutase influences the production of H2O2 in cells and thereby their biological state. Free Radic Biol Med. 2006 Oct 15;41(8):1338-50. doi: 10.1016/j.freeradbiomed.2006.07.015. Epub 2006 Jul 21. PMID: 17015180; PMCID: PMC2443724.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2443724/
8. Aaron C. Asensio, Miriam Gil-Monreal, Laura Pires, Yolanda Gogorcena, Pedro María Aparicio-Tejo, Jose Fernando Moran, Two Fe-superoxide dismutase families respond differently to stress and senescence in legumes, Journal of Plant Physiology, Volume 169, Issue 13, 2012, Pages 1253-1260, ISSN 0176-1617, https://doi.org/10.1016/j.jplph.2012.04.019.
https://www.sciencedirect.com/science/article/abs/pii/S0176161712002398
9. Ismy, J., Sugandi, S., Rachmadi, D., Hardjowijoto, S., & Mustafa, A. (2020). The Effect of Exogenous Superoxide Dismutase (SOD) on Caspase-3 Activation and Apoptosis Induction in Pc-3 Prostate Cancer Cells. Research and Reports in Urology, 12, 503–508. https://doi.org/10.2147/RRU.S271203
https://www.tandfonline.com/doi/full/10.2147/RRU.S271203#d1e272
10. I. Rahman, S.K. Biswas, OXIDANTS AND ANTIOXIDANTS | Antioxidants, Enzymatic, Editor(s): Geoffrey J. Laurent, Steven D. Shapiro, Encyclopedia of Respiratory Medicine, Academic Press, 2006, Pages 258-266, ISBN 9780123708793, https://doi.org/10.1016/B0-12-370879-6/00283-0.
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/superoxide-dismutase
11. Ighodaro, O. M., & Akinloye, O. A. (2018). First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria Journal of Medicine, 54(4), 287–293. https://doi.org/10.1016/j.ajme.2017.09.001
https://www.tandfonline.com/doi/full/10.1016/j.ajme.2017.09.001#d1e515
12. Monday, July 24, 2023, Superoxide Dismutase Purported Benefits, Side Effects & More, Memorial Sloan Kettering Cancer Center
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/superoxide-dismutase
13. Dreyer, B.H. and Schippers, J.H.M. (2019). Copper-Zinc Superoxide Dismutases in Plants: Evolution, Enzymatic Properties, and Beyond. In Annual Plant Reviews online, J.A. Roberts (Ed.). https://doi.org/10.1002/9781119312994.apr0705
https://onlinelibrary.wiley.com/doi/10.1002/9781119312994.apr0705
14. Gopal RK, Elumalai S (2017) Industrial Production of Superoxide Dismutase (SOD): A Mini Review. J Prob Health 5:179.
https://www.longdom.org/open-access/industrial-production-of-superoxide-dismutase-sod-a-mini-review-36663.html
15. Geng, Ping, Siu, Ka-Chai, Wang, Zhaomei, Wu, Jian-Yong, Antifatigue Functions and Mechanisms of Edible and Medicinal Mushrooms, BioMed Research International, 2017, 9648496, 16 pages, 2017. https://doi.org/10.1155/2017/9648496
https://onlinelibrary.wiley.com/doi/10.1155/2017/9648496
16. Venturella G, Ferraro V, Cirlincione F, Gargano ML. Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials. Int J Mol Sci. 2021 Jan 10;22(2):634. doi: 10.3390/ijms22020634. PMID: 33435246; PMCID: PMC7826851.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7826851/
17. Kim MY, Seguin P, Ahn JK, Kim JJ, Chun SC, Kim EH, Seo SH, Kang EY, Kim SL, Park YJ, Ro HM, Chung IM. Phenolic compound concentration and antioxidant activities of edible and medicinal mushrooms from Korea. J Agric Food Chem. 2008 Aug 27;56(16):7265-70. doi: 10.1021/jf8008553. Epub 2008 Jul 11. PMID: 18616260.
https://pubs.acs.org/doi/10.1021/jf8008553
18. Guang Yu Cheng, Jun Liu, Ming Xuan Tao, Chang Mei Lu, Guo Rong Wu, Activity, thermostability and isozymes of superoxide dismutase in 17 edible mushrooms, Journal of Food Composition and Analysis, Volume 26, Issues 1–2, 2012, Pages 136-143, ISSN 0889-1575, https://doi.org/10.1016/j.jfca.2012.01.001.
https://www.sciencedirect.com/science/article/abs/pii/S0889157512000142
19. Aritson Cruz, Lígia Pimentel, Luis M. Rodríguez-Alcalá, Tito Fernandes, Manuela Pintado. Health Benefits of Edible Mushrooms Focused on Coriolus versicolor: A Review. Journal of Food and Nutrition Research. Vol. 4, No. 12, 2016, pp 773-781. https://pubs.sciepub.com/jfnr/4/12/2
https://ciencia.ucp.pt/ws/files/120409009/49220515.pdf
20. Emma Camilleri, Renald Blundell, Bikash Baral, Tomasz M. Karpinski, Edlira Aruci, Omar M. Atrooz, A brief overview of the medicinal and nutraceutical importance of Inonotus obliquus (chaga) mushrooms, Heliyon, Volume 10, Issue 15, 2024, e35638, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2024.e35638.
https://www.sciencedirect.com/science/article/pii/S2405844024116696
21. Mircea, Cosmin & Cioanca, Oana & Bild, Veronica & Iancu, C. & Stan, Catalina & Hancianu, Monica. (2018). In vivo antioxidant properties of some mushroom extracts in experimentally induced diabetes. Farmacia. 66. 257-261.
https://farmaciajournal.com/arhiva/201802/art-09-Mircea_Cioanca_Hancianu_257-261.pdf
22. Podkowa, A., Kryczyk-Poprawa, A., Opoka, W. et al. Culinary–medicinal mushrooms: a review of organic compounds and bioelements with antioxidant activity. Eur Food Res Technol 247, 513–533 (2021). https://doi.org/10.1007/s00217-020-03646-1
https://link.springer.com/article/10.1007/s00217-020-03646-1
23. Pigoń-Zając, D.; Małecka-Massalska, T.; Łapiński, J.; Prendecka-Wróbel, M. Modern Pro-Health Applications of Medicinal Mushrooms: Insights into the Polyporaceae Family, with a Focus on Cerrena unicolor. Molecules 2025, 30, 4089. https://doi.org/10.3390/molecules30204089
https://www.mdpi.com/1420-3049/30/20/4089
24. Itrat, Nizwa & Hasanath, Seinul & Ali, Akhtar. (2025). Mushrooms as Natural Antioxidants and Their Role in Oxidative Stress Management. 10.1007/978-3-032-00789-6_3.
https://www.researchgate.net/publication/396047472_Mushrooms_as_Natural_Antioxidants_and_Their_Role_in_Oxidative_Stress_Management
25. Luo J, Ganesan K, Xu B. Unlocking the Power: New Insights into the Anti-Aging Properties of Mushrooms. J Fungi (Basel). 2024 Mar 14;10(3):215. doi: 10.3390/jof10030215. PMID: 38535223; PMCID: PMC10970926.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10970926/
26. Zhang, J.-J.; Li, Y.; Zhou, T.; Xu, D.-P.; Zhang, P.; Li, S.; Li, H.-B. Bioactivities and Health Benefits of Mushrooms Mainly from China. Molecules 2016, 21, 938. https://doi.org/10.3390/molecules21070938
https://www.mdpi.com/1420-3049/21/7/938
27. ASHD 2020;19(1):27-35 2020 Ankara Üniversitesi Araştırma Makalesi/Research Article ISSN: 2667-6044 27 Biochemical evaluation of commercially available Reishi Supplement Against The Enzymes On Oxidation And Phosphorylation of Cellular Proteins. Fırat Ayan; Beste C. Bilen*; Belgin S. İşgör
https://dergipark.org.tr/en/download/article-file/1481711
28. Dharmasanti, Olivia & Iswar, Ida & Praharsini, IGAA & Muliarta, I & Widianti, I & Wahyuniari, Ida. (2023). Shiitake Mushroom Extract (Lentinus Edodes) Increases Superoxide Dismutase Levels and Collagen Quantity in Male Wistar Strain Rats (Rattus Norvegicus) Exposed to Ultraviolet B Light. International Journal of Research Publication and Reviews. 4. 1550-1555. 10.55248/gengpi.4.923.92447.
https://www.researchgate.net/publication/374343555_Shiitake_Mushroom_Extract_Lentinus_Edodes_Increases_Superoxide_Dismutase_Levels_and_Collagen_Quantity_in_Male_Wistar_Strain_Rats_Rattus_Norvegicus_Exposed_to_Ultraviolet_B_Light
29. Choi, Se-Jin & Lee, Yeon-Sil & Kim, Jin-Kyung & Kim, Jin-Kyu & Lim, Soon. (2010). Physiological Activities of Extract from Edible Mushrooms. Journal of the Korean Society of Food Science and Nutrition. 39. 10.3746/jkfn.2010.39.8.1087.
https://www.researchgate.net/publication/264016424_Physiological_Activities_of_Extract_from_Edible_Mushrooms
30. Barros A. B, Bell V, Ferrão J, Calabrese V, Fernandes T. H. Mushroom Biomass: Some Clinical Implications of β-Glucans and Enzymes. Curr Res Nutr Food Sci 2016;4(Special Issue Confernce October 2016).
https://www.foodandnutritionjournal.org/vol04nospl-issue-conf-october-2016/mushroom-biomass-some-clinical-implications-of-%CE%B2-glucans-and-enzymes/
31. Kozarski M, Klaus A, Jakovljevic D, Todorovic N, Vunduk J, Petrović P, Niksic M, Vrvic MM, van Griensven L. Antioxidants of Edible Mushrooms. Molecules. 2015 Oct 27;20(10):19489-525. doi: 10.3390/molecules201019489. PMID: 26516828; PMCID: PMC6331815.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6331815/
ΕΡΙΚΙΟ ΤΟ ΑΓΚΑΘΩΤΟ και ΗΠΑΡ"
1. Hao L, Xie Y, Wu G, Cheng A, Liu X, Zheng R, Huo H, Zhang J. Protective Effect of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evid Based Complement Alternat Med. 2015;2015:418023. doi: 10.1155/2015/418023. Epub 2015 Apr 16. PMID: 25960751; PMCID: PMC4415743.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415743/
2. Cui, F., Gao, X., Zhang, J. et al. Protective Effects of Extracellular and Intracellular Polysaccharides on Hepatotoxicity by Hericium erinaceus SG-02. Curr Microbiol 73, 379–385 (2016). https://doi.org/10.1007/s00284-016-1073-1
https://link.springer.com/article/10.1007/s00284-016-1073-1
3. Lianchi Wu, Zhaoying Hu, Yujie Lv, Chaoyue Ge, Xinyu Luo, Shenao Zhan, Weichen Huang, Xinyu Shen, Dongyou Yu, Bing Liu, Hericium erinaceus polysaccharides ameliorate nonalcoholic fatty liver disease via gut microbiota and tryptophan metabolism regulation in an aged laying hen model, International ournal of Biological Macromolecules, Volume 273, Part 1, 2024, 132735, ISSN 0141-8130, https://doi.org/10.1016/j.ijbiomac.2024.132735.
https://www.sciencedirect.com/science/article/abs/pii/S0141813024035402
4. Hericium erinaceus Mushroom Extracts Protect Infected Mice against Salmonella Typhimurium-Induced Liver Damage and Mortality by Stimulation of Innate Immune Cells Sung Phil Kim, Eunpyo Moon, Seok Hyun Nam, and Mendel Friedman Journal of Agricultural and Food Chemistry 2012 60 (22), 5590-5596 DOI: 10.1021/jf300897w
https://pubs.acs.org/doi/10.1021/jf300897w
5. Zhang, C., Li, J., Hu, C. et al. Antihyperglycaemic and organic protective effects on pancreas, liver and kidney by polysaccharides from Hericium erinaceus SG-02 in streptozotocin-induced diabetic mice. Sci Rep 7, 10847 (2017). https://doi.org/10.1038/s41598-017-11457-w
https://www.nature.com/articles/s41598-017-11457-w
6. Kim SP, Nam SH, Friedman M. Hericium erinaceus (Lion's Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26 colon cancer-tansplanted mice. J Agric Food Chem. 2013 May 22;61(20):4898-904. doi: 10.1021/jf400916c. Epub 2013 May 13. Erratum in: J Agric Food Chem. 2013 Jun 5;61(22):5411. Erratum in: J Agric Food Chem. 2014 Jan 15;62(2):528. PMID: 23668749.
https://www.ars.usda.gov/research/publications/publication/?seqNo115=295111
7. ΕΡΊΚΙΟ ΤΟ ΑΓΚΑΘΩΤΌ, Ιωάννης Κιούσης, Στέλεχος Διατροφής και Διαιτολογίας.
https://www.farmakeftikamanitaria.gr/erikio-to-agkathwto.html
8. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK547852/
https://www.ncbi.nlm.nih.gov/books/NBK547852/
9. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Categorization Of The Likelihood Of Drug Induced Liver Injury. [Updated 2019 May 4]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK548392/
https://www.ncbi.nlm.nih.gov/books/NBK548392/
10. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Lion’s Mane. [Updated 2024 Jan 5]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK599740/
https://www.ncbi.nlm.nih.gov/books/NBK599740/
Τί είναι η μυκοθεραπεία;
1. Molecules. 2019 Oct 24;24(21). Quercetin Synergistically Inhibit EBV-Associated Gastric Carcinoma with Ganoderma lucidum Extracts. Huh S, Lee S, Choi SJ, Wu Z, Cho JH, Kim L, Shin YS, Kang BW, Kim JG, Liu K, Cho H, Kang H.
http://europepmc.org/article/MED/31653035
2. Oncotarget. 2018 May 15;9(37):24837-24856. 2018 May 15. B-glucans from Grifola frondosa and Ganoderma lucidum in breast cancer: an example of complementary and integrative medicine. Rossi P, Difrancia R, Quagliariello V, Savino E, Tralongo P, Randazzo CL, Berretta M.
http://europepmc.org/article/MED/29872510
3. Int J Med Mushrooms. 2019;21(2):105-119. Cancer without Pharmacological Illusions and a Niche for Mycotherapy (Review). Zmitrovich IV, Belova NV, Balandaykin ME, Bondartseva MA, Wasser SP
https://pubmed.ncbi.nlm.nih.gov/30806218/
https://www.researchgate.net/publication/330527416_Cancer_without_pharmacological_illusions_and_a_niche_for_mycotherapy
4. Oncotarget, 9 (49), 29259-29274 2018 Jun 26 Medicinal Mushrooms as an Attractive New Source of Natural Compounds for Future Cancer Therapy Artem Blagodatski, Margarita Yatsunskaya, Valeriia Mikhailova, Vladlena Tiasto, Alexander Kagansky, Vladimir L Katanaev
https://pubmed.ncbi.nlm.nih.gov/30018750/
http://europepmc.org/article/MED/30018750
5. Curr Top Med Chem, 13 (21), 2791-806 2013 Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of Their Action Višnja Popović, Jelena Živković, Slobodan Davidović, Milena Stevanović, Dejan Stojković
https://pubmed.ncbi.nlm.nih.gov/24083788
6. Int J Med Mushrooms, 19 (4), 279-317 2017 Medicinal Mushrooms in Human Clinical Studies. Part I. Anticancer, Oncoimmunological, and Immunomodulatory Activities: A Review Solomon P Wasser
https://pubmed.ncbi.nlm.nih.gov/28605319
7. Biomed J, 37 (6), 345-56 Nov-Dec 2014 Medicinal Mushroom Science: Current Perspectives, Advances, Evidences, and Challenges Solomon P Wasser
https://pubmed.ncbi.nlm.nih.gov/25179726
8. Compendium of Mycotherapy Beate Berg Natural Medicine Centre, Witten, Germany Jan I. Lelley GAMU Ltd. Institute for Mushroom Research Hüttenallee 241, D-47800 Krefeld, Germany
https://www.begellhouse.com/pt/books/5a65edb04853cf0d.html
9. Mushrooms—Mycotherapy and Mycochemistry , Prof. Dr. Jasmina Glamočlija, Dr. Dejan Stojković, MDPI
https://www.mdpi.com/journal/jof/special_issues/mushrooms_mycotherapy
Διγοξίνη
1. Zhu JS, Halpern GM, Jones K. The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med. 1998 Fall;4(3):289-303. doi: 10.1089/acm.1998.4.3-289. PMID: 9764768.
https://pubmed.ncbi.nlm.nih.gov/9764768/
2. American Herbal Products Association's Botanical Safety Handbook 2nd Edition by Zoë Gardner (Editor), Michael McGuffin (Editor
https://www.amazon.com/American-Products-Associations-Botanical-Handbook/dp/1466516941
https://books.google.gr/books?id=UdcZ2bttXaMC&pg=PA269&lpg=PA269&dq=cordyceps+digoxin&source=bl&ots=4u7H7VHfW8&sig=ACfU3U1R4hojAOeU5WYEWkbsqdn6dp578A&hl=el&sa=X&ved=2ahUKEwigxO7Z-qWGAxVWZ_EDHQQJAX04PBDoAXoECAkQAw#v=onepage&q=cordyceps%20digoxin&f=false
3. Rizal, Ardian & Sandra, Ferry & Rizki Fadlan, Muhamad & Sargowo, Djanggan. (2020). Ganoderma lucidum Polysaccharide Peptide Reduce Inflammation and Oxidative Stress in Patient with Atrial Fibrillation. The Indonesian Biomedical Journal. 12. 384-389. 10.18585/inabj.v12i4.1244.
https://www.researchgate.net/publication/347449665_Ganoderma_lucidum_Polysaccharide_Peptide_Reduce_Inflammation_and_Oxidative_Stress_in_Patient_with_Atrial_Fibrillation
Παιδιά
1. Lion's Mane: Everything You Need to Know By Megan Nunn, PharmD, June 29, 2023, Medically reviewed by Elizabeth Barnes, RDN
https://www.verywellhealth.com/lions-mane-benefits-and-nutrition-profile-7498004
2. Winder, Mateusz, Bulska-Będkowska, Weronika and Chudek, Jerzy. "The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology" Acta Pharmaceutica, vol.71, no.1, 2021, pp.1-16. https://doi.org/10.2478/acph-2021-0007
https://sciendo.com/article/10.2478/acph-2021-0007
Ερίκιο και Αντιαιμοπεταλιακή Αγωγή
1. Mori K, Kikuchi H, Obara Y, Iwashita M, Azumi Y, Kinugasa S, Inatomi S, Oshima Y, Nakahata N. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010 Dec 1;17(14):1082-5. doi: 10.1016/j.phymed.2010.05.004. Epub 2010 Jul 16. PMID: 20637576.
https://pubmed.ncbi.nlm.nih.gov/20637576/
2. GRAS Notification for the intended use of Lion's Mane mushroom p-glucans as a Food Ingredient, FDA, December 2, 2022
https://www.fda.gov/media/173805/download
3. Lion's Mane Mushroom, Medically reviewed by Drugs.com. Last updated on Nov 21, 2023.
https://www.drugs.com/npp/lion-s-mane-mushroom.htm
Ερίκιο παρενέργειες
1. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Lion’s Mane. [Updated 2024 Jan 5].
https://www.ncbi.nlm.nih.gov/books/NBK599740/
2. Lewis JE, Poles J, Shaw DP, Karhu E, Khan SA, Lyons AE, Sacco SB, McDaniel HR. The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. J Clin Transl Res. 2021 Aug 4;7(4):575-620. PMID: 34541370; PMCID: PMC8445631.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445631/
3. What evidence is there on the negative effects of lions mane mushroom supplements? Insight from top 3 papers
https://typeset.io/questions/what-evidence-is-there-on-the-negative-effects-of-lions-mane-57ff3q1lc6
4. Lion's Mane Mushroom, Drugs.com, Nov 21, 2023
https://www.drugs.com/npp/lion-s-mane-mushroom.html#side-effects
5. Chen SN, Chang CS, Yang MF, Chen S, Soni M, Mahadevan B. Subchronic toxicity and genotoxicity studies of Hericium erinaceus β-glucan extract preparation. Curr Res Toxicol. 2022 Mar 11;3:100068. doi: 10.1016/j.crtox.2022.100068. PMID: 35341120; PMCID: PMC8942846.
https://www.sciencedirect.com/science/article/pii/S2666027X22000056
6. Li IC, Chen YL, Lee LY, Chen WP, Tsai YT, Chen CC, Chen CS. Evaluation of the toxicological safety of erinacine A-enriched Hericium erinaceus in a 28-day oral feeding study in Sprague-Dawley rats. Food Chem Toxicol. 2014 Aug;70:61-7. doi: 10.1016/j.fct.2014.04.040. Epub 2014 May 6. PMID: 24810469.
https://pubmed.ncbi.nlm.nih.gov/24810469/
7. Park ID, Yoo HS, Lee YW, Son CG, Kwon M, Sung HJ, Cho CK. Toxicological study on MUNOPHIL, water extract of Panax ginseng and Hericium erinaceum in rats. J Acupunct Meridian Stud. 2008 Dec;1(2):121-7. doi: 10.1016/S2005-2901(09)60032-7. PMID: 20633464.
https://pubmed.ncbi.nlm.nih.gov/20633464/
8. Li IC, Lee LY, Tzeng TT, et al. Neurohealth Properties of <i>Hericium erinaceus</i> Mycelia Enriched with Erinacines. Behavioural Neurology. 2018;2018:5802634. DOI: 10.1155/2018/5802634. PMID: 29951133; PMCID: PMC5987239.
https://europepmc.org/article/MED/29951133
9. Li I-C, Chang H-H, Lin C-H, Chen W-P, Lu T-H, Lee L-Y, Chen Y-W, Chen Y-P, Chen C-C and Lin DP-C (2020) Prevention of Early Alzheimer’s Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study. Front. Aging Neurosci. 12:155. doi: 10.3389/fnagi.2020.00155
https://www.frontiersin.org/articles/10.3389/fnagi.2020.00155/full
10. Muhanna, M., Lund, I., Bromberg, M., Wicks, P., Benatar, M., Barnes, B., … Li, X. (2024). ALSUntangled #73: Lion’s Mane. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 25(3–4), 420–423. https://doi.org/10.1080/21678421.2023.2296557
https://www.tandfonline.com/doi/full/10.1080/21678421.2023.2296557
Β12
1.Tuli HS, Sandhu SS, Sharma AK. Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin. 3 Biotech. 2014 Feb;4(1):1-12. doi: 10.1007/s13205-013-0121-9. Epub 2013 Feb 19. PMID: 28324458; PMCID: PMC3909570.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909570/
2. Savioli, Fellipe & Zogaib, Paulo & Franco, Eduardo & Salles, Fernando & Giorelli, Guilherme & Andreoli, Carlos. (2022). Effects of Cordyceps Sinensis Supplementation during 12 weeks in amateur marathoners: a randomized, double-blind placebo-controlled trial. Journal of Herbal Medicine. 34. 100570. 10.1016/j.hermed.2022.100570.
https://www.sciencedirect.com/science/article/abs/pii/S2210803322000392
3. Annals of Agri-Bio Research 27 (2) : 149-152, 2022 , Standardization of Parameters for the Mycelium Growth of Hericium erinaceus : An Edible Medicinal Mushroom, SAKSHI KHURANA, ARVIND, VIKASH KUMAR1, JAGDEEP SINGH2,# AND ANIL SINDHU
https://www.cabidigitallibrary.org/doi/pdf/10.5555/20220527076
4. Teng F, Bito T, Takenaka S, Yabuta Y, Watanabe F. Vitamin B12[c-lactone], a biologically inactive corrinoid compound, occurs in cultured and dried lion's mane mushroom (Hericium erinaceus) fruiting bodies. J Agric Food Chem. 2014 Feb 19;62(7):1726-32. doi: 10.1021/jf404463v. Epub 2014 Feb 7. PMID: 24506286.
https://pubmed.ncbi.nlm.nih.gov/24506286/
5. Lion's Mane Mushroom, Drugs.com,
https://www.drugs.com/npp/lion-s-mane-mushroom.html
1. PDQ® Integrative, Alternative, and Complementary Therapies Editorial Board. PDQ Medicinal Mushrooms. Bethesda, MD: National Cancer Institute. Updated July 11, 2024. Available at: https://www.cancer.gov/about-cancer/treatment/cam/patient/mushrooms-pdq. Accessed 30/12/2025. [PMID: 28267306]
2. Łysakowska P, Sobota A, Wirkijowska A. Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review. Molecules. 2023 Jul 14;28(14):5393. doi: 10.3390/molecules28145393. PMID: 37513265; PMCID: PMC10384337.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10384337/
3. Venturella G, Ferraro V, Cirlincione F, Gargano ML. Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials. Int J Mol Sci. 2021 Jan 10;22(2):634. doi: 10.3390/ijms22020634. PMID: 33435246; PMCID: PMC7826851.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7826851/
4. Aaron Katz, Chapter 11 - Alternative Medicine for Prostate Cancer: Diet, Vitamins, Minerals, and Supplements, Editor(s): Li-Ming Su, Early Diagnosis and Treatment of Cancer Series: Prostate Cancer, W.B. Saunders, 2010, Pages 207-228, ISBN 9781416045755, https://doi.org/10.1016/B978-1-4160-4575-5.50017-7.
https://www.sciencedirect.com/science/article/abs/pii/B9781416045755500177
5. Aviva Romm, CHAPTER 10 - Breast Cancer, Editor(s): Aviva Romm, Mary L. Hardy, Simon Mills, Botanical Medicine for Women's Health, Churchill Livingstone, 2010, Pages 306-320, ISBN 9780443072772, https://doi.org/10.1016/B978-0-443-07277-2.00012-X.
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/medicinal-mushroom
6. W.G. Jiang, A.J. Sanders, M. Katoh, H. Ungefroren, F. Gieseler, M. Prince, S.K. Thompson, M. Zollo, D. Spano, P. Dhawan, D. Sliva, P.R. Subbarayan, M. Sarkar, K. Honoki, H. Fujii, A.G. Georgakilas, A. Amedei, E. Niccolai, A. Amin, S.S. Ashraf, L. Ye, W.G. Helferich, X. Yang, C.S. Boosani, G. Guha, M.R. Ciriolo, K. Aquilano, S. Chen, A.S. Azmi, W.N. Keith, A. Bilsland, D. Bhakta, D. Halicka, S. Nowsheen, F. Pantano, D. Santini, Tissue invasion and metastasis: Molecular, biological and clinical perspectives, Seminars in Cancer Biology, Volume 35, Supplement, 2015, Pages S244-S275, ISSN 1044-579X, https://doi.org/10.1016/j.semcancer.2015.03.008.
https://www.sciencedirect.com/science/article/pii/S1044579X15000231
7. Venturella G, Ferraro V, Cirlincione F, Gargano ML. Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials. Int J Mol Sci. 2021 Jan 10;22(2):634. doi: 10.3390/ijms22020634. PMID: 33435246; PMCID: PMC7826851.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7826851/
8. Łysakowska P, Sobota A, Wirkijowska A. Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review. Molecules. 2023 Jul 14;28(14):5393. doi: 10.3390/molecules28145393. PMID: 37513265; PMCID: PMC10384337.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10384337/
9. Lam CS, Cheng LP, Zhou LM, Cheung YT, Zuo Z. Herb-drug interactions between the medicinal mushrooms Lingzhi and Yunzhi and cytotoxic anticancer drugs: a systematic review. Chin Med. 2020 Jul 25;15:75. doi: 10.1186/s13020-020-00356-4. PMID: 32724333; PMCID: PMC7382813.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7382813/
10. Łysakowska P, Sobota A, Wirkijowska A. Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review. Molecules. 2023 Jul 14;28(14):5393. doi: 10.3390/molecules28145393. PMID: 37513265; PMCID: PMC10384337.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10384337/
11. WebMD, Reishi Mushroom - Uses, Side Effects, and More
https://www.webmd.com/vitamins/ai/ingredientmono-905/reishi-mushroom
12. Economically Motivated Adulteration (Food Fraud), FDA
https://www.fda.gov/food/compliance-enforcement-food/economically-motivated-adulteration-food-fraud
13. Sujogya Kumar Panda, Walter Luyten, Medicinal mushrooms: Clinical perspective and challenges, Drug Discovery Today, Volume 27, Issue 2, 2022, Pages 636-651, ISSN 1359-6446, https://doi.org/10.1016/j.drudis.2021.11.017.
https://www.sciencedirect.com/science/article/abs/pii/S1359644621004980
14. Medicinal Mushroom Market Research Report Information By Type (Reishi, Maitake, Shiitake, Chaga, Cordyceps, Turkey Tail, and Other Types), By Form (Fresh, Dried, and Other Form), By Function (Antioxidant, Immune Enhancer, Anti-Cancer, Skin Care, and Other Functions) And By Region (North America, Europe, Asia-Pacific, And Rest Of The World) –Market Forecast Till 2034
https://www.marketresearchfuture.com/reports/medicinal-mushroom-market-5556
15. La Monica MB, Raub B, Ziegenfuss EJ, Hartshorn S, Grdic J, Gustat A, Sandrock J, Ziegenfuss TN. Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion's Mane Extracts on Cognitive Performance. Nutrients. 2023 Dec 6;15(24):5018. doi: 10.3390/nu15245018. PMID: 38140277; PMCID: PMC10745489.
https://pubmed.ncbi.nlm.nih.gov/38140277/
https://www.mdpi.com/2072-6643/15/24/5018
16. What Are Adaptogenic Mushrooms? Benefits, Risks, and Types, Medically reviewed by Kim Chin, RD, Nutrition — Written by Jillian Kubala, MS, RD on March 19, 2021
https://www.healthline.com/nutrition/adaptogenic-mushrooms#safety
17. Łysakowska P, Sobota A, Wirkijowska A. Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review. Molecules. 2023 Jul 14;28(14):5393. doi: 10.3390/molecules28145393. PMID: 37513265; PMCID: PMC10384337.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10384337/
18. Magic Mushrooms, Government of Alberta, June 1, 2023
https://myhealth.alberta.ca/alberta/pages/what-are-magic-mushrooms.aspx
19. Psilocybin (Magic Mushrooms), January 2024, NIH
https://nida.nih.gov/research-topics/psilocybin-magic-mushrooms
20. What Are "Magic" Mushrooms? March 2023, Nemours® KidsHealth
https://kidshealth.org/en/parents/mushrooms.html
21. Gariboldi MB, Marras E, Ferrario N, Vivona V, Prini P, Vignati F, Perletti G. Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer. Int J Mol Sci. 2023 Jun 14;24(12):10120. doi: 10.3390/ijms241210120. PMID: 37373268; PMCID: PMC10299416.
https://pubmed.ncbi.nlm.nih.gov/37373268/
22. Chang S, Buswell J. Medicinal Mushrooms: Past, Present and Future. Adv Biochem Eng Biotechnol. 2023;184:1-27. doi: 10.1007/10_2021_197. PMID: 35220455.
https://pubmed.ncbi.nlm.nih.gov/35220455/
23. Hetland G, Johnson E, Bernardshaw SV, Grinde B. Can medicinal mushrooms have prophylactic or therapeutic effect against COVID-19 and its pneumonic superinfection and complicating inflammation? Scand J Immunol. 2021 Jan;93(1):e12937. doi: 10.1111/sji.12937. Epub 2020 Jul 29. PMID: 32657436; PMCID: PMC7404338.
https://pubmed.ncbi.nlm.nih.gov/32657436/
24. Sharma D, Singh VP, Singh NK. A Review on Phytochemistry and Pharmacology of Medicinal as well as Poisonous Mushrooms. Mini Rev Med Chem. 2018;18(13):1095-1109. doi: 10.2174/1389557517666170927144119. PMID: 28971768.
https://pubmed.ncbi.nlm.nih.gov/28971768/
25. Islam T, Ganesan K, Xu B. New Insight into Mycochemical Profiles and Antioxidant Potential of Edible and Medicinal Mushrooms: A Review. Int J Med Mushrooms. 2019;21(3):237-251. doi: 10.1615/IntJMedMushrooms.2019030079. PMID: 31002608.
https://pubmed.ncbi.nlm.nih.gov/31002608/
26. Lo HC. Bioactive Components and Possible Activities of Medicinal Mushrooms in Alleviating the Pathogenesis of Nonalcoholic Fatty Liver Disease (Review). Int J Med Mushrooms. 2021;23(3):29-41. doi: 10.1615/IntJMedMushrooms.2021037945. PMID: 33822497.
https://pubmed.ncbi.nlm.nih.gov/33822497/
27. Can You Eat Mushrooms During Pregnancy? Medically reviewed by Lisa Hodgson, RDN, CDN, CDCES, FADCES, Nutrition — Written by Amber Charles Alexis, MSPH, RDN on November 3, 2021, Healthline Media LLC
https://www.healthline.com/nutrition/can-pregnant-women-eat-mushrooms#nutrition
28. Medicinal Mushrooms Before, During, and After Pregnancy - Safety, and What Works Updated: Sep 5, 2023, Anna Sitkoff
https://www.drannasitkoff.com/post/mushroom-safety-effectiveness-pregnancy
29. Mushrooms - A Pregnancy Superfood April 15, 2024, Cincinnati Birth Center
https://www.cincinnatibirthcenter.com/blog/mushrooms-a-pregnancy-superfood
30. Sun L, Niu Z. A mushroom diet reduced the risk of pregnancy-induced hypertension and macrosomia: a randomized clinical trial. Food Nutr Res. 2020 Jun 8;64. doi: 10.29219/fnr.v64.4451. PMID: 32577117; PMCID: PMC7286351.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7286351/
31. Remedia Homeopathy - homeopathic remedies manufactory
https://remedia-homeopathy.com/about-us/
32. Ganoderma lucidum, Remedia Homeopathy
https://remedia-homeopathy.com/shop/ganoderma-lucidum/a9051134
33. Resurrection of the Vital Force: Blockages to Healing in Homeopathy By Dr Paul Anderson Theriault, BSc, ND, VNMI
https://www.lulu.com/shop/dr-paul-anderson-theriault-bsc-nd-vnmi/resurrection-of-the-vital-force-blockages-to-healing-in-homeopathy/paperback/product-1kkk77r4.html?page=1&pageSize=4
34. Arul V, Kandasamy R, SP M. Antioxidant and cytotoxic potential of potentized preparation of Cordyceps sinensis in vitro in cancer cell lines. Indian J Res Homoeopathy 2023;17. doi: 10.53945/2320-7094.1131
https://www.ijrh.org/journal/vol17/iss1/2/
35. Medicinal Mushrooms and their history of therapeutic uses for emotional and physical wellbeing in children and adults 30 Oct 2024 5:00pm to 6:30pm Conferences, CPD Resource, Education, Latest News, Webinars
https://www.facultyofhomeopathy.org/events/medicinal-mushrooms-their-history-of-therapeutic-uses
36. Gøtzsche PC. Our prescription drugs kill us in large numbers. Pol Arch Med Wewn. 2014;124(11):628-34. doi: 10.20452/pamw.2503. Epub 2014 Oct 30. PMID: 25355584.
https://pubmed.ncbi.nlm.nih.gov/25355584/
37. Peter C Gøtzsche: Prescription drugs are the third leading cause of death June 16, 2016
https://blogs.bmj.com/bmj/2016/06/16/peter-c-gotzsche-prescription-drugs-are-the-third-leading-cause-of-death/
38. Prescription Drugs Are the Leading Cause of Death And psychiatric drugs are the third leading cause of death By Peter C. Gøtzsche, MD - April 16, 2024
https://www.madinamerica.com/2024/04/prescription-drugs-are-the-leading-cause-of-death/
39. ΠΡΟΓΡΑΜΜΑ ΜΑΘΗΜΑΤΩΝ ΣΕΜΙΝΑΡΙΩΝ ΒΡΑΧΕΙΑΣ ΕΚΠΑΙΔΕΥΣΗΣ «ΤΡΙΠΤΟΛΕΜΟΣ» Κατεύθυνση: «Εδώδιμα Μανιτάρια: Καλλιέργεια – Αξιοποίηση». Χρηματοδοτείται από την Γενική Γραμματεία Δια Βίου Μάθησης και Νέας Γενιάς (Διεύθυνση Νέας Γενιάς)
https://www.minedu.gov.gr/publications/docs2016/250416_programms-endodima-manitaria.pdf
40. ΥΠΟΥΡΓΕΙΟ ΑΓΡΟΤΙΚΗΣ ΑΝΑΠΤΥΞΗΣ - ΜΑΝΙΤΑΡΙΑ
https://www.minagric.gr/images/stories/docs/agrotis/Aromatika_Fyta/Manitari_entypo_291211.pdf
41. Breene WM. Nutritional and Medicinal Value of Specialty Mushrooms. J Food Prot. 1990 Oct;53(10):883-894. doi: 10.4315/0362-028X-53.10.883. PMID: 31018285.
https://pubmed.ncbi.nlm.nih.gov/31018285/
42. Chang ST, Buswell JA. Mushroom nutriceuticals. World J Microbiol Biotechnol. 1996 Sep;12(5):473-6. doi: 10.1007/BF00419460. PMID: 24415377.
https://pubmed.ncbi.nlm.nih.gov/24415377/
43. Cao Y, Xu X, Liu S, Huang L, Gu J. Ganoderma: A Cancer Immunotherapy Review. Front Pharmacol. 2018 Oct 25;9:1217. doi: 10.3389/fphar.2018.01217. PMID: 30410443; PMCID: PMC6209820.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6209820/
44. 26 Ιανουαρίου 2019 | 19:12 Καλλιέργεια φαρμακευτικών μανιταριών από το ΤΕΙ Θεσσαλίας, in.gr
https://www.in.gr/2019/01/26/health/health-news/kalliergeia-farmakeytikon-manitarion-apo-tei-thessalias/
45. Ινστιτούτο Τεχνολογίας Γεωργικών Προϊόντων (I.ΤΕ.ΓΕ.Π)
https://itap.com.gr/edodimon-mykiton-2/
46. Ροηλίδη, Αθανασία, Ανίχνευση πιθανής πρεβιοτικής δράσης σε μύκητες του γένους Ganoderma, 2016,
https://estia.hua.gr/browse/17261
47. Εθνικό Μετσόβιο Πολυτεχνείο, Σχολή Χημικών Μηχανικών, Απομόνωση και αξιολόγηση πρωτεϊνικών και υδατανθρακικών συστατικών μανιταριών, Διπλωματική Εργασία, Τσαλτάκη Χρυσούλα
https://dspace.lib.ntua.gr/xmlui/bitstream/handle/123456789/43369/%CE%B4%CE%B9%CF%80%CE%BB%CF%89%CE%BC%CE%B1%CF%84%CE%B9%CE%BA%CE%AE%20%CE%B5%CF%81%CE%B3%CE%B1%CF%83%CE%AF%CE%B1%20-%20%CE%A4%CF%83%CE%B1%CE%BB%CF%84%CE%AC%CE%BA%CE%B7%20%CE%A7%CF%81%CF%85%CF%83%CE%BF%CF%8D%CE%BB%CE%B1.pdf?sequence=1&isAllowed=y
48. ΑΤΕΙ Καλαμάτας, Τμήμα ΤΕΓΕΠ, Πτυχιακή Εργασία, Φαρμακευτικές ιδιότητες βασιδιομυκήτων και ασκομυκήτων, Δημητριάδου Ελένη,
http://nestor.teipel.gr/xmlui/bitstream/handle/123456789/14673/STEG_TEGEP_00495_Medium.pdf?sequence=1
49. Πανεπιστήμιο Αιγαίου, Τμήμα Επιστήμης Τροφίμων και Διατροφής, Πτυχιακή Εργασία, Ο ρόλος της διατροφής στην πρόληψη του καρκίνου, Καρυωτάκη Στυλιανή,
https://hellanicus.lib.aegean.gr/bitstream/handle/11610/18640/%CE%9A%CE%B1%CF%81%CF%85%CF%89%CF%84%CE%AC%CE%BA%CE%B7%20%CE%A3%CF%84%CE%AD%CE%BB%CE%BB%CE%B1-%CE%A0%CF%84%CF%85%CF%87%CE%B1%CE%BA%CE%AE.pdf?sequence=1&isAllowed=y
50. Χαροκόπειο Πανεπιστήμιο, Ανίχνευση πιθανής πρεβιοτικής δράσης σε βασιδιομύκητες. Πτυχιακή εργασία, Σεκκίδου, Μικαέλα
https://www.openarchives.gr/aggregator-openarchives/edm/estia/000015-15662/view
51. Γεωπονικό Πανεπιστήμιο Αθηνών, Μεταπτυχιακή εργασία, Μελέτη της βιοδραστικότητας εκχυλισμάτων μυκηλίου και καρποσωμάτων μυκήτων του γένους Ganoderma, Ευσταθιάδου Ευδοξία
https://www.openarchives.gr/aggregator-openarchives/edm/aua/000039-10329_6463
52. ΑΤΕΙ Καλαμάτας, Τμήμα Θερμοκηπειακής Καλλιέργειας και Ανθοκομίας, Πτυχιακή Εργασία, Φαρμακευτικά μανιτάρια ως διαιτητικά συμπληρώματα διατροφής, Μαργαρίτα Μαρδίτσα
http://nestor.teipel.gr/xmlui/bitstream/handle/123456789/13599/STEG_THEKA_00515_Medium.pdf?sequence=1
53. Πανεπιστήμιο Θεσσαλίας Τμήμα Ιατρικής Μεταπτυχιακό Πρόγραμμα Σπουδών “Εφαρμοσμένη Δημόσια Υγεία και Περιβαλλοντική Υγιεινή: Ποιότητα- Ασφάλεια Τροφίμων & Υδάτων, Δημόσια Υγεία”, Διπλωματική Εργασία “ H Βιολογική δραστικότητα του βασιδιομύκητα Ganoderma lucidum και η συμβολή του στην προαγωγή της υγείας.” Χονδρού Αικατερίνη του Ιωάννη, 2015
https://ir.lib.uth.gr/xmlui/bitstream/handle/11615/44704/13655.pdf?sequence=1&isAllowed=y
54. ΤΜΗΜΑ ΕΠΙΣΤΗΜΗΣ ΚΑΙ ΤΕΧΝΟΛΟΓΙΑΣ ΤΡΟΦΙΜΩΝ ΠΑΝΕΠΙΣΤΗΜΙΟ ΔΥΤΙΚΗΣ ΑΤΤΙΚΗΣ, ΠΤΥΧΙΑΚΗ ΕΡΓΑΣΙΑ, ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΙΔΙΟΤΗΤΕΣ ΜΑΝΙΤΑΡΙΩΝ ΚΑΙ ΟΙ ΒΙΟΔΡΑΣΤΙΚΕΣ ΤΟΥΣ ΟΥΣΙΕΣ, Μιχοπούλου Αγγελική (Α.Μ 71614537), Ψυχογιού Μαρία (Α.Μ 71614411) Επιβλέπουσα καθηγήτρια : Στεφάνου Βαλεντίνα Αθήνα, 2021
https://polynoe.lib.uniwa.gr/xmlui/bitstream/handle/11400/1361/Michopoulou_71614537.pdf.pdf?sequence=1&isAllowed=y
55. Ταβουλτσίδη, Αικατερίνη Αγγελική, 2015, Επεξεργασία εδώδιμων μανιταριών βασιδιομυκήτων και ασκομυκήτων, Προπτυχιακή/Διπλωματική εργασία, ΤΕΙ Πελοποννησου, Τμήμα Τεχνολογίας Γεωργικών Προϊόντων (ΤΕ.ΓΕ.Π.)
