Κεφάλαιο 4: Σε ποιες περιπτώσεις χρησιμοποιούνται
Καρκίνος
1. Ambhore JP, Adhao VS, Rafique SS, Telgote A, Dhoran RS, Shende BA. A concise review: edible mushroom and their medicinal significance. Explor Foods Foodomics. 2024;2:183–94. https://doi.org/10.37349/eff.2024.00033
https://www.explorationpub.com/Journals/eff/Article/101033
2. Anuradha Mishra, S Shankar, Edible mushrooms for improved human health, food security and environmental sustainability: A critical review, Science of The Total Environment, Volume 995, 2025, 180093, ISSN 0048-9697, https://doi.org/10.1016/j.scitotenv.2025.180093.
https://www.sciencedirect.com/science/article/abs/pii/S0048969725017334
3. Łysakowska, P.; Sobota, A.; Wirkijowska, A. Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production—A Review. Molecules 2023, 28, 5393. https://doi.org/10.3390/molecules28145393
https://www.mdpi.com/1420-3049/28/14/5393
4. Feeney, Mary Jo MS, RDN, FADA, FAND; Miller, Amy Myrdal MS, RDN; Roupas, Peter PhD. Mushrooms—Biologically Distinct and Nutritionally Unique: Exploring a “Third Food Kingdom”. Nutrition Today 49(6):p 301-307, November/December 2014. | DOI: 10.1097/NT.0000000000000063
https://journals.lww.com/nutritiontodayonline/fulltext/2014/11000/mushrooms_biologically_distinct_and_nutritionally.10.aspx
5. Bell, Victoria & Silva, C. & Guina, José Augusto & Th, Fernandes. (2022). Mushrooms as future generation healthy foods. Frontiers in Nutrition. 9. 1050099. 10.3389/fnut.2022.1050099.
https://www.researchgate.net/publication/366031437_Mushrooms_as_future_generation_healthy_foods
6. A Review: Health Benefits and Quality Value of Mushroom Anshu Mala, Shwet Kamal, BL Attri, International Journal for Multidisciplinary Research (IJFMR) E-ISSN: 2582-2160
https://www.ijfmr.com/papers/2023/4/4841.pdf
7. Khan,Najmu Saqib and Kumar,Pranav and Taki,Rachel and Giri,Ramesh and Geetika, 20220422079, English, Journal article, India, 0970-0420, 40, (2A), Kolkata, Environment and Ecology, (540–553), MKK Publication, An overview and study on edible mushrooms: human health benefits and promoting quality of life., (2022)
https://www.cabidigitallibrary.org/doi/full/10.5555/20220422079
8. Valverde ME, Hernández-Pérez T, Paredes-López O. Edible mushrooms: improving human health and promoting quality life. Int J Microbiol. 2015;2015:376387. doi: 10.1155/2015/376387. Epub 2015 Jan 20. PMID: 25685150; PMCID: PMC4320875.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4320875/
9. PDQ® Integrative, Alternative, and Complementary Therapies Editorial Board. PDQ Medicinal Mushrooms. Bethesda, MD: National Cancer Institute. Updated July 11, 2024. Available at: https://www.cancer.gov/about-cancer/treatment/cam/patient/mushrooms-pdq. Accessed <8/1/2025>. [PMID: 28267306]
10. Zmitrovich IV, Bondartseva MA, Arefyev SP, Perelygin VV. Professor Solomon P. Wasser and Medicinal Mushroom Science, with Special Attention to the Problems of Mycotherapy in Oncology. Int J Med Mushrooms. 2022;24(1):13-26. doi: 10.1615/IntJMedMushrooms.2021041831. PMID: 35442592.
https://pubmed.ncbi.nlm.nih.gov/35442592/
11. International Journal of Medicinal Mushrooms Editor-in-Chief: Solomon P. Wasser (open in a new tab) Published 12 issues per year ISSN Print: 1521-9437 ISSN Online: 1940-4344
https://www.dl.begellhouse.com/journals/708ae68d64b17c52,35ee20ab487c6e00,26e32c6444922c12.html
12. Int J Med Mushrooms, 19 (4), 279-317 2017 Medicinal Mushrooms in Human Clinical Studies. Part I. Anticancer, Oncoimmunological, and Immunomodulatory Activities: A Review Solomon P Wasser
https://pubmed.ncbi.nlm.nih.gov/28605319
13. News articles 7 May 2024 Main cause of death for people under 65 years: cancer, Eurostat
https://ec.europa.eu/eurostat/web/products-eurostat-news/w/ddn-20240507-1
14. August 23, 2024 Cancer has replaced cardiovascular diseases as the leading cause of death in several wealthy countries, Our World in Data
https://ourworldindata.org/data-insights/cancer-has-replaced-cardiovascular-diseases-as-the-leading-cause-of-death-in-several-wealthy-countries
15. Chemotherapy Side Effects, May 15, 2025 American Cancer Society,
https://www.cancer.org/cancer/managing-cancer/treatment-types/chemotherapy/chemotherapy-side-effects.html
16. Mitchell, E., Pham, M.H., Clay, A. et al. The long-term effects of chemotherapy on normal blood cells. Nat Genet 57, 1684–1694 (2025). https://doi.org/10.1038/s41588-025-02234-x
https://www.nature.com/articles/s41588-025-02234-x
17. Bentharavithana J, Islam T, Xu B. Medicinal Mushrooms in Colon Cancer Therapy: Mechanisms of Action of Bioactive Compounds and Therapeutic Potential. Int J Mol Sci. 2025 May 31;26(11):5304. doi: 10.3390/ijms26115304. PMID: 40508113; PMCID: PMC12154085.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12154085/
18. Panda, S.K.; Sahoo, G.; Swain, S.S.; Luyten, W. Anticancer Activities of Mushrooms: A Neglected Source for Drug Discovery. Pharmaceuticals 2022, 15, 176. https://doi.org/10.3390/ph15020176
https://www.mdpi.com/1424-8247/15/2/176
19. Sudeshna Nandi, Rimpa Sikder, Sylvie Rapior, Stéphanie Arnould, Jesus Simal-Gandara, Krishnendu Acharya, A review for cancer treatment with mushroom metabolites through targeting mitochondrial signaling pathway: In vitro and in vivo evaluations, clinical studies and future prospects for mycomedicine, Fitoterapia, Volume 172, 2024, 105681, ISSN 0367-326X, https://doi.org/10.1016/j.fitote.2023.105681.
https://www.sciencedirect.com/science/article/pii/S0367326X23002563
20. Smith, J.E. & Rowan, Neil. (2002). Medicinal Mushrooms: Their Therapeutic Properties and Current Medical Usage with Special Emphasis on Cancer Treatments. University of Strathclyde, Cancer Research UK. iv and 253.
https://www.academia.edu/305933/Medicinal_Mushrooms_Their_therapeutic_properties_and_current_medical_usage_with_special_emphasis_on_cancer_treatments
21. Ahn WS, Kim DJ, Chae GT, Lee JM, Bae SM, Sin JI, Kim YW, Namkoong SE, Lee IP. Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Int J Gynecol Cancer. 2004 Jul-Aug;14(4):589-94. doi: 10.1111/j.1048-891X.2004.14403.x. PMID: 15304151.
https://www.international-journal-of-gynecological-cancer.com/article/S1048-891X(24)15045-1/pdf
22. Kodama N, Komuta K, Nanba H. Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients. J Med Food. 2003 Winter;6(4):371-7. doi: 10.1089/109662003772519949. PMID: 14977447.
https://pubmed.ncbi.nlm.nih.gov/14977447/
23. Kodama N, Komuta K, Nanba H. Can maitake MD-fraction aid cancer patients? Altern Med Rev. 2002 Jun;7(3):236-9. PMID: 12126464.
https://pubmed.ncbi.nlm.nih.gov/12126464/
24. TianX, Lun Z, Ito J.Clinical observation on treatment of acute non lymphocytic leukemia with Agaricus blazei. Lanzhou Med Coll 1994;20:169–171.
https://www.springboard4health.com/notebook/health_agaricus_6.html
25. Wesa KM, Cunningham-Rundles S, Klimek VM, Vertosick E, Coleton MI, Yeung KS, Lin H, Nimer S, Cassileth BR. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother. 2015 Feb;64(2):237-47. doi: 10.1007/s00262-014-1628-6. Epub 2014 Oct 29. PMID: 25351719; PMCID: PMC4317517.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4317517/
26. Jakopovic B, Horvatić A, Baranasic J, Car I, Oršolić N, Jakopovich I, Sedić M and Kraljević Pavelić S (2024) Proteomic study of medicinal mushroom extracts reveals antitumor mechanisms in an advanced colon cancer animal model via ribosomal biogenesis, translation, and metabolic pathways. Front. Pharmacol. 15:1475102. doi: 10.3389/fphar.2024.1475102
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1475102/full
27. De Silva, D.D., Rapior, S., Fons, F. et al. Medicinal mushrooms in supportive cancer therapies: an approach to anti-cancer effects and putative mechanisms of action. Fungal Diversity 55, 1–35 (2012). https://doi.org/10.1007/s13225-012-0151-3
https://link.springer.com/article/10.1007/s13225-012-0151-3
28. Park HJ. Current Uses of Mushrooms in Cancer Treatment and Their Anticancer Mechanisms. Int J Mol Sci. 2022 Sep 10;23(18):10502. doi: 10.3390/ijms231810502. PMID: 36142412; PMCID: PMC9504980.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9504980/
29. National Library of Medicine, International journal of medicinal mushrooms, 1999
https://pmc.ncbi.nlm.nih.gov/articles/PMC9504980/
30. Suprasert P, Apichartpiyakul C, Sakonwasun C, Nitisuwanraksa P, Phuackchantuck R (2015) A Randomized Double Blinded Study of Ganoderma Lucidum (Lingzhi) in Salvage Setting of Recurrent Gynecologic Cancer. Int J Cancer Clin Res 2:021. 10.23937/2378-3419/2/3/1021
https://clinmedjournals.org/articles/ijccr/international-journal-of-cancer-and-clinical-research-ijccr-2-021.php?jid=ijccr
31. Suprasert P, Apichartpiyakul C, Sakonwasun C, Nitisuwanraksa P, Phuackchantuck R. Clinical characteristics of gynecologic cancer patients who respond to salvage treatment with Lingzhi. Asian Pac J Cancer Prev. 2014;15(10):4193-6. doi: 10.7314/apjcp.2014.15.10.4193. PMID: 24935369.
https://journal.waocp.org/article_29222_26e3ad041a7015d9bdf15628e47929f3.pdf
32. Lin Z, Sun L. Antitumor Effect of Ganoderma (Lingzhi) Mediated by Immunological Mechanism and Its Clinical Application. Adv Exp Med Biol. 2019;1182:39-77. doi: 10.1007/978-981-32-9421-9_2. PMID: 31777014.
https://pubmed.ncbi.nlm.nih.gov/31777014/
33. Li X, He Y, Zeng P, Liu Y, Zhang M, Hao C, Wang H, Lv Z, Zhang L. Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in China. J Cell Mol Med. 2019 Jan;23(1):4-20. doi: 10.1111/jcmm.13564. Epub 2018 Nov 15. PMID: 30444050; PMCID: PMC6307810.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307810/
34. Chen MH, May BH, Zhou IW, Zhang AL, Xue CC. Integrative Medicine for Relief of Nausea and Vomiting in the Treatment of Colorectal Cancer Using Oxaliplatin-Based Chemotherapy: A Systematic Review and Meta-Analysis. Phytother Res. 2016 May;30(5):741-53. doi: 10.1002/ptr.5586. Epub 2016 Feb 23. PMID: 26912094.
https://pubmed.ncbi.nlm.nih.gov/26912094/
35. Chen M, May BH, Zhou IW, Sze DM, Xue CC, Zhang AL. Oxaliplatin-based chemotherapy combined with traditional medicines for neutropenia in colorectal cancer: A meta-analysis of the contributions of specific plants. Crit Rev Oncol Hematol. 2016 Sep;105:18-34. doi: 10.1016/j.critrevonc.2016.07.002. Epub 2016 Jul 7. PMID: 27497028.
https://pubmed.ncbi.nlm.nih.gov/27497028/
36. Chen M, May BH, Zhou IW, Xue CC, Zhang AL. FOLFOX 4 combined with herbal medicine for advanced colorectal cancer: a systematic review. Phytother Res. 2014 Jul;28(7):976-91. doi: 10.1002/ptr.5092. Epub 2013 Dec 17. PMID: 24343974.
https://pubmed.ncbi.nlm.nih.gov/24343974/
37. Mendes LC. Effective fuling (Poria Cocos) for the treatment of obesity? Int J Complement Alt Med. 2018;11(6):380-385. DOI: 10.15406/ijcam.2018.11.00430
https://medcraveonline.com/IJCAM/effective-fuling-poria-cocos-for-the-treatment-of-obesity.html
38. Goday A, Barneto I, García-Almeida JM, Blasco A, Lecube A, Grávalos C, Martínez de Icaya P, de las Peñas R, Monereo S, Vázquez L, Palacio JE, Pérez-Segura P. Obesity as a risk factor in cancer: A national consensus of the Spanish Society for the Study of Obesity and the Spanish Society of Medical Oncology. Clin Transl Oncol. 2015 Oct;17(10):763-71. doi: 10.1007/s12094-015-1306-y. Epub 2015 Jun 3. PMID: 26036853.
https://www.seom.org/seomcms/images/stories/recursos/ClinicalTranslationOncology2015.pdf
39. Vucenik I, Stains JP. Obesity and cancer risk: evidence, mechanisms, and recommendations. Ann N Y Acad Sci. 2012 Oct;1271(1):37-43. doi: 10.1111/j.1749-6632.2012.06750.x. PMID: 23050962; PMCID: PMC3476838.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3476838/
40. Li, Qiuhuaa,b; Wang, Yingc; Ren, Lud,∗; Liu, Zhaozhee,∗. Noncausal relationship between body weight and breast cancer based on bidirectional Mendelian randomization evidence. Oncology and Translational Medicine 10(5):p 245-251, October 2024. | DOI: 10.1097/ot9.0000000000000058
https://journals.lww.com/otm/fulltext/2024/10000/noncausal_relationship_between_body_weight_and.6.aspx#:~:text=Being%20overweight%20or%20obese%20increases%20the%20risk,types%20of%20cancer,%20including%20postmenopausal%20breast%20cancer.
41. Pati S, Irfan W, Jameel A, Ahmed S, Shahid RK. Obesity and Cancer: A Current Overview of Epidemiology, Pathogenesis, Outcomes, and Management. Cancers (Basel). 2023 Jan 12;15(2):485. doi: 10.3390/cancers15020485. PMID: 36672434; PMCID: PMC9857053.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9857053/
42. Zhou DH, Lin LZ. [Effect of Jinshuibao capsule on the immunological function of 36 patients with advanced cancer]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995 Aug;15(8):476-8. Chinese. PMID: 8580695.
https://pubmed.ncbi.nlm.nih.gov/8580695/
43. The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II. Zhu JS1, Halpern GM, Jones K., J Altern Complement Med. 1998 Winter;4(4):429-57.
https://pubmed.ncbi.nlm.nih.gov/9884180/
44. University of Oxford, Anti-cancer drug derived from fungus shows promise in clinical trials, 8 Oct 2021,
https://www.ox.ac.uk/news/2021-10-08-anti-cancer-drug-derived-fungus-shows-promise-clinical-trials
45. Cochrane Database Syst Rev, 2012, Ganoderma Lucidum (Reishi Mushroom) for Cancer Treatment, Xingzhong Jin, Julieta Ruiz Beguerie, Daniel Man-Yeun Sze, Godfrey C F Chan
https://pubmed.ncbi.nlm.nih.gov/22696372/
46. Cochrane Database Syst Rev, 4 (4), CD007731 2016 Apr 5 Ganoderma Lucidum (Reishi Mushroom) for Cancer Treatment Xingzhong Jin 1 , Julieta Ruiz Beguerie, Daniel Man-Yeun Sze, Godfrey C F Chan
https://europepmc.org/article/MED/27045603
47. Cao Y, Xu X, Liu S, Huang L, Gu J. Ganoderma: A Cancer Immunotherapy Review. Front Pharmacol. 2018 Oct 25;9:1217. doi: 10.3389/fphar.2018.01217. PMID: 30410443; PMCID: PMC6209820.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209820
48. Review J Ethnopharmacol. 2020 Jun 3;260:113047. Online ahead of print. Ganoderma Lucidum: A Rational Pharmacological Approach to Surmount Cancer Md Faruque Ahmad
https://pubmed.ncbi.nlm.nih.gov/32504783/
49. Johnson BM, Doonan BP, Radwan FF, Haque A. Ganoderic Acid DM: An Alternative Agent for the Treatment of Advanced Prostate Cancer. Open Prost Cancer J. 2010 Jan 1;3:78-85. doi: 10.2174/1876822901003010078. PMID: 24790681; PMCID: PMC4002166.
https://pubmed.ncbi.nlm.nih.gov/24790681/
50. Zhao X, Zhou D, Liu Y, Li C, Zhao X, Li Y, Li W. Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway. Mol Med Rep. 2018 Jan;17(1):147-157. doi: 10.3892/mmr.2017.7904. Epub 2017 Oct 26. PMID: 29115463; PMCID: PMC5780085.
https://pubmed.ncbi.nlm.nih.gov/29115463/
51. Liu J, Shiono J, Shimizu K, Kukita A, Kukita T, Kondo R. Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2154-7. doi: 10.1016/j.bmcl.2009.02.119. Epub 2009 Mar 4. PMID: 19289282.
https://pubmed.ncbi.nlm.nih.gov/19289282/
52. Liang C, Tian D, Liu Y, Li H, Zhu J, Li M, Xin M, Xia J. Review of the molecular mechanisms of Ganoderma lucidum triterpenoids: Ganoderic acids A, C2, D, F, DM, X and Y. Eur J Med Chem. 2019 Jul 15;174:130-141. doi: 10.1016/j.ejmech.2019.04.039. Epub 2019 Apr 20. PMID: 31035236.
https://pubmed.ncbi.nlm.nih.gov/31035236/
53. Cizmarikova M. The Efficacy and Toxicity of Using the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), and Its Products in Chemotherapy (Review). Int J Med Mushrooms. 2017;19(10):861-877. doi: 10.1615/IntJMedMushrooms.2017024537. PMID: 29256841.
https://pubmed.ncbi.nlm.nih.gov/29256841/
54. ARBS Annual Review of Biomedical Sciences Antitumor Properties of Ganoderma lucidum Polysaccharides and Terpenoids, in Annual Review of Biomedical Sciences · January 2011, Marcela Camargo, Ramon Kaneno
www.researchgate.net/publication/232722630_ARBS_Annual_Review_of_Biomedical_Sciences_Antitumor_Properties_of_Ganoderma_lucidum_Polysaccharides_and_Terpenoids
55. Medicinal Mushrooms (PDQ®): Health Professional Version PDQ Integrative, Alternative, and Complementary Therapies Editorial Board In: PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002–. 2019 Oct 25.
https://pubmed.ncbi.nlm.nih.gov/27929633/
56. Mycotherapy of cancer: an update on cytotoxic and antitumor activities of mushrooms, bioactive principles and molecular mechanisms of their action. Popović V, Živković J, Davidović S, Stevanović M, Stojković D. Curr Top Med Chem. 2013.
https://pubmed.ncbi.nlm.nih.gov/24083788
57. Cancer without Pharmacological Illusions and a Niche for Mycotherapy (Review). Zmitrovich IV, Belova NV, Balandaykin ME, Bondartseva MA, Wasser SP5. Int J Med Mushrooms. 2019;21(2):105-119.
https://pubmed.ncbi.nlm.nih.gov/30806218/
58. Ganoderma lucidum: a potent pharmacological macrofungus. Sanodiya BS, Thakur GS, Baghel RK, Prasad GB, Bisen PS. Curr Pharm Biotechnol. 2009 Dec;10(8):717-42.
https://pubmed.ncbi.nlm.nih.gov/19939212
59. Integr Cancer Ther. 2015 May;14(3):249-57. doi: 10.1177/1534735414568721. Epub 2015 Jan 27. Ganoderma lucidum for cancer treatment: we are close but still not there. Cheng S1, Sliva D2.
https://pubmed.ncbi.nlm.nih.gov/25626896/
60. Exp Ther Med. 2017 Oct;14(4):3273-3278. doi: 10.3892/etm.2017.4883. Epub 2017 Aug 3. Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors. Zheng DS1, Chen LS2.
http://europepmc.org/article/MED/28912878
61. St. Jude, Biologically Active Ganoderma Lucidum Compounds and Synthesis of Derivatives and Probes
https://www.stjude.org/research/shared-resources/technology-licensing/technologies/biologically-active-ganoderma-lucidum-compounds-and-synthesis-of-derivatives-and-probes-sj-19-0035.html
62. https://hospitals.webometrics.info/en/world
63. Anticancer Agents Med Chem, 18 (5), 667-674 2018 Ganoderma Lucidum Polysaccharides as An Anti-cancer Agent Didem Sohretoglu, Shile Huang
https://pubmed.ncbi.nlm.nih.gov/29141563/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624854/
64. Do Mushroom Supplements Boost Immunity Against Cancer? By Susan Wagner Tuesday, October 22, 2024, Memorial Sloan Kettering Cancer Center
https://www.mskcc.org/news/do-mushroom-supplements-boost-immunity-against-cancer
65. Memorial Sloan Kettering Cancer Center, Tuesday, February 14, 2023, Shiitake Mushroom
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/shiitake-mushroom
66. Memorial Sloan Kettering Cancer Center, Tuesday, May 31, 2022, Coriolus versicolor
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/coriolus-versicolor
67. Memorial Sloan Kettering Cancer Center, Friday, May 13, 2022, Maitake
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/maitake
68. Memorial Sloan Kettering Cancer Center, Friday, February 4, 2022, Phellinus linteus
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/phellinus-linteus
69. Memorial Sloan Kettering Cancer Center, Thursday, February 10, 2022, Agaricus
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/agaricus
70. Memorial Sloan Kettering Cancer Center, Thursday, February 9, 2023, Reishi Mushroom
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/reishi-mushroom
71. Memorial Sloan Kettering Cancer Center, Monday, February 20, 2023, Chaga Mushroom
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/chaga-mushroom
72. Memorial Sloan Kettering Cancer Center, Wednesday, June 5, 2024, Lion's Mane Mushroom
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/lions-mane-mushroom
73. Memorial Sloan Kettering Cancer Center, Friday, July 8, 2022, Oyster mushroom
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/oyster-mushroom
74. Memorial Sloan Kettering Cancer Center, Thursday, February 10, 2022, Cordyceps
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/cordyceps
75. Memorial Sloan Kettering Cancer Center Ranked the Best Cancer Center in the Northeast and First in the Nation for Urology Care by U.S. News & World Report, Tuesday, August 1, 2023
https://www.mskcc.org/news-releases/mskcc-ranked-best-cancer-center-in-northeast-and-first-in-nation-for-urology-care-by-u-s-news-world-report
76. Immunol Invest, 2003, Effects of Ganopoly (A Ganoderma Lucidum Polysaccharide Extract) on the Immune Functions in Advanced-Stage Cancer Patients, Yihuai Gao, Shufeng Zhou, Wenqi Jiang, Min Huang, Xihu Dai
https://pubmed.ncbi.nlm.nih.gov/12916709/
77. Asian Pac J Cancer Prev, 15 (10), 4193-6 2014 Clinical Characteristics of Gynecologic Cancer Patients Who Respond to Salvage Treatment With Lingzhi Prapaporn Suprasert, Chatchawann Apichartpiyakul, Choompone Sakonwasun, Pimonphan Nitisuwanraksa, Rochana Phuackchantuck
https://pubmed.ncbi.nlm.nih.gov/24935369
78. “And What Other Medications Are You Taking?” John D. Gordan Wen-Yee Chay R. Kate Kelley , Andrew H. Ko Su-Pin Choo Alan P. Venook Show More, Journal of Clinical Oncology
https://ascopubs.org/doi/full/10.1200/jco.2010.32.8054?cited-by=yes&legid=jco%3B29%2F11%2Fe288
79. Hiroshima J Med Sci. 2010. A water-soluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomas. Oka S, Tanaka S, Yoshida S, Hiyama T, Ueno Y, Ito M, Kitadai Y, Yoshihara M, Chayama K.
https://pubmed.ncbi.nlm.nih.gov/20518254/
80. Journal of Clinical Oncology, Volume 26, Issue 15, Randomized, double-blind and placebo-controlled study of the immunomodulatory effects of Lingzhi in children with cancers M. K. Shing, T. F. Leung, Y. L. Chu, C. Y. Li, K. W. Chik, P. C. LeungV. Lee, P. M. Yuen, C. K. Li
https://ascopubs.org/doi/abs/10.1200/jco.2008.26.15_suppl.14021
81. Int Immunopharmacol, 6 (3), 499-508 Mar 2006 Monitoring of Immune Responses to a Herbal Immuno-Modulator in Patients With Advanced Colorectal Cancer Xiao Chen, Ze-Ping Hu, Xiao-Xia Yang, Min Huang, Yihuai Gao, Wenbo Tang, Sui Yung Chan, Xihu Dai, Jinxian Ye, Paul Chi-Liu Ho, Wei Duan, Hong-Yuan Yang, Yi-Zhun Zhu, Shu-Feng Zhou
https://pubmed.ncbi.nlm.nih.gov/16428086/
82. Λέμφωμα μη Hodgkin (NHL), Lymphoma Australia
https://www.lymphoma.org.au/el/types-of-lymphoma/non-hodgkin-lymphoma/
83. Cheuk W, Chan JK, Nuovo G, Chan MK, Fok M. Regression of gastric large B-Cell lymphoma accompanied by a florid lymphoma-like T-cell reaction: immunomodulatory effect of Ganoderma lucidum (Lingzhi)? Int J Surg Pathol. 2007 Apr;15(2):180-6. doi: 10.1177/1066896906295890. PMID: 17478779.
https://pubmed.ncbi.nlm.nih.gov/17478779/
84. Hossain, Masud & Bhowmick, Sujan & Sarkar, Md Marzan & Basunia, Mafroz & Choudhury, Bazlul & Hossain, Shahdat. (2018). Effects of Ganoderma Lucidum on Palliative Care In Oral Squamous Cell Carcinoma (OSCC) Patients: An Evidence of Excellent Postoperative Support for Cancer Patients. IOSR Journal of Dental and Medical Sciences. 17. 10.9790/0853-1701107687.
https://www.researchgate.net/publication/322790454_Effects_of_Ganoderma_Lucidum_on_Palliative_Care_In_Oral_Squamous_Cell_Carcinoma_OSCC_Patients_An_Evidence_of_Excellent_Postoperative_Support_for_Cancer_Patients
85. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614. doi: 10.1155/2012/809614. Epub 2011 Dec 10. PMID: 22203880; PMCID: PMC3236089.
https://pubmed.ncbi.nlm.nih.gov/22203880/
86. Small Cell Lung Cancer vs. Non-small Cell Lung Cancer: What’s the Difference? National Foundation for Cancer Research, November 4, 2020
https://www.nfcr.org/blog/small-cell-lung-cancer-vs-non-small-cell-lung-cancer-whats-the-difference/
87. Zappa C, Mousa SA. Non-small cell lung cancer: current treatment and future advances. Transl Lung Cancer Res. 2016 Jun;5(3):288-300. doi: 10.21037/tlcr.2016.06.07. PMID: 27413711; PMCID: PMC4931124.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931124/
88. Treatment for lung cancer, national institutes for health and care excellence
https://www.nice.org.uk/about/what-we-do/into-practice/measuring-the-use-of-nice-guidance/impact-of-our-guidance/niceimpact-lung-cancer/ch4-treatment-for-lung-cancer
89. Niu FY, Zhou Q, Yang JJ, Zhong WZ, Chen ZH, Deng W, He YY, Chen HJ, Zeng Z, Ke EE, Zhao N, Zhang N, Sun HW, Zhang QY, Xie Z, Zhang XC, Wu YL. Distribution and prognosis of uncommon metastases from non-small cell lung cancer. BMC Cancer. 2016 Feb 24;16:149. doi: 10.1186/s12885-016-2169-5. PMID: 26911831; PMCID: PMC4766662.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766662/
90. Hong, Y., Park, S. & Lee, M.K. The prognosis of non-small cell lung cancer patients according to endobronchial metastatic lesion. Sci Rep 12, 13588 (2022). https://doi.org/10.1038/s41598-022-17918-1
https://www.nature.com/articles/s41598-022-17918-1
91. Lung Cancer Survival Rates, American Cancer Society, January 29, 2024
https://www.cancer.org/cancer/types/lung-cancer/detection-diagnosis-staging/survival-rates.html
92. Clough W, Al Jaberi M, Dalia S. Non-small cell lung cancer with MET exon 14 skip mutation: case report. Ann Transl Med 2022;10(23):1287. doi: 10.21037/atm-2022-53
https://atm.amegroups.org/article/view/104773/html
93. National Cancer Institute at the National Institutes of Health, Non-Small Cell Lung Cancer Treatment (PDQ®)–Health Professional Version, June 21, 2024
https://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq
94. What is metastatic lung cancer? Cancer Research UK, 20 Mar 2023
https://www.cancerresearchuk.org/about-cancer/lung-cancer/metastatic/what-is
95. Gao Y., Dai X., Chen G., Ye J., Zhou S. A randomized, placebo-controlled, multicenter study of Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) polysaccharides (Ganopoly) in patients with advanced lung cancer. Int. J. Med. Mushrooms. 2003;5:14. doi: 10.1615/InterJMedicMush.v5.i4.40
https://europepmc.org/article/MED/35215289
96. Cell Physiol Biochem. 2014. Protection against lung cancer patient plasma-induced lymphocyte suppression by Ganoderma lucidum polysaccharides. Sun LX1, Li WD, Lin ZB, Duan XS, Li XF, Yang N, Lan TF, Li M, Sun Y, Yu M, Lu J.
https://pubmed.ncbi.nlm.nih.gov/24525691/
97. Overview - Lung cancer, NHS, 01 November 2022
https://www.nhs.uk/conditions/lung-cancer/
98. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024 May-Jun;74(3):229-263. doi: 10.3322/caac.21834. Epub 2024 Apr 4. PMID: 38572751.
https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21834
99. Lung cancer, Mayo Clinic Staff
https://www.mayoclinic.org/diseases-conditions/lung-cancer/symptoms-causes/syc-20374620
100. 16 Unexpected Lung Cancer Symptoms You Should Know About, Rocky Mountain Cancer Centers
https://www.rockymountaincancercenters.com/blog/16-unexpected-signs-and-symptoms-of-lung-cancer
101. Types of lung cancer, 30 Dec 2022, Cancer Research UK
https://www.cancerresearchuk.org/about-cancer/lung-cancer/stages-types-grades/types
102. Key Statistics for Lung Cancer, January 29, 2024, American Cancer Society
https://www.cancer.org/cancer/types/lung-cancer/about/key-statistics.html
103. Xie A, Croce B, Tian DH. Smoking and lung cancer. Ann Cardiothorac Surg. 2014 Mar;3(2):221. doi: 10.3978/j.issn.2225-319X.2014.03.09. PMID: 24790854; PMCID: PMC3988304.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988304/
104. Lung Cancer Risk Factors, American Cancer Society, January 29, 2024
https://www.cancer.org/cancer/types/lung-cancer/causes-risks-prevention/risk-factors.html
105. Lung Cancer Treatment, The Johns Hopkins University
https://www.hopkinsmedicine.org/health/conditions-and-diseases/lung-cancer/lung-cancer-treatment
106. Clinical Trials, National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894, Shiitake
https://clinicaltrials.gov/search?cond=Shiitake&viewType=Card
107. Clinical Trials, National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894, coriolus versicolor
https://clinicaltrials.gov/search?cond=Coriolus%20versicolor%20&viewType=Card
108. Clinical Trials, National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894, Maitake
https://clinicaltrials.gov/search?cond=Maitake%20&viewType=Card
109. Clinical Trials, National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894, Agaricus
https://clinicaltrials.gov/search?cond=Agaricus%20&viewType=Card
110. Clinical Trials, National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894, Cordyceps
https://clinicaltrials.gov/search?cond=Cordyceps&viewType=Card
111. Clinical Trials, National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894, ganoderma
https://clinicaltrials.gov/search?cond=ganoderma&viewType=Card
112. Pasalioglu KB, Kaya H. Catheter indwell time and phlebitis development during peripheral intravenous catheter administration. Pak J Med Sci. 2014 Jul;30(4):725-30. PMID: 25097505; PMCID: PMC4121686.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121686/
113. Biswal SG, Mehta RD. Cutaneous adverse reactions of chemotherapy in cancer patients: A clinicoepidemiological study. Indian J Dermatol 2018;63:41-6
https://www.e-ijd.org/article.asp?issn=0019-5154;year=2018;volume=63;issue=1;spage=41;epage=46;aulast=Biswal
114. Tzolos E, Salawu A. Improving the frequency of visual infusion phlebitis (VIP) scoring on an oncology ward. BMJ Qual Improv Rep. 2014 Sep 12;3(1):u205455.w2364. doi: 10.1136/bmjquality.u205455.w2364. PMID: 26734282; PMCID: PMC4645857.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645857/
115. Application Status of Phytotherapy for Prevention and Treatment of Chemotherapy Induced Phlebitis / 中国中医药信息杂志 Juan SHEN; Jing ZHANG; Weiwei YIN; Ligao WU. Chinese Journal of Information on Traditional Chinese Medicine ; (12): 134-136, 2016. Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wpr-489999
https://pesquisa.bvsalud.org/portal/resource/pt/wpr-489999
116. de Souza RGM, Schincaglia RM, Pimentel GD, Mota JF. Nuts and Human Health Outcomes: A Systematic Review. Nutrients. 2017 Dec 2;9(12):1311. doi: 10.3390/nu9121311. PMID: 29207471; PMCID: PMC5748761.
https://pubmed.ncbi.nlm.nih.gov/29207471
117. Falasca M, Casari I. Cancer chemoprevention by nuts: evidence and promises. Front Biosci (Schol Ed). 2012 Jan 1;4(1):109-20. doi: 10.2741/254. PMID: 22202046.
https://pubmed.ncbi.nlm.nih.gov/22202046/
118. Ros E, Singh A, O'Keefe JH. Nuts: Natural Pleiotropic Nutraceuticals. Nutrients. 2021 Sep 19;13(9):3269. doi: 10.3390/nu13093269. PMID: 34579146; PMCID: PMC8468443.
https://pubmed.ncbi.nlm.nih.gov/34579146
119. Falasca M, Casari I, Maffucci T. Cancer chemoprevention with nuts. J Natl Cancer Inst. 2014 Sep 10;106(9):dju238. doi: 10.1093/jnci/dju238. PMID: 25210199.
https://pubmed.ncbi.nlm.nih.gov/25210199/
120. Zhang D, Dai C, Zhou L, Li Y, Liu K, Deng YJ, Li N, Zheng Y, Hao Q, Yang S, Song D, Wu Y, Zhai Z, Cao S, Dai Z. Meta-analysis of the association between nut consumption and the risks of cancer incidence and cancer-specific mortality. Aging (Albany NY). 2020 Jun 2;12(11):10772-10794. doi: 10.18632/aging.103292. Epub 2020 Jun 2. PMID: 32487780; PMCID: PMC7346045.
https://pubmed.ncbi.nlm.nih.gov/32487780/
121. Naghshi S, Sadeghian M, Nasiri M, Mobarak S, Asadi M, Sadeghi O. Association of Total Nut, Tree Nut, Peanut, and Peanut Butter Consumption with Cancer Incidence and Mortality: A Comprehensive Systematic Review and Dose-Response Meta-Analysis of Observational Studies. Adv Nutr. 2021 Jun 1;12(3):793-808. doi: 10.1093/advances/nmaa152. PMID: 33307550; PMCID: PMC8166551.
https://pubmed.ncbi.nlm.nih.gov/33307550/
122. Bauer J, Morley JE, Schols AMWJ, Ferrucci L, Cruz-Jentoft AJ, Dent E, Baracos VE, Crawford JA, Doehner W, Heymsfield SB, Jatoi A, Kalantar-Zadeh K, Lainscak M, Landi F, Laviano A, Mancuso M, Muscaritoli M, Prado CM, Strasser F, von Haehling S, Coats AJS, Anker SD. Sarcopenia: A Time for Action. An SCWD Position Paper. J Cachexia Sarcopenia Muscle. 2019 Oct;10(5):956-961. doi: 10.1002/jcsm.12483. Epub 2019 Sep 15. PMID: 31523937; PMCID: PMC6818450.
https://pubmed.ncbi.nlm.nih.gov/31523937/
123. Nipp RD, Fuchs G, El-Jawahri A, Mario J, Troschel FM, Greer JA, Gallagher ER, Jackson VA, Kambadakone A, Hong TS, Temel JS, Fintelmann FJ. Sarcopenia Is Associated with Quality of Life and Depression in Patients with Advanced Cancer. Oncologist. 2018 Jan;23(1):97-104. doi: 10.1634/theoncologist.2017-0255. Epub 2017 Sep 21. PMID: 28935775; PMCID: PMC5759817.
https://pubmed.ncbi.nlm.nih.gov/28935775/
124. Aversa Z, Costelli P, Muscaritoli M. Cancer-induced muscle wasting: latest findings in prevention and treatment. Ther Adv Med Oncol. 2017 May;9(5):369-382. doi: 10.1177/1758834017698643. Epub 2017 Mar 8. PMID: 28529552; PMCID: PMC5424865.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424865/
125. “Cancer Cachexia: After Years of No Advances, Progress Looks Possible was originally published by the National Cancer Institute.”, August 23, 2022
https://www.cancer.gov/about-cancer/treatment/research/cachexia
126. Nutrition for People Living with Cancer, Cancer Council Australia, 2022
https://www.cancer.org.au/assets/pdf/nutrition-and-cancer-booklet
127. British Nutrition Foundation, Protein, June 2021
https://www.nutrition.org.uk/healthy-sustainable-diets/protein/?level=Health%20professional
128. Protein: What you need to know, British Heart Foundation
https://www.bhf.org.uk/informationsupport/heart-matters-magazine/nutrition/protein
129. DRI Calculator Results, National Agricultural Library U.S. Department of Agriculture Secondary
https://www.nal.usda.gov/human-nutrition-and-food-safety/dri-calculator/results
130. Capitão C, Coutinho D, Neves PM, Capelas ML, Pimenta NM, Santos T, Mäkitie A, Ravasco P. Protein intake and muscle mass maintenance in patients with cancer types with high prevalence of sarcopenia: a systematic review. Support Care Cancer. 2022 Apr;30(4):3007-3015. doi: 10.1007/s00520-021-06633-8. Epub 2021 Oct 25. PMID: 34697674.
https://pubmed.ncbi.nlm.nih.gov/34697674
131. Integr Cancer Ther, 2 (4), 358-64 Dec 2003 Ganoderma Lucidum (Reishi) in Cancer Treatment Daniel Sliva
https://pubmed.ncbi.nlm.nih.gov/14713328/
https://www.researchgate.net/publication/8928055_Ganoderma_Lucidum_Reishi_in_Cancer_Treatment
132. Ahmad MF, Ahmad FA, Khan MI, Alsayegh AA, Wahab S, Alam MI, Ahmed F. Ganoderma lucidum: A potential source to surmount viral infections through β-glucans immunomodulatory and triterpenoids antiviral properties. Int J Biol Macromol. 2021 Sep 30;187:769-779. doi: 10.1016/j.ijbiomac.2021.06.122. Epub 2021 Jun 29. PMID: 34197853.
https://pubmed.ncbi.nlm.nih.gov/34197853/
133. Singh A, Saini RK, Kumar A, Chawla P, Kaushik R. Mushrooms as Nutritional Powerhouses: A Review of Their Bioactive Compounds, Health Benefits, and Value-Added Products. Foods. 2025 Feb 22;14(5):741. doi: 10.3390/foods14050741. PMID: 40077445; PMCID: PMC11899115.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11899115/
134. Yogesh Kumar, Baojun Xu, Bioactive compounds, health benefits, and practical applications of edible mushroom Schizophyllum commune Fr.: A decade-long critical review, Food Chemistry, Volume 492, Part 3, 2025, 145583, ISSN 0308-8146, https://doi.org/10.1016/j.foodchem.2025.145583.
https://www.sciencedirect.com/science/article/abs/pii/S0308814625028341
135. Hazarika DJ, Amao JA, Boro RC and Venturella G (2025) Editorial: Mushrooms as functional foods and nutraceuticals. Front. Sustain. Food Syst. 9:1622356. doi: 10.3389/fsufs.2025.1622356
https://www.frontiersin.org/journals/sustainable-food-systems/articles/10.3389/fsufs.2025.1622356/full
136. Mushrooms in Food Industry and Human Nutrition This special issue belongs to the section “Plant Foods“.
https://www.mdpi.com/journal/foods/special_issues/6955O6B643
137. Olusola Ogidi, Clement, Victor Olusegun Oyetayo, and Bamidele Juliet Akinyele. 2020. ‘Wild Medicinal Mushrooms: Potential Applications in Phytomedicine and Functional Foods’. An Introduction to Mushroom. IntechOpen. doi:10.5772/intechopen.90291.
https://www.intechopen.com/chapters/70347
138. Hsu, KD., Cheng, KC. From nutraceutical to clinical trial: frontiers in Ganoderma development. Appl Microbiol Biotechnol 102, 9037–9051 (2018). https://doi.org/10.1007/s00253-018-9326-5
https://link.springer.com/article/10.1007/s00253-018-9326-5
139. Boh B. Ganoderma lucidum: a potential for biotechnological production of anti-cancer and immunomodulatory drugs. Recent Pat Anticancer Drug Discov. 2013 Sep;8(3):255-87. doi: 10.2174/1574891x113089990036. PMID: 23227951.
https://pubmed.ncbi.nlm.nih.gov/23227951
140. Saltarelli R, Palma F, Gioacchini AM, Calcabrini C, Mancini U, De Bellis R, Stocchi V, Potenza L. Phytochemical composition, antioxidant and antiproliferative activities and effects on nuclear DNA of ethanolic extract from an Italian mycelial isolate of Ganoderma lucidum. J Ethnopharmacol. 2019 Mar 1;231:464-473. doi: 10.1016/j.jep.2018.11.041. Epub 2018 Dec 1. PMID: 30513345.
https://pubmed.ncbi.nlm.nih.gov/30513345/
141. Chugh RM, Mittal P, Mp N, Arora T, Bhattacharya T, Chopra H, Cavalu S, Gautam RK. Fungal Mushrooms: A Natural Compound With Therapeutic Applications. Front Pharmacol. 2022 Jul 13;13:925387. doi: 10.3389/fphar.2022.925387. PMID: 35910346; PMCID: PMC9328747.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9328747/
142. Adaptogenic or Medicinal Mushrooms, Published April 20, 2009, M. Saljoughian, PharmD, PhD Alta Bates Summit Medical Center Department of Pharmacy Services Berkeley, California,
https://www.uspharmacist.com/article/adaptogenic-or-medicinal-mushrooms
143. Adaptogens, Cleveland Clinic, Last reviewed on 02/10/2022.
https://my.clevelandclinic.org/health/drugs/22361-adaptogens
144. What are adaptogens and should you be taking them? February 16, 2022 By uclahealth,
https://www.uclahealth.org/news/article/what-are-adaptogens-and-should-you-be-taking-them
145. Medicinal Mushrooms and their history of therapeutic uses, Sophie Barrett, Medical Herbalist, Naturopath, Faculty of Homeopathy
https://www.facultyofhomeopathy.org/events/medicinal-mushrooms-their-history-of-therapeutic-uses
146. Pharmaceuticals (Basel) . 2020 Aug 29;13(9):E224. doi: 10.3390/ph13090224. Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury Mario Abate, Giacomo Pepe, Rosario Randino, Simona Pisanti, Manuela Giovanna Basilicata, Verdiana Covelli, Maurizio Bifulco, Walter Cabri, Anna Maria D'Ursi, Pietro Campiglia, Manuela Rodriquez
https://pubmed.ncbi.nlm.nih.gov/32872510/
147. Bocharova OA. Adaptogeny kak sredstva profilakticheskoĭ onkologii [Adaptogens as agents for prophylactic oncology]. Vestn Ross Akad Med Nauk. 1999;(5):49-53. Russian. PMID: 10394302.
https://pubmed.ncbi.nlm.nih.gov/10394302/
148. Bocharova OA. Adaptogeny kak sredstva profilakticheskoĭ onkologii [Adaptogens as agents for prophylactic oncology]. Vestn Ross Akad Med Nauk. 1999;(5):49-53. Russian. PMID: 10394302.
https://pubmed.ncbi.nlm.nih.gov/10394302/
149. Peng H, Zhong L, Cheng L, Chen L, Tong R, Shi J, Bai L. Ganoderma lucidum: Current advancements of characteristic components and experimental progress in anti-liver fibrosis. Front Pharmacol. 2023 Jan 9;13:1094405. doi: 10.3389/fphar.2022.1094405. PMID: 36703748; PMCID: PMC9872944.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872944/
150. Sinaeve, S.; Husson, C.; Antoine, M.-H.; Welti, S.; Stévigny, C.; Nortier, J. Nephroprotective Effects of Two Ganoderma Species Methanolic Extracts in an In Vitro Model of Cisplatin Induced Tubulotoxicity. J. Fungi 2022, 8, 1002. https://doi.org/10.3390/jof8101002
https://www.mdpi.com/2309-608X/8/10/1002?type=check_update&version=1
151. Xin, Qi-Hang & Luo, Qi & Wu, Ze-Hong & Zhang, Jiaojiao & Liu, Li-Zhong & Cheng, Yong-Xian. (2019). New Unsaturated Lactones and a Meroterpenoid from Ganoderma lucidum. Natural Product Communications. 14. 1934578X1985881. 10.1177/1934578X19858815.
https://journals.sagepub.com/doi/pdf/10.1177/1934578X19858815
152. Wang L, Li JQ, Zhang J, Li ZM, Liu HG, Wang YZ. Traditional uses, chemical components and pharmacological activities of the genus Ganoderma P. Karst.: a review. RSC Adv. 2020 Nov 18;10(69):42084-42097. doi: 10.1039/d0ra07219b. PMID: 35516772; PMCID: PMC9057998.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057998/
153. Rahman, Mohammad & Hossain, Shahdat & Abdullah, Noorlidah & Aminudin, Norhaniza. (2020). Ganoderma Lucidum Modulates Neuronal Structure and Function Regulatory Protein Expression and Protein-protein Interaction in Alzheimer's Disease Model Animals. 10.21203/rs.3.rs-104135/v1.
https://www.researchgate.net/publication/346006438_Ganoderma_Lucidum_Modulates_Neuronal_Structure_and_Function_Regulatory_Protein_Expression_and_Protein-protein_Interaction_in_Alzheimer%27s_Disease_Model_Animals
154. Interim Revision Announcement Official March 1, 2015, Ganoderma Lucidum Fruiting Body
https://www.uspnf.com/sites/default/files/usp_pdf/EN/USPNF/ganoderma_lucidum_fruiting_body.pdf
155. Herbal Medicines Compendium, Monographs » Final Authorized » Ganoderma lucidum Fruiting Body
https://hmc.usp.org/monographs/ganoderma-lucidum-fruiting-body-1-0
156. Ma Y, Zhang Q, Zhang Q, He H, Chen Z, Zhao Y, Wei D, Kong M, Huang Q. Improved production of polysaccharides in Ganoderma lingzhi mycelia by plasma mutagenesis and rapid screening of mutated strains through infrared spectroscopy. PLoS One. 2018 Sep 21;13(9):e0204266. doi: 10.1371/journal.pone.0204266. PMID: 30240407; PMCID: PMC6150529.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150529/
157. Lindequist U. The merit of medicinal mushrooms from a pharmaceutical point of view. Int J Med Mushrooms. 2013;15(6):517-23. doi: 10.1615/intjmedmushr.v15.i6.10. PMID: 24266376.
https://pubmed.ncbi.nlm.nih.gov/24266376/
158. Wang, Mei and Gerhard Franz. “The role of the European Pharmacopoeia (Ph Eur) in quality control of traditional Chinese herbal medicine in European member states.” Traditional Chinese Medicine 1 (2015): 5-15.
https://epub.uni-regensburg.de/41675/1/The_Role_of_the_European_Pharmacopoeia_Ph_Eur_in_Q%281%29.pdf
159. University of Thessaly Institutional Repository, Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ), Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. Pharmaceutical mushrooms: Ganoderma lucidum, Karalia D., Graikou K., Gortzi O., Chinou I. , 2020
https://ir.lib.uth.gr/xmlui/handle/11615/74387
160. Council of Europe, European Directorate for the Quality of Medicines & HealthCare Newsroom Pharmeuropa issue 30.3 is complete. Comments before 30 September 2018
https://www.edqm.eu/en/-/pharmeuropa-issue-30.3-is-complete.-comments-before-30-september-2018-2
161. EUROPEAN PHARMACOPOEIA 11.0, Ganoderma lucidum
https://www.edqm.eu/documents/52006/467983/Latin+index+-+Ph.+Eur.+11.pdf/c7cbe840-9aed-05af-e2da-8faf69aedd82?t=1656599780218
162. Gurovic MSV, Viceconte FR, Pereyra MT, Bidegain MA, Cubitto MA. DNA damaging potential of Ganoderma lucidum extracts. J Ethnopharmacol. 2018 May 10;217:83-88. doi: 10.1016/j.jep.2018.02.005. Epub 2018 Feb 6. PMID: 29421594.
https://www.sciencedirect.com/science/article/abs/pii/S0378874117346895
163. Front Pharmacol. 2020 Apr 7;11:422. doi: 10.3389/fphar.2020.00422. eCollection 2020. Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety Abdullah Shaito, Duong Thi Bich Thuan, Hoa Thi Phu, Thi Hieu Dung Nguyen, Hiba Hasan, Sarah Halabi, Samar Abdelhady, Gheyath K Nasrallah, Ali H Eid, Gianfranco Pintus
http://europepmc.org/article/MED/32317975
164. Paterson RR. Ganoderma - a therapeutic fungal biofactory. Phytochemistry. 2006 Sep;67(18):1985-2001. doi: 10.1016/j.phytochem.2006.07.004. Epub 2006 Aug 14. PMID: 16905165.
https://pubmed.ncbi.nlm.nih.gov/16905165
165. Sheinfeld Gorin S, Krebs P, Badr H, et al. Meta-analysis of psychosocial interventions to reduce pain in patients with cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 2012 Feb;30(5):539-547. DOI: 10.1200/jco.2011.37.0437. PMID: 22253460; PMCID: PMC6815997.
https://europepmc.org/article/PMC/6815997
166. Deng G. Integrative Medicine Therapies for Pain Management in Cancer Patients. Cancer Journal (Sudbury, Mass.). 2019 Sep/Oct;25(5):343-348. DOI: 10.1097/ppo.0000000000000399. PMID: 31567462; PMCID: PMC6777858.
https://europepmc.org/article/MED/31567462
167. Yang J, Wahner-Roedler DL, Zhou X, et al. Acupuncture for palliative cancer pain management: systematic review. BMJ Supportive & Palliative Care. 2021 Sep;11(3):264-270. DOI: 10.1136/bmjspcare-2020-002638. PMID: 33441387; PMCID: PMC8380897.
https://europepmc.org/article/MED/33441387
168. The analgesic effect of several edible mushrooms, H Wang†, Y Liu†, C Han*, OA Alternative Medicine
https://scispace.com/pdf/the-analgesic-effect-of-several-edible-mushrooms-2mascj4oc1.pdf
169. Elkhateeb, Waill & Elghwas, Dina & Daba, Ghoson. (2023). Anti-Inflammatory agents from Mushrooms: A Review. Open Access Journal of Pharmaceutical Research. 7. 1-7. 10.23880/oajpr-16000278.
https://medwinpublishers.com/OAJPR/anti-inflammatory-agents-from-mushrooms-a-review.pdf
170. Moazzem Hossen SM, Hossain MS, Akbar S, Tahmida U, Mawa J, Uddin Emon N. Wild mushrooms showed analgesic and cytotoxic properties along with phytoconstituent's binding affinity to COX-1, COX-2 and cytochrome P450 2C9. Heliyon. 2021 Sep 14;7(9):e07997. doi: 10.1016/j.heliyon.2021.e07997. PMID: 34585013; PMCID: PMC8455681.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8455681/
171. Fhernanda R. Smiderle, Lorena M. Olsen, Elaine R. Carbonero, Cristiane H. Baggio, Cristina S. Freitas, Rodrigo Marcon, Adair R.S. Santos, Philip A.J. Gorin, Marcello Iacomini, Anti-inflammatory and analgesic properties in a rodent model of a (1→3),(1→6)-linked β-glucan isolated from Pleurotus ulmonarius, European Journal of Pharmacology, Volume 597, Issues 1–3, 2008, Pages 86-91, ISSN 0014-2999, https://doi.org/10.1016/j.ejphar.2008.08.028.
https://www.sciencedirect.com/science/article/abs/pii/S0014299908009059?via%3Dihub
172. Ede, Samuel O. et al. “ANALGESIC AND ANTI INFLAMMATORY ACTIVITIES OF THE ETHANOLIC EXTRACT OF THE MUSHROOM GANODERMA APPLANATUM.” (2012).
https://scispace.com/pdf/analgesic-and-anti-inflammatory-activities-of-the-ethanolic-1ie5fqee1e.pdf
173. Pigoń-Zając, D.; Małecka-Massalska, T.; Łapiński, J.; Prendecka-Wróbel, M. Modern Pro-Health Applications of Medicinal Mushrooms: Insights into the Polyporaceae Family, with a Focus on Cerrena unicolor. Molecules 2025, 30, 4089. https://doi.org/10.3390/molecules30204089
https://www.mdpi.com/1420-3049/30/20/4089
174. Ahmad MF. Ganoderma lucidum: Persuasive biologically active constituents and their health endorsement. Biomed Pharmacother. 2018 Nov;107:507-519. doi: 10.1016/j.biopha.2018.08.036. Epub 2018 Aug 13. PMID: 30114634.
https://pubmed.ncbi.nlm.nih.gov/30114634/
175. Cui X, Zhang Y. Neuropharmacological Effect and Clinical Applications of Ganoderma (Lingzhi). Adv Exp Med Biol. 2019;1182:143-157. doi: 10.1007/978-981-32-9421-9_5. PMID: 31777017.
https://pubmed.ncbi.nlm.nih.gov/31777017/
176. Jinangi Bentharavithana, Jinhai Luo, Baojun Xu, Critical review on signaling pathways of immune boosting effects of edible and medicinal mushrooms, Journal of Future Foods, 2026, , ISSN 2772-5669, https://doi.org/10.1016/j.jfutfo.2026.01.022.
https://www.sciencedirect.com/science/article/pii/S2772566926000406
177. Zhao S, Gao Q, Rong C, Wang S, Zhao Z, Liu Y, Xu J. Immunomodulatory Effects of Edible and Medicinal Mushrooms and Their Bioactive Immunoregulatory Products. J Fungi (Basel). 2020 Nov 8;6(4):269. doi: 10.3390/jof6040269. PMID: 33171663; PMCID: PMC7712035.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7712035/
178. Yang J-y, Tao L, Lou D, Patabendige NM, Ediriweera AN, Liu S, Lu W, Tarafder E, Rapior S and Hapuarachchi KK (2025) Innovative applications of medicinal mushrooms in functional foods and nutraceuticals: a focus on health-boosting beverages. Front. Cell. Infect. Microbiol. 15:1605301. doi: 10.3389/fcimb.2025.1605301
https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2025.1605301/full
179. 8 November 2019, Mushroom extracts could offer an immune cell boost, Griffith University
https://news.griffith.edu.au/2019/11/08/mushroom-extracts-could-offer-an-immune-cell-boost/
180. Ren L, Zhang J, Zhang T. Immunomodulatory activities of polysaccharides from Ganoderma on immune effector cells. Food Chem. 2021 Mar 15;340:127933. doi: 10.1016/j.foodchem.2020.127933. Epub 2020 Aug 26. PMID: 32882476.
https://pubmed.ncbi.nlm.nih.gov/32882476/
181. Wang X, Lin Z. Immunomodulating Effect of Ganoderma (Lingzhi) and Possible Mechanism. Adv Exp Med Biol. 2019;1182:1-37. doi: 10.1007/978-981-32-9421-9_1. PMID: 31777013.
https://pubmed.ncbi.nlm.nih.gov/31777013/
182. Klaunig JE. Oxidative Stress and Cancer. Curr Pharm Des. 2018;24(40):4771-4778. doi: 10.2174/1381612825666190215121712. PMID: 30767733.
https://pubmed.ncbi.nlm.nih.gov/30767733/
183. Ruth W. Mwangi, John M. Macharia, Isabel N. Wagara, Raposa L. Bence, The antioxidant potential of different edible and medicinal mushrooms, Biomedicine & Pharmacotherapy, Volume 147, 2022, 112621, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2022.112621. (https://www.sciencedirect.com/science/article/pii/S0753332222000099)
https://www.sciencedirect.com/science/article/pii/S0753332222000099
184. Podkowa, A., Kryczyk-Poprawa, A., Opoka, W. et al. Culinary–medicinal mushrooms: a review of organic compounds and bioelements with antioxidant activity. Eur Food Res Technol 247, 513–533 (2021). https://doi.org/10.1007/s00217-020-03646-1
https://link.springer.com/article/10.1007/s00217-020-03646-1
185. Ferreira, Isabel & Barros, Lillian & Abreu, Rui. (2009). Antioxidants in Wild Mushrooms. Current Medicinal Chemistry. 16. 1543-1560. 10.2174/092986709787909587.
https://www.researchgate.net/publication/267036608_Antioxidants_in_Wild_Mushrooms
186. Cör D, Knez Ž, Knez Hrnčič M. Antitumour, Antimicrobial, Antioxidant and Antiacetylcholinesterase Effect of Ganoderma Lucidum Terpenoids and Polysaccharides: A Review. Molecules. 2018 Mar 13;23(3):649. doi: 10.3390/molecules23030649. PMID: 29534044; PMCID: PMC6017764.
https://pubmed.ncbi.nlm.nih.gov/29534044/
187. Seweryn E, Ziała A, Gamian A. Health-Promoting of Polysaccharides Extracted from Ganoderma lucidum. Nutrients. 2021 Aug 7;13(8):2725. doi: 10.3390/nu13082725. PMID: 34444885; PMCID: PMC8400705.
https://pubmed.ncbi.nlm.nih.gov/34444885/
188. Kladar NV, Gavarić NS, Božin BN. Ganoderma: insights into anticancer effects. Eur J Cancer Prev. 2016 Sep;25(5):462-71. doi: 10.1097/CEJ.0000000000000204. PMID: 26317382.
https://pubmed.ncbi.nlm.nih.gov/26317382/
189. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002 Dec 19-26;420(6917):860-7. doi: 10.1038/nature01322. PMID: 12490959; PMCID: PMC2803035.
https://pubmed.ncbi.nlm.nih.gov/12490959/
190. Diakos CI, Charles KA, McMillan DC, Clarke SJ. Cancer-related inflammation and treatment effectiveness. Lancet Oncol. 2014 Oct;15(11):e493-503. doi: 10.1016/S1470-2045(14)70263-3. PMID: 25281468.
https://pubmed.ncbi.nlm.nih.gov/25281468/
191. Elinav E, Nowarski R, Thaiss CA, Hu B, Jin C, Flavell RA. Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer. 2013 Nov;13(11):759-71. doi: 10.1038/nrc3611. PMID: 24154716.
https://pubmed.ncbi.nlm.nih.gov/24154716/
192. Bin Du, Fengmei Zhu, Baojun Xu, An insight into the anti-inflammatory properties of edible and medicinal mushrooms, Journal of Functional Foods, Volume 47, 2018, Pages 334-342, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2018.06.003.
https://www.sciencedirect.com/science/article/abs/pii/S1756464618302998
193. Xiaoying M, Peng Z, Hong W, Na G, Jun X, Ying Z, Xun C and Guoli L (2025) From functional foods to immunotherapeutic agents: mechanistic insights into medicinal mushroom bioactives in chronic inflammation management. Front. Nutr. 12:1725297. doi: 10.3389/fnut.2025.1725297
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1725297/full
194. Mori, K., Ouchi, K., & Hirasawa, N. (2015). The anti-inflammatory effects of lion’s mane culinary-medicinal mushroom, Hericium Erinaceus (Higher basidiomycetes) in a coculture system of 3T3-L1 adipocytes and RAW264 macrophages. International Journal of Medicinal Mushrooms, 17(7), 609-618. https://doi.org/10.1615/IntJMedMushrooms.v17.i7.10
https://tohoku.elsevierpure.com/en/publications/the-anti-inflammatory-effects-of-lions-mane-culinary-medicinal-mu/
195. Veerapagu, M., Anandi, A.A., Jeya, K.R., Sankara Narayanan, A. (2026). Anti-Inflammatory Activity of Medicinal Mushrooms. In: Narayanan, A.S., Dharumadurai, D. (eds) Medicinal Mushrooms. Springer Protocols Handbooks. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-4993-0_20
https://link.springer.com/protocol/10.1007/978-1-0716-4993-0_20#citeas
196. Masashi Mizuno, Ken-ichiro Minato, Anti-inflammatory and immunomodulatory properties of polysaccharides in mushrooms, Current Opinion in Biotechnology, Volume 86, 2024, 103076, ISSN 0958-1669, https://doi.org/10.1016/j.copbio.2024.103076.
https://www.sciencedirect.com/science/article/abs/pii/S0958166924000120
197. Geng Y, Zhu S, Lu Z, Xu H, Shi JS, Xu ZH. Anti-inflammatory activity of mycelial extracts from medicinal mushrooms. Int J Med Mushrooms. 2014;16(4):319-25. doi: 10.1615/intjmedmushrooms.v16.i4.20. PMID: 25271860.
https://www.dl.begellhouse.com/journals/708ae68d64b17c52,4c99b516238143af,0b6528d9687446ed.html
198. Geng X, Zhong D, Su L, Lin Z, Yang B. Preventive and therapeutic effect of Ganoderma lucidum on kidney injuries and diseases. Adv Pharmacol. 2020;87:257-276. doi: 10.1016/bs.apha.2019.10.003. Epub 2019 Nov 20. PMID: 32089235.
https://pubmed.ncbi.nlm.nih.gov/32089235/
199. Yin Z, Yang B, Ren H. Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Skin Diseases and Care. Adv Exp Med Biol. 2019;1182:311-321. doi: 10.1007/978-981-32-9421-9_14. PMID: 31777026.
https://pubmed.ncbi.nlm.nih.gov/31777026/
200. Bhardwaj N, Katyal P, Sharma AK. Suppression of inflammatory and allergic responses by pharmacologically potent fungus Ganoderma lucidum. Recent Pat Inflamm Allergy Drug Discov. 2014;8(2):104-17. doi: 10.2174/1872213x08666140619110657. PMID: 24948193.
https://pubmed.ncbi.nlm.nih.gov/24948193/
201. István Zupkó, Walter Jaeger, Zeki Topcu, Chin-Chung Wu, "Anticancer Properties of Natural Products", BioMed Research International, vol. 2015, Article ID 242070, 2 pages, 2015. https://doi.org/10.1155/2015/242070
https://www.hindawi.com/journals/bmri/2015/242070/
202. Xiao Z, Morris-Natschke SL, Lee KH. Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates. Medicinal Research Reviews. 2016 Jan;36(1):32-91. DOI: 10.1002/med.21377. PMID: 26359649; PMCID: PMC4679534.
https://europepmc.org/article/MED/26359649
203. Καλλιέργεια φαρμακευτικών μανιταριών από το Εργαστήριο Μικροβιολογίας και Βιοτεχνολογίας Τροφίμων του ΤΕΙ Θεσσαλίας,
https://www.in.gr/2019/01/26/health/health-news/kalliergeia-farmakeytikon-manitarion-apo-tei-thessalias/
204. Ινστιτούτο Τεχνολογίας Γεωργικών Προϊόντων (I.ΤΕ.ΓΕ.Π)
https://itap.com.gr/edodimon-mykiton-2
205. Πανεπιστήμιο Θεσσαλίας, Τμήμα Ιατρικής, Διπλωματική Εργασία, ΑΙ Χονδρού.
206. Χαροκόπειο Πανεπιστήμιο, Τµήµα Επιστήµης ∆ιαιτολογίας, Πτυχιακή Μελέτη, Ανίχνευση πιθανής πρεβιοτικής δράσης σε µύκητες του γένους Ganoderma, Ροηλίδη Αθανασία
http://estia.hua.gr/browse/17261
207. Εθνικό Μετσόβιο Πολυτεχνείο, Σχολή Χημικών Μηχανικών, Απομόνωση και αξιολόγηση πρωτεϊνικών και υδατανθρακικών συστατικών μανιταριών, Διπλωματική Εργασία, Τσαλτάκη Χρυσούλα
208. Πανεπιστήμιο Αιγαίου, Τμήμα Επιστήμης Τροφίμων και Διατροφής, Πτυχιακή Εργασία, Ο ρόλος της διατροφής στην πρόληψη του καρκίνου, Καρυωτάκη Στυλιανή,
209. Χαροκόπειο Πανεπιστήμιο, Ανίχνευση πιθανής πρεβιοτικής δράσης σε βασιδιομύκητες. Πτυχιακή εργασία, Σεκκίδου, Μικαέλα
https://www.openarchives.gr/aggregator-openarchives/edm/estia/000015-15662/view
210. Γεωπονικό Πανεπιστήμιο Αθηνών, Μεταπτυχιακή εργασία, Μελέτη της βιοδραστικότητας εκχυλισμάτων μυκηλίου και καρποσωμάτων μυκήτων του γένους Ganoderma, Ευσταθιάδου Ευδοξία
https://www.openarchives.gr/aggregator-openarchives/edm/aua/000039-10329_6463
211. ΑΤΕΙ Καλαμάτας, Τμήμα ΤΕΓΕΠ, Πτυχιακή Εργασία, Φαρμακευτικές ιδιότητες βασιδιομυκήτων και ασκομυκήτων, Δημητριάδου Ελένη,
212. Batra P, Sharma AK, Khajuria R. Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. Int J Med Mushrooms. 2013;15(2):127-43. doi: 10.1615/intjmedmushr.v15.i2.20. PMID: 23557365.
https://pubmed.ncbi.nlm.nih.gov/23557365
213. What Are Polyps and Adenomas? University of Rochester Medical Center
https://www.urmc.rochester.edu/conditions-and-treatments/polyps-and-adenomas
214. Adrian C. Bateman, Pathology of colorectal polyps and cancer, Surgery (Oxford), Volume 41, Issue 1, 2023, Pages 15-21, ISSN 0263-9319, https://doi.org/10.1016/j.mpsur.2022.10.011.
https://www.sciencedirect.com/science/article/abs/pii/S0263931922002101
215. Conteduca V, Sansonno D, Russi S, Dammacco F. Precancerous colorectal lesions (Review). Int J Oncol. 2013 Oct;43(4):973-84. doi: 10.3892/ijo.2013.2041. Epub 2013 Jul 29. PMID: 23900573.
https://pubmed.ncbi.nlm.nih.gov/23900573/
216. Munding J, Tannapfel A. Epidemiology of Colorectal Adenomas and Histopathological Assessment of Endoscopic Specimens in the Colorectum. Viszeralmedizin. 2014 Feb;30(1):10-6. doi: 10.1159/000357744. PMID: 26288577; PMCID: PMC4513795.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4513795/
217. Llovet, J.M., Kelley, R.K., Villanueva, A. et al. Hepatocellular carcinoma. Nat Rev Dis Primers 7, 6 (2021). https://doi.org/10.1038/s41572-020-00240-3
https://www.nature.com/articles/s41572-020-00240-3
218. Asafo-Agyei KO, Samant H. Hepatocellular Carcinoma. [Updated 2023 Jun 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK559177/
219. Huitzil-Melendez FD, Capanu M, O'Reilly EM, Duffy A, Gansukh B, Saltz LL, Abou-Alfa GK. Advanced hepatocellular carcinoma: which staging systems best predict prognosis? J Clin Oncol. 2010 Jun 10;28(17):2889-95. doi: 10.1200/JCO.2009.25.9895. Epub 2010 May 10. PMID: 20458042; PMCID: PMC3651603.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3651603/
220. Alves, Rogério & Alves, Daniele & Guz, Betty & Matos, Carla & Viana, Monica & Harriz, Michelle & Terrabuio, Deborah & Kondo, Mario & Gampel, Otávio & Polletti, Paula. (2011). Advanced hepatocellular carcinoma. Review of targeted molecular drugs. Annals of hepatology. 10. 21-7. 10.1016/S1665-2681(19)31582-0.
https://www.elsevier.es/en-revista-annals-hepatology-16-articulo-advanced-hepatocellular-carcinoma-review-targeted-S1665268119315820
221. Kim DW, Talati C, Kim R. Hepatocellular carcinoma (HCC): beyond sorafenib—chemotherapy. J Gastrointest Oncol 2017;8(2):256-265. doi: 10.21037/jgo.2016.09.07
https://jgo.amegroups.org/article/view/9549/html
222. Deng GL, Zeng S, Shen H. Chemotherapy and target therapy for hepatocellular carcinoma: New advances and challenges. World J Hepatol. 2015 Apr 18;7(5):787-98. doi: 10.4254/wjh.v7.i5.787. PMID: 25914779; PMCID: PMC4404384.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4404384/
223. W. Yeo, F.K.F. Mo, J. Koh, A.T.C. Chan, T. Leung, P. Hui, L. Chan, A. Tang, J.J. Lee, T.S.K. Mok, P.B.S. Lai, P.J. Johnson, B. Zee, Quality of life is predictive of survival in patients with unresectable hepatocellular carcinoma, Annals of Oncology, Volume 17, Issue 7, 2006, Pages 1083-1089, ISSN 0923-7534, https://doi.org/10.1093/annonc/mdl065.
https://www.sciencedirect.com/science/article/pii/S0923753419453751
224. Kennedy, A.S., Sangro, B. Nonsurgical Treatment for Localized Hepatocellular Carcinoma. Curr Oncol Rep 16, 373 (2014). https://doi.org/10.1007/s11912-013-0373-x
https://link.springer.com/article/10.1007/s11912-013-0373-x
225. Thomas W. T. Leung, Yehuda Z. Patt, Wan-yee Lau, Stephen K. W. Ho, Simon C. H. Yu, Anthony T. C. Chan, Tony S. K. Mok, Winnie Yeo, Choong-tsek Liew, Nancy W. Y. Leung, Amanda M. Y. Tang, Philip J. Johnson; Complete Pathological Remission Is Possible with Systemic Combination Chemotherapy for Inoperable Hepatocellular Carcinoma. Clin Cancer Res 1 July 1999; 5 (7): 1676–1681.
https://aacrjournals.org/clincancerres/article/5/7/1676/287579/Complete-Pathological-Remission-Is-Possible-with
226. Agirrezabal, I., Pollock, R.F., Carion, P.L. et al. Association of adverse events and quality of life in patients with unresectable hepatocellular carcinoma. Qual Life Res 33, 3377–3386 (2024). https://doi.org/10.1007/s11136-024-03779-w
https://link.springer.com/article/10.1007/s11136-024-03779-w
227. Gandhi S, Khubchandani S, Iyer R. Quality of life and hepatocellular carcinoma. J Gastrointest Oncol 2014;5(4):296-317. doi: 10.3978/j.issn.2078-6891.2014.046
https://jgo.amegroups.org/article/view/2783/html
228. Pathomjaruwat T, Matchim Y, Armer JM. Symptoms and symptom clusters in patients with hepatocellular carcinoma and commonly used instruments: An integrated review. Int J Nurs Sci. 2023 Sep 21;11(1):66-75. doi: 10.1016/j.ijnss.2023.09.009. PMID: 38352278; PMCID: PMC10859590.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10859590/
229. Christian-Miller N, Frenette C. Hepatocellular cancer pain: impact and management challenges. J Hepatocell Carcinoma. 2018 Jul 19;5:75-80. doi: 10.2147/JHC.S145450. PMID: 30050880; PMCID: PMC6055904.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6055904/
230. Sun VC, Sarna L. Symptom management in hepatocellular carcinoma. Clin J Oncol Nurs. 2008 Oct;12(5):759-66. doi: 10.1188/08.CJON.759-766. PMID: 18842532; PMCID: PMC2881685.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2881685/
231. Coriolus versicolor (Yunzhi) Use as Therapy in Advanced Hepatocellular Carcinoma Patients with Poor Liver Function or Who Are Unfit for Standard Therapy Wen Yee Chay, Chee Kian Tham, Han Chong Toh, Hwee Yong Lim, Chee Kiat Tan, Cindy Lim, Who-Whong Wang, and Su-Pin Choo The Journal of Alternative and Complementary Medicine 2017 23:8, 648-652
https://www.liebertpub.com/doi/10.1089/acm.2016.0136
232. Mahdy H, Vadakekut ES, Crotzer D. Endometrial Cancer. [Updated 2024 Apr 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK525981/
233. Liu L, Habeshian TS, Zhang J, Peeri NC, Du M, De Vivo I, Setiawan VW. Differential trends in rising endometrial cancer incidence by age, race, and ethnicity. JNCI Cancer Spectr. 2023 Jan 3;7(1):pkad001. doi: 10.1093/jncics/pkad001. PMID: 36625534; PMCID: PMC9904185.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9904185/
234. Spandidos Publications style Hahne JC, Meyer SR, Dietl J and Honig A: The effect of Cordyceps extract and a mixture of Ganoderma lucidum/Agaricus Blazi Murill extract on human endometrial cancer cell lines in vitro. Int J Oncol 45: 373-382, 2014.
https://www.spandidos-publications.com/10.3892/ijo.2014.2414
235. Tsai YT, Kuo PH, Kuo HP, Hsu CY, Lee YJ, Kuo CL, Liu JY, Lee SL, Kao MC. Ganoderma tsugae suppresses the proliferation of endometrial carcinoma cells via Akt signaling pathway. Environ Toxicol. 2021 Mar;36(3):320-327. doi: 10.1002/tox.23037. Epub 2020 Oct 12. PMID: 33044769.
https://pubmed.ncbi.nlm.nih.gov/33044769/
236. Shi M. The Efficacy of Ganoderma lucidum Extracts on Treating Endometrial Cancer: A Network Pharmacology Approach. Reprod Sci. 2024 Jul;31(7):1881-1894. doi: 10.1007/s43032-024-01500-3. Epub 2024 Mar 6. PMID: 38448739; PMCID: PMC11217070.
https://pubmed.ncbi.nlm.nih.gov/38448739/
237. Biedroń, Rafał & Tangen, Jon-Magnus & Maresz, Katarzyna & Hetland, Geir. (2012). Agaricus blazei Murill - immunomodulatory properties and health benefits. Funct Foods Health Dis. 2. 428-447. 10.31989/ffhd.v2i11.72.
https://ffhdj.com/index.php/ffhd/article/view/72/162
238. TianX, Lun Z, Ito J.Clinical observation on treatment of acute non lymphocytic leukemia with Agaricus blazei. Lanzhou Med Coll 1994;20:169–171.
https://www.springboard4health.com/notebook/health_agaricus_6.html
239. Meade E, Hehir S, Rowan N, Garvey M. Mycotherapy: Potential of Fungal Bioactives for the Treatment of Mental Health Disorders and Morbidities of Chronic Pain. J Fungi (Basel). 2022 Mar 11;8(3):290. doi: 10.3390/jof8030290. PMID: 35330292; PMCID: PMC8954642.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8954642/
240. Molla, G.; Bitew, M. The Future of Cancer Diagnosis and Treatment: Unlocking the Power of Biomarkers and Personalized Molecular-Targeted Therapies. J. Mol. Pathol. 2025, 6, 20. https://doi.org/10.3390/jmp6030020
https://www.mdpi.com/2673-5261/6/3/20
241. Wang X, Zhang H, Chen X. Drug resistance and combating drug resistance in cancer. Cancer Drug Resist. 2019;2(2):141-160. doi: 10.20517/cdr.2019.10. Epub 2019 Jun 19. PMID: 34322663; PMCID: PMC8315569.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8315569/
242. Dhanyamraju PK. Drug resistance mechanisms in cancers: Execution of pro-survival strategies. J Biomed Res. 2024 Feb 28;38(2):95-121. doi: 10.7555/JBR.37.20230248. PMID: 38413011; PMCID: PMC11001593.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11001593/
243. Yue Shi, Joseph Adu-Amankwaah, Qizhong Zhao, Xin Li, Qianxue Yu, Aisha Bushi, Jinxiang Yuan, Rubin Tan, Long non-coding RNAs in drug resistance across the top five cancers: Update on their roles and mechanisms, Heliyon, Volume 10, Issue 5, 2024, e27207, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2024.e27207.
https://www.sciencedirect.com/science/article/pii/S2405844024032389
244. Ingham, J., Ruan, JL. & Coelho, M.A. Breaking barriers: we need a multidisciplinary approach to tackle cancer drug resistance. BJC Rep 3, 11 (2025). https://doi.org/10.1038/s44276-025-00129-2
https://www.nature.com/articles/s44276-025-00129-2
245. To Combat Cancer Treatment Resistance, Researchers Try Leveraging Evolution August 22, 2024, by Carmen Phillips, National Cancer Institute
https://www.cancer.gov/news-events/cancer-currents-blog/2024/cancer-treatment-resistance-engineering-evolution
246. Roda, Elisa, et al. "From a medicinal mushroom blend a direct anticancer effect on triple-negative breast cancer: a preclinical study on lung metastases." Molecules 25.22 (2020): 5400.
Google Scholar
247. De Luca, Fabrizio, et al. "Fighting secondary triple-negative breast cancer in cerebellum: a powerful aid from a medicinal mushrooms blend." Biomedicine & Pharmacotherapy 159 (2023): 114262.
Google Scholar
248. Abdullah, E.; Abidin, N.Z.; Abdullah, N. Cytotoxic Proteins from King Tuber Oyster Medicinal Mushroom, Pleurotus Tuber-Regium (Agaricomycetes), Sclerotium against Human MDA-MB-231 Breast Cancer Cells. Int. J. Med. Mushrooms 2022, 24, 27–40
Google Scholar
249. Wong JH, Ng TB, Chan HHL, Liu Q, Man GCW, Zhang CZ, Guan S, Ng CCW, Fang EF, Wang H, Liu F, Ye X, Rolka K, Naude R, Zhao S, Sha O, Li C, Xia L. Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials. Appl Microbiol Biotechnol. 2020 Jun;104(11):4675-4703. doi: 10.1007/s00253-020-10476-4. Epub 2020 Apr 9. PMID: 32274562.
https://pubmed.ncbi.nlm.nih.gov/32274562/
250. Cai H, Li J, Gu B, Xiao Y, Chen R, Liu X, Xie X, Cao L. Extracts of Cordyceps sinensis inhibit breast cancer cell metastasis via down-regulation of metastasis-related cytokines expression. J Ethnopharmacol. 2018 Mar 25;214:106-112. doi: 10.1016/j.jep.2017.12.012. Epub 2017 Dec 15. PMID: 29253616.
https://pubmed.ncbi.nlm.nih.gov/29253616/
251. Zhong C, Li Y, Li W, Lian S, Li Y, Wu C, Zhang K, Zhou G, Wang W, Xu H, Huang M, Katanaev V, Jia L, Lu Y. Ganoderma lucidum extract promotes tumor cell pyroptosis and inhibits metastasis in breast cancer. Food Chem Toxicol. 2023 Apr;174:113654. doi: 10.1016/j.fct.2023.113654. Epub 2023 Feb 8. PMID: 36758785.
https://pubmed.ncbi.nlm.nih.gov/36758785/
252. Martínez-Montemayor, Michelle M., et al. "Ganoderma lucidum (Reishi) inhibits cancer cell growth and expression of key molecules in inflammatory breast cancer." Nutrition and cancer 63.7 (2011): 1085-1094.
Google Scholar
253. Zhang Y, Sun D, Meng Q, Guo W, Chen Q, Zhang Y. [Corrigendum] Grifola frondosa polysaccharides induce breast cancer cell apoptosis via the mitochondrial-dependent apoptotic pathway. Int J Mol Med. 2022 Nov;50(5):136. doi: 10.3892/ijmm.2022.5192. Epub 2022 Sep 21. Erratum for: Int J Mol Med. 2017 Oct;40(4):1089-1095. doi: 10.3892/ijmm.2017.3081. PMID: 36129150; PMCID: PMC9559173.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9559173/
254. Hseu, You-Cheng, et al. "Antrodia salmonea suppresses invasion and metastasis in triple-negative breast cancer cells by reversing EMT through the NF-κB and Wnt/β-catenin signaling pathway." Food and Chemical Toxicology 124 (2019): 219-230.
https://pubmed.ncbi.nlm.nih.gov/30529123/
255. De Luca, F.; Roda, E.; Rossi, P.; Bottone, M.G. Medicinal Mushrooms in Metastatic Breast Cancer: What Is Their Therapeutic Potential as Adjuvant in Clinical Settings? Curr. Issues Mol. Biol. 2024, 46, 7577-7591. https://doi.org/10.3390/cimb46070450
https://www.mdpi.com/1467-3045/46/7/450
256. Gariboldi MB, Marras E, Ferrario N, Vivona V, Prini P, Vignati F, Perletti G. Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer. Int J Mol Sci. 2023 Jun 14;24(12):10120. doi: 10.3390/ijms241210120. PMID: 37373268; PMCID: PMC10299416.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10299416/
257. Zhang Y, Wang X, Chen T. Efficacy of Huaier granule in patients with breast cancer. Clin Transl Oncol. 2019 May;21(5):588-595. doi: 10.1007/s12094-018-1959-4. Epub 2018 Oct 1. PMID: 30276759.
https://pubmed.ncbi.nlm.nih.gov/30276759/
258. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614. doi: 10.1155/2012/809614. Epub 2011 Dec 10. PMID: 22203880; PMCID: PMC3236089.
https://pubmed.ncbi.nlm.nih.gov/22203880/
259. Karnofsky Performance Status Scale, Jan 19, 2023, WebMD, Buck Christensen; Buck Christensen
https://emedicine.medscape.com/article/2172510-overview?form=fpf
260. Myelodysplastic syndrome (MDS), NHS of UK,
https://www.nhs.uk/conditions/myelodysplastic-syndrome-mds/
261. Bülbül, Hale MDa,*; Kaya, Özge Özer MDb; Karadağ, Fatma Keklik MDa; Olgun, Aybüke MDa; Demirci, Zühal PhDc; Ceylan, Cengiz MDa. Prognostic impact of next-generation sequencing on myelodysplastic syndrome: A single-center experience. Medicine 103(41):p e39909, October 11, 2024. | DOI: 10.1097/MD.0000000000039909
https://journals.lww.com/md-journal/fulltext/2024/10110/prognostic_impact_of_next_generation_sequencing_on.33.aspx
262. Dotson JL, Lebowicz Y. Myelodysplastic Syndrome. [Updated 2022 Jul 18]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK534126/
263. How I Treat Anemia Associated with Lower-Risk Myelodysplastic Syndromes JHOP - June 2021 Vol 11, No 3 - Symptom Management Overview, Myelodysplastic Syndromes Brenna Rowen, PharmD, BCOP
https://jhoponline.com/articles/how-i-treat-anemia-associated-with-lower-risk-myelodysplastic-syndromes
264. Matsunawa, M., Inoue, Y., Yagihashi, K., Aida, Y., Uchida, A., Uemura, Y., Saiki, Y., Takimoto, M., Sano, F., Miura, I. and Arai, A. (2021), The clinicopathological analysis of organising pneumonia in myelodysplastic syndrome: high frequency in der(1;7)(q10; p10). Br. J. Haematol., 194: 214-217. https://doi.org/10.1111/bjh.17473
https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.17473
265. Toma A, Fenaux P, Dreyfus F, Cordonnier C. Infections in myelodysplastic syndromes. Haematologica. 2012 Oct;97(10):1459-70. doi: 10.3324/haematol.2012.063420. Epub 2012 Jun 24. PMID: 22733024; PMCID: PMC3487546.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3487546/
266. Barnea, I.; Luria, L.; Girsault, A.; Dabah, O.; Dudaie, M.; Mirsky, S.K.; Merkel, D.; Shaked, N.T. Analyzing Blood Cells of High-Risk Myelodysplastic Syndrome Patients Using Interferometric Phase Microscopy and Fluorescent Flow Cytometry. Bioengineering 2024, 11, 256. https://doi.org/10.3390/bioengineering11030256
https://www.mdpi.com/2306-5354/11/3/256
267. Kasprzak A, Andresen J, Nachtkamp K, Kündgen A, Schulz F, Strupp C, Kobbe G, MacKenzie C, Timm J, Dietrich S, Gattermann N, Germing U. Infectious Complications in Patients with Myelodysplastic Syndromes: A Report from the Düsseldorf MDS Registry. Cancers (Basel). 2024 Feb 16;16(4):808. doi: 10.3390/cancers16040808. PMID: 38398198; PMCID: PMC10887010.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10887010/
268. Radsak M, Platzbecker U, Schmidt CS, Hofmann W-K, Nolte F. Infectious complications in patients with myelodysplastic syndromes: A review of the literature with emphasis on patients treated with. Eur J Haematol. 2017; 99: 112–118. https://doi.org/10.1111/ejh.12883
https://onlinelibrary.wiley.com/doi/10.1111/ejh.12883
269. Gonçalves AC, Alves R, Baldeiras I, Jorge J, Marques B, Paiva A, Oliveiros B, Cortesão E, Nascimento Costa JM and Sarmento-Ribeiro AB (2021) Oxidative Stress Parameters Can Predict the Response to Erythropoiesis-Stimulating Agents in Myelodysplastic Syndrome Patients. Front. Cell Dev. Biol. 9:701328. doi: 10.3389/fcell.2021.701328
https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.701328/full
270. Jing Q, Zhou C, Zhang J, Zhang P, Wu Y, Zhou J, Tong X, Li Y, Du J, Wang Y. Role of reactive oxygen species in myelodysplastic syndromes. Cell Mol Biol Lett. 2024 Apr 14;29(1):53. doi: 10.1186/s11658-024-00570-0. PMID: 38616283; PMCID: PMC11017617.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11017617/
271. Yuo Akira, Kitagawa Seiichi, Okabe Tetsuro, Urabe Akio, Komatsu Yoshinori, Itoh Seiga, Takaku Fumimaro, Recombinant Human Granulocyte Colony-Stimulating Factor Repairs the Abnormalities of Neutrophils in Patients With Myelodysplastic Syndromes and Chronic Myelogenous Leukemia, Blood, Volume 70, Issue 2, 1987, Pages 404-411, ISSN 0006-4971, https://doi.org/10.1182/blood.V70.2.404.404.
https://www.sciencedirect.com/science/article/pii/S0006497120784302
272. Fuhler, Gwenny Manel. “Neutrophil functions in patients with myelodysplasia: implications of impaired.” (2005).
https://pure.rug.nl/ws/portalfiles/portal/2891599/c4.pdf
273. The role of hematopoietic growth factors in the treatment of patients with Myelodysplastic Syndromes Haema 2012; 3(2): 143-150 by Maria Psillaki, Katerina Pirovolaki, Helen A. Papadaki Hematology Clinic, University Hospital, Heraklion, Crete
https://haema-journal.gr/?p=547
274. Steensma DP. Hematopoietic growth factors in myelodysplastic syndromes. Semin Oncol. 2011 Oct;38(5):635-47. doi: 10.1053/j.seminoncol.2011.04.014. PMID: 21943670.
https://pubmed.ncbi.nlm.nih.gov/21943670/
275. Wesa KM, Cunningham-Rundles S, Klimek VM, Vertosick E, Coleton MI, Yeung KS, Lin H, Nimer S, Cassileth BR. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother. 2015 Feb;64(2):237-47. doi: 10.1007/s00262-014-1628-6. Epub 2014 Oct 29. PMID: 25351719; PMCID: PMC4317517.
https://pubmed.ncbi.nlm.nih.gov/25351719/
276. Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Prz Gastroenterol. 2019;14(2):89-103. doi: 10.5114/pg.2018.81072. Epub 2019 Jan 6. PMID: 31616522; PMCID: PMC6791134.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6791134/
277. Leon Klimeck, Thomas Heisser, Michael Hoffmeister, Hermann Brenner, Colorectal cancer: A health and economic problem, Best Practice & Research Clinical Gastroenterology, Volume 66, 2023, 101839, ISSN 1521-6918, https://doi.org/10.1016/j.bpg.2023.101839.
https://www.sciencedirect.com/science/article/abs/pii/S1521691823000197
278. Siegel RL, Wagle NS, Cercek A, Smith RA, Jemal A. Colorectal cancer statistics, 2023. CA Cancer J Clin. 2023 May-Jun;73(3):233-254. doi: 10.3322/caac.21772. Epub 2023 Mar 1. PMID: 36856579.
https://pubmed.ncbi.nlm.nih.gov/36856579/
279. Ilyas MIM. Epidemiology of Stage IV Colorectal Cancer: Trends in the Incidence, Prevalence, Age Distribution, and Impact on Life Span. Clin Colon Rectal Surg. 2023 Mar 15;37(2):57-61. doi: 10.1055/s-0043-1761447. PMID: 38322602; PMCID: PMC10843881.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10843881/
280. Fritz, H.; Kennedy, D.A.; Ishii, M.; Fergusson, D.; Fernandes, R.; Cooley, K.; Seely, D. Polysaccharide K and Coriolus versicolor Extracts for Lung Cancer. Integr. Cancer Ther. 2015, 14, 201–211.
https://pubmed.ncbi.nlm.nih.gov/25784670/
281. Shahid A, Chen M, Yeung S, Parsa C, Orlando R, Huang Y. The medicinal mushroom Ganoderma lucidum prevents lung tumorigenesis induced by tobacco smoke carcinogens. Front Pharmacol. 2023 Sep 6;14:1244150. doi: 10.3389/fphar.2023.1244150. PMID: 37745066; PMCID: PMC10516555.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10516555/
282. Sangtitanu, T.; Sangtanoo, P.; Srimongkol, P.; Saisavoey, T.; Reamtong, O.; Karnchanatat, A. Peptides obtained from edible mushrooms: Hericium erinaceus offers the ability to scavenge free radicals and induce apoptosis in lung cancer cells in humans. Food Funct. 2020, 11, 4927–4939.
https://pubs.rsc.org/en/content/articlelanding/2020/fo/d0fo00227e/unauth
283. Mihi Yang, Hee-Kyung Jang, Huiwon Kang. How do shiitake and reishi mushrooms work on lung cancer?: A high throughput screening of 3D cell culture. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4553.
https://aacrjournals.org/cancerres/article/83/7_Supplement/4553/724521/Abstract-4553-How-do-shiitake-and-reishi-mushrooms
284. Park, S.E.; Yoo, H.S.; Jin, C.-Y.; Hong, S.H.; Lee, Y.-W.; Kim, B.W.; Lee, S.H.; Kim, W.-J.; Cho, C.K.; Choi, Y.H. Induction of apoptosis and inhibition of telomerase activity in human lung carcinoma cells by the water extract of Cordyceps militaris. Food Chem. Toxicol. 2009, 47, 1667–1675.
https://www.sciencedirect.com/science/article/abs/pii/S0278691509001744
285. Hsu, W.-H.; Qiu, W.-L.; Tsao, S.-M.; Tseng, A.-J.; Lu, M.-K.; Hua, W.-J.; Cheng, H.-C.; Hsu, H.-Y.; Lin, T.-Y. Effects of WSG, a polysaccharide from Ganoderma lucidum, on suppressing cell growth and mobility of lung cancer. Int. J. Biol. Macromol. 2020, 165, 1604–1613.
https://pubmed.ncbi.nlm.nih.gov/33011264/
286. Spandidos Publications style Loganathan J, Jiang J, Smith A, Jedinak A, Thyagarajan-Sahu A, Sandusky GE, Nakshatri H and Sliva D: The mushroom Ganoderma lucidum suppresses breast-to-lung cancer metastasis through the inhibition of pro-invasive genes. Int J Oncol 44: 2009-2015, 2014.
https://www.spandidos-publications.com/10.3892/ijo.2014.2375
287. Lai, Wei & Zainal, Zamri & Daud, Fauzi. (2014). Preliminary study on the potential of polysaccharide from indigenous Tiger's Milk mushroom (Lignosus rhinocerus) as anti-lung cancer agent. 1614. 517-519. 10.1063/1.4895252.
https://www.researchgate.net/publication/299862394_Preliminary_study_on_the_potential_of_polysaccharide_from_indigenous_Tiger%27s_Milk_mushroom_Lignosus_rhinocerus_as_anti-lung_cancer_agent
https://www.spandidos-publications.com/10.3892/ijo.2014.2375
288. Secme M, Kaygusuz O, Eroglu C, Dodurga Y, Colak OF, Atmaca P. Potential Anticancer Activity of the Parasol Mushroom, Macrolepiota procera (Agaricomycetes), against the A549 Human Lung Cancer Cell Line. Int J Med Mushrooms. 2018;20(11):1075-1086. doi: 10.1615/IntJMedMushrooms.2018028589. PMID: 30806231.
https://www.dl.begellhouse.com/journals/708ae68d64b17c52,6e2de2a705b6ffd3,11ce65196897bbc7.html
289. Huo, Xiaowei & Liu, Chenqi & Bai, Xuelian & Li, Wenjia & Li, Jing & Hu, Xuefeng & Cao, Li. (2017). Aqueous extract of Cordyceps sinensis potentiates the antitumor effect of DDP and attenuates therapy-associated toxicity in non-small cell lung cancer via IκBα/NFκB and AKT/MMP2/MMP9 pathways. RSC Adv.. 7. 37743-37754. 10.1039/C7RA04716A.
https://www.researchgate.net/publication/318820879_Aqueous_extract_of_Cordyceps_sinensis_potentiates_the_antitumor_effect_of_DDP_and_attenuates_therapy-associated_toxicity_in_non-small_cell_lung_cancer_via_IkBaNFkB_and_AKTMMP2MMP9_pathways
290. Bizarro A, Ferreira IC, Soković M, van Griensven LJ, Sousa D, Vasconcelos MH, Lima RT. Cordyceps militaris (L.) Link Fruiting Body Reduces the Growth of a Non-Small Cell Lung Cancer Cell Line by Increasing Cellular Levels of p53 and p21. Molecules. 2015 Jul 31;20(8):13927-40. doi: 10.3390/molecules200813927. PMID: 26263965; PMCID: PMC6332316.
https://pubmed.ncbi.nlm.nih.gov/26263965/
291. Khunoana ET, Nkadimeng SM. Current Advances in the Use of Mushrooms as Therapeutics for Lung Cancer: A Review. Molecules. 2025 Mar 14;30(6):1322. doi: 10.3390/molecules30061322. PMID: 40142097; PMCID: PMC11944945.
https://pubmed.ncbi.nlm.nih.gov/40142097/
292. What Is Stomach Cancer? January 22, 2021 American Cancer Society
https://www.cancer.org/cancer/types/stomach-cancer/about/what-is-stomach-cancer.html
293. Menon G, El-Nakeep S, Babiker HM. Gastric Cancer. [Updated 2024 Oct 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK459142/
294. Zaręba KP, Zińczuk J, Dawidziuk T, Pryczynicz A, Guzińska-Ustymowicz K, Kędra B. Stomach cancer in young people - a diagnostic and therapeutic problem. Prz Gastroenterol. 2019;14(4):283-285. doi: 10.5114/pg.2019.90254. Epub 2019 Dec 20. PMID: 31988675; PMCID: PMC6983757.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6983757/
295. Zhang H, Yang W, Tan X, He W, Zhao L, Liu H, Li G. Long-term relative survival of patients with gastric cancer from a large-scale cohort: a period-analysis. BMC Cancer. 2024 Nov 18;24(1):1420. doi: 10.1186/s12885-024-13141-5. PMID: 39558281; PMCID: PMC11571998.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11571998/
296. Gargano ML, Venturella G, Bosco F, Fabrini MG, Gao W, Pecoraro L. The Role of Medicinal Mushrooms in Brain Cancer Therapies: Review. Int J Med Mushrooms. 2021;23(5):13-20. doi: 10.1615/IntJMedMushrooms.2021038277. PMID: 34347991.
https://pubmed.ncbi.nlm.nih.gov/34347991/
297. Zhang M, Zhang Y, Zhang L, Tian Q. Mushroom polysaccharide lentinan for treating different types of cancers: A review of 12 years clinical studies in China. Prog Mol Biol Transl Sci. 2019;163:297-328. doi: 10.1016/bs.pmbts.2019.02.013. Epub 2019 Apr 4. PMID: 31030752.
https://pubmed.ncbi.nlm.nih.gov/31030752/
298. Zeng P, Chen Y, Zhang L, Xing M. Ganoderma lucidum polysaccharide used for treating physical frailty in China. Prog Mol Biol Transl Sci. 2019;163:179-219. doi: 10.1016/bs.pmbts.2019.02.009. Epub 2019 Mar 26. PMID: 31030748.
https://pubmed.ncbi.nlm.nih.gov/31030748/
299. Jakopovic B, Oršolić N, Jakopovich I. Proteomic Research on the Antitumor Properties of Medicinal Mushrooms. Molecules. 2021 Nov 5;26(21):6708. doi: 10.3390/molecules26216708. PMID: 34771120; PMCID: PMC8588050.
https://pubmed.ncbi.nlm.nih.gov/34771120/
300. Tangen JM, Tierens A, Caers J, Binsfeld M, Olstad OK, Trøseid AM, Wang J, Tjønnfjord GE, Hetland G. Immunomodulatory effects of the Agaricus blazei Murrill-based mushroom extract AndoSan in patients with multiple myeloma undergoing high dose chemotherapy and autologous stem cell transplantation: a randomized, double blinded clinical study. Biomed Res Int. 2015;2015:718539. doi: 10.1155/2015/718539. Epub 2015 Jan 18. PMID: 25664323; PMCID: PMC4312620.
https://pubmed.ncbi.nlm.nih.gov/25664323/
Οξεία μη-λεμφοκυτταρική λευχαιμία
1. Biedroń, Rafał & Tangen, Jon-Magnus & Maresz, Katarzyna & Hetland, Geir. (2012). Agaricus blazei Murill – immunomodulatory properties and health benefits. Funct Foods Health Dis. 2. 428-447. 10.31989/ffhd.v2i11.72.