http://nestor.teipel.gr/xmlui/handle/123456789/14537?show=full
56. Πάππα, Στυλιανή (2006) Τα είδη μανιταριών και η παραγωγή, αξιοποίηση και διατροφική τους αξία. BSc thesis, ΤΕΙ Δυτικής Μακεδονίας. Σχολή Τεχν.Γεωπονίας και Τεχν.Τροφίμων και Διατροφής > Τμήμα Εμπορίας και Ποιοτικού Ελέγχου Αγροτικών Προϊόντων (Φλώρινα)
https://anaktisis.uowm.gr/626/
57. Παναγιώτου, Αλεξάνδρα, Φώτιος, Επίδραση του εντερικού μικροβιόκοσμου στον οστικό μεταβολισμό, 2019,
https://estia.hua.gr/browse/21441
58. Extra Virgin Olive Oil Market Research Report Information By Category (Organic and Conventional), By Packaging (Bottles & Jars, Cans, and Others), By Distribution Channel (Store-Based, and Non-Store-Based) And By Region (North America, Europe, Asia-Pacific, And Rest Of The World) –Market Forecast Till 2032
https://www.marketresearchfuture.com/reports/extra-virgin-olive-oil-market-4124
59. Panda SK, Luyten W. Medicinal mushrooms: Clinical perspective and challenges. Drug Discov Today. 2022 Feb;27(2):636-651. doi: 10.1016/j.drudis.2021.11.017. Epub 2021 Nov 22. PMID: 34823005.
https://pubmed.ncbi.nlm.nih.gov/34823005/
60. Motta F, Gershwin ME, Selmi C. Mushrooms and immunity. J Autoimmun. 2021 Feb;117:102576. doi: 10.1016/j.jaut.2020.102576. Epub 2020 Dec 1. PMID: 33276307.
https://pubmed.ncbi.nlm.nih.gov/33276307/
61. Jeitler M, Michalsen A, Frings D, Hübner M, Fischer M, Koppold-Liebscher DA, Murthy V, Kessler CS. Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review. Front Pharmacol. 2020 Nov 11;11:580656. doi: 10.3389/fphar.2020.580656. PMID: 33424591; PMCID: PMC7794004.
https://pubmed.ncbi.nlm.nih.gov/33424591/
62. Dan A, Swain R, Belonce S, Jacobs RJ. Therapeutic Effects of Medicinal Mushrooms on Gastric, Breast, and Colorectal Cancer: A Scoping Review. Cureus. 2023 Apr 14;15(4):e37574. doi: 10.7759/cureus.37574. PMID: 37193480; PMCID: PMC10183216.
https://pubmed.ncbi.nlm.nih.gov/37193480/
63. Phan CW, David P, Sabaratnam V. Edible and Medicinal Mushrooms: Emerging Brain Food for the Mitigation of Neurodegenerative Diseases. J Med Food. 2017 Jan;20(1):1-10. doi: 10.1089/jmf.2016.3740. PMID: 28098514.
https://pubmed.ncbi.nlm.nih.gov/28098514/
64. Zhao S, Gao Q, Rong C, Wang S, Zhao Z, Liu Y, Xu J. Immunomodulatory Effects of Edible and Medicinal Mushrooms and Their Bioactive Immunoregulatory Products. J Fungi (Basel). 2020 Nov 8;6(4):269. doi: 10.3390/jof6040269. PMID: 33171663; PMCID: PMC7712035.
https://pubmed.ncbi.nlm.nih.gov/33171663/
65. Drzewiecka, B.; Wessely-Szponder, J.; Świeca, M.; Espinal, P.; Fusté, E.; Fernández-De La Cruz, E. Bioactive Peptides and Other Immunomodulators of Mushroom Origin. Biomedicines 2024, 12, 1483.
https://www.mdpi.com/2227-9059/12/7/1483
66. Hetland G, Tangen JM, Mahmood F, Mirlashari MR, Nissen-Meyer LSH, Nentwich I, Therkelsen SP, Tjønnfjord GE, Johnson E. Antitumor, Anti-Inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifolafrondosa: A Review of Preclinical and Clinical Studies. Nutrients. 2020 May 8;12(5):1339. doi: 10.3390/nu12051339. PMID: 32397163; PMCID: PMC7285126.
https://pubmed.ncbi.nlm.nih.gov/32397163/
67. Manash Pratim Pathak, Kalyani Pathak, Riya Saikia, Urvashee Gogoi, Mohammad Zaki Ahmad, Pompy Patowary, Aparoop Das, Immunomodulatory effect of mushrooms and their bioactive compounds in cancer: A comprehensive review, Biomedicine & Pharmacotherapy, Volume 149, 2022, 112901, ISSN 0753-3322.
https://www.sciencedirect.com/science/article/pii/S0753332222002906
68. Akramiene D, Kondrotas A, Didziapetriene J, Kevelaitis E. Effects of beta-glucans on the immune system. Medicina (Kaunas). 2007;43(8):597-606. PMID: 17895634.
https://pubmed.ncbi.nlm.nih.gov/17895634/
69. Dong Y, Wang T, Zhao J, Gan B, Feng R, Miao R. Polysaccharides Derived from Mushrooms in Immune and Antitumor Activity: A Review. Int J Med Mushrooms. 2023;25(8):1-17. doi: 10.1615/IntJMedMushrooms.2023049062. PMID: 37560886.
https://pubmed.ncbi.nlm.nih.gov/37560886/
70. Vetvicka V, Vannucci L, Sima P, Richter J. Beta Glucan: Supplement or Drug? From Laboratory to Clinical Trials. Molecules. 2019 Mar 30;24(7):1251. doi: 10.3390/molecules24071251. PMID: 30935016; PMCID: PMC6479769.
https://pubmed.ncbi.nlm.nih.gov/30935016/
71. Do Mushroom Supplements Boost Immunity Against Cancer? By Susan Wagner Tuesday, October 22, 2024, Memorial Sloan Kettering Cancer Center
https://www.mskcc.org/news/do-mushroom-supplements-boost-immunity-against-cancer
72. Lull C, Wichers HJ, Savelkoul HF. Antiinflammatory and immunomodulating properties of fungal metabolites. Mediators Inflamm. 2005 Jun 9;2005(2):63-80. doi: 10.1155/MI.2005.63. PMID: 16030389; PMCID: PMC1160565.
https://pmc.ncbi.nlm.nih.gov/articles/PMC1160565/
73. Gründemann C, Reinhardt JK, Lindequist U. European medicinal mushrooms: Do they have potential for modern medicine? - An update. Phytomedicine. 2020 Jan;66:153131. doi: 10.1016/j.phymed.2019.153131. Epub 2019 Nov 2. PMID: 31790898.
https://pubmed.ncbi.nlm.nih.gov/31790898/
74. Rossi P, Difrancia R, Quagliariello V, Savino E, Tralongo P, Randazzo CL, Berretta M. B-glucans from Grifola frondosa and Ganoderma lucidum in breast cancer: an example of complementary and integrative medicine. Oncotarget. 2018 May 15;9(37):24837-24856. doi: 10.18632/oncotarget.24984. PMID: 29872510; PMCID: PMC5973856.
https://pubmed.ncbi.nlm.nih.gov/29872510/
75. Frost, Megan. “Three Popular Medicinal Mushroom Supplements: A Review of Human Clinical Trials.” (2016).
https://scholarsarchive.byu.edu/cgi/viewcontent.cgi?article=2619&context=facpub
76. Naim MJ. A review on mushrooms as a versatile therapeutic agent with emphasis on its bioactive constituents for anticancer and antioxidant potential. Explor Med. 2024;5:312–30. https://doi.org/10.37349/emed.2024.00222
https://www.explorationpub.com/Journals/em/Article/1001222
77. Gafforov Y, Rašeta M, Rapior S, Yarasheva M, Wang X, Zhou L, Wan-Mohtar WAAQI, Zafar M, Lim YW, Wang M, Abdullaev B, Bussmann RW, Zengin G, Chen J. Macrofungi as Medicinal Resources in Uzbekistan: Biodiversity, Ethnomycology, and Ethnomedicinal Practices. J Fungi (Basel). 2023 Sep 13;9(9):922. doi: 10.3390/jof9090922. PMID: 37755030; PMCID: PMC10532728.
https://pubmed.ncbi.nlm.nih.gov/37755030/
78. Shamim MZ, Mishra AK, Kausar T, Mahanta S, Sarma B, Kumar V, Mishra PK, Panda J, Baek KH, Mohanta YK. Exploring Edible Mushrooms for Diabetes: Unveiling Their Role in Prevention and Treatment. Molecules. 2023 Mar 21;28(6):2837. doi: 10.3390/molecules28062837. PMID: 36985818; PMCID: PMC10058372.
https://pubmed.ncbi.nlm.nih.gov/36985818/
79. Tamrakar S, Tran HB, Nishida M, Kaifuchi S, Suhara H, Doi K, Fukami K, Parajuli GP, Shimizu K. Antioxidative activities of 62 wild mushrooms from Nepal and the phenolic profile of some selected species. J Nat Med. 2016 Oct;70(4):769-79. doi: 10.1007/s11418-016-1013-1. Epub 2016 Jun 4. PMID: 27262299.
https://pubmed.ncbi.nlm.nih.gov/27262299/
80. Rubel R, Santa HSD, Dos Santos LF, Fernandes LC, Figueiredo BC, Soccol CR. Immunomodulatory and Antitumoral Properties of Ganoderma lucidum and Agaricus brasiliensis (Agaricomycetes) Medicinal Mushrooms. Int J Med Mushrooms. 2018;20(4):393-403. doi: 10.1615/IntJMedMushrooms.2018025979. PMID: 29953399.
https://pubmed.ncbi.nlm.nih.gov/29953399/
81. Kerezoudi EN, Mitsou EK, Gioti K, Terzi E, Avgousti I, Panagiotou A, Koutrotsios G, Zervakis GI, Mountzouris KC, Tenta R, Kyriacou A. Fermentation of Pleurotus ostreatus and Ganoderma lucidum mushrooms and their extracts by the gut microbiota of healthy and osteopenic women: potential prebiotic effect and impact of mushroom fermentation products on human osteoblasts. Food Funct. 2021 Mar 1;12(4):1529-1546. doi: 10.1039/d0fo02581j. PMID: 33521800.
https://pubmed.ncbi.nlm.nih.gov/33521800/
82. Mitsou EK, Saxami G, Stamoulou E, Kerezoudi E, Terzi E, Koutrotsios G, Bekiaris G, Zervakis GI, Mountzouris KC, Pletsa V, Kyriacou A. Effects of Rich in Β-Glucans Edible Mushrooms on Aging Gut Microbiota Characteristics: An In Vitro Study. Molecules. 2020 Jun 18;25(12):2806. doi: 10.3390/molecules25122806. PMID: 32570735; PMCID: PMC7355846.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7355846/
83. Health benefits of turkey tail mushrooms, Medically reviewed by Jerlyn Jones, MS MPA RDN LD CLT, Nutrition — Written by Jennifer Berry — Updated on August 6, 2024
https://www.medicalnewstoday.com/articles/turkey-tail-mushroom
84. Rathee, Sushila et al. “Mushrooms as therapeutic agents.” Revista Brasileira De Farmacognosia-brazilian Journal of Pharmacognosy 22 (2012): 459-474.
https://www.semanticscholar.org/paper/Mushrooms-as-therapeutic-agents-Rathee-Rathee/1b648a5608279ef1c8c45c8b334b64a3d67f5131
85. Zięba P, Sękara A, Sułkowska-Ziaja K, Muszyńska B. Culinary and Medicinal Mushrooms: Insight into Growing Technologies. Acta Mycologica. 2020;55(2):1. doi:10.5586/am.5526.
https://www.journalssystem.com/amy/Culinary-and-Medicinal-Mushrooms-Insight-into-Growing-Technologies,159745,0,2.html#ungrouped
86. Carsten Gründemann, Jakob K. Reinhardt, Ulrike Lindequist, European medicinal mushrooms: Do they have potential for modern medicine? – An update, Phytomedicine, Volume 66, 2020, 153131, ISSN 0944-7113, https://doi.org/10.1016/j.phymed.2019.153131.
https://www.sciencedirect.com/science/article/abs/pii/S0944711319303848
87. International Journal of Medicinal Mushrooms Editor-in-Chief: Solomon P. Wasser, BEGELL HOUSE Inc
https://www.begellhouse.com/journals/medicinal-mushrooms.html
88. Jeitler M, Michalsen A, Frings D, Hübner M, Fischer M, Koppold-Liebscher DA, Murthy V and Kessler CS (2020) Significance of Medicinal Mushrooms in Integrative Oncology: A Narrative Review. Front. Pharmacol. 11:580656. doi: 10.3389/fphar.2020.580656
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.580656/full
89. Rahi, Deepak K., Malik, Deepika, Diversity of Mushrooms and Their Metabolites of Nutraceutical and Therapeutic Significance, Journal of Mycology, 2016, 7654123, 18 pages, 2016. https://doi.org/10.1155/2016/7654123
https://onlinelibrary.wiley.com/doi/10.1155/2016/7654123
90. Slomski A. Trials Test Mushrooms and Herbs as Anti–COVID-19 Agents. JAMA. 2021;326(20):1997–1999. doi:10.1001/jama.2021.19388
https://jamanetwork.com/journals/jama/fullarticle/2786023
91. Exploring the Uses of the Top Medicinal Mushrooms, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Tarikh Input: 22/02/2023 | Kemaskini: 04/04/2023 | aslamiah
https://sgs.upm.edu.my/artikel/exploring_the_uses_of_the_top_medicinal_mushrooms-71534
92. Fokunang, Estella & Annih, Mbong & Abongwa, Lem & Bih, Manju & Vanessa Edwige, Tchadji & Fonmboh, Dobgima & Fokunang, Charles. (2022). Medicinal Mushroom of Potential Pharmaceutical Toxic Importance: Contribution in Phytotherapy. 10.5772/intechopen.103845.
https://www.intechopen.com/chapters/81313
93. Mohammad A Rahman, T Rahman, M Rahman, M Arif. (2022). Usage of Mushrooms in Culinary and Medicinal Purposes. Biomedical Research and Clinical Reviews. 6(1); DOI: 10.31579/2692-9406/087
https://www.auctoresonline.org/article/usage-of-mushrooms-in-culinary-and-medicinal-purposes
94. Shahar O, Pereman I, Khamisie H, Ezov N, Danay O, Khattib A, Schweitzer R, Khatib S, Mahajna J. Compounds originating from the edible mushroom Auricularia auricula-judae inhibit tropomyosin receptor kinase B activity. Heliyon. 2023 Feb 16;9(3):e13756. doi: 10.1016/j.heliyon.2023.e13756. PMID: 36895384; PMCID: PMC9988514.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9988514/
95. Global Functional Mushroom Market Size Likely to Grow at a CAGR of 11.5% By 2033 Released Date: May 4, 2024 | Author Name: Katelin Kharrati | Location: Sandy, USA
https://www.custommarketinsights.com/press-releases/functional-mushroom-market-size/
96. Medicinal Mushroom Market Size, Share, Growth, and Industry Analysis, By Type (Reishi Mushroom, Chaga Mushroom, Lion’s Mane Mushrooms, Cordyceps, & Others), By Application (Household, Commercial), Regional Insights, and Forecast To 2032 Last Updated: 30 December 2024 Base Year: 2024 Historical Data: 2020-2023 No of Pages: 105
https://www.businessresearchinsights.com/market-reports/medicinal-mushroom-market-113833
97. Cordyceps Is a Killer Fungi With Potential Health Benefits, March 10, 2023, Cleveland Clinic
https://health.clevelandclinic.org/cordyceps-benefits
98. Blagodatski A., Yatsunskaya M., Mikhailova V., Tiasto V., Kagansky A., Katanaev V. L. Medicinal mushrooms as an attractive new source of natural compounds for future cancer therapy. Oncotarget. 2018; 9: 29259-29274.
https://www.oncotarget.com/article/25660/text/
99. HURIEZ C. Indications actuelles de la mycothérapie [Current indications of mycotherapy]. Paris Med. 1945 Nov 30;35:374-80. French. PMID: 21021559.
https://pubmed.ncbi.nlm.nih.gov/21021559/
100. DIOT. Premiers essais de mycothérapie dans les affections pyogènes et leurs résultats [First trials of mycotherapy in pyogenic conditions and their results]. Maroc Med. 1946 Feb-Mar;25(258):10-2. French. PMID: 20993868.
https://pubmed.ncbi.nlm.nih.gov/20993868/
101. CHABROL E. La mycothérapie dans les cirrhoses du foie [Mycotherapy in liver cirrhosis]. Presse Therm Clim. 1949 Jan-Feb;86(1-2):1-5. French. PMID: 18115812.
https://pubmed.ncbi.nlm.nih.gov/18115812/
102. KOURILSKY R. La mycothérapie dans la tuberculose pulmonaire chronique [Mycotherapy in chronic pulmonary tuberculosis]. Laval Med. 1949 Dec;14(10):1319-40. French. PMID: 15408327.
https://pubmed.ncbi.nlm.nih.gov/15408327/
103. Guggenheim AG, Wright KM, Zwickey HL. Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology. Integr Med (Encinitas). 2014 Feb;13(1):32-44. PMID: 26770080; PMCID: PMC4684115.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4684115/
104. Mau JL, Lin HC, Chen CC. Antioxidant properties of several medicinal mushrooms. J Agric Food Chem. 2002 Oct 9;50(21):6072-7. doi: 10.1021/jf0201273. PMID: 12358482.
https://pubmed.ncbi.nlm.nih.gov/12358482/
105. Geng, Ping, Siu, Ka-Chai, Wang, Zhaomei, Wu, Jian-Yong, Antifatigue Functions and Mechanisms of Edible and Medicinal Mushrooms, BioMed Research International, 2017, 9648496, 16 pages, 2017. https://doi.org/10.1155/2017/9648496
https://onlinelibrary.wiley.com/doi/10.1155/2017/9648496
106. Podkowa, A., Kryczyk-Poprawa, A., Opoka, W. et al. Culinary–medicinal mushrooms: a review of organic compounds and bioelements with antioxidant activity. Eur Food Res Technol 247, 513–533 (2021). https://doi.org/10.1007/s00217-020-03646-1
https://link.springer.com/article/10.1007/s00217-020-03646-1
107. Merdivan, S., Lindequist, U. (2017). Medicinal Mushrooms with Antiallergic Activities. In: Agrawal, D., Tsay, HS., Shyur, LF., Wu, YC., Wang, SY. (eds) Medicinal Plants and Fungi: Recent Advances in Research and Development. Medicinal and Aromatic Plants of the World, vol 4. Springer, Singapore. https://doi.org/10.1007/978-981-10-5978-0_4
https://link.springer.com/chapter/10.1007/978-981-10-5978-0_4
108. Alvandi, H., Ansari, E. ., Kianirad, S. ., Hatamian-Zarmi, A., Mokhtari Hosseini, Z. B., & Ebrahimi-Hosseinzadeh, B. (2022). Medicinal mushrooms as potential therapeutic agents in the treatment of diabetes mellitus: a review with focusing on in vivo and clinical studies. Italian Journal of Mycology, 51(1), 75–96. https://doi.org/10.6092/issn.2531-7342/15023
https://italianmycology.unibo.it/article/view/15023
109. De Silva, D.D., Rapior, S., Hyde, K.D. et al. Medicinal mushrooms in prevention and control of diabetes mellitus. Fungal Diversity 56, 1–29 (2012). https://doi.org/10.1007/s13225-012-0187-4
https://link.springer.com/article/10.1007/s13225-012-0187-4
110. Ebru Deveci, Fatih Çayan, Gülsen Tel-Çayan, Mehmet Emin Duru, Inhibitory activities of medicinal mushrooms on α-amylase and α-glucosidase-enzymes related to type 2 diabetes, South African Journal of Botany, Volume 137, 2021, Pages 19-23, ISSN 0254-6299, https://doi.org/10.1016/j.sajb.2020.09.039.
https://www.sciencedirect.com/science/article/pii/S025462992031111X
111. Al Qutaibi, Mohammed, Kagne, Suresh R., Unearthing Nature’s Pharmacy: Exploring the Antimicrobial Potency of Mushrooms, Journal of Food Processing and Preservation, 2024, 8331974, 14 pages, 2024. https://doi.org/10.1155/2024/8331974
https://onlinelibrary.wiley.com/doi/full/10.1155/2024/8331974
112. Ashaimaa Y. Moussa, Shaimaa Fayez, Hang Xiao, Baojun Xu, New insights into antimicrobial and antibiofilm effects of edible mushrooms, Food Research International, Volume 162, Part A, 2022, 111982, ISSN 0963-9969, https://doi.org/10.1016/j.foodres.2022.111982.
https://www.sciencedirect.com/science/article/abs/pii/S0963996922010407
113. The Antimicrobial Benefits of Mushrooms, U.S. department of agriculture,
https://tellus.ars.usda.gov/stories/articles/antimicrobial-benefits-mushrooms
114. Soares AA, de Sá-Nakanishi AB, Bracht A, da Costa SM, Koehnlein EA, de Souza CG, Peralta RM. Hepatoprotective effects of mushrooms. Molecules. 2013 Jul 1;18(7):7609-30. doi: 10.3390/molecules18077609. PMID: 23884116; PMCID: PMC6270077.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6270077/
115. Yadav SK, Ir R, Jeewon R, Doble M, Hyde KD, Kaliappan I, Jeyaraman R, Reddi RN, Krishnan J, Li M, Durairajan SSK. A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders. Planta Med. 2020 Nov;86(16):1161-1175. doi: 10.1055/a-1177-4834. Epub 2020 Jul 14. PMID: 32663897.
https://www.thieme-connect.com/products/ejournals/pdf/10.1055/a-1177-4834.pdf
116. McCain, P. et al. (2023). Cognitive Enhancing Effects of Medicinal Mushrooms: A Potential Neuroprotective Implication in Dementias. In: Agrawal, D.C., Dhanasekaran, M. (eds) Mushrooms with Therapeutic Potentials. Springer, Singapore. https://doi.org/10.1007/978-981-19-9550-7_8
https://link.springer.com/chapter/10.1007/978-981-19-9550-7_8#citeas
117. Vikineswary Sabaratnam, Chia-Wei Phan, Chapter 10 - Neuroactive Components of Culinary and Medicinal Mushrooms With Potential to Mitigate Age-Related Neurodegenerative Diseases, Editor(s): Goutam Brahmachari, In Natural Product Drug Discovery, Discovery and Development of Neuroprotective Agents from Natural Products, Elsevier, 2018, Pages 401-413, ISBN 9780128095935, https://doi.org/10.1016/B978-0-12-809593-5.00010-0.
https://www.sciencedirect.com/science/article/abs/pii/B9780128095935000100
118. Mushrooms with Therapeutic Potentials Recent Advances in Research and Development, Book, 2023, Springer Nature
https://link.springer.com/book/10.1007/978-981-19-9550-7
119. Medicinal Mushrooms Help Fight Cognitive Decline & Protect Your Brain, Food for the Brain, Sophie Barret – Hifas da Terra & Patrick Holford
https://foodforthebrain.org/medicinal-mushrooms-help-fight-cognitive-decline-protect-your-brain/
120. Badalyan, Susanna & Rapior, Sylvie. (2020). AGARICOMYCETES MEDICINAL MUSHROOMS WITH POTENTIAL NEUROPROTECTIVE ACTIVITY GROWING IN ARMENIA. 54. 196-203. 10.46991/PYSU:B/2020.54.3.196.
https://hal.umontpellier.fr/hal-03090953v1/document
121. Srivastava, Anuradha & Attri, BL & Sharma, VP. (2020). Status report on mushroom based nutraceutical products in the market. Mushroom Research. 28. 10.36036/MR.28.2.2020.97575.
https://www.researchgate.net/publication/341518522_Status_report_on_mushroom_based_nutraceutical_products_in_the_market
122. Niego AG, Rapior S, Thongklang N, Raspé O, Jaidee W, Lumyong S, Hyde KD. Macrofungi as a Nutraceutical Source: Promising Bioactive Compounds and Market Value. J Fungi (Basel). 2021 May 19;7(5):397. doi: 10.3390/jof7050397. PMID: 34069721; PMCID: PMC8161071.
https://pubmed.ncbi.nlm.nih.gov/34069721
123. Book, Mushrooms Nutraceuticals and Functional Foods, Deepu Pandita, Anu Pandita, Taylor & Francis
https://www.taylorfrancis.com/books/edit/10.1201/9781003322238/mushrooms-deepu-pandita-anu-pandita
124. Khatun, Selima et al. “Research on Mushroom as a Potential Source of Nutraceuticals: A Review on Indian Perspective.” American Journal of Experimental Agriculture 2 (2012): 47-73.
https://britishagroproducts.com/pdf/Mushroom%20as%20a%20Potential%20source%20of%20Nutraceuticals.pdf
125. Mankar, Someshwar & Thombare, Shailesh & Todmal, Tejas & Waghe, Raj & Borde, Akash. (2022). Medicinal Mushroom: An Ancient culture towards new lifestyle. Research Journal of Pharmacognosy and Phytochemistry. 50-54. 10.52711/0975-4385.2022.00011.
https://rjpponline.org/HTML_Papers/Research%20Journal%20of%20Pharmacognosy%20and%20Phytochemistry__PID__2022-14-1-11.html
126. Gargano, M. L., van Griensven, L. J. L. D., Isikhuemhen, O. S., Lindequist, U., Venturella, G., Wasser, S. P., & Zervakis, G. I. (2017). Medicinal mushrooms: Valuable biological resources of high exploitation potential. Plant Biosystems - An International Journal Dealing with All Aspects of Plant Biology, 151(3), 548–565. https://doi.org/10.1080/11263504.2017.1301590
https://www.tandfonline.com/doi/abs/10.1080/11263504.2017.1301590
127. Chapter Medicinal mushroom nutraceutical commercialization: Two sides of a coin, Jovana VundukORCID Icon, Daniel Tura, Alona Yu. BiketovaORCID Icon, Book Wild Mushrooms, Taylor & Francis
https://www.taylorfrancis.com/chapters/edit/10.1201/9781003152583-5/medicinal-mushroom-nutraceutical-commercialization-two-sides-coin-jovana-vunduk-daniel-tura-alona-yu-biketova
128. CHABROL E. La mycotherapie dans les affections du foie et des voies biliaires [Mycotherapy in affections of the liver and bile ducts]. Rev Prat. 1952 Apr 1;2(10):613-4. Undetermined Language. PMID: 13028009.
https://pubmed.ncbi.nlm.nih.gov/13028009/
129. integrative medicine, National Cancer Institute
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/integrative-medicine
130. The University of Arizona, Episode #18 A Kingdom of Their Own - How Fungi Shape Our World with Merlin Sheldrake
https://awcim.arizona.edu/podcast/episode18_sheldrake.html
131. The Magic of Medicinal Mushrooms, The National Centre for Integrative Medicine, Dr Elizabeth Thompson
https://ncim.org.uk/the-magic-of-medicinal-mushrooms
132. Mycotherapy for women’s health 07 Jun 2024, PhD. Catalina Fernandez de Ana Portela, Integrative & Personalised Medicine
https://ipmcongress.com/2024-workshop-programme/mycotherapy-womens-health-discover-medicinal-mushrooms-support-different-phases-womanhood-hormonal-metabolic-challenges-emotional-balance-vaginal-health
133. Mycotherapy, Onkoklinika, Russia
https://onco.rehab/en/fields/mycotherapy/
134. Clinical Experience About the Use of Complementary and Alternative Medicine in Spain, Dr. Maria Assuncion Peiré Catalano Institute of Health, Barcelona, Spain
https://www.europeanreview.org/wp/wp-content/uploads/9457-9466.pdf
135. Children's Hospital at Montefiore, Bronx, NY.
https://www.cham.org/HealthwiseArticle.aspx?id=ncicdr0000778943
136. Memorial Sloan Kettering Cancer Center, Thursday, February 9, 2023, Reishi Mushroom
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/reishi-mushroom
137. Mushrooms and Cancer Nov 11, British Society for Integrative Oncology
https://www.bsio.org.uk/blog/mushrooms-and-cancer
138. Mycomedicinals (Mushrooms) for Cancer, Srivani Sridhar, MD (2014, updated 2020).
https://www.va.gov/WHOLEHEALTHLIBRARY/tools/mycomedicinals-mushrooms-for-cancer.asp
139. 2008 A Guide to Integrative Oncology University of Washington | Bastyr University
https://depts.washington.edu/psworks/integrative/clinicians/act/mushroom_extracts.shtml
140. Chugh RM, Mittal P, Mp N, Arora T, Bhattacharya T, Chopra H, Cavalu S, Gautam RK. Fungal Mushrooms: A Natural Compound With Therapeutic Applications. Front Pharmacol. 2022 Jul 13;13:925387. doi: 10.3389/fphar.2022.925387. PMID: 35910346; PMCID: PMC9328747.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9328747/
141. Adaptogenic or Medicinal Mushrooms, Published April 20, 2009, M. Saljoughian, PharmD, PhD Alta Bates Summit Medical Center Department of Pharmacy Services Berkeley, California,
https://www.uspharmacist.com/article/adaptogenic-or-medicinal-mushrooms
142. Adaptogens, Cleveland Clinic, Last reviewed on 02/10/2022.
https://my.clevelandclinic.org/health/drugs/22361-adaptogens
143. What are adaptogens and should you be taking them? February 16, 2022 By uclahealth,
https://www.uclahealth.org/news/article/what-are-adaptogens-and-should-you-be-taking-them
144. Medicinal Mushrooms and their history of therapeutic uses, Sophie Barrett, Medical Herbalist, Naturopath, Faculty of Homeopathy
https://www.facultyofhomeopathy.org/events/medicinal-mushrooms-their-history-of-therapeutic-uses
145. Bocharova OA. Adaptogeny kak sredstva profilakticheskoĭ onkologii [Adaptogens as agents for prophylactic oncology]. Vestn Ross Akad Med Nauk. 1999;(5):49-53. Russian. PMID: 10394302.
https://pubmed.ncbi.nlm.nih.gov/10394302/
146. Panossian A, Wikman G, Kaur P, Asea A. Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones. Phytomedicine. 2009 Jun;16(6-7):617-22. doi: 10.1016/j.phymed.2008.12.003. Epub 2009 Feb 1. PMID: 19188053.
https://pubmed.ncbi.nlm.nih.gov/19188053
147. Khanum F, Bawa AS, Singh B. Rhodiola rosea: A Versatile Adaptogen. Compr Rev Food Sci Food Saf. 2005 Jul;4(3):55-62. doi: 10.1111/j.1541-4337.2005.tb00073.x. PMID: 33430554.
https://pubmed.ncbi.nlm.nih.gov/33430554/
148. Blyumin-Karasik M, Colon J, Nguyen S, Rosen J. Laser and Skin-Care Synergy: A Post-Laser Application of Novel Adaptogenic Moisturizing Serum for Improving Healing and Cosmesis on the Face. J Cosmet Dermatol. 2024 Nov 6. doi: 10.1111/jocd.16668. Epub ahead of print. PMID: 39503217.
https://pubmed.ncbi.nlm.nih.gov/39503217/
149. Liu XX, Chen CY, Li L, Guo MM, He YF, Meng H, Dong YM, Xiao PG, Yi F. Bibliometric Study of Adaptogens in Dermatology: Pharmacophylogeny, Phytochemistry, and Pharmacological Mechanisms. Drug Des Devel Ther. 2023 Feb 6;17:341-361. doi: 10.2147/DDDT.S395256. PMID: 36776447; PMCID: PMC9912821.
https://pubmed.ncbi.nlm.nih.gov/36776447/
150. KrishnaRaju AV, Somepalli V, Thanawala S, Shah R. Efficacy and Anti-Inflammatory Activity of Ashwagandha Sustained-Release Formulation on Depression and Anxiety Induced by Chronic Unpredictable Stress: in vivo and in vitro Studies. J Exp Pharmacol. 2023 Jul 25;15:291-305. doi: 10.2147/JEP.S407906. PMID: 37521489; PMCID: PMC10386834.
https://pubmed.ncbi.nlm.nih.gov/37521489/
151. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012 Jul;34(3):255-62. doi: 10.4103/0253-7176.106022. PMID: 23439798; PMCID: PMC3573577.
https://pubmed.ncbi.nlm.nih.gov/23439798/
152. Okoh L, Ajayi AM, Ben-Azu B, Akinluyi ET, Emokpae O, Umukoro S. D-Ribose-L-cysteine exhibits adaptogenic-like activity through inhibition of oxido-inflammatory responses and increased neuronal caspase-3 activity in mice exposed to unpredictable chronic mild stress. Mol Biol Rep. 2020 Oct;47(10):7709-7722. doi: 10.1007/s11033-020-05845-1. Epub 2020 Sep 21. PMID: 32959196.
https://pubmed.ncbi.nlm.nih.gov/32959196/
153. Wróbel-Biedrawa D, Podolak I. Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review. Molecules. 2024 Feb 15;29(4):866. doi: 10.3390/molecules29040866. PMID: 38398618; PMCID: PMC10891670.
https://pubmed.ncbi.nlm.nih.gov/38398618/
154. Panossian A. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals. Ann N Y Acad Sci. 2017 Aug;1401(1):49-64. doi: 10.1111/nyas.13399. Epub 2017 Jun 22. PMID: 28640972.
https://pubmed.ncbi.nlm.nih.gov/28640972
155. Chakraborty, Nilanjana et al. “Mushroom Polysaccharides: a Potent Immune-Modulator.” Biointerface Research in Applied Chemistry (2020): n. pag.
https://biointerfaceresearch.com/wp-content/uploads/2020/08/20695837112.89158930.pdf
156. Bhushan, Apoorva; Kulshreshtha, Mayank. The Medicinal Mushroom Agaricus bisporus: Review of Phytopharmacology and Potential Role in the Treatment of Various Diseases. Journal of Nature and Science of Medicine 1(1):p 4-9, Jan–Jun 2018. | DOI: 10.4103/JNSM.JNSM_1_18
https://journals.lww.com/jnsm/fulltext/2018/01010/the_medicinal_mushroom_agaricus_bisporus__review.3.aspx
157. Elkhateeb, Waill & Daba, Ghoson & Elnahas, Marwa & Thomas, Paul. (2019). Anticoagulant Capacities of Some Medicinal Mushrooms. Journal of Pharmaceutical Sciences. 5. 12-16.
https://www.researchgate.net/publication/336231517_Anticoagulant_Capacities_of_Some_Medicinal_Mushrooms
158. Rahul Mehta. 2020. Anti-thrombotic Attribute of Different Type of Mushrooms.Int.J.Curr.Microbiol.App.Sci. 9(8): 815-820. doi: https://doi.org/10.20546/ijcmas.2020.908.087
https://www.ijcmas.com/abstractview.php?ID=18640&vol=9-8-2020&SNo=87
159. Sabaratnam, Vikineswary & Ali, Shahjahan & Tieng, Kho & Tieng, – & Chiew-Pin, Teo & Panjavaranam, Kayathri & Tan, Yee Shin & Ling, Tau & Kek-Heng, Chua & Muniandy, Sekaran. (2013). FIBRINOLYTIC AND ANTICOAGULANT ENZYMES OF SELECTED MEDICINAL AND CULINARY MUSHROOMS.
https://www.researchgate.net/publication/264977421_FIBRINOLYTIC_AND_ANTICOAGULANT_ENZYMES_OF_SELECTED_MEDICINAL_AND_CULINARY_MUSHROOMS
160. Seon-Joo Yoon, Myeong-Ae Yu, Yu-Ryang Pyun, Jae-Kwan Hwang, Djong-Chi Chu, Lekh Raj Juneja, Paulo A.S. Mourão, The nontoxic mushroom Auricularia auricula contains a polysaccharide with anticoagulant activity mediated by antithrombin, Thrombosis Research, Volume 112, Issue 3, 2003, Pages 151-158, ISSN 0049-3848, https://doi.org/10.1016/j.thromres.2003.10.022.
https://www.sciencedirect.com/science/article/abs/pii/S0049384803005504
161. Nataraj, A.; Govindan, S.; Ramani, P.; Subbaiah, K.A.; Sathianarayanan, S.; Venkidasamy, B.; Thiruvengadam, M.; Rebezov, M.; Shariati, M.A.; Lorenzo, J.M.; et al. Antioxidant, Anti-Tumour, and Anticoagulant Activities of Polysaccharide from Calocybe indica (APK2). Antioxidants 2022, 11, 1694. https://doi.org/10.3390/antiox11091694
https://www.mdpi.com/2076-3921/11/9/1694
162. Safety of Medicinal Mushrooms in Patients With Cancer November 14, 2017, Oncology Nursing Society
https://www.ons.org/publications-research/voice/news-views/11-2017/safety-medicinal-mushrooms-patients-cancer
163. MedlinePlus, Reishi Mushroom, 08/16/2022,
https://medlineplus.gov/druginfo/natural/905.html
164. Jakopovich I. New dietary supplements from medicinal mushrooms: Dr Myko San--a registration report. Int J Med Mushrooms. 2011;13(3):307-13. doi: 10.1615/intjmedmushr.v13.i3.110. PMID: 22135883.
https://pubmed.ncbi.nlm.nih.gov/22135883/
165. Roda, Elisa, et al. "From a medicinal mushroom blend a direct anticancer effect on triple-negative breast cancer: a preclinical study on lung metastases." Molecules 25.22 (2020): 5400.
Google Scholar
166. De Luca, Fabrizio, et al. "Fighting secondary triple-negative breast cancer in cerebellum: a powerful aid from a medicinal mushrooms blend." Biomedicine & Pharmacotherapy 159 (2023): 114262.
Google Scholar
167. Abdullah, E.; Abidin, N.Z.; Abdullah, N. Cytotoxic Proteins from King Tuber Oyster Medicinal Mushroom, Pleurotus Tuber-Regium (Agaricomycetes), Sclerotium against Human MDA-MB-231 Breast Cancer Cells. Int. J. Med. Mushrooms 2022, 24, 27–40
Google Scholar
168. Wong JH, Ng TB, Chan HHL, Liu Q, Man GCW, Zhang CZ, Guan S, Ng CCW, Fang EF, Wang H, Liu F, Ye X, Rolka K, Naude R, Zhao S, Sha O, Li C, Xia L. Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials. Appl Microbiol Biotechnol. 2020 Jun;104(11):4675-4703. doi: 10.1007/s00253-020-10476-4. Epub 2020 Apr 9. PMID: 32274562.
https://pubmed.ncbi.nlm.nih.gov/32274562/
169. Cai H, Li J, Gu B, Xiao Y, Chen R, Liu X, Xie X, Cao L. Extracts of Cordyceps sinensis inhibit breast cancer cell metastasis via down-regulation of metastasis-related cytokines expression. J Ethnopharmacol. 2018 Mar 25;214:106-112. doi: 10.1016/j.jep.2017.12.012. Epub 2017 Dec 15. PMID: 29253616.
https://pubmed.ncbi.nlm.nih.gov/29253616/
170. Zhong C, Li Y, Li W, Lian S, Li Y, Wu C, Zhang K, Zhou G, Wang W, Xu H, Huang M, Katanaev V, Jia L, Lu Y. Ganoderma lucidum extract promotes tumor cell pyroptosis and inhibits metastasis in breast cancer. Food Chem Toxicol. 2023 Apr;174:113654. doi: 10.1016/j.fct.2023.113654. Epub 2023 Feb 8. PMID: 36758785.
https://pubmed.ncbi.nlm.nih.gov/36758785/
171. Martínez-Montemayor, Michelle M., et al. "Ganoderma lucidum (Reishi) inhibits cancer cell growth and expression of key molecules in inflammatory breast cancer." Nutrition and cancer 63.7 (2011): 1085-1094.
Google Scholar
172. Zhang Y, Sun D, Meng Q, Guo W, Chen Q, Zhang Y. [Corrigendum] Grifola frondosa polysaccharides induce breast cancer cell apoptosis via the mitochondrial-dependent apoptotic pathway. Int J Mol Med. 2022 Nov;50(5):136. doi: 10.3892/ijmm.2022.5192. Epub 2022 Sep 21. Erratum for: Int J Mol Med. 2017 Oct;40(4):1089-1095. doi: 10.3892/ijmm.2017.3081. PMID: 36129150; PMCID: PMC9559173.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9559173/
173. Hseu, You-Cheng, et al. "Antrodia salmonea suppresses invasion and metastasis in triple-negative breast cancer cells by reversing EMT through the NF-κB and Wnt/β-catenin signaling pathway." Food and Chemical Toxicology 124 (2019): 219-230.
https://pubmed.ncbi.nlm.nih.gov/30529123/
174. Karnofsky Performance Status Scale, Jan 19, 2023, WebMD, Buck Christensen; Buck Christensen
https://emedicine.medscape.com/article/2172510-overview?form=fpf
175. Survey Finds Brain Health is a Top Priority for Americans a woman smiling at the camera By Paula Croxson, Ph.D. Dana Foundation
https://dana.org/article/survey-finds-brain-health-is-a-top-priority-for-americans/
176. Avan A, Hachinski V, the Brain Health Learn, Act Group. Brain health: Key to health, productivity, and well-being. Alzheimer's Dement. 2022; 18: 1396–1407. https://doi.org/10.1002/alz.12478
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12478
177. World Health Organisation’s Global Health Estimates reveal dementia as a top three cause of death in Europe, Alzheimer Europe, 09/12/2020
https://www.alzheimer-europe.org/news/world-health-organisations-global-health-estimates-reveal-dementia-top-three-cause-death?language_content_entity=en
178. ReFaey K, Tripathi S, Grewal SS, Bhargav AG, Quinones DJ, Chaichana KL, Antwi SO, Cooper LT, Meyer FB, Dronca RS, Diasio RB, Quinones-Hinojosa A. Cancer Mortality Rates Increasing vs Cardiovascular Disease Mortality Decreasing in the World: Future Implications. Mayo Clin Proc Innov Qual Outcomes. 2021 Jun 8;5(3):645-653. doi: 10.1016/j.mayocpiqo.2021.05.005. PMID: 34195556; PMCID: PMC8240359.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8240359/
179. Alzheimer's Disease Facts and Figures, Alzheimer's Association
https://www.alz.org/alzheimers-dementia/facts-figures
180. Lewis JE, Poles J, Shaw DP, et al. The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. Journal of Clinical and Translational Research. 2021 Aug;7(4):575-620. PMID: 34541370; PMCID: PMC8445631.
https://europepmc.org/article/MED/34541370
181. Yiannopoulou KG, Papageorgiou SG. Current and Future Treatments in Alzheimer Disease: An Update. J Cent Nerv Syst Dis. 2020 Feb 29;12:1179573520907397. doi: 10.1177/1179573520907397. PMID: 32165850; PMCID: PMC7050025.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7050025/
182. 22 August, 2024, RightCare dementia scenario, NHS England
https://www.england.nhs.uk/long-read/rightcare-dementia-scenario/
183. Neuroscience, Brain Health and Nutrients, Clinical Education
https://www.clinicaleducation.org/brain-health/neuroscience-brain-health-and-nutrients/
184. Stamets P, Zwickey H. Medicinal Mushrooms: Ancient Remedies Meet Modern Science. Integr Med (Encinitas). 2014 Feb;13(1):46-7. PMID: 26770081; PMCID: PMC4684114.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4684114/
185. Zhang S, Zhang S, Tomata Y, et al. Mushroom Consumption and Incident Dementia in Elderly Japanese: The Ohsaki Cohort 2006 Study. Journal of the American Geriatrics Society. 2017 Jul;65(7):1462-1469. DOI: 10.1111/jgs.14812. PMID: 28295137.
https://europepmc.org/article/MED/28295137
186. Yin Z, Chen J, Zhang J, et al. Dietary Patterns Associated with Cognitive Function among the Older People in Underdeveloped Regions: Finding from the NCDFaC Study. Nutrients. 2018 Apr;10(4):E464. DOI: 10.3390/nu10040464. PMID: 29642510; PMCID: PMC5946249.
https://europepmc.org/article/MED/29642510
187. Shang X, Hodge AM, Hill E, Zhu Z, He M. Associations of Dietary Pattern and Sleep Duration with Cognitive Decline in Community-Dwelling Older Adults: A Seven-Year Follow-Up Cohort Study. J Alzheimers Dis. 2021;82(4):1559-1571. doi: 10.3233/JAD-201329. PMID: 34180411.
https://pubmed.ncbi.nlm.nih.gov/34180411/
188. Sabaratnam V, Kah-Hui W, Naidu M, Rosie David P. Neuronal health - can culinary and medicinal mushrooms help? J Tradit Complement Med. 2013 Jan;3(1):62-8. doi: 10.4103/2225-4110.106549. PMID: 24716157; PMCID: PMC3924982.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3924982/
189. Stephen McMahon, Beth Murinson, CHAPTER 25 - Therapeutic Potential of Neurotrophic Factors, Editor(s): Stephen Waxman, From Neuroscience To Neurology, Academic Press, 2005, Pages 419-431, ISBN 9780127389035, https://doi.org/10.1016/B978-012738903-5/50026-6.
https://www.sciencedirect.com/science/article/abs/pii/B9780127389035500266
190. Ganesan, Anusiya & Udayakumar, Gowthama Prabu & Yamini, N & Sivarajasekar, N. & K, Rambabu & Govindan, Bharath & Banat, Fawzi. (2021). A review of the therapeutic and biological effects of edible and wild mushrooms. Bioengineered. 12. 10.1080/21655979.2021.2001183.
https://www.researchgate.net/publication/355953195_A_review_of_the_therapeutic_and_biological_effects_of_edible_and_wild_mushrooms
191. Mushrooms magnify memory by boosting nerve growth, 10 February 2023, The University of Queensland
https://www.uq.edu.au/news/article/2023/02/mushrooms-magnify-memory-boosting-nerve-growth-0
192. Eik LF, Naidu M, David P, Wong KH, Tan YS, Sabaratnam V. Lignosus rhinocerus (Cooke) Ryvarden: A Medicinal Mushroom That Stimulates Neurite Outgrowth in PC-12 Cells. Evid Based Complement Alternat Med. 2012;2012:320308. doi: 10.1155/2012/320308. Epub 2011 Dec 6. PMID: 22203867; PMCID: PMC3235797.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3235797/
193. Khodosevich, K., Monyer, H. Signaling involved in neurite outgrowth of postnatally born subventricular zone neurons in vitro. BMC Neurosci 11, 18 (2010). https://doi.org/10.1186/1471-2202-11-18
https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-11-18
194. Miller KE and Suter DM (2018) An Integrated Cytoskeletal Model of Neurite Outgrowth. Front. Cell. Neurosci. 12:447. doi: 10.3389/fncel.2018.00447
https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2018.00447/full
195. Szućko-Kociuba I, Trzeciak-Ryczek A, Kupnicka P, Chlubek D. Neurotrophic and Neuroprotective Effects of Hericium erinaceus. Int J Mol Sci. 2023 Nov 3;24(21):15960. doi: 10.3390/ijms242115960. PMID: 37958943; PMCID: PMC10650066.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10650066/
196. Aloe L, Rocco ML, Balzamino BO, Micera A. Nerve Growth Factor: A Focus on Neuroscience and Therapy. Curr Neuropharmacol. 2015;13(3):294-303. doi: 10.2174/1570159x13666150403231920. PMID: 26411962; PMCID: PMC4812798.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4812798/
197. Capossela, L.; Gatto, A.; Ferretti, S.; Di Sarno, L.; Graglia, B.; Massese, M.; Soligo, M.; Chiaretti, A. Multifaceted Roles of Nerve Growth Factor: A Comprehensive Review with a Special Insight into Pediatric Perspectives. Biology 2024, 13, 546. https://doi.org/10.3390/biology13070546
https://www.mdpi.com/2079-7737/13/7/546
198. Zhang, Y., Chen, H., Li, R. et al. Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future. Sig Transduct Target Ther 8, 248 (2023). https://doi.org/10.1038/s41392-023-01484-7
https://www.nature.com/articles/s41392-023-01484-7
199. Murphy MP, LeVine H 3rd. Alzheimer's disease and the amyloid-beta peptide. J Alzheimers Dis. 2010;19(1):311-23. doi: 10.3233/JAD-2010-1221. PMID: 20061647; PMCID: PMC2813509.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2813509/
200. Ancient medicine could hold the key to dementia treatment, The University of Queensland
https://stories.uq.edu.au/research/2023/ancient-medicine-could-hold-key-to-dementia-treatment/index.html
201. Fear of dementia overtakes cancer for older Australians, as new study looks at lifestyle and diet options By medical reporter Sophie Scott and the Specialist Reporting Team's Brooke Wylie, Mon 25 Nov 2019, ABC News
https://www.abc.net.au/news/2019-11-26/dementia-lifestyle-exercise-diet-options-give-hint-at-prevention/11722796
202. Dementia tsunami: Alzheimer's and other dementias to triple by 2050 3 September 2015, University of Sydney
https://www.sydney.edu.au/news-opinion/news/2015/09/03/the-dementia-tsunami--alzheimer-s-disease-and-other-dementias-ex.html
203. Riley RJ, Burgener S, Buckwalter KC. Anxiety and stigma in dementia: a threat to aging in place. Nurs Clin North Am. 2014 Jun;49(2):213-31. doi: 10.1016/j.cnur.2014.02.008. PMID: 24846469; PMCID: PMC4032087.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4032087/
204. Fear of Alzheimer's disease in the French population: impact of age and proximity to the disease Cantegreil-Kallen, Inge et al. International Psychogeriatrics, Volume 24, Issue 1, 108 - 116
https://www.intpsychogeriatrics.org/article/S1041-6102(24)02120-3/fulltext
205. (2014), 2014 Alzheimer's disease facts and figures. Alzheimer's & Dementia, 10: e47-e92. https://doi.org/10.1016/j.jalz.2014.02.001
https://alz-journals.onlinelibrary.wiley.com/doi/10.1016/j.jalz.2014.02.001
206. Watson R, Sanson-Fisher R, Bryant J, Mansfield E. Dementia is the second most feared condition among Australian health service consumers: results of a cross-sectional survey. BMC Public Health. 2023 May 12;23(1):876. doi: 10.1186/s12889-023-15772-y. PMID: 37173717; PMCID: PMC10176813.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10176813/
207. Fear of diseases among people over 50 years of age: A survey, Martin Bystad, Ole Grønli, Camilla Lilleeggen & Per M. Aslaksen Last updated: 16.11.19 Published: 11.12.16, Psykologisk.no
https://psykologisk.no/sp/2016/12/e19/
208. Dementia ‘more feared than cancer’ by older patients 04 August, 2014 By The Press Association, Nursing Times
https://www.nursingtimes.net/older-peoples-nursing/dementia-more-feared-than-cancer-by-older-patients-04-08-2014/
209. Over half of people fear dementia diagnosis, 62 per cent think it means 'life is over' Friday 13 May 2016, Alzheimer's Society
https://www.alzheimers.org.uk/news/2024-11-22/over-half-people-fear-dementia-diagnosis-62-cent-think-it-means-life-over
210. The later stage of dementia, Alzheimer's Society,
https://www.alzheimers.org.uk/about-dementia/symptoms-and-diagnosis/how-dementia-progresses/later-stages-dementia
211. Phillips, J.M.; Ooi, S.L.; Pak, S.C. Health-Promoting Properties of Medicinal Mushrooms and Their Bioactive Compounds for the COVID-19 Era—An Appraisal: Do the Pro-Health Claims Measure Up? Molecules 2022, 27, 2302. https://doi.org/10.3390/molecules27072302
https://www.mdpi.com/1420-3049/27/7/2302
212. Mahmood F, Hetland G, Nentwich I, et al. <i>Agaricus blazei</i>-Based Mushroom Extract Supplementation to Birch Allergic Blood Donors: A Randomized Clinical Trial. Nutrients. 2019 Oct;11(10):E2339. DOI: 10.3390/nu11102339. PMID: 31581605; PMCID: PMC6836217.
https://europepmc.org/article/MED/31581605
213. Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E. Effect of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, on Symptoms, Fatigue and Quality of Life in Patients with Ulcerative Colitis in a Randomized Single-Blinded Placebo Controlled Study. Plos one. 2016 ;11(3):e0150191. DOI: 10.1371/journal.pone.0150191. PMID: 26933886; PMCID: PMC4774976.
https://europepmc.org/article/MED/26933886
214. Therkelsen SP, Hetland G, Lyberg T, Lygren I, Johnson E. Effect of the Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSanTM, on Symptoms, Fatigue and Quality of Life in Patients with Crohn's Disease in a Randomized Single-Blinded Placebo Controlled Study. PLoS One. 2016 Jul 14;11(7):e0159288. doi: 10.1371/journal.pone.0159288. PMID: 27415795; PMCID: PMC4944955.
https://europepmc.org/article/MED/27415795
215. Cytokine Levels After Consumption of a Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSan™, in Patients with Crohn's Disease and Ulcerative Colitis in a Randomized Single-Blinded Placebo-Controlled Study S. P. Therkelsen, G. Hetland, T. Lyberg, I. Lygren, E. Johnson
https://onlinelibrary.wiley.com/doi/10.1111/sji.12476
216. Tangen JM, Tierens A, Caers J, Binsfeld M, Olstad OK, Trøseid AM, Wang J, Tjønnfjord GE, Hetland G. Immunomodulatory effects of the Agaricus blazei Murrill-based mushroom extract AndoSan in patients with multiple myeloma undergoing high dose chemotherapy and autologous stem cell transplantation: a randomized, double blinded clinical study. Biomed Res Int. 2015;2015:718539. doi: 10.1155/2015/718539. Epub 2015 Jan 18. PMID: 25664323; PMCID: PMC4312620.
https://pubmed.ncbi.nlm.nih.gov/25664323/
217. Hetland, Geir. (2015). Andosan?-An Anti-Allergic and Anti-Inflammatory Ingredient Prepared from Agaricus blazei Mushroom. Journal of Clinical and Cellular Immunology. 06. 10.4172/2155-9899.1000320.
https://www.researchgate.net/publication/277886112_Andosan-An_Anti-Allergic_and_Anti-Inflammatory_Ingredient_Prepared_from_Agaricus_blazei_Mushroom
218. Song HN. Functional Cordyceps Coffee Containing Cordycepin and β-Glucan. Prev Nutr Food Sci. 2020 Jun 30;25(2):184-193. doi: 10.3746/pnf.2020.25.2.184. PMID: 32676470; PMCID: PMC7333010.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7333010/
219. Should you switch to mushroom coffee?, August 7, 2023, UCLA
https://www.uclahealth.org/news/article/should-you-switch-mushroom-coffee
220. Mushroom coffee: Worth a taste? June 4, 2024 By Lindsay Warner, Content Licensing Editor, Harvard Health Publishing
https://www.health.harvard.edu/nutrition/mushroom-coffee-worth-a-taste
221. August 14, 2024 Mushroom Coffee: An Evidence-Based Review Written By Megan Giec Perry PA-C
https://www.rupahealth.com/post/mushroom-coffee-an-evidence-based-review
222. Public Notification: Lishou Slimming Coffee contains hidden drug ingredients, FDA,
https://www.fda.gov/drugs/medication-health-fraud/public-notification-lishou-slimming-coffee-contains-hidden-drug-ingredients
223. Medsafe is issuing a warning that Valentus SlimROAST Optimum Dark Roast Coffee should not be consumed – statement under section 98 of the Medicines Act 1981 11 October 2019
https://www.medsafe.govt.nz/safety/Alerts/ValentusSlimRoast.asp
224. Sachchida Nand Rai, Divya Mishra, Payal Singh, Emanuel Vamanu, M.P. Singh, Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases, Biomedicine & Pharmacotherapy, Volume 137, 2021, 111377, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2021.111377.
https://www.sciencedirect.com/science/article/pii/S0753332221001621
225. Phan CW, David P, Naidu M, Wong KH, Sabaratnam V. Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism. Crit Rev Biotechnol. 2015;35(3):355-68. doi: 10.3109/07388551.2014.887649. PMID: 24654802.
https://pubmed.ncbi.nlm.nih.gov/24654802/
226. Kim-McManus O, Boylan S, Nespeca M. Serendipity Can Rule the Day: Remarkable Efficacy of a Mushroom Extract Powder in Childhood Treatment-Resistant Epilepsy. Pediatr Neurol. 2025 Apr;165:56-59. doi: 10.1016/j.pediatrneurol.2025.01.017. Epub 2025 Jan 24. PMID: 39951934.
https://pubmed.ncbi.nlm.nih.gov/39951934/
227. Ganesan K, Xu B. Anti-Obesity Effects of Medicinal and Edible Mushrooms. Molecules. 2018 Nov 5;23(11):2880. doi: 10.3390/molecules23112880. PMID: 30400600; PMCID: PMC6278646.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6278646/
228. Precious U. Ezurike, Evelyn Odunola, Tolulope A. Oke, Adewale G. Bakre, Oluwayimika Olumide, OgoOluwa Odetoye, Adenike M. Alege, Oyindamola O. Abiodun, Ganoderma lucidum ethanol extract promotes weight loss and improves depressive-like behaviors in male and female Swiss mice, Physiology & Behavior, Volume 265, 2023, 114155, ISSN 0031-9384, https://doi.org/10.1016/j.physbeh.2023.114155.
https://www.sciencedirect.com/science/article/abs/pii/S0031938423000835
229. Eshita Sharma, Rakesh Bairwa, Priyanka Lal, Sudeepta Pattanayak, Kota Chakrapani, Rajendra Poorvasandhya, Awadhesh Kumar, Muhammad Ahsan Altaf, Rahul Kumar Tiwari, Milan Kumar Lal, Ravinder Kumar, Edible mushrooms trending in food: Nutrigenomics, bibliometric, from bench to valuable applications, Heliyon, Volume 10, Issue 17, 2024, e36963, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2024.e36963.
https://www.sciencedirect.com/science/article/pii/S2405844024129945
230. Choi WS, Kim YS, Park BS, Kim JE, Lee SE. Hypolipidaemic Effect of Hericium erinaceum Grown in Artemisia capillaris on Obese Rats. Mycobiology. 2013 Jun;41(2):94-9. doi: 10.5941/MYCO.2013.41.2.94. Epub 2013 Jun 30. PMID: 23874132; PMCID: PMC3714447.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3714447/
231. Grozier CD, Alves VA, Killen LG, Simpson JD, O'Neal EK, Waldman HS. Four Weeks of Hericium erinaceus Supplementation Does Not Impact Markers of Metabolic Flexibility or Cognition. Int J Exerc Sci. 2022 Oct 1;15(2):1366-1380. doi: 10.70252/XZKO8571. PMID: 36582308; PMCID: PMC9762243.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9762243/
232. Teja KS, Suruchi, Rai U, Kumar M, Mohanty O, Roy J, Meshram S. Mushrooms: A Potential Option in the Management of Deficiency and Diseases in Humans. J Pure Appl Microbiol. 2023;17(2):749-760. doi: 10.22207/JPAM.17.2.55
https://microbiologyjournal.org/mushrooms-a-potential-option-in-the-management-of-deficiency-and-diseases-in-humans/
233. Volume 1, Issue 2 (November 2022), Health Science Monitor 2022, 1(2): 107-108 Does Ganoderma lucidum reduce obesity? Ameneh Marzban , Abdolrazagh Marzban , Payam Emami * Department of Emergency Medical Sciences, School of Paramedical Sciences, Kurdistan University of Medical Sciences, Sanandaj, Iran
https://hsm.umsu.ac.ir/browse.php?a_id=46&sid=1&slc_lang=en
234. Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan, Xuefei Yang, A concise review of mushrooms antiviral and immunomodulatory properties that may combat against COVID-19, Food Chemistry Advances, Volume 1, 2022, 100023, ISSN 2772-753X, https://doi.org/10.1016/j.focha.2022.100023.
https://www.sciencedirect.com/science/article/pii/S2772753X22000120
235. Ruth W. Mwangi, John M. Macharia, Isabel N. Wagara, Raposa L. Bence, The antioxidant potential of different edible and medicinal mushrooms, Biomedicine & Pharmacotherapy, Volume 147, 2022, 112621, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2022.112621.
https://www.sciencedirect.com/science/article/pii/S0753332222000099
236. Elsayed EA, El Enshasy H, Wadaan MA, Aziz R. Mushrooms: a potential natural source of anti-inflammatory compounds for medical applications. Mediators Inflamm. 2014;2014:805841. doi: 10.1155/2014/805841. Epub 2014 Nov 23. PMID: 25505823; PMCID: PMC4258329.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4258329/
237. Manna P, Jain SK. Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies. Metab Syndr Relat Disord. 2015 Dec;13(10):423-44. doi: 10.1089/met.2015.0095. PMID: 26569333; PMCID: PMC4808277.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4808277/
238. Theresa V. Rohm, Daniel T. Meier, Jerrold M. Olefsky, Marc Y. Donath, Inflammation in obesity, diabetes, and related disorders, Immunity, Volume 55, Issue 1, 2022, Pages 31-55, ISSN 1074-7613, https://doi.org/10.1016/j.immuni.2021.12.013.
https://www.sciencedirect.com/science/article/pii/S1074761321005495
239. Bilal, Ahmad & Wani, Bilal & Bodha, R & Wani, Ab. Hamid. (2010). Nutritional and medicinal importance of mushrooms. Journal of Medicinal Plants Research. 4. 10.5897/JMPR09.565.
https://www.researchgate.net/publication/266012160_Nutritional_and_medicinal_importance_of_mushrooms
240. Holmes, D. Medicinal mushroom reduces obesity by modulating microbiota. Nat Rev Endocrinol 11, 504 (2015). https://doi.org/10.1038/nrendo.2015.114
https://www.nature.com/articles/nrendo.2015.114#citeas
241. Stamatia-Angeliki Kleftaki, Stamatia Simati, Charalampia Amerikanou, Aristea Gioxari, Chara Tzavara, Georgios I. Zervakis, Nick Kalogeropoulos, Alexander Kokkinos, Andriana C. Kaliora, Pleurotus eryngii improves postprandial glycaemia, hunger and fullness perception, and enhances ghrelin suppression in people with metabolically unhealthy obesity, Pharmacological Research, Volume 175, 2022, 105979, ISSN 1043-6618, https://doi.org/10.1016/j.phrs.2021.105979.
https://www.sciencedirect.com/science/article/abs/pii/S1043661821005636
242. Németh, Z.; Paulinné Bukovics, M.; Sümegi, L.D.; Sturm, G.; Takács, I.; Simon-Szabó, L. The Importance of Edible Medicinal Mushrooms and Their Potential Use as Therapeutic Agents Against Insulin Resistance. Int. J. Mol. Sci. 2025, 26, 827. https://doi.org/10.3390/ijms26020827
https://www.mdpi.com/1422-0067/26/2/827
243. Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, Ohnuki K. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res. 2010 Aug;31(4):231-7. doi: 10.2220/biomedres.31.231. PMID: 20834180.
https://pubmed.ncbi.nlm.nih.gov/20834180/
244. Son EH, Jung DH, Shin H, Lee S, Kim Y, Lim HS. Effects of the Intestinal Status and Clinical Factors of Korean Middle-Aged People Through the Consumption of Functional Foods Containing Auricularia auricula-judae Powder: Prospective, Randomized, Open-Label, and Control Comparative Trial. Clin Nutr Res. 2025 Jan 22;14(1):7-16. doi: 10.7762/cnr.2025.14.1.7. PMID: 39968271; PMCID: PMC11832288.
https://pubmed.ncbi.nlm.nih.gov/39968271/
245. Nutrients. 2021 Mar 21;13(3):1008. doi: 10.3390/nu13031008. Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study Xiao-Qian Xie, Yan Geng, Qijie Guan, Yilin Ren, Lin Guo, Qiqi Lv, Zhen-Ming Lu, Jin-Song Shi, Zheng-Hong Xu.
https://pubmed.ncbi.nlm.nih.gov/33800983/
246. Gut microbiome makeup can determine ability to lose weight, UCLA Health, November 24, 2021
https://www.uclahealth.org/news/article/gut-microbiome-makeup-can-determine-ability-to-lose-weight
247. Jian, C., Silvestre, M.P., Middleton, D. et al. Gut microbiota predicts body fat change following a low-energy diet: a PREVIEW intervention study. Genome Med 14, 54 (2022). https://doi.org/10.1186/s13073-022-01053-7
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-022-01053-7
248. Małgorzata Moszak, Marta Pelczyńska, Agnieszka Wesołek, Dominika Stenclik, Paweł Bogdański, Does gut microbiota affect the success of weight loss? Evidence and speculation, Nutrition, Volume 116, 2023, 112111, ISSN 0899-9007, https://doi.org/10.1016/j.nut.2023.112111.
https://www.sciencedirect.com/science/article/pii/S0899900723001405
249. Li, H., Zhang, L., Li, J. et al. Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota. Nat Metab 6, 578–597 (2024). https://doi.org/10.1038/s42255-024-00988-y
https://www.nature.com/articles/s42255-024-00988-y
250. Hearing Loss & Tinnitus Statistics, Hearing Health Foundation
https://hearinghealthfoundation.org/hearing-loss-tinnitus-statistics
251. Int J Med Mushrooms, 19 (4), 279-317 2017 Medicinal Mushrooms in Human Clinical Studies. Part I. Anticancer, Oncoimmunological, and Immunomodulatory Activities: A Review Solomon P Wasser
https://pubmed.ncbi.nlm.nih.gov/28605319
252. Biomed J, 37 (6), 345-56 Nov-Dec 2014 Medicinal Mushroom Science: Current Perspectives, Advances, Evidences, and Challenges Solomon P Wasser
https://pubmed.ncbi.nlm.nih.gov/25179726
253. Karthiyayini Balakrishnan, Sanjushree Nagarajan, Gowdhami Balakrishnan, Muthuselvam Manickam, Dhanasekaran Dharumadurai, Chapter 15 - Symbiotic microbial interactions in medicinal mushroom: an insight of phenotypic and genotypic characterization methods, Editor(s): Dhanasekaran Dharumadurai, In Developments in Applied Microbiology and Biotechnology, Microbial Symbionts, Academic Press, 2023, Pages 277-294, ISBN 9780323993340
https://www.sciencedirect.com/topics/immunology-and-microbiology/medicinal-mushroom
254. Fungi as Future Medicine: The Therapeutic Potential of Mushrooms, Dr. Sanchari Sinha Dutta, Ph.D., News-Medical.Net ,
https://www.news-medical.net/health/Fungi-as-Future-Medicine-The-Therapeutic-Potential-of-Mushrooms.aspx
255. Chemical and Pharmacological Investigations of Fomitopsis betulina (formerly: Piptoporus betulinus) and Calvatia gigantea, Inauguraldissertation zur Erlangung des akademischen Grades doctor rerum naturalium (Dr. rer. nat.) an der Mathematisch-Naturwissenschaftlichen Fakultät der Ernst-Moritz-Arndt-Universität Greifswald, Greifswald, Februar 2019
https://epub.ub.uni-greifswald.de/frontdoor/deliver/index/docId/3477/file/Dissertation-Alresly.pdf
256. Wasser, Solomon. (2017). Medicinal Properties and Clinical Effects of Medicinal Mushrooms: Technology and Applications. 10.1002/9781119149446.ch22.
https://www.researchgate.net/publication/319118336_Medicinal_Properties_and_Clinical_Effects_of_Medicinal_Mushrooms_Technology_and_Applications
257. Jia L-F, Chen P, Qu G-D, et al. A comprehensive review of the sedative-hypnotic mechanisms of edible fungi. Food & Medicine Homology, 2025, https://doi.org/10.26599/FMH.2025.9420049
https://www.sciopen.com/article/10.26599/FMH.2025.9420049
258. Wei Chen, Jun-Wen Yu, Yu-Yi Deng, Lut Yi Wong, Chen Wang, Yu-Ling Liang, Yuk-Tung Leung, Jia-Yi Tian, Ying Wu, Kelvin Sze-Yin Leung, Jinhui Hu, Wen-Hua Chen, Xiaobing Dou, Xiu-Qiong Fu, Ying-Jie Chen, Zhi-Ling Yu, Identification of sedative-hypnotic compounds shared by five medicinal Polyporales mushrooms using UPLC-Q-TOF-MS/MS-based untargeted metabolomics, Phytomedicine, Volume 128, 2024, 155355, ISSN 0944-7113, https://doi.org/10.1016/j.phymed.2024.155355.
https://www.sciencedirect.com/science/article/abs/pii/S0944711324000205
259. Tselepis, George & Palamiotis, Ioannis & Georgiou, Sofia. (2023). Homeostasis of Circadian Rhythm and Therapeutic Approaches to Manage its Related-Disorders: The Case of Medicinal Mushrooms Rich in Melatonin. Med Discoveries. 2. 10.52768/2993-1142/1075.
https://www.researchgate.net/publication/375439212_Homeostasis_of_Circadian_Rhythm_and_Therapeutic_Approaches_to_Manage_its_Related-Disorders_The_Case_of_Medicinal_Mushrooms_Rich_in_Melatonin
260. Lu J, Su M, Zhou X, Li D, Niu X, Wang Y. Research Progress of Bioactive Components in Sanghuangporus spp. Molecules. 2024 Mar 7;29(6):1195. doi: 10.3390/molecules29061195. PMID: 38542832; PMCID: PMC10976032.
https://pubmed.ncbi.nlm.nih.gov/38542832/
261. Yao L, Lv J, Duan C, An X, Zhang C, Li D, Li C, Liu S. Armillaria mellea fermentation liquor ameliorates p-chlorophenylalanine-induced insomnia associated with the modulation of serotonergic system and gut microbiota in rats. J Food Biochem. 2022 Feb;46(2):e14075. doi: 10.1111/jfbc.14075. Epub 2022 Jan 5. PMID: 34984694.
https://pubmed.ncbi.nlm.nih.gov/34984694/
262. Sharma H, Sharma N, An SSA. Unique Bioactives from Zombie Fungus (Cordyceps) as Promising Multitargeted Neuroprotective Agents. Nutrients. 2023 Dec 27;16(1):102. doi: 10.3390/nu16010102. PMID: 38201932; PMCID: PMC10780653.
https://pubmed.ncbi.nlm.nih.gov/38201932/
263. Tan YF, Mo JS, Wang YK, Zhang W, Jiang YP, Xu KP, Tan GS, Liu S, Li J, Wang WX. The ethnopharmacology, phytochemistry and pharmacology of the genus Hericium. J Ethnopharmacol. 2024 Jan 30;319(Pt 3):117353. doi: 10.1016/j.jep.2023.117353. Epub 2023 Oct 29. PMID: 37907145.
https://pubmed.ncbi.nlm.nih.gov/37907145/
264. Published April 20, 2009 COMPLEMENTARY and ALTERNATIVE MEDICINE Adaptogenic or Medicinal Mushrooms M. Saljoughian, PharmD, PhD
https://www.uspharmacist.com/article/adaptogenic-or-medicinal-mushrooms
265. Yao, C., Wang, Z., Jiang, H. et al. Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice. Sci Rep 11, 13660 (2021). https://doi.org/10.1038/s41598-021-92913-6
https://www.nature.com/articles/s41598-021-92913-6
266. Batra P, Sharma AK, Khajuria R. Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. Int J Med Mushrooms. 2013;15(2):127-43. doi: 10.1615/intjmedmushr.v15.i2.20. PMID: 23557365.
https://pubmed.ncbi.nlm.nih.gov/23557365/
267. Lee KH, Morris-Natschke SL, Yang X, Huang R, Zhou T, Wu SF, Shi Q, Itokawa H. Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine. J Tradit Complement Med. 2012 Apr;2(2):84-95. PMID: 24716120; PMCID: PMC3942920.
https://core.ac.uk/download/pdf/82062841.pdf
268. Reishi Cultivation The mushroom of immortality, Michael den Herder, European Forest Institute, [email protected] April 2022
https://efi.int/sites/default/files/files/knowledge/projects/EFI_Reishi_Cultivation_EN.pdf
269. Sanodiya BS, Thakur GS, Baghel RK, Prasad GB, Bisen PS. Ganoderma lucidum: a potent pharmacological macrofungus. Curr Pharm Biotechnol. 2009 Dec;10(8):717-42. doi: 10.2174/138920109789978757. PMID: 19939212.
https://pubmed.ncbi.nlm.nih.gov/19939212/
270. Yao C, Wang Z, Jiang H, Yan R, Huang Q, Wang Y, Xie H, Zou Y, Yu Y, Lv L. Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice. Sci Rep. 2021 Jul 1;11(1):13660. doi: 10.1038/s41598-021-92913-6. PMID: 34211003; PMCID: PMC8249598.
https://pubmed.ncbi.nlm.nih.gov/34211003/
271. Xiang-Yu Cui, Su-Ying Cui, Juan Zhang, Zi-Jun Wang, Bin Yu, Zhao-Fu Sheng, Xue-Qiong Zhang, Yong-He Zhang, Extract of Ganoderma lucidum prolongs sleep time in rats, Journal of Ethnopharmacology, Volume 139, Issue 3, 2012, Pages 796-800, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2011.12.020.
https://www.sciencedirect.com/science/article/abs/pii/S0378874111008981
272. Angelini, Paola & Girometta, Carolina & Venanzoni, Roberto & Bertuzzi, Gianluigi. (2022). Anti-Aging Properties of Medicinal Mushrooms in Systemic Aesthetic Medicine. 10.1007/978-981-16-6257-7_7.
https://www.researchgate.net/publication/359317471_Anti-Aging_Properties_of_Medicinal_Mushrooms_in_Systemic_Aesthetic_Medicine
273. Kumar, Nanjangud & Quispe, Cristina & Herrera, Jesús & Herrera Belén, Lisandra & Loren Reyes, Pía & Salazar, Luis & Silva, Victor & Orhan, Ilkay & Senol Deniz, Fatma & Nemli, Elifsu & Capanoglu, Esra & Olatunde, Ahmed & Silva, Nathalia & Živković, Jelena & Shorog, Eman & Calina, Daniela & Sharifi-Rad, Javad. (2023). Potential of Mushrooms Bioactive for the Treatment of Skin Diseases and Disorders. Journal of Food Biochemistry. 2023. 1-26. 10.1155/2023/5915769.
https://www.researchgate.net/publication/376450794_Potential_of_Mushrooms_Bioactive_for_the_Treatment_of_Skin_Diseases_and_Disorders
274. Fordjour E, Manful CF, Javed R, Galagedara LW, Cuss CW, Cheema M, Thomas R. Chaga mushroom: a super-fungus with countless facets and untapped potential. Front Pharmacol. 2023 Dec 5;14:1273786. doi: 10.3389/fphar.2023.1273786. PMID: 38116085; PMCID: PMC10728660.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10728660/
275. Burlec, A.F.; Hăncianu, M.; Ivănescu, B.; Macovei, I.; Corciovă, A. Exploring the Therapeutic Potential of Natural Compounds in Psoriasis and Their Inclusion in Nanotechnological Systems. Antioxidants 2024, 13, 912. https://doi.org/10.3390/antiox13080912
https://www.mdpi.com/2076-3921/13/8/912
276. personal care, skin diseases Psoriasis – Plant-based Approach to Strengthen the Skin’s Immune System S. Hettwer, E. Besic Gyenge, B. Suter, B. Obermayer
https://www.rahn-group.com/en/rahn/download-document/845ab00f-9b60-4457-8f65-4162f5f81add/pd_literature_liftonin-qi_techpaper_sofw_2206_enp001621675.pdf
277. What are the benefits of lion’s mane mushrooms? Medically reviewed by Kim Rose-Francis RDN, CDCES, LD, Nutrition — Written by Jayne Leonard — Updated on December 10, 2024
https://www.medicalnewstoday.com/articles/323400
278. Németh, Z.; Paulinné Bukovics, M.; Sümegi, L.D.; Sturm, G.; Takács, I.; Simon-Szabó, L. The Importance of Edible Medicinal Mushrooms and Their Potential Use as Therapeutic Agents Against Insulin Resistance. Int. J. Mol. Sci. 2025, 26, 827. https://doi.org/10.3390/ijms26020827
https://www.mdpi.com/1422-0067/26/2/827
279. Kiho T, Yamane A, Hui J, Usui S, Ukai S. Polysaccharides in fungi. XXXVI. Hypoglycemic activity of a polysaccharide (CS-F30) from the cultural mycelium of Cordyceps sinensis and its effect on glucose metabolism in mouse liver. Biol Pharm Bull. 1996 Feb;19(2):294-6. doi: 10.1248/bpb.19.294. PMID: 8850325.
https://www.jstage.jst.go.jp/article/bpb1993/19/2/19_2_294/_article
280. Hypolipidemic effect of exo- and endo-biopolymers produced from submerged mycelial culture of Ganoderma lucidum in rats By: Yang, Byung-Keun Journal of Microbiology and Biotechnology (2002), 12(6), 872-877 CODEN: JOMBES; ISSN: 1017-7825
https://chemport-n.cas.org//chemport-n/?APP=ftslink&action=reflink&origin=npg&version=1.0&coi=1%3ACAS%3A528%3ADC%2BD3sXhvVyrs7s%3D&md5=81df50e26d135d0e7d203517b6259c6e
281. L. Liang, Z. Zhang, W. Sun and Y. Wang, "Effect of the Inonotus Obliquus Polysaccharides on Blood Lipid Metabolism and Oxidative Stress of Rats Fed High-Fat Diet In Vivo," 2009 2nd International Conference on Biomedical Engineering and Informatics, Tianjin, China, 2009, pp. 1-4, doi: 10.1109/BMEI.2009.5305591.
https://ieeexplore.ieee.org/document/5305591
282. Kim, SY., Chung, SI., Nam, SH. et al. Cholesterol lowering action and antioxidant status improving efficacy of noodles made from unmarketable oak mushroom (Lentinus edodes) in high cholesterol fed rats. J. Korean Soc. Appl. Biol. Chem. 52, 207–212 (2009). https://doi.org/10.3839/jksabc.2009.038
https://applbiolchem.springeropen.com/articles/10.3839/jksabc.2009.038#citeas
283. Hiwatashi K, Kosaka Y, Suzuki N, Hata K, Mukaiyama T, Sakamoto K, Shirakawa H, Komai M. Yamabushitake mushroom (Hericium erinaceus) improved lipid metabolism in mice fed a high-fat diet. Biosci Biotechnol Biochem. 2010;74(7):1447-51. doi: 10.1271/bbb.100130. Epub 2010 Jul 7. PMID: 20622452.
https://pubmed.ncbi.nlm.nih.gov/20622452/
284. Handayani, Dian & Chen, J & Meyer, B & Huang, Xu-Feng. (2011). Dietary Shiitake Mushroom (Lentinus edodes) Prevents Fat Deposition and Lowers Triglyceride in Rats Fed a High-Fat Diet. Journal of obesity. 2011. 258051. 10.1155/2011/258051.
https://www.researchgate.net/publication/51746881_Dietary_Shiitake_Mushroom_Lentinus_edodes_Prevents_Fat_Deposition_and_Lowers_Triglyceride_in_Rats_Fed_a_High-Fat_Diet
285. Choi WS, Kim YS, Park BS, Kim JE, Lee SE. Hypolipidaemic Effect of Hericium erinaceum Grown in Artemisia capillaris on Obese Rats. Mycobiology. 2013 Jun;41(2):94-9. doi: 10.5941/MYCO.2013.41.2.94. Epub 2013 Jun 30. PMID: 23874132; PMCID: PMC3714447.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3714447/
286. Henriques, Gilberto & Helm, Cristiane & Busato, Ana & Simeone, Maria. (2016). Lipid profile and glycemic response of rats fed on a semi-purified diet supplemented with Agaricus brasiliensis mushroom. Acta Scientiarum. Health Sciences. 38. 71. 10.4025/actascihealthsci.v38i1.29185.