https://ffhdj.com/index.php/ffhd/article/view/72/162
2. Meade E, Hehir S, Rowan N, Garvey M. Mycotherapy: Potential of Fungal Bioactives for the Treatment of Mental Health Disorders and Morbidities of Chronic Pain. J Fungi (Basel). 2022 Mar 11;8(3):290. doi: 10.3390/jof8030290. PMID: 35330292; PMCID: PMC8954642.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8954642/
3. PDQ® Integrative, Alternative, and Complementary Therapies Editorial Board. PDQ Medicinal Mushrooms. Bethesda, MD: National Cancer Institute. Updated July 11, 2024. Available at: https://www.cancer.gov/about-cancer/treatment/cam/patient/mushrooms-pdq. Accessed 27/12/2025. [PMID: 28267306]
4. Molla, G.; Bitew, M. The Future of Cancer Diagnosis and Treatment: Unlocking the Power of Biomarkers and Personalized Molecular-Targeted Therapies. J. Mol. Pathol. 2025, 6, 20. https://doi.org/10.3390/jmp6030020
https://www.mdpi.com/2673-5261/6/3/20
5. Wang X, Zhang H, Chen X. Drug resistance and combating drug resistance in cancer. Cancer Drug Resist. 2019;2(2):141-160. doi: 10.20517/cdr.2019.10. Epub 2019 Jun 19. PMID: 34322663; PMCID: PMC8315569.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8315569/
6. Dhanyamraju PK. Drug resistance mechanisms in cancers: Execution of pro-survival strategies. J Biomed Res. 2024 Feb 28;38(2):95-121. doi: 10.7555/JBR.37.20230248. PMID: 38413011; PMCID: PMC11001593.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11001593/
7. Yue Shi, Joseph Adu-Amankwaah, Qizhong Zhao, Xin Li, Qianxue Yu, Aisha Bushi, Jinxiang Yuan, Rubin Tan, Long non-coding RNAs in drug resistance across the top five cancers: Update on their roles and mechanisms, Heliyon, Volume 10, Issue 5, 2024, e27207, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2024.e27207.
https://www.sciencedirect.com/science/article/pii/S2405844024032389
8. Ingham, J., Ruan, JL. & Coelho, M.A. Breaking barriers: we need a multidisciplinary approach to tackle cancer drug resistance. BJC Rep 3, 11 (2025). https://doi.org/10.1038/s44276-025-00129-2
https://www.nature.com/articles/s44276-025-00129-2
9. To Combat Cancer Treatment Resistance, Researchers Try Leveraging Evolution August 22, 2024, by Carmen Phillips, National Cancer Institute
https://www.cancer.gov/news-events/cancer-currents-blog/2024/cancer-treatment-resistance-engineering-evolution
10. TianX, Lun Z, Ito J.Clinical observation on treatment of acute non lymphocytic leukemia with Agaricus blazei. Lanzhou Med Coll 1994;20:169–171.
https://www.springboard4health.com/notebook/health_agaricus_6.html
Άνοια
1. Survey Finds Brain Health is a Top Priority for Americans a woman smiling at the camera By Paula Croxson, Ph.D. Dana Foundation
https://dana.org/article/survey-finds-brain-health-is-a-top-priority-for-americans/
2. Avan A, Hachinski V, the Brain Health Learn, Act Group. Brain health: Key to health, productivity, and well-being. Alzheimer's Dement. 2022; 18: 1396–1407. https://doi.org/10.1002/alz.12478
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12478
3. Alzheimer's Disease Facts and Figures, Alzheimer's Association
https://www.alz.org/alzheimers-dementia/facts-figures
4. World Health Organisation’s Global Health Estimates reveal dementia as a top three cause of death in Europe, Alzheimer Europe, 09/12/2020
https://www.alzheimer-europe.org/news/world-health-organisations-global-health-estimates-reveal-dementia-top-three-cause-death?language_content_entity=en
5. ReFaey K, Tripathi S, Grewal SS, Bhargav AG, Quinones DJ, Chaichana KL, Antwi SO, Cooper LT, Meyer FB, Dronca RS, Diasio RB, Quinones-Hinojosa A. Cancer Mortality Rates Increasing vs Cardiovascular Disease Mortality Decreasing in the World: Future Implications. Mayo Clin Proc Innov Qual Outcomes. 2021 Jun 8;5(3):645-653. doi: 10.1016/j.mayocpiqo.2021.05.005. PMID: 34195556; PMCID: PMC8240359.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8240359/
6. Lewis JE, Poles J, Shaw DP, et al. The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. Journal of Clinical and Translational Research. 2021 Aug;7(4):575-620. PMID: 34541370; PMCID: PMC8445631.
https://europepmc.org/article/MED/34541370
7. Yiannopoulou KG, Papageorgiou SG. Current and Future Treatments in Alzheimer Disease: An Update. J Cent Nerv Syst Dis. 2020 Feb 29;12:1179573520907397. doi: 10.1177/1179573520907397. PMID: 32165850; PMCID: PMC7050025.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7050025/
8. Neuroscience, Brain Health and Nutrients, Clinical Education
https://www.clinicaleducation.org/brain-health/neuroscience-brain-health-and-nutrients/
9. Stamets P, Zwickey H. Medicinal Mushrooms: Ancient Remedies Meet Modern Science. Integr Med (Encinitas). 2014 Feb;13(1):46-7. PMID: 26770081; PMCID: PMC4684114.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4684114/
10. Zhang S, Zhang S, Tomata Y, et al. Mushroom Consumption and Incident Dementia in Elderly Japanese: The Ohsaki Cohort 2006 Study. Journal of the American Geriatrics Society. 2017 Jul;65(7):1462-1469. DOI: 10.1111/jgs.14812. PMID: 28295137.
https://europepmc.org/article/MED/28295137
11. Yin Z, Chen J, Zhang J, et al. Dietary Patterns Associated with Cognitive Function among the Older People in Underdeveloped Regions: Finding from the NCDFaC Study. Nutrients. 2018 Apr;10(4):E464. DOI: 10.3390/nu10040464. PMID: 29642510; PMCID: PMC5946249.
https://europepmc.org/article/MED/29642510
12. Shang X, Hodge AM, Hill E, Zhu Z, He M. Associations of Dietary Pattern and Sleep Duration with Cognitive Decline in Community-Dwelling Older Adults: A Seven-Year Follow-Up Cohort Study. J Alzheimers Dis. 2021;82(4):1559-1571. doi: 10.3233/JAD-201329. PMID: 34180411.
https://pubmed.ncbi.nlm.nih.gov/34180411/
13. Medicinal Mushrooms (PDQ®)–Patient Version, July 11, 2024, National Cancer Institute at the National Institutes of Health
https://www.cancer.gov/about-cancer/treatment/cam/patient/mushrooms-pdq
14. Sabaratnam V, Kah-Hui W, Naidu M, Rosie David P. Neuronal health - can culinary and medicinal mushrooms help? J Tradit Complement Med. 2013 Jan;3(1):62-8. doi: 10.4103/2225-4110.106549. PMID: 24716157; PMCID: PMC3924982.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3924982/
15. Stephen McMahon, Beth Murinson, CHAPTER 25 - Therapeutic Potential of Neurotrophic Factors, Editor(s): Stephen Waxman, From Neuroscience To Neurology, Academic Press, 2005, Pages 419-431, ISBN 9780127389035, https://doi.org/10.1016/B978-012738903-5/50026-6.
https://www.sciencedirect.com/science/article/abs/pii/B9780127389035500266
16. Ganesan, Anusiya & Udayakumar, Gowthama Prabu & Yamini, N & Sivarajasekar, N. & K, Rambabu & Govindan, Bharath & Banat, Fawzi. (2021). A review of the therapeutic and biological effects of edible and wild mushrooms. Bioengineered. 12. 10.1080/21655979.2021.2001183.
https://www.researchgate.net/publication/355953195_A_review_of_the_therapeutic_and_biological_effects_of_edible_and_wild_mushrooms
17. Mushrooms magnify memory by boosting nerve growth, 10 February 2023, The University of Queensland
ttps://www.uq.edu.au/news/article/2023/02/mushrooms-magnify-memory-boosting-nerve-growth-0
18. Eik LF, Naidu M, David P, Wong KH, Tan YS, Sabaratnam V. Lignosus rhinocerus (Cooke) Ryvarden: A Medicinal Mushroom That Stimulates Neurite Outgrowth in PC-12 Cells. Evid Based Complement Alternat Med. 2012;2012:320308. doi: 10.1155/2012/320308. Epub 2011 Dec 6. PMID: 22203867; PMCID: PMC3235797.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3235797/
19. Khodosevich, K., Monyer, H. Signaling involved in neurite outgrowth of postnatally born subventricular zone neurons in vitro. BMC Neurosci 11, 18 (2010). https://doi.org/10.1186/1471-2202-11-18
https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-11-18
20. Miller KE and Suter DM (2018) An Integrated Cytoskeletal Model of Neurite Outgrowth. Front. Cell. Neurosci. 12:447. doi: 10.3389/fncel.2018.00447
https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2018.00447/full
21. Szućko-Kociuba I, Trzeciak-Ryczek A, Kupnicka P, Chlubek D. Neurotrophic and Neuroprotective Effects of Hericium erinaceus. Int J Mol Sci. 2023 Nov 3;24(21):15960. doi: 10.3390/ijms242115960. PMID: 37958943; PMCID: PMC10650066.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10650066/
22. Aloe L, Rocco ML, Balzamino BO, Micera A. Nerve Growth Factor: A Focus on Neuroscience and Therapy. Curr Neuropharmacol. 2015;13(3):294-303. doi: 10.2174/1570159x13666150403231920. PMID: 26411962; PMCID: PMC4812798.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4812798/
23. Capossela, L.; Gatto, A.; Ferretti, S.; Di Sarno, L.; Graglia, B.; Massese, M.; Soligo, M.; Chiaretti, A. Multifaceted Roles of Nerve Growth Factor: A Comprehensive Review with a Special Insight into Pediatric Perspectives. Biology 2024, 13, 546. https://doi.org/10.3390/biology13070546
https://www.mdpi.com/2079-7737/13/7/546
24. Zhang, Y., Chen, H., Li, R. et al. Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future. Sig Transduct Target Ther 8, 248 (2023). https://doi.org/10.1038/s41392-023-01484-7
https://www.nature.com/articles/s41392-023-01484-7
25. Murphy MP, LeVine H 3rd. Alzheimer's disease and the amyloid-beta peptide. J Alzheimers Dis. 2010;19(1):311-23. doi: 10.3233/JAD-2010-1221. PMID: 20061647; PMCID: PMC2813509.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2813509/
26. Ancient medicine could hold the key to dementia treatment, The University of Queensland
https://stories.uq.edu.au/research/2023/ancient-medicine-could-hold-key-to-dementia-treatment/index.html
27. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytotherapy Research : PTR. 2009 Mar;23(3):367-372. DOI: 10.1002/ptr.2634. PMID: 18844328.
https://europepmc.org/article/MED/18844328
28. Saitsu Y, Nishide A, Kikushima K, Shimizu K, Ohnuki K. Improvement of cognitive functions by oral intake of Hericium erinaceus. Biomedical Research (Tokyo, Japan). 2019 ;40(4):125-131. DOI: 10.2220/biomedres.40.125. PMID: 31413233.
https://europepmc.org/article/MED/31413233
29. Fear of dementia overtakes cancer for older Australians, as new study looks at lifestyle and diet options By medical reporter Sophie Scott and the Specialist Reporting Team's Brooke Wylie, Mon 25 Nov 2019, ABC News
https://www.abc.net.au/news/2019-11-26/dementia-lifestyle-exercise-diet-options-give-hint-at-prevention/11722796
30. Dementia tsunami: Alzheimer's and other dementias to triple by 2050 3 September 2015, University of Sydney
https://www.sydney.edu.au/news-opinion/news/2015/09/03/the-dementia-tsunami--alzheimer-s-disease-and-other-dementias-ex.html
31. Riley RJ, Burgener S, Buckwalter KC. Anxiety and stigma in dementia: a threat to aging in place. Nurs Clin North Am. 2014 Jun;49(2):213-31. doi: 10.1016/j.cnur.2014.02.008. PMID: 24846469; PMCID: PMC4032087.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4032087/
32. Fear of Alzheimer's disease in the French population: impact of age and proximity to the disease Cantegreil-Kallen, Inge et al. International Psychogeriatrics, Volume 24, Issue 1, 108 - 116
https://www.intpsychogeriatrics.org/article/S1041-6102(24)02120-3/fulltext
33. (2014), 2014 Alzheimer's disease facts and figures. Alzheimer's & Dementia, 10: e47-e92. https://doi.org/10.1016/j.jalz.2014.02.001
https://alz-journals.onlinelibrary.wiley.com/doi/10.1016/j.jalz.2014.02.001
34. Watson R, Sanson-Fisher R, Bryant J, Mansfield E. Dementia is the second most feared condition among Australian health service consumers: results of a cross-sectional survey. BMC Public Health. 2023 May 12;23(1):876. doi: 10.1186/s12889-023-15772-y. PMID: 37173717; PMCID: PMC10176813.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10176813/
35. Fear of diseases among people over 50 years of age: A survey, Martin Bystad, Ole Grønli, Camilla Lilleeggen & Per M. Aslaksen Last updated: 16.11.19 Published: 11.12.16, Psykologisk.no
https://psykologisk.no/sp/2016/12/e19/
36. Dementia ‘more feared than cancer’ by older patients 04 August, 2014 By The Press Association, Nursing Times
https://www.nursingtimes.net/older-peoples-nursing/dementia-more-feared-than-cancer-by-older-patients-04-08-2014/
37. Over half of people fear dementia diagnosis, 62 per cent think it means 'life is over' Friday 13 May 2016, Alzheimer's Society
https://www.alzheimers.org.uk/news/2024-11-22/over-half-people-fear-dementia-diagnosis-62-cent-think-it-means-life-over
38. 22 August, 2024, RightCare dementia scenario, NHS England
https://www.england.nhs.uk/long-read/rightcare-dementia-scenario/
39. The later stage of dementia, Alzheimer's Society,
https://www.alzheimers.org.uk/about-dementia/symptoms-and-diagnosis/how-dementia-progresses/later-stages-dementia
40. La Monica MB, Raub B, Ziegenfuss EJ, Hartshorn S, Grdic J, Gustat A, Sandrock J, Ziegenfuss TN. Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion's Mane Extracts on Cognitive Performance. Nutrients. 2023 Dec 6;15(24):5018. doi: 10.3390/nu15245018. PMID: 38140277; PMCID: PMC10745489.
https://pubmed.ncbi.nlm.nih.gov/38140277/
41. Li IC, Chang HH, Lin CH, Chen WP, Lu TH, Lee LY, Chen YW, Chen YP, Chen CC, Lin DP. Prevention of Early Alzheimer's Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study. Front Aging Neurosci. 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PMID: 32581767; PMCID: PMC7283924.
https://pubmed.ncbi.nlm.nih.gov/32581767/
42. Teng EL, Hasegawa K, Homma A, Imai Y, Larson E, Graves A, Sugimoto K, Yamaguchi T, Sasaki H, Chiu D, et al. The Cognitive Abilities Screening Instrument (CASI): a practical test for cross-cultural epidemiological studies of dementia. Int Psychogeriatr. 1994 Spring;6(1):45-58; discussion 62. doi: 10.1017/s1041610294001602. PMID: 8054493.
https://pubmed.ncbi.nlm.nih.gov/8054493/
43. Mini-Mental State Examination (MMSE), March 2024, Healthdirect Australia
https://www.healthdirect.gov.au/mini-mental-state-examination-mmse
44. Guo HJ, Sapra A. Instrumental Activity of Daily Living. [Updated 2022 Nov 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan
https://www.ncbi.nlm.nih.gov/books/NBK553126/
45. 4 Signs You Have a Visual Contrast Sensitivity Problem, International Academy of Low Vision Specialists, | February 27, 2022,
https://ialvs.com/4-signs-you-have-a-visual-contrast-sensitivity-problem/
46. Albumin Blood Test, MedlinePlus
https://medlineplus.gov/lab-tests/albumin-blood-test/
47. Wolters FJ, Zonneveld HI, Licher S, Cremers LGM; Heart Brain Connection Collaborative Research Group; Ikram MK, Koudstaal PJ, Vernooij MW, Ikram MA. Hemoglobin and anemia in relation to dementia risk and accompanying changes on brain MRI. Neurology. 2019 Aug 27;93(9):e917-e926. doi: 10.1212/WNL.0000000000008003. Epub 2019 Jul 31. PMID: 31366722; PMCID: PMC6745727.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6745727/
48. Faux NG, Rembach A, Wiley J, Ellis KA, Ames D, Fowler CJ, Martins RN, Pertile KK, Rumble RL, Trounson B, Masters CL; AIBL Research Group; Bush AI. An anemia of Alzheimer's disease. Mol Psychiatry. 2014 Nov;19(11):1227-34. doi: 10.1038/mp.2013.178. Epub 2014 Jan 14. PMID: 24419041
https://pubmed.ncbi.nlm.nih.gov/24419041/
49. Smith AD, Refsum H, Bottiglieri T, Fenech M, Hooshmand B, McCaddon A, Miller JW, Rosenberg IH, Obeid R. Homocysteine and Dementia: An International Consensus Statement. J Alzheimers Dis. 2018;62(2):561-570. doi: 10.3233/JAD-171042. PMID: 29480200; PMCID: PMC5836397.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5836397/
50. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med. 2002 Feb 14;346(7):476-83. doi: 10.1056/NEJMoa011613. PMID: 11844848.
https://www.nejm.org/doi/full/10.1056/NEJMoa011613
51. Gao, L., Zhang, Y., Sterling, K. et al. Brain-derived neurotrophic factor in Alzheimer’s disease and its pharmaceutical potential. Transl Neurodegener 11, 4 (2022). https://doi.org/10.1186/s40035-022-00279-0
https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-022-00279-0
52. Απεικόνιση του Τανυστή της Διάχυσης (DTI) και Δεσμιδογραφία (Tractography), Α. Μπέκα, Δ. Βεργανελάκης, Π. Τούλας, ΕΛΛΗΝΙΚΗ ΑΚΤΙΝΟΛΟΓΙΑ Τόμος 43, (2):105-115, 2012
https://www.helrad.org/flippingbook/02-12/files/assets/downloads/page0019.pdf
53. Ivanova MV, Zhong A, Turken A, Baldo JV and Dronkers NF (2021) Functional Contributions of the Arcuate Fasciculus to Language Processing. Front. Hum. Neurosci. 15:672665. doi: 10.3389/fnhum.2021.672665
https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2021.672665/full
54. Dalboni da Rocha JL, Bramati I, Coutinho G, Tovar Moll F, Sitaram R. Fractional Anisotropy changes in Parahippocampal Cingulum due to Alzheimer's Disease. Sci Rep. 2020 Feb 14;10(1):2660. doi: 10.1038/s41598-020-59327-2. PMID: 32060334; PMCID: PMC7021702.
ttps://pmc.ncbi.nlm.nih.gov/articles/PMC7021702/
55. Brandalise F, Roda E, Ratto D, Goppa L, Gargano ML, Cirlincione F, Priori EC, Venuti MT, Pastorelli E, Savino E, Rossi P. Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline? J Fungi (Basel). 2023 May 10;9(5):551. doi: 10.3390/jof9050551. PMID: 37233262; PMCID: PMC10218917.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218917/
56. Abdelmoaty, Mai M., Kadry, Rana, Mosley, R. Lee and Gendelman, Howard E.. "Neuroprotective mushrooms" NeuroImmune Pharmacology and Therapeutics, vol. 3, no. 2, 2024, pp. 129-137. https://doi.org/10.1515/nipt-2024-0004
https://www.degruyterbrill.com/document/doi/10.1515/nipt-2024-0004/html
57. Venturella G, Ferraro V, Cirlincione F, Gargano ML. Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials. Int J Mol Sci. 2021 Jan 10;22(2):634. doi: 10.3390/ijms22020634. PMID: 33435246; PMCID: PMC7826851.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7826851
58. Sachchida Nand Rai, Divya Mishra, Payal Singh, Emanuel Vamanu, M.P. Singh, Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases, Biomedicine & Pharmacotherapy, Volume 137, 2021, 111377, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2021.111377.
https://www.sciencedirect.com/science/article/pii/S0753332221001621
59. Li, N.; Li, H.; Liu, Z.; Feng, G.; Shi, C.; Wu, Y. Unveiling the Therapeutic Potentials of Mushroom Bioactive Compounds in Alzheimer’s Disease. Foods 2023, 12, 2972. https://doi.org/10.3390/foods12152972
https://www.mdpi.com/2304-8158/12/15/2972
60. Yanshree; Yu, W.S.; Fung, M.L.; Lee, C.W.; Lim, L.W.; Wong, K.H. The Monkey Head Mushroom and Memory Enhancement in Alzheimer’s Disease. Cells 2022, 11, 2284. https://doi.org/10.3390/cells11152284
https://www.mdpi.com/2073-4409/11/15/2284
61. Vikineswary Sabaratnam, Chia-Wei Phan, Chapter 10 - Neuroactive Components of Culinary and Medicinal Mushrooms With Potential to Mitigate Age-Related Neurodegenerative Diseases, Editor(s): Goutam Brahmachari, In Natural Product Drug Discovery, Discovery and Development of Neuroprotective Agents from Natural Products, Elsevier, 2018, Pages 401-413, ISBN 9780128095935, https://doi.org/10.1016/B978-0-12-809593-5.00010-0.
https://www.sciencedirect.com/science/article/abs/pii/B9780128095935000100
62. Sara Cha, Lynne Bell, Barbara Shukitt-Hale, Claire M. Williams, A review of the effects of mushrooms on mood and neurocognitive health across the lifespan, Neuroscience & Biobehavioral Reviews, Volume 158, 2024, 105548, ISSN 0149-7634, https://doi.org/10.1016/j.neubiorev.2024.105548.
https://www.sciencedirect.com/science/article/pii/S0149763424000162
63. Medicinal Mushrooms Help Fight Cognitive Decline & Protect Your Brain, By Sophie Barret – Hifas da Terra & Patrick Holford, Food for the Brain
https://foodforthebrain.org/medicinal-mushrooms-help-fight-cognitive-decline-protect-your-brain/
64. Lion’s Mane Mushroom, Last updated on July 14, 2025, Alzheimer's Drug Discovery Foundation
https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Lions-Mane-Cognitive-Vitality-For-Researchers.pdf
65. Kim GH, Shim JO. Gut microbiota affects brain development and behavior. Clin Exp Pediatr. 2023 Jul;66(7):274-280. doi: 10.3345/cep.2021.01550. Epub 2022 Nov 8. PMID: 36397259; PMCID: PMC10331547.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10331547/
66. Loh, J.S., Mak, W.Q., Tan, L.K.S. et al. Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases. Sig Transduct Target Ther 9, 37 (2024). https://doi.org/10.1038/s41392-024-01743-1
https://www.nature.com/articles/s41392-024-01743-1
67. Fu J, Qin Y, Xiao L and Dai X (2024) Causal relationship between gut microflora and dementia: a Mendelian randomization study. Front. Microbiol. 14:1306048. doi: 10.3389/fmicb.2023.1306048
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1306048/full
68. Seo, Do., Holtzman, D.M. Current understanding of the Alzheimer’s disease-associated microbiome and therapeutic strategies. Exp Mol Med 56, 86–94 (2024). https://doi.org/10.1038/s12276-023-01146-2
https://www.nature.com/articles/s12276-023-01146-2
69. Professor Sandrine Thuret Dr. rer. nat. FHEA Professor of Neuroscience, King’s College London, 18 October 2023 Scientists discover links between Alzheimer's disease and gut microbiota
https://www.kcl.ac.uk/news/links-between-alzheimers-and-gut-microbiota
70. Bid to prevent gut bacteria triggering Alzheimer’s, Michelle Wisbey 21 May 2024, The Royal Australian College of General Practitioners
https://www1.racgp.org.au/newsgp/clinical/bid-to-prevent-gut-bacteria-triggering-alzheimer-s
71. Changes in human microbiome precede Alzheimer’s cognitive declines From NIH Director’s Blog
ttps://www.alzheimers.gov/news/changes-human-microbiome-precede-alzheimers-cognitive-declines
72. Dementia Australia TM Research Foundation, Research Project By Dr Andrew Shoubridge, Reducing the risk of dementia by keeping gut microbiome healthy
https://www.dementia.org.au/sites/default/files/2024-04/ResearchSheet_DrAndrewShoubridge-2021.pdf
73. Jin, Y., He, J., Fan, D. et al. Application of edible fungi in gut microbiota regulation. npj Sci Food 10, 24 (2026). https://doi.org/10.1038/s41538-025-00671-w
https://www.nature.com/articles/s41538-025-00671-w
74. Zhao J, Hu Y, Qian C, Hussain M, Liu S, Zhang A, He R, Sun P. The Interaction between Mushroom Polysaccharides and Gut Microbiota and Their Effect on Human Health: A Review. Biology (Basel). 2023 Jan 12;12(1):122. doi: 10.3390/biology12010122. PMID: 36671814; PMCID: PMC9856211.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9856211/
75. Yu, C.; Dong, Q.; Chen, M.; Zhao, R.; Zha, L.; Zhao, Y.; Zhang, M.; Zhang, B.; Ma, A. The Effect of Mushroom Dietary Fiber on the Gut Microbiota and Related Health Benefits: A Review. J. Fungi 2023, 9, 1028. https://doi.org/10.3390/jof9101028
https://www.mdpi.com/2309-608X/9/10/1028
76. Zhao Q, Jiang Y, Zhao Q, Patrick Manzi H, Su L, Liu D, Huang X, Long D, Tang Z and Zhang Y (2023) The benefits of edible mushroom polysaccharides for health and their influence on gut microbiota: a review. Front. Nutr. 10:1213010. doi: 10.3389/fnut.2023.1213010
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1213010/full
77. Francis Ayimbila, Suttipun Keawsompong, Unveiling the prebiotic properties of mushrooms in improving gut health and related diseases, Food Bioscience, Volume 70, 2025, 107040, ISSN 2212-4292, https://doi.org/10.1016/j.fbio.2025.107040.
https://www.sciencedirect.com/science/article/abs/pii/S2212429225012167
78. Emerging Role of Mushrooms in Gut Microbiome Revolution September 2024 Authors: Aditya Bhatia
https://www.researchgate.net/publication/384609876_Emerging_Role_of_Mushrooms_in_Gut_Microbiome_Revolution
79. Miaoyu Li, Leilei Yu, Jianxin Zhao, Hao Zhang, Wei Chen, Qixiao Zhai, Fengwei Tian, Role of dietary edible mushrooms in the modulation of gut microbiota, Journal of Functional Foods, Volume 83, 2021, 104538, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2021.104538.
https://www.sciencedirect.com/science/article/pii/S1756464621001870
80. Jayachandran M, Xiao J, Xu B. A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota. Int J Mol Sci. 2017 Sep 8;18(9):1934. doi: 10.3390/ijms18091934. PMID: 28885559; PMCID: PMC5618583.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5618583/
81. Xie XQ, Geng Y, Guan Q, Ren Y, Guo L, Lv Q, Lu ZM, Shi JS, Xu ZH. Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study. Nutrients. 2021 Mar 21;13(3):1008. doi: 10.3390/nu13031008. PMID: 33800983; PMCID: PMC8004025.
https://pubmed.ncbi.nlm.nih.gov/33800983/
82. Compounds for dementia from Hericium erinaceum, Drugs of the Future 2008, 33(2): 149-155 © 2008 Prous Science, S.A.U. or its licensors. All rights reserved. CCC: 0377-8282/2008 DOI: 10.1358/dof.2008.033.02.1173290 Review Article, Hirokazu Kawagishi1,2,* , Cun Zhuang
https://www.creopharm.com.ua/articles_cebrofit/articles_cebrofit_3.pdf
E1. Li IC, Lee LY, Tzeng TT, Chen WP, Chen YP, Shiao YJ, Chen CC. Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines. Behav Neurol. 2018 May 21;2018:5802634. doi: 10.1155/2018/5802634. PMID: 29951133; PMCID: PMC5987239.
https://pubmed.ncbi.nlm.nih.gov/29951133/
E2. Yadav SK, Ir R, Jeewon R, Doble M, Hyde KD, Kaliappan I, Jeyaraman R, Reddi RN, Krishnan J, Li M, Durairajan SSK. A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders. Planta Med. 2020 Nov;86(16):1161-1175. doi: 10.1055/a-1177-4834. Epub 2020 Jul 14. PMID: 32663897.
https://pubmed.ncbi.nlm.nih.gov/32663897
E3. Rai SN, Mishra D, Singh P, Vamanu E, Singh MP. Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases. Biomed Pharmacother. 2021 May;137:111377. doi: 10.1016/j.biopha.2021.111377. Epub 2021 Feb 15. PMID: 33601145.
https://pubmed.ncbi.nlm.nih.gov/33601145
E4. Lewis JE, Poles J, Shaw DP, Karhu E, Khan SA, Lyons AE, Sacco SB, McDaniel HR. The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. J Clin Transl Res. 2021 Aug 4;7(4):575-620. PMID: 34541370; PMCID: PMC8445631.
https://pubmed.ncbi.nlm.nih.gov/34541370
E5. Trovato Salinaro A, Pennisi M, Di Paola R, Scuto M, Crupi R, Cambria MT, Ontario ML, Tomasello M, Uva M, Maiolino L, Calabrese EJ, Cuzzocrea S, Calabrese V. Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer's disease and Alzheimer-linked pathologies: modulation by nutritional mushrooms. Immun Ageing. 2018 Feb 14;15:8. doi: 10.1186/s12979-017-0108-1. PMID: 29456585; PMCID: PMC5813410.
https://pubmed.ncbi.nlm.nih.gov/29456585
E6. Gregory J, Vengalasetti YV, Bredesen DE, Rao RV. Neuroprotective Herbs for the Management of Alzheimer's Disease. Biomolecules. 2021 Apr 8;11(4):543. doi: 10.3390/biom11040543. PMID: 33917843; PMCID: PMC8068256.
https://pubmed.ncbi.nlm.nih.gov/33917843
E7. Phan CW, David P, Naidu M, Wong KH, Sabaratnam V. Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism. Crit Rev Biotechnol. 2015;35(3):355-68. doi: 10.3109/07388551.2014.887649. PMID: 24654802.
https://pubmed.ncbi.nlm.nih.gov/24654802/
E8. Hetland G, Tangen JM, Mahmood F, Mirlashari MR, Nissen-Meyer LSH, Nentwich I, Therkelsen SP, Tjønnfjord GE, Johnson E. Antitumor, Anti-Inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifolafrondosa: A Review of Preclinical and Clinical Studies. Nutrients. 2020 May 8;12(5):1339. doi: 10.3390/nu12051339. PMID: 32397163; PMCID: PMC7285126.
https://pubmed.ncbi.nlm.nih.gov/32397163/
E9. Jiang S, Wang S, Sun Y, Zhang Q. Medicinal properties of Hericium erinaceus and its potential to formulate novel mushroom-based pharmaceuticals. Appl Microbiol Biotechnol. 2014 Sep;98(18):7661-70. doi: 10.1007/s00253-014-5955-5. Epub 2014 Jul 29. PMID: 25070597.
https://pubmed.ncbi.nlm.nih.gov/25070597
E10. He X, Wang X, Fang J, Chang Y, Ning N, Guo H, Huang L, Huang X, Zhao Z. Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion's Mane) mushroom: A review. Int J Biol Macromol. 2017 Apr;97:228-237. doi: 10.1016/j.ijbiomac.2017.01.040. Epub 2017 Jan 10. PMID: 28087447.
https://pubmed.ncbi.nlm.nih.gov/28087447/
E11. Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. J Agric Food Chem. 2015 Aug 19;63(32):7108-23. doi: 10.1021/acs.jafc.5b02914. Epub 2015 Aug 5. PMID: 26244378.
https://pubmed.ncbi.nlm.nih.gov/26244378/
E12. Chong PS, Fung ML, Wong KH, Lim LW. Therapeutic Potential of Hericium erinaceus for Depressive Disorder. Int J Mol Sci. 2019 Dec 25;21(1):163. doi: 10.3390/ijms21010163. PMID: 31881712; PMCID: PMC6982118.
https://pubmed.ncbi.nlm.nih.gov/31881712/
E13. Jiang S, Wang S, Sun Y, Zhang Q. Medicinal properties of Hericium erinaceus and its potential to formulate novel mushroom-based pharmaceuticals. Appl Microbiol Biotechnol. 2014 Sep;98(18):7661-70. doi: 10.1007/s00253-014-5955-5. Epub 2014 Jul 29. PMID: 25070597.
https://pubmed.ncbi.nlm.nih.gov/25070597/
E14. Chen J, Zeng X, Yang YL, Xing YM, Zhang Q, Li JM, Ma K, Liu HW, Guo SX. Genomic and transcriptomic analyses reveal differential regulation of diverse terpenoid and polyketides secondary metabolites in Hericium erinaceus. Sci Rep. 2017 Aug 31;7(1):10151. doi: 10.1038/s41598-017-10376-0. PMID: 28860534; PMCID: PMC5579188.
https://pubmed.ncbi.nlm.nih.gov/28860534/
E15. Khan MA, Tania M, Liu R, Rahman MM. Hericium erinaceus: an edible mushroom with medicinal values. J Complement Integr Med. 2013 May 24;10:/j/jcim.2013.10.issue-1/jcim-2013-0001/jcim-2013-0001.xml. doi: 10.1515/jcim-2013-0001. PMID: 23735479.
https://pubmed.ncbi.nlm.nih.gov/23735479/
E16. Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, Ohnuki K. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res. 2010 Aug;31(4):231-7. doi: 10.2220/biomedres.31.231. PMID: 20834180.
https://pubmed.ncbi.nlm.nih.gov/20834180/
E17. Saitsu Y, Nishide A, Kikushima K, Shimizu K, Ohnuki K. Improvement of cognitive functions by oral intake of Hericium erinaceus. Biomed Res. 2019;40(4):125-131. doi: 10.2220/biomedres.40.125. PMID: 31413233.
https://pubmed.ncbi.nlm.nih.gov/31413233/
E18. Li IC, Chang HH, Lin CH, Chen WP, Lu TH, Lee LY, Chen YW, Chen YP, Chen CC, Lin DP. Prevention of Early Alzheimer's Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study. Front Aging Neurosci. 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PMID: 32581767; PMCID: PMC7283924.
https://pubmed.ncbi.nlm.nih.gov/32581767/
E19. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytotherapy Research : PTR. 2009 Mar;23(3):367-372. DOI: 10.1002/ptr.2634. PMID: 18844328.
https://europepmc.org/article/MED/18844328
Απώλεια βάρους
1. Łysakowska, Paulina & Sobota, A. & Wirkijowska, A.. (2023). Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review. Molecules. 28. 10.3390/molecules28145393.
https://www.researchgate.net/publication/372344884_Medicinal_Mushrooms_Their_Bioactive_Components_Nutritional_Value_and_Application_in_Functional_Food_Production-A_Review
2. Ganesan K, Xu B. Anti-Obesity Effects of Medicinal and Edible Mushrooms. Molecules. 2018 Nov 5;23(11):2880. doi: 10.3390/molecules23112880. PMID: 30400600; PMCID: PMC6278646.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6278646/
3. Precious U. Ezurike, Evelyn Odunola, Tolulope A. Oke, Adewale G. Bakre, Oluwayimika Olumide, OgoOluwa Odetoye, Adenike M. Alege, Oyindamola O. Abiodun, Ganoderma lucidum ethanol extract promotes weight loss and improves depressive-like behaviors in male and female Swiss mice, Physiology & Behavior, Volume 265, 2023, 114155, ISSN 0031-9384, https://doi.org/10.1016/j.physbeh.2023.114155.
https://www.sciencedirect.com/science/article/abs/pii/S0031938423000835
4. Eshita Sharma, Rakesh Bairwa, Priyanka Lal, Sudeepta Pattanayak, Kota Chakrapani, Rajendra Poorvasandhya, Awadhesh Kumar, Muhammad Ahsan Altaf, Rahul Kumar Tiwari, Milan Kumar Lal, Ravinder Kumar, Edible mushrooms trending in food: Nutrigenomics, bibliometric, from bench to valuable applications, Heliyon, Volume 10, Issue 17, 2024, e36963, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2024.e36963.
https://www.sciencedirect.com/science/article/pii/S2405844024129945
5. Choi WS, Kim YS, Park BS, Kim JE, Lee SE. Hypolipidaemic Effect of Hericium erinaceum Grown in Artemisia capillaris on Obese Rats. Mycobiology. 2013 Jun;41(2):94-9. doi: 10.5941/MYCO.2013.41.2.94. Epub 2013 Jun 30. PMID: 23874132; PMCID: PMC3714447.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3714447/
6. Mushroom coffee: Worth a taste? June 4, 2024 By Lindsay Warner, Content Licensing Editor, Harvard Health Publishing
https://www.health.harvard.edu/nutrition/mushroom-coffee-worth-a-taste
7. Grozier CD, Alves VA, Killen LG, Simpson JD, O'Neal EK, Waldman HS. Four Weeks of Hericium erinaceus Supplementation Does Not Impact Markers of Metabolic Flexibility or Cognition. Int J Exerc Sci. 2022 Oct 1;15(2):1366-1380. doi: 10.70252/XZKO8571. PMID: 36582308; PMCID: PMC9762243.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9762243/
8. Teja KS, Suruchi, Rai U, Kumar M, Mohanty O, Roy J, Meshram S. Mushrooms: A Potential Option in the Management of Deficiency and Diseases in Humans. J Pure Appl Microbiol. 2023;17(2):749-760. doi: 10.22207/JPAM.17.2.55
https://microbiologyjournal.org/mushrooms-a-potential-option-in-the-management-of-deficiency-and-diseases-in-humans/
9. Alvandi, H., Ansari, E. ., Kianirad, S. ., Hatamian-Zarmi, A., Mokhtari Hosseini, Z. B., & Ebrahimi-Hosseinzadeh, B. (2022). Medicinal mushrooms as potential therapeutic agents in the treatment of diabetes mellitus: a review with focusing on in vivo and clinical studies. Italian Journal of Mycology, 51(1), 75–96. https://doi.org/10.6092/issn.2531-7342/15023
https://italianmycology.unibo.it/article/view/15023
10. Guggenheim AG, Wright KM, Zwickey HL. Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology. Integr Med (Encinitas). 2014 Feb;13(1):32-44. PMID: 26770080; PMCID: PMC4684115.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4684115/
11. Medicinal Mushrooms (PDQ®)–Patient Version, July 11, 2024, National Cancer Institute, U.S. Department of Health and Human Services
https://www.cancer.gov/about-cancer/treatment/cam/patient/mushrooms-pdq
12. Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan, Xuefei Yang, A concise review of mushrooms antiviral and immunomodulatory properties that may combat against COVID-19, Food Chemistry Advances, Volume 1, 2022, 100023, ISSN 2772-753X, https://doi.org/10.1016/j.focha.2022.100023.
https://www.sciencedirect.com/science/article/pii/S2772753X22000120
13. Do Mushroom Supplements Boost Immunity Against Cancer? Share By Susan Wagner Tuesday, October 22, 2024, Memorial Sloan Kettering Cancer Center
https://www.mskcc.org/news/do-mushroom-supplements-boost-immunity-against-cancer
14. Ruth W. Mwangi, John M. Macharia, Isabel N. Wagara, Raposa L. Bence, The antioxidant potential of different edible and medicinal mushrooms, Biomedicine & Pharmacotherapy, Volume 147, 2022, 112621, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2022.112621.
https://www.sciencedirect.com/science/article/pii/S0753332222000099
15. Podkowa, A., Kryczyk-Poprawa, A., Opoka, W. et al. Culinary–medicinal mushrooms: a review of organic compounds and bioelements with antioxidant activity. Eur Food Res Technol 247, 513–533 (2021). https://doi.org/10.1007/s00217-020-03646-1
https://link.springer.com/article/10.1007/s00217-020-03646-1
16. Elsayed EA, El Enshasy H, Wadaan MA, Aziz R. Mushrooms: a potential natural source of anti-inflammatory compounds for medical applications. Mediators Inflamm. 2014;2014:805841. doi: 10.1155/2014/805841. Epub 2014 Nov 23. PMID: 25505823; PMCID: PMC4258329.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4258329/
17. Drzewiecka, B.; Wessely-Szponder, J.; Świeca, M.; Espinal, P.; Fusté, E.; Fernández-De La Cruz, E. Bioactive Peptides and Other Immunomodulators of Mushroom Origin. Biomedicines 2024, 12, 1483. https://doi.org/10.3390/biomedicines12071483
https://www.mdpi.com/2227-9059/12/7/1483
18. Manna P, Jain SK. Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies. Metab Syndr Relat Disord. 2015 Dec;13(10):423-44. doi: 10.1089/met.2015.0095. PMID: 26569333; PMCID: PMC4808277.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4808277/
19. Theresa V. Rohm, Daniel T. Meier, Jerrold M. Olefsky, Marc Y. Donath, Inflammation in obesity, diabetes, and related disorders, Immunity, Volume 55, Issue 1, 2022, Pages 31-55, ISSN 1074-7613, https://doi.org/10.1016/j.immuni.2021.12.013.
https://www.sciencedirect.com/science/article/pii/S1074761321005495
20. Bilal, Ahmad & Wani, Bilal & Bodha, R & Wani, Ab. Hamid. (2010). Nutritional and medicinal importance of mushrooms. Journal of Medicinal Plants Research. 4. 10.5897/JMPR09.565.
https://www.researchgate.net/publication/266012160_Nutritional_and_medicinal_importance_of_mushrooms
21. Holmes, D. Medicinal mushroom reduces obesity by modulating microbiota. Nat Rev Endocrinol 11, 504 (2015). https://doi.org/10.1038/nrendo.2015.114
https://www.nature.com/articles/nrendo.2015.114#citeas
22. Stamatia-Angeliki Kleftaki, Stamatia Simati, Charalampia Amerikanou, Aristea Gioxari, Chara Tzavara, Georgios I. Zervakis, Nick Kalogeropoulos, Alexander Kokkinos, Andriana C. Kaliora, Pleurotus eryngii improves postprandial glycaemia, hunger and fullness perception, and enhances ghrelin suppression in people with metabolically unhealthy obesity, Pharmacological Research, Volume 175, 2022, 105979, ISSN 1043-6618, https://doi.org/10.1016/j.phrs.2021.105979.
https://www.sciencedirect.com/science/article/abs/pii/S1043661821005636
23. Németh, Z.; Paulinné Bukovics, M.; Sümegi, L.D.; Sturm, G.; Takács, I.; Simon-Szabó, L. The Importance of Edible Medicinal Mushrooms and Their Potential Use as Therapeutic Agents Against Insulin Resistance. Int. J. Mol. Sci. 2025, 26, 827. https://doi.org/10.3390/ijms26020827
https://www.mdpi.com/1422-0067/26/2/827
24. Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, Ohnuki K. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res. 2010 Aug;31(4):231-7. doi: 10.2220/biomedres.31.231. PMID: 20834180.
https://pubmed.ncbi.nlm.nih.gov/20834180/
25. Volume 1, Issue 2 (November 2022), Health Science Monitor 2022, 1(2): 107-108 Does Ganoderma lucidum reduce obesity? Ameneh Marzban , Abdolrazagh Marzban , Payam Emami * Department of Emergency Medical Sciences, School of Paramedical Sciences, Kurdistan University of Medical Sciences, Sanandaj, Iran
https://hsm.umsu.ac.ir/browse.php?a_id=46&sid=1&slc_lang=en
26. Son EH, Jung DH, Shin H, Lee S, Kim Y, Lim HS. Effects of the Intestinal Status and Clinical Factors of Korean Middle-Aged People Through the Consumption of Functional Foods Containing Auricularia auricula-judae Powder: Prospective, Randomized, Open-Label, and Control Comparative Trial. Clin Nutr Res. 2025 Jan 22;14(1):7-16. doi: 10.7762/cnr.2025.14.1.7. PMID: 39968271; PMCID: PMC11832288.
https://pubmed.ncbi.nlm.nih.gov/39968271/
27. Nutrients. 2021 Mar 21;13(3):1008. doi: 10.3390/nu13031008. Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study Xiao-Qian Xie, Yan Geng, Qijie Guan, Yilin Ren, Lin Guo, Qiqi Lv, Zhen-Ming Lu, Jin-Song Shi, Zheng-Hong Xu.
https://pubmed.ncbi.nlm.nih.gov/33800983/
28. Gut microbiome makeup can determine ability to lose weight, UCLA Health, November 24, 2021
https://www.uclahealth.org/news/article/gut-microbiome-makeup-can-determine-ability-to-lose-weight
29. Jian, C., Silvestre, M.P., Middleton, D. et al. Gut microbiota predicts body fat change following a low-energy diet: a PREVIEW intervention study. Genome Med 14, 54 (2022). https://doi.org/10.1186/s13073-022-01053-7
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-022-01053-7
30. Małgorzata Moszak, Marta Pelczyńska, Agnieszka Wesołek, Dominika Stenclik, Paweł Bogdański, Does gut microbiota affect the success of weight loss? Evidence and speculation, Nutrition, Volume 116, 2023, 112111, ISSN 0899-9007, https://doi.org/10.1016/j.nut.2023.112111.
https://www.sciencedirect.com/science/article/pii/S0899900723001405
31. Li, H., Zhang, L., Li, J. et al. Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota. Nat Metab 6, 578–597 (2024). https://doi.org/10.1038/s42255-024-00988-y
https://www.nature.com/articles/s42255-024-00988-y
Ανθεκτική υπέρταση
1. Resistant Hypertension, The Johns Hopkins University
https://www.hopkinsmedicine.org/health/conditions-and-diseases/high-blood-pressure-hypertension/resistant-hypertension
2. Faconti, L., George, J., Partridge, S. et al. Investigation and management of resistant hypertension: British and Irish Hypertension Society position statement. J Hum Hypertens 39, 1–14 (2025). https://doi.org/10.1038/s41371-024-00983-6
https://www.nature.com/articles/s41371-024-00983-6
3. Carey RM, Calhoun DA, Bakris GL, Brook RD, Daugherty SL, Dennison-Himmelfarb CR, Egan BM, Flack JM, Gidding SS, Judd E, Lackland DT, Laffer CL, Newton-Cheh C, Smith SM, Taler SJ, Textor SC, Turan TN, White WB; American Heart Association Professional/Public Education and Publications Committee of the Council on Hypertension; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Genomic and Precision Medicine; Council on Peripheral Vascular Disease; Council on Quality of Care and Outcomes Research; and Stroke Council. Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association. Hypertension. 2018 Nov;72(5):e53-e90. doi: 10.1161/HYP.0000000000000084. PMID: 30354828; PMCID: PMC6530990.
https://www.ahajournals.org/doi/10.1161/HYP.0000000000000084
4. Natale, F.; Franzese, R.; Luisi, E.; Mollo, N.; Marotta, L.; Solimene, A.; D’Elia, S.; Golino, P.; Cimmino, G. The Increasing Problem of Resistant Hypertension: We’ll Manage till Help Comes! Med. Sci. 2024, 12, 53. https://doi.org/10.3390/medsci12040053
https://www.mdpi.com/2076-3271/12/4/53
5. Daugherty SL, Powers JD, Magid DJ, Tavel HM, Masoudi FA, Margolis KL, O'Connor PJ, Selby JV, Ho PM. Incidence and prognosis of resistant hypertension in hypertensive patients. Circulation. 2012 Apr 3;125(13):1635-42. doi: 10.1161/CIRCULATIONAHA.111.068064. Epub 2012 Feb 29. PMID: 22379110; PMCID: PMC3343635.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3343635/
6. White, W., Turan, T., Textor, S., Taler, S., Smith, S., Newton-Cheh, C., Laffer, C., Lackland, D., Judd, E., Gidding, S., Flack, J., Egan, B., Dennison-Himmelfarb, C., Daugherty, S., Brook, R., Bakris, G., Calhoun, D., & Carey, R. (2018). Resistant Hypertension: Detection, Evaluation, and Management A Scientific Statement From the American Heart Association. Hypertension, 72(5), e53-e90. https://doi.org/10.1161/HYP.0000000000000084
https://www.ovid.com/journals/hype/abstract/10.1161/hyp.0000000000000084~resistant-hypertension-detection-evaluation-and-management-a?redirectionsource=fulltextview
Σκλήρυνση κατά πλάκας
1. Multiple Sclerosis, national institutes of neurological disorders and stroke
https://www.ninds.nih.gov/health-information/disorders/multiple-sclerosis
2. Podbielska M, Banik NL, Kurowska E, Hogan EL. Myelin recovery in multiple sclerosis: the challenge of remyelination. Brain Sci. 2013 Aug 28;3(3):1282-324. doi: 10.3390/brainsci3031282. PMID: 24961530; PMCID: PMC4061877.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4061877/
3. David S. Younger, Chapter 6 - Multiple sclerosis: Motor dysfunction, Editor(s): David S. Younger, Handbook of Clinical Neurology, Elsevier, Volume 196, 2023, Pages 119-147, ISSN 0072-9752, ISBN 9780323988179, https://doi.org/10.1016/B978-0-323-98817-9.00016-8.