https://www.redalyc.org/journal/3072/307245984010/html/
287. Anwar H, Suchodolski JS, Ullah MI, Hussain G, Shabbir MZ, Mustafa I, Sohail MU. Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Supplementation Alters Gut Microbiome and Corrects Dyslipidemia in Rats. Int J Med Mushrooms. 2019;21(1):79-88. doi: 10.1615/IntJMedMushrooms.2018029348.
https://qspace.qu.edu.qa/handle/10576/11369?show=full
288. Olaide Olawunmi Ajibola, Cirilo Nolasco-Hipolito, Octavio Carvajal-Zarrabal, Shanti F Salleh, Gbadebo C Adeyinka, Stephen A Adefegha, Mirja K Ahmmed, Kazi Sumaiya, Raymond Thomas, Turkey tail mushroom (Trametes versicolor): an edible macrofungi with immense medicinal properties, Current Opinion in Food Science, Volume 58, 2024, 101191, ISSN 2214-7993, https://doi.org/10.1016/j.cofs.2024.101191.
https://www.sciencedirect.com/science/article/pii/S2214799324000699
289. African Journal of Biotechnology Vol. 5 (13), pp. 1263-1266, 3 July 2006 Available online at http://www.academicjournals.org/AJB ISSN 1684–5315 © 2006 Academic Journals. Responses of plasma lipids to edible mushroom diets in albino rats Oyetayo, F.L Department of Biochemistry, University of Ado-Ekiti, Nigeria. E-mail: [email protected].
https://www.ajol.info/index.php/ajb/article/view/43095
290. alzdiscovery.org. Lion's mane, 8/9/2026
https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Lions-Mane-Cognitive-Vitality-For-Researchers.pdf
291. Samarasinghe, M W A Kanchana Priyadarshani & Waisundara, Viduranga. (2020). Therapeutic Properties and Anti-Lipidemic Activity of Cordyceps sinensis. 10.5772/intechopen.92616.
https://www.intechopen.com/chapters/72232
292. Phillips, J.M.; Ooi, S.L.; Pak, S.C. Health-Promoting Properties of Medicinal Mushrooms and Their Bioactive Compounds for the COVID-19 Era—An Appraisal: Do the Pro-Health Claims Measure Up? Molecules 2022, 27, 2302. https://doi.org/10.3390/ molecules27072302
https://researchoutput.csu.edu.au/ws/portalfiles/portal/347095015/213340870_Published_article.pdf
293. Bhambri A, Srivastava M, Mahale VG, Mahale S and Karn SK (2022) Mushrooms as Potential Sources of Active Metabolites and Medicines. Front. Microbiol. 13:837266. doi: 10.3389/fmicb.2022.837266
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.837266/full
294. Consuming Mushrooms When Adopting a Healthy Mediterranean-Style Dietary Pattern Does Not Influence Short-Term Changes of Most Cardiometabolic Disease Risk Factors in Healthy Middle-Aged and Older Adults Uffelman, Cassi N et al. The Journal of Nutrition, Volume 154, Issue 2, 574 - 582
https://jn.nutrition.org/article/S0022-3166(23)72815-0/fulltext
295. Fritz, H.; Kennedy, D.A.; Ishii, M.; Fergusson, D.; Fernandes, R.; Cooley, K.; Seely, D. Polysaccharide K and Coriolus versicolor Extracts for Lung Cancer. Integr. Cancer Ther. 2015, 14, 201–211.
https://pubmed.ncbi.nlm.nih.gov/25784670/
296. Shahid A, Chen M, Yeung S, Parsa C, Orlando R, Huang Y. The medicinal mushroom Ganoderma lucidum prevents lung tumorigenesis induced by tobacco smoke carcinogens. Front Pharmacol. 2023 Sep 6;14:1244150. doi: 10.3389/fphar.2023.1244150. PMID: 37745066; PMCID: PMC10516555.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10516555/
297. Sangtitanu, T.; Sangtanoo, P.; Srimongkol, P.; Saisavoey, T.; Reamtong, O.; Karnchanatat, A. Peptides obtained from edible mushrooms: Hericium erinaceus offers the ability to scavenge free radicals and induce apoptosis in lung cancer cells in humans. Food Funct. 2020, 11, 4927–4939.
https://pubs.rsc.org/en/content/articlelanding/2020/fo/d0fo00227e/unauth
298. Mihi Yang, Hee-Kyung Jang, Huiwon Kang. How do shiitake and reishi mushrooms work on lung cancer?: A high throughput screening of 3D cell culture. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4553.
https://aacrjournals.org/cancerres/article/83/7_Supplement/4553/724521/Abstract-4553-How-do-shiitake-and-reishi-mushrooms
299. Park, S.E.; Yoo, H.S.; Jin, C.-Y.; Hong, S.H.; Lee, Y.-W.; Kim, B.W.; Lee, S.H.; Kim, W.-J.; Cho, C.K.; Choi, Y.H. Induction of apoptosis and inhibition of telomerase activity in human lung carcinoma cells by the water extract of Cordyceps militaris. Food Chem. Toxicol. 2009, 47, 1667–1675.
https://www.sciencedirect.com/science/article/abs/pii/S0278691509001744
300. Hsu, W.-H.; Qiu, W.-L.; Tsao, S.-M.; Tseng, A.-J.; Lu, M.-K.; Hua, W.-J.; Cheng, H.-C.; Hsu, H.-Y.; Lin, T.-Y. Effects of WSG, a polysaccharide from Ganoderma lucidum, on suppressing cell growth and mobility of lung cancer. Int. J. Biol. Macromol. 2020, 165, 1604–1613.
https://pubmed.ncbi.nlm.nih.gov/33011264/
301. Spandidos Publications style Loganathan J, Jiang J, Smith A, Jedinak A, Thyagarajan-Sahu A, Sandusky GE, Nakshatri H and Sliva D: The mushroom Ganoderma lucidum suppresses breast-to-lung cancer metastasis through the inhibition of pro-invasive genes. Int J Oncol 44: 2009-2015, 2014.
https://www.spandidos-publications.com/10.3892/ijo.2014.2375
302. Lai, Wei & Zainal, Zamri & Daud, Fauzi. (2014). Preliminary study on the potential of polysaccharide from indigenous Tiger's Milk mushroom (Lignosus rhinocerus) as anti-lung cancer agent. 1614. 517-519. 10.1063/1.4895252.
https://www.researchgate.net/publication/299862394_Preliminary_study_on_the_potential_of_polysaccharide_from_indigenous_Tiger%27s_Milk_mushroom_Lignosus_rhinocerus_as_anti-lung_cancer_agent
https://www.spandidos-publications.com/10.3892/ijo.2014.2375
303. Secme M, Kaygusuz O, Eroglu C, Dodurga Y, Colak OF, Atmaca P. Potential Anticancer Activity of the Parasol Mushroom, Macrolepiota procera (Agaricomycetes), against the A549 Human Lung Cancer Cell Line. Int J Med Mushrooms. 2018;20(11):1075-1086. doi: 10.1615/IntJMedMushrooms.2018028589. PMID: 30806231.
https://www.dl.begellhouse.com/journals/708ae68d64b17c52,6e2de2a705b6ffd3,11ce65196897bbc7.html
304. Huo, Xiaowei & Liu, Chenqi & Bai, Xuelian & Li, Wenjia & Li, Jing & Hu, Xuefeng & Cao, Li. (2017). Aqueous extract of Cordyceps sinensis potentiates the antitumor effect of DDP and attenuates therapy-associated toxicity in non-small cell lung cancer via IκBα/NFκB and AKT/MMP2/MMP9 pathways. RSC Adv.. 7. 37743-37754. 10.1039/C7RA04716A.
https://www.researchgate.net/publication/318820879_Aqueous_extract_of_Cordyceps_sinensis_potentiates_the_antitumor_effect_of_DDP_and_attenuates_therapy-associated_toxicity_in_non-small_cell_lung_cancer_via_IkBaNFkB_and_AKTMMP2MMP9_pathways
305. Bizarro A, Ferreira IC, Soković M, van Griensven LJ, Sousa D, Vasconcelos MH, Lima RT. Cordyceps militaris (L.) Link Fruiting Body Reduces the Growth of a Non-Small Cell Lung Cancer Cell Line by Increasing Cellular Levels of p53 and p21. Molecules. 2015 Jul 31;20(8):13927-40. doi: 10.3390/molecules200813927. PMID: 26263965; PMCID: PMC6332316.
https://pubmed.ncbi.nlm.nih.gov/26263965/
306. Khunoana ET, Nkadimeng SM. Current Advances in the Use of Mushrooms as Therapeutics for Lung Cancer: A Review. Molecules. 2025 Mar 14;30(6):1322. doi: 10.3390/molecules30061322. PMID: 40142097; PMCID: PMC11944945.
https://pubmed.ncbi.nlm.nih.gov/40142097/
307. WHO, Cervical cancer 5 March 2024,
https://www.who.int/news-room/fact-sheets/detail/cervical-cancer
308. Jie Wu, Qianyun Jin, Yunmeng Zhang, Yuting Ji, Jingjing Li, Xiaomin Liu, Hongyuan Duan, Zhuowei Feng, Ya Liu, Yacong Zhang, Zhangyan Lyu, Lei Yang, Yubei Huang, Global burden of cervical cancer: current estimates, temporal trend and future projections based on the GLOBOCAN 2022, Journal of the National Cancer Center, 2025, , ISSN 2667-0054, https://doi.org/10.1016/j.jncc.2024.11.006.
https://www.sciencedirect.com/science/article/pii/S2667005425000134
309. Cervical Cancer Leads Cancer Deaths for Women in 37 Countries, July 29, 2024 Sandy McDowell | Managing Editor Research Written by: Sandy McDowell Editorial Director, Digital Research Content, American Cancer Society
https://www.cancer.org/research/acs-research-news/cervical-cancer-leads-cancer-deaths-37-countries.html
310. Okunade KS. Human papillomavirus and cervical cancer. J Obstet Gynaecol. 2020 Jul;40(5):602-608. doi: 10.1080/01443615.2019.1634030. Epub 2019 Sep 10. Erratum in: J Obstet Gynaecol. 2020 May;40(4):590. doi: 10.1080/01443615.2020.1713592. PMID: 31500479; PMCID: PMC7062568.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7062568/
311. Medicinal Mushrooms (PDQ®)–Health Professional Version, National Cancer Institute
https://www.cancer.gov/about-cancer/treatment/cam/hp/mushrooms-pdq
312. What Is Stomach Cancer? January 22, 2021 American Cancer Society
https://www.cancer.org/cancer/types/stomach-cancer/about/what-is-stomach-cancer.html
313. Menon G, El-Nakeep S, Babiker HM. Gastric Cancer. [Updated 2024 Oct 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK459142/
314. Zaręba KP, Zińczuk J, Dawidziuk T, Pryczynicz A, Guzińska-Ustymowicz K, Kędra B. Stomach cancer in young people - a diagnostic and therapeutic problem. Prz Gastroenterol. 2019;14(4):283-285. doi: 10.5114/pg.2019.90254. Epub 2019 Dec 20. PMID: 31988675; PMCID: PMC6983757.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6983757/
315. Zhang H, Yang W, Tan X, He W, Zhao L, Liu H, Li G. Long-term relative survival of patients with gastric cancer from a large-scale cohort: a period-analysis. BMC Cancer. 2024 Nov 18;24(1):1420. doi: 10.1186/s12885-024-13141-5. PMID: 39558281; PMCID: PMC11571998.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11571998/
316. Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Prz Gastroenterol. 2019;14(2):89-103. doi: 10.5114/pg.2018.81072. Epub 2019 Jan 6. PMID: 31616522; PMCID: PMC6791134.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6791134/
317. Leon Klimeck, Thomas Heisser, Michael Hoffmeister, Hermann Brenner, Colorectal cancer: A health and economic problem, Best Practice & Research Clinical Gastroenterology, Volume 66, 2023, 101839, ISSN 1521-6918, https://doi.org/10.1016/j.bpg.2023.101839.
https://www.sciencedirect.com/science/article/abs/pii/S1521691823000197
318. Siegel RL, Wagle NS, Cercek A, Smith RA, Jemal A. Colorectal cancer statistics, 2023. CA Cancer J Clin. 2023 May-Jun;73(3):233-254. doi: 10.3322/caac.21772. Epub 2023 Mar 1. PMID: 36856579.
https://pubmed.ncbi.nlm.nih.gov/36856579/
319. Ilyas MIM. Epidemiology of Stage IV Colorectal Cancer: Trends in the Incidence, Prevalence, Age Distribution, and Impact on Life Span. Clin Colon Rectal Surg. 2023 Mar 15;37(2):57-61. doi: 10.1055/s-0043-1761447. PMID: 38322602; PMCID: PMC10843881.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10843881/
320. Mahdy H, Vadakekut ES, Crotzer D. Endometrial Cancer. [Updated 2024 Apr 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK525981/
321. Liu L, Habeshian TS, Zhang J, Peeri NC, Du M, De Vivo I, Setiawan VW. Differential trends in rising endometrial cancer incidence by age, race, and ethnicity. JNCI Cancer Spectr. 2023 Jan 3;7(1):pkad001. doi: 10.1093/jncics/pkad001. PMID: 36625534; PMCID: PMC9904185.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9904185/
322. Spandidos Publications style Hahne JC, Meyer SR, Dietl J and Honig A: The effect of Cordyceps extract and a mixture of Ganoderma lucidum/Agaricus Blazi Murill extract on human endometrial cancer cell lines in vitro. Int J Oncol 45: 373-382, 2014.
https://www.spandidos-publications.com/10.3892/ijo.2014.2414
323. Tsai YT, Kuo PH, Kuo HP, Hsu CY, Lee YJ, Kuo CL, Liu JY, Lee SL, Kao MC. Ganoderma tsugae suppresses the proliferation of endometrial carcinoma cells via Akt signaling pathway. Environ Toxicol. 2021 Mar;36(3):320-327. doi: 10.1002/tox.23037. Epub 2020 Oct 12. PMID: 33044769.
https://pubmed.ncbi.nlm.nih.gov/33044769/
324. Shi M. The Efficacy of Ganoderma lucidum Extracts on Treating Endometrial Cancer: A Network Pharmacology Approach. Reprod Sci. 2024 Jul;31(7):1881-1894. doi: 10.1007/s43032-024-01500-3. Epub 2024 Mar 6. PMID: 38448739; PMCID: PMC11217070.
https://pubmed.ncbi.nlm.nih.gov/38448739/
325. What Are Polyps and Adenomas? University of Rochester Medical Center
https://www.urmc.rochester.edu/conditions-and-treatments/polyps-and-adenomas
326. Adrian C. Bateman, Pathology of colorectal polyps and cancer, Surgery (Oxford), Volume 41, Issue 1, 2023, Pages 15-21, ISSN 0263-9319, https://doi.org/10.1016/j.mpsur.2022.10.011.
https://www.sciencedirect.com/science/article/abs/pii/S0263931922002101
327. Conteduca V, Sansonno D, Russi S, Dammacco F. Precancerous colorectal lesions (Review). Int J Oncol. 2013 Oct;43(4):973-84. doi: 10.3892/ijo.2013.2041. Epub 2013 Jul 29. PMID: 23900573.
https://pubmed.ncbi.nlm.nih.gov/23900573/
328. Munding J, Tannapfel A. Epidemiology of Colorectal Adenomas and Histopathological Assessment of Endoscopic Specimens in the Colorectum. Viszeralmedizin. 2014 Feb;30(1):10-6. doi: 10.1159/000357744. PMID: 26288577; PMCID: PMC4513795.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4513795/
329. https://www.nature.com/articles/s41572-020-00240-3
Llovet, J.M., Kelley, R.K., Villanueva, A. et al. Hepatocellular carcinoma. Nat Rev Dis Primers 7, 6 (2021). https://doi.org/10.1038/s41572-020-00240-3
330. Asafo-Agyei KO, Samant H. Hepatocellular Carcinoma. [Updated 2023 Jun 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK559177/
331. Huitzil-Melendez FD, Capanu M, O'Reilly EM, Duffy A, Gansukh B, Saltz LL, Abou-Alfa GK. Advanced hepatocellular carcinoma: which staging systems best predict prognosis? J Clin Oncol. 2010 Jun 10;28(17):2889-95. doi: 10.1200/JCO.2009.25.9895. Epub 2010 May 10. PMID: 20458042; PMCID: PMC3651603.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3651603/
332. Alves, Rogério & Alves, Daniele & Guz, Betty & Matos, Carla & Viana, Monica & Harriz, Michelle & Terrabuio, Deborah & Kondo, Mario & Gampel, Otávio & Polletti, Paula. (2011). Advanced hepatocellular carcinoma. Review of targeted molecular drugs. Annals of hepatology. 10. 21-7. 10.1016/S1665-2681(19)31582-0.
https://www.elsevier.es/en-revista-annals-hepatology-16-articulo-advanced-hepatocellular-carcinoma-review-targeted-S1665268119315820
333. Kim DW, Talati C, Kim R. Hepatocellular carcinoma (HCC): beyond sorafenib—chemotherapy. J Gastrointest Oncol 2017;8(2):256-265. doi: 10.21037/jgo.2016.09.07
https://jgo.amegroups.org/article/view/9549/html
334. Deng GL, Zeng S, Shen H. Chemotherapy and target therapy for hepatocellular carcinoma: New advances and challenges. World J Hepatol. 2015 Apr 18;7(5):787-98. doi: 10.4254/wjh.v7.i5.787. PMID: 25914779; PMCID: PMC4404384.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4404384/
335. W. Yeo, F.K.F. Mo, J. Koh, A.T.C. Chan, T. Leung, P. Hui, L. Chan, A. Tang, J.J. Lee, T.S.K. Mok, P.B.S. Lai, P.J. Johnson, B. Zee, Quality of life is predictive of survival in patients with unresectable hepatocellular carcinoma, Annals of Oncology, Volume 17, Issue 7, 2006, Pages 1083-1089, ISSN 0923-7534, https://doi.org/10.1093/annonc/mdl065.
https://www.sciencedirect.com/science/article/pii/S0923753419453751
336. Kennedy, A.S., Sangro, B. Nonsurgical Treatment for Localized Hepatocellular Carcinoma. Curr Oncol Rep 16, 373 (2014). https://doi.org/10.1007/s11912-013-0373-x
https://link.springer.com/article/10.1007/s11912-013-0373-x
337. Thomas W. T. Leung, Yehuda Z. Patt, Wan-yee Lau, Stephen K. W. Ho, Simon C. H. Yu, Anthony T. C. Chan, Tony S. K. Mok, Winnie Yeo, Choong-tsek Liew, Nancy W. Y. Leung, Amanda M. Y. Tang, Philip J. Johnson; Complete Pathological Remission Is Possible with Systemic Combination Chemotherapy for Inoperable Hepatocellular Carcinoma. Clin Cancer Res 1 July 1999; 5 (7): 1676–1681.
https://aacrjournals.org/clincancerres/article/5/7/1676/287579/Complete-Pathological-Remission-Is-Possible-with
338. Agirrezabal, I., Pollock, R.F., Carion, P.L. et al. Association of adverse events and quality of life in patients with unresectable hepatocellular carcinoma. Qual Life Res 33, 3377–3386 (2024). https://doi.org/10.1007/s11136-024-03779-w
https://link.springer.com/article/10.1007/s11136-024-03779-w
339. Gandhi S, Khubchandani S, Iyer R. Quality of life and hepatocellular carcinoma. J Gastrointest Oncol 2014;5(4):296-317. doi: 10.3978/j.issn.2078-6891.2014.046
https://jgo.amegroups.org/article/view/2783/html
340. Pathomjaruwat T, Matchim Y, Armer JM. Symptoms and symptom clusters in patients with hepatocellular carcinoma and commonly used instruments: An integrated review. Int J Nurs Sci. 2023 Sep 21;11(1):66-75. doi: 10.1016/j.ijnss.2023.09.009. PMID: 38352278; PMCID: PMC10859590.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10859590/
341. Christian-Miller N, Frenette C. Hepatocellular cancer pain: impact and management challenges. J Hepatocell Carcinoma. 2018 Jul 19;5:75-80. doi: 10.2147/JHC.S145450. PMID: 30050880; PMCID: PMC6055904.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6055904/
342. Sun VC, Sarna L. Symptom management in hepatocellular carcinoma. Clin J Oncol Nurs. 2008 Oct;12(5):759-66. doi: 10.1188/08.CJON.759-766. PMID: 18842532; PMCID: PMC2881685.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2881685/
343. Ranasinghe IR, Tian C, Hsu R. Crohn Disease. [Updated 2024 Feb 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK436021/
344. Lin, D., Jin, Y., Shao, X. et al. Global, regional, and national burden of inflammatory bowel disease, 1990–2021: Insights from the global burden of disease 2021. Int J Colorectal Dis 39, 139 (2024).https://doi.org/10.1007/s00384-024-04711-x
https://link.springer.com/article/10.1007/s00384-024-04711-x
345. Five Types of Crohn's Disease | North Shore Gastroenterology
https://www.northshoregastro.org/2020/10/16/five-types-of-crohns-disease/
346. Molodecky NA, Kaplan GG. Environmental risk factors for inflammatory bowel disease. Gastroenterol Hepatol (N Y). 2010 May;6(5):339-46. PMID: 20567592; PMCID: PMC2886488.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2886488/
347. Berkowitz L, Schultz BM, Salazar GA, Pardo-Roa C, Sebastián VP, Álvarez-Lobos MM and Bueno SM (2018) Impact of Cigarette Smoking on the Gastrointestinal Tract Inflammation: Opposing Effects in Crohn’s Disease and Ulcerative Colitis. Front. Immunol. 9:74. doi: 10.3389/fimmu.2018.00074
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.00074/full
348. What is Crohn's disease? A Mayo Clinic expert explains Learn more about Crohn's disease from gastroenterologist William Faubion, M.D., Oct. 29, 2024
https://www.mayoclinic.org/diseases-conditions/crohns-disease/symptoms-causes/syc-20353304
349. Last Reviewed July 2024, Diagnosis of Crohn’s Disease, the National Institute of Diabetes and Digestive and Kidney Diseases
https://www.niddk.nih.gov/health-information/digestive-diseases/crohns-disease/diagnosis
350. Bischoff SC, Escher J, Hébuterne X, Kłęk S, Krznaric Z, Schneider S, Shamir R, Stardelova K, Wierdsma N, Wiskin AE, Forbes A. ESPEN practical guideline: Clinical Nutrition in inflammatory bowel disease. Clin Nutr. 2020 Mar;39(3):632-653. doi: 10.1016/j.clnu.2019.11.002. Epub 2020 Jan 13. PMID: 32029281.
https://www.espen.org/files/ESPEN-Guidelines/ESPEN_practical_guideline_Clinical_Nutrition_in_inflammatory_bowel_disease.pdf
351. October 3, 2014 19 Μαίου Παγκόσμια Ημέρα ΙΦΝΕ Σύλλογος Ατόμων με Νόσο του Crohn και Ελκώδη Κολίτιδα Ελλάδας (HELLESCC)
https://crohnhellas.gr/19-maiou-pagkosmia-imera-ifne-2012/
352. Kumar B, Shah MAA, Kumari R, et al. Depression, Anxiety, and Stress Among Final-year Medical Students. Cureus. 2019 Mar;11(3):e4257. DOI: 10.7759/cureus.4257. PMID: 31139516; PMCID: PMC6519980.
https://europepmc.org/article/MED/31139516
353. Shamsuddin K, Fadzil F, Ismail WS, Shah SA, Omar K, Muhammad NA, Jaffar A, Ismail A, Mahadevan R. Correlates of depression, anxiety and stress among Malaysian university students. Asian J Psychiatr. 2013 Aug;6(4):318-23. doi: 10.1016/j.ajp.2013.01.014. Epub 2013 Mar 1. PMID: 23810140.
https://pubmed.ncbi.nlm.nih.gov/23810140/
354. Regehr C, Glancy D, Pitts A. Interventions to reduce stress in university students: a review and meta-analysis. J Affect Disord. 2013 May 15;148(1):1-11. doi: 10.1016/j.jad.2012.11.026. Epub 2012 Dec 13. PMID: 23246209.
https://pubmed.ncbi.nlm.nih.gov/23246209/
355. Lattie EG, Adkins EC, Winquist N, et al. Digital Mental Health Interventions for Depression, Anxiety, and Enhancement of Psychological Well-Being Among College Students: Systematic Review. Journal of Medical Internet Research. 2019 Jul;21(7):e12869. DOI: 10.2196/12869. PMID: 31333198; PMCID: PMC6681642.
https://europepmc.org/article/MED/31333198
356. Liu CH, Stevens C, Wong SHM, Yasui M, Chen JA. The prevalence and predictors of mental health diagnoses and suicide among U.S. college students: Implications for addressing disparities in service use. Depression and Anxiety. 2019 Jan;36(1):8-17. DOI: 10.1002/da.22830. PMID: 30188598; PMCID: PMC6628691.
https://europepmc.org/article/MED/30188598
357. Ebert DD, Franke M, Kählke F, et al. Increasing intentions to use mental health services among university students. Results of a pilot randomized controlled trial within the World Health Organization's World Mental Health International College Student Initiative. International Journal of Methods in Psychiatric Research. 2019 Jun;28(2):e1754. DOI: 10.1002/mpr.1754. PMID: 30456814; PMCID: PMC6877244.
https://europepmc.org/article/MED/30456814
358. González-Valero G, Zurita-Ortega F, Ubago-Jiménez JL, Puertas-Molero P. Use of Meditation and Cognitive Behavioral Therapies for the Treatment of Stress, Depression and Anxiety in Students. A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public Health. 2019 Nov;16(22):E4394. DOI: 10.3390/ijerph16224394. PMID: 31717682; PMCID: PMC6888319.
https://europepmc.org/article/MED/31717682
359. Davies EB, Morriss R, Glazebrook C. Computer-delivered and web-based interventions to improve depression, anxiety, and psychological well-being of university students: a systematic review and meta-analysis. J Med Internet Res. 2014 May 16;16(5):e130. doi: 10.2196/jmir.3142. PMID: 24836465; PMCID: PMC4051748.
https://pubmed.ncbi.nlm.nih.gov/24836465/
360. Matar Boumosleh J, Jaalouk D. Depression, anxiety, and smartphone addiction in university students- A cross sectional study. PLoS One. 2017 Aug 4;12(8):e0182239. doi: 10.1371/journal.pone.0182239. PMID: 28777828; PMCID: PMC5544206.
https://pubmed.ncbi.nlm.nih.gov/28777828/
361. Latas M, Pantić M, Obradović D. [Analysis of test anxiety in medical students]. Medicinski Pregled. 2010 Nov-Dec;63(11-12):863-866. DOI: 10.2298/mpns1012863l. PMID: 21553469.
http://europepmc.org/article/MED/21553469
362. Dikmen M. Test anxiety in online exams: scale development and validity. Current Psychology (New Brunswick, N.J.). 2022 Dec:1-13. DOI: 10.1007/s12144-022-04072-0. PMID: 36474484; PMCID: PMC9715417.
https://europepmc.org/article/MED/36474484
363. Lewis JE, Poles J, Shaw DP, et al. The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. Journal of Clinical and Translational Research. 2021 Aug;7(4):575-620. PMID: 34541370; PMCID: PMC8445631.
https://europepmc.org/article/MED/34541370
364. Iqbal AM, Jamal SF. Essential Hypertension. [Updated 2023 Jul 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK539859/
365. Essential hypertension, 08 Jan 2025, BMJ Best Practice
https://bestpractice.bmj.com/topics/en-gb/26
366. Chen S. Essential hypertension: perspectives and future directions. J Hypertens. 2012 Jan;30(1):42-5. doi: 10.1097/HJH.0b013e32834ee23c. PMID: 22157586; PMCID: PMC4152852.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4152852/
367. Carthy ER. Autonomic dysfunction in essential hypertension: A systematic review. Ann Med Surg (Lond). 2013 Dec 11;3(1):2-7. doi: 10.1016/j.amsu.2013.11.002. PMID: 25568776; PMCID: PMC4268473.
https://www.sciencedirect.com/science/article/pii/S2049080113000034
368. Verdecchia P, Schillaci G, Borgioni C, Ciucci A, Zampi I, Battistelli M, Gattobigio R, Sacchi N, Porcellati C. Cigarette smoking, ambulatory blood pressure and cardiac hypertrophy in essential hypertension. J Hypertens. 1995 Oct;13(10):1209-15. doi: 10.1097/00004872-199510000-00016. PMID: 8586813.
https://pubmed.ncbi.nlm.nih.gov/8586813/
369. Primary Hypertension (Formerly Known as Essential Hypertension), Last reviewed on 10/26/2021.
https://my.clevelandclinic.org/health/diseases/22024-primary-hypertension-formerly-known-as-essential-hypertension
370. Nouruzi S, Vasheghani Farahani A, Rezaeizadeh H, Ghafouri P, Ghorashi SM, Omidi N. Platelet Aggregation Inhibition: An Evidence-Based Systematic Review on the Role of Herbs for Primary Prevention Based on Randomized Controlled Trials. Iran J Med Sci. 2022 Nov;47(6):505-516. doi: 10.30476/IJMS.2021.91328.2247. PMID: 36380973; PMCID: PMC9652499.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9652499/
371. Wascher TC, Saely CH; den Ausschuss Leitlinien. Thrombozytenaggregationshemmer (Update 2019) [Inhibition of platelet aggregation (Update 2019)]. Wien Klin Wochenschr. 2019 May;131(Suppl 1):139-140. German. doi: 10.1007/s00508-018-1437-6. PMID: 30980156.
https://pubmed.ncbi.nlm.nih.gov/30980156/
372. Roy, S., Paul, K. Nourishing the clot: a comprehensive review of dietary habits and their implications for platelet function. Bull Fac Phys Ther 29, 7 (2024). https://doi.org/10.1186/s43161-023-00173-4
https://bfpt.springeropen.com/articles/10.1186/s43161-023-00173-4
373. Duttaroy, A.K. Functional Foods in Preventing Human Blood Platelet Hyperactivity-Mediated Diseases—An Updated Review. Nutrients 2024, 16, 3717. https://doi.org/10.3390/nu16213717
https://www.mdpi.com/2072-6643/16/21/3717
374. Yoshimoto, H.; Miyazawa, N.; Eguchi, F. Wild and Cultivated Mushrooms Exhibit Anti-Inflammatory Effects Including Inhibition of Platelet Aggregation and Interleukin-8 Expression. Appl. Microbiol. 2025, 5, 36. https://doi.org/10.3390/applmicrobiol5020036
https://www.mdpi.com/2673-8007/5/2/36
375. Purcell LK; Canadian Paediatric Society, Paediatric Sports and Exercise Medicine Section. Sport nutrition for young athletes. Paediatr Child Health. 2013 Apr;18(4):200-5. doi: 10.1093/pch/18.4.200. PMID: 24421690; PMCID: PMC3805623.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3805623/
376. Maughan RJ, Depiesse F, Geyer H; International Association of Athletics Federations. The use of dietary supplements by athletes. J Sports Sci. 2007;25 Suppl 1:S103-13. doi: 10.1080/02640410701607395. Erratum in: J Sports Sci. 2009 Apr;27(6):667. PMID: 18049988.
https://pubmed.ncbi.nlm.nih.gov/18049988/
377. Yuping Zhu, Gang Song, Molecular origin and biological effects of exercise mimetics, Journal of Exercise Science & Fitness, Volume 22, Issue 1, 2024, Pages 73-85, ISSN 1728-869X, https://doi.org/10.1016/j.jesf.2023.12.002.
https://www.sciencedirect.com/science/article/pii/S1728869X23000643
378. Giacomello, E.; Nicoletti, C.; Canato, M.; Toniolo, L. Exercise Mimetics in Aging: Suggestions from a Systematic Review. Nutrients 2025, 17, 969. https://doi.org/10.3390/nu17060969
https://www.mdpi.com/2072-6643/17/6/969
379. Gubert C, Hannan AJ. Exercise mimetics: harnessing the therapeutic effects of physical activity. Nat Rev Drug Discov. 2021 Nov;20(11):862-879. doi: 10.1038/s41573-021-00217-1. Epub 2021 Jun 8. PMID: 34103713.
https://pubmed.ncbi.nlm.nih.gov/34103713/
380. Vedant Samant, Arati Prabhu, Exercise, exerkines and exercise mimetic drugs: Molecular mechanisms and therapeutics, Life Sciences, Volume 359, 2024, 123225, ISSN 0024-3205, https://doi.org/10.1016/j.lfs.2024.123225.
https://www.sciencedirect.com/science/article/abs/pii/S0024320524008154
381. Li, S. and Laher, I. (2017), Exercise Mimetics: Running Without a Road Map. Clin. Pharmacol. Ther., 101: 188-190. https://doi.org/10.1002/cpt.533
https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.533
382. Cento, A.S., Leigheb, M., Caretti, G. et al. Exercise and Exercise Mimetics for the Treatment of Musculoskeletal Disorders. Curr Osteoporos Rep 20, 249–259 (2022). https://doi.org/10.1007/s11914-022-00739-6
https://link.springer.com/article/10.1007/s11914-022-00739-6
383. Fan W, Evans RM. Exercise Mimetics: Impact on Health and Performance. Cell Metab. 2017 Feb 7;25(2):242-247. doi: 10.1016/j.cmet.2016.10.022. Epub 2016 Nov 23. PMID: 27889389; PMCID: PMC5555683.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5555683/
384. Zhao, R. Exercise mimetics: a novel strategy to combat neuroinflammation and Alzheimer’s disease. J Neuroinflammation 21, 40 (2024). https://doi.org/10.1186/s12974-024-03031-9
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-024-03031-9
385. Silver MD. Use of ergogenic aids by athletes. J Am Acad Orthop Surg. 2001 Jan-Feb;9(1):61-70. doi: 10.5435/00124635-200101000-00007. PMID: 11174164.
https://pubmed.ncbi.nlm.nih.gov/11174164/
386. Varillas-Delgado, D. Nutritional Status and Ergogenic Aids in Performance During Exercise and Sports. Nutrients 2025, 17, 1224. https://doi.org/10.3390/nu17071224
https://www.mdpi.com/2072-6643/17/7/1224
387. Thein LA, Thein JM, Landry GL. Ergogenic aids. Phys Ther. 1995 May;75(5):426-39. doi: 10.1093/ptj/75.5.426. PMID: 7732086.
https://pubmed.ncbi.nlm.nih.gov/7732086/
388. Institute of Medicine (US) Committee on Military Nutrition Research; Marriott BM, editor. Food Components to Enhance Performance: An Evaluation of Potential Performance-Enhancing Food Components for Operational Rations. Washington (DC): National Academies Press (US); 1994. 12, Food Components That May Optimize Physical Performance: An Overview.
https://www.ncbi.nlm.nih.gov/books/NBK209034/
389. Ketterly J. Sports Medicine: Ergogenic Aids. FP Essent. 2022 Jul;518:23-28. PMID: 35830325.
https://pubmed.ncbi.nlm.nih.gov/35830325/
390. Maughan RJ. Nutritional ergogenic aids and exercise performance. Nutr Res Rev. 1999 Dec;12(2):255-80. doi: 10.1079/095442299108728956. PMID: 19087454.
https://pubmed.ncbi.nlm.nih.gov/19087454/
391. Wickham KA, Spriet LL. Food for thought: Physiological considerations for nutritional ergogenic efficacy. Scand J Med Sci Sports. 2024; 34:e14307. doi:10.1111/sms.14307
https://onlinelibrary.wiley.com/doi/10.1111/sms.14307
392. Ahrendt DM. Ergogenic aids: counseling the athlete. Am Fam Physician. 2001 Mar 1;63(5):913-22. PMID: 11261867.
https://www.aafp.org/pubs/afp/issues/2001/0301/p913.html
393. Chelladurai, Packianathan. (2008). Athletics IS Education: A Response to Kane, Leo, and Holleran’s (2008) Case Study of University of Minnesota Student-Athletes. Journal of Intercollegiate Sport. 1. 130-138. 10.1123/jis.1.1.130.
https://www.researchgate.net/publication/306054098_Athletics_IS_Education_A_Response_to_Kane_Leo_and_Holleran's_2008_Case_Study_of_University_of_Minnesota_Student-Athletes
394. Forbes SC, Best R and Dominguez R (2024) Editorial: Dietary supplements and ergogenic aids in relation to health and performance. Front. Sports Act. Living 6:1450604. doi: 10.3389/fspor.2024.1450604
https://www.frontiersin.org/journals/sports-and-active-living/articles/10.3389/fspor.2024.1450604/full
395. Dunn J, Grider MH. Physiology, Adenosine Triphosphate. [Updated 2023 Feb 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK553175/
https://www.ncbi.nlm.nih.gov/books/NBK553175/
396. Ralf Jäger, Martin Purpura, John A. Rathmacher, John C. Fuller, Lisa M. Pitchford, Fabricio E. Rossi, Chad M. Kerksick, Health and ergogenic potential of oral adenosine-5′-triphosphate (ATP) supplementation, Journal of Functional Foods, Volume 78, 2021, 104357, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2021.104357.
https://www.sciencedirect.com/science/article/pii/S1756464621000062
397. Morgan A. O'Brien, Derek G. Power, A. James P. Clover, Brian Bird, Declan M. Soden, Patrick F. Forde, Local tumour ablative therapies: Opportunities for maximising immune engagement and activation, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1846, Issue 2, 2014, Pages 510-523, ISSN 0304-419X, https://doi.org/10.1016/j.bbcan.2014.09.005.
https://www.sciencedirect.com/science/article/pii/S0304419X14000870
398. Greiner, J.V.; Glonek, T. Adenosine Triphosphate (ATP) and Protein Aggregation in Age-Related Vision-Threatening Ocular Diseases. Metabolites 2023, 13, 1100. https://doi.org/10.3390/metabo13101100
https://www.mdpi.com/2218-1989/13/10/1100
399. Jensen J, Rustad PI, Kolnes AJ, Lai YC. The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise. Front Physiol. 2011 Dec 30;2:112. doi: 10.3389/fphys.2011.00112. PMID: 22232606; PMCID: PMC3248697.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3248697/
400. Knuiman, P., Hopman, M.T.E. & Mensink, M. Glycogen availability and skeletal muscle adaptations with endurance and resistance exercise. Nutr Metab (Lond) 12, 59 (2015). https://doi.org/10.1186/s12986-015-0055-9
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-015-0055-9
401. Iliana López-Soldado, Joan J. Guinovart, Jordi Duran, Increased liver glycogen levels enhance exercise capacity in mice, Journal of Biological Chemistry, Volume 297, Issue 2, 2021, 100976, ISSN 0021-9258, https://doi.org/10.1016/j.jbc.2021.100976.
https://www.sciencedirect.com/science/article/pii/S002192582100778X
402. Ørtenblad N, Westerblad H, Nielsen J. Muscle glycogen stores and fatigue. J Physiol. 2013 Sep 15;591(18):4405-13. doi: 10.1113/jphysiol.2013.251629. Epub 2013 May 7. PMID: 23652590; PMCID: PMC3784189.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3784189/
403. Yun-tao Ma, CHAPTER 5 - Overtraining Syndrome and the Use of Muscle in Exercise, Editor(s): Yun-tao Ma, Acupuncture for Sports and Trauma Rehabilitation, Churchill Livingstone, 2011, Pages 36-48, ISBN 9781437709278, https://doi.org/10.1016/B978-1-4377-0927-8.00005-1.
https://www.sciencedirect.com/topics/immunology-and-microbiology/muscle-fatigue
404. W.W. Hay, GROWTH AND DEVELOPMENT, PHYSIOLOGICAL ASPECTS, Editor(s): Benjamin Caballero, Encyclopedia of Human Nutrition (Second Edition), Elsevier, 2005, Pages 423-433, ISBN 9780122266942, https://doi.org/10.1016/B0-12-226694-3/00156-3.
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/glycogen-liver-level
405. Glycogen, Last reviewed on 07/13/2022. Cleveland Clinic
https://my.clevelandclinic.org/health/articles/23509-glycogen
406. Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton SB, Brand-Miller J. Acne vulgaris: a disease of Western civilization. Arch Dermatol. 2002 Dec;138(12):1584-90. doi: 10.1001/archderm.138.12.1584. PMID: 12472346.
https://pubmed.ncbi.nlm.nih.gov/12472346/
407. Matsui MS. Update on diet and acne. Cutis. 2019 Jul;104(1):11-13. PMID: 31487341.
https://cdn.mdedge.com/files/s3fs-public/CT104001011.PDF
408. J Am Acad Dermatol. 2016 May;74(5):945-73.e33. doi: 10.1016/j.jaad.2015.12.037. Epub 2016 Feb 17. Guidelines of Care for the Management of Acne Vulgaris Andrea L Zaenglein, Arun L Pathy, Bethanee J Schlosser, Ali Alikhan, Hilary E Baldwin, Diane S Berson, Whitney P Bowe, Emmy M Graber, Julie C Harper, Sewon Kang, Jonette E Keri, James J Leyden, Rachel V Reynolds, Nanette B Silverberg, Linda F Stein Gold, Megha M Tollefson, Jonathan S Weiss, Nancy C Dolan, Andrew A Sagan, Mackenzie Stern, Kevin M Boyer, Reva Bhushan
https://pubmed.ncbi.nlm.nih.gov/26897386
409. Am Fam Physician. 2019 Oct 15;100(8):475-484. Acne Vulgaris: Diagnosis and Treatment Linda K Oge', Alan Broussard, Marilyn D Marshall
https://pubmed.ncbi.nlm.nih.gov/31613567
410. Br J Dermatol. 2015 Jul;172 Suppl 1:3-12. doi: 10.1111/bjd.13462. A Global Perspective on the Epidemiology of Acne J K L Tan, K Bhate
https://pubmed.ncbi.nlm.nih.gov/25597339
411. Eur J Dermatol . 2017 Aug 1;27(4):393-398. doi: 10.1684/ejd.2017.3062. Adult Female Acne Treated With Spironolactone: A Retrospective Data Review of 70 Cases Anne Isvy-Joubert, Jean-Michel Nguyen, Aurélie Gaultier, Mélanie Saint-Jean, Marie Le Moigne, Elodie Boisrobert, Amir Khammari, Brigitte Dreno
https://pubmed.ncbi.nlm.nih.gov/28862134
412. Acta Derm Venereol . 2013 Nov;93(6):644-9. doi: 10.2340/00015555-1677. Acne: Risk Indicator for Increased Body Mass Index and Insulin Resistance Bodo C Melnik 1 , Swen Malte John, Gerd Plewig
https://pubmed.ncbi.nlm.nih.gov/23975508/
https://www.researchgate.net/publication/256102062_Acne_Risk_Indicator_for_Increased_Body_Mass_Index_and_Insulin_Resistance
413.Cochrane Database Syst Rev. 2018 Nov 24;11(11):CD009435. doi: 10.1002/14651858.CD009435.pub2. Oral Isotretinoin for Acne Caroline S Costa , Ediléia Bagatin, Ana Luiza C Martimbianco, Edina Mk da Silva, Marília M Lúcio, Parker Magin, Rachel Riera
https://pubmed.ncbi.nlm.nih.gov/30484286
414. Am J Clin Dermatol. 2017 Jun;18(3):311-321. doi: 10.1007/s40257-017-0255-3. The Role of Photodynamic Therapy in Acne: An Evidence-Based Review Monica Boen, Joshua Brownell, Priyanka Patel, Maria M Tsoukas
https://pubmed.ncbi.nlm.nih.gov/28276005
415. Wiad Lek. 2018;71(1 pt 2):144-147. Indicators of Phagocytosis in Women With Acne During Comprehensive Treatment That Included Immunotherapy and Probiotics Orysya О Syzon, Marianna О Dashko
https://pubmed.ncbi.nlm.nih.gov/29602922
416. Cochrane Database Syst Rev. 2016 Apr 3;4(4):CD011946. doi: 10.1002/14651858.CD011946.pub2. Interventions for Acne Scars Rania Abdel Hay, Khalid Shalaby, Hesham Zaher, Vanessa Hafez, Ching-Chi Chi, Sandra Dimitri, Ashraf F Nabhan, Alison M Layton
https://pubmed.ncbi.nlm.nih.gov/27038134
417. Wu, Y.; Choi, M.-H.; Li, J.; Yang, H.; Shin, H.-J. Mushroom Cosmetics: The Present and Future. Cosmetics 2016, 3, 22. https://doi.org/10.3390/cosmetics3030022
https://www.mdpi.com/2079-9284/3/3/22
418. Εθελοντική Αιμοδοσία για την κάλυψη των αναγκών της Ογκολογικής Μονάδας Παίδων Μαριάννα Β. Βαρδινογιάννη “Ελπίδα”. Ελληνική Εταιρεία Μαστολογίας
https://mastologia.gr/news/167-ethelontiki-aimodosia-gia-tin-kalypsi-ton-anagkon-tis-ogkologikis-monadas-paidon-marianna-v-vardinogianni-elpida
419. Salonen JT, Tuomainen TP, Salonen R, Lakka TA, Nyyssönen K. Donation of blood is associated with reduced risk of myocardial infarction. The Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Epidemiol. 1998 Sep 1;148(5):445-51. doi: 10.1093/oxfordjournals.aje.a009669. PMID: 9737556.
https://pubmed.ncbi.nlm.nih.gov/9737556/
420. Donating blood benefits both recipients and donors, Tayla Holman January 01, 2024, HCA Houston Healthcare
https://www.hcahoustonhealthcare.com/healthy-living/blog/donating-blood-benefits-both-recipients-and-donors
421. Leo R. Zacharski, Bruce K. Chow, Paula S. Howes, Galina Shamayeva, John A. Baron, Ronald L. Dalman, David J. Malenka, C. Keith Ozaki, Philip W. Lavori, Decreased Cancer Risk After Iron Reduction in Patients With Peripheral Arterial Disease: Results From a Randomized Trial, JNCI: Journal of the National Cancer Institute, Volume 100, Issue 14, 16 July 2008, Pages 996–1002, https://doi.org/10.1093/jnci/djn209
https://academic.oup.com/jnci/article-abstract/100/14/996/917996?redirectedFrom=fulltext&login=false
422. Torti SV, Manz DH, Paul BT, Blanchette-Farra N, Torti FM. Iron and Cancer. Annu Rev Nutr. 2018 Aug 21;38:97-125. doi: 10.1146/annurev-nutr-082117-051732. PMID: 30130469; PMCID: PMC8118195.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8118195/
423. Constipation, The Johns Hopkins University
https://www.hopkinsmedicine.org/health/conditions-and-diseases/constipation
424. Complications of Constipation, Stanford Health
https://stanfordhealthcare.org/medical-conditions/primary-care/constipation/complications.html
425. Sundbøll J, Szépligeti SK, Adelborg K, et al Constipation and risk of cardiovascular diseases: a Danish population-based matched cohort study BMJ Open 2020;10:e037080. doi: 10.1136/bmjopen-2020-037080
https://bmjopen.bmj.com/content/10/9/e037080
426. PRESS RELEASE Constipation Associated with Cognitive Aging and Decline Plus, Gut Bacteria Linked to Alzheimer’s Biomarkers, Dementia Risk, Alzheimer’s Association
https://aaic.alz.org/releases_2023/constipation-gut-health-alzheimers-dementia-risk.asp
427. Constipation and faecal impaction, Alzheimer Scotland
https://www.alzscot.org/our-work/dementia-support/information-sheets/constipation-and-faecal-impaction
428. Incontinence and constipation, Alzheimers New Zealand
https://alzheimers.org.nz/get-support/supporting-someone-with-dementia/incontinence-and-constipation/
429. Chen CL, Liang TM, Chen HH, Lee YY, Chuang YC, Chen NC. Constipation and Its Associated Factors among Patients with Dementia. Int J Environ Res Public Health. 2020 Dec 3;17(23):9006. doi: 10.3390/ijerph17239006. PMID: 33287267; PMCID: PMC7730313.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730313/
430. Editorial| Volume 4, ISSUE 11, P811, November 2019, The cost of constipation The Lancet Gastroenterology & Hepatology Published:November, 2019DOI:https://doi.org/10.1016/S2468-1253(19)30297-3
https://www.thelancet.com/journals/langas/article/PIIS2468-1253(19)30297-3/fulltext
431. Bellini, M.; Tonarelli, S.; Barracca, F.; Rettura, F.; Pancetti, A.; Ceccarelli, L.; Ricchiuti, A.; Costa, F.; de Bortoli, N.; Marchi, S.; et al. Chronic Constipation: Is a Nutritional Approach Reasonable? Nutrients 2021, 13, 3386. https://doi.org/10.3390/nu13103386
https://www.mdpi.com/2072-6643/13/10/3386
432. Multiple Sclerosis (MS), The Johns Hopkins University
https://www.hopkinsmedicine.org/health/conditions-and-diseases/multiple-sclerosis-ms
433. Tafti D, Ehsan M, Xixis KL. Multiple Sclerosis. [Updated 2024 Mar 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK499849/
434. Ford H. Clinical presentation and diagnosis of multiple sclerosis. Clin Med (Lond). 2020 Jul;20(4):380-383. doi: 10.7861/clinmed.2020-0292. PMID: 32675142; PMCID: PMC7385797.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7385797/
435. Walton C, King R, Rechtman L, Kaye W, Leray E, Marrie RA, Robertson N, La Rocca N, Uitdehaag B, van der Mei I, Wallin M, Helme A, Angood Napier C, Rijke N, Baneke P. Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition. Mult Scler. 2020 Dec;26(14):1816-1821. doi: 10.1177/1352458520970841. Epub 2020 Nov 11. PMID: 33174475; PMCID: PMC7720355.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7720355/
436. Emilio Portaccio, Melinda Magyari, Eva Kubala Havrdova, Aurelie Ruet, Bruno Brochet, Antonio Scalfari, Massimiliano Di Filippo, Carmen Tur, Xavier Montalban, Maria Pia Amato, Multiple sclerosis: emerging epidemiological trends and redefining the clinical course, The Lancet Regional Health - Europe, Volume 44, 2024, 100977, ISSN 2666-7762, https://doi.org/10.1016/j.lanepe.2024.100977.
https://www.sciencedirect.com/science/article/pii/S2666776224001443
437. Wingerchuk DM. Smoking: effects on multiple sclerosis susceptibility and disease progression. Ther Adv Neurol Disord. 2012 Jan;5(1):13-22. doi: 10.1177/1756285611425694. PMID: 22276073; PMCID: PMC3251901.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3251901/
438. Nishanth K, Tariq E, Nzvere FP, Miqdad M, Cancarevic I. Role of Smoking in the Pathogenesis of Multiple Sclerosis: A Review Article. Cureus. 2020 Aug 5;12(8):e9564. doi: 10.7759/cureus.9564. PMID: 32905534; PMCID: PMC7473606.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7473606/
439. Borros Arneth, Multiple Sclerosis and Smoking, The American Journal of Medicine, Volume 133, Issue 7, 2020, Pages 783-788, ISSN 0002-9343, https://doi.org/10.1016/j.amjmed.2020.03.008.
https://www.sciencedirect.com/science/article/abs/pii/S000293432030228X
440. Manouchehrinia A, Huang J, Hillert J, Alfredsson L, Olsson T, Kockum I and Constantinescu CS (2022) Smoking Attributable Risk in Multiple Sclerosis. Front. Immunol. 13:840158. doi: 10.3389/fimmu.2022.840158
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.840158/full
441. Demyelination: Demyelinating diseases and symptoms Last updated May 27, 2022, by Marisa Wexler, MS Fact-checked by Patricia Silva, PhD
https://multiplesclerosisnewstoday.com/demyelination/
442. Demyelinating disease: What can you do about it?, Eoin P. Flanagan, M.B., B.Ch.
https://www.mayoclinic.org/diseases-conditions/multiple-sclerosis/expert-answers/demyelinating-disease/faq-20058521?
443. Demyelinating Disease, Cleveland Clinic, 10/18/2023
https://my.clevelandclinic.org/health/diseases/demyelinating-disease
444. Signs & Symptoms Consistent with Demyelinating Disease, The National Multiple Sclerosis Society,
https://www.nationalmssociety.org/for-professionals/for-healthcare-professionals/diagnosing-ms/demyelinating-disease
445. Shields DC, Schaecher KE, Saido TC, Banik NL. A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11486-91. doi: 10.1073/pnas.96.20.11486. PMID: 10500203; PMCID: PMC18060.
https://www.pnas.org/doi/full/10.1073/pnas.96.20.11486
446. Aditya G. Shivane, Arundhati Chakrabarty, Multiple sclerosis and demyelination, Current Diagnostic Pathology, Volume 13, Issue 3, 2007, Pages 193-202, ISSN 0968-6053, https://doi.org/10.1016/j.cdip.2007.04.003.
447. Lubetzki C, Stankoff B. Demyelination in multiple sclerosis. Handb Clin Neurol. 2014;122:89-99. doi: 10.1016/B978-0-444-52001-2.00004-2. PMID: 24507514; PMCID: PMC7152443.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152443/
448. Zhao X, Jacob C. Mechanisms of Demyelination and Remyelination Strategies for Multiple Sclerosis. Int J Mol Sci. 2023 Mar 28;24(7):6373. doi: 10.3390/ijms24076373. PMID: 37047344; PMCID: PMC10093908.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093908/
449. Lucchinetti CF, Popescu BF, Bunyan RF, Moll NM, Roemer SF, Lassmann H, Brück W, Parisi JE, Scheithauer BW, Giannini C, Weigand SD, Mandrekar J, Ransohoff RM. Inflammatory cortical demyelination in early multiple sclerosis. N Engl J Med. 2011 Dec 8;365(23):2188-97. doi: 10.1056/NEJMoa1100648. PMID: 22150037; PMCID: PMC3282172.
https://www.nejm.org/doi/full/10.1056/NEJMoa1100648
450. What Are Demyelinating Diseases? Medically Reviewed by Christopher Melinosky, MD on September 06, 2022 Written by Rachel Reiff Ellis, WebMD LLC
https://www.webmd.com/multiple-sclerosis/what-are-demyelinating-disorders
451. Demyelination: What Is It and Why Does It Happen?, Medically reviewed by Heidi Moawad, M.D. — Written by The Healthline Editorial Team on March 27, 2014
https://www.healthline.com/health/multiple-sclerosis/demyelination
452. What to Know About Demyelination, the Driving Force of Multiple Sclerosis, By Sara Gaynes LevyMedically reviewed by Mia Tova Minen, MD, MPH March 7, 2022
https://www.self.com/story/demyelination-and-ms
453. Haider L, Simeonidou C, Steinberger G, et al Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron Journal of Neurology, Neurosurgery & Psychiatry 2014;85:1386-1395.
https://jnnp.bmj.com/content/85/12/1386
454. hematocrit, National Cancer Institute at the National Institutes of Health
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/hematocrit
455. Mondal H, Zubair M. Hematocrit. [Updated 2024 Oct 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK542276/
456. Billett HH. Hemoglobin and Hematocrit. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Boston: Butterworths; 1990. Chapter 151.
https://www.ncbi.nlm.nih.gov/books/NBK259/
457. Turner J, Parsi M, Badireddy M. Anemia. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK499994/
458. F.G. Huffman, S. Nath, Z.C. Shah, ANEMIA (ANAEMIA) | Other Nutritional Causes, Editor(s): Benjamin Caballero, Encyclopedia of Food Sciences and Nutrition (Second Edition), Academic Press, 2003, Pages 226-232, ISBN 9780122270550, https://doi.org/10.1016/B0-12-227055-X/00043-2.
https://www.sciencedirect.com/topics/veterinary-science-and-veterinary-medicine/nutritional-anemia
459. Killeen RB, Kaur A, Afzal M. Acute Anemia. [Updated 2025 Feb 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537232/
460. Stevens GA, Paciorek CJ, Flores-Urrutia MC, Borghi E, Namaste S, Wirth JP, Suchdev PS, Ezzati M, Rohner F, Flaxman SR, Rogers LM. National, regional, and global estimates of anaemia by severity in women and children for 2000-19: a pooled analysis of population-representative data. Lancet Glob Health. 2022 May;10(5):e627-e639. doi: 10.1016/S2214-109X(22)00084-5. PMID: 35427520; PMCID: PMC9023869.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9023869/
461. Malenica M, Prnjavorac B, Bego T, Dujic T, Semiz S, Skrbo S, Gusic A, Hadzic A, Causevic A. Effect of Cigarette Smoking on Haematological Parameters in Healthy Population. Med Arch. 2017 Apr;71(2):132-136. doi: 10.5455/medarh.2017.71.132-136. PMID: 28790546; PMCID: PMC5511531.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5511531/
462. Vitak T, Yurkiv B, Wasser S, Nevo E, Sybirna N. Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus. World J Diabetes. 2017 May 15;8(5):187-201. doi: 10.4239/wjd.v8.i5.187. PMID: 28572880; PMCID: PMC5437617.
https://pubmed.ncbi.nlm.nih.gov/28572880/
463. Teja KS, Suruchi, Rai U, Kumar M, Mohanty O, Roy J, Meshram S. Mushrooms: A Potential Option in the Management of Deficiency and Diseases in Humans. J Pure Appl Microbiol. 2023;17(2):749-760. doi: 10.22207/JPAM.17.2.55
https://microbiologyjournal.org/mushrooms-a-potential-option-in-the-management-of-deficiency-and-diseases-in-humans/
464. Shukla A, Rasquin LI, Anastasopoulou C. Polycystic Ovarian Syndrome. [Updated 2025 May 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459251/
465. Bohsas, H., Alibrahim, H., Swed, S., Abouainain, Y., Aljabali, A., Kazan, L., … Khandaker, M. U. (2024). Prevalence and knowledge of polycystic ovary syndrome (PCOS) and health-related practices among women of Syria: a cross-sectional study. Journal of Psychosomatic Obstetrics & Gynecology, 45(1). https://doi.org/10.1080/0167482X.2024.2318194
https://www.tandfonline.com/doi/full/10.1080/0167482X.2024.2318194#abstract
466. Deswal R, Narwal V, Dang A, Pundir CS. The Prevalence of Polycystic Ovary Syndrome: A Brief Systematic Review. J Hum Reprod Sci. 2020 Oct-Dec;13(4):261-271. doi: 10.4103/jhrs.JHRS_95_18. Epub 2020 Dec 28. PMID: 33627974; PMCID: PMC7879843.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7879843/
467. Singh S, Pal N, Shubham S, Sarma DK, Verma V, Marotta F, Kumar M. Polycystic Ovary Syndrome: Etiology, Current Management, and Future Therapeutics. J Clin Med. 2023 Feb 11;12(4):1454. doi: 10.3390/jcm12041454. PMID: 36835989; PMCID: PMC9964744.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9964744/
468. Johnson JE, Daley D, Tarta C, Stanciu PI. Risk of endometrial cancer in patients with polycystic ovarian syndrome: A meta‑analysis. Oncol Lett. 2023 Mar 8;25(4):168. doi: 10.3892/ol.2023.13754. PMID: 36960190; PMCID: PMC10028221.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10028221/
469. Liao WT, Huang JY, Lee MT, Yang YC, Wu CC. Higher risk of type 2 diabetes in young women with polycystic ovary syndrome: A 10-year retrospective cohort study. World J Diabetes. 2022 Mar 15;13(3):240-250. doi: 10.4239/wjd.v13.i3.240. PMID: 35432752; PMCID: PMC8984565.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8984565/
470. Yasmin A, Roychoudhury S, Paul Choudhury A, Ahmed ABF, Dutta S, Mottola F, Verma V, Kalita JC, Kumar D, Sengupta P, Kolesarova A. Polycystic Ovary Syndrome: An Updated Overview Foregrounding Impacts of Ethnicities and Geographic Variations. Life (Basel). 2022 Nov 25;12(12):1974. doi: 10.3390/life12121974. PMID: 36556340; PMCID: PMC9785838.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9785838/
471. Cupisti S, Häberle L, Dittrich R, Oppelt PG, Reissmann C, Kronawitter D, Beckmann MW, Mueller A. Smoking is associated with increased free testosterone and fasting insulin levels in women with polycystic ovary syndrome, resulting in aggravated insulin resistance. Fertil Steril. 2010 Jul;94(2):673-7. doi: 0.1016/j.fertnstert.2009.03.062. Epub 2009 Apr 25. PMID: 19394003.
https://pubmed.ncbi.nlm.nih.gov/19394003/
472. Yang, Y., Zhang, H., Huang, BY. et al. Relationship between smoking, excessive androgen and negative emotions in women with polycystic ovary syndrome (PCOS). J Ovarian Res 17, 211 (2024). https://doi.org/10.1186/s13048-024-01541-x
https://ovarianresearch.biomedcentral.com/articles/10.1186/s13048-024-01541-x
473. Dason ES, Koshkina O, Chan C, Sobel M. Diagnosis and management of polycystic ovarian syndrome. CMAJ. 2024 Jan 28;196(3):E85-E94. doi: 10.1503/cmaj.231251. Erratum in: CMAJ. 2024 Mar 3;196(8):E269. doi: 10.1503/cmaj.240216. Erratum in: CMAJ. 2024 Mar 17;196(10):E351. doi: 10.1503/cmaj.240303. PMID: 38286488; PMCID: PMC10833093.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10833093/
474. Nikokavoura EA, Johnston KL, Broom J, Wrieden WL, Rolland C. Weight loss for women with and without polycystic ovary syndrome following a very low-calorie diet in a community-based setting with trained facilitators for 12 weeks. Diabetes Metab Syndr Obes. 2015 Oct 14;8:495-503. doi: 10.2147/DMSO.S85134. PMID: 26508882; PMCID: PMC4610794.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4610794/
475. Szczuko M, Kikut J, Szczuko U, Szydłowska I, Nawrocka-Rutkowska J, Ziętek M, Verbanac D, Saso L. Nutrition Strategy and Life Style in Polycystic Ovary Syndrome-Narrative Review. Nutrients. 2021 Jul 18;13(7):2452. doi: 10.3390/nu13072452. PMID: 34371961; PMCID: PMC8308732.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8308732/
476. What is Long COVID and how is it treated, 9 May 2025, National Centre for Infectious Diseases
https://www.ncid.sg/News-Events/News/Pages/What-is-Long-COVID-and-how-is-it-treated.aspx
477. Alwan NA, Johnson L. Defining long COVID: Going back to the start. Med. 2021 May 14;2(5):501-504. doi: 10.1016/j.medj.2021.03.003. Epub 2021 Mar 25. PMID: 33786465; PMCID: PMC7992371.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7992371/
478. Al-Oraibi A, Woolf K, Naidu J, Nellums LB, Pan D, Sze S, Tarrant C, Martin CA, Gogoi M, Nazareth J, Divall P, Dempsey B, Lamb D, Pareek M. Global prevalence of long COVID and its most common symptoms among healthcare workers: a systematic review and meta-analysis. BMJ Public Health. 2025 Apr 17;3(1):e000269. doi: 10.1136/bmjph-2023-000269. PMID: 40260126; PMCID: PMC12010341.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12010341/
479. Global Prevalence of Long COVID, its Subtypes and Risk factors: An Updated Systematic Review and Meta-Analysis Yiren Hou, Tian Gu, Zhouchi Ni, Xu Shi, Megan L. Ranney, Bhramar Mukherjee medRxiv 2025.01.01.24319384; doi: https://doi.org/10.1101/2025.01.01.24319384
https://www.medrxiv.org/content/10.1101/2025.01.01.24319384v1.full
480. Lucas Etienne Hermans, Sean Wasserman, Lizhen Xu, John Eikelboom - Long COVID prevalence and risk factors in adults residing in middle- and high-income countries: secondary analysis of the multinational Anti-Coronavirus Therapies (ACT) trials: BMJ Global Health 2025;10:e017126.
https://gh.bmj.com/content/10/4/e017126
481. Hastie, C.E., Lowe, D.J., McAuley, A. et al. True prevalence of long-COVID in a nationwide, population cohort study. Nat Commun 14, 7892 (2023). https://doi.org/10.1038/s41467-023-43661-w
https://www.nature.com/articles/s41467-023-43661-w
482. Trofor AC, Robu Popa D, Melinte OE, Trofor L, Vicol C, Grosu-Creangă IA, Crișan Dabija RA, Cernomaz AT. Looking at the Data on Smoking and Post-COVID-19 Syndrome-A Literature Review. J Pers Med. 2024 Jan 16;14(1):97. doi: 10.3390/jpm14010097. PMID: 38248798; PMCID: PMC10821354.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10821354/
483. de Granda-Orive JI, Solano-Reina S, Jiménez-Ruiz CA. Are Smoking and Vaping Risk Factors of Developing Long and Persistent Post-COVID-19? Open Respir Arch. 2022 Jul 29;4(4):100195. doi: 10.1016/j.opresp.2022.100195. PMID: 37496961; PMCID: PMC9335855.
https://www.elsevier.es/en-revista-open-respiratory-archives-11-avance-resumen-are-smoking-vaping-risk-factors-S2659663622000418
484. Long-term effects of COVID-19 (long COVID), NHS UK, 21 March 2023
https://www.nhs.uk/conditions/covid-19/long-term-effects-of-covid-19-long-covid/
485. Seo JW, Kim SE, Kim Y, Kim EJ, Kim T, Kim T, Lee SH, Lee E, Lee J, Seo YB, Jeong YH, Jung YH, Choi YJ, Song JY. Updated Clinical Practice Guidelines for the Diagnosis and Management of Long COVID. Infect Chemother. 2024 Mar;56(1):122-157. doi: 10.3947/ic.2024.0024. Epub 2024 Mar 13. PMID: 38527781; PMCID: PMC10990882.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10990882/
486. Long Covid and diet, British Dietetic Association
https://www.bda.uk.com/resource/long-covid-and-diet.html
487. Guerra G, Lucariello A, Komici K. Editorial: Long COVID: nutrition and lifestyle changes. Front Nutr. 2024 Feb 21;11:1375449. doi: 10.3389/fnut.2024.1375449. PMID: 38450231; PMCID: PMC10915234.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10915234/
488. Booi, Han-Ni & Lee, mei k & Fung, Shin & Ng, Szuting & Tan, Chon-Seng & Lim, Kuan-Hon & Roberts, Richard & Ting, Kang. (2022). Medicinal Mushrooms and Their Use to Strengthen Respiratory Health During and Post-COVID-19 Pandemic. International Journal of Medicinal Mushrooms. 24. 10.1615/IntJMedMushrooms.2022045068.
https://www.researchgate.net/publication/362027865_Medicinal_Mushrooms_and_Their_Use_to_Strengthen_Respiratory_Health_During_and_Post-COVID-19_Pandemic
489. Slomski A. Trials Test Mushrooms and Herbs as Anti–COVID-19 Agents. JAMA. 2021;326(20):1997–1999. doi:10.1001/jama.2021.19388
https://jamanetwork.com/journals/jama/fullarticle/2786023
490. Phillips JM, Ooi SL, Pak SC. Health-Promoting Properties of Medicinal Mushrooms and Their Bioactive Compounds for the COVID-19 Era-An Appraisal: Do the Pro-Health Claims Measure Up? Molecules. 2022 Apr 1;27(7):2302. doi: 10.3390/molecules27072302. PMID: 35408701; PMCID: PMC9000601.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9000601/
491. Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan, Xuefei Yang, A concise review of mushrooms antiviral and immunomodulatory properties that may combat against COVID-19, Food Chemistry Advances, Volume 1, 2022, 100023, ISSN 2772-753X, https://doi.org/10.1016/j.focha.2022.100023.
https://www.sciencedirect.com/science/article/pii/S2772753X22000120
492. Hetland G, Johnson E, Bernardshaw SV, Grinde B. Can medicinal mushrooms have prophylactic or therapeutic effect against COVID-19 and its pneumonic superinfection and complicating inflammation? Scand J Immunol. 2021 Jan;93(1):e12937. doi: 10.1111/sji.12937. Epub 2020 Jul 29. PMID: 32657436; PMCID: PMC7404338.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7404338/
493. Chapter Medicinal Mushrooms as Nutritional Management for Post COVID-19 Syndromes ByNehal M. El-Deeb, Hesham Ali El Enshasy, Aya M. Fouad, Ahmed M. Kenawy Book Bioprospects of Macrofungi Edition 1st Edition First Published 2023
https://www.taylorfrancis.com/chapters/edit/10.1201/9781003343806-17/medicinal-mushrooms-nutritional-management-post-covid-19-syndromes-nehal-el-deeb-hesham-ali-el-enshasy-aya-fouad-ahmed-kenawy
494. Thiebaud, Robert. (2012). Exercise-Induced Muscle Damage: Is it detrimental or beneficial?. Journal of Trainology. 1. 36-44. 10.17338/trainology.1.2_36.
https://www.jstage.jst.go.jp/article/trainology/1/2/1_36/_article
495. Owens DJ, Twist C, Cobley JN, Howatson G, Close GL. Exercise-induced muscle damage: What is it, what causes it and what are the nutritional solutions? Eur J Sport Sci. 2019 Feb;19(1):71-85. doi: 10.1080/17461391.2018.1505957. Epub 2018 Aug 15. PMID: 30110239.
https://pubmed.ncbi.nlm.nih.gov/30110239/
496. Howatson G, van Someren KA. The prevention and treatment of exercise-induced muscle damage. Sports Med. 2008;38(6):483-503. doi: 10.2165/00007256-200838060-00004. PMID: 18489195.
https://pubmed.ncbi.nlm.nih.gov/18489195/
497. Harty, P.S., Cottet, M.L., Malloy, J.K. et al. Nutritional and Supplementation Strategies to Prevent and Attenuate Exercise-Induced Muscle Damage: a Brief Review. Sports Med - Open 5, 1 (2019). https://doi.org/10.1186/s40798-018-0176-6
https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-018-0176-6.
498. Leite, C.D.F.C.; Zovico, P.V.C.; Rica, R.L.; Barros, B.M.; Machado, A.F.; Evangelista, A.L.; Leite, R.D.; Barauna, V.G.; Maia, A.F.; Bocalini, D.S. Exercise-Induced Muscle Damage after a High-Intensity Interval Exercise Session: Systematic Review. Int. J. Environ. Res. Public Health 2023, 20, 7082. https://doi.org/10.3390/ijerph20227082
https://www.mdpi.com/1660-4601/20/22/7082
499. Sunbol, Khalid & Althiyabi, Fahad & Alshuria, Abdulaziz & Alajwad, Mahdi & Mahlawi, Amoudi & Alsayed, Budur & Alsarhan, Mustafa & Alshehri, Rahaf & Alsahli, Abdulaziz & Alhazmi, Khalid & Esmae, Emtenan. (2022). Etiology, risk factors and complications of exercise induced muscle injury. International Journal Of Community Medicine And Public Health. 10. 10.18203/2394-6040.ijcmph20223319.
https://www.researchgate.net/publication/366387424_Etiology_risk_factors_and_complications_of_exercise_induced_muscle_injury
500. Price TB, Krishnan-Sarin S, Rothman DL. Smoking impairs muscle recovery from exercise. Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E116-22. doi: 10.1152/ajpendo.00543.2002. Epub 2003 Mar 11. PMID: 12637259.
https://pubmed.ncbi.nlm.nih.gov/12637259/
501. İpekoğlu, Gökhan & Taskin, Halil & Şenel, Ömer. (2019). Examination of Exercise-Induced Skeletal and Cardiac Muscle Damage in Terms of Smoking. Montenegrin Journal of Sports Science & Medicine. 8. 10.26773/mjssm.190901.
https://www.researchgate.net/publication/332111862_Examination_of_Exercise-Induced_Skeletal_and_Cardiac_Muscle_Damage_in_Terms_of_Smoking
502. Xu, F.; Zeng, J.; Liu, X.; Lai, J.; Xu, J. Exercise-Induced Muscle Damage and Protein Intake: A Bibliometric and Visual Analysis. Nutrients 2022, 14, 4288. https://doi.org/10.3390/nu14204288
https://www.mdpi.com/2072-6643/14/20/4288
503. Glik A, Douvdevani A. T lymphocytes: the "cellular" arm of acquired immunity in the peritoneum. Perit Dial Int. 2006 Jul-Aug;26(4):438-48. PMID: 16881338.
https://pubmed.ncbi.nlm.nih.gov/16881338/
504. Sun, L., Su, Y., Jiao, A. et al. T cells in health and disease. Sig Transduct Target Ther 8, 235 (2023). https://doi.org/10.1038/s41392-023-01471-y
https://www.nature.com/articles/s41392-023-01471-y
505. Klimpel GR. Immune Defenses. In: Baron S, editor. Medical Microbiology. 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Chapter 50.
https://www.ncbi.nlm.nih.gov/books/NBK8423/
506. Anisha Singha Deo, Shrijana, Sruthika S.U, Shreya Karun, Kashish Bisaria, Koustav Sarkar, Participation of T cells in generating immune protection against cancers, Pathology - Research and Practice, Volume 262, 2024, 155534, ISSN 0344-0338, https://doi.org/10.1016/j.prp.2024.155534.
https://www.sciencedirect.com/science/article/abs/pii/S034403382400445X
507. Chen C, Liu X, Chang CY, Wang HY, Wang RF. The Interplay between T Cells and Cancer: The Basis of Immunotherapy. Genes (Basel). 2023 Apr 28;14(5):1008. doi: 10.3390/genes14051008. PMID: 37239368; PMCID: PMC10218245.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10218245/
508. Ruiz-Argüelles A. T lymphocytes in autoimmunity. In: Anaya JM, Shoenfeld Y, Rojas-Villarraga A, et al., editors. Autoimmunity: From Bench to Bedside [Internet]. Bogota (Colombia): El Rosario University Press; 2013 Jul 18. Chapter 7.
https://www.ncbi.nlm.nih.gov/books/NBK459477/
509. Janeway CA Jr, Travers P, Walport M, et al. Immunobiology: The Immune System in Health and Disease. 5th edition. New York: Garland Science; 2001. Generation of lymphocytes in bone marrow and thymus.
https://www.ncbi.nlm.nih.gov/books/NBK27123/
510. Kono M, Takagi Y, Kawauchi S, Wada A, Morikawa T, Funakoshi K. Non-activated T and B lymphocytes become morphologically distinguishable after detergent treatment. Cytometry A. 2013 Apr;83(4):396-402. doi: 10.1002/cyto.a.22262. Epub 2013 Feb 11. PMID: 23401265.
https://pubmed.ncbi.nlm.nih.gov/23401265/
511. Hernandez CP, Morrow K, Velasco C, Wyczechowska DD, Naura AS, Rodriguez PC. Effects of cigarette smoke extract on primary activated T cells. Cell Immunol. 2013 Mar;282(1):38-43. doi: 10.1016/j.cellimm.2013.04.005. Epub 2013 Apr 22. PMID: 23665673; PMCID: PMC3676722.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3676722/
512. Saint-André, V., Charbit, B., Biton, A. et al. Smoking changes adaptive immunity with persistent effects. Nature 626, 827–835 (2024). https://doi.org/10.1038/s41586-023-06968-8
https://www.nature.com/articles/s41586-023-06968-8
513. Collins N. Dietary Regulation of Memory T Cells. Int J Mol Sci. 2020 Jun 19;21(12):4363. doi: 10.3390/ijms21124363. PMID: 32575427; PMCID: PMC7352243.
https://pubmed.ncbi.nlm.nih.gov/32575427/
514. Cohen S, Danzaki K, MacIver NJ. Nutritional effects on T-cell immunometabolism. Eur J Immunol. 2017 Feb;47(2):225-235. doi: 10.1002/eji.201646423. Epub 2017 Jan 24. PMID: 28054344; PMCID: PMC5342627.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5342627/
515. Guggenheim AG, Wright KM, Zwickey HL. Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology. Integr Med (Encinitas). 2014 Feb;13(1):32-44. PMID: 26770080; PMCID: PMC4684115.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4684115/
516. Hetland, Geir, Johnson, Egil, Lyberg, Torstein, Kvalheim, Gunnar, The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation, Advances in Pharmacological and Pharmaceutical Sciences, 2011, 157015, 10 pages, 2011. https://doi.org/10.1155/2011/157015
https://onlinelibrary.wiley.com/doi/10.1155/2011/157015
517. Pahwa R, Goyal A, Jialal I. Chronic Inflammation. [Updated 2023 Aug 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK493173/
518. Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2017 Dec 14;9(6):7204-7218. doi: 10.18632/oncotarget.23208. PMID: 29467962; PMCID: PMC5805548.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5805548/
519. Sarah Kraus, Nadir Arber, Inflammation and colorectal cancer, Current Opinion in Pharmacology, Volume 9, Issue 4, 2009, Pages 405-410, ISSN 1471-4892, https://doi.org/10.1016/j.coph.2009.06.006.
https://www.sciencedirect.com/science/article/abs/pii/S1471489209000812
520. Maddipati KR (2024) Distinct etiology of chronic inflammation – implications on degenerative diseases and cancer therapy. Front. Immunol. 15:1460302. doi: 10.3389/fimmu.2024.1460302
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1460302/full
521. Cacciatore, S.; Andaloro, S.; Bernardi, M.; Oterino Manzanas, A.; Spadafora, L.; Figliozzi, S.; Asher, E.; Rana, J.S.; Ecarnot, F.; Gragnano, F.; et al. Chronic Inflammatory Diseases and Cardiovascular Risk: Current Insights and Future Strategies for Optimal Management. Int. J. Mol. Sci. 2025, 26, 3071. https://doi.org/10.3390/ijms26073071
https://www.mdpi.com/1422-0067/26/7/3071
522. Placha D, Jampilek J. Chronic Inflammatory Diseases, Anti-Inflammatory Agents and Their Delivery Nanosystems. Pharmaceutics. 2021 Jan 6;13(1):64. doi: 10.3390/pharmaceutics13010064. PMID: 33419176; PMCID: PMC7825503.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7825503/
523. Alejandra P. Garza, Lorena Morton, Éva Pállinger, Edit I. Buzás, Stefanie Schreiber, Björn H. Schott, Ildiko Rita Dunay, Initial and ongoing tobacco smoking elicits vascular damage and distinct inflammatory response linked to neurodegeneration, Brain, Behavior, & Immunity - Health, Volume 28, 2023, 100597, ISSN 2666-3546, https://doi.org/10.1016/j.bbih.2023.100597.
https://www.sciencedirect.com/science/article/pii/S266635462300011X
524. Lee J, Taneja V, Vassallo R. Cigarette smoking and inflammation: cellular and molecular mechanisms. J Dent Res. 2012 Feb;91(2):142-9. doi: 10.1177/0022034511421200. Epub 2011 Aug 29. PMID: 21876032; PMCID: PMC3261116.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3261116/
525. Yan S, Ma Z, Jiao M, Wang Y, Li A and Ding S (2021) Effects of Smoking on Inflammatory Markers in a Healthy Population as Analyzed via the Gut Microbiota. Front. Cell. Infect. Microbiol. 11:633242. doi: 10.3389/fcimb.2021.633242
https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2021.633242/full
526. Smoking Can Be Hazardous to Your Joints, Linda Rath | April 20, 2023, Arthritis Foundation
https://www.arthritis.org/diseases/more-about/smoking-can-be-hazardous-to-joints
527. Stumpf F, Keller B, Gressies C, Schuetz P. Inflammation and Nutrition: Friend or Foe? Nutrients. 2023 Feb 25;15(5):1159. doi: 10.3390/nu15051159. PMID: 36904164; PMCID: PMC10005147.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10005147/
528. Scheiber A, Mank V. Anti-Inflammatory Diets. [Updated 2023 Oct 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK597377/
529. Elsayed EA, El Enshasy H, Wadaan MA, Aziz R. Mushrooms: a potential natural source of anti-inflammatory compounds for medical applications. Mediators Inflamm. 2014;2014:805841. doi: 10.1155/2014/805841. Epub 2014 Nov 23. PMID: 25505823; PMCID: PMC4258329.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4258329/
530. Du, Bin & Zhu, Fengmei & Xu, Baojun. (2018). An insight into the anti-inflammatory properties of edible and medicinal mushrooms. Journal of Functional Foods. 47. 10.1016/j.jff.2018.06.003.
https://www.researchgate.net/publication/325732957_An_insight_into_the_anti-inflammatory_properties_of_edible_and_medicinal_mushrooms
531. Venturella G, Ferraro V, Cirlincione F, Gargano ML. Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials. Int J Mol Sci. 2021 Jan 10;22(2):634. doi: 10.3390/ijms22020634. PMID: 33435246; PMCID: PMC7826851.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7826851/
532. Xia Y, Wang D, Li J, Chen M, Wang D, Jiang Z, Liu B. Compounds purified from edible fungi fight against chronic inflammation through oxidative stress regulation. Front Pharmacol. 2022 Sep 9;13:974794. doi: 10.3389/fphar.2022.974794. Erratum in: Front Pharmacol. 2023 Jan 05;13:1081523. doi: 10.3389/fphar.2022.1081523. PMID: 36160418; PMCID: PMC9500316.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9500316/
533. Hetland G, Johnson E, Bernardshaw SV, Grinde B. Can medicinal mushrooms have prophylactic or therapeutic effect against COVID-19 and its pneumonic superinfection and complicating inflammation? Scand J Immunol. 2021 Jan;93(1):e12937. doi: 10.1111/sji.12937. Epub 2020 Jul 29. PMID: 32657436; PMCID: PMC7404338.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7404338/
534. Phillips, J.M.; Ooi, S.L.; Pak, S.C. Health-Promoting Properties of Medicinal Mushrooms and Their Bioactive Compounds for the COVID-19 Era—An Appraisal: Do the Pro-Health Claims Measure Up? Molecules 2022, 27, 2302. https://doi.org/10.3390/molecules27072302
https://www.mdpi.com/1420-3049/27/7/2302
535. Lull C, Wichers HJ, Savelkoul HF. Antiinflammatory and immunomodulating properties of fungal metabolites. Mediators Inflamm. 2005 Jun 9;2005(2):63-80. doi: 10.1155/MI.2005.63. PMID: 16030389; PMCID: PMC1160565.