https://www.sciencedirect.com/science/chapter/handbook/pii/B9780323988179000168
4. Taranu, D., Balz, L.T., Holbrook, J. et al. Cognitive impairment, mood, and fatigue in various multiple sclerosis subtypes: a one-year follow-up study. J Neurol 272, 398 (2025). https://doi.org/10.1007/s00415-025-13115-y
https://link.springer.com/article/10.1007/s00415-025-13115-y
5. Braley TJ, Chervin RD. Fatigue in multiple sclerosis: mechanisms, evaluation, and treatment. Sleep. 2010 Aug;33(8):1061-7. doi: 10.1093/sleep/33.8.1061. PMID: 20815187; PMCID: PMC2910465.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2910465/
6. Ashtari F, Shaygannejad V, Farajzadegan Z, Amin A. Does early-onset multiple sclerosis differ from adult-onset form in Iranian people. J Res Med Sci. 2010 Mar;15(2):94-9. PMID: 21526065; PMCID: PMC3082796.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3082796/
7. Harbo HF, Gold R, Tintoré M. Sex and gender issues in multiple sclerosis. Ther Adv Neurol Disord. 2013 Jul;6(4):237-48. doi: 10.1177/1756285613488434. PMID: 23858327; PMCID: PMC3707353.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3707353/
8. D’Anca, M.; Buccellato, F.R.; Tartaglia, G.M.; Del Fabbro, M.; Muti, P.; Scarpini, E.; Galimberti, D.; Ghezzi, L. Why Is Multiple Sclerosis More Frequent in Women? Role of the Immune System and of Oral and Gut Microbiota. Appl. Sci. 2023, 13, 5881. https://doi.org/10.3390/app13105881
https://www.mdpi.com/2076-3417/13/10/5881
9. Time to reconsider the classification of multiple sclerosis Yamamura, Takashi The Lancet Neurology, Volume 22, Issue 1, 6 - 8
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(22)00469-0/abstract
10. Walton C, King R, Rechtman L, Kaye W, Leray E, Marrie RA, Robertson N, La Rocca N, Uitdehaag B, van der Mei I, Wallin M, Helme A, Angood Napier C, Rijke N, Baneke P. Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition. Mult Scler. 2020 Dec;26(14):1816-1821. doi: 10.1177/1352458520970841. Epub 2020 Nov 11. PMID: 33174475; PMCID: PMC7720355.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7720355/
11. Khan, G., Hashim, M.J. Epidemiology of Multiple Sclerosis: Global, Regional, National and Sub-National-Level Estimates and Future Projections. J Epidemiol Glob Health 15, 21 (2025). https://doi.org/10.1007/s44197-025-00353-6
https://link.springer.com/article/10.1007/s44197-025-00353-6
12. Guerra, T.; Iaffaldano, P. A Window into New Insights on Progression Independent of Relapse Activity in Multiple Sclerosis: Role of Therapies and Current Perspective. Int. J. Mol. Sci. 2025, 26, 884. https://doi.org/10.3390/ijms26030884
https://www.mdpi.com/1422-0067/26/3/884
13. Boutitah-Benyaich, I., Eixarch, H., Villacieros-Álvarez, J. et al. Multiple sclerosis: molecular pathogenesis and therapeutic intervention. Sig Transduct Target Ther 10, 324 (2025). https://doi.org/10.1038/s41392-025-02415-4
https://www.nature.com/articles/s41392-025-02415-4
14. Ferrè L, Filippi M and Esposito F (2020) Involvement of Genetic Factors in Multiple Sclerosis. Front. Cell. Neurosci. 14:612953. doi: 10.3389/fncel.2020.612953
https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2020.612953/full
15. Multiple Sclerosis, national institutes of neurological disorders and stroke
https://www.ninds.nih.gov/health-information/disorders/multiple-sclerosis
16. What Causes MS? National Multiple Sclerosis Society
https://www.nationalmssociety.org/understanding-ms/what-is-ms/what-causes-ms
17. Who develops MS? Nationalmssociety
https://www.nationalmssociety.ae/en/about-ms/who-develops-ms/
18. Is MS a genetic or hereditary condition? Multiple Sclerosis Society (MS Society UK)
https://www.mssociety.org.uk/about-ms/what-is-ms/causes-of-ms
19. Wingerchuk DM. Smoking: effects on multiple sclerosis susceptibility and disease progression. Ther Adv Neurol Disord. 2012 Jan;5(1):13-22. doi: 10.1177/1756285611425694. PMID: 22276073; PMCID: PMC3251901.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3251901/
20. Nishanth K, Tariq E, Nzvere FP, Miqdad M, Cancarevic I. Role of Smoking in the Pathogenesis of Multiple Sclerosis: A Review Article. Cureus. 2020 Aug 5;12(8):e9564. doi: 10.7759/cureus.9564. PMID: 32905534; PMCID: PMC7473606.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7473606/
21. Borros Arneth, Multiple Sclerosis and Smoking, The American Journal of Medicine, Volume 133, Issue 7, 2020, Pages 783-788, ISSN 0002-9343, https://doi.org/10.1016/j.amjmed.2020.03.008.
https://www.sciencedirect.com/science/article/abs/pii/S000293432030228X
22. Manouchehrinia A, Huang J, Hillert J, Alfredsson L, Olsson T, Kockum I and Constantinescu CS (2022) Smoking Attributable Risk in Multiple Sclerosis. Front. Immunol. 13:840158. doi: 10.3389/fimmu.2022.840158
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.840158/full
23. Wang JH, van Haselen R, Wang M, Yang GL, Zhang Z, Friedrich ME, Wang LQ, Zhou YQ, Yin M, Xiao CY, Duan AL, Liu SC, Chen B, Liu JP. Acupuncture for smoking cessation: A systematic review and meta-analysis of 24 randomized controlled trials. Tob Induc Dis. 2019 Jun 4;17:48. doi: 10.18332/tid/109195. PMID: 31516491; PMCID: PMC6662782.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6662782/
24. Wang YY, Liu Z, Chen F, Sun L, Wu Y, Yang JS, Fang JL. Effects of acupuncture on craving after tobacco cessation: a resting-state fMRI study based on the fractional amplitude of low-frequency fluctuation. Quant Imaging Med Surg 2019;9(6):1118-1125. doi: 10.21037/qims.2019.06.07
https://qims.amegroups.org/article/view/26723/html
25. Is it Possible to Quit Smoking With Acupuncture? 09 October 2024, Yeditepe University Hospital
https://yeditepehastaneleri.com/en/health-guide/complementary-medicine/it-possible-quit-smoking-acupuncture
26. Cleveland Clinic, Want to Quit Smoking? Acupuncture Can Help You With Cravings
https://health.clevelandclinic.org/want-to-quit-smoking-acupuncture-can-help-you-with-cravings
27. Smith R. “Let food be thy medicine...”. BMJ. 2004 Jan 24;328(7433):0. PMCID: PMC318470.
https://pmc.ncbi.nlm.nih.gov/articles/PMC318470/
28. Devries S, Willett W, Bonow RO. Nutrition Education in Medical School, Residency Training, and Practice. JAMA. 2019 Apr 9;321(14):1351-1352. doi: 10.1001/jama.2019.1581. PMID: 30896728.
https://greatmed.org/wp-content/uploads/2022/12/Devries-et-al.Nutr-Edu-Residency.2019.JAMA_.pdf
29. May 3, 2018 How much does your doctor actually know about nutrition? By American Heart Association News
https://www.heart.org/en/news/2018/05/03/how-much-does-your-doctor-actually-know-about-nutrition
30. The Deficit of Nutrition Education of Physicians Aggarwal, Monica et al. The American Journal of Medicine, Volume 131, Issue 4, 339 - 345
https://www.amjmed.com/article/S0002-9343(17)31229-9/fulltext
31. Khiri, N. and Howells, K. (2025), Nutritional Education in Medical Curricula and Clinical Practice: A Scoping Review on the Knowledge Deficit Amongst Medical Students and Doctors. Journal of Human Nutrition and Dietetics, 38: e70031. https://doi.org/10.1111/jhn.70031
https://onlinelibrary.wiley.com/doi/full/10.1111/jhn.70031
32. Aggarwal M, Singh Ospina N, Kazory A, Joseph I, Zaidi Z, Ataya A, Agito M, Bubb M, Hahn P, Sattari M. The Mismatch of Nutrition and Lifestyle Beliefs and Actions Among Physicians: A Wake-Up Call. Am J Lifestyle Med. 2019 Nov 5;14(3):304-315. doi: 10.1177/1559827619883603. PMID: 32477033; PMCID: PMC7232894.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7232894/
33. Ocampo-Ordóñez, M.B., Headley, I., Arévalo-Alvear, E.S. et al. Clinical and surgical physician’s perception of nutrition knowledge. BMC Prim. Care 25, 282 (2024). https://doi.org/10.1186/s12875-024-02534-x
https://link.springer.com/article/10.1186/s12875-024-02534-x
34. Most doctors lack adequate training to give informed diet advice Lauren Vogel CMAJ Aug 2018, 190 (31) E945; DOI: 10.1503/cmaj.109-5639
https://www.cmaj.ca/content/190/31/e945
35. Stanford University, Why Medical Schools Need to Focus More on Nutrition This piece appeared in The Wall Street Journal on October 10, 2019. Nutrition BY LLOYD MINOR
https://med.stanford.edu/school/leadership/dean/precision-health-in-the-news/why-medica-schools-need-focus-nutrition.html
36. An area where we can’t neglect nutrition 15 October 2019, University of Auckland
https://www.auckland.ac.nz/en/news/2019/10/15/area-where-we-cant-neglect-nutrition.html
37. Diet and Multiple Sclerosis, National Multiple Sclerosis Society
https://www.nationalmssociety.org/managing-ms/living-with-ms/diet-exercise-and-healthy-behaviors/diet-nutrition
38. Hatami A, Ahmadi-khorram M, Keykhaei F, Esfehani AJ, Nematy M. Association Between the Risk of Multiple Sclerosis and Dietary Proinflammatory/Anti-Inflammatory Food Intake and Dietary Diversity: A Case-Control Study. Clin Nutr Res. 2024 Jan;13(1):61-73. https://doi.org/10.7762/cnr.2024.13.1.61
https://e-cnr.org/DOIx.php?id=10.7762/cnr.2024.13.1.61
39. Rosso, R.; Maglione, A.; Bronzini, M.; Virgilio, E.; Clerico, M.; Rolla, S. Linking Nutrients to Multiple Sclerosis Pathogenesis: Biological Evidence and Clinical Implications. Nutrients 2025, 17, 3414. https://doi.org/10.3390/nu17213414
https://www.mdpi.com/2072-6643/17/21/3414
40. “I see diet almost as another disease modifying therapy. It’s that important.” A qualitative study of dietitian and nursing perspectives on the role of diet and brain health for multiple sclerosis Ware-Maloney, Emma et al. Multiple Sclerosis and Related Disorders, Volume 102, 106613
https://www.msard-journal.com/article/S2211-0348(25)00355-4/fulltext
41. MS Patient’s Pick of the Week’s News: Remyelination, Ocrevus, Mushrooms, Heparin, Exercise admin avatar by admin | October 17, 2016
https://multiplesclerosisnewstoday.com/ians-blog/2016/10/17/ms-patients-pick-weeks-news-remyelination-ocrevus-mushrooms-heparin-exercise/
42. Pourmohammadi G, Moghimi H. New approach of using medicinal mushrooms for managing and curing multiple sclerosis. Fitoterapia. 2025 Sep;185:106684. doi: 10.1016/j.fitote.2025.106684. Epub 2025 Jun 15. PMID: 40527388.
https://pubmed.ncbi.nlm.nih.gov/40527388/
43. Demyelination: Demyelinating diseases and symptoms Last updated May 27, 2022, by Marisa Wexler, MS Fact-checked by Patricia Silva, PhD
https://multiplesclerosisnewstoday.com/demyelination/
44. Demyelinating disease: What can you do about it?, Eoin P. Flanagan, M.B., B.Ch.
https://www.mayoclinic.org/diseases-conditions/multiple-sclerosis/expert-answers/demyelinating-disease/faq-20058521?
45. Demyelinating Disease, Cleveland Clinic, 10/18/2023
https://my.clevelandclinic.org/health/diseases/demyelinating-disease
46. Signs & Symptoms Consistent with Demyelinating Disease, The National Multiple Sclerosis Society,
https://www.nationalmssociety.org/for-professionals/for-healthcare-professionals/diagnosing-ms/demyelinating-disease
47. Shields DC, Schaecher KE, Saido TC, Banik NL. A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11486-91. doi: 10.1073/pnas.96.20.11486. PMID: 10500203; PMCID: PMC18060.
https://www.pnas.org/doi/full/10.1073/pnas.96.20.11486
48. Aditya G. Shivane, Arundhati Chakrabarty, Multiple sclerosis and demyelination, Current Diagnostic Pathology, Volume 13, Issue 3, 2007, Pages 193-202, ISSN 0968-6053, https://doi.org/10.1016/j.cdip.2007.04.003.
49. Lubetzki C, Stankoff B. Demyelination in multiple sclerosis. Handb Clin Neurol. 2014;122:89-99. doi: 10.1016/B978-0-444-52001-2.00004-2. PMID: 24507514; PMCID: PMC7152443.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152443/
50. Zhao X, Jacob C. Mechanisms of Demyelination and Remyelination Strategies for Multiple Sclerosis. Int J Mol Sci. 2023 Mar 28;24(7):6373. doi: 10.3390/ijms24076373. PMID: 37047344; PMCID: PMC10093908.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093908/
51. Lucchinetti CF, Popescu BF, Bunyan RF, Moll NM, Roemer SF, Lassmann H, Brück W, Parisi JE, Scheithauer BW, Giannini C, Weigand SD, Mandrekar J, Ransohoff RM. Inflammatory cortical demyelination in early multiple sclerosis. N Engl J Med. 2011 Dec 8;365(23):2188-97. doi: 10.1056/NEJMoa1100648. PMID: 22150037; PMCID: PMC3282172.
https://www.nejm.org/doi/full/10.1056/NEJMoa1100648
52. What Are Demyelinating Diseases? Medically Reviewed by Christopher Melinosky, MD on September 06, 2022 Written by Rachel Reiff Ellis, WebMD LLC
https://www.webmd.com/multiple-sclerosis/what-are-demyelinating-disorders
53. Demyelination: What Is It and Why Does It Happen?, Medically reviewed by Heidi Moawad, M.D. — Written by The Healthline Editorial Team on March 27, 2014
https://www.healthline.com/health/multiple-sclerosis/demyelination
54. What to Know About Demyelination, the Driving Force of Multiple Sclerosis, By Sara Gaynes LevyMedically reviewed by Mia Tova Minen, MD, MPH March 7, 2022
https://www.self.com/story/demyelination-and-ms
55. Haider L, Simeonidou C, Steinberger G, et al Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron, Journal of Neurology, Neurosurgery & Psychiatry 2014;85:1386-1395.
https://jnnp.bmj.com/content/85/12/1386
Ψωρίαση
1. PLoS One. 2017 Jul 18;12(7):e0181039. doi: 10.1371/journal.pone.0181039. eCollection 2017. An update on psoriasis and metabolic syndrome: A meta-analysis of observational studies. Singh S1, Young P2, Armstrong AW2.
https://www.ncbi.nlm.nih.gov/pubmed/28719618
2. J Am Acad Dermatol. 2015 Aug;73(2):242-8. doi: 10.1016/j.jaad.2015.05.001. Epub 2015 Jun 6. Prevalence of undiagnosed psoriatic arthritis among psoriasis patients: Systematic review and meta-analysis. Villani AP1, Rouzaud M2, Sevrain M3, Barnetche T4, Paul C5, Richard MA6, Beylot-Barry M2, Misery L3, Joly P7, Le Maitre M8, Aractingi S9, Aubin F10, Cantagrel A11, Ortonne JP12, Jullien D13.
https://www.ncbi.nlm.nih.gov/pubmed/26054432
3. Diabetes Metab Syndr. 2019 Mar - Apr;13(2):1405-1412. doi: 10.1016/j.dsx.2019.01.009. Epub 2019 Jan 19. The association between psoriasis and diabetes mellitus: A systematic review and meta-analysis. Mamizadeh M1, Tardeh Z2, Azami M3.
https://www.ncbi.nlm.nih.gov/pubmed/31336500
4. Am J Clin Dermatol. 2019 Feb;20(1):31-40. doi: 10.1007/s40257-018-0394-1. Association Between Psoriasis and Vitiligo: A Systematic Review and Meta-Analysis. Yen H1, Chi CC2,3.
https://www.ncbi.nlm.nih.gov/pubmed/30317450
5. Curr Opin Immunol. 2017 Dec;49:1-8. doi: 10.1016/j.coi.2017.07.007. Epub 2017 Jul 22. Psoriasis: a mixed autoimmune and autoinflammatory disease. Liang Y1, Sarkar MK1, Tsoi LC2, Gudjonsson JE3.
https://www.ncbi.nlm.nih.gov/pubmed/28738209
6. Recent Pat Inflamm Allergy Drug Discov , 8 (2), 104-17 2014 Suppression of Inflammatory and Allergic Responses by Pharmacologically Potent Fungus Ganoderma Lucidum Neha Bhardwaj, Priya Katyal, Anil K Sharma
https://pubmed.ncbi.nlm.nih.gov/24948193
7. Adv Exp Med Biol, 1181, 157-186 2019 Researches and Application of Ganoderma Spores Powder Jianhua Xu, Peng Li
https://pubmed.ncbi.nlm.nih.gov/31677143
8. Oncotarget, 9 (37), 24837-24856 2018 May 15 B-glucans From Grifola Frondosa and Ganoderma Lucidum in Breast Cancer: An Example of Complementary and Integrative Medicine Paola Rossi, Raffaele Difrancia, Vincenzo Quagliariello, Elena Savino, Paolo Tralongo, Cinzia Lucia Randazzo, Massimiliano Berretta
https://pubmed.ncbi.nlm.nih.gov/29872510
9. J Cell Mol Med, 22 (7), 3278-3297 Jul 2018 Chemical, Biochemical, Preclinical and Clinical Studies of Ganoderma Lucidum Polysaccharide as an Approved Drug for Treating Myopathy and Other Diseases in China Pengjiao Zeng, Zhihua Guo, Xuan Zeng, Cui Hao, Yiran Zhang, Meng Zhang, Yong Liu, Hui Li, Juan Li, Lijuan Zhang
https://pubmed.ncbi.nlm.nih.gov/29691994
10. Adv Exp Med Biol , 1182, 39-77 2019 Antitumor Effect of Ganoderma (Lingzhi) Mediated by Immunological Mechanism and Its Clinical Application Zhibin Lin, Lixin Sun
https://pubmed.ncbi.nlm.nih.gov/31777014
11. Integr Med (Encinitas), 13 (1), 32-44 Feb 2014 Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology Alena G Guggenheim, Kirsten M Wright, Heather L Zwickey
https://pubmed.ncbi.nlm.nih.gov/26770080
12. Integr Cancer Ther, 14 (3), 249-57 May 2015 Ganoderma Lucidum for Cancer Treatment: We Are Close but Still Not There Shujie Cheng, Daniel Sliva
https://pubmed.ncbi.nlm.nih.gov/25626896
13. Tumour Biol, 37 (3), 2789-804 Mar 2016 Misconstrued Versatility of Ganoderma Lucidum: A Key Player in Multi-Targeted Cellular Signaling Balraj Singh Gill, Prateek Sharma, Raj Kumar, Sanjeev Kumar
https://pubmed.ncbi.nlm.nih.gov/26715282
14. Recent Pat Anticancer Drug Discov, 8 (3), 255-87 Sep 2013 Ganoderma Lucidum: A Potential for Biotechnological Production of Anti-Cancer and Immunomodulatory Drugs Bojana Boh
https://pubmed.ncbi.nlm.nih.gov/23227951
15. J Nanosci Nanotechnol, 5 (12), 2001-13 Dec 2005 Pharmacological and Anti-Tumor Activities of Ganoderma Spores Processed by Top-Down Approaches Xin Liu, Jiang-Hai Wang, Jian-Ping Yuan
https://pubmed.ncbi.nlm.nih.gov/16430134
16. Acta Pharmacol Sin, 25 (11), 1387-95 Nov 2004 Anti-tumor and Immunoregulatory Activities of Ganoderma Lucidum and Its Possible Mechanisms Zhi-bin Lin, Hui-na Zhang
https://pubmed.ncbi.nlm.nih.gov/15525457
17. Prog Mol Biol Transl Sci, 163, 179-219 2019 Ganoderma Lucidum Polysaccharide Used for Treating Physical Frailty in China Pengjiao Zeng, Yulong Chen, Lijuan Zhang, Maoqing Xing
https://pubmed.ncbi.nlm.nih.gov/31030748
18. Int J Biol Macromol, 121, 1160-1178 Jan 2019 Pharmacological Effects of Natural Ganoderma and Its Extracts on Neurological Diseases: A Comprehensive Review Chen Zhao, Chunchen Zhang, Zheng Xing, Zeeshan Ahmad, Jing-Song Li, Ming-Wei Chang
https://pubmed.ncbi.nlm.nih.gov/30342128
19. Curr Med Chem, 11 (11), 1423-30 Jun 2004 Immunomodulatory and Antimicrobial Effects of Some Traditional Chinese Medicinal Herbs: A Review Benny K H Tan, J Vanitha
https://pubmed.ncbi.nlm.nih.gov/15180575
20. Nutr Cancer, 53 (1), 11-7 2005 Anticancer Effects of Ganoderma Lucidum: A Review of Scientific Evidence John W M Yuen, Mayur Danny I Gohel
https://pubmed.ncbi.nlm.nih.gov/16351502
21. Front Pharmacol, 9, 1217 2018 Oct 25 eCollection 2018 Ganoderma: A Cancer Immunotherapy Review Yu Cao, Xiaowei Xu, Shujing Liu, Linfang Huang, Jian Gu
https://pubmed.ncbi.nlm.nih.gov/30410443
22. Molecules, 23 (3) 2018 Mar 13 Antitumour, Antimicrobial, Antioxidant and Antiacetylcholinesterase Effect of Ganoderma Lucidum Terpenoids and Polysaccharides: A Review Darija Cör, Željko Knez, Maša Knez Hrnčič
https://pubmed.ncbi.nlm.nih.gov/29534044
23. Biomed Pharmacother, 107, 507-519 Nov 2018 Ganoderma Lucidum: Persuasive Biologically Active Constituents and Their Health Endorsement Md Faruque Ahmad
https://pubmed.ncbi.nlm.nih.gov/30114634
24. Adv Exp Med Biol, 1182, 311-321 2019 Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Skin Diseases and Care Zhuming Yin, Baoxue Yang, Huiwen Ren
https://pubmed.ncbi.nlm.nih.gov/31777026
25. Adv Exp Med Biol, 1182, 243-262 2019 Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Renal Diseases and Clinical Applications Xiaoqiang Geng, Dandan Zhong, Limin Su, Baoxue Yang
https://pubmed.ncbi.nlm.nih.gov/31777022
26. Int J Biol Macromol, 150, 765-774 2020 Feb 6[Online ahead of print] Molecular Mechanisms of Bioactive Polysaccharides From Ganoderma Lucidum (Lingzhi), a Review Jiahui Lu, Rongjun He, Peilong Sun, Fuming Zhang, Robert J Linhardt, Anqiang Zhang
https://pubmed.ncbi.nlm.nih.gov/32035956
27. Appl Microbiol Biotechnol, 103 (23-24), 9239-9250 Dec 2019 Ganoderma Proteins and Their Potential Applications in Cosmetics Liu-Dingji Li, Pei-Wen Mao, Ke-Di Shao, Xiao-Hui Bai, Xuan-Wei Zhou
https://pubmed.ncbi.nlm.nih.gov/31659419
28. Molecules, 19 (11), 17478-535 2014 Oct 30 A Comprehensive Review of the Structure Elucidation and Biological Activity of Triterpenoids From Ganoderma Spp Qing Xia, Huazheng Zhang, Xuefei Sun, Haijuan Zhao, Lingfang Wu, Dan Zhu, Guanghui Yang, Yanyan Shao, Xiaoxue Zhang, Xin Mao, Lanzhen Zhang, Gaimei She
https://pubmed.ncbi.nlm.nih.gov/25361420
29. Adv Pharmacol, 87, 257-276 2020 Preventive and Therapeutic Effect of Ganoderma Lucidum on Kidney Injuries and Diseases Xiaoqiang Geng, Dandan Zhong, Limin Su, Zhibin Lin, Baoxue Yang
https://pubmed.ncbi.nlm.nih.gov/32089235
30. Acta Medica (Hradec Kralove), 42 (4), 123-5 1999 Anti-inflammatory Triterpenoids From Mysterious Mushroom Ganoderma Lucidum and Their Potential Possibility in Modern Medicine J Patocka
https://pubmed.ncbi.nlm.nih.gov/10812678
31. Curr Pharm Biotechnol, 10 (8), 717-42 Dec 2009 Ganoderma Lucidum: A Potent Pharmacological Macrofungus Bhagwan S Sanodiya, Gulab Singh Thakur, Rakesh K Baghel, G B K S Prasad, P S Bisen
https://pubmed.ncbi.nlm.nih.gov/19939212
32. Clin Rheumatol, 38 (10), 2659-2671 Oct 2019 Association of Total Oxidant Status, Total Antioxidant Status, and Malondialdehyde and Catalase Levels With Psoriasis: A Systematic Review and Meta-Analysis YouCan Zhang, ZhongSheng Li, Yun Ma, Zhen Mu
33. Eur J Cancer Prev, 25 (5), 462-71 Sep 2016 Ganoderma: Insights Into Anticancer Effects Nebojša V Kladar, Neda S Gavarić, Biljana N Božin
https://pubmed.ncbi.nlm.nih.gov/26317382
34. Phytochemistry, 114, 38-55 Jun 2015 Chemical Features of Ganoderma Polysaccharides With Antioxidant, Antitumor and Antimicrobial Activities Isabel C F R Ferreira, Sandrina A Heleno, Filipa S Reis, Dejan Stojkovic, Maria João R P Queiroz, M Helena Vasconcelos, Marina Sokovic
https://pubmed.ncbi.nlm.nih.gov/25457487
35. Adv Exp Med Biol, 1182, 79-118 2019 Cellular and Molecular Mechanism of Ganoderma (Lingzhi) Against Tumor Yu Sun, Lixin Sun
https://pubmed.ncbi.nlm.nih.gov/31777015
36. Appl Microbiol Biotechnol, 103 (23-24), 9239-9250 Dec 2019 Ganoderma Proteins and Their Potential Applications in Cosmetics Liu-Dingji Li, Pei-Wen Mao, Ke-Di Shao, Xiao-Hui Bai, Xuan-Wei Zhou
https://pubmed.ncbi.nlm.nih.gov/31659419
37. Adv Exp Med Biol, 1182, 181-199 2019 Protective Effect of Ganoderma (Lingzhi) on Cardiovascular System Jia Meng, Baoxue Yang
https://pubmed.ncbi.nlm.nih.gov/31777019
38. Curr Pharm Biotechnol, 10 (8), 717-42 Dec 2009 Ganoderma Lucidum: A Potent Pharmacological Macrofungus Bhagwan S Sanodiya, Gulab Singh Thakur, Rakesh K Baghel, G B K S Prasad, P S Bisen
https://pubmed.ncbi.nlm.nih.gov/19939212
39. Prog Mol Biol Transl Sci, 163, 179-219 2019 Ganoderma Lucidum Polysaccharide Used for Treating Physical Frailty in China Pengjiao Zeng, Yulong Chen, Lijuan Zhang, Maoqing Xing
https://pubmed.ncbi.nlm.nih.gov/31030748
40. Adv Pharmacol, 87, 257-276 2020 Preventive and Therapeutic Effect of Ganoderma Lucidum on Kidney Injuries and Diseases Xiaoqiang Geng, Dandan Zhong, Limin Su, Zhibin Lin, Baoxue Yang
https://pubmed.ncbi.nlm.nih.gov/32089235
41. Molecules, 19 (11), 17478-535 2014 Oct 30 A Comprehensive Review of the Structure Elucidation and Biological Activity of Triterpenoids From Ganoderma Spp Qing Xia, Huazheng Zhang, Xuefei Sun, Haijuan Zhao, Lingfang Wu, Dan Zhu, Guanghui Yang, Yanyan Shao, Xiaoxue Zhang, Xin Mao, Lanzhen Zhang, Gaimei She
https://pubmed.ncbi.nlm.nih.gov/25361420
42. Adv Exp Med Biol, 1182, 299-309 2019 Anti-aging Effect of Ganoderma (Lingzhi) With Health and Fitness Yan Pan, Zhibin Lin
https://pubmed.ncbi.nlm.nih.gov/31777025
43. Zhongguo Zhong Yao Za Zhi, 44 (5), 905-911 Mar 2019 [Pharmacokinetics of Ganoderic Acids] [Article in Chinese] Fei-Fei Zhang, Ru-Ming Liu
https://pubmed.ncbi.nlm.nih.gov/30989848
44. Cochrane Database Syst Rev. 2017 Dec 22;12:CD011535. doi: 10.1002/14651858.CD011535.pub2. Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis. Sbidian E1, Chaimani A, Garcia-Doval I, Do G, Hua C, Mazaud C, Droitcourt C, Hughes C, Ingram JR, Naldi L, Chosidow O, Le Cleach L.
https://www.ncbi.nlm.nih.gov/pubmed/29271481
45. J Am Acad Dermatol. 2017 Sep;77(3):425-440.e2. doi: 10.1016/j.jaad.2017.05.019. Psoriasis and suicidality: A systematic review and meta-analysis. Singh S1, Taylor C2, Kornmehl H3, Armstrong AW4.
https://www.ncbi.nlm.nih.gov/pubmed/28807109
46. JAMA Dermatol. 2018 Dec 1;154(12):1417-1423. doi: 10.1001/jamadermatol.2018.3631. Association of Psoriasis With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis. Fu Y1, Lee CH2, Chi CC1,3.
https://www.ncbi.nlm.nih.gov/pubmed/30422277
47. J Sex Med. 2018 Jun;15(6):839-847. doi: 10.1016/j.jsxm.2018.04.630. Epub 2018 May 4. Association Between Psoriasis and Erectile Dysfunction: A Meta-Analysis. Wu T1, Duan X2, Chen S1, Chen X1, Yu R3, Yu X4.
https://www.ncbi.nlm.nih.gov/pubmed/29735408
48. Allergy Asthma Proc. 2018 Mar 1;39(2):103-109. doi: 10.2500/aap.2018.39.4109. Association between psoriasis and asthma risk: A meta-analysis. Wang J1, Ke R, Shi W, Yan X, Wang Q, Zhang Q, Chai L, Li M.
https://www.ncbi.nlm.nih.gov/pubmed/29490768
49. Lasers Med Sci, 33 (1), 173-180 Jan 2018 A Clinical Review of Phototherapy for Psoriasis Ping Zhang, Mei X Wu
https://pubmed.ncbi.nlm.nih.gov/29067616/
http://europepmc.org/article/MED/29067616
50. J Eur Acad Dermatol Venereol, 31 (12), 1999-2009 Dec 2017 Depression and Suicidality in Psoriasis: Review of the Literature Including the Cytokine Theory of Depression J Koo, L B Marangell, M Nakamura, A Armstrong, C Jeon, T Bhutani, J J Wu
https://www.ncbi.nlm.nih.gov/pubmed/28681405
51. South Med J, 110 (2), 97-100 Feb 2017 Psoriasis and Cardiomyopathy: A Review of the Literature Taimoor Hashim, Amier Ahmad, Ayesha Chaudry, Rami Khouzam
https://www.ncbi.nlm.nih.gov/pubmed/28158878
52. Can Fam Physician, 63 (4), 278-285 Apr 2017 Diagnosis and Management of Psoriasis Whan B Kim, Dana Jerome, Jensen Yeung
https://www.ncbi.nlm.nih.gov/pubmed/28404701
http://europepmc.org/article/MED/28404701
53. Int J Mol Sci, 20 (6) 2019 Mar 23 Psoriasis Pathogenesis and Treatment Adriana Rendon, Knut Schäkel
https://www.ncbi.nlm.nih.gov/pubmed/30909615
http://europepmc.org/article/MED/30909615
54. Am Fam Physician, 87 (9), 626-33 2013 May 1 Psoriasis Nancy Weigle, Sarah McBane
https://www.ncbi.nlm.nih.gov/pubmed/23668525
55. Am J Manag Care, 22 (8 Suppl), s216-24 Jun 2016 Psoriasis and Psoriatic Arthritis Overview Alan Menter
https://www.ncbi.nlm.nih.gov/pubmed/27356193
56. Paediatr Drugs, 17 (5), 373-84 Oct 2015 Psoriasis in Children and Adolescents: Diagnosis, Management and Comorbidities I M G J Bronckers, A S Paller, M J van Geel, P C M van de Kerkhof, M M B Seyger
https://www.ncbi.nlm.nih.gov/pubmed/26072040
http://europepmc.org/article/MED/26072040
57. Lancet, 370 (9583), 263-271 2007 Jul 21 Pathogenesis and Clinical Features of Psoriasis Christopher Em Griffiths, Jonathan Nwn Barker
https://www.ncbi.nlm.nih.gov/pubmed/17658397
58. Models in the Research Process of Psoriasis. Bocheńska K, Smolińska E, Moskot M, Jakóbkiewicz-Banecka J, Gabig-Cimińska M
http://europepmc.org/article/MED/29186769
59. Front Immunol, 9, 579 2018 Apr 5 eCollection 2018 Systemic Inflammation and Cardiovascular Comorbidity in Psoriasis Patients: Causes and Consequences Wolf-Henning Boehncke
https://www.ncbi.nlm.nih.gov/pubmed/29675020
60. Ann Rheum Dis, 64 Suppl 2 (Suppl 2), ii18-23; discussion ii24-5 Mar 2005 Psoriasis: Epidemiology, Clinical Features, and Quality of Life R G B Langley, G G Krueger, C E M Griffiths
https://www.ncbi.nlm.nih.gov/pubmed/15708928
61. Int J Mol Sci, 20 (18) 2019 Sep 5 Risk Factors for the Development of Psoriasis Koji Kamiya, Megumi Kishimoto, Junichi Sugai, Mayumi Komine, Mamitaro Ohtsuki
https://www.ncbi.nlm.nih.gov/pubmed/31491865
http://europepmc.org/article/MED/31491865
62. Clin Exp Rheumatol, 33 (5 Suppl 93), S2-6 Sep-Oct 2015 Pathogenesis and Treatment of Psoriasis: Exploiting Pathophysiological Pathways for Precision Medicine Wisam Alwan, Frank O Nestle
https://www.ncbi.nlm.nih.gov/pubmed/26472336
63. Actas Dermosifiliogr, 110 (1), 12-19 Jan-Feb 2019 Psoriasis and Depression: The Role of Inflammation [Article in English, Spanish] S González-Parra, E Daudén
https://www.ncbi.nlm.nih.gov/pubmed/30509759
64. J Dermatol, 43 (1), 4-8 Jan 2016 Psoriasis: Behind the Scenes Masutaka Furue, Takafumi Kadono
https://www.ncbi.nlm.nih.gov/pubmed/26782000
65. Lakartidningen, 114 2017 Nov 21 [Psoriasis in Childhood and Adolescence] [Article in Swedish] Josefin Lysell
https://www.ncbi.nlm.nih.gov/pubmed/29292942
66. Am J Med, 131 (10), 1146-1154 Oct 2018 Psoriasis and Psoriatic Spectrum Disease: A Primer for the Primary Care Physician Jawad Bilal, Saad Ullah Malik, Irbaz Bin Riaz, Drew J B Kurtzman
https://www.ncbi.nlm.nih.gov/pubmed/29864415
67. Τher Umsch, 67 (4), 153-65 Apr 2010 [Psoriasis] [Article in German] Alexander A Navarini, Ralph M Trüeb
https://www.ncbi.nlm.nih.gov/pubmed/20336615
68. Int J Dermatol, 57 (10), 1165-1172 Oct 2018 Stress and Psoriasis Laurie Rousset, Bruno Halioua
https://www.ncbi.nlm.nih.gov/pubmed/29729012
69. J Am Acad Dermatol, 80 (5), 1332-1343 May 2019 All-cause and Cause-Specific Mortality in Psoriasis: A Systematic Review and Meta-Analysis Ashar Dhana, Hsi Yen, Hsuan Yen, Eunyoung Cho
https://pubmed.ncbi.nlm.nih.gov/30590074/
70. Indian J Dermatol Venereol Leprol, 82 (5), 489-97 Sep-Oct 2016 Psoriasis and Risk of Incident Atrial Fibrillation: A Systematic Review and Meta-Analysis Patompong Ungprasert, Narat Srivali, Wonngarm Kittanamongkolchai
https://pubmed.ncbi.nlm.nih.gov/27451924
71. Br J Dermatol, 170 (2), 304-14 Feb 2014 Psoriasis and Smoking: A Systematic Review and Meta-Analysis A W Armstrong, C T Harskamp, J S Dhillon, E J Armstrong
https://pubmed.ncbi.nlm.nih.gov/24117435
72. J Am Acad Dermatol, 71 (2), 350-8 Aug 2014 Diet and Psoriasis, Part II: Celiac Disease and Role of a Gluten-Free Diet Bhavnit K Bhatia, Jillian W Millsop, Maya Debbaneh, John Koo, Eleni Linos, Wilson Liao
https://pubmed.ncbi.nlm.nih.gov/24780176
http://europepmc.org/article/MED/24780176
73. Immunol Res, 67 (1), 134-141 Feb 2019 The Coexistence of Pemphigus and Psoriasis: A Systematic Review and Meta-Analysis Khalaf Kridin, Mouhammad Kridin, Guy Shalom, Arnon D Cohen
https://pubmed.ncbi.nlm.nih.gov/30338449
74. Australas J Dermatol, 60 (1), 23-28 Feb 2019 Association Between Bullous Pemphigoid and Psoriasis: Systematic Review and Meta-Analysis of Case-Control Studies Kevin Phan, Sourabh Goyal, Dedee F Murrell
https://pubmed.ncbi.nlm.nih.gov/30141189
75. Int Urol Nephrol, 50 (7), 1277-1283 Jul 2018 Psoriasis and Risk of Incident Chronic Kidney Disease and End-Stage Renal Disease: A Systematic Review and Meta-Analysis Patompong Ungprasert, Sukit Raksasuk
https://pubmed.ncbi.nlm.nih.gov/29644523/
76. Indian J Dermatol, 61 (2), 152-6 Mar-Apr 2016 Risk of Parkinson's Disease Among Patients With Psoriasis: A Systematic Review and Meta-analysis Patompong Ungprasert, Narat Srivali, Wonngarm Kittanamongkolchai
https://pubmed.ncbi.nlm.nih.gov/27057013
77. Zhonghua Nan Ke Xue, 23 (3), 256-261 Mar 2017 [Correlation of Psoriasis With Erectile Dysfunction: A Meta-Analysis] [Article in Chinese] Fan-Bo Zhang, Bang-Cai Wu, Li-Bo Xie, Rui Jiang
https://pubmed.ncbi.nlm.nih.gov/29706048
78. QJM, 107 (10), 793-7 Oct 2014 Psoriasis and Risk of Venous Thromboembolism: A Systematic Review and Meta-Analysis Patompong Ungprasert, Anawin Sanguankeo, Sikarin Upala, Promporn Suksaranjit
https://pubmed.ncbi.nlm.nih.gov/24713224/
79. J Dermatolog Treat, 27 (4), 316-21 Aug 2016 Association Between Psoriasis and Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis Patompong Ungprasert, Narat Srivali, Charat Thongprayoon
https://pubmed.ncbi.nlm.nih.gov/26458363
80. J Dermatolog Treat, 28 (5), 406-410 Aug 2017 Psoriasis Increases Risk of New-Onset Atrial Fibrillation: A Systematic Review and Meta-Analysis of Prospective Observational Studies Sikarin Upala, Afeefa Shahnawaz, Anawin Sanguankeo
https://pubmed.ncbi.nlm.nih.gov/27794626
81. Indian J Dermatol, 63 (3), 193-200 May-Jun 2018 Association Between Psoriasis and Helicobacter pylori Infection: A Systematic Review and Meta-analysis Wai Chung Yong, Sikarin Upala, Anawin Sanguankeo
https://pubmed.ncbi.nlm.nih.gov/29937554
82. Medicina (Kaunas), 55 (10) 2019 Sep 26 Helicobacter pylori Infection and Psoriasis: A Systematic Review and Meta-Analysis Mingyang Yu, Rongguang Zhang, Peng Ni, Shuaiyin Chen, Guangcai Duan
https://pubmed.ncbi.nlm.nih.gov/31561576
83. J Invest Dermatol, 138 (1), 38-45 Jan 2018 Efficacy of Systemic Treatments of Psoriasis on Pruritus: A Systemic Literature Review and Meta-Analysis Chloé Théréné, Emilie Brenaut, Thomas Barnetche, Laurent Misery
https://pubmed.ncbi.nlm.nih.gov/28887107
84. J Eur Acad Dermatol Venereol, 27 Suppl 3, 2-11 Aug 2013 Psoriasis, Cardiovascular Events, Cancer Risk and Alcohol Use: Evidence-Based Recommendations Based on Systematic Review and Expert Opinion M-A Richard, T Barnetche, C Horreau, E Brenaut, C Pouplard, S Aractingi, F Aubin, B Cribier, P Joly, D Jullien, M Le Maître, L Misery, J-P Ortonne, C Paul
https://pubmed.ncbi.nlm.nih.gov/23845148/
85. Australas J Dermatol, 45 (3), 155-9; quiz 160-1 Aug 2004 Psychiatric Morbidity in Psoriasis: A Review Paul A J Russo, Ralf Ilchef, Alan J Cooper
https://pubmed.ncbi.nlm.nih.gov/15250891
86. Fleming P, Kraft J, Gulliver WP, Lynde C. The Relationship of Obesity With the Severity of Psoriasis: A Systematic Review. J Cutan Med Surg. 2015 Sep-Oct;19(5):450-6. doi: 10.1177/1203475415586332. Epub 2015 May 7. PMID: 26271963.
https://pubmed.ncbi.nlm.nih.gov/26271963/
87. Budu-Aggrey A, Brumpton B, Tyrrell J, Watkins S, Modalsli EH, Celis-Morales C, Ferguson LD, Vie GÅ, Palmer T, Fritsche LG, Løset M, Nielsen JB, Zhou W, Tsoi LC, Wood AR, Jones SE, Beaumont R, Saunes M, Romundstad PR, Siebert S, McInnes IB, Elder JT, Davey Smith G, Frayling TM, Åsvold BO, Brown SJ, Sattar N, Paternoster L. Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study. PLoS Med. 2019 Jan 31;16(1):e1002739. doi: 10.1371/journal.pmed.1002739. PMID: 30703100; PMCID: PMC6354959.
https://pubmed.ncbi.nlm.nih.gov/30703100/
88. Guo Z, Yang Y, Liao Y, Shi Y, Zhang LJ. Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity. JID Innov. 2021 Oct 13;2(1):100064. doi: 10.1016/j.xjidi.2021.100064. PMID: 35024685; PMCID: PMC8659781.
https://pubmed.ncbi.nlm.nih.gov/35024685/
89. Mendes LC. Effective fuling (Poria Cocos) for the treatment of obesity? Int J Complement Alt Med. 2018;11(6):380-385. DOI: 10.15406/ijcam.2018.11.00430
https://medcraveonline.com/IJCAM/effective-fuling-poria-cocos-for-the-treatment-of-obesity.html
https://www.researchgate.net/publication/329950997_Effective_fuling_Poria_Cocos_for_the_treatment_of_obesity
90. Weng SW, Chen BC, Wang YC, Liu CK, Sun MF, Chang CM, Lin JG, Yen HR. Traditional Chinese Medicine Use among Patients with Psoriasis in Taiwan: A Nationwide Population-Based Study. Evid Based Complement Alternat Med. 2016;2016:3164105. doi: 10.1155/2016/3164105. Epub 2016 Oct 16. PMID: 27822287; PMCID: PMC5086381.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086381/
91. Su, Y., Qin, W., Wu, L. et al. A review of Chinese medicine for the treatment of psoriasis: principles, methods and analysis. Chin Med 16, 138 (2021). https://doi.org/10.1186/s13020-021-00550-y
https://cmjournal.biomedcentral.com/articles/10.1186/s13020-021-00550-y
92. Sung YF, Yin JH, Lee KH, Tsai CL, Lin YK, Chen SY, Chung CH, Chien WC, Lee JT, Chou CH. Increased risk of sleep-related movement disorder in patients with Helicobacter pylori infection: A nationwide population-based study. Front Neurol. 2022 Oct 10;13:953821. doi: 10.3389/fneur.2022.953821. PMID: 36299273; PMCID: PMC9589275.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589275/
93. Wei BR, Zhao YJ, Cheng YF, Huang C, Zhang F. Helicobacter pylori infection and Parkinson's Disease: etiology, pathogenesis and levodopa bioavailability. Immun Ageing. 2024 Jan 2;21(1):1. doi: 10.1186/s12979-023-00404-1. PMID: 38166953; PMCID: PMC10759355.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10759355/
94. Rothenbacher D, Bode G, Peschke F, Berg G, Adler G, Brenner H. Active infection with Helicobacter pylori in an asymptomatic population of middle aged to elderly people. Epidemiol Infect. 1998 Jun;120(3):297-303. doi: 10.1017/s0950268898008644. PMID: 9692608; PMCID: PMC2809407.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809407/
95. Graham DY, Malaty HM, Evans DG, Evans DJ Jr, Klein PD, Adam E. Epidemiology of Helicobacter pylori in an asymptomatic population in the United States. Effect of age, race, and socioeconomic status. Gastroenterology. 1991 Jun;100(6):1495-501. doi: 10.1016/0016-5085(91)90644-z. PMID: 2019355.
https://pubmed.ncbi.nlm.nih.gov/2019355/
96. Epidemiology of, and risk factors for, Helicobacter pylori infection among 3194 asymptomatic subjects in 17 populations. The EUROGAST Study Group. Gut. 1993 Dec;34(12):1672-6. doi: 10.1136/gut.34.12.1672. PMID: 8282253; PMCID: PMC1374460.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1374460/
97. Oludemi Taofiq, Sandrina A. Heleno, Ricardo C. Calhelha, Maria José Alves, Lillian Barros, Ana M. González-Paramás, Maria F. Barreiro, Isabel C.F.R. Ferreira, The potential of Ganoderma lucidum extracts as bioactive ingredients in topical formulations, beyond its nutritional benefits, Food and Chemical Toxicology, Volume 108, Part A, 2017, Pages 139-147, ISSN 0278-6915, https://doi.org/10.1016/j.fct.2017.07.051.
https://www.sciencedirect.com/science/article/abs/pii/S0278691517304337
Α1. Angelini, Paola & Girometta, Carolina & Venanzoni, Roberto & Bertuzzi, Gianluigi. (2022). Anti-Aging Properties of Medicinal Mushrooms in Systemic Aesthetic Medicine. 10.1007/978-981-16-6257-7_7.
https://www.researchgate.net/publication/359317471_Anti-Aging_Properties_of_Medicinal_Mushrooms_in_Systemic_Aesthetic_Medicine
Α2. Kumar, Nanjangud & Quispe, Cristina & Herrera, Jesús & Herrera Belén, Lisandra & Loren Reyes, Pía & Salazar, Luis & Silva, Victor & Orhan, Ilkay & Senol Deniz, Fatma & Nemli, Elifsu & Capanoglu, Esra & Olatunde, Ahmed & Silva, Nathalia & Živković, Jelena & Shorog, Eman & Calina, Daniela & Sharifi-Rad, Javad. (2023). Potential of Mushrooms Bioactive for the Treatment of Skin Diseases and Disorders. Journal of Food Biochemistry. 2023. 1-26. 10.1155/2023/5915769.
https://www.researchgate.net/publication/376450794_Potential_of_Mushrooms_Bioactive_for_the_Treatment_of_Skin_Diseases_and_Disorders
Α3. Fordjour E, Manful CF, Javed R, Galagedara LW, Cuss CW, Cheema M, Thomas R. Chaga mushroom: a super-fungus with countless facets and untapped potential. Front Pharmacol. 2023 Dec 5;14:1273786. doi: 10.3389/fphar.2023.1273786. PMID: 38116085; PMCID: PMC10728660.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10728660/
Α4. Burlec, A.F.; Hăncianu, M.; Ivănescu, B.; Macovei, I.; Corciovă, A. Exploring the Therapeutic Potential of Natural Compounds in Psoriasis and Their Inclusion in Nanotechnological Systems. Antioxidants 2024, 13, 912. https://doi.org/10.3390/antiox13080912
https://www.mdpi.com/2076-3921/13/8/912
Α5. personal care, skin diseases Psoriasis – Plant-based Approach to Strengthen the Skin’s Immune System S. Hettwer, E. Besic Gyenge, B. Suter, B. Obermayer
https://www.rahn-group.com/en/rahn/download-document/845ab00f-9b60-4457-8f65-4162f5f81add/pd_literature_liftonin-qi_techpaper_sofw_2206_enp001621675.pdf
Α6. What are the benefits of lion’s mane mushrooms? Medically reviewed by Kim Rose-Francis RDN, CDCES, LD, Nutrition — Written by Jayne Leonard — Updated on December 10, 2024
https://www.medicalnewstoday.com/articles/323400
Αϋπνία
1. Karna B, Sankari A, Tatikonda G. Sleep Disorder. [Updated 2023 Jun 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK560720/
https://www.ncbi.nlm.nih.gov/books/NBK560720/
2. Jaquelini Betta Canever, Gabriela Zurman, Felipe Vogel, Daiana Vieira Sutil, Juliano Bergamaschine Mata Diz, Ana Lúcia Danielewicz, Bruno de Souza Moreira, Helena Iturvides Cimarosti, Núbia Carelli Pereira de Avelar, Worldwide prevalence of sleep problems in community-dwelling older adults: A systematic review and meta-analysis, Sleep Medicine, Volume 119, 2024, Pages 118-134, ISSN 1389-9457, https://doi.org/10.1016/j.sleep.2024.03.040.