https://pmc.ncbi.nlm.nih.gov/articles/PMC1160565/
536. Emma Camilleri, Renald Blundell, Bikash Baral, Tomasz M. Karpinski, Edlira Aruci, Omar M. Atrooz, A brief overview of the medicinal and nutraceutical importance of Inonotus obliquus (chaga) mushrooms, Heliyon, Volume 10, Issue 15, 2024, e35638, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2024.e35638.
https://www.sciencedirect.com/science/article/pii/S2405844024116696
537. Yin Z, Zhang J, Qin J, Guo L, Guo Q, Kang W, Ma C and Chen L (2024) Anti-inflammatory properties of polysaccharides from edible fungi on health-promotion: a review. Front. Pharmacol. 15:1447677. doi: 10.3389/fphar.2024.1447677
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1447677/full
538. Adekunle Rowaiye, Olobayotan Ifeyomi Wilfred, Olukemi Adejoke Onuh, Doofan Bur, Solomon Oni, Ezinne Janefrances Nwonu, Gordon Ibeanu, Angus Nnamdi Oli, Timipanipiri ThankGod Wood, Modulatory Effects of Mushrooms on the Inflammatory Signaling Pathways and Pro-inflammatory Mediators, Clinical Complementary Medicine and Pharmacology, Volume 2, Issue 4, 2022, 100037, ISSN 2772-3712, https://doi.org/10.1016/j.ccmp.2022.100037.
https://www.sciencedirect.com/science/article/pii/S2772371222000183
539. Leslie SW, Soon-Sutton TL, Khan MAB. Male Infertility. [Updated 2024 Feb 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK562258/
540. Huang, B., Wang, Z., Kong, Y. et al. Global, regional and national burden of male infertility in 204 countries and territories between 1990 and 2019: an analysis of global burden of disease study. BMC Public Health 23, 2195 (2023). https://doi.org/10.1186/s12889-023-16793-3
https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-023-16793-3
541. Shah, Kirati M.; Gamit, Kanan G.; Raval, Manan A.; Vyas, Niraj Y.. Male infertility: A scoping review of prevalence, causes and treatments. Asian Pacific Journal of Reproduction 10(5):p 195-202, October 2021. | DOI: 10.4103/2305-0500.326717
https://journals.lww.com/apjr/fulltext/2021/10050/male_infertility__a_scoping_review_of_prevalence,.1.aspx
542. Agarwal A, Mulgund A, Hamada A, Chyatte MR. A unique view on male infertility around the globe. Reprod Biol Endocrinol. 2015 Apr 26;13:37. doi: 10.1186/s12958-015-0032-1. PMID: 25928197; PMCID: PMC4424520.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4424520/
543. Leslie SW, Soon-Sutton TL, Khan MAB. Male Infertility. 2024 Feb 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 32965929.
https://pubmed.ncbi.nlm.nih.gov/32965929/
544. How common is male infertility, and what are its causes? 11/18/2021, NIH Eunice Kennedy Shriver National Institute of Child Health and Human Development
https://www.nichd.nih.gov/health/topics/menshealth/conditioninfo/infertility
545. Dai JB, Wang ZX, Qiao ZD. The hazardous effects of tobacco smoking on male fertility. Asian J Androl. 2015 Nov-Dec;17(6):954-60. doi: 10.4103/1008-682X.150847. PMID: 25851659; PMCID: PMC4814952.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4814952/
546. Harlev A, Agarwal A, Gunes SO, Shetty A, du Plessis SS. Smoking and Male Infertility: An Evidence-Based Review. World J Mens Health. 2015 Dec;33(3):143-60. doi: 10.5534/wjmh.2015.33.3.143. Epub 2015 Dec 23. PMID: 26770934; PMCID: PMC4709430.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4709430/
547. Liu, Y., Chen, S., Pang, D. et al. Effects of paternal exposure to cigarette smoke on sperm DNA methylation and long-term metabolic syndrome in offspring. Epigenetics & Chromatin 15, 3 (2022). https://doi.org/10.1186/s13072-022-00437-8
https://epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-022-00437-8
548. Kovac JR, Labbate C, Ramasamy R, Tang D, Lipshultz LI. Effects of cigarette smoking on erectile dysfunction. Andrologia. 2015 Dec;47(10):1087-92. doi: 10.1111/and.12393. Epub 2014 Dec 29. PMID: 25557907; PMCID: PMC4485976.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4485976/
549. Skoracka K, Eder P, Łykowska-Szuber L, Dobrowolska A, Krela-Kaźmierczak I. Diet and Nutritional Factors in Male (In)fertility-Underestimated Factors. J Clin Med. 2020 May 9;9(5):1400. doi: 10.3390/jcm9051400. PMID: 32397485; PMCID: PMC7291266.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7291266/
550. Ferramosca A, Zara V. Diet and Male Fertility: The Impact of Nutrients and Antioxidants on Sperm Energetic Metabolism. Int J Mol Sci. 2022 Feb 25;23(5):2542. doi: 10.3390/ijms23052542. PMID: 35269682; PMCID: PMC8910394.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8910394/
551. Pecora, G., Sciarra, F., Gangitano, E. et al. How Food Choices Impact on Male Fertility. Curr Nutr Rep 12, 864–876 (2023). https://doi.org/10.1007/s13668-023-00503-x
https://link.springer.com/article/10.1007/s13668-023-00503-x#citeas
552. Almujaydil, M.S. The Role of Dietary Nutrients in Male Infertility: A Review. Life 2023, 13, 519. https://doi.org/10.3390/life13020519https://www.mdpi.com/2075-1729/13/2/519
553. Finelli R, Mottola F, Agarwal A. Impact of Alcohol Consumption on Male Fertility Potential: A Narrative Review. Int J Environ Res Public Health. 2021 Dec 29;19(1):328. doi: 10.3390/ijerph19010328. PMID: 35010587; PMCID: PMC8751073.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8751073/
554. Vaidya SR, Aeddula NR. Chronic Kidney Disease. [Updated 2024 Jul 31]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-
https://www.ncbi.nlm.nih.gov/books/NBK535404/
555. Kovesdy CP. Epidemiology of chronic kidney disease: an update 2022. Kidney Int Suppl (2011). 2022 Apr;12(1):7-11. doi: 10.1016/j.kisu.2021.11.003. Epub 2022 Mar 18. PMID: 35529086; PMCID: PMC9073222.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9073222/
556. Lv JC, Zhang LX. Prevalence and Disease Burden of Chronic Kidney Disease. Adv Exp Med Biol. 2019;1165:3-15. doi: 10.1007/978-981-13-8871-2_1. PMID: 31399958.
https://pubmed.ncbi.nlm.nih.gov/31399958/
557. Francis, A., Harhay, M.N., Ong, A.C.M. et al. Chronic kidney disease and the global public health agenda: an international consensus. Nat Rev Nephrol 20, 473–485 (2024). https://doi.org/10.1038/s41581-024-00820-6
https://www.nature.com/articles/s41581-024-00820-6
558. Yacoub R, Habib H, Lahdo A, Al Ali R, Varjabedian L, Atalla G, Kassis Akl N, Aldakheel S, Alahdab S, Albitar S. Association between smoking and chronic kidney disease: a case control study. BMC Public Health. 2010 Nov 25;10:731. doi: 10.1186/1471-2458-10-731. PMID: 21108832; PMCID: PMC3004836.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3004836/
559. Fu YC, Xu ZL, Zhao MY, Xu K. The Association Between Smoking and Renal Function in People Over 20 Years Old. Front Med (Lausanne). 2022 Jun 3;9:870278. doi: 10.3389/fmed.2022.870278. PMID: 35721101; PMCID: PMC9205397.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9205397/
560. Lang, S.M., Schiffl, H. Smoking status, cadmium, and chronic kidney disease. Ren Replace Ther 10, 17 (2024). https://doi.org/10.1186/s41100-024-00533-3
https://rrtjournal.biomedcentral.com/articles/10.1186/s41100-024-00533-3
561. Chen TK, Knicely DH, Grams ME. Chronic Kidney Disease Diagnosis and Management: A Review. JAMA. 2019 Oct 1;322(13):1294-1304. doi: 10.1001/jama.2019.14745. PMID: 31573641; PMCID: PMC7015670.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7015670/
562. Diagnosis - Chronic kidney disease, UK NHS
https://www.nhs.uk/conditions/kidney-disease/diagnosis/
563. Singh AK, Narsipur SS. Cyclosporine: A Commentary on Brand versus Generic Formulation Exchange. J Transplant. 2011;2011:480642. doi: 10.1155/2011/480642. Epub 2011 Nov 17. PMID: 22174986; PMCID: PMC3235899.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3235899/
564. Park H. The emergence of mycophenolate mofetilin dermatology: from its roots in the world of organ transplantation to its versatile role in the dermatology treatment room. J Clin Aesthet Dermatol. 2011 Jan;4(1):18-27. PMID: 21278895; PMCID: PMC3030212.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3030212/
565. Vivier, E., Rebuffet, L., Narni-Mancinelli, E. et al. Natural killer cell therapies. Nature 626, 727–736 (2024). https://doi.org/10.1038/s41586-023-06945-1
https://www.nature.com/articles/s41586-023-06945-1
566. Freud AG, Mundy-Bosse BL, Yu J, Caligiuri MA. The Broad Spectrum of Human Natural Killer Cell Diversity. Immunity. 2017 Nov 21;47(5):820-833. doi: 10.1016/j.immuni.2017.10.008. PMID: 29166586; PMCID: PMC5728700.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5728700/
567. Mace EM. Human natural killer cells: Form, function, and development. J Allergy Clin Immunol. 2023 Feb;151(2):371-385. doi: 10.1016/j.jaci.2022.09.022. Epub 2022 Oct 1. PMID: 36195172; PMCID: PMC9905317.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9905317/
568. Chen, S., Zhu, H. & Jounaidi, Y. Comprehensive snapshots of natural killer cells functions, signaling, molecular mechanisms and clinical utilization. Sig Transduct Target Ther 9, 302 (2024). https://doi.org/10.1038/s41392-024-02005-w
https://www.nature.com/articles/s41392-024-02005-w
569. Zaharescu, I.; Moldovan, A.D.; Tanase, C. Natural Killer (NK) Cells and Their Involvement in Different Types of Cancer—Current Status of Clinical Research. J. Mind Med. Sci. 2017, 4, 31-37. https://doi.org/10.22543/7674.41.P3137
https://www.mdpi.com/2392-7674/4/1/6
570. Lodoen MB, Lanier LL. Natural killer cells as an initial defense against pathogens. Curr Opin Immunol. 2006 Aug;18(4):391-8. doi: 10.1016/j.coi.2006.05.002. Epub 2006 Jun 12. PMID: 16765573; PMCID: PMC7127478.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7127478/
571. Inoue C, Takeshita T, Kondo H, Morimoto K. Cigarette smoking is associated with the reduction of lymphokine-activated killer cell and natural killer cell activities. Environ Health Prev Med. 1996 Apr;1(1):14-9. doi: 10.1007/BF02931167. PMID: 21432415.
https://pubmed.ncbi.nlm.nih.gov/21432415/
572. M. Takeuchi, S. Nagai, A. Nakajima, M. Shinya, C. Tsukano, H. Asada, K. Yoshikawa, M. Yoshimura, T. Izumi; Inhibition of Lung Natural Killer Cell Activity by Smoking: The Role of Alveolar Macrophages. Respiration 1 June 2001; 68 (3): 262–267. https://doi.org/10.1159/000050508
https://karger.com/res/article-abstract/68/3/262/288207/Inhibition-of-Lung-Natural-Killer-Cell-Activity-by?redirectedFrom=fulltext
573. Kanehisa Morimoto, Tatsuya Takeshita, Masanobu Nanno, Shinkan Tokudome, Kunio Nakayama, Modulation of natural killer cell activity by supplementation of fermented milk containing Lactobacillus casei in habitual smokers, Preventive Medicine, Volume 40, Issue 5, 2005, Pages 589-594, ISSN 0091-7435, https://doi.org/10.1016/j.ypmed.2004.07.019.
https://www.sciencedirect.com/science/article/abs/pii/S0091743504004177
574. Ferson, M., Edwards, A., Lind, A., Milton, G.W. and Hersey, P. (1979), Low natural killer-cell activity and immunoglobulin levels associated with smoking in human subjects. Int. J. Cancer, 23: 603-609. https://doi.org/10.1002/ijc.2910230504
https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.2910230504
575. Inoue, C., Takeshita, T., Kondo, H. et al. Cigarette smoking is associated with the reduction of lymphokine-activated killer cell and natural killer cell activities. Environ Health Prev Med 1, 14–19 (1996). https://doi.org/10.1007/BF02931167
https://link.springer.com/article/10.1007/BF02931167
576. Barone J, Hebert JR, Reddy MM. Dietary fat and natural-killer-cell activity. Am J Clin Nutr. 1989 Oct;50(4):861-7. doi: 10.1093/ajcn/50.4.861. PMID: 2801592.
https://pubmed.ncbi.nlm.nih.gov/2801592/
577. Giovanni Ravaglia, Paola Forti, Fabiola Maioli, Luciana Bastagli, Andrea Facchini, Erminia Mariani, Lucia Savarino, Simonetta Sassi, Domenico Cucinotta, Giorgio Lenaz, Effect of micronutrient status on natural killer cell immune function in healthy free-living subjects aged ≥90 y123, The American Journal of Clinical Nutrition, Volume 71, Issue 2, 2000, Pages 590-598, ISSN 0002-9165, https://doi.org/10.1093/ajcn/71.2.590.
https://www.sciencedirect.com/science/article/pii/S0002916523070260
578. Kim YS, Sayers TJ, Colburn NH, Milner JA, Young HA. Impact of dietary components on NK and Treg cell function for cancer prevention. Mol Carcinog. 2015 Sep;54(9):669-78. doi: 10.1002/mc.22301. Epub 2015 Apr 1. PMID: 25845339; PMCID: PMC4536099.
https://pubmed.ncbi.nlm.nih.gov/25845339/
579. Manash Pratim Pathak, Kalyani Pathak, Riya Saikia, Urvashee Gogoi, Mohammad Zaki Ahmad, Pompy Patowary, Aparoop Das, Immunomodulatory effect of mushrooms and their bioactive compounds in cancer: A comprehensive review, Biomedicine & Pharmacotherapy, Volume 149, 2022, 112901, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2022.112901.
https://www.sciencedirect.com/science/article/pii/S0753332222002906
580. Chang C-J, Chen Y-YM, Lu C-C, et al. Ganoderma lucidum stimulates NK cell cytotoxicity by inducing NKG2D/NCR activation and secretion of perforin and granulysin. Innate Immunity. 2013;20(3):301-311. doi:10.1177/1753425913491789
https://journals.sagepub.com/doi/full/10.1177/1753425913491789
581. Guggenheim AG, Wright KM, Zwickey HL. Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology. Integr Med (Encinitas). 2014 Feb;13(1):32-44. PMID: 26770080; PMCID: PMC4684115.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4684115/
582. Golden MI, Meyer JJ, Zeppieri M, Patel BC. Dry Eye Syndrome. 2024 Feb 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 29262012.
https://pubmed.ncbi.nlm.nih.gov/29262012/
583. Golden MI, Meyer JJ, Zeppieri M, et al. Dry Eye Syndrome. [Updated 2024 Feb 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470411/
https://www.ncbi.nlm.nih.gov/books/NBK470411/
584. Yamada M, Mizuno Y, Shigeyasu C. Impact of dry eye on work productivity. Clinicoecon Outcomes Res. 2012;4:307-12. doi: 10.2147/CEOR.S36352. Epub 2012 Oct 10. PMID: 23091391; PMCID: PMC3471464.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3471464/
585. Guo OD LW, Akpek E. The negative effects of dry eye disease on quality of life and visual function. Turk J Med Sci. 2020 Nov 3;50(SI-2):1611-1615. doi: 10.3906/sag-2002-143. PMID: 32283910; PMCID: PMC7672346.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7672346/
586. Wróbel-Dudzińska D, Osial N, Stępień PW, Gorecka A, Żarnowski T. Prevalence of Dry Eye Symptoms and Associated Risk Factors among University Students in Poland. Int J Environ Res Public Health. 2023 Jan 11;20(2):1313. doi: 10.3390/ijerph20021313. PMID: 36674068; PMCID: PMC9859544.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9859544/
587. He Q, Chen Z, Xie C, Liu L and Wei R (2022) The Association Between Dry Eye Disease With Depression, Anxiety and Sleep Disturbance During COVID-19. Front. Psychiatry 12:802302. doi: 10.3389/fpsyt.2021.802302
https://www.frontiersin.org/journals/psychiatry/articles/10.3389/fpsyt.2021.802302/full
588. Yang, K., Zhang, H., Wang, Y. et al. Evaluating the impact of smoking on the risk of dry eye disease: a two-sample Mendelian randomization study. Sci Rep 14, 32043 (2024). https://doi.org/10.1038/s41598-024-83795-5
https://www.nature.com/articles/s41598-024-83795-5
589. Solberg Y, Rosner M, Belkin M. The association between cigarette smoking and ocular diseases. Surv Ophthalmol. 1998 May-Jun;42(6):535-47. doi: 10.1016/s0039-6257(98)00002-2. PMID: 9635902.
https://pubmed.ncbi.nlm.nih.gov/9635902/
590. Xu L, Zhang W, Zhu XY, Suo T, Fan XQ, Fu Y. Smoking and the risk of dry eye: a Meta-analysis. Int J Ophthalmol. 2016 Oct 18;9(10):1480-1486. doi: 10.18240/ijo.2016.10.19. PMID: 27803868; PMCID: PMC5075666.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5075666/
591. Areesanan A, Wasilewicz A, Nicolay S, Grienke U, Zimmermann-Klemd AM, Rollinger JM and Gründemann C (2025) Evaluation of in vitro pharmacological activities of medicinal mushrooms in the context of dry eye disease. Front. Pharmacol. 16:1557359. doi: 10.3389/fphar.2025.1557359
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1557359/full
592. El Barche, FZ., Benyoussef, AA., El Habib Daho, M. et al. Automated tear film break-up time measurement for dry eye diagnosis using deep learning. Sci Rep 14, 11723 (2024). https://doi.org/10.1038/s41598-024-62636-5
https://www.nature.com/articles/s41598-024-62636-5
593. Cabaniss CD. Creatine Kinase. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Boston: Butterworths; 1990. Chapter 32.
https://www.ncbi.nlm.nih.gov/books/NBK352/https://www.ncbi.nlm.nih.gov/books/NBK352/
594. Brian R. Berridge, John F. Van Vleet, Eugene Herman, Chapter 46 - Cardiac, Vascular, and Skeletal Muscle Systems, Editor(s): Wanda M. Haschek, Colin G. Rousseaux, Matthew A. Wallig, Haschek and Rousseaux's Handbook of Toxicologic Pathology (Third Edition), Academic Press, 2013, Pages 1567-1665, ISBN 9780124157590, https://doi.org/10.1016/B978-0-12-415759-0.00046-7.
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/creatine-kinase
595. Moghadam-Kia S, Oddis CV, Aggarwal R. Approach to asymptomatic creatine kinase elevation. Cleve Clin J Med. 2016 Jan;83(1):37-42. doi: 10.3949/ccjm.83a.14120. PMID: 26760521; PMCID: PMC4871266.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4871266/
596. David S. Younger, Chapter 19 - Childhood muscular dystrophies, Editor(s): David S. Younger, Handbook of Clinical Neurology, Elsevier, Volume 195, 2023, Pages 461-496, ISSN 0072-9752, ISBN 9780323988186, https://doi.org/10.1016/B978-0-323-98818-6.00024-8.
https://www.sciencedirect.com/topics/nursing-and-health-professions/creatine-kinase-blood-level
597. Laurence A. Bindoff, CHAPTER 33 - Muscle disease, Editor(s): William J. Marshall, Marta Lapsley, Andrew P. Day, Ruth M. Ayling, Clinical Biochemistry: Metabolic and Clinical Aspects (Third Edition), Churchill Livingstone, 2014, Pages 646-659, ISBN 9780702051401, https://doi.org/10.1016/B978-0-7020-5140-1.00033-X.
https://www.sciencedirect.com/topics/nursing-and-health-professions/creatine-kinase-mm
598. Al-Naseem A, Sallam A, Choudhury S, Thachil J. Iron deficiency without anaemia: a diagnosis that matters. Clin Med (Lond). 2021 Mar;21(2):107-113. doi: 10.7861/clinmed.2020-0582. PMID: 33762368; PMCID: PMC8002799.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8002799/
599. Dufaux B, Hoederath A, Streitberger I, Hollmann W, Assmann G. Serum ferritin, transferrin, haptoglobin, and iron in middle- and long-distance runners, elite rowers, and professional racing cyclists. Int J Sports Med. 1981 Feb;2(1):43-6. doi: 10.1055/s-2008-1034583. PMID: 7333734.
https://pubmed.ncbi.nlm.nih.gov/7333734/
600. Nachtigall D, Nielsen P, Fischer R, Engelhardt R, Gabbe EE. Iron deficiency in distance runners. A reinvestigation using Fe-labelling and non-invasive liver iron quantification. Int J Sports Med. 1996 Oct;17(7):473-9. doi: 10.1055/s-2007-972881. PMID: 8912060.
https://pubmed.ncbi.nlm.nih.gov/8912060/
601. Dickson DN, Wilkinson RL, Noakes TD. Effects of ultra-marathon training and racing on hematologic parameters and serum ferritin levels in well-trained athletes. Int J Sports Med. 1982 May;3(2):111-7. doi: 10.1055/s-2008-1026073. PMID: 7107103.
https://pubmed.ncbi.nlm.nih.gov/7107103/
602. Stanzione JR, Bell G, Greenwood DA. A systematic nutrition intervention for low iron status in collegiate distance runners. Nutr Health. 2022 May 9:2601060221100337. doi: 10.1177/02601060221100337. Epub ahead of print. PMID: 35532088.
https://pubmed.ncbi.nlm.nih.gov/35532088/
603. Lai T-F, Liao Y, Hsueh M-C, Yen H-Y, Park J-H and Chang JH (2022) Substituting sedentary time with physical activity in youngest-old to oldest-old community-dwelling older adults: Associations with body composition. Front. Public Health 10:837213. doi: 10.3389/fpubh.2022.837213
https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.837213/full
604. Huang Z, Liu Y, Zhou Y. Sedentary Behaviors and Health Outcomes among Young Adults: A Systematic Review of Longitudinal Studies. Healthcare (Basel). 2022 Aug 6;10(8):1480. doi: 10.3390/healthcare10081480. PMID: 36011137; PMCID: PMC9408295.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9408295/
605. Bouamra M, Zouhal H, Ratel S, Makhlouf I, Bezrati I, Chtara M, Behm DG, Granacher U and Chaouachi A (2022) Concurrent Training Promotes Greater Gains on Body Composition and Components of Physical Fitness Than Single-Mode Training (Endurance or Resistance) in Youth With Obesity. Front. Physiol. 13:869063. doi: 10.3389/fphys.2022.869063
https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.869063/full
606. W.Clark Hersey, James E. Graves, Michael L. Pollock, Ronald Gingerich, Rachel B. Shireman, Gregory W. Heath, Francis Spierto, Steve D. McCole, James M. Hagberg, Endurance exercise training improves body composition and plasma insulin responses in 70- to 79-year-old men and women, Metabolism, Volume 43, Issue 7, 1994, Pages 847-854, ISSN 0026-0495, https://doi.org/10.1016/0026-0495(94)90265-8.
https://www.sciencedirect.com/science/article/abs/pii/0026049594902658
607. Júdice PB, Hetherington-Rauth M, Magalhães JP, Correia IR, Sardinha LB. Sedentary behaviours and their relationship with body composition of athletes. Eur J Sport Sci. 2022 Mar;22(3):474-480. doi: 10.1080/17461391.2021.1874060. Epub 2021 Feb 2. PMID: 33416024.
https://pubmed.ncbi.nlm.nih.gov/33416024/
608. SEPTEMBER 28, 2022 High-intensity workouts can help you get fit fast, but preparation is key By Cultivating Health, UC Davis Health
https://health.ucdavis.edu/blog/cultivating-health/high-intensity-workouts-can-help-you-get-fit-fast-but-preparation-is-key/2022/09
609. Verbrugghe J, Agten A, Stevens S, Hansen D, Demoulin C, Eijnde BO, Vandenabeele F, Timmermans A. High Intensity Training to Treat Chronic Nonspecific Low Back Pain: Effectiveness of Various Exercise Modes. J Clin Med. 2020 Jul 27;9(8):2401. doi: 10.3390/jcm9082401. PMID: 32727108; PMCID: PMC7465397.
https://pubmed.ncbi.nlm.nih.gov/32727108/
610. Wolski LA, McKenzie DC, Wenger HA. Altitude training for improvements in sea level performance. Is the scientific evidence of benefit? Sports Med. 1996 Oct;22(4):251-63. doi: 10.2165/00007256-199622040-00004. PMID: 8898458.
https://pubmed.ncbi.nlm.nih.gov/8898458/
611. Saunders PU, Pyne DB, Gore CJ. Endurance training at altitude. High Alt Med Biol. 2009 Summer;10(2):135-48. doi: 10.1089/ham.2008.1092. PMID: 19519223.
https://pubmed.ncbi.nlm.nih.gov/19519223/
612. Wolski LA, McKenzie DC, Wenger HA. Altitude training for improvements in sea level performance. Is the scientific evidence of benefit? Sports Med. 1996 Oct;22(4):251-63. doi: 10.2165/00007256-199622040-00004. PMID: 8898458.
https://pubmed.ncbi.nlm.nih.gov/8898458_2
613. Khodaee M, Grothe HL, Seyfert JH, VanBaak K. Athletes at High Altitude. Sports Health. 2016 Mar-Apr;8(2):126-32. doi: 10.1177/1941738116630948. PMID: 26863894; PMCID: PMC4789936.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4789936/
614. González-Ravé JM, Castillo JA, González-Mohino F and Pyne DB (2023) Periodization of altitude training: A collective case study of high-level swimmers. Front. Physiol. 14:1140077. doi: 10.3389/fphys.2023.1140077
https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1140077/full
615. Baoxia Chen, Zhusheng Wu, Xia Huang, Zhichao Li, Qianjin Wu, Zichao Chen, Effect of altitude training on the aerobic capacity of athletes: A systematic review and meta-analysis, Heliyon, Volume 9, Issue 9, 2023, e20188, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2023.e20188.
https://www.sciencedirect.com/science/article/pii/S2405844023073966
616. Deng, L.; Liu, Y.; Chen, B.; Hou, J.; Liu, A.; Yuan, X. Impact of Altitude Training on Athletes’ Aerobic Capacity: A Systematic Review and Meta-Analysis. Life 2025, 15, 305. https://doi.org/10.3390/life15020305
https://www.mdpi.com/2075-1729/15/2/305
617. Płoszczyca K, Langfort J, Czuba M. The Effects of Altitude Training on Erythropoietic Response and Hematological Variables in Adult Athletes: A Narrative Review. Front Physiol. 2018 Apr 11;9:375. doi: 10.3389/fphys.2018.00375. PMID: 29695978; PMCID: PMC5904371.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5904371/
618. High-Altitude Erythrocytosis: Mechanisms of Adaptive and Maladaptive Responses Francisco C. Villafuerte, Tatum S. Simonson, Daniela Bermudez, and Fabiola León-Velarde Physiology 2022 37:4, 175-186
https://journals.physiology.org/doi/full/10.1152/physiol.00029.2021
619. Man MC, Ganera C, Bărbuleț GD, Krzysztofik M, Panaet AE, Cucui AI, Tohănean DI, Alexe DI. The Modifications of Haemoglobin, Erythropoietin Values and Running Performance While Training at Mountain vs. Hilltop vs. Seaside. Int J Environ Res Public Health. 2021 Sep 8;18(18):9486. doi: 10.3390/ijerph18189486. PMID: 34574408; PMCID: PMC8466982.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8466982/
620. Biggs NC, England BS, Turcotte NJ, Cook MR, Williams AL. Effects of Simulated Altitude on Maximal Oxygen Uptake and Inspiratory Fitness. Int J Exerc Sci. 2017 Jan 1;10(1):127-136. doi: 10.70252/BARK5186. PMID: 28479953; PMCID: PMC5214464.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5214464/
621. Chen B, Wu Z, Huang X, Li Z, Wu Q, Chen Z. Effect of altitude training on the aerobic capacity of athletes: A systematic review and meta-analysis. Heliyon. 2023 Sep 16;9(9):e20188. doi: 10.1016/j.heliyon.2023.e20188. PMID: 37809554; PMCID: PMC10559955.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10559955/
622. Wu T, Ding S, Liu J, et al Smoking, acute mountain sickness and altitude acclimatisation: a cohort study Thorax 2012;67:914-919.
https://thorax.bmj.com/content/67/10/914.abstract
623. Stellingwerff T, Peeling P, Garvican-Lewis LA, Hall R, Koivisto AE, Heikura IA, Burke LM. Nutrition and Altitude: Strategies to Enhance Adaptation, Improve Performance and Maintain Health: A Narrative Review. Sports Med. 2019 Dec;49(Suppl 2):169-184. doi: 10.1007/s40279-019-01159-w. PMID: 31691928; PMCID: PMC6901429.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6901429/
624. Koivisto-Mørk AE, Paur I, Paulsen G, Garthe I, Raastad T, Bastani NE, Blomhoff R and Bøhn SK (2020) Dietary Adjustments to Altitude Training in Elite Endurance Athletes; Impact of a Randomized Clinical Trial With Antioxidant-Rich Foods. Front. Sports Act. Living 2:106. doi: 10.3389/fspor.2020.00106
https://www.frontiersin.org/journals/sports-and-active-living/articles/10.3389/fspor.2020.00106/full
625. Tapia C, Nessel TA, Zito PM. Cyclosporine. [Updated 2023 Aug 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK482450/
626. Takeda A, Uchida K, Haba T, Tominaga Y, Katayama A, Yoshida A, Oikawa T, Morozumi K. Chronic cyclosporin nephropathy: long-term effects of cyclosporin on renal allografts. Clin Transplant. 2001;15 Suppl 5:22-9. doi: 10.1034/j.1399-0012.2001.0150s5022.x. PMID: 11791791.
https://pubmed.ncbi.nlm.nih.gov/11791791/
627. Jun Yu, Xiao Wei, Jinzhang Gao, Chun Wang, Wei Wei, Role of cyclosporin A in the treatment of kidney disease and nephrotoxicity, Toxicology, Volume 492, 2023, 153544, ISSN 0300-483X, https://doi.org/10.1016/j.tox.2023.153544.
https://www.sciencedirect.com/science/article/abs/pii/S0300483X23001300
628. Einollahi B, Teimoori M, A Systematic Review about an Advance in Cyclosporine Monitoring in Kidney Transplant Recipients.Nephro-Urol Mon.2017;9(4):e24989.https://doi.org/10.5812/numonthly.24989.
https://brieflands.com/articles/num-55530
629. Ng TH, Britton GJ, Hill EV, Verhagen J, Burton BR, Wraith DC. Regulation of adaptive immunity; the role of interleukin-10. Front Immunol. 2013 May 31;4:129. doi: 10.3389/fimmu.2013.00129. PMID: 23755052; PMCID: PMC3668291.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3668291/
630. Iyer SS, Cheng G. Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease. Crit Rev Immunol. 2012;32(1):23-63. doi: 10.1615/critrevimmunol.v32.i1.30. PMID: 22428854; PMCID: PMC3410706.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3410706/
631. Kaliyaperumal, Y., Sivadasan, S. & Aiyalu, R. Contrast-Induced Nephropathy: An Overview. Dr. Sulaiman Al Habib Med J 5, 118–127 (2023). https://doi.org/10.1007/s44229-023-00040-3
https://link.springer.com/article/10.1007/s44229-023-00040-3
632. Mohammed NM, Mahfouz A, Achkar K, Rafie IM, Hajar R. Contrast-induced Nephropathy. Heart Views. 2013 Jul;14(3):106-16. doi: 10.4103/1995-705X.125926. PMID: 24696755; PMCID: PMC3969626.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3969626/
633. Modi K, Padala SA, Gupta M. Contrast-Induced Nephropathy. [Updated 2025 Jan 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan
https://www.ncbi.nlm.nih.gov/books/NBK448066/
634. R. Mehran, E. Nikolsky, Contrast-induced nephropathy: Definition, epidemiology, and patients at risk, Kidney International, Volume 69, Supplement 100, 2006, Pages S11-S15, ISSN 0085-2538, https://doi.org/10.1038/sj.ki.5000368.
https://www.sciencedirect.com/science/article/pii/S0085253815513872
635. Tascón, J.; Prieto, M.; Casanova, A.G.; Sanz, F.J.; Hernández Mezquita, M.A.; Barrueco Ferrero, M.; Gomez-Marcos, M.A.; Garcia-Ortiz, L.; Vicente-Vicente, L.; Morales, A.I.; et al. Early Diagnosis of Kidney Damage Associated with Tobacco Use: Preventive Application. J. Pers. Med. 2022, 12, 1032. https://doi.org/10.3390/jpm12071032
https://www.mdpi.com/2075-4426/12/7/1032
636. Charlene (Xiaoying) Deng, MD, PhD, MBA, FACP, FASN Assistant Professor of Medicine, Division of Nephrology, Hypertension and Transplantation, Thomas Jefferson University Hospital, Sidney Kimmel Medical College of Thomas Jefferson University
https://emedicine.medscape.com/article/246751-treatment
637. Ying M, Yang J, Huang Z, Ling Y, Wang B, Huang H, Li Q, Liu J, Liu Y, Chen Z. Association between malnutrition and contrast-associated acute kidney injury in congestive heart failure patients following coronary angiography. Front Nutr. 2022 Nov 17;9:937237. doi: 10.3389/fnut.2022.937237. PMID: 36466405; PMCID: PMC9713008.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9713008/
638. Liang J, Zhang L, Huang Z, He Y, Ling Y, Chen K, Ying M, Lin M, Li G, Liu J, Liu Y, Liang Y, Chen S and Hu Y (2022) Implications of Malnutrition on Contrast-Associated Acute Kidney Injury in Young and Old Patients Undergoing Percutaneous Coronary Intervention: A Multicenter Prospective Cohort. Front. Nutr. 8:795068. doi: 10.3389/fnut.2021.795068
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.795068/full
639. Chen, Liling & Huang, Zhidong & Li, Weiguo & He, Yibo & Liang, Jingjing & Lu, Jin & Yang, Yanfang & Huang, Haozhang & Lin, Yihang & Lin, Rongwen & Lin, Mengfei & Liang, Yan & Hu, Yunzhao & Ye, Jianfeng & Hu, Yuying & Liu, Jin & Liu, Yong & Fang, Yong & Chen, Kaihong & Chen, Shiqun. (2022). Malnutrition and the risk for contrast-induced acute kidney injury in patients with coronary artery disease. International Urology and Nephrology. 54. 10.1007/s11255-021-02915-6.
https://www.researchgate.net/publication/352758623_Malnutrition_and_the_risk_for_contrast-induced_acute_kidney_injury_in_patients_with_coronary_artery_disease
640. Liang J, Zhang L, Huang Z, He Y, Ling Y, Chen K, Ying M, Lin M, Li G, Liu J, Liu Y, Liang Y, Chen S, Hu Y. Implications of Malnutrition on Contrast-Associated Acute Kidney Injury in Young and Old Patients Undergoing Percutaneous Coronary Intervention: A Multicenter Prospective Cohort. Front Nutr. 2022 Feb 8;8:795068. doi: 10.3389/fnut.2021.795068. PMID: 35211494; PMCID: PMC8861456.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8861456/
641. Ruth W. Mwangi, John M. Macharia, Isabel N. Wagara, Raposa L. Bence, The antioxidant potential of different edible and medicinal mushrooms, Biomedicine & Pharmacotherapy, Volume 147, 2022, 112621, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2022.112621.
https://www.sciencedirect.com/science/article/pii/S0753332222000099
642. Karunarathna, S. C., Prasannath, K., Lu, W., & Hapuarachchi, K. K. (2024). Ganoderma: bridging traditional wisdom with modern innovation in medicinal mushroom and dietary supplement industry. New Zealand Journal of Botany, 1–60. https://doi.org/10.1080/0028825X.2024.2410486
https://www.tandfonline.com/doi/abs/10.1080/0028825X.2024.2410486
643. Musa R, Rout P, Qurie A. Lupus Nephritis. [Updated 2025 Jan 16]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK499817/
644. Soo-Kyung Cho, Hyoungyoung Kim, Jung-Yong Han, Yena Jeon, Sun-Young Jung, Eun Jin Jang, Yoon-Kyoung Sung, Risk of end-stage renal disease in patients with early-onset lupus nephritis: A population-based cohort study, Seminars in Arthritis and Rheumatism, Volume 63, 2023, 152308, ISSN 0049-0172, https://doi.org/10.1016/j.semarthrit.2023.152308.
https://www.sciencedirect.com/science/article/abs/pii/S0049017223001506
645. Hoover PJ, Costenbader KH. Insights into the epidemiology and management of lupus nephritis from the US rheumatologist's perspective. Kidney Int. 2016 Sep;90(3):487-92. doi: 10.1016/j.kint.2016.03.042. Epub 2016 Jun 22. PMID: 27344205; PMCID: PMC5679458.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5679458/
646. A smoking gun for renal disease in patients with SLE?. Nat Rev Rheumatol 11, 562 (2015). https://doi.org/10.1038/nrrheum.2015.122
https://www.nature.com/articles/nrrheum.2015.122
647. Xu D, You X, Wang Z, Zeng Q, Xu J, Jiang L, Gong L, Wu F, Gu J, Tao Y, Chen J, Zhao J, Li M, Zhao Y, Zeng X; CSTAR co-authors. Chinese Systemic Lupus Erythematosus Treatment and Research Group Registry VI: Effect of Cigarette Smoking on the Clinical Phenotype of Chinese Patients with Systemic Lupus Erythematosus. PLoS One. 2015 Aug 17;10(8):e0134451. doi: 10.1371/journal.pone.0134451. PMID: 26280671; PMCID: PMC4539270.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4539270/
648. Islam MA, Khandker SS, Kotyla PJ, Hassan R. Immunomodulatory Effects of Diet and Nutrients in Systemic Lupus Erythematosus (SLE): A Systematic Review. Front Immunol. 2020 Jul 22;11:1477. doi: 10.3389/fimmu.2020.01477. PMID: 32793202; PMCID: PMC7387408.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7387408/
649. Krause KM, Serio AW, Kane TR, Connolly LE. Aminoglycosides: An Overview. Cold Spring Harb Perspect Med. 2016 Jun 1;6(6):a027029. doi: 10.1101/cshperspect.a027029. PMID: 27252397; PMCID: PMC4888811.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4888811/
650. Jose M. Lopez-Novoa, Yaremi Quiros, Laura Vicente, Ana I. Morales, Francisco J. Lopez-Hernandez, New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view, Kidney International, Volume 79, Issue 1, 2011, Pages 33-45, ISSN 0085-2538, https://doi.org/10.1038/ki.2010.337.
https://www.sciencedirect.com/science/article/pii/S0085253815546760
651. Swan SK. Aminoglycoside nephrotoxicity. Semin Nephrol. 1997 Jan;17(1):27-33. PMID: 9000547.
https://pubmed.ncbi.nlm.nih.gov/9000547/
652. Dobrek, L. A Synopsis of Current Theories on Drug-Induced Nephrotoxicity. Life 2023, 13, 325. https://doi.org/10.3390/life13020325
https://www.mdpi.com/2075-1729/13/2/325
653. Staging liver fibrosis and cirrhosis using non-invasive tests in people with chronic hepatitis B to inform WHO 2024 guidelines: a systematic review and meta-analysis Liguori, Antonio et al. The Lancet Gastroenterology & Hepatology, Volume 10, Issue 4, 332 - 349
https://www.thelancet.com/journals/langas/article/PIIS2468-1253(24)00437-0/fulltext
654. Ji Huang, Yongqi Liu, Youshun Liu, Antiviral therapy in hepatitis B virus-infected with immune-tolerant: A meta-analysis, Gastroenterología y Hepatología (English Edition), Volume 46, Issue 4, 2023, Pages 309-318, ISSN 2444-3824, https://doi.org/10.1016/j.gastre.2022.05.011.
https://www.sciencedirect.com/science/article/abs/pii/S2444382423000706
655. Parikh P, Ryan JD, Tsochatzis EA. Fibrosis assessment in patients with chronic hepatitis B virus (HBV) infection. Ann Transl Med. 2017 Feb;5(3):40. doi: 10.21037/atm.2017.01.28. PMID: 28251119; PMCID: PMC5326648.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5326648/
656. You, H., Wang, X., Ma, L. et al. Insights into the impact of hepatitis B virus on hepatic stellate cell activation. Cell Commun Signal 21, 70 (2023). https://doi.org/10.1186/s12964-023-01091-7
https://biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01091-7
657. Bedossa P. Reversibility of hepatitis B virus cirrhosis after therapy: who and why? Liver Int. 2015 Jan;35 Suppl 1:78-81. doi: 10.1111/liv.12710. PMID: 25529091.