https://www.sciencedirect.com/science/article/abs/pii/S1389945724001448
3. Amiri S, Behnezhad S. Smoking and risk of sleep-related issues: a systematic review and meta-analysis of prospective studies. Can J Public Health. 2020 Oct;111(5):775-786. doi: 10.17269/s41997-020-00308-3. Epub 2020 Mar 17. PMID: 32185746; PMCID: PMC7501367.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7501367/
4. Vernia F, Di Ruscio M, Ciccone A, Viscido A, Frieri G, Stefanelli G, Latella G. Sleep disorders related to nutrition and digestive diseases: a neglected clinical condition. Int J Med Sci. 2021 Jan 1;18(3):593-603. doi: 10.7150/ijms.45512. PMID: 33437194; PMCID: PMC7797530.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7797530/
5. Zhao M, Tuo H, Wang S, Zhao L. The Effects of Dietary Nutrition on Sleep and Sleep Disorders. Mediators Inflamm. 2020 Jun 25;2020:3142874. doi: 10.1155/2020/3142874. PMID: 32684833; PMCID: PMC7334763.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7334763/
6. Exploring the Uses of the Top Medicinal Mushrooms, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Tarikh Input: 22/02/2023 | Kemaskini: 04/04/2023 | aslamiah
https://sgs.upm.edu.my/artikel/exploring_the_uses_of_the_top_medicinal_mushrooms-71534
7. Jia L-F, Chen P, Qu G-D, et al. A comprehensive review of the sedative-hypnotic mechanisms of edible fungi. Food & Medicine Homology, 2025, https://doi.org/10.26599/FMH.2025.9420049
https://www.sciopen.com/article/10.26599/FMH.2025.9420049
8. Wei Chen, Jun-Wen Yu, Yu-Yi Deng, Lut Yi Wong, Chen Wang, Yu-Ling Liang, Yuk-Tung Leung, Jia-Yi Tian, Ying Wu, Kelvin Sze-Yin Leung, Jinhui Hu, Wen-Hua Chen, Xiaobing Dou, Xiu-Qiong Fu, Ying-Jie Chen, Zhi-Ling Yu, Identification of sedative-hypnotic compounds shared by five medicinal Polyporales mushrooms using UPLC-Q-TOF-MS/MS-based untargeted metabolomics, Phytomedicine, Volume 128, 2024, 155355, ISSN 0944-7113, https://doi.org/10.1016/j.phymed.2024.155355.
https://www.sciencedirect.com/science/article/abs/pii/S0944711324000205
9. Tselepis, George & Palamiotis, Ioannis & Georgiou, Sofia. (2023). Homeostasis of Circadian Rhythm and Therapeutic Approaches to Manage its Related-Disorders: The Case of Medicinal Mushrooms Rich in Melatonin. Med Discoveries. 2. 10.52768/2993-1142/1075.
https://www.researchgate.net/publication/375439212_Homeostasis_of_Circadian_Rhythm_and_Therapeutic_Approaches_to_Manage_its_Related-Disorders_The_Case_of_Medicinal_Mushrooms_Rich_in_Melatonin
10. Lu J, Su M, Zhou X, Li D, Niu X, Wang Y. Research Progress of Bioactive Components in Sanghuangporus spp. Molecules. 2024 Mar 7;29(6):1195. doi: 10.3390/molecules29061195. PMID: 38542832; PMCID: PMC10976032.
https://pubmed.ncbi.nlm.nih.gov/38542832/
11. Yao L, Lv J, Duan C, An X, Zhang C, Li D, Li C, Liu S. Armillaria mellea fermentation liquor ameliorates p-chlorophenylalanine-induced insomnia associated with the modulation of serotonergic system and gut microbiota in rats. J Food Biochem. 2022 Feb;46(2):e14075. doi: 10.1111/jfbc.14075. Epub 2022 Jan 5. PMID: 34984694.
https://pubmed.ncbi.nlm.nih.gov/34984694/
12. Sharma H, Sharma N, An SSA. Unique Bioactives from Zombie Fungus (Cordyceps) as Promising Multitargeted Neuroprotective Agents. Nutrients. 2023 Dec 27;16(1):102. doi: 10.3390/nu16010102. PMID: 38201932; PMCID: PMC10780653.
https://pubmed.ncbi.nlm.nih.gov/38201932/
13. Tan YF, Mo JS, Wang YK, Zhang W, Jiang YP, Xu KP, Tan GS, Liu S, Li J, Wang WX. The ethnopharmacology, phytochemistry and pharmacology of the genus Hericium. J Ethnopharmacol. 2024 Jan 30;319(Pt 3):117353. doi: 10.1016/j.jep.2023.117353. Epub 2023 Oct 29. PMID: 37907145.
https://pubmed.ncbi.nlm.nih.gov/37907145/
14. Published April 20, 2009 COMPLEMENTARY and ALTERNATIVE MEDICINE Adaptogenic or Medicinal Mushrooms M. Saljoughian, PharmD, PhD
https://www.uspharmacist.com/article/adaptogenic-or-medicinal-mushrooms
15. Yao, C., Wang, Z., Jiang, H. et al. Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice. Sci Rep 11, 13660 (2021). https://doi.org/10.1038/s41598-021-92913-6
https://www.nature.com/articles/s41598-021-92913-6
16. Batra P, Sharma AK, Khajuria R. Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. Int J Med Mushrooms. 2013;15(2):127-43. doi: 10.1615/intjmedmushr.v15.i2.20. PMID: 23557365.
https://pubmed.ncbi.nlm.nih.gov/23557365/
17. Lee KH, Morris-Natschke SL, Yang X, Huang R, Zhou T, Wu SF, Shi Q, Itokawa H. Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine. J Tradit Complement Med. 2012 Apr;2(2):84-95. PMID: 24716120; PMCID: PMC3942920.
https://core.ac.uk/download/pdf/82062841.pdf
18. Reishi Cultivation The mushroom of immortality, Michael den Herder, European Forest Institute, [email protected] April 2022
https://efi.int/sites/default/files/files/knowledge/projects/EFI_Reishi_Cultivation_EN.pdf
19. Sanodiya BS, Thakur GS, Baghel RK, Prasad GB, Bisen PS. Ganoderma lucidum: a potent pharmacological macrofungus. Curr Pharm Biotechnol. 2009 Dec;10(8):717-42. doi: 10.2174/138920109789978757. PMID: 19939212.
https://pubmed.ncbi.nlm.nih.gov/19939212/
20. Yao C, Wang Z, Jiang H, Yan R, Huang Q, Wang Y, Xie H, Zou Y, Yu Y, Lv L. Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice. Sci Rep. 2021 Jul 1;11(1):13660. doi: 10.1038/s41598-021-92913-6. PMID: 34211003; PMCID: PMC8249598.
https://pubmed.ncbi.nlm.nih.gov/34211003/
21. Xiang-Yu Cui, Su-Ying Cui, Juan Zhang, Zi-Jun Wang, Bin Yu, Zhao-Fu Sheng, Xue-Qiong Zhang, Yong-He Zhang, Extract of Ganoderma lucidum prolongs sleep time in rats, Journal of Ethnopharmacology, Volume 139, Issue 3, 2012, Pages 796-800, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2011.12.020.
https://www.sciencedirect.com/science/article/abs/pii/S0378874111008981
Α1. Mai E, Buysse DJ. Insomnia: Prevalence, Impact, Pathogenesis, Differential Diagnosis, and Evaluation. Sleep Med Clin. 2008;3(2):167-174. doi: 10.1016/j.jsmc.2008.02.001. PMID: 19122760; PMCID: PMC2504337.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504337/
Α2. Sleep Disorders, USA National Library of Medicine
https://medlineplus.gov/sleepdisorders.html
Α3. Insomnia, Department of Neurology Sleep Medicine Center, Washington University School of Medicine
https://sleep.wustl.edu/sleep-disorders-and-treatments/sleep-disorders/insomnia/
Α4. Insomnia: What You Need to Know as You Age, Rachel Salas, M.D., Johns Hopkins University
https://www.hopkinsmedicine.org/health/conditions-and-diseases/insomnia-what-you-need-to-know-as-you-age
Α5. American Psychiatric Association, What are Sleep Disorders?, Felix Torres, MD, MBA, DFAPA August 2020
https://www.psychiatry.org/patients-families/sleep-disorders/what-are-sleep-disorders
Α6. Insomnia, 15 Dec 2023, BMJ Publishing Group
https://bestpractice.bmj.com/topics/en-gb/227
Α7. Bollu PC, Kaur H. Sleep Medicine: Insomnia and Sleep. Mo Med. 2019 Jan-Feb;116(1):68-75. PMID: 30862990; PMCID: PMC6390785.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390785/
Α8. Riedel BW, Lichstein KL. Insomnia and daytime functioning. Sleep Med Rev. 2000 Jun;4(3):277-298. doi: 10.1053/smrv.1999.0074. PMID: 12531170.
https://pubmed.ncbi.nlm.nih.gov/12531170/
Α9. A Vicious Cycle: Insomnia, Anxiety, and Depression, Duke University Health System
https://www.dukehealth.org/blog/vicious-cycle-insomnia-anxiety-and-depression
Α10. Franzen PL, Buysse DJ. Sleep disturbances and depression: risk relationships for subsequent depression and therapeutic implications. Dialogues Clin Neurosci. 2008;10(4):473-81. doi: 10.31887/DCNS.2008.10.4/plfranzen. PMID: 19170404; PMCID: PMC3108260.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108260/
Α11. Li, L., Wu, C., Gan, Y. et al. Insomnia and the risk of depression: a meta-analysis of prospective cohort studies. BMC Psychiatry 16, 375 (2016). https://doi.org/10.1186/s12888-016-1075-3
https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-016-1075-3
Α12. April 27, 2021 Lack of sleep in middle age may increase dementia risk
https://www.nih.gov/news-events/nih-research-matters/lack-sleep-middle-age-may-increase-dementia-risk
Α13. Wong R, Lovier MA. Sleep Disturbances and Dementia Risk in Older Adults: Findings From 10 Years of National U.S. Prospective Data. Am J Prev Med. 2023 Jun;64(6):781-787. doi: 10.1016/j.amepre.2023.01.008. Epub 2023 Jan 26. PMID: 36707315.
https://www.ajpmonline.org/article/S0749-3797(23)00009-0/fulltext
Α14. Hung CM, Li YC, Chen HJ, Lu K, Liang CL, Liliang PC, Tsai YD, Wang KW. Risk of dementia in patients with primary insomnia: a nationwide population-based case-control study. BMC Psychiatry. 2018 Feb 7;18(1):38. doi: 10.1186/s12888-018-1623-0. PMID: 29415688; PMCID: PMC5804010.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804010/
Α15. Sadeghmousavi, S., Eskian, M., Rahmani, F. et al. The effect of insomnia on development of Alzheimer’s disease. J Neuroinflammation 17, 289 (2020). https://doi.org/10.1186/s12974-020-01960-9
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-020-01960-9
Α16. Osorio RS, Pirraglia E, Agüera-Ortiz LF, During EH, Sacks H, Ayappa I, Walsleben J, Mooney A, Hussain A, Glodzik L, Frangione B, Martínez-Martín P, de Leon MJ. Greater risk of Alzheimer's disease in older adults with insomnia. J Am Geriatr Soc. 2011 Mar;59(3):559-62. doi: 10.1111/j.1532-5415.2010.03288.x. PMID: 21391952; PMCID: PMC3378676.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378676/
Α17. Lv Y-N, Cui Y, Zhang B and Huang S-M (2022) Sleep deficiency promotes Alzheimer's disease development and progression. Front. Neurol. 13:1053942. doi: 10.3389/fneur.2022.1053942
https://www.frontiersin.org/articles/10.3389/fneur.2022.1053942/full
Α18. Javaheri S, Redline S. Insomnia and Risk of Cardiovascular Disease. Chest. 2017 Aug;152(2):435-444. doi: 10.1016/j.chest.2017.01.026. Epub 2017 Jan 30. PMID: 28153671; PMCID: PMC5577359.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577359/
Α19. How Does Sleep Affect Your Heart Health?, January 4, 2021, National Center for Chronic Disease Prevention and Health Promotion , Division for Heart Disease and Stroke Prevention
https://www.cdc.gov/bloodpressure/sleep.htm
Α20. Insomnia Tied to Greater Risk of Heart Attack, Especially in Women, Nicole Napoli, American College of Cardiology Foundation
https://www.acc.org/About-ACC/Press-Releases/2023/02/23/18/23/Insomnia-Tied-to-Greater-Risk-of-Heart-Attack-Especially-in-Women
Α20. Morin CM, Altena E, Ivers H, Mérette C, LeBlanc M, Savard J, Philip P. Insomnia, hypnotic use, and road collisions: a population-based, 5-year cohort study. Sleep. 2020 Aug 12;43(8):zsaa032. doi: 10.1093/sleep/zsaa032. PMID: 32112107; PMCID: PMC7420516.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7420516/
Α21. Garbarino S, Magnavita N, Guglielmi O, Maestri M, Dini G, Bersi FM, Toletone A, Chiorri C, Durando P. Insomnia is associated with road accidents. Further evidence from a study on truck drivers. PLoS One. 2017 Oct 31;12(10):e0187256. doi: 10.1371/journal.pone.0187256. PMID: 29088276; PMCID: PMC5663450.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663450/
Α22. Insomnia increases risk of motor vehicle deaths, other fatal injuries, Lynn Celmer, American Academy of Sleep Medicine
https://aasm.org/insomnia-increases-risk-of-motor-vehicle-deaths-other-fatal-injuries/
Α23. Léger D, Bayon V, Ohayon MM, Philip P, Ement P, Metlaine A, Chennaoui M, Faraut B. Insomnia and accidents: cross-sectional study (EQUINOX) on sleep-related home, work and car accidents in 5293 subjects with insomnia from 10 countries. J Sleep Res. 2014 Apr;23(2):143-52. doi: 10.1111/jsr.12104. Epub 2013 Nov 15. PMID: 24237855.
https://onlinelibrary.wiley.com/doi/10.1111/jsr.12104
Α24. Qiu Y, Mao ZJ, Ruan YP, Zhang X. Exploration of the anti-insomnia mechanism of Ganoderma by central-peripheral multi-level interaction network analysis. BMC Microbiol. 2021 Oct 29;21(1):296. doi: 10.1186/s12866-021-02361-5. PMID: 34715778; PMCID: PMC8555286.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555286/
Α25. Ekiz E, Oz E, Abd El-Aty AM, Proestos C, Brennan C, Zeng M, Tomasevic I, Elobeid T, Çadırcı K, Bayrak M, Oz F. Exploring the Potential Medicinal Benefits of Ganoderma lucidum: From Metabolic Disorders to Coronavirus Infections. Foods. 2023 Apr 3;12(7):1512. doi: 10.3390/foods12071512. PMID: 37048331; PMCID: PMC10094145.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094145/
Α26. Cui X, Zhang Y. Neuropharmacological Effect and Clinical Applications of Ganoderma (Lingzhi). Adv Exp Med Biol. 2019;1182:143-157. doi: 10.1007/978-981-32-9421-9_5. PMID: 31777017.
https://pubmed.ncbi.nlm.nih.gov/31777017/
Α27. Qiu Y, Mao ZJ, Ruan YP, Zhang X. Exploration of the anti-insomnia mechanism of Ganoderma by central-peripheral multi-level interaction network analysis. BMC Microbiol. 2021 Oct 29;21(1):296. doi: 10.1186/s12866-021-02361-5. PMID: 34715778; PMCID: PMC8555286.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555286/
Α28. Evid Based Complement Alternat Med, 2019, 7861297 2019 Apr 18 eCollection 2019 Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? Luisella Vigna, Federica Morelli, Gianna M Agnelli, Filomena Napolitano, Daniela Ratto, Alessandra Occhinegro, Carmine Di Iorio, Elena Savino, Carolina Girometta, Federico Brandalise, Paola Rossi
https://europepmc.org/article/MED/31118969
Α29. Brandalise F, Roda E, Ratto D, Goppa L, Gargano ML, Cirlincione F, Priori EC, Venuti MT, Pastorelli E, Savino E, Rossi P. Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline? J Fungi (Basel). 2023 May 10;9(5):551. doi: 10.3390/jof9050551. PMID: 37233262; PMCID: PMC10218917.
https://pubmed.ncbi.nlm.nih.gov/37233262/
Α30. Okamura, Hisayoshi & Anno, Nobuko & Tsuda, Akira & Inokuchi, Takahiro & Uchimura, Naohisa & Inanaga, Kazutoyo. (2015). The effects of Hericium erinaceus (Amyloban® 3399) on sleep quality and subjective well-being among female undergraduate students: A pilot study. Personalized Medicine Universe. 4. 10.1016/j.pmu.2015.03.006.
https://www.researchgate.net/publication/276152143_The_effects_of_Hericium_erinaceus_AmylobanR_3399_on_sleep_quality_and_subjective_well-being_among_female_undergraduate_students_A_pilot_study
Α31. Wei C, Wang H, Sun X, Bai Z, Wang J, Bai G, Yao Q, Xu Y, Zhang L. Pharmacological profiles and therapeutic applications of pachymic acid (Review). Exp Ther Med. 2022 Jul 1;24(3):547. doi: 10.3892/etm.2022.11484. PMID: 35978941; PMCID: PMC9366251.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366251/
Α32. Kim H, Choi H, Park BG, Ju HJ, Kim YI. Efficacy of Poria Cocos Extract on Sleep Quality Enhancement: A Clinical Perspective with Implications for Functional Foods. Nutrients. 2023 Oct 1;15(19):4242. doi: 10.3390/nu15194242. PMID: 37836526; PMCID: PMC10574255.
https://pubmed.ncbi.nlm.nih.gov/37836526/
A33. Hu Z, Oh S, Ha TW, Hong JT, Oh KW. Sleep-Aids Derived from Natural Products. Biomol Ther (Seoul). 2018 Jul 1;26(4):343-349. doi: 10.4062/biomolther.2018.099. PMID: 29929351; PMCID: PMC6029681.
https://pubmed.ncbi.nlm.nih.gov/29929351/
A34. Verma K, Singh D, Srivastava A. The Impact of Complementary and Alternative Medicine on Insomnia: A Systematic Review. Cureus. 2022 Aug 26;14(8):e28425. doi: 10.7759/cureus.28425. PMID: 36176875; PMCID: PMC9509538.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509538/
A35. 12. Dr Sony Sherpa, The Benefits of Lion’s Mane Mushroom for Sleep Last Updated on March 24, 2023
https://worldmushroomsociety.com/lions-mane-sleep-benefits/
A36. Inanaga, Kazutoyo. “Amycenone, a nootropic found in Hericium erinaceum.” Personalized Medicine Universe 1 (2012): 13-17.
https://www.sciencedirect.com/science/article/abs/pii/S2186495012000089
A37. The Gift of the Night: A Six-Step Program for Better Sleep Paperback – October 3, 2023 by Philip Carr-Gomm
https://books.google.gr/books?id=BUCvEAAAQBAJ&pg=PT60&lpg=PT60&dq=lion%27s+mane+remyelination&source=bl&ots=7sEkQr0NTC&sig=ACfU3U0BuL5Cu656iOUWaEDV4ZtzgVQdhw&hl=el&sa=X&ved=2ahUKEwjK_daviJqGAxXSQPEDHWFgAKw4RhDoAXoECAcQAw#v=onepage&q=lion's%20mane%20remyelination&f=false
https://www.amazon.com/Gift-Night-Six-Step-Program-Better/dp/1644119293
https://philipcarr-gomm.com/
Τεκνοποίηση - Λίμπιντο
1. Sharma M, Leslie SW. Azoospermia. [Updated 2023 Nov 18]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK578191/
2. Cocuzza M, Alvarenga C, Pagani R. The epidemiology and etiology of azoospermia. Clinics (Sao Paulo). 2013;68 Suppl 1(Suppl 1):15-26. doi: 10.6061/clinics/2013(sup01)03. PMID: 23503951; PMCID: PMC3583160.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3583160/
3. Majzoub, A.; Viana, M.C.; Achermann, A.P.P.; Ferreira, I.T.; Laursen, R.J.; Humaidan, P.; Esteves, S.C. Non-Obstructive Azoospermia and Intracytoplasmic Sperm Injection: Unveiling the Chances of Success and Possible Consequences for Offspring. J. Clin. Med. 2024, 13, 4939. https://doi.org/10.3390/jcm13164939
https://www.mdpi.com/2077-0383/13/16/4939
4. Bundhun PK, Janoo G, Bhurtu A, Teeluck AR, Soogund MZS, Pursun M, Huang F. Tobacco smoking and semen quality in infertile males: a systematic review and meta-analysis. BMC Public Health. 2019 Jan 8;19(1):36. doi: 10.1186/s12889-018-6319-3. PMID: 30621647; PMCID: PMC6325781.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6325781/
5. Skoracka K, Eder P, Łykowska-Szuber L, Dobrowolska A, Krela-Kaźmierczak I. Diet and Nutritional Factors in Male (In)fertility-Underestimated Factors. J Clin Med. 2020 May 9;9(5):1400. doi: 10.3390/jcm9051400. PMID: 32397485; PMCID: PMC7291266.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7291266/
539. Leslie SW, Soon-Sutton TL, Khan MAB. Male Infertility. [Updated 2024 Feb 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK562258/
540. Huang, B., Wang, Z., Kong, Y. et al. Global, regional and national burden of male infertility in 204 countries and territories between 1990 and 2019: an analysis of global burden of disease study. BMC Public Health 23, 2195 (2023). https://doi.org/10.1186/s12889-023-16793-3
https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-023-16793-3
541. Shah, Kirati M.; Gamit, Kanan G.; Raval, Manan A.; Vyas, Niraj Y.. Male infertility: A scoping review of prevalence, causes and treatments. Asian Pacific Journal of Reproduction 10(5):p 195-202, October 2021. | DOI: 10.4103/2305-0500.326717
https://journals.lww.com/apjr/fulltext/2021/10050/male_infertility__a_scoping_review_of_prevalence,.1.aspx
542. Agarwal A, Mulgund A, Hamada A, Chyatte MR. A unique view on male infertility around the globe. Reprod Biol Endocrinol. 2015 Apr 26;13:37. doi: 10.1186/s12958-015-0032-1. PMID: 25928197; PMCID: PMC4424520.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4424520/
543. Leslie SW, Soon-Sutton TL, Khan MAB. Male Infertility. 2024 Feb 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 32965929.
https://pubmed.ncbi.nlm.nih.gov/32965929/
544. How common is male infertility, and what are its causes? 11/18/2021, NIH Eunice Kennedy Shriver National Institute of Child Health and Human Development
https://www.nichd.nih.gov/health/topics/menshealth/conditioninfo/infertility
545. Dai JB, Wang ZX, Qiao ZD. The hazardous effects of tobacco smoking on male fertility. Asian J Androl. 2015 Nov-Dec;17(6):954-60. doi: 10.4103/1008-682X.150847. PMID: 25851659; PMCID: PMC4814952.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4814952/
546. Harlev A, Agarwal A, Gunes SO, Shetty A, du Plessis SS. Smoking and Male Infertility: An Evidence-Based Review. World J Mens Health. 2015 Dec;33(3):143-60. doi: 10.5534/wjmh.2015.33.3.143. Epub 2015 Dec 23. PMID: 26770934; PMCID: PMC4709430.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4709430/
547. Liu, Y., Chen, S., Pang, D. et al. Effects of paternal exposure to cigarette smoke on sperm DNA methylation and long-term metabolic syndrome in offspring. Epigenetics & Chromatin 15, 3 (2022). https://doi.org/10.1186/s13072-022-00437-8
https://epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-022-00437-8
548. Kovac JR, Labbate C, Ramasamy R, Tang D, Lipshultz LI. Effects of cigarette smoking on erectile dysfunction. Andrologia. 2015 Dec;47(10):1087-92. doi: 10.1111/and.12393. Epub 2014 Dec 29. PMID: 25557907; PMCID: PMC4485976.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4485976/
549. Skoracka K, Eder P, Łykowska-Szuber L, Dobrowolska A, Krela-Kaźmierczak I. Diet and Nutritional Factors in Male (In)fertility-Underestimated Factors. J Clin Med. 2020 May 9;9(5):1400. doi: 10.3390/jcm9051400. PMID: 32397485; PMCID: PMC7291266.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7291266/
550. Ferramosca A, Zara V. Diet and Male Fertility: The Impact of Nutrients and Antioxidants on Sperm Energetic Metabolism. Int J Mol Sci. 2022 Feb 25;23(5):2542. doi: 10.3390/ijms23052542. PMID: 35269682; PMCID: PMC8910394.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8910394/
551. Pecora, G., Sciarra, F., Gangitano, E. et al. How Food Choices Impact on Male Fertility. Curr Nutr Rep 12, 864–876 (2023). https://doi.org/10.1007/s13668-023-00503-x
https://link.springer.com/article/10.1007/s13668-023-00503-x#citeas
552. Almujaydil, M.S. The Role of Dietary Nutrients in Male Infertility: A Review. Life 2023, 13, 519. https://doi.org/10.3390/life13020519
https://www.mdpi.com/2075-1729/13/2/519
HIV
1. Lu, Da & wu, Hong & Lu, Ting-Ren. (2020). HIV/AIDS treatment, therapeutic strategy break throughs. Hospice & Palliative Medicine International Journal. 4. 10.15406/hpmij.2020.04.00182.
https://www.researchgate.net/publication/339998514_HIVAIDS_Treatment_Therapeutic_Strategy_Breakthrough
2. Olatunji OJ, Tang J, Tola A, Auberon F, Oluwaniyi O, Ouyang Z. The genus Cordyceps: An extensive review of its traditional uses, phytochemistry and pharmacology. Fitoterapia. 2018 Sep;129:293-316. doi: 10.1016/j.fitote.2018.05.010. Epub 2018 May 24. PMID: 29775778.
https://pubmed.ncbi.nlm.nih.gov/29775778/
3. Das SK, Masuda M, Sakurai A, Sakakibara M. Medicinal uses of the mushroom Cordyceps militaris: current state and prospects. Fitoterapia. 2010 Dec;81(8):961-8. doi: 10.1016/j.fitote.2010.07.010. Epub 2010 Jul 19. PMID: 20650308.
https://pubmed.ncbi.nlm.nih.gov/20650308/
4. Bhambri A, Srivastava M, Mahale VG, Mahale S, Karn SK. Mushrooms as Potential Sources of Active Metabolites and Medicines. Front Microbiol. 2022 Apr 26;13:837266. doi: 10.3389/fmicb.2022.837266. PMID: 35558110; PMCID: PMC9090473.
https://pubmed.ncbi.nlm.nih.gov/35558110/
5. Harvanová J, Maľučká LU, Uhrinová A, Vilková M, Vavra M, Pavlík M, Rajtar M, Furmaníková A. NMR and IR analysis of natural substances isolated from Cordyceps medicinal mushrooms. Ceska Slov Farm. 2018 Dec 18;67(5-6):200-204. English. PMID: 30871325.
https://pubmed.ncbi.nlm.nih.gov/30871325/
6. Ryu E, Son M, Lee M, Lee K, Cho JY, Cho S, Lee SK, Lee YM, Cho H, Sung GH, Kang H. Cordycepin is a novel chemical suppressor of Epstein-Barr virus replication. Oncoscience. 2014 Dec 18;1(12):866-881. doi: 10.18632/oncoscience.110. PMID: 25621301; PMCID: PMC4303894.
https://pubmed.ncbi.nlm.nih.gov/25621301/
7. Luo C, Xu X, Wei X, Feng W, Huang H, Liu H, Xu R, Lin J, Han L, Zhang D. Natural medicines for the treatment of fatigue: Bioactive components, pharmacology, and mechanisms. Pharmacol Res. 2019 Oct;148:104409. doi: 10.1016/j.phrs.2019.104409. Epub 2019 Aug 22. PMID: 31446039.
https://pubmed.ncbi.nlm.nih.gov/31446039/
8. Zhu Y, Ma L, Hu Q, Li J, Chen Y, Jia R, Shen S, Zeng Y. [In Vitro Anti-HIV-1 Activity of Cordyceps sinensis Extracts]. Bing Du Xue Bao. 2016 Jul;32(4):417-22. Chinese. PMID: 29979545.
https://pubmed.ncbi.nlm.nih.gov/29979545/
9. Wang SX, Liu Y, Zhang GQ, Zhao S, Xu F, Geng XL, Wang HX. Cordysobin, a novel alkaline serine protease with HIV-1 reverse transcriptase inhibitory activity from the medicinal mushroom Cordyceps sobolifera. J Biosci Bioeng. 2012 Jan;113(1):42-7. doi: 10.1016/j.jbiosc.2011.09.005. Epub 2011 Oct 20. PMID: 22014786.
https://pubmed.ncbi.nlm.nih.gov/22014786/
10. Jiang, Y.; Wong, J.H.; Fu, M.; Ng, T.B.; Liu, Z.K.; Wang, C.R.; Li, N.; Qiao, W.T.; Wen, T.Y.; Liu, F. Isolation of Adenosine, Iso-Sinensetin and Dimethylguanosine with Antioxidant and HIV-1 Protease Inhibiting Activities from Fruiting Bodies of Cordyceps militaris. Phytomedicine 2011, 18, 189–193
https://www.mdpi.com/2673-6918/2/4/32
11. Fu M, Qiao WT, Hou J (2007). Compounds from Cordyceps militaris with anti-HIV activities. Acta Scientiarum Naturalium Universitatis Nankaiensis 40:91-95.
https://journals.sagepub.com/doi/abs/10.1177/0022034511399912
12. Zhang, Yu, Guoying Zhang, and Jianya Ling. 2022. "Medicinal Fungi with Antiviral Effect" Molecules 27, no. 14: 4457. https://doi.org/10.3390/molecules27144457
https://www.mdpi.com/1420-3049/27/14/4457
13. Wong JH, Ng TB, Wang H, Sze SC, Zhang KY, Li Q, Lu X. Cordymin, an antifungal peptide from the medicinal fungus Cordyceps militaris. Phytomedicine. 2011 Mar 15;18(5):387-92. doi: 10.1016/j.phymed.2010.07.010. Epub 2010 Aug 23. PMID: 20739167.
http://higiene.unex.es/bibliogr/Antifung/Wong10P.pdf
14. Wong JH, Wang H, Ng TB. A haemagglutinin from the medicinal fungus Cordyceps militaris. Biosci Rep. 2009 Jun 25;29(5):321-7. doi: 10.1042/BSR20080153. PMID: 19093913.
https://pubmed.ncbi.nlm.nih.gov/19093913/
15. Shahrajabian MH, Sun W. The Importance of Traditional Chinese Medicine in the Intervention and Treatment of HIV while Considering its Safety and Efficacy. Curr HIV Res. 2023;21(6):331-346. doi: 10.2174/011570162X271199231128092621. PMID: 38047360.
https://pubmed.ncbi.nlm.nih.gov/38047360/
16. Lu WB, Wen RX, Guan CF. [A report on 8 seronegative converted HIV/AIDS patients with traditional Chinese medicine]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997 May;17(5):271-3. Chinese. PMID: 9863108.
https://mednexus.org/doi/pdf/10.5555/cmj.0366-6999.108.08.p634.01
https://pubmed.ncbi.nlm.nih.gov/9863108/
17. Samarasinghe K, Y. Waisundara V. Therapeutic Properties and Anti-Lipidemic Activity of Cordyceps sinensis [Internet]. Apolipoproteins, Triglycerides and Cholesterol. IntechOpen; 2020. Available from: http://dx.doi.org/10.5772/intechopen.92616
https://www.intechopen.com/chapters/72232
18. Adotey G, Quarcoo A, Holliday JC, Fofie S, Saaka B. Effect of immunomodulating and antiviral agent of medicinal mushrooms (immune assist 24/7) on CD4+ T-lymphocyte counts of HIV-infected patients. Int J Med Mushrooms. 2011;13(2):109-13. doi: 10.1615/intjmedmushr.v13.i2.20. PMID: 22135886.
https://pubmed.ncbi.nlm.nih.gov/22135886/
https://www.researchgate.net/figure/Results-of-60-Day-Immune-Assist-24-7-Trial-with-8-HIV-Patients-Without-Antiretroviral_tbl1_51848140
19. Textbook of Natural Medicine, 4th Edition Authors : Joseph E. Pizzorno & Michael T. Murray Date of Publication: 12/2012
https://www.eu.elsevierhealth.com/textbook-of-natural-medicine-9781437723335.html?
https://books.google.gr/books?id=e_xEF3gwmmoC&pg=PA846&lpg=PA846&dq=hiv+cordyceps&source=bl&ots=J3Px7lOOxV&sig=ACfU3U0iWteLF8uaQ1xPu-Hyk8cQctC0Qg&hl=el&sa=X&ved=2ahUKEwjtn-H8_u2EAxWISfEDHZISAbY4MhDoAXoECAIQAw#v=onepage&q=hiv%20cordyceps&f=false
20. Walter Ardigò,
α. Βιογραφικό:
https://dottorardigo.it/chi-sono/curriculum/
β. Βιβλίο:
- https://www.amazon.com/Healing-Medicinal-Mushrooms-practical-handbook-ebook/dp/B07B3LL7H5
-https://books.google.gr/books?id=3hMgDgAAQBAJ&pg=PT85&lpg=PT85&dq=hiv+cordyceps&source=bl&ots=CDF4up02do&sig=ACfU3U18GrDEFEujU5IVBraAm6W3xESqqg&hl=el&sa=X&ved=2ahUKEwjtn-H8_u2EAxWISfEDHZISAbY4MhDoAXoECAQQAw#v=onepage&q=hiv%20cordyceps&f=false
21. Seetaha S, Ratanabunyong S, Tabtimmai L, Choowongkomon K, Rattanasrisomporn J, Choengpanya K. Anti-feline immunodeficiency virus reverse transcriptase properties of some medicinal and edible mushrooms. Vet World. 2020 Sep;13(9):1798-1806. doi: 10.14202/vetworld.2020.1798-1806. Epub 2020 Sep 5. PMID: 33132590; PMCID: PMC7566271.
https://pubmed.ncbi.nlm.nih.gov/33132590/
22. Forzan M, Pacini MI, Bonaccini P, Mazzei M. Antiviral effect of a commercially phytotherapeutic compound against feline immunodeficiency virus. Nat Prod Res. 2022 Aug;36(16):4159-4164. doi: 10.1080/14786419.2021.1960329. Epub 2021 Sep 29. PMID: 34586005.
https://pubmed.ncbi.nlm.nih.gov/34586005/
23. Sukati NA, Mndebele SC, Makoa ET, Ramukumba TS, Makoae LN, Seboni NM, Human S, Holzemer WL. HIV/AIDS symptom management in Southern Africa. J Pain Symptom Manage. 2005 Feb;29(2):185-92. doi: 10.1016/j.jpainsymman.2004.05.007. PMID: 15733810.
https://www.jpsmjournal.com/article/S0885-3924(04)00542-1/fulltext
24. Zhang FF, Liu RM. [Pharmacokinetics of ganoderic acids]. Zhongguo Zhong Yao Za Zhi. 2019 Mar;44(5):905-911. Chinese. doi: 10.19540/j.cnki.cjcmm.20181213.002. PMID: 30989848.
https://pubmed.ncbi.nlm.nih.gov/30989848/
25. Wu S, Zhang S, Peng B, et al. Ganoderma lucidum: a comprehensive review of phytochemistry, efficacy, safety and clinical study. Food Science and Human Wellness, 2024, 13(2): 568-596. https://doi.org/10.26599/FSHW.2022.9250051
https://www.sciopen.com/article/10.26599/FSHW.2022.9250051
26. Ahmad MF, Ahmad FA, Khan MI, Alsayegh AA, Wahab S, Alam MI, Ahmed F. Ganoderma lucidum: A potential source to surmount viral infections through β-glucans immunomodulatory and triterpenoids antiviral properties. Int J Biol Macromol. 2021 Sep 30;187:769-779. doi: 10.1016/j.ijbiomac.2021.06.122. Epub 2021 Jun 29. PMID: 34197853.
https://pubmed.ncbi.nlm.nih.gov/34197853/
27. Sanodiya BS, Thakur GS, Baghel RK, Prasad GB, Bisen PS. Ganoderma lucidum: a potent pharmacological macrofungus. Curr Pharm Biotechnol. 2009 Dec;10(8):717-42. doi: 10.2174/138920109789978757. PMID: 19939212.
https://pubmed.ncbi.nlm.nih.gov/19939212/
28. Hsu CL, Yen GC. Ganoderic Acid and Lucidenic Acid (Triterpenoid). Enzymes. 2014;36:33-56. doi: 10.1016/B978-0-12-802215-3.00003-3. PMID: 27102698.
https://pubmed.ncbi.nlm.nih.gov/27102698/
29. Tan Z, Zhao JL, Liu JM, Zhang M, Chen RD, Xie KB, Chen DW, Dai JG. Lanostane triterpenoids and ergostane-type steroids from the cultured mycelia of Ganoderma capense. J Asian Nat Prod Res. 2018 Sep;20(9):844-851. doi: 10.1080/10286020.2017.1399879. Epub 2017 Nov 9. PMID: 29119831.
https://pubmed.ncbi.nlm.nih.gov/29119831/
30. Cör Andrejč D, Knez Ž and Knez Marevci M (2022) Antioxidant, antibacterial, antitumor, antifungal, antiviral, anti-inflammatory, and nevro-protective activity of Ganoderma lucidum: An overview. Front. Pharmacol. 13:934982. doi: 10.3389/fphar.2022.934982
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.934982/full
31. Pharm Sci Asia ; 40(3), Research and Development of Ganoderma lucidum Cultivated in Thailand P. Poomsing, K. Pattanapanyasat, P. Wongsinkongman, and N. Soonthornchareonnon*
https://pharmacy.mahidol.ac.th/journal/_files/2013-40-3_01-07.pdf
32. Meng L, Bai X, Zhang S, Zhang M, Zhou S, Mukhtar I, Wang L, Li Z, Wang W. Enhanced Ganoderic Acids Accumulation and Transcriptional Responses of Biosynthetic Genes in Ganoderma lucidum Fruiting Bodies by Elicitation Supplementation. Int J Mol Sci. 2019 Jun 10;20(11):2830. doi: 10.3390/ijms20112830. PMID: 31185659; PMCID: PMC6600565.
https://pubmed.ncbi.nlm.nih.gov/31185659/
33. Tan Z, Zhao J, Liu J, Zhang M, Chen R, Xie K, Dai J. Data on eleven sesquiterpenoids from the cultured mycelia of Ganoderma capense. Data Brief. 2017 Apr 19;12:361-363. doi: 10.1016/j.dib.2017.04.012. PMID: 28491940; PMCID: PMC5413196.
https://pubmed.ncbi.nlm.nih.gov/28491940/
34. Maria S. Serna-Arbeláez, Laura Florez-Sampedro, Lina P. Orozco, Katherin Ramírez, Elkin Galeano, Wildeman Zapata, "Natural Products with Inhibitory Activity against Human Immunodeficiency Virus Type 1", Advances in Virology, vol. 2021, Article ID 5552088, 22 pages, 2021. https://doi.org/10.1155/2021/5552088
https://www.hindawi.com/journals/av/2021/5552088/
35. F. Hümeyra ZENGİNa, Nevin ŞANLIERb, .: REVIEW Connection of Ganoderma Lucidum with Health, J Tradit Complem Med. 2020;3(1):84-98 doi: 10.5336/jtracom.2019-71988
https://www.turkiyeklinikleri.com/article/en-connection-of-ganoderma-lucidum-with-health-87626.html
36. Cancemi, G.; Caserta, S.; Gangemi, S.; Pioggia, G.; Allegra, A. Exploring the Therapeutic Potential of Ganoderma lucidum in Cancer. J. Clin. Med. 2024, 13, 1153. https://doi.org/10.3390/jcm13041153
https://www.mdpi.com/2077-0383/13/4/1153
37. Luo Q, Li N and Xu J-W (2022) A methyltransferase LaeA regulates ganoderic acid biosynthesis in Ganoderma lingzhi. Front. Microbiol. 13:1025983. doi: 10.3389/fmicb.2022.1025983
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.1025983/full
38. Sanodiya S. Bhagwan, Thakur S. Gulab, Baghel K. Rakesh, Prasad B.K.S. G. and Bisen S. P., Ganoderma lucidum: A Potent Pharmacological Macrofungus, Current Pharmaceutical Biotechnology 2009; 10 (8) . https://dx.doi.org/10.2174/138920109789978757
https://www.eurekaselect.com/article/15593
39. Bharadwaj, S., Lee, K.E., Dwivedi, V.D. et al. Discovery of Ganoderma lucidum triterpenoids as potential inhibitors against Dengue virus NS2B-NS3 protease. Sci Rep 9, 19059 (2019). https://doi.org/10.1038/s41598-019-55723-5
https://www.nature.com/articles/s41598-019-55723-5
40. Herbal carbohydrates in healthcare Barbara Sawicka, ... Bernadetta Bienia, in Herbal Biomolecules in Healthcare Applications, 2022
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/lingzhi-mushroom
41. Chen, S. (2020) The Pharmacological Effects of Triterpenoids from Ganoderma lucidum and the Regulation of Its Biosynthesis. Advances in Biological Chemistry, 10, 55-65. doi: 10.4236/abc.2020.102005.
https://www.scirp.org/journal/paperinformation?paperid=99724
42. Cheng PG, Teoh TC, Rizman-Idid M. Chemical Compounds and Computational Prediction of Their Inhibitory Effects on the HIV-1 gp120 Receptor by Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), with Antler-Like Morphology of Fruiting Bodies. Int J Med Mushrooms. 2021;23(7):63-77. doi: 10.1615/IntJMedMushrooms.2021038682. PMID: 34375519.
https://pubmed.ncbi.nlm.nih.gov/34375519/
43. Wang L, Li JQ, Zhang J, Li ZM, Liu HG, Wang YZ. Traditional uses, chemical components and pharmacological activities of the genus Ganoderma P. Karst.: a review. RSC Adv. 2020 Nov 18;10(69):42084-42097. doi: 10.1039/d0ra07219b. PMID: 35516772; PMCID: PMC9057998.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057998/
44. El Dine RS, El Halawany AM, Ma CM, Hattori M. Inhibition of the dimerization and active site of HIV-1 protease by secondary metabolites from the Vietnamese mushroom Ganoderma colossum. J Nat Prod. 2009 Nov;72(11):2019-23. doi: 10.1021/np900279u. PMID: 19813754.
https://pubmed.ncbi.nlm.nih.gov/19813754/
45. El Dine RS, El Halawany AM, Ma CM, Hattori M. Anti-HIV-1 protease activity of lanostane triterpenes from the vietnamese mushroom Ganoderma colossum. J Nat Prod. 2008 Jun;71(6):1022-6. doi: 10.1021/np8001139. Epub 2008 Jun 12. PMID: 18547117.
https://pubmed.ncbi.nlm.nih.gov/18547117/
46. Sato N, Zhang Q, Ma CM, Hattori M. Anti-human immunodeficiency virus-1 protease activity of new lanostane-type triterpenoids from Ganoderma sinense. Chem Pharm Bull (Tokyo). 2009 Oct;57(10):1076-80. doi: 10.1248/cpb.57.1076. PMID: 19801861.
https://pubmed.ncbi.nlm.nih.gov/19801861/
47. el-Mekkawy S, Meselhy MR, Nakamura N, et al. Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. Phytochemistry. Nov 1998;49(6):1651-1657.
https://pubmed.ncbi.nlm.nih.gov/9862140/
48. Min BS, Nakamura N, Miyashiro H, et al. Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease. Chemical & pharmaceutical bulletin. Oct 1998;46(10):1607-1612.
https://pubmed.ncbi.nlm.nih.gov/9810695/
49. Kim, H.W., Shim, M.J., Choi, E.C. et al. Inhibition of cytopathic effect of human immunodeficiency virus-1 by water-soluble extract ofGanoderma lucidum . Arch. Pharm. Res. 20, 425–431 (1997). https://doi.org/10.1007/BF02973934
https://link.springer.com/article/10.1007/BF02973934
50. Kang, Devinna & Mutakin, Mutakin & Levita, Jutti. (2015). Computational Study of Triterpenoids of Ganoderma lucidum with Aspartic Protease Enzymes for Discovering HIV-1 and Plasmepsin Inhibitors. International Journal of Chemistry. 7. 62-68. 10.5539/ijc.v7n1p62.
https://pustaka.unpad.ac.id/archives/144063
51. Wang HX, Ng TB. A laccase from the medicinal mushroom Ganoderma lucidum. Appl Microbiol Biotechnol. 2006 Sep;72(3):508-13. doi: 10.1007/s00253-006-0314-9. Epub 2006 Apr 25. PMID: 16636832.
https://pubmed.ncbi.nlm.nih.gov/16636832/
52. FLÓREZ-SAMPEDRO, L., ZAPATA, W., Zapata, L. P., MEJÍA, A. I., ARBOLEDA, C., & RUGELES, M. T. (2016). In vitro anti-HIV-1 activity of the enzymatic extract enriched with laccase produced by the fungi Ganoderma sp. and Lentinus sp. Vitae, 23(2), 109–118. https://doi.org/10.17533/udea.vitae.v23n2a03
https://revistas.udea.edu.co/index.php/vitae/article/view/23524
53. Choengpanya K, Ratanabunyong S, Seetaha S, Tabtimmai L, Choowongkomon K. Anti-HIV-1 reverse transcriptase property of some edible mushrooms in Asia. Saudi J Biol Sci. 2021 May;28(5):2807-2815. doi: 10.1016/j.sjbs.2021.02.012. Epub 2021 Feb 16. PMID: 34012322; PMCID: PMC8116966.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116966/
54. Λοίμωξη με HIV Γραφική αναπαράσταση του κύκλου ζωής και αναπαραγωγής του ιού HIV
http://www.hivaids.gr/i/pliroforisi/kyklos
55. Ma B, Ren W, Zhou Y, Ma J, Ruan Y, Wen CN. Triterpenoids from the spores of Ganoderma lucidum. N Am J Med Sci. 2011 Nov;3(11):495-8. doi: 10.4297/najms.2011.3495. PMID: 22361494; PMCID: PMC3271404.
https://pubmed.ncbi.nlm.nih.gov/22361494/
56. Τζούπης Χαράλαμπος, Design of novel inhibitors for renin and HIV-1 protease, 10.12681/eadd/42598, 2014
https://phdtheses.ekt.gr/eadd/handle/10442/42598
57. Akbar R, Yam WK. Interaction of ganoderic acid on HIV related target: molecular docking studies. Bioinformation. 2011;7(8):413-7. doi: 10.6026/97320630007413. Epub 2011 Dec 21. PMID: 22347784; PMCID: PMC3280442.
https://pubmed.ncbi.nlm.nih.gov/22347784/
58. Clinical Naturopathic Medicine by Hechtman, 2nd Edition, Leah Hechtman, 2019, 9780729542425
https://www.vasiliadis-books.gr/shop/clinical-naturopathic-medicine-by-hechtman-2nd-edition/
https://books.google.gr/books?id=Z9cMOSbgozIC&pg=PA382&lpg=PA382&dq=hiv+Ganoderma&source=bl&ots=OvRicdzIlT&sig=ACfU3U2WoAvOMh-ZvCVoU0T1rb-H6cf1rA&hl=el&sa=X&ved=2ahUKEwit0YWinfGEAxUsBNsEHRiiDyY4HhDoAXoECAMQAw#v=onepage&q=hiv%20Ganoderma&f=false
59. Ganoderma Cultivation, Chemistry and Medicinal Applications, Volume 1 Edited By Krishnendu Acharya, Somanjana Khatua Copyright 2024
https://www.routledge.com/Ganoderma-Cultivation-Chemistry-and-Medicinal-Applications-Volume--1/Acharya-Khatua/p/book/9781032397610
https://books.google.gr/books?id=BbrxEAAAQBAJ&pg=PT187&lpg=PT187&dq=hiv+Ganoderma&source=bl&ots=rDecAQUmnO&sig=ACfU3U0hjGRFTkj0HuVn97DPRnuNd1pa_A&hl=el&sa=X&ved=2ahUKEwiMw_WunfGEAxWCefEDHQ8fB604KBDoAXoECAMQAw#v=onepage&q=hiv%20Ganoderma&f=false
60. Prof. Lin Zhanxi & Mdm Lin D.M. Fujian Agriculture and Forestry University (FAFU) Fujian Province JUNCAO Bio-Engineering Center, 2009
http://ls.china-embassy.gov.cn/eng/sgdt/200904/P020210828154351689068.pdf
61. Αριθμός CD4 κυττάρων, Lab Tests Online, Ελληνική Εταιρεία Κλινικής Χημείας-Κλινικής Βιοχημείας
http://www.labtestsonline.gr/tests/CD4.html?tab=6
62. Mohan, S. & Chinnaswamy, P. & S., Krishnamoorthy. (2005). A Study on the Effect of Ganoderma lucidum (W.Curt.: Fr.) Lloyd in Indian HIV Carriers. International Journal of Medicinal Mushrooms. 7. 431-432. 10.1615/IntJMedMushr.v7.i3.750.