https://pubmed.ncbi.nlm.nih.gov/25529091/
658. Yameng Sun, Xiaoning Wu, Jialing Zhou, Tongtong Meng, Bingqiong Wang, Shuyan Chen, Hui Liu, Tailing Wang, Xinyan Zhao, Shanshan Wu, Yuanyuan Kong, Xiaojuan Ou, Aileen Wee, Neil D. Theise, Chao Qiu, Wenhong Zhang, Fengmin Lu, Jidong Jia, Hong You, Persistent Low Level of Hepatitis B Virus Promotes Fibrosis Progression During Therapy, Clinical Gastroenterology and Hepatology, Volume 18, Issue 11, 2020, Pages 2582-2591.e6, ISSN 1542-3565, https://doi.org/10.1016/j.cgh.2020.03.001.
https://www.sciencedirect.com/science/article/pii/S154235652030272X
659. Soares AA, de Sá-Nakanishi AB, Bracht A, da Costa SM, Koehnlein EA, de Souza CG, Peralta RM. Hepatoprotective effects of mushrooms. Molecules. 2013 Jul 1;18(7):7609-30. doi: 10.3390/molecules18077609. PMID: 23884116; PMCID: PMC6270077.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6270077/
660. Bhatia, Aditya & Neeraj, Dr. (2024). Medicinal Mushrooms: A promising frontier in hepatitis treatment. 05. 19-24.
https://www.researchgate.net/publication/380721790_Medicinal_Mushrooms_A_promising_frontier_in_hepatitis_treatment
661. Abramyan S, Hanlon M. Kidney Transplantation. [Updated 2023 Jan 2]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK567755/
662. Patrick Yoon Kim, Azarin Shoghi, Ghaneh Fananapazir, Renal Transplantation: Immediate and Late Complications, Radiologic Clinics of North America, Volume 61, Issue 5, 2023, Pages 809-820, ISSN 0033-8389, ISBN 9780443181771, https://doi.org/10.1016/j.rcl.2023.04.004.
https://www.sciencedirect.com/science/article/abs/pii/S0033838923001161
663. Naik RH, Shawar SH. Renal Transplantation Rejection. [Updated 2023 Feb 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK553074/
664. The National Kidney Federation, What is transplant rejection? March 2023
https://www.kidney.org.uk/what-is-transplant-rejection
665. Weinrauch LA, Claggett B, Liu J, Finn PV, Weir MR, Weiner DE, D'Elia JA. Smoking and outcomes in kidney transplant recipients: a post hoc survival analysis of the FAVORIT trial. Int J Nephrol Renovasc Dis. 2018 Apr 27;11:155-164. doi: 10.2147/IJNRD.S161001. PMID: 29760559; PMCID: PMC5937486.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5937486/
666. Salamah, Sovia1; Gomes Neto, Antonio Wouter1; Alkaff, Firas F.1,2; Kootstra-Ros, Jenny E.1; Touw, Daniel J.1; Franssen, Casper F.M.1; Bakker, Stephan J.L.1. Carboxyhemoglobin and Smoking Status in Kidney Transplant Recipients: TH-PO791. Journal of the American Society of Nephrology 35(10S):10.1681/ASN.2024s9tskgx2, October 2024. | DOI: 10.1681/ASN.2024s9tskgx2
https://journals.lww.com/jasn/fulltext/2024/10001/carboxyhemoglobin_and_smoking_status_in_kidney.1114.aspx
667. Christie Rampersad, Jason Bau, Ani Orchanian-Cheff, S. Joseph Kim, Impact of donor smoking history on kidney transplant recipient outcomes: A systematic review and meta-analysis, Transplantation Reviews, Volume 38, Issue 3, 2024, 100854, ISSN 0955-470X, https://doi.org/10.1016/j.trre.2024.100854.
https://www.sciencedirect.com/science/article/pii/S0955470X24000375
668. Khalil MAM, Tan J, Khamis S, Khalil MA, Azmat R, Ullah AR. Cigarette Smoking and Its Hazards in Kidney Transplantation. Adv Med. 2017;2017:6213814. doi: 10.1155/2017/6213814. Epub 2017 Jul 27. PMID: 28819637; PMCID: PMC5551477.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5551477/
669. Sara T. Stoler, Maria Chan, Steven J. Chadban, Nutrition in the Management of Kidney Transplant Recipients, Journal of Renal Nutrition, Volume 33, Issue 6, Supplement, 2023, Pages S67-S72, ISSN 1051-2276, https://doi.org/10.1053/j.jrn.2023.07.001.
https://www.sciencedirect.com/science/article/abs/pii/S1051227623001085
670. Stoler ST, Chan M, Chadban SJ. Nutrition in the Management of Kidney Transplant Recipients. J Ren Nutr. 2023 Nov;33(6S):S67-S72. doi: 10.1053/j.jrn.2023.07.001. Epub 2023 Jul 22. PMID: 37482148.
https://pubmed.ncbi.nlm.nih.gov/37482148/
671. Azer SA, Hashmi MF, Reddivari AKR. Gastroesophageal Reflux Disease (GERD) [Updated 2024 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK554462/
672. Shaqran TM, Ismaeel MM, Alnuaman AA, Al Ahmad FA, Albalawi GA, Almubarak JN, AlHarbi RS, Alaqidi RS, AlAli YA, Alfawaz KS, Daghriri AA. Epidemiology, Causes, and Management of Gastro-esophageal Reflux Disease: A Systematic Review. Cureus. 2023 Oct 21;15(10):e47420. doi: 10.7759/cureus.47420. PMID: 38022211; PMCID: PMC10658748.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10658748/
673. Nirwan, J.S., Hasan, S.S., Babar, ZUD. et al. Global Prevalence and Risk Factors of Gastro-oesophageal Reflux Disease (GORD): Systematic Review with Meta-analysis. Sci Rep 10, 5814 (2020). https://doi.org/10.1038/s41598-020-62795-1
https://www.nature.com/articles/s41598-020-62795-1
674. Baklola, M., Terra, M., Badr, A. et al. Prevalence of gastro-oesophageal reflux disease, and its associated risk factors among medical students: a nation-based cross-sectional study. BMC Gastroenterol 23, 269 (2023). https://doi.org/10.1186/s12876-023-02899-w
https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-023-02899-w
675. Zhang D, Liu S, Li Z, Wang R. Global, regional and national burden of gastroesophageal reflux disease, 1990-2019: update from the GBD 2019 study. Ann Med. 2022 Dec;54(1):1372-1384. doi: 10.1080/07853890.2022.2074535. PMID: 35579516; PMCID: PMC9122392.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9122392/
676. Eivind Ness-Jensen, Jesper Lagergren, Tobacco smoking, alcohol consumption and gastro-oesophageal reflux disease, Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 5, 2017, Pages 501-508, ISSN 1521-6918, https://doi.org/10.1016/j.bpg.2017.09.004.
https://www.sciencedirect.com/science/article/abs/pii/S1521691817300999
677. Yen P-C, Geng J-H, Wu P-Y, Huang J-C, Hu H-M, Kuo C-H and Chen S-C (2024) Secondhand smoke is associated with peptic ulcer disease and gastroesophageal reflux disease in non-smokers in a large Taiwanese population study. Front. Public Health. 12:1450481. doi: 10.3389/fpubh.2024.1450481
https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1450481/full
678. Gomm W, von Holt K, Thomé F, et al. Association of Proton Pump Inhibitors With Risk of Dementia: A Pharmacoepidemiological Claims Data Analysis. JAMA Neurol. 2016;73(4):410–416. doi:10.1001/jamaneurol.2015.4791
https://jamanetwork.com/journals/jamaneurology/fullarticle/2487379
679. Ortiz-Guerrero G, Amador-Muñoz D, Calderón-Ospina CA, López-Fuentes D, Nava Mesa MO. Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences. Neural Plast. 2018 Mar 21;2018:5257285. doi: 10.1155/2018/5257285. PMID: 29755512; PMCID: PMC5883984.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5883984/
680. Northuis CA, Bell EJ, Lutsey PL, George KM, Gottesman RF, Mosley TH, Whitsel EA, Lakshminarayan K. Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study. Neurology. 2023 Oct 31;101(18):e1771-e1778. doi: 10.1212/WNL.0000000000207747. Epub 2023 Aug 9. Erratum in: Neurology. 2024 Jul 9;103(1):e209596. doi: 10.1212/WNL.0000000000209596. PMID: 37558503; PMCID: PMC10634644.
https://www.neurology.org/doi/10.1212/WNL.0000000000207747
681. Common questions about esomeprazole, 7 January 2022 NHS of UK
https://www.nhs.uk/medicines/esomeprazole/common-questions-about-esomeprazole/
682. Published July 19, 2017 GASTROENTEROLOGY Proton Pump Inhibitors: Considerations With Long-Term Use, Emily M. Ambizas, PharmD, MPH, BCGP, Joseph V. Etzel, PharmD
https://www.uspharmacist.com/article/proton-pump-inhibitors-considerations-with-longterm-use
683. Maideen NMP. Adverse Effects Associated with Long-Term Use of Proton Pump Inhibitors. Chonnam Med J. 2023 May;59(2):115-127. doi: 10.4068/cmj.2023.59.2.115. Epub 2023 May 25. PMID: 37303818; PMCID: PMC10248387.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10248387/
684. Munir U, Tafti D, Morgan S. Morton Neuroma. [Updated 2023 May 22]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan
https://www.ncbi.nlm.nih.gov/books/NBK470249/
685. Potu, Bhagath & Saleem, Bader & Almarabheh, Amer. (2023). Prevalence of Morton’s toe and assessment of the associated risk factors: a cross-sectional study. European Journal of Anatomy. 717-722. 10.52083/ZOJG4094.
https://www.researchgate.net/publication/375178146_Prevalence_of_Morton%27s_toe_and_assessment_of_the_associated_risk_factors_a_cross-sectional_study
686. del Mar Ruiz-Herrera, M.; Criado-Álvarez, J.J.; Suarez-Ortiz, M.; Konschake, M.; Moroni, S.; Marcos-Tejedor, F. Study of the Anatomical Association between Morton’s Neuroma and the Space Inferior to the Deep Transverse Metatarsal Ligament Using Ultrasound. Diagnostics 2022, 12, 1367. https://doi.org/10.3390/diagnostics12061367
https://www.mdpi.com/2075-4418/12/6/1367
687. Symeonidis PD, Iselin LD, Simmons N, Fowler S, Dracopoulos G, Stavrou P. Prevalence of interdigital nerve enlargements in an asymptomatic population. Foot Ankle Int. 2012 Jul;33(7):543-7. doi: 10.3113/FAI.2012.0543. PMID: 22835390.
https://pubmed.ncbi.nlm.nih.gov/22835390/
This suggests that a significant portion of the population may have radiologically visible Morton's neuromas, even if they aren't experiencing symptoms.
688. What is a Morton’s neuroma? June 6, 2024, uclahealth
https://www.uclahealth.org/news/article/what-mortons-neuroma
689. Matthews BG, Thomson CE, McKinley JC, Harding MP, Ware RS. Treatments for Morton's neuroma. Cochrane Database Syst Rev. 2021 Jul 14;2021(7):CD014687. doi: 10.1002/14651858.CD014687. PMCID: PMC8277559.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8277559/
690. Naik RH, Shawar SH. Renal Transplantation Rejection. 2023 Feb 9. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 31971715.
https://pubmed.ncbi.nlm.nih.gov/31971715/
691. Justiz Vaillant AA, Misra S, Fitzgerald BM. Acute Transplantation Rejection. [Updated 2024 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK535410/
692. Maria Sandovici, Leo E. Deelman, Dick de Zeeuw, Harry van Goor, Robert H. Henning, Immune modulation and graft protection by gene therapy in kidney transplantation, European Journal of Pharmacology, Volume 585, Issues 2–3, 2008, Pages 261-269, ISSN 0014-2999, https://doi.org/10.1016/j.ejphar.2008.02.087.
https://www.sciencedirect.com/science/article/abs/pii/S0014299908002811
693. Oweira H, Ramouz A, Ghamarnejad O, Khajeh E, Ali-Hasan-Al-Saegh S, Nikbakhsh R, Reißfelder C, Rahbari N, Mehrabi A, Sadeghi M. Risk Factors of Rejection in Renal Transplant Recipients: A Narrative Review. J Clin Med. 2022 Mar 3;11(5):1392. doi: 10.3390/jcm11051392. PMID: 35268482; PMCID: MC8911293.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8911293/
694. Alasfar, S.; Kodali, L.; Schinstock, C.A. Current Therapies in Kidney Transplant Rejection. J. Clin. Med. 2023, 12, 4927. https://doi.org/10.3390/jcm12154927
https://www.mdpi.com/2077-0383/12/15/4927
695. Aref A, Sharma A, Halawa A. Smoking in Renal Transplantation; Facts Beyond Myth. World J Transplant. 2017 Apr 24;7(2):129-133. doi: 10.5500/wjt.v7.i2.129. PMID: 28507915; PMCID: PMC5409912.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5409912/
696 Arnaud Devresse, Sophie Gohy, Arnaud Robert, Nada Kanaan, How to manage cigarette smoking in kidney transplant candidates and recipients?, Clinical Kidney Journal, Volume 14, Issue 11, November 2021, Pages 2295–2303, https://doi.org/10.1093/ckj/sfab072
https://academic.oup.com/ckj/article/14/11/2295/6204102
697. Simone A. Joosten, YVO W.J. Sijpkens, Cees van Kooten, Leendert C. Paul, Chronic renal allograft rejection: Pathophysiologic considerations, Kidney International, Volume 68, Issue 1, 2005, Pages 1-13, ISSN 0085-2538, https://doi.org/10.1111/j.1523-1755.2005.00376.x.
https://www.sciencedirect.com/science/article/pii/S0085253815508090
698. Sung RS, Althoen M, Howell TA, Ojo AO, Merion RM. Excess risk of renal allograft loss associated with cigarette smoking. Transplantation. 2001 Jun 27;71(12):1752-7. doi: 10.1097/00007890-200106270-00009. PMID: 11455254.
https://pubmed.ncbi.nlm.nih.gov/11455254/
699. Agarwal, P. K., Hellemons, M. E., Zelle, D. M., van Ree, R. M., van den Born, J., van der Heide, J. J. H., Gans, R. O. B., van Son, W. J., Navis, G., & Bakker, S. J. L. (2011). Smoking Is a Risk Factor for Graft Failure and Mortality after Renal Transplantation. American Journal of Nephrology, 34(1), 26-31. https://doi.org/10.1159/000328903
https://pure.eur.nl/en/publications/smoking-is-a-risk-factor-for-graft-failure-and-mortality-after-re
700. Nourbala, Mohammad & Nemati, Eghlim & Rostami, Zohreh & Einollahi, Behzad. (2011). Impact of Cigarette Smoking on Kidney Transplant Recipients A Systematic Review. Iranian journal of kidney diseases. 5. 141-8.
https://www.researchgate.net/publication/51082216_Impact_of_Cigarette_Smoking_on_Kidney_Transplant_Recipients_A_Systematic_Review
701. Agarwal PK, Hellemons ME, Zelle DM, van Ree RM, van den Born J, van der Heide JJ, Gans RO, van Son WJ, Navis G, Bakker SJ. Smoking is a risk factor for graft failure and mortality after renal transplantation. Am J Nephrol. 2011;34(1):26-31. doi: 10.1159/000328903. Epub 2011 Jun 9. PMID: 21659736.
https://pubmed.ncbi.nlm.nih.gov/21659736/
702. Shamsudheen, M. P.; Kuchay, Abid; Gupta, Vijay Chander; Tiwari, Isha; Karthik, Raja,*; Das, Uttara; Guditi, Swarnalatha; Taduri, Gangadhar. Allograft Rejection in Kidney Transplantation – A Retrospective Study of Impact on Graft and Patient Outcome. Indian Journal of Transplantation 16(4):p 371-376, Oct–Dec 2022. | DOI: 10.4103/ijot.ijot_93_21
https://journals.lww.com/ijjt/fulltext/2022/16040/allograft_rejection_in_kidney_transplantation___a.4.aspx
703. Cyrino LG, Galpern J, Moore L, Borgi L, Riella LV. A Narrative Review of Dietary Approaches for Kidney Transplant Patients. Kidney Int Rep. 2021 Apr 27;6(7):1764-1774. doi: 10.1016/j.ekir.2021.04.009. PMID: 34307973; PMCID: PMC8258457.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8258457/
704. Abdulla K. Salahudeen, Thomas H. Hostetter, Susan K. Raatz, Mark E. Rosenberg, Effects of dietary protein in patients with chronic renal transplant rejection, Kidney International, Volume 41, Issue 1, 1992, Pages 183-190, ISSN 0085-2538, https://doi.org/10.1038/ki.1992.25.
https://www.sciencedirect.com/science/article/pii/S0085253815574462
705. Sengupta P, Chaudhuri A, Rathore K, Biswas S. Nutritional management of kidney transplant recipient. Proceedings of Singapore Healthcare. 2025;34. doi:10.1177/20101058251327810
https://journals.sagepub.com/doi/10.1177/20101058251327810
706. Meade E, Hehir S, Rowan N, Garvey M. Mycotherapy: Potential of Fungal Bioactives for the Treatment of Mental Health Disorders and Morbidities of Chronic Pain. J Fungi (Basel). 2022 Mar 11;8(3):290. doi: 10.3390/jof8030290. PMID: 35330292; PMCID: PMC8954642.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8954642/
707. Amaya-Amaya J, Rojas-Villarraga A, Mantilla RD, et al. Rheumatoid arthritis. In: Anaya JM, Shoenfeld Y, Rojas-Villarraga A, et al., editors. Autoimmunity: From Bench to Bedside [Internet]. Bogota (Colombia): El Rosario University Press; 2013 Jul 18. Chapter 24. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459454/
708. Venetsanopoulou AI, Alamanos Y, Voulgari PV, Drosos AA. Epidemiology and Risk Factors for Rheumatoid Arthritis Development. Mediterr J Rheumatol. 2023 Dec 30;34(4):404-413. doi: 10.31138/mjr.301223.eaf. PMID: 38282942; PMCID: PMC10815538.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10815538/
709. Safiri S, Kolahi AA, Hoy D, Smith E, Bettampadi D, Mansournia MA, Almasi-Hashiani A, Ashrafi-Asgarabad A, Moradi-Lakeh M, Qorbani M, Collins G, Woolf AD, March L, Cross M. Global, regional and national burden of rheumatoid arthritis 1990-2017: a systematic analysis of the Global Burden of Disease study 2017. Ann Rheum Dis. 2019 Nov;78(11):1463-1471. doi: 10.1136/annrheumdis-2019-215920. Epub 2019 Sep 11. PMID: 31511227.
https://pubmed.ncbi.nlm.nih.gov/31511227/
710. Panagopoulos PK, Lambrou GI. Bone erosions in rheumatoid arthritis: recent developments in pathogenesis and therapeutic implications. J Musculoskelet Neuronal Interact. 2018 Sep 1;18(3):304-319. PMID: 30179207; PMCID: PMC6146189.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6146189/
711. InformedHealth.org [Internet]. Cologne, Germany: Institute for Quality and Efficiency in Health Care (IQWiG); 2006-. Rheumatoid arthritis: Learn More – Fatigue related to rheumatoid arthritis. [Updated 2024 Jan 11].
https://www.ncbi.nlm.nih.gov/books/NBK384467/
712. Smolen JS, Landewé RBM, Bergstra SA, Kerschbaumer A, Sepriano A, Aletaha D, Caporali R, Edwards CJ, Hyrich KL, Pope JE, de Souza S, Stamm TA, Takeuchi T, Verschueren P, Winthrop KL, Balsa A, Bathon JM, Buch MH, Burmester GR, Buttgereit F, Cardiel MH, Chatzidionysiou K, Codreanu C, Cutolo M, den Broeder AA, El Aoufy K, Finckh A, Fonseca JE, Gottenberg JE, Haavardsholm EA, Iagnocco A, Lauper K, Li Z, McInnes IB, Mysler EF, Nash P, Poor G, Ristic GG, Rivellese F, Rubbert-Roth A, Schulze-Koops H, Stoilov N, Strangfeld A, van der Helm-van Mil A, van Duuren E, Vliet Vlieland TPM, Westhovens R, van der Heijde D. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update. Ann Rheum Dis. 2023 Jan;82(1):3-18. doi: 10.1136/ard-2022-223356. Epub 2022 Nov 10. Erratum in: Ann Rheum Dis. 2023 Mar;82(3):e76. doi: 10.1136/ard-2022-223356corr1. PMID: 36357155.
https://pubmed.ncbi.nlm.nih.gov/36357155/
713. Mohamed H. Babiker-Mohamed, Sambhawana Bhandari, Prabha Ranganathan, Pharmacogenetics of therapies in rheumatoid arthritis: An update, Best Practice & Research Clinical Rheumatology, Volume 38, Issue 4, 2024, 101974, ISSN 1521-6942, https://doi.org/10.1016/j.berh.2024.101974.
https://www.sciencedirect.com/science/article/pii/S1521694224000457
714. Shakeel, Laiba MBBSa; Shaukat, Ayesha MBBSa; Khaliq, Nawal MBBSa; Kashif, Aayat MBBSb; Mujeeb, Azka MBBSb; Adnan, Zahabia MBBSb; Taj, Javeria MBBSa; Akilimali, Aymar MDc. Rheumatoid arthritis: a comprehensive overview of genetic markers, emerging therapies, and personalized medicine. Annals of Medicine & Surgery 87(2):p 696-710, February 2025. | DOI: 10.1097/MS9.0000000000002890
https://journals.lww.com/annals-of-medicine-and-surgery/fulltext/2025/02000/rheumatoid_arthritis__a_comprehensive_overview_of.35.aspx
715. Hoenders R, Ghelman R, Portella C, Simmons S, Locke A, Cramer H, Gallego-Perez D, Jong M. A review of the WHO strategy on traditional, complementary, and integrative medicine from the perspective of academic consortia for integrative medicine and health. Front Med (Lausanne). 2024 Jun 11;11:1395698. doi: 10.3389/fmed.2024.1395698. PMID: 38933107; PMCID: PMC11201178.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11201178/
716. Integrating Traditional Medicine in Health Care 30 January 2023, WHO
https://www.who.int/southeastasia/news/feature-stories/detail/integrating-traditional-medicine
717. Prasad S, Aggarwal BB. Turmeric, the Golden Spice: From Traditional Medicine to Modern Medicine. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 13.
https://www.ncbi.nlm.nih.gov/books/NBK92752/
718. Plant-Based Drugs and Medicines, Dr. Liji Thomas, MDBy Dr. Liji Thomas, MD, Reviewed by Emily Henderson, B.Sc., News-Medical.net
https://www.news-medical.net/health/Plant-Based-Drugs-and-Medicines.aspx
719. Chaachouay, N.; Zidane, L. Plant-Derived Natural Products: A Source for Drug Discovery and Development. Drugs Drug Candidates 2024, 3, 184-207. https://doi.org/10.3390/ddc3010011
https://www.mdpi.com/2813-2998/3/1/11
720. Victoria P (2023) Utilizing the Healing Power of Medicinal Plants. Med Aromat Plant. 12:456
https://www.longdom.org/open-access/utilizing-the-healing-power-of-medicinal-plants-103632.html
721. Wachtel-Galor S, Benzie IFF. Herbal Medicine: An Introduction to Its History, Usage, Regulation, Current Trends, and Research Needs. In: Benzie IFF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition. Boca Raton (FL): CRC Press/Taylor & Francis; 2011. Chapter 1.
https://www.ncbi.nlm.nih.gov/books/NBK92773/
722. integrative medicine, National Cancer Institute
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/integrative-medicine
723. GBD 2017 Diet Collaborators. Health effects of dietary risks in 195 countries, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2019 May 11;393(10184):1958-1972. doi: 10.1016/S0140-6736(19)30041-8. Epub 2019 Apr 4. Erratum in: Lancet. 2021 Jun 26;397(10293):2466. PMID: 30954305; PMCID: PMC6899507.
https://www.thelancet.com/article/S0140-6736(19)30041-8/fulltext
724. US Burden of Disease Collaborators, Mokdad AH, Ballestros K, et al. The State of US Health, 1990-2016: Burden of Diseases, Injuries, and Risk Factors Among US States. JAMA. 2018 Apr;319(14):1444-1472. DOI: 10.1001/jama.2018.0158. PMID: 29634829; PMCID: PMC5933332.
https://europepmc.org/article/MED/29634829
725. Why Good Nutrition is Important, Center for Science in the Public Interest
https://www.cspinet.org/eating-healthy/why-good-nutrition-important
726. Kaczorowski J, Campbell NR, Duhaney T, Mang E, Gelfer M. Reducing deaths by diet: Call to action for a public policy agenda for chronic disease prevention. Can Fam Physician. 2016 Jun;62(6):469-70. PMID: 27302998; PMCID: PMC4907549.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4907549/
727. Bad diets responsible for 11 million premature deaths globally per year, 08th April 2019, The NCD Alliance
https://ncdalliance.org/news-events/news/bad-diets-responsible-for-11-million-premature-deaths-globally-per-year
728. DeeDee Stiepan Mayo Clinic Minute: Relationship between food, disease stronger than you may think January 30, 2023
https://newsnetwork.mayoclinic.org/discussion/mayo-clinic-minute-mayo-clinic-minute-relationship-between-food-disease-stronger-than-you-may-think/
729. Wang DD, Li Y, Afshin A, Springmann M, Mozaffarian D, Stampfer MJ, Hu FB, Murray CJL, Willett WC. Global Improvement in Dietary Quality Could Lead to Substantial Reduction in Premature Death. J Nutr. 2019 Jun 1;149(6):1065-1074. doi: 10.1093/jn/nxz010. PMID: 31049577; PMCID: PMC6543201.
https://www.sciencedirect.com/science/article/pii/S0022316622166307
730. May 19, 2021 / Nutrition A Poor Diet Increases Your Risk of Dying from Heart Disease, Stroke, Diabetes, Cleveland Clinic
https://health.clevelandclinic.org/a-poor-diet-increases-your-risk-of-dying-from-heart-disease-stroke-diabetes/
731. Akbar Rijia, Raman Krishnamoorthi, Muthuramalingam Kaviyadharshini, Pambayan Ulagan Mahalingam, Unlocking fungal fortunes: Cutting-edge extraction techniques and therapeutic possibilities of mushroom bioactive compounds, Food Chemistry Advances, Volume 6, 2025, 100895, ISSN 2772-753X, https://doi.org/10.1016/j.focha.2025.100895.
https://www.sciencedirect.com/science/article/pii/S2772753X25000115
732. Singh, A.; Saini, R.K.; Kumar, A.; Chawla, P.; Kaushik, R. Mushrooms as Nutritional Powerhouses: A Review of Their Bioactive Compounds, Health Benefits, and Value-Added Products. Foods 2025, 14, 741. https://doi.org/10.3390/foods14050741
https://www.mdpi.com/2304-8158/14/5/741
733. Yadav SK, Ir R, Jeewon R, Doble M, Hyde KD, Kaliappan I, Jeyaraman R, Reddi RN, Krishnan J, Li M, Durairajan SSK. A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders. Planta Med. 2020 Nov;86(16):1161-1175. doi: 10.1055/a-1177-4834. Epub 2020 Jul 14. PMID: 32663897.
https://www.thieme-connect.com/products/ejournals/abstract/10.1055/a-1177-4834
734. Rašeta M, Popović M, Knežević P, Šibul F, Kaišarević S, Karaman M. Bioactive Phenolic Compounds of Two Medicinal Mushroom Species Trametes versicolor and Stereum subtomentosum as Antioxidant and Antiproliferative Agents. Chem Biodivers. 2020 Dec;17(12):e2000683. doi: 10.1002/cbdv.202000683. Epub 2020 Nov 17. PMID: 33058392.
https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202000683
735. Venturella, G.; Ferraro, V.; Cirlincione, F.; Gargano, M.L. Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials. Int. J. Mol. Sci. 2021, 22, 634. https://doi.org/10.3390/ijms22020634
https://www.mdpi.com/1422-0067/22/2/634
736. Shaffique, S.; Kang, S.-M.; Kim, A.-Y.; Imran, M.; Aaqil Khan, M.; Lee, I.-J. Current Knowledge of Medicinal Mushrooms Related to Anti-Oxidant Properties. Sustainability 2021, 13, 7948. https://doi.org/10.3390/su13147948
https://www.mdpi.com/2071-1050/13/14/7948
737. Hetland G, Johnson E, Bernardshaw SV, Grinde B. Can medicinal mushrooms have prophylactic or therapeutic effect against COVID-19 and its pneumonic superinfection and complicating inflammation? Scand J Immunol. 2021 Jan;93(1):e12937. doi: 10.1111/sji.12937. Epub 2020 Jul 29. PMID: 32657436; PMCID: PMC7404338.
https://onlinelibrary.wiley.com/doi/10.1111/sji.12937
738. Arthritis drug found in mushrooms, Nina Athey-Pollard, Royal Society of Chemistry
https://www.rsc.org/news/2005/july/arthritis-drug-found-in-mushrooms
739. Dennett CC, Simon J. The role of polycystic ovary syndrome in reproductive and metabolic health: overview and approaches for treatment. Diabetes Spectr. 2015 May;28(2):116-20. doi: 10.2337/diaspect.28.2.116. PMID: 25987810; PMCID: PMC4433074.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4433074/
740. May 15, 2024, Diabetes and Polycystic Ovary Syndrome (PCOS), u.s. centers for disease control and prevention
https://www.cdc.gov/diabetes/risk-factors/pcos-polycystic-ovary-syndrome.html
741. Scicchitano P, Dentamaro I, Carbonara R, Bulzis G, Dachille A, Caputo P, Riccardi R, Locorotondo M, Mandurino C, Matteo Ciccone M. Cardiovascular Risk in Women With PCOS. Int J Endocrinol Metab. 2012 Fall;10(4):611-8. doi: 10.5812/ijem.4020. Epub 2012 Sep 30. PMID: 23843832; PMCID: PMC3693634.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3693634/
742. Bishop KS, Kao CH, Xu Y, Glucina MP, Paterson RR, Ferguson LR. From 2000years of Ganoderma lucidum to recent developments in nutraceuticals. Phytochemistry. 2015 Jun;114:56-65. doi: 10.1016/j.phytochem.2015.02.015. Epub 2015 Mar 17. PMID: 25794896.
https://pubmed.ncbi.nlm.nih.gov/25794896/
743. Oke MA, Afolabi FJ, Oyeleke OO, Kilani TA, Adeosun AR, Olanbiwoninu AA and Adebayo EA (2022) Ganoderma lucidum: Unutilized natural medicine and promising future solution to emerging diseases in Africa. Front. Pharmacol. 13:952027. doi: 10.3389/fphar.2022.952027
https://www.frontiersin.org/articles/10.3389/fphar.2022.952027/full
744. Grienke U, Kaserer T, Pfluger F, et al. Accessing biological actions of Ganoderma secondary metabolites by in silico profiling. Phytochemistry. 2015 Jun;114:114-124. DOI: 10.1016/j.phytochem.2014.10.010. PMID: 25457486; PMCID: PMC4948669.
https://europepmc.org/article/MED/25457486
745. El Sheikha AF. Nutritional Profile and Health Benefits of Ganoderma lucidum "Lingzhi, Reishi, or Mannentake" as Functional Foods: Current Scenario and Future Perspectives. Foods. 2022 Apr 1;11(7):1030. doi: 10.3390/foods11071030. PMID: 35407117; PMCID: PMC8998036.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8998036/
746. Ahmad MF, Ahmad FA, Khan MI, Alsayegh AA, Wahab S, Alam MI, Ahmed F. Ganoderma lucidum: A potential source to surmount viral infections through β-glucans immunomodulatory and triterpenoids antiviral properties. Int J Biol Macromol. 2021 Sep 30;187:769-779. doi: 10.1016/j.ijbiomac.2021.06.122. Epub 2021 Jun 29. PMID: 34197853.
https://pubmed.ncbi.nlm.nih.gov/34197853/
747. Saltarelli R, Palma F, Gioacchini AM, Calcabrini C, Mancini U, De Bellis R, Stocchi V, Potenza L. Phytochemical composition, antioxidant and antiproliferative activities and effects on nuclear DNA of ethanolic extract from an Italian mycelial isolate of Ganoderma lucidum. J Ethnopharmacol. 2019 Mar 1;231:464-473. doi: 10.1016/j.jep.2018.11.041. Epub 2018 Dec 1. PMID: 30513345.
https://pubmed.ncbi.nlm.nih.gov/30513345/
748. Anticancer Agents Med Chem. Author manuscript; available in PMC 2019 Jul 12. Published in final edited form as: Anticancer Agents Med Chem. 2018; 18(5): 667–674. Ganoderma lucidum Polysaccharides as an anti-cancer agent Didem Sohretoglu1,2 and Shile Huang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624854/
749. Ahmad MF, A Alsayegh A, Ahmad FA, Akhtar MS, Alavudeen SS, Bantun F, Wahab S, Ahmed A, Ali M, Elbendary EY, Raposo A, Kambal N, H Abdelrahman M. Ganoderma lucidum: Insight into antimicrobial and antioxidant properties with development of secondary metabolites. Heliyon. 2024 Feb 4;10(3):e25607. doi: 10.1016/j.heliyon.2024.e25607. PMID: 38356540; PMCID: PMC10865332.
https://www.sciencedirect.com/science/article/pii/S2405844024016384
750. Exp Ther Med. 2017 Oct;14(4):3273-3278. doi: 10.3892/etm.2017.4883. Epub 2017 Aug 3. Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors. Zheng DS1, Chen LS2.
https://pubmed.ncbi.nlm.nih.gov/28912878/
751. Valverde ME, Hernández-Pérez T, Paredes-López O. Edible mushrooms: improving human health and promoting quality life. Int J Microbiol. 2015;2015:376387. doi: 10.1155/2015/376387. Epub 2015 Jan 20. PMID: 25685150; PMCID: PMC4320875.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4320875/
752. Γρίπη και Εποχική Γρίπη, ΕΟΔΥ.
https://eody.gov.gr/disease/gripi-kai-epochiki-gripi/
753. The Flu: 3 Ways to Fight Back at 50-Plus, The Johns Hopkins University
https://www.hopkinsmedicine.org/health/conditions-and-diseases/influenza/the-flu-3-ways-to-fight-back-at-50-plus
754. Strengthen your immune system against seasonal illnesses December 17, 2024 Teresa Saenz
https://vitalrecord.tamu.edu/strengthen-your-immune-system-against-seasonal-illnesses
755. Allen EK, Thomas PG. Immunity to influenza. Preventing infection and regulating disease. Am J Respir Crit Care Med. 2015 Feb 1;191(3):248-51. doi: 10.1164/rccm.201412-2245ED. PMID: 25635487; PMCID: PMC4351582.
https://www.atsjournals.org/doi/full/10.1164/rccm.201412-2245ED
756. Zhang, Y.; Zhang, G.; Ling, J. Medicinal Fungi with Antiviral Effect. Molecules 2022, 27, 4457. https://doi.org/10.3390/molecules27144457
https://www.mdpi.com/1420-3049/27/14/4457
757. Medicinal Mushrooms: Fitness for Your Immune System, Aviva Romm, MD
https://avivaromm.com/medicinal-mushrooms-immune-system/
758. Manash Pratim Pathak, Kalyani Pathak, Riya Saikia, Urvashee Gogoi, Mohammad Zaki Ahmad, Pompy Patowary, Aparoop Das, Immunomodulatory effect of mushrooms and their bioactive compounds in cancer: A comprehensive review, Biomedicine & Pharmacotherapy, Volume 149, 2022, 112901, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2022.112901.
https://www.sciencedirect.com/science/article/pii/S0753332222002906
759. Vlasenko, Vyacheslav & Vlasenko, Anastasia & Turmunkh, Dejidmaa & Dondov, Budsuren. (2021). First Data on Antiviral Activity of Aqueous Extracts from Medicinal Mushrooms from the Altai Mountains in Russia against Influenza Virus Type A. International Journal of Medicinal Mushrooms. 23. 37-45.
https://www.researchgate.net/publication/356811510_First_Data_on_Antiviral_Activity_of_Aqueous_Extracts_from_Medicinal_Mushrooms_from_the_Altai_Mountains_in_Russia_against_Influenza_Virus_Type_A
760. Arunachalam K, Sasidharan SP, Yang X. A concise review of mushrooms antiviral and immunomodulatory properties that may combat against COVID-19. Food Chem Adv. 2022 Oct;1:100023. doi: 10.1016/j.focha.2022.100023. Epub 2022 Mar 2. PMID: 36686330; PMCID: PMC8887958.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8887958/
761. Seo DJ, Choi C. Antiviral Bioactive Compounds of Mushrooms and Their Antiviral Mechanisms: A Review. Viruses. 2021 Feb 23;13(2):350. doi: 10.3390/v13020350. PMID: 33672228; PMCID: PMC7926341.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7926341/
762. News New discovery could help protect against influenza, McGill University, 18/2/25
https://www.mcgill.ca/newsroom/channels/news/new-discovery-could-help-protect-against-influenza-363625
763. Hetland G, Johnson E, Bernardshaw SV, Grinde B. Can medicinal mushrooms have prophylactic or therapeutic effect against COVID-19 and its pneumonic superinfection and complicating inflammation?. Scand J Immunol. 2021; 93:e12937. https://doi.org/10.1111/sji.12937
https://onlinelibrary.wiley.com/doi/10.1111/sji.12937
764. MS Patient’s Pick of the Week’s News: Remyelination, Ocrevus, Mushrooms, Heparin, Exercise admin avatar by admin | October 17, 2016
https://multiplesclerosisnewstoday.com/ians-blog/2016/10/17/ms-patients-pick-weeks-news-remyelination-ocrevus-mushrooms-heparin-exercise/
765. Pourmohammadi G, Moghimi H. New approach of using medicinal mushrooms for managing and curing multiple sclerosis. Fitoterapia. 2025 Sep;185:106684. doi: 10.1016/j.fitote.2025.106684. Epub 2025 Jun 15. PMID: 40527388.
https://pubmed.ncbi.nlm.nih.gov/40527388/
766. Wang R, Sun H, Yang T, Xu J. Causal relationship between hypertension and risk of constipation: A 2-way 2-sample Mendelian randomization study. Medicine (Baltimore). 2024 May 3;103(18):e38057. doi: 10.1097/MD.0000000000038057. PMID: 38701266; PMCID: PMC11062663.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11062663/
767. Wang, Junwen, Ye, Yuyang, Chen, Xuefeng, Hu, Xinru, Peng, Yong, Constipation and Cardiovascular Mortality Risk in Patients With Hypertension: A Long-Term Cohort Study, International Journal of Hypertension, 2025, 9921027, 9 pages, 2025. https://doi.org/10.1155/ijhy/9921027
https://onlinelibrary.wiley.com/doi/10.1155/ijhy/9921027
768. Sumida K, Molnar MZ, Potukuchi PK, Thomas F, Lu JL, Yamagata K, Kalantar-Zadeh K, Kovesdy CP. Constipation and risk of death and cardiovascular events. Atherosclerosis. 2019 Feb;281:114-120. doi: 10.1016/j.atherosclerosis.2018.12.021. Epub 2018 Dec 23. PMID: 30658186; PMCID: PMC6399019.https://pmc.ncbi.nlm.nih.gov/articles/PMC6399019/
769. Liu B, Wu X, Wang Y, Hu X. Association between constipation and risk of cardiovascular or all-cause mortality: a meta-analysis. Ann Med. 2025 Dec;57(1):2561803. doi: 10.1080/07853890.2025.2561803. Epub 2025 Sep 22. PMID: 40982729; PMCID: PMC12456042.
https://pubmed.ncbi.nlm.nih.gov/40982729/
770. Biedroń, Rafał & Tangen, Jon-Magnus & Maresz, Katarzyna & Hetland, Geir. (2012). Agaricus blazei Murill - immunomodulatory properties and health benefits. Funct Foods Health Dis. 2. 428-447. 10.31989/ffhd.v2i11.72.
https://ffhdj.com/index.php/ffhd/article/view/72/162
771. TianX, Lun Z, Ito J.Clinical observation on treatment of acute non lymphocytic leukemia with Agaricus blazei. Lanzhou Med Coll 1994;20:169–171.
https://www.springboard4health.com/notebook/health_agaricus_6.html
772. Υπουργείο Αγροτικής Ανάπτυξης και Τροφίμων, Γενική Διεύθυνση Φυτικής Παραγωγής, Μανιτάρια
https://www.minagric.gr/images/stories/docs/agrotis/Aromatika_Fyta/Manitari_entypo_291211.pdf
773. Υπουργείο Παιδείας, Θρησκευμάτων και Αθλητισμού, Τριπτόλεμος, Πρόγραμμα,
https://www.minedu.gov.gr/publications/docs2016/250416_programms-endodima-manitaria.pdf
774. ΕΛΓΟ-ΔΗΜΗΤΡΑ: ΙΝΣΤΙΤΟΥΤΟ ΤΕΧΝΟΛΟΓΙΑΣ ΓΕΩΡΓΙΚΩΝ ΠΡΟΪΟΝΤΩΝ, ΕΡΓΑΣΤΗΡΙΟ ΕΔΩΔΙΜΩΝ & ΦΑΡΜΑΚΕΥΤΙΚΩΝ ΜΥΚΗΤΩΝ, Δρ. Αντώνης Φιλιππούσης Γεωπόνος - Μυκητολόγος Τακτικός Ερευνητής
https://www.e-kyklades.gr/images/10Epistrofi_Filippoysis_F29952.pdf
775. Uffelman CN, Doenges KA, Armstrong ML, Quinn K, Reisdorph RM, Tang M, Krebs NF, Reisdorph NA, Campbell WW. Metabolomics Profiling of White Button, Crimini, Portabella, Lion's Mane, Maitake, Oyster, and Shiitake Mushrooms Using Untargeted Metabolomics and Targeted Amino Acid Analysis. Foods. 2023 Aug 8;12(16):2985. doi: 10.3390/foods12162985. PMID: 37627983; PMCID: PMC10453450.
https://pubmed.ncbi.nlm.nih.gov/37627983/
Προσαρμογόνα
1. Chugh RM, Mittal P, Mp N, Arora T, Bhattacharya T, Chopra H, Cavalu S, Gautam RK. Fungal Mushrooms: A Natural Compound With Therapeutic Applications. Front Pharmacol. 2022 Jul 13;13:925387. doi: 10.3389/fphar.2022.925387. PMID: 35910346; PMCID: PMC9328747.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9328747/
2. Adaptogenic or Medicinal Mushrooms, Published April 20, 2009, M. Saljoughian, PharmD, PhD Alta Bates Summit Medical Center Department of Pharmacy Services Berkeley, California,
https://www.uspharmacist.com/article/adaptogenic-or-medicinal-mushrooms
3. Adaptogens, Cleveland Clinic, Last reviewed on 02/10/2022.
https://my.clevelandclinic.org/health/drugs/22361-adaptogens
4. What are adaptogens and should you be taking them? February 16, 2022 By uclahealth,
https://www.uclahealth.org/news/article/what-are-adaptogens-and-should-you-be-taking-them
5. Medicinal Mushrooms and their history of therapeutic uses, Sophie Barrett, Medical Herbalist, Naturopath, Faculty of Homeopathy
https://www.facultyofhomeopathy.org/events/medicinal-mushrooms-their-history-of-therapeutic-uses
6. Bocharova OA. Adaptogeny kak sredstva profilakticheskoĭ onkologii [Adaptogens as agents for prophylactic oncology]. Vestn Ross Akad Med Nauk. 1999;(5):49-53. Russian. PMID: 10394302.
https://pubmed.ncbi.nlm.nih.gov/10394302/
7. Panossian A, Wikman G, Kaur P, Asea A. Adaptogens exert a stress-protective effect by modulation of expression of molecular chaperones. Phytomedicine. 2009 Jun;16(6-7):617-22. doi: 10.1016/j.phymed.2008.12.003. Epub 2009 Feb 1. PMID: 19188053.
https://pubmed.ncbi.nlm.nih.gov/19188053
8. Khanum F, Bawa AS, Singh B. Rhodiola rosea: A Versatile Adaptogen. Compr Rev Food Sci Food Saf. 2005 Jul;4(3):55-62. doi: 10.1111/j.1541-4337.2005.tb00073.x. PMID: 33430554.
https://pubmed.ncbi.nlm.nih.gov/33430554/
9. Blyumin-Karasik M, Colon J, Nguyen S, Rosen J. Laser and Skin-Care Synergy: A Post-Laser Application of Novel Adaptogenic Moisturizing Serum for Improving Healing and Cosmesis on the Face. J Cosmet Dermatol. 2024 Nov 6. doi: 10.1111/jocd.16668. Epub ahead of print. PMID: 39503217.
https://pubmed.ncbi.nlm.nih.gov/39503217/
10. Liu XX, Chen CY, Li L, Guo MM, He YF, Meng H, Dong YM, Xiao PG, Yi F. Bibliometric Study of Adaptogens in Dermatology: Pharmacophylogeny, Phytochemistry, and Pharmacological Mechanisms. Drug Des Devel Ther. 2023 Feb 6;17:341-361. doi: 10.2147/DDDT.S395256. PMID: 36776447; PMCID: PMC9912821.
https://pubmed.ncbi.nlm.nih.gov/36776447/
11. KrishnaRaju AV, Somepalli V, Thanawala S, Shah R. Efficacy and Anti-Inflammatory Activity of Ashwagandha Sustained-Release Formulation on Depression and Anxiety Induced by Chronic Unpredictable Stress: in vivo and in vitro Studies. J Exp Pharmacol. 2023 Jul 25;15:291-305. doi: 10.2147/JEP.S407906. PMID: 37521489; PMCID: PMC10386834.
https://pubmed.ncbi.nlm.nih.gov/37521489/
12. Chandrasekhar K, Kapoor J, Anishetty S. A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults. Indian J Psychol Med. 2012 Jul;34(3):255-62. doi: 10.4103/0253-7176.106022. PMID: 23439798; PMCID: PMC3573577.
https://pubmed.ncbi.nlm.nih.gov/23439798/
13. Okoh L, Ajayi AM, Ben-Azu B, Akinluyi ET, Emokpae O, Umukoro S. D-Ribose-L-cysteine exhibits adaptogenic-like activity through inhibition of oxido-inflammatory responses and increased neuronal caspase-3 activity in mice exposed to unpredictable chronic mild stress. Mol Biol Rep. 2020 Oct;47(10):7709-7722. doi: 10.1007/s11033-020-05845-1. Epub 2020 Sep 21. PMID: 32959196.
https://pubmed.ncbi.nlm.nih.gov/32959196/
14. Wróbel-Biedrawa D, Podolak I. Anti-Neuroinflammatory Effects of Adaptogens: A Mini-Review. Molecules. 2024 Feb 15;29(4):866. doi: 10.3390/molecules29040866. PMID: 38398618; PMCID: PMC10891670.
https://pubmed.ncbi.nlm.nih.gov/38398618/
15. Panossian A. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals. Ann N Y Acad Sci. 2017 Aug;1401(1):49-64. doi: 10.1111/nyas.13399. Epub 2017 Jun 22. PMID: 28640972.
https://pubmed.ncbi.nlm.nih.gov/28640972
16. Thakur, Dr. Ajit & Chatterjee, Shyam & Kumar, Vikas. (2014). Andrographolides and traditionally used Andrographis paniculata as potential adaptogens: Implications for therapeutic innovation. TANG (Humanitas Medicine). 4. 15.1-15.14. 10.5667/tang.2014.0002.
https://www.researchgate.net/publication/269577319_Andrographolides_and_traditionally_used_Andrographis_paniculata_as_potential_adaptogens_Implications_for_therapeutic_innovation
1. Panossian, Alexander & H, Wagener. (2011). Adaptogens. A Review of their History, Biological Activity, and Clinical Benefits.. Herbal Gram. 90.
https://www.researchgate.net/publication/236462312_Adaptogens_A_Review_of_their_History_Biological_Activity_and_Clinical_Benefits/citation/download
2. A general Endobiogenic approach to regulation of the immune system Kamyar M. Hedayat, Jean-Claude Lapraz, in The Theory of Endobiogeny, 2019
https://www.sciencedirect.com/topics/medicine-and-dentistry/adaptogen
3. Panossian, A.; Wikman, G. Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress—Protective Activity. Pharmaceuticals 2010, 3, 188-224. https://doi.org/10.3390/ph3010188
https://www.mdpi.com/1424-8247/3/1/188
4. Liao LY, He YF, Li L, Meng H, Dong YM, Yi F, Xiao PG. A preliminary review of studies on adaptogens: comparison of their bioactivity in TCM with that of ginseng-like herbs used worldwide. Chin Med. 2018 Nov 16;13:57. doi: 10.1186/s13020-018-0214-9. PMID: 30479654; PMCID: PMC6240259.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240259/
5. Abate M, Pepe G, Randino R, Pisanti S, Basilicata MG, Covelli V, Bifulco M, Cabri W, D'Ursi AM, Campiglia P, Rodriquez M. Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury. Pharmaceuticals (Basel). 2020 Aug 29;13(9):224. doi: 10.3390/ph13090224. PMID: 32872510; PMCID: PMC7557611.
https://pubmed.ncbi.nlm.nih.gov/32872510/
6. Sagar SM, Yance D, Wong RK. Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 2. Curr Oncol. 2006 Jun;13(3):99-107. PMID: 17576449; PMCID: PMC1891180.
https://pubmed.ncbi.nlm.nih.gov/17576449/
7. Sagar SM, Yance D, Wong RK. Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 1. Curr Oncol. 2006 Feb;13(1):14-26. PMID: 17576437; PMCID: PMC1891166.
https://pubmed.ncbi.nlm.nih.gov/17576437/
8. Yance DR Jr, Sagar SM. Targeting angiogenesis with integrative cancer therapies. Integr Cancer Ther. 2006 Mar;5(1):9-29. doi: 10.1177/1534735405285562. PMID: 16484711.
https://pubmed.ncbi.nlm.nih.gov/16484711/
9. Panossian A. Understanding adaptogenic activity: specificity of the pharmacological action of adaptogens and other phytochemicals. Ann N Y Acad Sci. 2017 Aug;1401(1):49-64. doi: 10.1111/nyas.13399. Epub 2017 Jun 22. PMID: 28640972.
https://pubmed.ncbi.nlm.nih.gov/28640972/
10. Sulaiman MK, Lakshmanan J. Systemic and Anticancer Potential of Adaptogenic Constituents Isolated from Traditional Herbs - A Mini-Review. Anticancer Agents Med Chem. 2022 Aug 4;22(16):2811-2821. doi: 10.2174/1871520622666220408091610. PMID: 35400325.
https://pubmed.ncbi.nlm.nih.gov/35400325/
11. Kaur P, Robin, Makanjuola VO, Arora R, Singh B, Arora S. Immunopotentiating significance of conventionally used plant adaptogens as modulators in biochemical and molecular signalling pathways in cell mediated processes. Biomed Pharmacother. 2017 Nov;95:1815-1829. doi: 10.1016/j.biopha.2017.09.081. Epub 2017 Oct 6. PMID: 28968926.
https://pubmed.ncbi.nlm.nih.gov/28968926/
12. Seo EJ, Klauck SM, Efferth T, Panossian A. Adaptogens in chemobrain (Part I): Plant extracts attenuate cancer chemotherapy-induced cognitive impairment - Transcriptome-wide microarray profiles of neuroglia cells. Phytomedicine. 2019 Mar 1;55:80-91. doi: 10.1016/j.phymed.2018.10.022. Epub 2018 Oct 19. PMID: 30668446.
https://pubmed.ncbi.nlm.nih.gov/30668446/
13. Diwanay S, Gautam M, Patwardhan B. Cytoprotection and immunomodulation in cancer therapy. Curr Med Chem Anticancer Agents. 2004 Nov;4(6):479-90. doi: 10.2174/1568011043352704. PMID: 15579014.
https://pubmed.ncbi.nlm.nih.gov/15579014/
14. Seo EJ, Klauck SM, Efferth T, Panossian A. Adaptogens in chemobrain (Part III): Antitoxic effects of plant extracts towards cancer chemotherapy-induced toxicity - transcriptome-wide microarray analysis of neuroglia cells. Phytomedicine. 2019 Mar 15;56:246-260. doi: 10.1016/j.phymed.2018.11.011. Epub 2018 Nov 9. PMID: 30668345.
https://pubmed.ncbi.nlm.nih.gov/30668345/
15. Bocharova OA. Adaptogeny kak sredstva profilakticheskoĭ onkologii [Adaptogens as agents for prophylactic oncology]. Vestn Ross Akad Med Nauk. 1999;(5):49-53. Russian. PMID: 10394302.
https://pubmed.ncbi.nlm.nih.gov/10394302/
16. Panossian, A.; Wikman, G. Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress—Protective Activity. Pharmaceuticals 2010, 3, 188-224. https://doi.org/10.3390/ph3010188
https://www.mdpi.com/1424-8247/3/1/188
Ωμέγα 3
1. Fitsum, S., D. B.Sbhatu, and G.Gebreyohannes. 2025. “Harnessing the Nutritional Value, Therapeutic Applications, and Environmental Impact of Mushrooms.” Food Science & Nutrition13, no. 7: e70611. https://doi.org/10.1002/fsn3.70611.
https://onlinelibrary.wiley.com/doi/10.1002/fsn3.70611
2. Rui Yeong Tan, Zul Ilham, Wan Abd Al Qadr Imad Wan-Mohtar, Sarina Abdul Halim-Lim, Siti Rokhiyah Ahmad Usuldin, Rahayu Ahmad, Muhammad Adlim, Mushroom oils: A review of their production, composition, and potential applications, Heliyon, Volume 10, Issue 11, 2024, e31594, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2024.e31594.
https://www.sciencedirect.com/science/article/pii/S2405844024076254
3. Denise Sande, Geane Pereira de Oliveira, Marília Aparecida Fidelis e Moura, Bruna de Almeida Martins, Matheus Thomaz Nogueira Silva Lima, Jacqueline Aparecida Takahashi, Edible mushrooms as a ubiquitous source of essential fatty acids, Food Research International, Volume 125, 2019, 108524, ISSN 0963-9969, https://doi.org/10.1016/j.foodres.2019.108524.
https://www.sciencedirect.com/science/article/pii/S0963996919303953
4. Dimopoulou, M.; Kolonas, A.; Mourtakos, S.; Androutsos, O.; Gortzi, O. Nutritional Composition and Biological Properties of Sixteen Edible Mushroom Species. Appl. Sci. 2022, 12, 8074. https://doi.org/10.3390/app12168074
https://www.mdpi.com/2076-3417/12/16/8074
5. Gustavo Waltzer Fehrenbach, Robert Pogue, Frank Carter, Eoghan Clifford, Neil Rowan, Implications for the seafood industry, consumers and the environment arising from contamination of shellfish with pharmaceuticals, plastics and potentially toxic elements: A case study from Irish waters with a global orientation, Science of The Total Environment, Volume 844, 2022, 157067, ISSN 0048-9697, https://doi.org/10.1016/j.scitotenv.2022.157067.
https://www.sciencedirect.com/science/article/pii/S004896972204164X?via%3Dihub
Δισμουτάση του υπεροξειδίου
1. Xie, Y., Gu, Y., Li, Z. et al. Effects of exercise on different antioxidant enzymes and related indicators: a systematic review and meta-analysis of randomized controlled trials. Sci Rep 15, 12518 (2025). https://doi.org/10.1038/s41598-025-97101-4
https://www.nature.com/articles/s41598-025-97101-4
2. Zheng M, Liu Y, Zhang G, Yang Z, Xu W, Chen Q. The Applications and Mechanisms of Superoxide Dismutase in Medicine, Food, and Cosmetics. Antioxidants (Basel). 2023 Aug 27;12(9):1675. doi: 10.3390/antiox12091675. PMID: 37759978; PMCID: PMC10525108.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10525108/
3. Lei XG, Zhu JH, Cheng WH, Bao Y, Ho YS, Reddi AR, Holmgren A, Arnér ES. Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications. Physiol Rev. 2016 Jan;96(1):307-64. doi: 10.1152/physrev.00010.2014. PMID: 26681794; PMCID: PMC4839492.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4839492/
4. Xueqin Li, Xingqi Cao, Zhimin Ying, Guangtao Yang, Emiel O Hoogendijk, Zuyun Liu, Plasma superoxide dismutase activity in relation to disability in activities of daily living and objective physical functioning among Chinese older adults, Maturitas, Volume 161, 2022, Pages 12-17, ISSN 0378-5122, https://doi.org/10.1016/j.maturitas.2022.01.018.
https://www.sciencedirect.com/science/article/abs/pii/S0378512222000238
5. Research Article | Volume 15 Issue 5 (May, 2025) | Pages 789 - 792 Estimation Of Antioxidant Enzyme Levels in Individuals with Regular and Irregular Sleep Patterns Kalola Akshaybhai Ramjibhai 1 , Aghara Harshilkumar Arvindbhai 2 , Detroja Milan Yogeshbhai 2 , Bloch M Asfaq Firozbhai
https://healthcare-bulletin.co.uk/article/estimation-of-antioxidant-enzyme-levels-in-individuals-with-regular-and-irregular-sleep-patterns-3482/
6. Segal, Lauren M. and Wilson, Richard A., "Reactive oxygen species metabolism and plant-fungal interactions" (2018). Papers in Plant Pathology. 573. https://digitalcommons.unl.edu/plantpathpapers/573
7. Buettner GR, Ng CF, Wang M, Rodgers VG, Schafer FQ. A new paradigm: manganese superoxide dismutase influences the production of H2O2 in cells and thereby their biological state. Free Radic Biol Med. 2006 Oct 15;41(8):1338-50. doi: 10.1016/j.freeradbiomed.2006.07.015. Epub 2006 Jul 21. PMID: 17015180; PMCID: PMC2443724.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2443724/
8. Aaron C. Asensio, Miriam Gil-Monreal, Laura Pires, Yolanda Gogorcena, Pedro María Aparicio-Tejo, Jose Fernando Moran, Two Fe-superoxide dismutase families respond differently to stress and senescence in legumes, Journal of Plant Physiology, Volume 169, Issue 13, 2012, Pages 1253-1260, ISSN 0176-1617, https://doi.org/10.1016/j.jplph.2012.04.019.
https://www.sciencedirect.com/science/article/abs/pii/S0176161712002398
9. Ismy, J., Sugandi, S., Rachmadi, D., Hardjowijoto, S., & Mustafa, A. (2020). The Effect of Exogenous Superoxide Dismutase (SOD) on Caspase-3 Activation and Apoptosis Induction in Pc-3 Prostate Cancer Cells. Research and Reports in Urology, 12, 503–508. https://doi.org/10.2147/RRU.S271203
https://www.tandfonline.com/doi/full/10.2147/RRU.S271203#d1e272
10. I. Rahman, S.K. Biswas, OXIDANTS AND ANTIOXIDANTS | Antioxidants, Enzymatic, Editor(s): Geoffrey J. Laurent, Steven D. Shapiro, Encyclopedia of Respiratory Medicine, Academic Press, 2006, Pages 258-266, ISBN 9780123708793, https://doi.org/10.1016/B0-12-370879-6/00283-0.
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/superoxide-dismutase
11. Ighodaro, O. M., & Akinloye, O. A. (2018). First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid. Alexandria Journal of Medicine, 54(4), 287–293. https://doi.org/10.1016/j.ajme.2017.09.001
https://www.tandfonline.com/doi/full/10.1016/j.ajme.2017.09.001#d1e515
12. Monday, July 24, 2023, Superoxide Dismutase Purported Benefits, Side Effects & More, Memorial Sloan Kettering Cancer Center
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/superoxide-dismutase
13. Dreyer, B.H. and Schippers, J.H.M. (2019). Copper-Zinc Superoxide Dismutases in Plants: Evolution, Enzymatic Properties, and Beyond. In Annual Plant Reviews online, J.A. Roberts (Ed.). https://doi.org/10.1002/9781119312994.apr0705
https://onlinelibrary.wiley.com/doi/10.1002/9781119312994.apr0705
14. Gopal RK, Elumalai S (2017) Industrial Production of Superoxide Dismutase (SOD): A Mini Review. J Prob Health 5:179.
https://www.longdom.org/open-access/industrial-production-of-superoxide-dismutase-sod-a-mini-review-36663.html
15. Geng, Ping, Siu, Ka-Chai, Wang, Zhaomei, Wu, Jian-Yong, Antifatigue Functions and Mechanisms of Edible and Medicinal Mushrooms, BioMed Research International, 2017, 9648496, 16 pages, 2017. https://doi.org/10.1155/2017/9648496
https://onlinelibrary.wiley.com/doi/10.1155/2017/9648496
16. Venturella G, Ferraro V, Cirlincione F, Gargano ML. Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials. Int J Mol Sci. 2021 Jan 10;22(2):634. doi: 10.3390/ijms22020634. PMID: 33435246; PMCID: PMC7826851.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7826851/
17. Kim MY, Seguin P, Ahn JK, Kim JJ, Chun SC, Kim EH, Seo SH, Kang EY, Kim SL, Park YJ, Ro HM, Chung IM. Phenolic compound concentration and antioxidant activities of edible and medicinal mushrooms from Korea. J Agric Food Chem. 2008 Aug 27;56(16):7265-70. doi: 10.1021/jf8008553. Epub 2008 Jul 11. PMID: 18616260.
https://pubs.acs.org/doi/10.1021/jf8008553
18. Guang Yu Cheng, Jun Liu, Ming Xuan Tao, Chang Mei Lu, Guo Rong Wu, Activity, thermostability and isozymes of superoxide dismutase in 17 edible mushrooms, Journal of Food Composition and Analysis, Volume 26, Issues 1–2, 2012, Pages 136-143, ISSN 0889-1575, https://doi.org/10.1016/j.jfca.2012.01.001.
https://www.sciencedirect.com/science/article/abs/pii/S0889157512000142
19. Aritson Cruz, Lígia Pimentel, Luis M. Rodríguez-Alcalá, Tito Fernandes, Manuela Pintado. Health Benefits of Edible Mushrooms Focused on Coriolus versicolor: A Review. Journal of Food and Nutrition Research. Vol. 4, No. 12, 2016, pp 773-781. https://pubs.sciepub.com/jfnr/4/12/2
https://ciencia.ucp.pt/ws/files/120409009/49220515.pdf
20. Emma Camilleri, Renald Blundell, Bikash Baral, Tomasz M. Karpinski, Edlira Aruci, Omar M. Atrooz, A brief overview of the medicinal and nutraceutical importance of Inonotus obliquus (chaga) mushrooms, Heliyon, Volume 10, Issue 15, 2024, e35638, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2024.e35638.
https://www.sciencedirect.com/science/article/pii/S2405844024116696
21. Mircea, Cosmin & Cioanca, Oana & Bild, Veronica & Iancu, C. & Stan, Catalina & Hancianu, Monica. (2018). In vivo antioxidant properties of some mushroom extracts in experimentally induced diabetes. Farmacia. 66. 257-261.
https://farmaciajournal.com/arhiva/201802/art-09-Mircea_Cioanca_Hancianu_257-261.pdf
22. Podkowa, A., Kryczyk-Poprawa, A., Opoka, W. et al. Culinary–medicinal mushrooms: a review of organic compounds and bioelements with antioxidant activity. Eur Food Res Technol 247, 513–533 (2021). https://doi.org/10.1007/s00217-020-03646-1
https://link.springer.com/article/10.1007/s00217-020-03646-1
23. Pigoń-Zając, D.; Małecka-Massalska, T.; Łapiński, J.; Prendecka-Wróbel, M. Modern Pro-Health Applications of Medicinal Mushrooms: Insights into the Polyporaceae Family, with a Focus on Cerrena unicolor. Molecules 2025, 30, 4089. https://doi.org/10.3390/molecules30204089
https://www.mdpi.com/1420-3049/30/20/4089
24. Itrat, Nizwa & Hasanath, Seinul & Ali, Akhtar. (2025). Mushrooms as Natural Antioxidants and Their Role in Oxidative Stress Management. 10.1007/978-3-032-00789-6_3.
https://www.researchgate.net/publication/396047472_Mushrooms_as_Natural_Antioxidants_and_Their_Role_in_Oxidative_Stress_Management
25. Luo J, Ganesan K, Xu B. Unlocking the Power: New Insights into the Anti-Aging Properties of Mushrooms. J Fungi (Basel). 2024 Mar 14;10(3):215. doi: 10.3390/jof10030215. PMID: 38535223; PMCID: PMC10970926.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10970926/
26. Zhang, J.-J.; Li, Y.; Zhou, T.; Xu, D.-P.; Zhang, P.; Li, S.; Li, H.-B. Bioactivities and Health Benefits of Mushrooms Mainly from China. Molecules 2016, 21, 938. https://doi.org/10.3390/molecules21070938
https://www.mdpi.com/1420-3049/21/7/938
27. ASHD 2020;19(1):27-35 2020 Ankara Üniversitesi Araştırma Makalesi/Research Article ISSN: 2667-6044 27 Biochemical evaluation of commercially available Reishi Supplement Against The Enzymes On Oxidation And Phosphorylation of Cellular Proteins. Fırat Ayan; Beste C. Bilen*; Belgin S. İşgör
https://dergipark.org.tr/en/download/article-file/1481711
28. Dharmasanti, Olivia & Iswar, Ida & Praharsini, IGAA & Muliarta, I & Widianti, I & Wahyuniari, Ida. (2023). Shiitake Mushroom Extract (Lentinus Edodes) Increases Superoxide Dismutase Levels and Collagen Quantity in Male Wistar Strain Rats (Rattus Norvegicus) Exposed to Ultraviolet B Light. International Journal of Research Publication and Reviews. 4. 1550-1555. 10.55248/gengpi.4.923.92447.
https://www.researchgate.net/publication/374343555_Shiitake_Mushroom_Extract_Lentinus_Edodes_Increases_Superoxide_Dismutase_Levels_and_Collagen_Quantity_in_Male_Wistar_Strain_Rats_Rattus_Norvegicus_Exposed_to_Ultraviolet_B_Light
29. Choi, Se-Jin & Lee, Yeon-Sil & Kim, Jin-Kyung & Kim, Jin-Kyu & Lim, Soon. (2010). Physiological Activities of Extract from Edible Mushrooms. Journal of the Korean Society of Food Science and Nutrition. 39. 10.3746/jkfn.2010.39.8.1087.
https://www.researchgate.net/publication/264016424_Physiological_Activities_of_Extract_from_Edible_Mushrooms
30. Barros A. B, Bell V, Ferrão J, Calabrese V, Fernandes T. H. Mushroom Biomass: Some Clinical Implications of β-Glucans and Enzymes. Curr Res Nutr Food Sci 2016;4(Special Issue Confernce October 2016).
https://www.foodandnutritionjournal.org/vol04nospl-issue-conf-october-2016/mushroom-biomass-some-clinical-implications-of-%CE%B2-glucans-and-enzymes/
31. Kozarski M, Klaus A, Jakovljevic D, Todorovic N, Vunduk J, Petrović P, Niksic M, Vrvic MM, van Griensven L. Antioxidants of Edible Mushrooms. Molecules. 2015 Oct 27;20(10):19489-525. doi: 10.3390/molecules201019489. PMID: 26516828; PMCID: PMC6331815.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6331815/
ΕΡΙΚΙΟ ΤΟ ΑΓΚΑΘΩΤΟ και ΗΠΑΡ"
1. Hao L, Xie Y, Wu G, Cheng A, Liu X, Zheng R, Huo H, Zhang J. Protective Effect of Hericium erinaceus on Alcohol Induced Hepatotoxicity in Mice. Evid Based Complement Alternat Med. 2015;2015:418023. doi: 10.1155/2015/418023. Epub 2015 Apr 16. PMID: 25960751; PMCID: PMC4415743.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415743/
2. Cui, F., Gao, X., Zhang, J. et al. Protective Effects of Extracellular and Intracellular Polysaccharides on Hepatotoxicity by Hericium erinaceus SG-02. Curr Microbiol 73, 379–385 (2016). https://doi.org/10.1007/s00284-016-1073-1
https://link.springer.com/article/10.1007/s00284-016-1073-1
3. Lianchi Wu, Zhaoying Hu, Yujie Lv, Chaoyue Ge, Xinyu Luo, Shenao Zhan, Weichen Huang, Xinyu Shen, Dongyou Yu, Bing Liu, Hericium erinaceus polysaccharides ameliorate nonalcoholic fatty liver disease via gut microbiota and tryptophan metabolism regulation in an aged laying hen model, International ournal of Biological Macromolecules, Volume 273, Part 1, 2024, 132735, ISSN 0141-8130, https://doi.org/10.1016/j.ijbiomac.2024.132735.
https://www.sciencedirect.com/science/article/abs/pii/S0141813024035402
4. Hericium erinaceus Mushroom Extracts Protect Infected Mice against Salmonella Typhimurium-Induced Liver Damage and Mortality by Stimulation of Innate Immune Cells Sung Phil Kim, Eunpyo Moon, Seok Hyun Nam, and Mendel Friedman Journal of Agricultural and Food Chemistry 2012 60 (22), 5590-5596 DOI: 10.1021/jf300897w
https://pubs.acs.org/doi/10.1021/jf300897w
5. Zhang, C., Li, J., Hu, C. et al. Antihyperglycaemic and organic protective effects on pancreas, liver and kidney by polysaccharides from Hericium erinaceus SG-02 in streptozotocin-induced diabetic mice. Sci Rep 7, 10847 (2017). https://doi.org/10.1038/s41598-017-11457-w
https://www.nature.com/articles/s41598-017-11457-w
6. Kim SP, Nam SH, Friedman M. Hericium erinaceus (Lion's Mane) mushroom extracts inhibit metastasis of cancer cells to the lung in CT-26 colon cancer-tansplanted mice. J Agric Food Chem. 2013 May 22;61(20):4898-904. doi: 10.1021/jf400916c. Epub 2013 May 13. Erratum in: J Agric Food Chem. 2013 Jun 5;61(22):5411. Erratum in: J Agric Food Chem. 2014 Jan 15;62(2):528. PMID: 23668749.
https://www.ars.usda.gov/research/publications/publication/?seqNo115=295111
7. ΕΡΊΚΙΟ ΤΟ ΑΓΚΑΘΩΤΌ, Ιωάννης Κιούσης, Στέλεχος Διατροφής και Διαιτολογίας.
https://www.farmakeftikamanitaria.gr/erikio-to-agkathwto.html
8. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK547852/
https://www.ncbi.nlm.nih.gov/books/NBK547852/
9. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Categorization Of The Likelihood Of Drug Induced Liver Injury. [Updated 2019 May 4]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK548392/
https://www.ncbi.nlm.nih.gov/books/NBK548392/
10. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Lion’s Mane. [Updated 2024 Jan 5]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK599740/
https://www.ncbi.nlm.nih.gov/books/NBK599740/
Τί είναι η μυκοθεραπεία;
1. Molecules. 2019 Oct 24;24(21). Quercetin Synergistically Inhibit EBV-Associated Gastric Carcinoma with Ganoderma lucidum Extracts. Huh S, Lee S, Choi SJ, Wu Z, Cho JH, Kim L, Shin YS, Kang BW, Kim JG, Liu K, Cho H, Kang H.
http://europepmc.org/article/MED/31653035
2. Oncotarget. 2018 May 15;9(37):24837-24856. 2018 May 15. B-glucans from Grifola frondosa and Ganoderma lucidum in breast cancer: an example of complementary and integrative medicine. Rossi P, Difrancia R, Quagliariello V, Savino E, Tralongo P, Randazzo CL, Berretta M.
http://europepmc.org/article/MED/29872510
3. Int J Med Mushrooms. 2019;21(2):105-119. Cancer without Pharmacological Illusions and a Niche for Mycotherapy (Review). Zmitrovich IV, Belova NV, Balandaykin ME, Bondartseva MA, Wasser SP
https://pubmed.ncbi.nlm.nih.gov/30806218/
https://www.researchgate.net/publication/330527416_Cancer_without_pharmacological_illusions_and_a_niche_for_mycotherapy
4. Oncotarget, 9 (49), 29259-29274 2018 Jun 26 Medicinal Mushrooms as an Attractive New Source of Natural Compounds for Future Cancer Therapy Artem Blagodatski, Margarita Yatsunskaya, Valeriia Mikhailova, Vladlena Tiasto, Alexander Kagansky, Vladimir L Katanaev
https://pubmed.ncbi.nlm.nih.gov/30018750/
http://europepmc.org/article/MED/30018750
5. Curr Top Med Chem, 13 (21), 2791-806 2013 Mycotherapy of Cancer: An Update on Cytotoxic and Antitumor Activities of Mushrooms, Bioactive Principles and Molecular Mechanisms of Their Action Višnja Popović, Jelena Živković, Slobodan Davidović, Milena Stevanović, Dejan Stojković
https://pubmed.ncbi.nlm.nih.gov/24083788
6. Int J Med Mushrooms, 19 (4), 279-317 2017 Medicinal Mushrooms in Human Clinical Studies. Part I. Anticancer, Oncoimmunological, and Immunomodulatory Activities: A Review Solomon P Wasser
https://pubmed.ncbi.nlm.nih.gov/28605319
7. Biomed J, 37 (6), 345-56 Nov-Dec 2014 Medicinal Mushroom Science: Current Perspectives, Advances, Evidences, and Challenges Solomon P Wasser
https://pubmed.ncbi.nlm.nih.gov/25179726
8. Compendium of Mycotherapy Beate Berg Natural Medicine Centre, Witten, Germany Jan I. Lelley GAMU Ltd. Institute for Mushroom Research Hüttenallee 241, D-47800 Krefeld, Germany
https://www.begellhouse.com/pt/books/5a65edb04853cf0d.html
9. Mushrooms—Mycotherapy and Mycochemistry , Prof. Dr. Jasmina Glamočlija, Dr. Dejan Stojković, MDPI
https://www.mdpi.com/journal/jof/special_issues/mushrooms_mycotherapy
Διγοξίνη
1. Zhu JS, Halpern GM, Jones K. The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis: part I. J Altern Complement Med. 1998 Fall;4(3):289-303. doi: 10.1089/acm.1998.4.3-289. PMID: 9764768.
https://pubmed.ncbi.nlm.nih.gov/9764768/
2. American Herbal Products Association's Botanical Safety Handbook 2nd Edition by Zoë Gardner (Editor), Michael McGuffin (Editor
https://www.amazon.com/American-Products-Associations-Botanical-Handbook/dp/1466516941
https://books.google.gr/books?id=UdcZ2bttXaMC&pg=PA269&lpg=PA269&dq=cordyceps+digoxin&source=bl&ots=4u7H7VHfW8&sig=ACfU3U1R4hojAOeU5WYEWkbsqdn6dp578A&hl=el&sa=X&ved=2ahUKEwigxO7Z-qWGAxVWZ_EDHQQJAX04PBDoAXoECAkQAw#v=onepage&q=cordyceps%20digoxin&f=false
3. Rizal, Ardian & Sandra, Ferry & Rizki Fadlan, Muhamad & Sargowo, Djanggan. (2020). Ganoderma lucidum Polysaccharide Peptide Reduce Inflammation and Oxidative Stress in Patient with Atrial Fibrillation. The Indonesian Biomedical Journal. 12. 384-389. 10.18585/inabj.v12i4.1244.
https://www.researchgate.net/publication/347449665_Ganoderma_lucidum_Polysaccharide_Peptide_Reduce_Inflammation_and_Oxidative_Stress_in_Patient_with_Atrial_Fibrillation
Παιδιά
1. Lion's Mane: Everything You Need to Know By Megan Nunn, PharmD, June 29, 2023, Medically reviewed by Elizabeth Barnes, RDN
https://www.verywellhealth.com/lions-mane-benefits-and-nutrition-profile-7498004
2. Winder, Mateusz, Bulska-Będkowska, Weronika and Chudek, Jerzy. "The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology" Acta Pharmaceutica, vol.71, no.1, 2021, pp.1-16. https://doi.org/10.2478/acph-2021-0007
https://sciendo.com/article/10.2478/acph-2021-0007
Ερίκιο και Αντιαιμοπεταλιακή Αγωγή
1. Mori K, Kikuchi H, Obara Y, Iwashita M, Azumi Y, Kinugasa S, Inatomi S, Oshima Y, Nakahata N. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010 Dec 1;17(14):1082-5. doi: 10.1016/j.phymed.2010.05.004. Epub 2010 Jul 16. PMID: 20637576.
https://pubmed.ncbi.nlm.nih.gov/20637576/
2. GRAS Notification for the intended use of Lion's Mane mushroom p-glucans as a Food Ingredient, FDA, December 2, 2022
https://www.fda.gov/media/173805/download
3. Lion's Mane Mushroom, Medically reviewed by Drugs.com. Last updated on Nov 21, 2023.
https://www.drugs.com/npp/lion-s-mane-mushroom.htm
Ερίκιο παρενέργειες
1. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Lion’s Mane. [Updated 2024 Jan 5].
https://www.ncbi.nlm.nih.gov/books/NBK599740/
2. Lewis JE, Poles J, Shaw DP, Karhu E, Khan SA, Lyons AE, Sacco SB, McDaniel HR. The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. J Clin Transl Res. 2021 Aug 4;7(4):575-620. PMID: 34541370; PMCID: PMC8445631.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445631/
3. What evidence is there on the negative effects of lions mane mushroom supplements? Insight from top 3 papers
https://typeset.io/questions/what-evidence-is-there-on-the-negative-effects-of-lions-mane-57ff3q1lc6
4. Lion's Mane Mushroom, Drugs.com, Nov 21, 2023
https://www.drugs.com/npp/lion-s-mane-mushroom.html#side-effects
5. Chen SN, Chang CS, Yang MF, Chen S, Soni M, Mahadevan B. Subchronic toxicity and genotoxicity studies of Hericium erinaceus β-glucan extract preparation. Curr Res Toxicol. 2022 Mar 11;3:100068. doi: 10.1016/j.crtox.2022.100068. PMID: 35341120; PMCID: PMC8942846.
https://www.sciencedirect.com/science/article/pii/S2666027X22000056
6. Li IC, Chen YL, Lee LY, Chen WP, Tsai YT, Chen CC, Chen CS. Evaluation of the toxicological safety of erinacine A-enriched Hericium erinaceus in a 28-day oral feeding study in Sprague-Dawley rats. Food Chem Toxicol. 2014 Aug;70:61-7. doi: 10.1016/j.fct.2014.04.040. Epub 2014 May 6. PMID: 24810469.
https://pubmed.ncbi.nlm.nih.gov/24810469/
7. Park ID, Yoo HS, Lee YW, Son CG, Kwon M, Sung HJ, Cho CK. Toxicological study on MUNOPHIL, water extract of Panax ginseng and Hericium erinaceum in rats. J Acupunct Meridian Stud. 2008 Dec;1(2):121-7. doi: 10.1016/S2005-2901(09)60032-7. PMID: 20633464.
https://pubmed.ncbi.nlm.nih.gov/20633464/
8. Li IC, Lee LY, Tzeng TT, et al. Neurohealth Properties of <i>Hericium erinaceus</i> Mycelia Enriched with Erinacines. Behavioural Neurology. 2018;2018:5802634. DOI: 10.1155/2018/5802634. PMID: 29951133; PMCID: PMC5987239.
https://europepmc.org/article/MED/29951133
9. Li I-C, Chang H-H, Lin C-H, Chen W-P, Lu T-H, Lee L-Y, Chen Y-W, Chen Y-P, Chen C-C and Lin DP-C (2020) Prevention of Early Alzheimer’s Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study. Front. Aging Neurosci. 12:155. doi: 10.3389/fnagi.2020.00155
https://www.frontiersin.org/articles/10.3389/fnagi.2020.00155/full
10. Muhanna, M., Lund, I., Bromberg, M., Wicks, P., Benatar, M., Barnes, B., … Li, X. (2024). ALSUntangled #73: Lion’s Mane. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 25(3–4), 420–423. https://doi.org/10.1080/21678421.2023.2296557
https://www.tandfonline.com/doi/full/10.1080/21678421.2023.2296557
Β12
1.Tuli HS, Sandhu SS, Sharma AK. Pharmacological and therapeutic potential of Cordyceps with special reference to Cordycepin. 3 Biotech. 2014 Feb;4(1):1-12. doi: 10.1007/s13205-013-0121-9. Epub 2013 Feb 19. PMID: 28324458; PMCID: PMC3909570.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909570/
2. Savioli, Fellipe & Zogaib, Paulo & Franco, Eduardo & Salles, Fernando & Giorelli, Guilherme & Andreoli, Carlos. (2022). Effects of Cordyceps Sinensis Supplementation during 12 weeks in amateur marathoners: a randomized, double-blind placebo-controlled trial. Journal of Herbal Medicine. 34. 100570. 10.1016/j.hermed.2022.100570.
https://www.sciencedirect.com/science/article/abs/pii/S2210803322000392
3. Annals of Agri-Bio Research 27 (2) : 149-152, 2022 , Standardization of Parameters for the Mycelium Growth of Hericium erinaceus : An Edible Medicinal Mushroom, SAKSHI KHURANA, ARVIND, VIKASH KUMAR1, JAGDEEP SINGH2,# AND ANIL SINDHU
https://www.cabidigitallibrary.org/doi/pdf/10.5555/20220527076
4. Teng F, Bito T, Takenaka S, Yabuta Y, Watanabe F. Vitamin B12[c-lactone], a biologically inactive corrinoid compound, occurs in cultured and dried lion's mane mushroom (Hericium erinaceus) fruiting bodies. J Agric Food Chem. 2014 Feb 19;62(7):1726-32. doi: 10.1021/jf404463v. Epub 2014 Feb 7. PMID: 24506286.
https://pubmed.ncbi.nlm.nih.gov/24506286/
5. Lion's Mane Mushroom, Drugs.com,
https://www.drugs.com/npp/lion-s-mane-mushroom.html