https://www.dl.begellhouse.com/journals/708ae68d64b17c52,0d0f121956dd501b,23171b8261ba4b96.html
63. Gonkhom, Didsanutda & Luangharn, Thatsanee & Raghoonundon, Bhavesh & Hyde, Kevin & Stadler, Marc & Thongklang, Naritsada. (2021). Hericium: A review of the cultivation, health-enhancing applications, economic importance, industrial, and pharmaceutical applications. Fungal Biotec. 1. 115-127. 10.5943/FunBiotec/1/2/8.
https://www.researchgate.net/publication/357340574_Hericium_A_review_of_the_cultivation_health-enhancing_applications_economic_importance_industrial_and_pharmaceutical_applications
64. Guo-Qing Zhang, Qing-Jun Chen, Jing Hua, Zi-Lu Liu, Yue Sun, Xin Xu, Peng Han, He-Xiang Wang, "An Inulin-Specific Lectin with Anti-HIV-1 Reverse Transcriptase, Antiproliferative, and Mitogenic Activities from the Edible Mushroom Agaricus bitorquis", BioMed Research International, vol. 2019, Article ID 1341370, 9 pages, 2019. https://doi.org/10.1155/2019/1341370
https://www.hindawi.com/journals/bmri/2019/1341370/
65. Li Y, Zhang G, Ng TB, Wang H. A novel lectin with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from dried fruiting bodies of the monkey head mushroom Hericium erinaceum. J Biomed Biotechnol. 2010;2010:716515. doi: 10.1155/2010/716515. Epub 2010 Jun 13. PMID: 20625408; PMCID: PMC2896861.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896861/
66. Hassan, Mohamed & Rouf, Razina & Tiralongo, Evelin & May, Tom & Tiralongo, Joe. (2015). Mushroom Lectins: Specificity, Structure and Bioactivity Relevant to Human Disease. International Journal of Molecular Sciences. 16. 7802-7838. 10.3390/ijms16047802.
https://www.researchgate.net/figure/Anti-HIV-1-reverse-transcriptase-activity-of-mushroom-lectins_tbl10_275240899
https://www.researchgate.net/publication/275240899_Mushroom_Lectins_Specificity_Structure_and_Bioactivity_Relevant_to_Human_Disease
67. Oke MA, Afolabi FJ, Oyeleke OO, Kilani TA, Adeosun AR, Olanbiwoninu AA and Adebayo EA (2022) Ganoderma lucidum: Unutilized natural medicine and promising future solution to emerging diseases in Africa. Front. Pharmacol. 13:952027. doi: 10.3389/fphar.2022.952027
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.952027/full
68. 2nd Edition Encyclopedia of Dietary Supplements Edited By Paul M. Coates, Joseph M. Betz, Marc R. Blackman, Gordon M. Cragg, Mark Levine, Joel Moss, Jeffrey D. White
https://www.routledge.com/Encyclopedia-of-Dietary-Supplements/Coates-Betz-Blackman-Cragg-Levine-Moss-White/p/book/9781439819289
https://books.google.gr/books?id=WoW1DwAAQBAJ&pg=PA686&lpg=PA686&dq=reishi+reverse+transcriptase+ic50&source=bl&ots=oul3X8NRfw&sig=ACfU3U3P0QW3DhQ5smtG_EAxzd0RZLQNyQ&hl=el&sa=X&ved=2ahUKEwjg1tTupviEAxVQQPEDHch4DTE4FBDoAXoECAIQAw#v=onepage&q=reishi%20reverse%20transcriptase%20ic50&f=false
69. Παγκόσμια Ημέρα κατά του AIDS 01/12/2014, Υπουργείο Υγείας
https://www.moh.gov.gr/articles/news/2075-pagkosmia-hmera-kata-toy-aids
71. Zhao Y, Tian N, Wang H, Yan H. Chemically Sulfated Polysaccharides from Agaricus blazei Murill: Synthesis, Characterization and Anti-HIV Activity. Chem Biodivers. 2021 Sep;18(9):e2100338. doi: 10.1002/cbdv.202100338. Epub 2021 Aug 9. PMID: 34296822.
https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202100338
72. Sorimachi K, Nakamoto T. Alternative medicine safety: Agaricus blazei and propolis. Comb Chem High Throughput Screen. 2011 Aug;14(7):616-21. doi: 10.2174/138620711796367238. PMID: 21599627.
https://www.ingentaconnect.com/content/ben/cchts/2011/00000014/00000007/art00006?crawler=true
73. Huang K, El-Seedi HR, Xu B. Critical review on chemical compositions and health-promoting effects of mushroom <i>Agaricus blazei</i> Murill. Current Research in Food Science. 2022 ;5:2190-2203. DOI: 10.1016/j.crfs.2022.10.029. PMID: 36387602; PMCID: PMC9661389.
https://europepmc.org/article/med/36387602
74. Handema, R., Terunuma, H. and Kasolo, F. (2007). A prospective study of agaricus blazei mycelia compound administration in asymptomatic HIV-1 infected patients in Lusaka, Zambia. Medical Journal of Zambia. 34, (1)
https://library.adhl.africa/handle/123456789/11256
75. Corcorran MA, Kim N. Chronic hepatitis B and HIV coinfection. Top Antivir Med. 2023 Mar 31;31(1):14-22. PMID: 37018732; PMCID: PMC10089291.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089291/
76. Ήπαρ, Ιωάννης Κιούσης, Στέλεχος Διατροφής και Διαιτολογίας, 13/4/2022
https://www.farmakeftikamanitaria.gr/cordyceps-ipatika-ofeli.html
77. Ηπατίτιδα Β, Ιωάννης Κιούσης, Στέλεχος Διατροφής και Διαιτολογίας, 24/10/2022
https://www.farmakeftikamanitaria.gr/ganoderma-ipatitida-b.html
78. Hsu CH, Hwang KC, Chiang YH, Chou P. The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B. J Altern Complement Med. 2008 Apr;14(3):299-301. doi: 10.1089/acm.2006.6344. PMID: 18370584.
https://pubmed.ncbi.nlm.nih.gov/18370584/
79. The Impact of HIV/AIDS on the Liver December 9, 2022 | By Haley Wilson, arizona liver health
https://azliver.com/blog/the-impact-of-hiv-aids-on-the-liver/
80. Sherman KE, Thomas DL. HIV and liver disease: a comprehensive update. Top Antivir Med. 2022 Oct;30(4):547-558. PMID: 36375129; PMCID: PMC9681142.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681142/
81. HIV and Diabetes Last Reviewed: August 10, 2021, NIH Office of AIDS Research
https://hivinfo.nih.gov/understanding-hiv/fact-sheets/hiv-and-diabetes
82. Kibirige, D., Sekitoleko, I., Owarwo, N. et al. HIV infection in adult Ugandans with new-onset type 2 diabetes: exploring its influence on the anthropometric and metabolic profile. AIDS Res Ther 20, 56 (2023). https://doi.org/10.1186/s12981-023-00553-9
https://aidsrestherapy.biomedcentral.com/articles/10.1186/s12981-023-00553-9
83. Bratt G, Brännström J, Missalidis C, Nyström T (2021) Development of type 2 diabetes and insulin resistance in people with HIV infection: Prevalence, incidence and associated factors. PLoS ONE 16(6): e0254079. https://doi.org/10.1371/journal.pone.0254079
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254079
84. Διαβήτης και κόρντισεπς,
https://www.farmakeftikamanitaria.gr/diabetes-korntiseps.html
85. Διαβήτης, Ιωάννης Κιούσης, Στέλεχος Διατροφής και Διαιτολογίας 28/1/2024
https://www.farmakeftikamanitaria.gr/ganoderma-diavhths.html
86. Hsu CH, Liao YL, Lin SC, Hwang KC, Chou P. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med. 2007 Jan-Feb;13(1):97-102. doi: 10.1089/acm.2006.6054. PMID: 17309383.
https://pubmed.ncbi.nlm.nih.gov/17309383/
87. Radovanović Spurnić A, Brmbolić B, Stojšić Z, Pekmezović T, Bukumirić Z, Korać M, Salemović D, Pešić-Pavlović I, Stevanović G, Milošević I, Jevtović D. The increasing prevalence of HIV/Helicobacter pylori co-infection over time, along with the evolution of antiretroviral therapy (ART). PeerJ. 2017 May 30;5:e3392. doi: 10.7717/peerj.3392. PMID: 28584718; PMCID: PMC5452935.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452935/
88. Nkuize M, De Wit S. Issues Related to the Treatment of H. pylori Infection in People Living with HIV and Receiving Antiretrovirals. Microorganisms. 2022 Jul 29;10(8):1541. doi: 10.3390/microorganisms10081541. PMID: 36013959; PMCID: PMC9413132.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413132/
89. Panos GZ, Xirouchakis E, Tzias V, Charatsis G, Bliziotis IA, Doulgeroglou V, Margetis N, Falagas ME. Helicobacter pylori infection in symptomatic HIV-seropositive and -seronegative patients: a case-control study. AIDS Res Hum Retroviruses. 2007 May;23(5):709-12. doi: 10.1089/aid.2006.0174. PMID: 17530997.
https://pubmed.ncbi.nlm.nih.gov/17530997/
90. Ιωάννης Κιούσης, Στέλεχος Διατροφής και Διαιτολογίας, 7/3/2024, τι σκοτώνει το ελικοβακτηρίδιο
https://www.farmakeftikamanitaria.gr/ti-skotonei-to-elikovaktiridio.html
91. Sleep Disorders and HIV, fact sheet by John-Manuel Andriote, American Psychiatric Association, HIV Psychiatry, www.psychiatry.org/AIDS.
https://www.psychiatry.org/File%20Library/Psychiatrists/Practice/Professional-Topics/HIV-Psychiatry/FactSheet-Insomnia-2012.pdf
92. Tsai YT, Chuang TJ, Mudiyanselage SPK, Ku HC, Wu YL, Li CY, Ko NY. The impact of sleep disturbances on suicide risk among people living HIV: An eleven-year national cohort. J Affect Disord. 2024 Feb 1;346:122-132. doi: 10.1016/j.jad.2023.10.045. Epub 2023 Oct 25. PMID: 37890538.
https://pubmed.ncbi.nlm.nih.gov/37890538/
93. Dabaghzadeh F, Khalili H, Ghaeli P, Alimadadi A. Sleep Quality and Its Correlates in HIV Positive Patients Who Are Candidates for Initiation of Antiretroviral Therapy. Iran J Psychiatry. 2013 Oct;8(4):160-4. PMID: 25628708; PMCID: PMC4281649.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281649/
94. Αϋπνια Φυσική Αντιμετώπιση, Ιωάννης Κιούσης, Στέλεχος Διατροφής και Διαιτολογίας 31/12/2023
https://www.farmakeftikamanitaria.gr/aypnia-fysiki-antimetopisi.html
95. HIV and AIDS and Mental Health, National Institute of Mental Health, November 2023
https://www.nimh.nih.gov/health/topics/hiv-aids
96. Tran BX, Ho RCM, Ho CSH, Latkin CA, Phan HT, Ha GH, Vu GT, Ying J, Zhang MWB. Depression among Patients with HIV/AIDS: Research Development and Effective Interventions (GAPRESEARCH). Int J Environ Res Public Health. 2019 May 19;16(10):1772. doi: 10.3390/ijerph16101772. PMID: 31109139; PMCID: PMC6571985.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571985/
97. Mudra Rakshasa-Loots, A., Whalley, H.C., Vera, J.H. et al. Neuroinflammation in HIV-associated depression: evidence and future perspectives. Mol Psychiatry 27, 3619–3632 (2022). https://doi.org/10.1038/s41380-022-01619-2
https://www.nature.com/articles/s41380-022-01619-2
98. Evid Based Complement Alternat Med, 2019, 7861297 2019 Apr 18 eCollection 2019 Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? Luisella Vigna, Federica Morelli, Gianna M Agnelli, Filomena Napolitano, Daniela Ratto, Alessandra Occhinegro, Carmine Di Iorio, Elena Savino, Carolina Girometta, Federico Brandalise, Paola Rossi
https://pubmed.ncbi.nlm.nih.gov/31118969
99. Biomed Res, 31 (4), 231-7 Aug 2010 Reduction of Depression and Anxiety by 4 Weeks Hericium Erinaceus Intake Mayumi Nagano, Kuniyoshi Shimizu, Ryuichiro Kondo, Chickako Hayashi, Daigo Sato, Katsuyuki Kitagawa, Koichiro Ohnuki
https://pubmed.ncbi.nlm.nih.gov/20834180
100. Das G, Shin HS, Leyva-Gómez G, Prado-Audelo MLD, Cortes H, Singh YD, Panda MK, Mishra AP, Nigam M, Saklani S, Chaturi PK, Martorell M, Cruz-Martins N, Sharma V, Garg N, Sharma R, Patra JK. Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials. Front Pharmacol. 2021 Feb 8;11:602364. doi: 10.3389/fphar.2020.602364. PMID: 33628175; PMCID: PMC7898063.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898063/
101. Yadav, Ramniwas. “Entomopathogenic Mushroom (Cordyceps sp.) as Immunity Booster.” (2020).
https://www.semanticscholar.org/paper/Entomopathogenic-Mushroom-%28Cordyceps-sp.%29-as-Yadav/76fee5978329a900848ac706a02887b36650109e
102. Jung, SJ., Jung, ES., Choi, EK. et al. Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial. BMC Complement Altern Med 19, 77 (2019). https://doi.org/10.1186/s12906-019-2483-y
https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-019-2483-y
103. Wang C, Wang J, Qi Y. Adjuvant treatment with Cordyceps sinensis for lung cancer: A systematic review and meta-analysis of randomized controlled trials. J Ethnopharmacol. 2024 Mar 12;327:118044. doi: 10.1016/j.jep.2024.118044. Epub ahead of print. PMID: 3848495
https://pubmed.ncbi.nlm.nih.gov/38484953/
104. Gong HY, Wang KQ, Tang SG. [Effects of cordyceps sinensis on T lymphocyte subsets and hepatofibrosis in patients with chronic hepatitis B]. Hunan Yi Ke Da Xue Xue Bao. 2000 Jun 28;25(3):248-50. Chinese. PMID: 12212155.
https://pubmed.ncbi.nlm.nih.gov/12212155/
105. Zhu JL, Liu C. [Modulating effects of extractum semen Persicae and cultivated Cordyceps hyphae on immuno-dysfunction of inpatients with posthepatitic cirrhosis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1992 Apr;12(4):207-9, 195. Chinese. PMID: 1498539.
https://pubmed.ncbi.nlm.nih.gov/1498539/
106. 徐佳吟、陳俊良、楊賢鴻（2011）。Effect of Cultured Mycelia Cordyceps Sinensis on Neutrophil and T- Cell- Mediated Immune Response in Humans。中醫藥雜誌，22(3&4)，161-172 https://doi.org/10.6940/JCM.201112_22(3_4).04
https://www.airitilibrary.com/Article/Detail/10176446-201112-201201050032-201201050032-38-49
107.Wachtel-Galor S, Tomlinson B, Benzie IF. Ganoderma lucidum ("Lingzhi"), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study. Br J Nutr. 2004 Feb;91(2):263-9. doi: 10.1079/BJN20041039. PMID: 14756912.
https://pubmed.ncbi.nlm.nih.gov/14756912/
108. Reishi Mushroom Purported Benefits, Side Effects & More, Memorial Sloan Kettering Cancer Center, February 9, 2023
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/reishi-mushroom
109. Ekiz, Elif, Emel Oz, A. M. Abd El-Aty, Charalampos Proestos, Charles Brennan, Maomao Zeng, Igor Tomasevic, Tahra Elobeid, Kenan Çadırcı, Muharrem Bayrak, and et al. 2023. "Exploring the Potential Medicinal Benefits of Ganoderma lucidum: From Metabolic Disorders to Coronavirus Infections" Foods 12, no. 7: 1512. https://doi.org/10.3390/foods12071512
https://www.mdpi.com/2304-8158/12/7/1512
110. Gao Y, Zhou S, Jiang W, Huang M, Dai X. Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Immunol Invest. 2003 Aug;32(3):201-15. doi: 10.1081/imm-120022979. PMID: 12916709.
https://pubmed.ncbi.nlm.nih.gov/12916709/
111. Sun LX, Li WD, Lin ZB, Duan XS, Li XF, Yang N, Lan TF, Li M, Sun Y, Yu M, Lu J. Protection against lung cancer patient plasma-induced lymphocyte suppression by Ganoderma lucidum polysaccharides. Cell Physiol Biochem. 2014;33(2):289-99. doi: 10.1159/000356669. Epub 2014 Jan 31. PMID: 24525691.
https://pubmed.ncbi.nlm.nih.gov/24525691/
112. Jin X, Ruiz Beguerie J, Sze DM, Chan GC. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane Database Syst Rev. 2016 Apr 5;4(4):CD007731. doi: 10.1002/14651858.CD007731.pub3. PMID: 27045603; PMCID: PMC6353236.
https://pubmed.ncbi.nlm.nih.gov/27045603/
113. Duque Henao, Sandra & Urrego, Sergio & Cano, Andrea & Higuita, Edwin. (2018). Randomized Clinical Trial for the Evaluation of Immune Modulation by Yogurt Enriched with β-Glucans from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Children from Medellin, Colombia. International Journal of Medicinal Mushrooms. 20. 705.
https://www.researchgate.net/publication/328676151_Randomized_Clinical_Trial_for_the_Evaluation_of_Immune_Modulation_by_Yogurt_Enriched_with_b-Glucans_from_Lingzhi_or_Reishi_Medicinal_Mushroom_Ganoderma_lucidum_Agaricomycetes_in_Children_from_Medellin
114. Chen, Shiu-Nan, Fan-Hua Nan, Ming-Wei Liu, Min-Feng Yang, Ya-Chih Chang, and Sherwin Chen. 2023. "Evaluation of Immune Modulation by β-1,3; 1,6 D-Glucan Derived from Ganoderma lucidum in Healthy Adult Volunteers, A Randomized Controlled Trial" Foods 12, no. 3: 659. https://doi.org/10.3390/foods12030659
https://www.mdpi.com/2304-8158/12/3/659
115. Zhong L, Yan P, Lam WC, Yao L, Bian Z. Coriolus Versicolor and Ganoderma Lucidum Related Natural Products as an Adjunct Therapy for Cancers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front Pharmacol. 2019 Jul 3;10:703. doi: 10.3389/fphar.2019.00703. PMID: 31333449; PMCID: PMC6616310.
https://pubmed.ncbi.nlm.nih.gov/31333449/
116. Zhang S, Pang G, Chen C, Qin J, Yu H, Liu Y, Zhang X, Song Z, Zhao J, Wang F, Wang Y, Zhang LW. Effective cancer immunotherapy by Ganoderma lucidum polysaccharide-gold nanocomposites through dendritic cell activation and memory T cell response. Carbohydr Polym. 2019 Feb 1;205:192-202. doi: 10.1016/j.carbpol.2018.10.028. Epub 2018 Oct 13. PMID: 30446095.
https://pubmed.ncbi.nlm.nih.gov/30446095/
117. Αθλητική Απόδοση, Αντοχή και Διάρκεια Ιωάννης Κιούσης, Στέλεχος Διατροφής και Διαιτολογίας. Τελευταία ενημέρωση: 10/1/2024
https://www.farmakeftikamanitaria.gr/cordyceps-athlitikes-epidoseis.html
118. Jakopovich I. New dietary supplements from medicinal mushrooms: Dr Myko San--a registration report. Int J Med Mushrooms. 2011;13(3):307-13. doi: 10.1615/intjmedmushr.v13.i3.110. PMID: 22135883.
https://pubmed.ncbi.nlm.nih.gov/22135883/
Διαβήτης
1.Diabetes, Cleveland Clinic, 02/17/2023
https://my.clevelandclinic.org/health/diseases/7104-diabetes
2.Hossain MJ, Al-Mamun M, Islam MR. Diabetes mellitus, the fastest growing global public health concern: Early detection should be focused. Health Sci Rep. 2024 Mar 22;7(3):e2004. doi: 10.1002/hsr2.2004. PMID: 38524769; PMCID: PMC10958528.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10958528/
3.Chapter 3Global picture, IDF DIABETES ATLAS [Internet]. 10th edition.
https://www.ncbi.nlm.nih.gov/books/NBK581940/
4.Prof. Dr. Taj Jamshaid. Diabetes Mellitus – The Epidemic of 21 Century. Esculapio - JSIMS [Internet]. 2023 May 13 [cited 2025 Nov. 23];19(01):1-2. Available from: https://esculapio.pk/journal/index.php/journal-files/article/view/272
https://esculapio.pk/journal/index.php/journal-files/article/view/272
5.Konstantinos Makrilakis, Natasa Kalpourtzi, Ioannis Ioannidis, Stella Iraklianou, Athanasios Raptis, Alexis Sotiropoulos, Magda Gavana, Apostolos Vantarakis, Maria Kantzanou, Christos Hadjichristodoulou, Grigoris Chlouverakis, Grigoris Trypsianis, Paraskevi V. Voulgari, Yannis Alamanos, Giota Touloumi, Stavros Liatis, Prevalence of diabetes and pre-diabetes in Greece. Results of the First National Survey of Morbidity and Risk Factors (EMENO) study, Diabetes Research and Clinical Practice, Volume 172, 2021, 108646, ISSN 0168-8227, https://doi.org/10.1016/j.diabres.2020.108646.
https://www.sciencedirect.com/science/article/abs/pii/S0168822720309037
6.Diabetes mellitus, LEFKOS STAVROS
https://lefkosstavros.gr/en/diabetes-mellitus/
7.Type 2 diabetes, Feb. 27, 2025, Mayo Foundation for Medical Education and Research
https://www.mayoclinic.org/diseases-conditions/type-2-diabetes/symptoms-causes/syc-20351193
8.Type 2 Diabetes, Last Reviewed May 2017, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK),
https://www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes/type-2-diabetes
9. Type 1 diabetes medicine, 08 June 2023, British Diabetic Association
https://www.diabetes.org.uk/about-diabetes/type-1-diabetes/treatments/medicine
10. Insulin and type 2 diabetes, British Diabetic Association
https://www.diabetes.org.uk/about-diabetes/looking-after-diabetes/treatments/insulin/type-2-diabetes
11.Dahlén AD, Dashi G, Maslov I, Attwood MM, Jonsson J, Trukhan V, Schiöth HB. Trends in Antidiabetic Drug Discovery: FDA Approved Drugs, New Drugs in Clinical Trials and Global Sales. Front Pharmacol. 2022 Jan 19;12:807548. doi: 10.3389/fphar.2021.807548. PMID: 35126141; PMCID: PMC8807560.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8807560/
12.Usai R, Majoni S and Rwere F (2022) Natural products for the treatment and management of diabetes mellitus in Zimbabwe-a review. Front. Pharmacol. 13:980819. doi: 10.3389/fphar.2022.980819
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.980819/full
13. Weinberg Sibony, R.; Segev, O.; Dor, S.; Raz, I. Drug Therapies for Diabetes. Int. J. Mol. Sci. 2023, 24, 17147. https://doi.org/10.3390/ijms242417147
https://www.mdpi.com/1422-0067/24/24/17147
14. Are Antidiabetic Drugs Safe in the Long Term? Global Forum, V. Mohan Diabetes Specialities Centre and Madras Diabetes Research Foundation
https://globalforum.diaglobal.org/issue/march-2021/are-antidiabetic-drugs-safe-in-the-long-term/
15. Weinberg Sibony, R.; Segev, O.; Dor, S.; Raz, I. Drug Therapies for Diabetes. Int. J. Mol. Sci. 2023, 24, 17147. https://doi.org/10.3390/ijms242417147
https://www.mdpi.com/1422-0067/24/24/17147
16. Gulam, Shabaz & Palaian, Subish & Shankar, P Ravi & Sam, Kishore & Kumar, Mukesh. (2019). UNCOMMON SIDE EFFECTS OF COMMONLY USED ANTI-DIABETICS: TIME TO MONITOR THEM. International Journal of Pharmaceutical Sciences and Research. 10. 4145.
https://www.researchgate.net/publication/340077756_UNCOMMON_SIDE_EFFECTS_OF_COMMONLY_USED_ANTI-DIABETICS_TIME_TO_MONITOR_THEM
17. Oral & Injectable Medications for Type 2 Diabetes, American Diabetes Association,
https://diabetes.org/health-wellness/medication/oral-other-injectable-diabetes-medications
18. Chandrasekaran, P.; Weiskirchen, R. The Role of Obesity in Type 2 Diabetes Mellitus—An Overview. Int. J. Mol. Sci. 2024, 25, 1882. https://doi.org/10.3390/ijms25031882
https://www.mdpi.com/1422-0067/25/3/1882
19.Asgari S, Masrouri S, Khalili D, Lotfaliany M, Hadaegh F. Weight Gain, Weight Loss, and Type 2 Diabetes Risk: Evidence From the Atherosclerosis Risk in Communities (ARIC) Study. Endocrinol Diabetes Metab. 2025 May;8(3):e70040. doi: 10.1002/edm2.70040. PMID: 40198876; PMCID: PMC11978231.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11978231/
20.Yedjou CG, Grigsby J, Mbemi A, Nelson D, Mildort B, Latinwo L, Tchounwou PB. The Management of Diabetes Mellitus Using Medicinal Plants and Vitamins. Int J Mol Sci. 2023 May 22;24(10):9085. doi: 10.3390/ijms24109085. PMID: 37240430; PMCID: PMC10218826.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10218826/
21.Usai R, Majoni S, Rwere F. Natural products for the treatment and management of diabetes mellitus in Zimbabwe-a review. Front Pharmacol. 2022 Aug 24;13:980819. doi: 10.3389/fphar.2022.980819. PMID: 36091798; PMCID: PMC9449367.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9449367/
22.Sknepnek A, Miletić D, Stupar A, Salević-Jelić A, Nedović V and Cvetanović Kljakić A (2025) Natural solutions for diabetes: the therapeutic potential of plants and mushrooms. Front. Nutr. 12:1511049. doi: 10.3389/fnut.2025.1511049
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1511049/full
23.Shamim MZ, Mishra AK, Kausar T, Mahanta S, Sarma B, Kumar V, Mishra PK, Panda J, Baek KH, Mohanta YK. Exploring Edible Mushrooms for Diabetes: Unveiling Their Role in Prevention and Treatment. Molecules. 2023 Mar 21;28(6):2837. doi: 10.3390/molecules28062837. PMID: 36985818; PMCID: PMC10058372.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10058372/
24. Németh, Z.; Paulinné Bukovics, M.; Sümegi, L.D.; Sturm, G.; Takács, I.; Simon-Szabó, L. The Importance of Edible Medicinal Mushrooms and Their Potential Use as Therapeutic Agents Against Insulin Resistance. Int. J. Mol. Sci. 2025, 26, 827. https://doi.org/10.3390/ijms26020827
https://www.mdpi.com/1422-0067/26/2/827
25. Mohammad Azizur Rahman and Rabeya Akter, (2022). Diabetes Ameliorating Effect of Mushrooms. J. Diabetes and Islet Biology, 5(1); DOI:10.31579/2641-8975/026
https://www.auctoresonline.org/article/diabetes-ameliorating-effect-of-mushrooms-and-ameliorating-diabetes
26.Rubiya Khursheed, Sachin Kumar Singh, Sheetu Wadhwa, Monica Gulati, Ankit Awasthi, Therapeutic potential of mushrooms in diabetes mellitus: Role of polysaccharides, International Journal of Biological Macromolecules, Volume 164, 2020, Pages 1194-1205, ISSN 0141-8130, https://doi.org/10.1016/j.ijbiomac.2020.07.145.
https://www.sciencedirect.com/science/article/abs/pii/S0141813020339088
27. HURIEZ C. Indications actuelles de la mycothérapie [Current indications of mycotherapy]. Paris Med. 1945 Nov 30;35:374-80. French. PMID: 21021559.
https://pubmed.ncbi.nlm.nih.gov/21021559/
28. DIOT. Premiers essais de mycothérapie dans les affections pyogènes et leurs résultats [First trials of mycotherapy in pyogenic conditions and their results]. Maroc Med. 1946 Feb-Mar;25(258):10-2. French. PMID: 20993868.
https://pubmed.ncbi.nlm.nih.gov/20993868/
29. CHABROL E. La mycothérapie dans les cirrhoses du foie [Mycotherapy in liver cirrhosis]. Presse Therm Clim. 1949 Jan-Feb;86(1-2):1-5. French. PMID: 18115812.
https://pubmed.ncbi.nlm.nih.gov/18115812/
30. KOURILSKY R. La mycothérapie dans la tuberculose pulmonaire chronique [Mycotherapy in chronic pulmonary tuberculosis]. Laval Med. 1949 Dec;14(10):1319-40. French. PMID: 15408327.
https://pubmed.ncbi.nlm.nih.gov/15408327/
31. Medicinal Mushrooms (PDQ®)–Patient Version, July 11, 2024, National Cancer Institute at the National Institutes of Health https://www.cancer.gov/about-cancer/treatment/cam/patient/mushrooms-pdq
32. Alaa A.M. Osman, Adrienn Seres-Bokor, Eszter Ducza, Diabetes mellitus therapy in the light of oxidative stress and cardiovascular complications, Journal of Diabetes and its Complications, Volume 39, Issue 2, 2025, 108941, ISSN 1056-8727, https://doi.org/10.1016/j.jdiacomp.2024.108941.
https://www.sciencedirect.com/science/article/pii/S1056872724002678
33. Caturano A, D'Angelo M, Mormone A, Russo V, Mollica MP, Salvatore T, Galiero R, Rinaldi L, Vetrano E, Marfella R, Monda M, Giordano A, Sasso FC. Oxidative Stress in Type 2 Diabetes: Impacts from Pathogenesis to Lifestyle Modifications. Curr Issues Mol Biol. 2023 Aug 12;45(8):6651-6666. doi: 10.3390/cimb45080420. PMID: 37623239; PMCID: PMC10453126.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10453126/
34. Asmat U, Abad K, Ismail K. Diabetes mellitus and oxidative stress-A concise review. Saudi Pharm J. 2016 Sep;24(5):547-553. doi: 10.1016/j.jsps.2015.03.013. Epub 2015 Mar 21. PMID: 27752226; PMCID: PMC5059829.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5059829/
35. Yueting Cai, Shuiqing Hu, Jingrui Liu, Jinlan Luo, Wenhua Li, Jiaxin Tang, Siyang Liu, Ruolan Dong, Yan Yang, Ling Tu, Xizhen Xu, Diabetic vascular calcification inhibited by soluble epoxide hydrolase gene deletion via regressing NID2-mediated IGF2-ERK1/2 signaling pathway, Chinese Medical Journal, 10.1097/CM9.0000000000003792, 138, 20, (2657-2668), (2025).
https://mednexus.org/doi/10.1097/CM9.0000000000003230
36. An, Y., Xu, Bt., Wan, Sr. et al. The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction. Cardiovasc Diabetol 22, 237 (2023). https://doi.org/10.1186/s12933-023-01965-7
https://cardiab.biomedcentral.com/articles/10.1186/s12933-023-01965-7
37.Giacco F, Brownlee M. Oxidative stress and diabetic complications. Circ Res. 2010 Oct 29;107(9):1058-70. doi: 10.1161/CIRCRESAHA.110.223545. PMID: 21030723; PMCID: PMC2996922.
https://www.ahajournals.org/doi/10.1161/circresaha.110.223545
38.Mwangi RW, Macharia JM, Wagara IN, Bence RL. The antioxidant potential of different edible and medicinal mushrooms. Biomed Pharmacother. 2022 Mar;147:112621. doi: 10.1016/j.biopha.2022.112621. Epub 2022 Jan 10. PMID: 35026489.
https://www.sciencedirect.com/science/article/pii/S0753332222000099
39. Podkowa, A., Kryczyk-Poprawa, A., Opoka, W. et al. Culinary–medicinal mushrooms: a review of organic compounds and bioelements with antioxidant activity. Eur Food Res Technol 247, 513–533 (2021). https://doi.org/10.1007/s00217-020-03646-1
https://link.springer.com/article/10.1007/s00217-020-03646-1
40. Aramabašić Jovanović J, Mihailović M, Uskoković A, Grdović N, Dinić S, Vidaković M. The Effects of Major Mushroom Bioactive Compounds on Mechanisms That Control Blood Glucose Level. J Fungi (Basel). 2021 Jan 16;7(1):58. doi: 10.3390/jof7010058. PMID: 33467194; PMCID: PMC7830770.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7830770/
41.Altaf S, Asmara, Iftikhar A and Muzaffar H, 2025. Pharmacological importance of medicinal mushroom Ganoderma specie for the treatment of diabetes. In: Khan A, Hussain R, Tahir S and Ghafoor N (eds), Medicinal Plants and Aromatics: A Holistic Health Perspective. Unique Scientific Publishers, Faisalabad, Pakistan, pp: 9-14. https://doi.org/10.47278/book.HH/2025.423
https://uniquescientificpublishers.com/pdf-files/HH/Medicinal-Plants-and-Aromatics/9-14.pdf
42. Aramabašić Jovanović, J.; Mihailović, M.; Uskoković, A.; Grdović, N.; Dinić, S.; Vidaković, M. The Effects of Major Mushroom Bioactive Compounds on Mechanisms That Control Blood Glucose Level. J. Fungi 2021, 7, 58. https://doi.org/10.3390/jof7010058
https://www.mdpi.com/2309-608X/7/1/58
43. Randeni, N., J. Luo, and B. Xu. 2025. “ Unveiling the Molecular Mechanisms of Natural Triterpenoids From Mushrooms Against Type 2 Diabetes: A Critical Review.” Phytotherapy Research 39, no. 8: 3466–3485. https://doi.org/10.1002/ptr.70030.
https://onlinelibrary.wiley.com/doi/10.1002/ptr.70030?af=R
44.Yingnan Jiang, Hongning Song, Guoying Zhang, Jianya Ling, The application of medicinal fungi from the subphylum Ascomycota in the treatment of type 2 diabetes, Journal of Future Foods, Volume 5, Issue 4, 2025, Pages 361-371, ISSN 2772-5669, https://doi.org/10.1016/j.jfutfo.2024.07.014.
https://www.sciencedirect.com/science/article/pii/S277256692400048X
45. Wu, Tong & Xu, Baojun. (2015). Antidiabetic and Antioxidant Activities of Eight Medicinal Mushroom Species from China. International journal of medicinal mushrooms. 17. 129-40. 10.1615/IntJMedMushrooms.v17.i2.40.
https://www.researchgate.net/publication/273326880_Antidiabetic_and_Antioxidant_Activities_of_Eight_Medicinal_Mushroom_Species_from_China
46. Alvandi, H., Ansari, E. ., Kianirad, S. ., Hatamian-Zarmi, A., Mokhtari Hosseini, Z. B., & Ebrahimi-Hosseinzadeh, B. (2022). Medicinal mushrooms as potential therapeutic agents in the treatment of diabetes mellitus: a review with focusing on in vivo and clinical studies. Italian Journal of Mycology, 51(1), 75–96. https://doi.org/10.6092/issn.2531-7342/15023
https://italianmycology.unibo.it/article/view/15023
47.De Silva, D.D., Rapior, S., Hyde, K.D. et al. Medicinal mushrooms in prevention and control of diabetes mellitus. Fungal Diversity 56, 1–29 (2012). https://doi.org/10.1007/s13225-012-0187-4
https://link.springer.com/article/10.1007/s13225-012-0187-4
48. Medicinal mushrooms show promise for combating insulin resistance February 25, 2025 By Angelika Erdélyi Semmelweis University
https://semmelweis.hu/english/2025/02/medicinal-mushrooms-show-promise-for-combating-insulin-resistance/
49. Ebru Deveci, Fatih Çayan, Gülsen Tel-Çayan, Mehmet Emin Duru, Inhibitory activities of medicinal mushrooms on α-amylase and α-glucosidase-enzymes related to type 2 diabetes, South African Journal of Botany, Volume 137, 2021, Pages 19-23, ISSN 0254-6299, https://doi.org/10.1016/j.sajb.2020.09.039.
https://www.sciencedirect.com/science/article/pii/S025462992031111X
50. Rašeta M, Popović M, Čapo I, Stilinović N, Vukmirović S, Milošević B, Karaman M. Antidiabetic effect of two different Ganoderma species tested in alloxan diabetic rats. RSC Adv. 2020 Mar 11;10(17):10382-10393. doi: 10.1039/c9ra10158f. PMID: 35498606; PMCID: PMC9050389.
https://pubs.rsc.org/en/content/articlehtml/2020/ra/c9ra10158f
51. Holmes, D. Medicinal mushroom reduces obesity by modulating microbiota. Nat Rev Endocrinol 11, 504 (2015). https://doi.org/10.1038/nrendo.2015.114
https://www.nature.com/articles/nrendo.2015.114
52. Al-Goblan AS, Al-Alfi MA, Khan MZ. Mechanism linking diabetes mellitus and obesity. Diabetes Metab Syndr Obes. 2014 Dec 4;7:587-91. doi: 10.2147/DMSO.S67400. PMID: 25506234; PMCID: PMC4259868.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259868/
53. Gao, Yihuai & Lan, Jin & Dai, Xihu & Ye, Jingxian & Zhou, Shufeng. (2004). A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum (W.Curt.:Fr.)Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms - INT J MED MUSHROOMS. 6. 33-40. 10.1615/IntJMedMushr.v6.i1.30.
https://www.researchgate.net/publication/247855021_A_Phase_III_Study_of_Ling_Zhi_Mushroom_Ganoderma_lucidum_WCurtFrLloyd_Aphyllophoromycetideae_Extract_in_Patients_with_Type_II_Diabetes_Mellitus
Α1. Tropical Journal of Pharmaceutical Research December 2023; 22 (12): 2561-2566 ISSN: 1596-5996 (print); 1596-9827 (electronic) © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria, view Article Hypoglycemic and glucose-lowering properties of Cordyceps militaris Phuong Dong Tran Nguyen1, Nguyen Binh Truong2, Thuan Duc Lao1
https://www.ajol.info/index.php/tjpr/article/view/262293
Α2. Huang, T., Zhou, Y., Lu, X., Tang, C., Ren, C., Bao, X., Deng, Z., Cao, X., Zou, J., Zhang, Q., & Ma, B. (2022). Cordycepin, a major bioactive component of Cordyceps militaris, ameliorates diabetes-induced testicular damage through the Sirt1/Foxo3a pathway. Andrologia, 54, e14294. https://doi.org/10.1111/and.14294
https://onlinelibrary.wiley.com/doi/pdf/10.1111/and.14294
Α3. Zhang J, Yang Z, Zhao Z and Zhang N (2024) Structural and pharmacological insights into cordycepin for neoplasms and metabolic disorders. Front. Pharmacol. 15:1367820. doi: 10.3389/fphar.2024.1367820
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1367820/full
Α4. Huizhen Sun, Anyong Zhang, Yanchun Gong, Wei Sun, Baiyi Yan, Shuihong Lei, Li-Hua Yao, Improving effect of cordycepin on insulin synthesis and secretion in normal and oxidative-damaged INS-1 cells, European Journal of Pharmacology, Volume 920, 2022, 174843, ISSN 0014-2999, https://doi.org/10.1016/j.ejphar.2022.174843.
https://www.sciencedirect.com/science/article/abs/pii/S0014299922001042
Α5. Baiyi Yan, Yanchun Gong, Wei Meng, Huizhen Sun, Wenxi Li, Kaizhi Ding, Caixia Dang, Xiaofei Gao, Wei Sun, Chunhua Yuan, Songhua Wang, Li-Hua Yao, Cordycepin protects islet β-cells against glucotoxicity and lipotoxicity via modulating related proteins of ROS/JNK signaling pathway, Biomedicine & Pharmacotherapy, Volume 163, 2023, 114776, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2023.114776.
https://www.sciencedirect.com/science/article/pii/S0753332223005656
Α6. Zheng, R., Zhang, W., Song, J. et al. Cordycepin from Cordyceps militaris ameliorates diabetic nephropathy via the miR-193b-5p/MCL-1 axis. Chin Med 18, 134 (2023). https://doi.org/10.1186/s13020-023-00842-5
https://cmjournal.biomedcentral.com/articles/10.1186/s13020-023-00842-5
Α7. Liu X, Dun M, Jian T, Sun Y, Wang M, Zhang G, Ling J. Cordyceps militaris extracts and cordycepin ameliorate type 2 diabetes mellitus by modulating the gut microbiota and metabolites. Front Pharmacol. 2023 Mar 9;14:1134429. doi: 10.3389/fphar.2023.1134429. PMID: 36969858; PMCID: PMC10033974.
https://pubmed.ncbi.nlm.nih.gov/36969858/
Α8. Cordyceps controls blood sugar levels, Bangkok,
https://www.bangkokhospital.com/en/content/cordyceps-with-diabetes
Α9. The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II. Zhu JS1, Halpern GM, Jones K., J Altern Complement Med. 1998 Winter;4(4):429-57.
Α10. Medicinal Mushrooms, A Clinical Guide by Martin Powell,
http://mycotherapyonline.com/carous/cordyceps/
Α11. Hsu CH, Liao YL, Lin SC, Hwang KC, Chou P. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med. 2007 Jan-Feb;13(1):97-102. doi: 10.1089/acm.2006.6054. PMID: 17309383.
https://pubmed.ncbi.nlm.nih.gov/17309383/
Γ51. Hsu PC, Tsai YT, Lai JN, Wu CT, Lin SK, Huang CY. Integrating traditional Chinese medicine healthcare into diabetes care by reducing the risk of developing kidney failure among type 2 diabetic patients: a population-based case control study. J Ethnopharmacol. 2014 Oct 28;156:358-64. doi: 10.1016/j.jep.2014.08.029. Epub 2014 Aug 29. PMID: 25178949.
https://pubmed.ncbi.nlm.nih.gov/25178949/
Γ52. Lee WC, Wu CC, Chuang YC, Tain YL, Chiang PH. Ba-Wei-Die-Huang-Wan (Hachimi-jio-gan) can ameliorate cyclophosphamide-induced ongoing bladder overactivity and acidic adenosine triphosphate solution-induced hyperactivity on rats prestimulated bladder. J Ethnopharmacol. 2016 May 26;184:1-9. doi: 10.1016/j.jep.2015.12.026. Epub 2015 Dec 21. PMID: 26719284.
https://pubmed.ncbi.nlm.nih.gov/26719284/
Γ54. Zhao J, Li Y, Xin L, Sun M, Yu C, Shi G, Bao T, Liu J, Ni Y, Lu R, Wu Y, Fang Z. Clinical Features and Rules of Chinese Herbal Medicine in Diabetic Peripheral Neuropathy Patients. Evid Based Complement Alternat Med. 2020 Jul 17;2020:5795264. doi: 10.1155/2020/5795264. PMID: 32724325; PMCID: PMC7382735.
https://pubmed.ncbi.nlm.nih.gov/32724325/
Γ55. Nie A, Chao Y, Zhang X, Jia W, Zhou Z, Zhu C. Phytochemistry and Pharmacological Activities of Wolfiporia cocos (F.A. Wolf) Ryvarden & Gilb. Front Pharmacol. 2020 Sep 15;11:505249. doi: 10.3389/fphar.2020.505249. PMID: 33071776; PMCID: PMC7533546.
https://pubmed.ncbi.nlm.nih.gov/33071776/
Γ56. Liu JP, Zhang M, Wang W, Grimsgaard S. Chinese herbal medicines for type 2 diabetes mellitus. Cochrane Database of Systematic Reviews 2002, Issue 3. Art. No.: CD003642. DOI: 10.1002/14651858.CD003642.pub2. Accessed 28 April 2022.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD003642.pub2/appendices
Γ58. Xia J, Zhang L, Zhang X, Wang L, Yang B, Chen Q, Zhong M, Tang X, Zhou J. Effect of large dosage of Fuling on urinary protein of diabetic nephropathy: A protocol of systematic review and meta-analysis of randomized clinical trials. Medicine (Baltimore). 2020 Oct 2;99(40):e22377. doi: 10.1097/MD.0000000000022377. PMID: 33019413; PMCID: PMC7535777.
https://pubmed.ncbi.nlm.nih.gov/33019413/
Δυσκοιλιότητα
423. Constipation, The Johns Hopkins University
https://www.hopkinsmedicine.org/health/conditions-and-diseases/constipation
424. Complications of Constipation, Stanford Health
https://stanfordhealthcare.org/medical-conditions/primary-care/constipation/complications.html
425. Sundbøll J, Szépligeti SK, Adelborg K, et al Constipation and risk of cardiovascular diseases: a Danish population-based matched cohort study BMJ Open 2020;10:e037080. doi: 10.1136/bmjopen-2020-037080
https://bmjopen.bmj.com/content/10/9/e037080
426. PRESS RELEASE Constipation Associated with Cognitive Aging and Decline Plus, Gut Bacteria Linked to Alzheimer’s Biomarkers, Dementia Risk, Alzheimer’s Association
https://aaic.alz.org/releases_2023/constipation-gut-health-alzheimers-dementia-risk.asp
427. Constipation and faecal impaction, Alzheimer Scotland
https://www.alzscot.org/our-work/dementia-support/information-sheets/constipation-and-faecal-impaction
428. Incontinence and constipation, Alzheimers New Zealand
https://alzheimers.org.nz/get-support/supporting-someone-with-dementia/incontinence-and-constipation/
429. Chen CL, Liang TM, Chen HH, Lee YY, Chuang YC, Chen NC. Constipation and Its Associated Factors among Patients with Dementia. Int J Environ Res Public Health. 2020 Dec 3;17(23):9006. doi: 10.3390/ijerph17239006. PMID: 33287267; PMCID: PMC7730313.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730313/
430. Editorial| Volume 4, ISSUE 11, P811, November 2019, The cost of constipation The Lancet Gastroenterology & Hepatology Published:November, 2019DOI:https://doi.org/10.1016/S2468-1253(19)30297-3
https://www.thelancet.com/journals/langas/article/PIIS2468-1253(19)30297-3/fulltext
431. Bellini, M.; Tonarelli, S.; Barracca, F.; Rettura, F.; Pancetti, A.; Ceccarelli, L.; Ricchiuti, A.; Costa, F.; de Bortoli, N.; Marchi, S.; et al. Chronic Constipation: Is a Nutritional Approach Reasonable? Nutrients 2021, 13, 3386. https://doi.org/10.3390/nu13103386
https://www.mdpi.com/2072-6643/13/10/3386
766. Wang R, Sun H, Yang T, Xu J. Causal relationship between hypertension and risk of constipation: A 2-way 2-sample Mendelian randomization study. Medicine (Baltimore). 2024 May 3;103(18):e38057. doi: 10.1097/MD.0000000000038057. PMID: 38701266; PMCID: PMC11062663.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11062663/
767. Wang, Junwen, Ye, Yuyang, Chen, Xuefeng, Hu, Xinru, Peng, Yong, Constipation and Cardiovascular Mortality Risk in Patients With Hypertension: A Long-Term Cohort Study, International Journal of Hypertension, 2025, 9921027, 9 pages, 2025. https://doi.org/10.1155/ijhy/9921027
https://onlinelibrary.wiley.com/doi/10.1155/ijhy/9921027
768. Sumida K, Molnar MZ, Potukuchi PK, Thomas F, Lu JL, Yamagata K, Kalantar-Zadeh K, Kovesdy CP. Constipation and risk of death and cardiovascular events. Atherosclerosis. 2019 Feb;281:114-120. doi: 10.1016/j.atherosclerosis.2018.12.021. Epub 2018 Dec 23. PMID: 30658186; PMCID: PMC6399019.https://pmc.ncbi.nlm.nih.gov/articles/PMC6399019/
769. Liu B, Wu X, Wang Y, Hu X. Association between constipation and risk of cardiovascular or all-cause mortality: a meta-analysis. Ann Med. 2025 Dec;57(1):2561803. doi: 10.1080/07853890.2025.2561803. Epub 2025 Sep 22. PMID: 40982729; PMCID: PMC12456042.
https://pubmed.ncbi.nlm.nih.gov/40982729/
Πάρκινσον
1. Yadav SK, Ir R, Jeewon R, Doble M, Hyde KD, Kaliappan I, Jeyaraman R, Reddi RN, Krishnan J, Li M, Durairajan SSK. A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders. Planta Med. 2020 Nov;86(16):1161-1175. doi: 10.1055/a-1177-4834. Epub 2020 Jul 14. PMID: 32663897.
https://pubmed.ncbi.nlm.nih.gov/32663897/
2. Quan Y, Ma A, Yang B. Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Brain Injury. Adv Exp Med Biol. 2019;1182:159-180. doi: 10.1007/978-981-32-9421-9_6. PMID: 31777018.
https://pubmed.ncbi.nlm.nih.gov/31777018/
3. Chen LW, Wang YQ, Wei LC, Shi M, Chan YS. Chinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinson's disease. CNS Neurol Disord Drug Targets. 2007 Aug;6(4):273-81. doi: 10.2174/187152707781387288. PMID: 17691984.
https://pubmed.ncbi.nlm.nih.gov/17691984/
4. Vo, T. S. & Vo, Tran Thi Bich Chau & Vo, Tran Thi Thu Ngoc. (2021). Available Chemical Constituents and Activities of Ganoderma Lucidum (Lingzhi or Red Reishi) Utilizing in Disease Treatment: A mini review. Journal of Research in Clinical Medicine. 9. 10.34172/jrcm.2021.032.
https://jrcm.tbzmed.ac.ir/Article/jrcm-31996
5. Ren ZL, Wang CD, Wang T, et al. Ganoderma lucidum extract ameliorates MPTP-induced parkinsonism and protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis. Acta Pharmacologica Sinica. 2019 Apr;40(4):441-450. DOI: 10.1038/s41401-018-0077-8. PMID: 29991712; PMCID: PMC6461997.
https://europepmc.org/article/MED/29991712
6. Poewe W, Seppi K, Tanner CM, et al. Parkinson disease. Nature reviews. Disease Primers. 2017 Mar;3:17013. DOI: 10.1038/nrdp.2017.13. PMID: 28332488.
http://europepmc.org/article/MED/28332488
7. Simon DK, Tanner CM, Brundin P. Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology. Clinics in Geriatric Medicine. 2020 Feb;36(1):1-12. DOI: 10.1016/j.cger.2019.08.002. PMID: 31733690; PMCID: PMC6905381.
https://europepmc.org/article/PMC/6905381
8. Kuypers KPC. Self-Medication with <i>Ganoderma lucidum</i> ("Reishi") to Combat Parkinson's Disease Symptoms: A Single Case Study. Journal of Medicinal Food. 2021 Jul;24(7):766-773. DOI: 10.1089/jmf.2020.0137. PMID: 33170078; PMCID: PMC8311956.
https://europepmc.org/article/MED/33170078
9. Qin Z, Zhang L, Sun F, Liu H, Fang X, Chan P; Chinese Parkinson Study Group. Depressive symptoms impacting on health-related quality of life in early Parkinson's disease: results from Chinese L-dopa exposed cohort. Clin Neurol Neurosurg. 2009 Nov;111(9):733-7. doi: 10.1016/j.clineuro.2009.07.001. Epub 2009 Aug 8. PMID: 19665835.
https://pubmed.ncbi.nlm.nih.gov/19665835/
10. Hemmerle AM, Herman JP, Seroogy KB. Stress, depression and Parkinson's disease. Experimental Neurology. 2012 Jan;233(1):79-86. DOI: 10.1016/j.expneurol.2011.09.035. PMID: 22001159; PMCID: PMC3268878.
https://europepmc.org/article/PMC/3268878
11. Phan CW, David P, Naidu M, Wong KH, Sabaratnam V. Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism. Crit Rev Biotechnol. 2015;35(3):355-68. doi: 10.3109/07388551.2014.887649. PMID: 24654802.
https://pubmed.ncbi.nlm.nih.gov/24654802/
12. Guo SS, Cui XL, Rausch WD. Ganoderma Lucidum polysaccharides protect against MPP(+) and rotenone-induced apoptosis in primary dopaminergic cell cultures through inhibiting oxidative stress. American Journal of Neurodegenerative Disease. 2016 ;5(2):131-144. PMID: 27335703; PMCID: PMC4913221.
https://europepmc.org/article/MED/27335703
13. Zhang R, Xu S, Cai Y, et al. Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation. Evidence-based Complementary and Alternative Medicine : Ecam. 2011 ;2011:156810. DOI: 10.1093/ecam/nep075. PMID: 19617199; PMCID: PMC3136196.
https://europepmc.org/article/MED/19617199
14. Gill BS, Kumar S, Navgeet. Ganoderic acid targeting nuclear factor erythroid 2-related factor 2 in lung cancer. Tumour Biol. 2017 Mar;39(3):1010428317695530. doi: 10.1177/1010428317695530. PMID: 28349780.
https://pubmed.ncbi.nlm.nih.gov/28349780/
15. Ganji F, Barari A, Abdi A. Effects of Ganoderma Extraction and Eight-Week Endurance Exercises on Plasma Values Neurotrophic Factors Based on Brain and Nerve Growth in Men with Parkinson's. RJMS 2021; 27 (12) :120-130
https://rjms.iums.ac.ir/article-1-6505-en.html
16. Zhang R, Xu S, Cai Y, et al. Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation. Evidence-based Complementary and Alternative Medicine : Ecam. 2011 ;2011:156810. DOI: 10.1093/ecam/nep075. PMID: 19617199; PMCID: PMC3136196.
https://europepmc.org/article/MED/19617199
17. Zhang R, Xu S, Cai Y, et al. Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation. Evidence-based Complementary and Alternative Medicine : Ecam. 2011 ;2011:156810. DOI: 10.1093/ecam/nep075. PMID: 19617199; PMCID: PMC3136196.
https://pubmed.ncbi.nlm.nih.gov/21170502/
18. McFarthing K, Rafaloff G, Baptista M, et al. Parkinson's Disease Drug Therapies in the Clinical Trial Pipeline: 2022 Update. Journal of Parkinson's Disease. 2022 ;12(4):1073-1082. DOI: 10.3233/jpd-229002. PMID: 35527571; PMCID: PMC9198738.
https://europepmc.org/article/pmc/pmc9198738
19. Effects of Lingzhi on Disease Progression in Patients With Untreated Early Parkinson's Disease, ClinicalTrials.gov.
https://clinicaltrials.gov/ct2/show/record/NCT03594656?view=record
20. Sung YF, Yin JH, Lee KH, Tsai CL, Lin YK, Chen SY, Chung CH, Chien WC, Lee JT, Chou CH. Increased risk of sleep-related movement disorder in patients with Helicobacter pylori infection: A nationwide population-based study. Front Neurol. 2022 Oct 10;13:953821. doi: 10.3389/fneur.2022.953821. PMID: 36299273; PMCID: PMC9589275.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589275/
21. Wei BR, Zhao YJ, Cheng YF, Huang C, Zhang F. Helicobacter pylori infection and Parkinson's Disease: etiology, pathogenesis and levodopa bioavailability. Immun Ageing. 2024 Jan 2;21(1):1. doi: 10.1186/s12979-023-00404-1. PMID: 38166953; PMCID: PMC10759355.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10759355/
22. Rothenbacher D, Bode G, Peschke F, Berg G, Adler G, Brenner H. Active infection with Helicobacter pylori in an asymptomatic population of middle aged to elderly people. Epidemiol Infect. 1998 Jun;120(3):297-303. doi: 10.1017/s0950268898008644. PMID: 9692608; PMCID: PMC2809407.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809407/
23. Graham DY, Malaty HM, Evans DG, Evans DJ Jr, Klein PD, Adam E. Epidemiology of Helicobacter pylori in an asymptomatic population in the United States. Effect of age, race, and socioeconomic status. Gastroenterology. 1991 Jun;100(6):1495-501. doi: 10.1016/0016-5085(91)90644-z. PMID: 2019355.
https://pubmed.ncbi.nlm.nih.gov/2019355/
24. Epidemiology of, and risk factors for, Helicobacter pylori infection among 3194 asymptomatic subjects in 17 populations. The EUROGAST Study Group. Gut. 1993 Dec;34(12):1672-6. doi: 10.1136/gut.34.12.1672. PMID: 8282253; PMCID: PMC1374460.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1374460/
Ε1. International Journal of Medicinal Mushrooms Volume 17, 2015 Issue 11 Lion's Mane, Hericium erinaceus and Tiger Milk, Lignosus rhinocerotis (Higher Basidiomycetes) Medicinal Mushrooms Stimulate Neurite Outgrowth in Dissociated Cells of Brain, Spinal Cord, and Retina: An In Vitro Study
https://www.dl.begellhouse.com/journals/708ae68d64b17c52,343363596ed9bda8,45484d446fc46878.html
Ε2. I-Chen Li, Li-Ya Lee, Tsai-Teng Tzeng, Wan-Ping Chen, Yen-Po Chen, Young-Ju Shiao, Chin-Chu Chen, "Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines", Behavioural Neurology, vol. 2018, Article ID 5802634, 10 pages, 2018. https://doi.org/10.1155/2018/5802634
https://www.hindawi.com/journals/bn/2018/5802634/
Ε3. Kuo, HC., Lu, CC., Shen, CH. et al. RETRACTED ARTICLE: Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade. J Transl Med 14, 78 (2016). https://doi.org/10.1186/s12967-016-0831-y
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0831-y
Ε4. Biology, cultivation, and medicinal functions of the mushroom Hericium erinaceum Sławomir Sokół, Iwona Golak-Siwulska, Krzysztof Sobieralski, Marek Siwulski, Katarzyna Górka
https://pbsociety.org.pl/journals/index.php/am/article/view/am.1069
Ε5. He X, Wang X, Fang J, Chang Y, Ning N, Guo H, Huang L, Huang X, Zhao Z. Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion's Mane) mushroom: A review. Int J Biol Macromol. 2017 Apr;97:228-237. doi: 10.1016/j.ijbiomac.2017.01.040. Epub 2017 Jan 10. PMID: 28087447.
https://pubmed.ncbi.nlm.nih.gov/28087447/
Ε6. Cheng JH, Tsai CL, Lien YY, Lee MS, Sheu SC. High molecular weight of polysaccharides from Hericium erinaceus against amyloid beta-induced neurotoxicity. BMC Complementary and Alternative Medicine. 2016 Jun;16:170. DOI: 10.1186/s12906-016-1154-5. PMID: 27266872; PMCID: PMC4895996.
https://europepmc.org/article/MED/27266872
Ε7. Yang, Pao-Pao & CY, Lin & TY, Lin & WC, Chiang. (2020). Hericium erinaceus Mycelium Exerts Neuroprotective Effect in Parkinson’s Disease-in vitro and in vivo Models. Journal of Drug Research and Development. 6. 10.16966/2470-1009.150.
https://www.researchgate.net/publication/342205958_Hericium_erinaceus_Mycelium_Exerts_Neuroprotective_Effect_in_Parkinson%27s_Disease-in_vitro_and_in_vivo_Models
Ε8. Brandalise F, Roda E, Ratto D, Goppa L, Gargano ML, Cirlincione F, Priori EC, Venuti MT, Pastorelli E, Savino E, et al. Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline? Journal of Fungi. 2023; 9(5):551. https://doi.org/10.3390/jof9050551
https://www.mdpi.com/2309-608X/9/5/551
Ε9. Huang, HT., Ho, CH., Sung, HY. et al. Hericium erinaceus mycelium and its small bioactive compounds promote oligodendrocyte maturation with an increase in myelin basic protein. Sci Rep 11, 6551 (2021). https://doi.org/10.1038/s41598-021-85972-2
https://www.nature.com/articles/s41598-021-85972-2
Ε10. The Effect of Hericium Erinaceus Mycelium in Non-motor Symptoms of Parkinson's Disease ClinicalTrials.gov ID NCT04428983 Sponsor National Cheng-Kung University Hospital Information provided by Yuan-Ting Sun, National Cheng-Kung University Hospital (Responsible Party) Last Update Posted 2020-06-11
https://clinicaltrials.gov/study/NCT04428983
Ε11. Li IC, Chang HH, Lin CH, Chen WP, Lu TH, Lee LY, Chen YW, Chen YP, Chen CC, Lin DP. Prevention of Early Alzheimer's Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study. Front Aging Neurosci. 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PMID: 32581767; PMCID: PMC7283924.
https://www.frontiersin.org/articles/10.3389/fnagi.2020.00155/full
Ε12. Biologically Functional Compounds From Mushroom-Forming Fungi Hirokazu Kawagishi, in Natural Products and Drug Discovery, 2018
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/hericium-erinaceus
224. Sachchida Nand Rai, Divya Mishra, Payal Singh, Emanuel Vamanu, M.P. Singh, Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases, Biomedicine & Pharmacotherapy, Volume 137, 2021, 111377, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2021.111377.
https://www.sciencedirect.com/science/article/pii/S0753332221001621
225. Phan CW, David P, Naidu M, Wong KH, Sabaratnam V. Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism. Crit Rev Biotechnol. 2015;35(3):355-68. doi: 10.3109/07388551.2014.887649. PMID: 24654802.
https://pubmed.ncbi.nlm.nih.gov/24654802/
Γαστροοισοφαγική παλινδρόμηση
671. Azer SA, Hashmi MF, Reddivari AKR. Gastroesophageal Reflux Disease (GERD) [Updated 2024 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK554462/
672. Shaqran TM, Ismaeel MM, Alnuaman AA, Al Ahmad FA, Albalawi GA, Almubarak JN, AlHarbi RS, Alaqidi RS, AlAli YA, Alfawaz KS, Daghriri AA. Epidemiology, Causes, and Management of Gastro-esophageal Reflux Disease: A Systematic Review. Cureus. 2023 Oct 21;15(10):e47420. doi: 10.7759/cureus.47420. PMID: 38022211; PMCID: PMC10658748.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10658748/
673. Nirwan, J.S., Hasan, S.S., Babar, ZUD. et al. Global Prevalence and Risk Factors of Gastro-oesophageal Reflux Disease (GORD): Systematic Review with Meta-analysis. Sci Rep 10, 5814 (2020). https://doi.org/10.1038/s41598-020-62795-1
https://www.nature.com/articles/s41598-020-62795-1
674. Baklola, M., Terra, M., Badr, A. et al. Prevalence of gastro-oesophageal reflux disease, and its associated risk factors among medical students: a nation-based cross-sectional study. BMC Gastroenterol 23, 269 (2023). https://doi.org/10.1186/s12876-023-02899-w
https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-023-02899-w
675. Zhang D, Liu S, Li Z, Wang R. Global, regional and national burden of gastroesophageal reflux disease, 1990-2019: update from the GBD 2019 study. Ann Med. 2022 Dec;54(1):1372-1384. doi: 10.1080/07853890.2022.2074535. PMID: 35579516; PMCID: PMC9122392.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9122392/
676. Eivind Ness-Jensen, Jesper Lagergren, Tobacco smoking, alcohol consumption and gastro-oesophageal reflux disease, Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 5, 2017, Pages 501-508, ISSN 1521-6918, https://doi.org/10.1016/j.bpg.2017.09.004.
https://www.sciencedirect.com/science/article/abs/pii/S1521691817300999
677. Yen P-C, Geng J-H, Wu P-Y, Huang J-C, Hu H-M, Kuo C-H and Chen S-C (2024) Secondhand smoke is associated with peptic ulcer disease and gastroesophageal reflux disease in non-smokers in a large Taiwanese population study. Front. Public Health. 12:1450481. doi: 10.3389/fpubh.2024.1450481
https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1450481/full
678. Gomm W, von Holt K, Thomé F, et al. Association of Proton Pump Inhibitors With Risk of Dementia: A Pharmacoepidemiological Claims Data Analysis. JAMA Neurol. 2016;73(4):410–416. doi:10.1001/jamaneurol.2015.4791
https://jamanetwork.com/journals/jamaneurology/fullarticle/2487379
679. Ortiz-Guerrero G, Amador-Muñoz D, Calderón-Ospina CA, López-Fuentes D, Nava Mesa MO. Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences. Neural Plast. 2018 Mar 21;2018:5257285. doi: 10.1155/2018/5257285. PMID: 29755512; PMCID: PMC5883984.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5883984/
680. Northuis CA, Bell EJ, Lutsey PL, George KM, Gottesman RF, Mosley TH, Whitsel EA, Lakshminarayan K. Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study. Neurology. 2023 Oct 31;101(18):e1771-e1778. doi: 10.1212/WNL.0000000000207747. Epub 2023 Aug 9. Erratum in: Neurology. 2024 Jul 9;103(1):e209596. doi: 10.1212/WNL.0000000000209596. PMID: 37558503; PMCID: PMC10634644.
https://www.neurology.org/doi/10.1212/WNL.0000000000207747
681. Common questions about esomeprazole, 7 January 2022 NHS of UK
https://www.nhs.uk/medicines/esomeprazole/common-questions-about-esomeprazole/
682. Published July 19, 2017 GASTROENTEROLOGY Proton Pump Inhibitors: Considerations With Long-Term Use, Emily M. Ambizas, PharmD, MPH, BCGP, Joseph V. Etzel, PharmD
https://www.uspharmacist.com/article/proton-pump-inhibitors-considerations-with-longterm-use
683. Maideen NMP. Adverse Effects Associated with Long-Term Use of Proton Pump Inhibitors. Chonnam Med J. 2023 May;59(2):115-127. doi: 10.4068/cmj.2023.59.2.115. Epub 2023 May 25. PMID: 37303818; PMCID: PMC10248387.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10248387/
Εμμηνόπαυση
1. Vikram Talaulikar, Menopause transition: Physiology and symptoms, Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 81, 2022, Pages 3-7, ISSN 1521-6934, https://doi.org/10.1016/j.bpobgyn.2022.03.003.
https://www.sciencedirect.com/science/article/abs/pii/S1521693422000426,
2. Jeong HG, Park H. Metabolic Disorders in Menopause. Metabolites. 2022 Oct 8;12(10):954. doi: 10.3390/metabo12100954. PMID: 36295856; PMCID: PMC9606939.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9606939/
3. Peacock K, Carlson K, Ketvertis KM. Menopause. [Updated 2023 Dec 21]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK507826/
4. Menopause 16 October 2024, WHO
https://www.who.int/news-room/fact-sheets/detail/menopause
5. Medicinal Mushrooms (PDQ®)–Patient Version, July 11, 2024, National Cancer Institute at the National Institutes of Health
https://www.cancer.gov/about-cancer/treatment/cam/patient/mushrooms-pdq
6. Yoshimoto, H.; Miyazawa, N.; Eguchi, F. Wild and Cultivated Mushrooms Exhibit Anti-Inflammatory Effects Including Inhibition of Platelet Aggregation and Interleukin-8 Expression. Appl. Microbiol. 2025, 5, 36. https://doi.org/10.3390/applmicrobiol5020036
https://www.mdpi.com/2673-8007/5/2/36
7. Wasser SP. Medicinal Mushrooms in Human Clinical Studies. Part I. Anticancer, Oncoimmunological, and Immunomodulatory Activities: A Review. Int J Med Mushrooms. 2017;19(4):279-317. doi: 10.1615/IntJMedMushrooms.v19.i4.10. PMID: 28605319.
https://pubmed.ncbi.nlm.nih.gov/28605319/
8. International Journal of Medicinal Mushrooms Editor-in-Chief: Solomon P. Wasser
https://www.begellhouse.com/journals/medicinal-mushrooms.html
9. Meade E, Hehir S, Rowan N, Garvey M. Mycotherapy: Potential of Fungal Bioactives for the Treatment of Mental Health Disorders and Morbidities of Chronic Pain. J Fungi (Basel). 2022 Mar 11;8(3):290. doi: 10.3390/jof8030290. PMID: 35330292; PMCID: PMC8954642.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8954642/
10. Conde DM, Verdade RC, Valadares ALR, Mella LFB, Pedro AO, Costa-Paiva L. Menopause and cognitive impairment: A narrative review of current knowledge. World J Psychiatry. 2021 Aug 19;11(8):412-428. doi: 10.5498/wjp.v11.i8.412. PMID: 34513605; PMCID: PMC8394691.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8394691/
11. Maki PM, Jaff NG. Menopause and brain fog: how to counsel and treat midlife women. Menopause. 2024 Jul 1;31(7):647-649. doi: 10.1097/GME.0000000000002382. Epub 2024 Jun 17. PMID: 38888619.
https://pubmed.ncbi.nlm.nih.gov/38888619/
12. Menopause and brain fog: What’s the link? Research ties severity of certain menopause symptoms to cognitive performance. June 1, 2022 By Maureen Salamon, Executive Editor, Harvard Women’s Health Watch
https://www.health.harvard.edu/womens-health/menopause-and-brain-fog-whats-the-link
13. Sabaratnam V, Kah-Hui W, Naidu M, Rosie David P. Neuronal health – can culinary and medicinal mushrooms help? J Tradit Complement Med. 2013 Jan;3(1):62-8. doi: 10.4103/2225-4110.106549. PMID: 24716157; PMCID: PMC3924982.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3924982/
14. Sara Cha, Lynne Bell, Barbara Shukitt-Hale, Claire M. Williams, A review of the effects of mushrooms on mood and neurocognitive health across the lifespan, Neuroscience & Biobehavioral Reviews, Volume 158, 2024, 105548, ISSN 0149-7634, https://doi.org/10.1016/j.neubiorev.2024.105548.
https://www.sciencedirect.com/science/article/pii/S0149763424000162
15. Ban, S.; Do, T.T.; Pyo, J.-W.; Moon, M.; Park, J.-T. INO10, a Chaga Mushroom Extract, Alleviates Alzheimer’s Disease-Related Pathology and Cognitive Deficits in 3xTg-AD Mice. Int. J. Mol. Sci. 2025, 26, 4729. https://doi.org/10.3390/ijms26104729
https://www.mdpi.com/1422-0067/26/10/4729
16. Benjarong Thongbai, Sylvie Rapior, Kevin Hyde, Kathrin Wittstein, Marc Stadler. Hericium erinaceus, an amazing medicinal mushroom. Mycological Progress, 2015, 14 (10), pp.91, doi:10.1007/s11557-015-1105-4. 10.1007/s11557-015-1105-4. hal-02196151
https://hal.umontpellier.fr/hal-02196151v1/document
17. News Mushrooms magnify memory by boosting nerve growth 10 February 2023, The University of Queensland
https://news.uq.edu.au/2023-02-10-mushrooms-magnify-memory-boosting-nerve-growth
18. Are Mushroom Supplements the Key to Boosting Your Brain Health? More research is needed, but they may be worth a try, LaKeisha Fleming, February 04, 2025, Medically reviewed by Steven Gans, MD, Verywell Mind
https://www.verywellmind.com/mushroom-supplements-for-brain-health-8784675
19. Martínez-Mármol, R., Chai, Y., Conroy, J. N., Khan, Z., Hong, S.-M., Kim, S. B., Gormal, R. S., Lee, D. H., Lee, J. K., Coulson, E. J., Lee, M. K., Kim, S. Y., & Meunier, F. A. (2023). Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory. Journal of Neurochemistry, 165, 791–808. https://doi.org/10.1111/jnc.15767
https://onlinelibrary.wiley.com/doi/10.1111/jnc.15767
20. Oliwia Koszła, Wirginia Kukula-Koch, Krzysztof Jóźwiak, Rafał Jastrząb, Małgorzata Anna Marć, Jennifer Mytych, Anna Tabęcka-Łonczyńska, Bartosz Skóra, Konrad A. Szychowski, Przemysław Sołek, Biotransformation of Ganoderma lucidum and Hericium erinaceus for ex vivo gut-brain axis modulation and mood-related outcomes in humans: CREB/BDNF signaling and microbiota-driven synergies, Journal of Ethnopharmacology, Volume 342, 2025, 119393, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2025.119393.
https://www.sciencedirect.com/science/article/abs/pii/S0378874125000765
21. Contato, A.G.; Conte-Junior, C.A. Lion’s Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential—A Narrative Review. Nutrients 2025, 17, 1307. https://doi.org/10.3390/nu17081307
https://www.mdpi.com/2072-6643/17/8/1307
22. Shaik, Aminabee & Dasari, Santhi & Shankar, Kunderu Ravi & Manasa, G. & Manikanta, Siram & Nirmala, Nalam & Chandrika, Lingineni & Karthik, Siddineni & Evangel, Nakka. (2025). Exploring the Neuroprotective Potential of Functional Mushrooms: A Comprehensive Review. Journal of Natural Remedies. 1299-1308. 10.18311/jnr/2025/49048.
https://www.researchgate.net/publication/393287089_Exploring_the_Neuroprotective_Potential_of_Functional_Mushrooms_A_Comprehensive_Review
23. Martínez-Mármol, R., Chai, Y., Conroy, J. N., Khan, Z., Hong, S.-M., Kim, S. B., Gormal, R. S., Lee, D. H., Lee, J. K., Coulson, E. J., Lee, M. K., Kim, S. Y., & Meunier, F. A. (2023). Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory. Journal of Neurochemistry, 165, 791–808. https://doi.org/10.1111/jnc.15767
https://onlinelibrary.wiley.com/doi/10.1111/jnc.15767
24. Xu-Jia Chen, Zhou Deng, Le-Le Zhang, Yan Pan, Jia Fu, Liang Zou, Zhaofang Bai, Xiaohe Xiao, Feiya Sheng, Therapeutic potential of the medicinal mushroom Ganoderma lucidum against Alzheimer’s disease, Biomedicine & Pharmacotherapy, Volume 172, 2024, 116222, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2024.116222.
https://www.sciencedirect.com/science/article/pii/S0753332224001033
25. Menon A, Jalal A, Arshad Z, Nawaz FA and Kashyap R (2025) Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review. Front. Nutr. 12:1641246. doi: 10.3389/fnut.2025.1641246
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1641246/full
26. Szućko-Kociuba I, Trzeciak-Ryczek A, Kupnicka P, Chlubek D. Neurotrophic and Neuroprotective Effects of Hericium erinaceus. Int J Mol Sci. 2023 Nov 3;24(21):15960. doi: 10.3390/ijms242115960. PMID: 37958943; PMCID: PMC10650066.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10650066/
27. Sachchida Nand Rai, Divya Mishra, Payal Singh, Emanuel Vamanu, M.P. Singh, Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases, Biomedicine & Pharmacotherapy, Volume 137, 2021, 111377, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2021.111377.
https://www.sciencedirect.com/science/article/pii/S0753332221001621
28. Lai PL, Naidu M, Sabaratnam V, Wong KH, David RP, Kuppusamy UR, Abdullah N, Malek SN. Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms. 2013;15(6):539-54. doi: 10.1615/intjmedmushr.v15.i6.30. PMID: 24266378.
https://pubmed.ncbi.nlm.nih.gov/24266378/
29. Hericerin derivatives from Hericium erinaceus exert BDNF-like neurotrophic activity in central hippocampal neurons and enhance memory Ramón Martínez-Mármol, YeJin Chai, Zahra Khan, Seon Beom Kim, Seong Min Hong, Rachel S. Gormal, Dae Hee Lee, Jae Kang Lee, Mi Kyeong Lee, Sun Yeou Kim, Frédéric A. Meunier bioRxiv 2020.08.28.271676; doi: https://doi.org/10.1101/2020.08.28.271676
https://www.biorxiv.org/content/10.1101/2020.08.28.271676v1.full
30. Bell V, Dimitrov P, Fernandes T. Supporting Neurologic Health with Mushroom Nutrition. Nutrients. 2025 May 2;17(9):1568. doi: 10.3390/nu17091568. PMID: 40362877; PMCID: PMC12073738.
https://www.mdpi.com/2072-6643/17/9/1568
31. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009 Mar;23(3):367-72. doi: 10.1002/ptr.2634. PMID: 18844328.
https://pubmed.ncbi.nlm.nih.gov/18844328/
32. Li IC, Chang HH, Lin CH, et al. Prevention of Early Alzheimer’s Disease by Erinacine A-Enriched <i>Hericium erinaceus</i> Mycelia Pilot Double-Blind Placebo-Controlled Study. Frontiers in Aging Neuroscience. 2020;12:155. DOI: 10.3389/fnagi.2020.00155. PMID: 32581767; PMCID: PMC7283924.
https://europepmc.org/article/MED/32581767
33. Li IC, Lee LY, Tzeng TT, Chen WP, Chen YP, Shiao YJ, Chen CC. Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines. Behav Neurol. 2018 May 21;2018:5802634. doi: 10.1155/2018/5802634. PMID: 29951133; PMCID: PMC5987239.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987239/
34. Saitsu Y, Nishide A, Kikushima K, Shimizu K, Ohnuki K. Improvement of cognitive functions by oral intake of Hericium erinaceus. Biomed Res. 2019;40(4):125-131. doi: 10.2220/biomedres.40.125. PMID: 31413233.
https://pubmed.ncbi.nlm.nih.gov/31413233/
35. La Monica MB, Raub B, Ziegenfuss EJ, Hartshorn S, Grdic J, Gustat A, Sandrock J, Ziegenfuss TN. Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion’s Mane Extracts on Cognitive Performance. Nutrients. 2023 Dec 6;15(24):5018. doi: 10.3390/nu15245018. PMID: 38140277; PMCID: PMC10745489.
https://pubmed.ncbi.nlm.nih.gov/38140277/
https://www.mdpi.com/2072-6643/15/24/5018
36. The reality of menopause weight gain Many women gain weight as they age, but extra pounds aren’t inevitable. To help ease weight gain, step up your activity level and enjoy a healthy diet. Mayo Clinic Staff, July 08, 2023
https://www.mayoclinic.org/healthy-lifestyle/womens-health/in-depth/menopause-weight-gain/art-20046058
37. Ann R. Lurati, Effects of Menopause on Appetite and the Gastrointestinal System, Nursing for Women’s Health, Volume 22, Issue 6, 2018, Pages 499-505, ISSN 1751-4851, https://doi.org/10.1016/j.nwh.2018.09.004.
https://www.sciencedirect.com/science/article/abs/pii/S1751485118301983
38. Review Role of Ghrelin in Postmenopausal obesity Mona Mohamed Ibrahim Abdalla1,2, Ravindran Jegasothy2 1Human Biology Department, School of Medicine, International Medical University, Malaysia 2Faculty of Medicine, MAHSA University, Malaysia IJWHR 2020; 8: 119-124 DOI: 10.15296/ijwhr.2020.19
https://www.ijwhr.net/text.php?id=448
39. Precious U. Ezurike, Evelyn Odunola, Tolulope A. Oke, Adewale G. Bakre, Oluwayimika Olumide, OgoOluwa Odetoye, Adenike M. Alege, Oyindamola O. Abiodun, Ganoderma lucidum ethanol extract promotes weight loss and improves depressive-like behaviors in male and female Swiss mice, Physiology & Behavior, Volume 265, 2023, 114155, ISSN 0031-9384, https://doi.org/10.1016/j.physbeh.2023.114155.
https://www.sciencedirect.com/science/article/abs/pii/S0031938423000835
40. Eshita Sharma, Rakesh Bairwa, Priyanka Lal, Sudeepta Pattanayak, Kota Chakrapani, Rajendra Poorvasandhya, Awadhesh Kumar, Muhammad Ahsan Altaf, Rahul Kumar Tiwari, Milan Kumar Lal, Ravinder Kumar, Edible mushrooms trending in food: Nutrigenomics, bibliometric, from bench to valuable applications, Heliyon, Volume 10, Issue 17, 2024, e36963, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2024.e36963.
https://www.sciencedirect.com/science/article/pii/S2405844024129945
41. Ganesan K, Xu B. Anti-Obesity Effects of Medicinal and Edible Mushrooms. Molecules. 2018 Nov 5;23(11):2880. doi: 10.3390/molecules23112880. PMID: 30400600; PMCID: PMC6278646.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6278646/
42. Holmes, D. Medicinal mushroom reduces obesity by modulating microbiota. Nat Rev Endocrinol 11, 504 (2015). https://doi.org/10.1038/nrendo.2015.114
https://www.nature.com/articles/nrendo.2015.114
43. Alvandi, H., Ansari, E. ., Kianirad, S. ., Hatamian-Zarmi, A., Mokhtari Hosseini, Z. B., & Ebrahimi-Hosseinzadeh, B. (2022). Medicinal mushrooms as potential therapeutic agents in the treatment of diabetes mellitus: a review with focusing on in vivo and clinical studies. Italian Journal of Mycology, 51(1), 75–96. https://doi.org/10.6092/issn.2531-7342/15023
https://italianmycology.unibo.it/article/view/15023
44. Mushroom coffee: Worth a taste? June 4, 2024 By Lindsay Warner, Content Licensing Editor, Harvard Health Publishing
https://www.health.harvard.edu/nutrition/mushroom-coffee-worth-a-taste
45. Łysakowska P, Sobota A, Wirkijowska A. Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review. Molecules. 2023 Jul 14;28(14):5393. doi: 10.3390/molecules28145393. PMID: 37513265; PMCID: PMC10384337.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10384337/
46. Volume 1, Issue 2 (November 2022), Health Science Monitor 2022, 1(2): 107-108 Does Ganoderma lucidum reduce obesity? Ameneh Marzban , Abdolrazagh Marzban , Payam Emami * Department of Emergency Medical Sciences, School of Paramedical Sciences, Kurdistan University of Medical Sciences, Sanandaj, Iran
https://hsm.umsu.ac.ir/browse.php?a_id=46&sid=1&slc_lang=en
47. Stamatia-Angeliki Kleftaki, Stamatia Simati, Charalampia Amerikanou, Aristea Gioxari, Chara Tzavara, Georgios I. Zervakis, Nick Kalogeropoulos, Alexander Kokkinos, Andriana C. Kaliora, Pleurotus eryngii improves postprandial glycaemia, hunger and fullness perception, and enhances ghrelin suppression in people with metabolically unhealthy obesity, Pharmacological Research, Volume 175, 2022, 105979, ISSN 1043-6618, https://doi.org/10.1016/j.phrs.2021.105979.
https://www.sciencedirect.com/science/article/abs/pii/S1043661821005636
48. Son EH, Jung DH, Shin H, Lee S, Kim Y, Lim HS. Effects of the Intestinal Status and Clinical Factors of Korean Middle-Aged People Through the Consumption of Functional Foods Containing Auricularia auricula-judae Powder: Prospective, Randomized, Open-Label, and Control Comparative Trial. Clin Nutr Res. 2025 Jan 22;14(1):7-16. doi: 10.7762/cnr.2025.14.1.7. PMID: 39968271; PMCID: PMC11832288.
https://pubmed.ncbi.nlm.nih.gov/39968271/
49. Mendes LC. Effective fuling (Poria Cocos) for the treatment of obesity? Int J Complement Alt Med. 2018;11(6):380-385. DOI: 10.15406/ijcam.2018.11.00430
https://medcraveonline.com/IJCAM/effective-fuling-poria-cocos-for-the-treatment-of-obesity.html
https://www.researchgate.net/publication/329950997_Effective_fuling_Poria_Cocos_for_the_treatment_of_obesity
51. How Can Menopause Affect Sleep Updated January 18, 2024 Lucy Bryan Contributing Writer Lucy Bryan Alyssa Dweck, MD, FACOG Medically Reviewed by Alyssa Dweck, MD, FACOG
https://www.sleepfoundation.org/women-sleep/menopause-and-sleep
52. Maki PM, Panay N, Simon JA. Sleep disturbance associated with the menopause. Menopause. 2024 Aug 1;31(8):724-733. doi: 10.1097/GME.0000000000002386. Epub 2024 Jun 25. PMID: 38916279.
https://pubmed.ncbi.nlm.nih.gov/38916279/
53. Qiu Y, Mao ZJ, Ruan YP, Zhang X. Exploration of the anti-insomnia mechanism of Ganoderma by central-peripheral multi-level interaction network analysis. BMC Microbiol. 2021 Oct 29;21(1):296. doi: 10.1186/s12866-021-02361-5. PMID: 34715778; PMCID: PMC8555286.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555286/
54. Wei Chen, Jun-Wen Yu, Yu-Yi Deng, Lut Yi Wong, Chen Wang, Yu-Ling Liang, Yuk-Tung Leung, Jia-Yi Tian, Ying Wu, Kelvin Sze-Yin Leung, Jinhui Hu, Wen-Hua Chen, Xiaobing Dou, Xiu-Qiong Fu, Ying-Jie Chen, Zhi-Ling Yu, Identification of sedative-hypnotic compounds shared by five medicinal Polyporales mushrooms using UPLC-Q-TOF-MS/MS-based untargeted metabolomics, Phytomedicine, Volume 128, 2024, 155355, ISSN 0944-7113, https://doi.org/10.1016/j.phymed.2024.155355.
https://www.sciencedirect.com/science/article/abs/pii/S0944711324000205
55. Tselepis, George & Palamiotis, Ioannis & Georgiou, Sofia. (2023). Homeostasis of Circadian Rhythm and Therapeutic Approaches to Manage its Related-Disorders: The Case of Medicinal Mushrooms Rich in Melatonin. Med Discoveries. 2. 10.52768/2993-1142/1075.
https://www.researchgate.net/publication/375439212_Homeostasis_of_Circadian_Rhythm_and_Therapeutic_Approaches_to_Manage_its_Related-Disorders_The_Case_of_Medicinal_Mushrooms_Rich_in_Melatonin
56. Kim H, Choi H, Park BG, Ju HJ, Kim YI. Efficacy of Poria Cocos Extract on Sleep Quality Enhancement: A Clinical Perspective with Implications for Functional Foods. Nutrients. 2023 Oct 1;15(19):4242. doi: 10.3390/nu15194242. PMID: 37836526; PMCID: PMC10574255.
https://pubmed.ncbi.nlm.nih.gov/37836526/
57. Qiu Y, Mao ZJ, Ruan YP, Zhang X. Exploration of the anti-insomnia mechanism of Ganoderma by central-peripheral multi-level interaction network analysis. BMC Microbiol. 2021 Oct 29;21(1):296. doi: 10.1186/s12866-021-02361-5. PMID: 34715778; PMCID: PMC8555286.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555286/
58. Vigna L, Morelli F, Agnelli GM, et al. <i>Hericium erinaceus</i> Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? Evidence-based Complementary and Alternative Medicine : Ecam. 2019 ;2019:7861297. DOI: 10.1155/2019/7861297. PMID: 31118969; PMCID: PMC6500611.
https://europepmc.org/article/MED/31118969
59. Brandalise F, Roda E, Ratto D, Goppa L, Gargano ML, Cirlincione F, Priori EC, Venuti MT, Pastorelli E, Savino E, Rossi P. Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline? J Fungi (Basel). 2023 May 10;9(5):551. doi: 10.3390/jof9050551. PMID: 37233262; PMCID: PMC10218917.
https://pubmed.ncbi.nlm.nih.gov/37233262/
60. Okamura, Hisayoshi & Anno, Nobuko & Tsuda, Akira & Inokuchi, Takahiro & Uchimura, Naohisa & Inanaga, Kazutoyo. (2015). The effects of Hericium erinaceus (Amyloban® 3399) on sleep quality and subjective well-being among female undergraduate students: A pilot study. Personalized Medicine Universe. 4. 10.1016/j.pmu.2015.03.006.
https://www.researchgate.net/publication/276152143_The_effects_of_Hericium_erinaceus_AmylobanR_3399_on_sleep_quality_and_subjective_well-being_among_female_undergraduate_students_A_pilot_study
61. Exploring the Uses of the Top Medicinal Mushrooms, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Tarikh Input: 22/02/2023 | Kemaskini: 04/04/2023 | aslamiah
https://sgs.upm.edu.my/artikel/exploring_the_uses_of_the_top_medicinal_mushrooms-71534
62. Lu J, Su M, Zhou X, Li D, Niu X, Wang Y. Research Progress of Bioactive Components in Sanghuangporus spp. Molecules. 2024 Mar 7;29(6):1195. doi: 10.3390/molecules29061195. PMID: 38542832; PMCID: PMC10976032.
https://pubmed.ncbi.nlm.nih.gov/38542832/
63. Yao L, Lv J, Duan C, An X, Zhang C, Li D, Li C, Liu S. Armillaria mellea fermentation liquor ameliorates p-chlorophenylalanine-induced insomnia associated with the modulation of serotonergic system and gut microbiota in rats. J Food Biochem. 2022 Feb;46(2):e14075. doi: 10.1111/jfbc.14075. Epub 2022 Jan 5. PMID: 34984694.
https://pubmed.ncbi.nlm.nih.gov/34984694/
64. Sharma H, Sharma N, An SSA. Unique Bioactives from Zombie Fungus (Cordyceps) as Promising Multitargeted Neuroprotective Agents. Nutrients. 2023 Dec 27;16(1):102. doi: 10.3390/nu16010102. PMID: 38201932; PMCID: PMC10780653.
https://pubmed.ncbi.nlm.nih.gov/38201932/
65. Tan YF, Mo JS, Wang YK, Zhang W, Jiang YP, Xu KP, Tan GS, Liu S, Li J, Wang WX. The ethnopharmacology, phytochemistry and pharmacology of the genus Hericium. J Ethnopharmacol. 2024 Jan 30;319(Pt 3):117353. doi: 10.1016/j.jep.2023.117353. Epub 2023 Oct 29. PMID: 37907145.
https://pubmed.ncbi.nlm.nih.gov/37907145/
66. Published April 20, 2009 COMPLEMENTARY and ALTERNATIVE MEDICINE Adaptogenic or Medicinal Mushrooms M. Saljoughian, PharmD, PhD
https://www.uspharmacist.com/article/adaptogenic-or-medicinal-mushrooms
67. Yao, C., Wang, Z., Jiang, H. et al. Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice. Sci Rep 11, 13660 (2021). https://doi.org/10.1038/s41598-021-92913-6
https://www.nature.com/articles/s41598-021-92913-6
68. Batra P, Sharma AK, Khajuria R. Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. Int J Med Mushrooms. 2013;15(2):127-43. doi: 10.1615/intjmedmushr.v15.i2.20. PMID: 23557365.
https://pubmed.ncbi.nlm.nih.gov/23557365/
69. Lee KH, Morris-Natschke SL, Yang X, Huang R, Zhou T, Wu SF, Shi Q, Itokawa H. Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine. J Tradit Complement Med. 2012 Apr;2(2):84-95. PMID: 24716120; PMCID: PMC3942920.
https://core.ac.uk/download/pdf/82062841.pdf
70. Reishi Cultivation The mushroom of immortality, Michael den Herder, European Forest Institute, [email protected] April 2022
https://efi.int/sites/default/files/files/knowledge/projects/EFI_Reishi_Cultivation_EN.pdf
71. Sanodiya BS, Thakur GS, Baghel RK, Prasad GB, Bisen PS. Ganoderma lucidum: a potent pharmacological macrofungus. Curr Pharm Biotechnol. 2009 Dec;10(8):717-42. doi: 10.2174/138920109789978757. PMID: 19939212.
https://pubmed.ncbi.nlm.nih.gov/19939212/
72. Yao C, Wang Z, Jiang H, Yan R, Huang Q, Wang Y, Xie H, Zou Y, Yu Y, Lv L. Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice. Sci Rep. 2021 Jul 1;11(1):13660. doi: 10.1038/s41598-021-92913-6. PMID: 34211003; PMCID: PMC8249598.
https://pubmed.ncbi.nlm.nih.gov/34211003/
73. Jia, Ling-Feng & Chen, Ping & Qu, Gui-Da & Sun, Ning & Guo, Tao & Zhong, Huai-Yu & Duan, Yi-Han & Sun, Jia-Hui & Sun, Jing-Bo. (2025). A comprehensive review of the sedative-hypnotic mechanisms of edible fungi. Food & Medicine Homology. 10.26599/FMH.2025.9420049.
https://www.sciopen.com/article/10.26599/FMH.2025.9420049
https://www.researchgate.net/publication/395136109_A_comprehensive_review_of_the_sedative-hypnotic_mechanisms_of_edible_fungi
74. March 28, 2025/Living Healthy/Women’s Health Can Menopause Cause Anxiety? Cleveland Clinic
https://health.clevelandclinic.org/is-menopause-causing-your-mood-swings-depression-or-anxiety
75. Can Menopause Cause Depression? The Johns Hopkins University
https://www.hopkinsmedicine.org/health/wellness-and-prevention/can-menopause-cause-depression
76. Better Psychological Well-Being Through Menopause, SWAN Study
https://www.swanstudy.org/womens-health-info/better-psychological-well-being-through-menopause/
77. Lazur J, Hnatyk K, Kała K, Sułkowska-Ziaja K, Muszyńska B. Discovering the Potential Mechanisms of Medicinal Mushrooms Antidepressant Activity: A Review. Antioxidants (Basel). 2023 Mar 2;12(3):623. doi: 10.3390/antiox12030623. PMID: 36978872; PMCID: PMC10044934.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10044934/
78. Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, Ohnuki K. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res. 2010 Aug;31(4):231-7. doi: 10.2220/biomedres.31.231. PMID: 20834180.
https://pubmed.ncbi.nlm.nih.gov/20834180
79. Mitra S, Mitra M, Nandi DK, Saha M, Bandyopadhyay A. Efficacy of Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Supplementation on Psychological Stress and Selective Fitness Profile Parameters in Female College Students in West Bengal, India. Int J Med Mushrooms. 2024;26(11):51-64. doi: 10.1615/IntJMedMushrooms.2024055300. PMID: 39241163.
https://pubmed.ncbi.nlm.nih.gov/39241163/
80. Evid Based Complement Alternat Med, 2019, 7861297 2019 Apr 18 eCollection 2019 Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? Luisella Vigna, Federica Morelli, Gianna M Agnelli, Filomena Napolitano, Daniela Ratto, Alessandra Occhinegro, Carmine Di Iorio, Elena Savino, Carolina Girometta, Federico Brandalise, Paola Rossi
https://europepmc.org/article/MED/31118969
81. Kazutoyo Inanaga, Marked improvement of neurocognitive impairment after treatment with compounds from Hericium erinaceum: A case study of recurrent depressive disorder, Personalized Medicine Universe, Volume 3, 2014, Pages 46-48, ISSN 2186-4950, https://doi.org/10.1016/j.pmu.2014.02.004.
https://www.sciencedirect.com/science/article/abs/pii/S2186495014000108?via%3Dihub
82. Limanaqi F, Biagioni F, Busceti CL, Polzella M, Fabrizi C, Fornai F. Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea. Antioxidants (Basel). 2020 Mar 12;9(3):234. doi: 10.3390/antiox9030234. PMID: 32178272; PMCID: PMC7139475.
https://pubmed.ncbi.nlm.nih.gov/32178272/
83. Thyroid and menopause article, British Thyroid Foundation, May 2023
https://www.btf-thyroid.org/thyroid-and-menopause-article
84. Frank-Raue K, Raue F. Thyroid Dysfunction in Periand Postmenopausal Women-Cumulative Risks. Dtsch Arztebl Int. 2023 May 5;120(18):311-316. doi: 10.3238/arztebl.m2023.0069. PMID: 37013812; PMCID: PMC10398375.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10398375/
85. ZHAO Ze-fei, ZHAO Yong-ju, GU Ming-jun, et al. Effect of Ganoderma lucidum polysaccharides on hyperthyroidism and liver injury in Graves´|disease mice model[J]. , 2013, 33(5): 607-.
https://xuebao.shsmu.edu.cn/EN/10.3969/j.issn.1674-8115.2013.05.020
86. Lu YZ, Wu XX, Chen S, Yuan J, Lai CH, Bao LL, Sun LH, Lu W. Effectiveness of Ganoderma lucidum preparation in treating simian acquired immune deficiency syndrome. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2011 Jun;33(3):318-24. doi: 10.3881/j.issn.1000-503X.2011.03.021. PMID: 21718617.
https://pubmed.ncbi.nlm.nih.gov/21718617/
87. Wei B, Zhang R, Zhai J, Zhu J, Yang F, Yue D, Liu X, Lu C, Sun X. Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides. J Immunol Res. 2018 May 20;2018:2906494. doi: 10.1155/2018/2906494. PMID: 29888292; PMCID: PMC5985119.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5985119/
88. Hsu HY, Kuan YC, Lin TY, Tsao SM, Hsu J, Ma LJ, Sheu F. Reishi Protein LZ-8 Induces FOXP3(+) Treg Expansion via a CD45-Dependent Signaling Pathway and Alleviates Acute Intestinal Inflammation in Mice. Evid Based Complement Alternat Med. 2013;2013:513542. doi: 10.1155/2013/513542. Epub 2013 Jun 24. PMID: 23864893; PMCID: PMC3707273.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3707273/
89. Dandapat, Sukumar & Srivastava, Rohit & Sinha, Manoranjan. (2021). Study on impact of silver nanoparticles synthesized using aqueous extract of Ganoderma applanatum on thyroid and lipid parameters of albino rat. Anales de Biología. 43. 123-137. 10.6018/analesbio.43.14.
https://www.um.es/analesdebiologia/numeros/43/PDF/43_2021_14.pdf
90. Qiu, Y., Mao, ZJ., Ruan, YP. et al. Exploration of the anti-insomnia mechanism of Ganoderma by central-peripheral multi-level interaction network analysis. BMC Microbiol 21, 296 (2021). https://doi.org/10.1186/s12866-021-02361-5
https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-021-02361-5
91. Pazzi, F.; Adsuar, J.C.; Domínguez-Muñoz, F.J.; García-Gordillo, M.A.; Gusi, N.; Collado-Mateo, D. Ganoderma lucidum Effects on Mood and Health-Related Quality of Life in Women with Fibromyalgia. Healthcare 2020, 8, 520. https://doi.org/10.3390/healthcare8040520
https://www.mdpi.com/2227-9032/8/4/520
92. Plosca, M.-P.; Chiș, M.S.; Fărcaș, A.C.; Păucean, A. Ganoderma lucidum—From Ancient Remedies to Modern Applications: Chemistry, Benefits, and Safety. Antioxidants 2025, 14, 513. https://doi.org/10.3390/antiox14050513
https://www.mdpi.com/2076-3921/14/5/513
93. Zheng DS, Chen LS. Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors. Exp Ther Med. 2017 Oct;14(4):3273-3278. doi: 10.3892/etm.2017.4883. Epub 2017 Aug 3. PMID: 28912878; PMCID: PMC5585879.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5585879/
94. Cör Andrejč D, Knez Ž, Knez Marevci M. Antioxidant, antibacterial, antitumor, antifungal, antiviral, anti-inflammatory, and nevro-protective activity of Ganoderma lucidum: An overview. Front Pharmacol. 2022 Jul 22;13:934982. doi: 10.3389/fphar.2022.934982. PMID: 35935849; PMCID: PMC9353308.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9353308/
95. Sijia Wu, Siyuan Zhang, Bo Peng, Dechao Tan, Mingyue Wu, Jinchao Wei, Yitao Wang, Hua Luo, Ganoderma lucidum: a comprehensive review of phytochemistry, efficacy, safety and clinical study, Food Science and Human Wellness, Volume 13, Issue 2, 2024, Pages 568-596, ISSN 2213-4530, https://doi.org/10.26599/FSHW.2022.9250051.
https://www.sciencedirect.com/science/article/pii/S2213453023001854
96. Iwatsuki K, Akihisa T, Tokuda H, Ukiya M, Oshikubo M, Kimura Y, Asano T, Nomura A, Nishino H. Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation. J Nat Prod. 2003 Dec;66(12):1582-5. doi: 10.1021/np0302293. PMID: 14695801.
https://pubmed.ncbi.nlm.nih.gov/14695801/
97. Natural Endocrine Solutions, September 15, 2022, The Role of Medicinal Mushrooms in Graves’ Disease and Hashimoto’s,
https://www.naturalendocrinesolutions.com/2022/09/15/the-role-of-medicinal-mushrooms-in-graves-disease-and-hashimotos/
98. Herbs for Hypothyroid, Dr. Tara Burke,
https://drtaraburke.com/herbs-for-hypothyroid/
99. How Medicinal Mushrooms Can Improve Your Thyroid Health, Aggie McCabe, July 13, 2024
https://aggiemccabe.com/2024/07/medicinal-mushrooms-for-thyroid-health
100. Treating Thyroid Disease: A Natural Approach to Healing Hashimoto’s, Melissa Lea-Foster Rietz, FNP-BC, BC-ADM, RYT-200 Presbyterian Medical Services Farmington, NM
https://cdn.ymaws.com/www.nmnpc.org/resource/resmgr/2016_conference/presentations/rietz_thyroid_final.pdf
101. Adaptogenic Herbs and Hashimoto’s Disease, 7.5.2022, Written by: Julia Walker, RN, BSN Medically Reviewed by: Ellen Landes, Paloma Health
https://www.palomahealth.com/learn/adaptogenic-herbs-hashimotos?srsltid=AfmBOooC8nKemf2SecCRJ2iOW3ZkOma3M0ysT9ZfcHZLhFSYHO_mB7sd
102. Controversy: Is Coffee Bad For Your Thyroid? Medically reviewed and written by Izabella Wentz, PharmD, FASCP Dr. Izabella Wentz / February 2, 2024
https://thyroidpharmacist.com/articles/controversy-coffee-bad-thyroid-myths-truths/
103. We Analyzed Mushrooms For Thyroid Health: Our Expert Take by Sony Sherpa Updated On: June 15, 2023
https://www.naturesrise.com/blogs/brainfood/mushrooms-for-thyroid?srsltid=AfmBOopcbHE4S3T8GPVBcR_efFCF7GZZg3S1GI_GUaIoB1OZOErzpXm_
104. Herbal Medicines for Thyroid Disorders Dr. Nikolas Hedberg In Hashimoto’s Disease, Thyroid
https://drhedberg.com/herbal-medicines-for-thyroid-disorders/
105. Environmental Origins of Thyroid Disease – Part 1 Origins of Thyroid Disease – Yarrow – achillea_millefolium By Dr. Ryan Drum
https://naturespiritherbs.com/environmental-origins-of-thyroid-disease-part-1/
106. TIROIDE sotto controllo: il POTERE dei FUNGHI MEDICINALI ! Dr. Ivo Bianchi
https://www.youtube.com/watch?v=Ylhh988ybxY
107. Soffri di TIROIDITE di HASHIMOTO? Ecco come i FUNGHI MEDICINALI possono aiutarti! Dr. Ivo Bianchi
https://www.youtube.com/watch?v=MtTFFWndsWo
108. Reishi – The vital mushroom of millennial life December 13, 2021 Dr. Dorothee Bös et al
https://www.mykotroph.de/en/reishi/
109. American Botanical Council, Specific Indications: Herbs for Endocrine Conditions
http://abc.herbalgram.org/site/DocServer/HerbalFormulariesV3_excerpt_54-59.pdf;jsessionid=00000000.app20116a?docID=9683&NONCE_TOKEN=6A48839F46C17061616D174E05E609CE
110. He T, Zhao R, Lu Y, Li W, Hou X, Sun Y, Dong M, Chen L. Dual-Directional Immunomodulatory Effects of Corbrin Capsule on Autoimmune Thyroid Diseases. Evid Based Complement Alternat Med. 2016;2016:1360386. doi: 10.1155/2016/1360386. Epub 2016 Sep 18. PMID: 27721890; PMCID: PMC5045992.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045992/
111. Exploring the Uses of the Top Medicinal Mushrooms, 04/04/2023, SCHOOL OF GRADUATE STUDIES Universiti Putra Malaysia, 43400 UPM Serdang ,Selangor
https://sgs.upm.edu.my/article/exploring_the_uses_of_the_top_medicinal_mushrooms-71534
Χοληστερόλη
16. What are the risks from taking statins? Ask the doctor February 1, 2025 By Christopher P. Cannon, MD, Editor in Chief, Harvard Heart Letter; Editorial Advisory Board Member, Harvard Health Publishing
https://www.health.harvard.edu/heart-health/what-are-the-risks-from-taking-statins
17. Statin side effects: Weigh the benefits and risks, By Mayo Clinic Staff
https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statin-side-effects/art-20046013
18. June 16, 2021 CARDIOVASCULAR Some Statins Appear to Increase Dementia in Patients With Mild Cognitive Issues, US Pharmacist
https://www.uspharmacist.com/article/some-statins-appear-to-increase-dementia-in-patients-with-mild-cognitive-issues
19. Do Statins Increase or Decrease Alzheimer’s Risk? James M. Ellison, MD, MPH, Geriatric Psychiatrist, Swank Center for Memory Care and Geriatric Consultation, ChristianaCare, Feb 9, 2024, BrightFocus Foundation
https://www.brightfocus.org/resource/do-statins-increase-or-decrease-alzheimers-risk/
20. Which statin is associated with the lowest risk of myalgia? September 29, 2015, new york state department of health
https://nypep.nysdoh.suny.edu/wp-content/uploads/2021/09/DIRC_SUNY_statins-and-myalgia_v2_9.29.15-fin.pdf
21. Stroes ES, Thompson PD, Corsini A, Vladutiu GD, Raal FJ, Ray KK, Roden M, Stein E, Tokgözoğlu L, Nordestgaard BG, Bruckert E, De Backer G, Krauss RM, Laufs U, Santos RD, Hegele RA, Hovingh GK, Leiter LA, Mach F, März W, Newman CB, Wiklund O, Jacobson TA, Catapano AL, Chapman MJ, Ginsberg HN; European Atherosclerosis Society Consensus Panel. Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management. Eur Heart J. 2015 May 1;36(17):1012-22. doi: 10.1093/eurheartj/ehv043. Epub 2015 Feb 18. PMID: 25694464; PMCID: PMC4416140.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4416140/
22. Leaf A. Dietary prevention of coronary heart disease: the Lyon Diet Heart Study. Circulation. 1999 Feb 16;99(6):733-5. doi: 10.1161/01.cir.99.6.733. PMID: 9989956.
https://www.ahajournals.org/doi/10.1161/01.cir.99.6.733
23. About Cholesterol, May 15, 2024, CDC of USA
https://www.cdc.gov/cholesterol/about/index.html
24. What Your Cholesterol Levels Mean, American Heart Association, Feb 16, 2024
https://www.heart.org/en/health-topics/cholesterol/about-cholesterol/what-your-cholesterol-levels-mean
Αιματοκρίτης
454. hematocrit, National Cancer Institute at the National Institutes of Health
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/hematocrit
455. Mondal H, Zubair M. Hematocrit. [Updated 2024 Oct 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK542276/
456. Billett HH. Hemoglobin and Hematocrit. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Boston: Butterworths; 1990. Chapter 151.
https://www.ncbi.nlm.nih.gov/books/NBK259/
457. Turner J, Parsi M, Badireddy M. Anemia. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK499994/
458. F.G. Huffman, S. Nath, Z.C. Shah, ANEMIA (ANAEMIA) | Other Nutritional Causes, Editor(s): Benjamin Caballero, Encyclopedia of Food Sciences and Nutrition (Second Edition), Academic Press, 2003, Pages 226-232, ISBN 9780122270550, https://doi.org/10.1016/B0-12-227055-X/00043-2.
https://www.sciencedirect.com/topics/veterinary-science-and-veterinary-medicine/nutritional-anemia
459. Killeen RB, Kaur A, Afzal M. Acute Anemia. [Updated 2025 Feb 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537232/
460. Stevens GA, Paciorek CJ, Flores-Urrutia MC, Borghi E, Namaste S, Wirth JP, Suchdev PS, Ezzati M, Rohner F, Flaxman SR, Rogers LM. National, regional, and global estimates of anaemia by severity in women and children for 2000-19: a pooled analysis of population-representative data. Lancet Glob Health. 2022 May;10(5):e627-e639. doi: 10.1016/S2214-109X(22)00084-5. PMID: 35427520; PMCID: PMC9023869.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9023869/
461. Malenica M, Prnjavorac B, Bego T, Dujic T, Semiz S, Skrbo S, Gusic A, Hadzic A, Causevic A. Effect of Cigarette Smoking on Haematological Parameters in Healthy Population. Med Arch. 2017 Apr;71(2):132-136. doi: 10.5455/medarh.2017.71.132-136. PMID: 28790546; PMCID: PMC5511531.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5511531/
462. Vitak T, Yurkiv B, Wasser S, Nevo E, Sybirna N. Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus. World J Diabetes. 2017 May 15;8(5):187-201. doi: 10.4239/wjd.v8.i5.187. PMID: 28572880; PMCID: PMC5437617.
https://pubmed.ncbi.nlm.nih.gov/28572880/
463. Teja KS, Suruchi, Rai U, Kumar M, Mohanty O, Roy J, Meshram S. Mushrooms: A Potential Option in the Management of Deficiency and Diseases in Humans. J Pure Appl Microbiol. 2023;17(2):749-760. doi: 10.22207/JPAM.17.2.55
https://microbiologyjournal.org/mushrooms-a-potential-option-in-the-management-of-deficiency-and-diseases-in-humans/
Ακμή
406. Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton SB, Brand-Miller J. Acne vulgaris: a disease of Western civilization. Arch Dermatol. 2002 Dec;138(12):1584-90. doi: 10.1001/archderm.138.12.1584. PMID: 12472346.
https://pubmed.ncbi.nlm.nih.gov/12472346/
407. Matsui MS. Update on diet and acne. Cutis. 2019 Jul;104(1):11-13. PMID: 31487341.
https://cdn.mdedge.com/files/s3fs-public/CT104001011.PDF
408. J Am Acad Dermatol. 2016 May;74(5):945-73.e33. doi: 10.1016/j.jaad.2015.12.037. Epub 2016 Feb 17. Guidelines of Care for the Management of Acne Vulgaris Andrea L Zaenglein, Arun L Pathy, Bethanee J Schlosser, Ali Alikhan, Hilary E Baldwin, Diane S Berson, Whitney P Bowe, Emmy M Graber, Julie C Harper, Sewon Kang, Jonette E Keri, James J Leyden, Rachel V Reynolds, Nanette B Silverberg, Linda F Stein Gold, Megha M Tollefson, Jonathan S Weiss, Nancy C Dolan, Andrew A Sagan, Mackenzie Stern, Kevin M Boyer, Reva Bhushan
https://pubmed.ncbi.nlm.nih.gov/26897386
409. Am Fam Physician. 2019 Oct 15;100(8):475-484. Acne Vulgaris: Diagnosis and Treatment Linda K Oge', Alan Broussard, Marilyn D Marshall
https://pubmed.ncbi.nlm.nih.gov/31613567
410. Br J Dermatol. 2015 Jul;172 Suppl 1:3-12. doi: 10.1111/bjd.13462. A Global Perspective on the Epidemiology of Acne J K L Tan, K Bhate
https://pubmed.ncbi.nlm.nih.gov/25597339
411. Eur J Dermatol . 2017 Aug 1;27(4):393-398. doi: 10.1684/ejd.2017.3062. Adult Female Acne Treated With Spironolactone: A Retrospective Data Review of 70 Cases Anne Isvy-Joubert, Jean-Michel Nguyen, Aurélie Gaultier, Mélanie Saint-Jean, Marie Le Moigne, Elodie Boisrobert, Amir Khammari, Brigitte Dreno
https://pubmed.ncbi.nlm.nih.gov/28862134
412. Acta Derm Venereol . 2013 Nov;93(6):644-9. doi: 10.2340/00015555-1677. Acne: Risk Indicator for Increased Body Mass Index and Insulin Resistance Bodo C Melnik 1 , Swen Malte John, Gerd Plewig
https://pubmed.ncbi.nlm.nih.gov/23975508/
https://www.researchgate.net/publication/256102062_Acne_Risk_Indicator_for_Increased_Body_Mass_Index_and_Insulin_Resistance
413.Cochrane Database Syst Rev. 2018 Nov 24;11(11):CD009435. doi: 10.1002/14651858.CD009435.pub2. Oral Isotretinoin for Acne Caroline S Costa , Ediléia Bagatin, Ana Luiza C Martimbianco, Edina Mk da Silva, Marília M Lúcio, Parker Magin, Rachel Riera
https://pubmed.ncbi.nlm.nih.gov/30484286
414. Am J Clin Dermatol. 2017 Jun;18(3):311-321. doi: 10.1007/s40257-017-0255-3. The Role of Photodynamic Therapy in Acne: An Evidence-Based Review Monica Boen, Joshua Brownell, Priyanka Patel, Maria M Tsoukas
https://pubmed.ncbi.nlm.nih.gov/28276005
415. Wiad Lek. 2018;71(1 pt 2):144-147. Indicators of Phagocytosis in Women With Acne During Comprehensive Treatment That Included Immunotherapy and Probiotics Orysya О Syzon, Marianna О Dashko
https://pubmed.ncbi.nlm.nih.gov/29602922
416. Cochrane Database Syst Rev. 2016 Apr 3;4(4):CD011946. doi: 10.1002/14651858.CD011946.pub2. Interventions for Acne Scars Rania Abdel Hay, Khalid Shalaby, Hesham Zaher, Vanessa Hafez, Ching-Chi Chi, Sandra Dimitri, Ashraf F Nabhan, Alison M Layton
https://pubmed.ncbi.nlm.nih.gov/27038134
417. Wu, Y.; Choi, M.-H.; Li, J.; Yang, H.; Shin, H.-J. Mushroom Cosmetics: The Present and Future. Cosmetics 2016, 3, 22. https://doi.org/10.3390/cosmetics3030022
https://www.mdpi.com/2079-9284/3/3/22
Αθλητισμός
375. Purcell LK; Canadian Paediatric Society, Paediatric Sports and Exercise Medicine Section. Sport nutrition for young athletes. Paediatr Child Health. 2013 Apr;18(4):200-5. doi: 10.1093/pch/18.4.200. PMID: 24421690; PMCID: PMC3805623.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3805623/
376. Maughan RJ, Depiesse F, Geyer H; International Association of Athletics Federations. The use of dietary supplements by athletes. J Sports Sci. 2007;25 Suppl 1:S103-13. doi: 10.1080/02640410701607395. Erratum in: J Sports Sci. 2009 Apr;27(6):667. PMID: 18049988.
https://pubmed.ncbi.nlm.nih.gov/18049988/
377. Yuping Zhu, Gang Song, Molecular origin and biological effects of exercise mimetics, Journal of Exercise Science & Fitness, Volume 22, Issue 1, 2024, Pages 73-85, ISSN 1728-869X, https://doi.org/10.1016/j.jesf.2023.12.002.
https://www.sciencedirect.com/science/article/pii/S1728869X23000643
378. Giacomello, E.; Nicoletti, C.; Canato, M.; Toniolo, L. Exercise Mimetics in Aging: Suggestions from a Systematic Review. Nutrients 2025, 17, 969. https://doi.org/10.3390/nu17060969
https://www.mdpi.com/2072-6643/17/6/969
379. Gubert C, Hannan AJ. Exercise mimetics: harnessing the therapeutic effects of physical activity. Nat Rev Drug Discov. 2021 Nov;20(11):862-879. doi: 10.1038/s41573-021-00217-1. Epub 2021 Jun 8. PMID: 34103713.
https://pubmed.ncbi.nlm.nih.gov/34103713/
380. Vedant Samant, Arati Prabhu, Exercise, exerkines and exercise mimetic drugs: Molecular mechanisms and therapeutics, Life Sciences, Volume 359, 2024, 123225, ISSN 0024-3205, https://doi.org/10.1016/j.lfs.2024.123225.
https://www.sciencedirect.com/science/article/abs/pii/S0024320524008154
381. Li, S. and Laher, I. (2017), Exercise Mimetics: Running Without a Road Map. Clin. Pharmacol. Ther., 101: 188-190. https://doi.org/10.1002/cpt.533
https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.533
382. Cento, A.S., Leigheb, M., Caretti, G. et al. Exercise and Exercise Mimetics for the Treatment of Musculoskeletal Disorders. Curr Osteoporos Rep 20, 249–259 (2022). https://doi.org/10.1007/s11914-022-00739-6
https://link.springer.com/article/10.1007/s11914-022-00739-6
383. Fan W, Evans RM. Exercise Mimetics: Impact on Health and Performance. Cell Metab. 2017 Feb 7;25(2):242-247. doi: 10.1016/j.cmet.2016.10.022. Epub 2016 Nov 23. PMID: 27889389; PMCID: PMC5555683.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5555683/
384. Zhao, R. Exercise mimetics: a novel strategy to combat neuroinflammation and Alzheimer’s disease. J Neuroinflammation 21, 40 (2024). https://doi.org/10.1186/s12974-024-03031-9
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-024-03031-9
385. Silver MD. Use of ergogenic aids by athletes. J Am Acad Orthop Surg. 2001 Jan-Feb;9(1):61-70. doi: 10.5435/00124635-200101000-00007. PMID: 11174164.
https://pubmed.ncbi.nlm.nih.gov/11174164/
386. Varillas-Delgado, D. Nutritional Status and Ergogenic Aids in Performance During Exercise and Sports. Nutrients 2025, 17, 1224. https://doi.org/10.3390/nu17071224
https://www.mdpi.com/2072-6643/17/7/1224
387. Thein LA, Thein JM, Landry GL. Ergogenic aids. Phys Ther. 1995 May;75(5):426-39. doi: 10.1093/ptj/75.5.426. PMID: 7732086.
https://pubmed.ncbi.nlm.nih.gov/7732086/
388. Institute of Medicine (US) Committee on Military Nutrition Research; Marriott BM, editor. Food Components to Enhance Performance: An Evaluation of Potential Performance-Enhancing Food Components for Operational Rations. Washington (DC): National Academies Press (US); 1994. 12, Food Components That May Optimize Physical Performance: An Overview.
https://www.ncbi.nlm.nih.gov/books/NBK209034/
389. Ketterly J. Sports Medicine: Ergogenic Aids. FP Essent. 2022 Jul;518:23-28. PMID: 35830325.
https://pubmed.ncbi.nlm.nih.gov/35830325/
390. Maughan RJ. Nutritional ergogenic aids and exercise performance. Nutr Res Rev. 1999 Dec;12(2):255-80. doi: 10.1079/095442299108728956. PMID: 19087454.
https://pubmed.ncbi.nlm.nih.gov/19087454/
391. Wickham KA, Spriet LL. Food for thought: Physiological considerations for nutritional ergogenic efficacy. Scand J Med Sci Sports. 2024; 34:e14307. doi:10.1111/sms.14307
https://onlinelibrary.wiley.com/doi/10.1111/sms.14307
392. Ahrendt DM. Ergogenic aids: counseling the athlete. Am Fam Physician. 2001 Mar 1;63(5):913-22. PMID: 11261867.
https://www.aafp.org/pubs/afp/issues/2001/0301/p913.html
393. Chelladurai, Packianathan. (2008). Athletics IS Education: A Response to Kane, Leo, and Holleran’s (2008) Case Study of University of Minnesota Student-Athletes. Journal of Intercollegiate Sport. 1. 130-138. 10.1123/jis.1.1.130.
https://www.researchgate.net/publication/306054098_Athletics_IS_Education_A_Response_to_Kane_Leo_and_Holleran's_2008_Case_Study_of_University_of_Minnesota_Student-Athletes
394. Forbes SC, Best R and Dominguez R (2024) Editorial: Dietary supplements and ergogenic aids in relation to health and performance. Front. Sports Act. Living 6:1450604. doi: 10.3389/fspor.2024.1450604
https://www.frontiersin.org/journals/sports-and-active-living/articles/10.3389/fspor.2024.1450604/full
395. Dunn J, Grider MH. Physiology, Adenosine Triphosphate. [Updated 2023 Feb 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK553175/
https://www.ncbi.nlm.nih.gov/books/NBK553175/
396. Ralf Jäger, Martin Purpura, John A. Rathmacher, John C. Fuller, Lisa M. Pitchford, Fabricio E. Rossi, Chad M. Kerksick, Health and ergogenic potential of oral adenosine-5′-triphosphate (ATP) supplementation, Journal of Functional Foods, Volume 78, 2021, 104357, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2021.104357.
https://www.sciencedirect.com/science/article/pii/S1756464621000062
397. Morgan A. O'Brien, Derek G. Power, A. James P. Clover, Brian Bird, Declan M. Soden, Patrick F. Forde, Local tumour ablative therapies: Opportunities for maximising immune engagement and activation, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1846, Issue 2, 2014, Pages 510-523, ISSN 0304-419X, https://doi.org/10.1016/j.bbcan.2014.09.005.
https://www.sciencedirect.com/science/article/pii/S0304419X14000870
398. Greiner, J.V.; Glonek, T. Adenosine Triphosphate (ATP) and Protein Aggregation in Age-Related Vision-Threatening Ocular Diseases. Metabolites 2023, 13, 1100. https://doi.org/10.3390/metabo13101100
https://www.mdpi.com/2218-1989/13/10/1100
399. Jensen J, Rustad PI, Kolnes AJ, Lai YC. The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise. Front Physiol. 2011 Dec 30;2:112. doi: 10.3389/fphys.2011.00112. PMID: 22232606; PMCID: PMC3248697.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3248697/
400. Knuiman, P., Hopman, M.T.E. & Mensink, M. Glycogen availability and skeletal muscle adaptations with endurance and resistance exercise. Nutr Metab (Lond) 12, 59 (2015). https://doi.org/10.1186/s12986-015-0055-9
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-015-0055-9
401. Iliana López-Soldado, Joan J. Guinovart, Jordi Duran, Increased liver glycogen levels enhance exercise capacity in mice, Journal of Biological Chemistry, Volume 297, Issue 2, 2021, 100976, ISSN 0021-9258, https://doi.org/10.1016/j.jbc.2021.100976.
https://www.sciencedirect.com/science/article/pii/S002192582100778X
402. Ørtenblad N, Westerblad H, Nielsen J. Muscle glycogen stores and fatigue. J Physiol. 2013 Sep 15;591(18):4405-13. doi: 10.1113/jphysiol.2013.251629. Epub 2013 May 7. PMID: 23652590; PMCID: PMC3784189.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3784189/
403. Yun-tao Ma, CHAPTER 5 - Overtraining Syndrome and the Use of Muscle in Exercise, Editor(s): Yun-tao Ma, Acupuncture for Sports and Trauma Rehabilitation, Churchill Livingstone, 2011, Pages 36-48, ISBN 9781437709278, https://doi.org/10.1016/B978-1-4377-0927-8.00005-1.
https://www.sciencedirect.com/topics/immunology-and-microbiology/muscle-fatigue
404. W.W. Hay, GROWTH AND DEVELOPMENT, PHYSIOLOGICAL ASPECTS, Editor(s): Benjamin Caballero, Encyclopedia of Human Nutrition (Second Edition), Elsevier, 2005, Pages 423-433, ISBN 9780122266942, https://doi.org/10.1016/B0-12-226694-3/00156-3.
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/glycogen-liver-level
405. Glycogen, Last reviewed on 07/13/2022. Cleveland Clinic
https://my.clevelandclinic.org/health/articles/23509-glycogen
494. Thiebaud, Robert. (2012). Exercise-Induced Muscle Damage: Is it detrimental or beneficial?. Journal of Trainology. 1. 36-44. 10.17338/trainology.1.2_36.
https://www.jstage.jst.go.jp/article/trainology/1/2/1_36/_article
495. Owens DJ, Twist C, Cobley JN, Howatson G, Close GL. Exercise-induced muscle damage: What is it, what causes it and what are the nutritional solutions? Eur J Sport Sci. 2019 Feb;19(1):71-85. doi: 10.1080/17461391.2018.1505957. Epub 2018 Aug 15. PMID: 30110239.
https://pubmed.ncbi.nlm.nih.gov/30110239/
496. Howatson G, van Someren KA. The prevention and treatment of exercise-induced muscle damage. Sports Med. 2008;38(6):483-503. doi: 10.2165/00007256-200838060-00004. PMID: 18489195.
https://pubmed.ncbi.nlm.nih.gov/18489195/
497. Harty, P.S., Cottet, M.L., Malloy, J.K. et al. Nutritional and Supplementation Strategies to Prevent and Attenuate Exercise-Induced Muscle Damage: a Brief Review. Sports Med - Open 5, 1 (2019). https://doi.org/10.1186/s40798-018-0176-6
https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-018-0176-6.
498. Leite, C.D.F.C.; Zovico, P.V.C.; Rica, R.L.; Barros, B.M.; Machado, A.F.; Evangelista, A.L.; Leite, R.D.; Barauna, V.G.; Maia, A.F.; Bocalini, D.S. Exercise-Induced Muscle Damage after a High-Intensity Interval Exercise Session: Systematic Review. Int. J. Environ. Res. Public Health 2023, 20, 7082. https://doi.org/10.3390/ijerph20227082
https://www.mdpi.com/1660-4601/20/22/7082
499. Sunbol, Khalid & Althiyabi, Fahad & Alshuria, Abdulaziz & Alajwad, Mahdi & Mahlawi, Amoudi & Alsayed, Budur & Alsarhan, Mustafa & Alshehri, Rahaf & Alsahli, Abdulaziz & Alhazmi, Khalid & Esmae, Emtenan. (2022). Etiology, risk factors and complications of exercise induced muscle injury. International Journal Of Community Medicine And Public Health. 10. 10.18203/2394-6040.ijcmph20223319.
https://www.researchgate.net/publication/366387424_Etiology_risk_factors_and_complications_of_exercise_induced_muscle_injury
500. Price TB, Krishnan-Sarin S, Rothman DL. Smoking impairs muscle recovery from exercise. Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E116-22. doi: 10.1152/ajpendo.00543.2002. Epub 2003 Mar 11. PMID: 12637259.
https://pubmed.ncbi.nlm.nih.gov/12637259/
501. İpekoğlu, Gökhan & Taskin, Halil & Şenel, Ömer. (2019). Examination of Exercise-Induced Skeletal and Cardiac Muscle Damage in Terms of Smoking. Montenegrin Journal of Sports Science & Medicine. 8. 10.26773/mjssm.190901.
https://www.researchgate.net/publication/332111862_Examination_of_Exercise-Induced_Skeletal_and_Cardiac_Muscle_Damage_in_Terms_of_Smoking
502. Xu, F.; Zeng, J.; Liu, X.; Lai, J.; Xu, J. Exercise-Induced Muscle Damage and Protein Intake: A Bibliometric and Visual Analysis. Nutrients 2022, 14, 4288. https://doi.org/10.3390/nu14204288
https://www.mdpi.com/2072-6643/14/20/4288
593. Cabaniss CD. Creatine Kinase. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Boston: Butterworths; 1990. Chapter 32.
https://www.ncbi.nlm.nih.gov/books/NBK352/https://www.ncbi.nlm.nih.gov/books/NBK352/
594. Brian R. Berridge, John F. Van Vleet, Eugene Herman, Chapter 46 - Cardiac, Vascular, and Skeletal Muscle Systems, Editor(s): Wanda M. Haschek, Colin G. Rousseaux, Matthew A. Wallig, Haschek and Rousseaux's Handbook of Toxicologic Pathology (Third Edition), Academic Press, 2013, Pages 1567-1665, ISBN 9780124157590, https://doi.org/10.1016/B978-0-12-415759-0.00046-7.
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/creatine-kinase
595. Moghadam-Kia S, Oddis CV, Aggarwal R. Approach to asymptomatic creatine kinase elevation. Cleve Clin J Med. 2016 Jan;83(1):37-42. doi: 10.3949/ccjm.83a.14120. PMID: 26760521; PMCID: PMC4871266.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4871266/
596. David S. Younger, Chapter 19 - Childhood muscular dystrophies, Editor(s): David S. Younger, Handbook of Clinical Neurology, Elsevier, Volume 195, 2023, Pages 461-496, ISSN 0072-9752, ISBN 9780323988186, https://doi.org/10.1016/B978-0-323-98818-6.00024-8.
https://www.sciencedirect.com/topics/nursing-and-health-professions/creatine-kinase-blood-level
597. Laurence A. Bindoff, CHAPTER 33 - Muscle disease, Editor(s): William J. Marshall, Marta Lapsley, Andrew P. Day, Ruth M. Ayling, Clinical Biochemistry: Metabolic and Clinical Aspects (Third Edition), Churchill Livingstone, 2014, Pages 646-659, ISBN 9780702051401, https://doi.org/10.1016/B978-0-7020-5140-1.00033-X.
https://www.sciencedirect.com/topics/nursing-and-health-professions/creatine-kinase-mm
598. Al-Naseem A, Sallam A, Choudhury S, Thachil J. Iron deficiency without anaemia: a diagnosis that matters. Clin Med (Lond). 2021 Mar;21(2):107-113. doi: 10.7861/clinmed.2020-0582. PMID: 33762368; PMCID: PMC8002799.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8002799/
599. Dufaux B, Hoederath A, Streitberger I, Hollmann W, Assmann G. Serum ferritin, transferrin, haptoglobin, and iron in middle- and long-distance runners, elite rowers, and professional racing cyclists. Int J Sports Med. 1981 Feb;2(1):43-6. doi: 10.1055/s-2008-1034583. PMID: 7333734.
https://pubmed.ncbi.nlm.nih.gov/7333734/
600. Nachtigall D, Nielsen P, Fischer R, Engelhardt R, Gabbe EE. Iron deficiency in distance runners. A reinvestigation using Fe-labelling and non-invasive liver iron quantification. Int J Sports Med. 1996 Oct;17(7):473-9. doi: 10.1055/s-2007-972881. PMID: 8912060.
https://pubmed.ncbi.nlm.nih.gov/8912060/
601. Dickson DN, Wilkinson RL, Noakes TD. Effects of ultra-marathon training and racing on hematologic parameters and serum ferritin levels in well-trained athletes. Int J Sports Med. 1982 May;3(2):111-7. doi: 10.1055/s-2008-1026073. PMID: 7107103.
https://pubmed.ncbi.nlm.nih.gov/7107103/
602. Stanzione JR, Bell G, Greenwood DA. A systematic nutrition intervention for low iron status in collegiate distance runners. Nutr Health. 2022 May 9:2601060221100337. doi: 10.1177/02601060221100337. Epub ahead of print. PMID: 35532088.
https://pubmed.ncbi.nlm.nih.gov/35532088/
603. Lai T-F, Liao Y, Hsueh M-C, Yen H-Y, Park J-H and Chang JH (2022) Substituting sedentary time with physical activity in youngest-old to oldest-old community-dwelling older adults: Associations with body composition. Front. Public Health 10:837213. doi: 10.3389/fpubh.2022.837213
https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.837213/full
604. Huang Z, Liu Y, Zhou Y. Sedentary Behaviors and Health Outcomes among Young Adults: A Systematic Review of Longitudinal Studies. Healthcare (Basel). 2022 Aug 6;10(8):1480. doi: 10.3390/healthcare10081480. PMID: 36011137; PMCID: PMC9408295.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9408295/
605. Bouamra M, Zouhal H, Ratel S, Makhlouf I, Bezrati I, Chtara M, Behm DG, Granacher U and Chaouachi A (2022) Concurrent Training Promotes Greater Gains on Body Composition and Components of Physical Fitness Than Single-Mode Training (Endurance or Resistance) in Youth With Obesity. Front. Physiol. 13:869063. doi: 10.3389/fphys.2022.869063
https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.869063/full
606. W.Clark Hersey, James E. Graves, Michael L. Pollock, Ronald Gingerich, Rachel B. Shireman, Gregory W. Heath, Francis Spierto, Steve D. McCole, James M. Hagberg, Endurance exercise training improves body composition and plasma insulin responses in 70- to 79-year-old men and women, Metabolism, Volume 43, Issue 7, 1994, Pages 847-854, ISSN 0026-0495, https://doi.org/10.1016/0026-0495(94)90265-8.
https://www.sciencedirect.com/science/article/abs/pii/0026049594902658
607. Júdice PB, Hetherington-Rauth M, Magalhães JP, Correia IR, Sardinha LB. Sedentary behaviours and their relationship with body composition of athletes. Eur J Sport Sci. 2022 Mar;22(3):474-480. doi: 10.1080/17461391.2021.1874060. Epub 2021 Feb 2. PMID: 33416024.
https://pubmed.ncbi.nlm.nih.gov/33416024/
608. SEPTEMBER 28, 2022 High-intensity workouts can help you get fit fast, but preparation is key By Cultivating Health, UC Davis Health
https://health.ucdavis.edu/blog/cultivating-health/high-intensity-workouts-can-help-you-get-fit-fast-but-preparation-is-key/2022/09
609. Verbrugghe J, Agten A, Stevens S, Hansen D, Demoulin C, Eijnde BO, Vandenabeele F, Timmermans A. High Intensity Training to Treat Chronic Nonspecific Low Back Pain: Effectiveness of Various Exercise Modes. J Clin Med. 2020 Jul 27;9(8):2401. doi: 10.3390/jcm9082401. PMID: 32727108; PMCID: PMC7465397.
https://pubmed.ncbi.nlm.nih.gov/32727108/
Ε1. Cordyceps Sinensis, Canadian Academy of Sports Nutrition
https://www.caasn.com/cordyceps-sinensis.html
Ε2. Geng P, Siu KC, Wang Z, Wu JY. Antifatigue Functions and Mechanisms of Edible and Medicinal Mushrooms. Biomed Res Int. 2017;2017:9648496. doi: 10.1155/2017/9648496. Epub 2017 Aug 14. PMID: 28890898; PMCID: PMC5584359.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584359/
Ε3. Nagata, Akira & Tajima, Taeko & Uchida, Masayuki. (2006). Supplemental anti-fatigue effects of Cordyceps sinensis (Tochu-Kaso) extract powder during three stepwise exercise of human. Japanese Journal of Physical Fitness and Sports Medicine. 55. S145-S152. 10.7600/jspfsm.55.S145.
https://www.semanticscholar.org/paper/SUPPLEMENTAL-ANTI-FATIGUE-EFFECTS-OF-CORDYCEPS-OF-Nagata-Tajima/89969d5885d2b9054560ac6edbda023c28844133
https://www.jstage.jst.go.jp/article/jspfsm/55/Supplement/55_S145/_article
Ε4. Yi, Xiao & Xi-zhen, Huang & Zhu, Jia-Shi. (2004). Randomized double-blind placebo-controlled clinical trial and assessment of fermentation product of Cordyceps sinensis (Cs4) in enhancing aerobic capacity and respiratory function of the healthy elderly volunteers. Chinese Journal of Integrative Medicine - CHIN J INTEGR MED. 10. 187-192. 10.1007/BF02836405.
https://link.springer.com/article/10.1007/BF02836405
https://www.researchgate.net/publication/246146225_Randomized_double-blind_placebo-controlled_clinical_trial_and_assessment_of_fermentation_product_of_Cordyceps_sinensis_Cs4_in_enhancing_aerobic_capacity_and_respiratory_function_of_the_healthy_elderly
Ε5. Applegate EA, Grivetti LE. Search for the competitive edge: a history of dietary fads and supplements. J Nutr. 1997 May;127(5 Suppl):869S-873S. doi: 10.1093/jn/127.5.869S. PMID: 9164254.
https://www.sciencedirect.com/science/article/pii/S0022316622074314
Ε6. Gunes-Bayir A, Çemberci M (2023) A review of ergogenic nutritional supplements for athletes. Arch Sports Med Physiother 8(1): 003-010. DOI: 10.17352/asmp.000017
https://www.peertechzpublications.org/articles/ASMP-8-117.php
Ε7. Chen S, Li Z, Krochmal R, Abrazado M, Kim W, Cooper CB. Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trial. J Altern Complement Med. 2010 May;16(5):585-90. doi: 10.1089/acm.2009.0226. PMID: 20804368; PMCID: PMC3110835.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110835/
Ε8. Savioli, Fellipe & Zogaib, Paulo & Franco, Eduardo & Salles, Fernando & Giorelli, Guilherme & Andreoli, Carlos. (2022). Effects of Cordyceps Sinensis Supplementation during 12 weeks in amateur marathoners: a randomized, double-blind placebo-controlled trial. Journal of Herbal Medicine. 34. 100570. 10.1016/j.hermed.2022.100570.
https://www.sciencedirect.com/science/article/abs/pii/S2210803322000392
Ε9. Hirsch KR, Smith-Ryan AE, Roelofs EJ, Trexler ET, Mock MG. Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation. J Diet Suppl. 2017 Jan 2;14(1):42-53. doi: 10.1080/19390211.2016.1203386. Epub 2016 Jul 13. PMID: 27408987; PMCID: PMC5236007.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5236007/
Ε10. Kumar R, Negi PS, Singh B, Ilavazhagan G, Bhargava K, Sethy NK. Cordyceps sinensis promotes exercise endurance capacity of rats by activating skeletal muscle metabolic regulators. J Ethnopharmacol. 2011 Jun 14;136(1):260-6. doi: 10.1016/j.jep.2011.04.040. Epub 2011 Apr 28. PMID: 21549819.
https://pubmed.ncbi.nlm.nih.gov/21549819/
Ε11. Gubert C, Hannan AJ. Exercise mimetics: harnessing the therapeutic effects of physical activity. Nat Rev Drug Discov. 2021 Nov;20(11):862-879. doi: 10.1038/s41573-021-00217-1. Epub 2021 Jun 8. PMID: 34103713.
Ε12. Wenjuan Yan, Taihui Li, Jinghui Lao, Bin Song & Yaheng Shen (2013) Anti-fatigue property of Cordyceps guangdongensis and the underlying mechanisms, Pharmaceutical Biology, 51:5, 614-620, DOI: 10.3109/13880209.2012.760103
https://www.tandfonline.com/doi/full/10.3109/13880209.2012.760103
https://pubmed.ncbi.nlm.nih.gov/34103713/
Ε13. Mycology News, Volume 1, Edition 6, MARCH 2002
https://www.mycologyresearch.com/articles/view/61
Ε14. Ashar, Hardik D. & Panda, Vandana & Semalty, Ajay & Asrani, Kirtika & Semalty, Mona. (2012). Herbal Drugs in Chronic Fatigue Syndrome: An Overview. Swiss Journal of Integrative Medicine. 24. 10.1159/000339011.
https://karger.com/szg/article-pdf/24/3/155/3560240/000339011.pdf
Ε15. Zhang W, Xu L, Yuan M. Clinical studies of several well-known and valuable herbal medicines: a narrative review. Longhua Chin Med 2022;5:5.
https://lcm.amegroups.org/article/view/8106/html
Ε16. Jędrejko, K.J.; Lazur, J.; Muszyńska, B. Cordyceps militaris: An Overview of Its Chemical Constituents in Relation to Biological Activity. Foods 2021, 10, 2634. https://doi.org/10.3390/foods10112634
https://www.mdpi.com/2304-8158/10/11/2634
Ε17. Chinese mushroom remedy found to boost fitness 19 Apr, 2004 06:04 AM,
https://www.nzherald.co.nz/world/chinese-mushroom-remedy-found-to-boost-fitness/CU332AQCL5PVC3G6CUQJSQ42XI/?c_id=2&objectid=3561385
Ε18. H βίβλος της μέγιστης απόδοσης του Δρ. Earl Mindell Ph.D.
https://www.amazon.com/Earl-Mindells-Peak-Performance-Bible-ebook/dp/B000FC0NS2/ref=sr_1_1?ie=UTF8&qid=undefined&sr=8-1&keywords=Dr+Earl+Mindell%27s+peak+performance+bible
Ε19. Στα Ίχνη του Αρχαίου Κόρντισεπς στο σύγχρονο κόσμο, John Holliday, Matt Cleaver
Ε20.Chen CY, Hou CW, Bernard JR, Chen CC, Hung TC, Cheng LL, Liao YH, Kuo CH. Rhodiola crenulata- and Cordyceps sinensis-based supplement boosts aerobic exercise performance after short-term high altitude training. High Alt Med Biol. 2014 Sep;15(3):371-9. doi: 10.1089/ham.2013.1114. PMID: 25251930; PMCID: PMC4174424.
https://pubmed.ncbi.nlm.nih.gov/25251930/
Ε21. Rossi P, Buonocore D, Altobelli E, Brandalise F, Cesaroni V, Iozzi D, Savino E, Marzatico F. Improving Training Condition Assessment in Endurance Cyclists: Effects of Ganoderma lucidum and Ophiocordyceps sinensis Dietary Supplementation. Evid Based Complement Alternat Med. 2014;2014:979613. doi: 10.1155/2014/979613. Epub 2014 Apr 1. PMID: 24799948; PMCID: PMC3995149.
https://pubmed.ncbi.nlm.nih.gov/24799948/
Καρκίνος
1. Ambhore JP, Adhao VS, Rafique SS, Telgote A, Dhoran RS, Shende BA. A concise review: edible mushroom and their medicinal significance. Explor Foods Foodomics. 2024;2:183–94. https://doi.org/10.37349/eff.2024.00033
https://www.explorationpub.com/Journals/eff/Article/101033
2. Anuradha Mishra, S Shankar, Edible mushrooms for improved human health, food security and environmental sustainability: A critical review, Science of The Total Environment, Volume 995, 2025, 180093, ISSN 0048-9697, https://doi.org/10.1016/j.scitotenv.2025.180093.
https://www.sciencedirect.com/science/article/abs/pii/S0048969725017334
3. Łysakowska, P.; Sobota, A.; Wirkijowska, A. Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production—A Review. Molecules 2023, 28, 5393. https://doi.org/10.3390/molecules28145393
https://www.mdpi.com/1420-3049/28/14/5393
4. Feeney, Mary Jo MS, RDN, FADA, FAND; Miller, Amy Myrdal MS, RDN; Roupas, Peter PhD. Mushrooms—Biologically Distinct and Nutritionally Unique: Exploring a “Third Food Kingdom”. Nutrition Today 49(6):p 301-307, November/December 2014. | DOI: 10.1097/NT.0000000000000063
https://journals.lww.com/nutritiontodayonline/fulltext/2014/11000/mushrooms_biologically_distinct_and_nutritionally.10.aspx
5. Bell, Victoria & Silva, C. & Guina, José Augusto & Th, Fernandes. (2022). Mushrooms as future generation healthy foods. Frontiers in Nutrition. 9. 1050099. 10.3389/fnut.2022.1050099.
https://www.researchgate.net/publication/366031437_Mushrooms_as_future_generation_healthy_foods
6. A Review: Health Benefits and Quality Value of Mushroom Anshu Mala, Shwet Kamal, BL Attri, International Journal for Multidisciplinary Research (IJFMR) E-ISSN: 2582-2160
https://www.ijfmr.com/papers/2023/4/4841.pdf
7. Khan,Najmu Saqib and Kumar,Pranav and Taki,Rachel and Giri,Ramesh and Geetika, 20220422079, English, Journal article, India, 0970-0420, 40, (2A), Kolkata, Environment and Ecology, (540–553), MKK Publication, An overview and study on edible mushrooms: human health benefits and promoting quality of life., (2022)
https://www.cabidigitallibrary.org/doi/full/10.5555/20220422079
8. Valverde ME, Hernández-Pérez T, Paredes-López O. Edible mushrooms: improving human health and promoting quality life. Int J Microbiol. 2015;2015:376387. doi: 10.1155/2015/376387. Epub 2015 Jan 20. PMID: 25685150; PMCID: PMC4320875.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4320875/
9. PDQ® Integrative, Alternative, and Complementary Therapies Editorial Board. PDQ Medicinal Mushrooms. Bethesda, MD: National Cancer Institute. Updated July 11, 2024. Available at: https://www.cancer.gov/about-cancer/treatment/cam/patient/mushrooms-pdq. Accessed <8/1/2025>. [PMID: 28267306]
10. Zmitrovich IV, Bondartseva MA, Arefyev SP, Perelygin VV. Professor Solomon P. Wasser and Medicinal Mushroom Science, with Special Attention to the Problems of Mycotherapy in Oncology. Int J Med Mushrooms. 2022;24(1):13-26. doi: 10.1615/IntJMedMushrooms.2021041831. PMID: 35442592.
https://pubmed.ncbi.nlm.nih.gov/35442592/
11. International Journal of Medicinal Mushrooms Editor-in-Chief: Solomon P. Wasser (open in a new tab) Published 12 issues per year ISSN Print: 1521-9437 ISSN Online: 1940-4344
https://www.dl.begellhouse.com/journals/708ae68d64b17c52,35ee20ab487c6e00,26e32c6444922c12.html
12. Int J Med Mushrooms, 19 (4), 279-317 2017 Medicinal Mushrooms in Human Clinical Studies. Part I. Anticancer, Oncoimmunological, and Immunomodulatory Activities: A Review Solomon P Wasser
https://pubmed.ncbi.nlm.nih.gov/28605319
13. News articles 7 May 2024 Main cause of death for people under 65 years: cancer, Eurostat
https://ec.europa.eu/eurostat/web/products-eurostat-news/w/ddn-20240507-1
14. August 23, 2024 Cancer has replaced cardiovascular diseases as the leading cause of death in several wealthy countries, Our World in Data
https://ourworldindata.org/data-insights/cancer-has-replaced-cardiovascular-diseases-as-the-leading-cause-of-death-in-several-wealthy-countries
15. Chemotherapy Side Effects, May 15, 2025 American Cancer Society,
https://www.cancer.org/cancer/managing-cancer/treatment-types/chemotherapy/chemotherapy-side-effects.html
16. Mitchell, E., Pham, M.H., Clay, A. et al. The long-term effects of chemotherapy on normal blood cells. Nat Genet 57, 1684–1694 (2025). https://doi.org/10.1038/s41588-025-02234-x
https://www.nature.com/articles/s41588-025-02234-x
17. Bentharavithana J, Islam T, Xu B. Medicinal Mushrooms in Colon Cancer Therapy: Mechanisms of Action of Bioactive Compounds and Therapeutic Potential. Int J Mol Sci. 2025 May 31;26(11):5304. doi: 10.3390/ijms26115304. PMID: 40508113; PMCID: PMC12154085.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12154085/
18. Panda, S.K.; Sahoo, G.; Swain, S.S.; Luyten, W. Anticancer Activities of Mushrooms: A Neglected Source for Drug Discovery. Pharmaceuticals 2022, 15, 176. https://doi.org/10.3390/ph15020176
https://www.mdpi.com/1424-8247/15/2/176
19. Sudeshna Nandi, Rimpa Sikder, Sylvie Rapior, Stéphanie Arnould, Jesus Simal-Gandara, Krishnendu Acharya, A review for cancer treatment with mushroom metabolites through targeting mitochondrial signaling pathway: In vitro and in vivo evaluations, clinical studies and future prospects for mycomedicine, Fitoterapia, Volume 172, 2024, 105681, ISSN 0367-326X, https://doi.org/10.1016/j.fitote.2023.105681.
https://www.sciencedirect.com/science/article/pii/S0367326X23002563
20. Smith, J.E. & Rowan, Neil. (2002). Medicinal Mushrooms: Their Therapeutic Properties and Current Medical Usage with Special Emphasis on Cancer Treatments. University of Strathclyde, Cancer Research UK. iv and 253.
https://www.academia.edu/305933/Medicinal_Mushrooms_Their_therapeutic_properties_and_current_medical_usage_with_special_emphasis_on_cancer_treatments
21. Ahn WS, Kim DJ, Chae GT, Lee JM, Bae SM, Sin JI, Kim YW, Namkoong SE, Lee IP. Natural killer cell activity and quality of life were improved by consumption of a mushroom extract, Agaricus blazei Murill Kyowa, in gynecological cancer patients undergoing chemotherapy. Int J Gynecol Cancer. 2004 Jul-Aug;14(4):589-94. doi: 10.1111/j.1048-891X.2004.14403.x. PMID: 15304151.
https://www.international-journal-of-gynecological-cancer.com/article/S1048-891X(24)15045-1/pdf
22. Kodama N, Komuta K, Nanba H. Effect of Maitake (Grifola frondosa) D-Fraction on the activation of NK cells in cancer patients. J Med Food. 2003 Winter;6(4):371-7. doi: 10.1089/109662003772519949. PMID: 14977447.
https://pubmed.ncbi.nlm.nih.gov/14977447/
23. Kodama N, Komuta K, Nanba H. Can maitake MD-fraction aid cancer patients? Altern Med Rev. 2002 Jun;7(3):236-9. PMID: 12126464.
https://pubmed.ncbi.nlm.nih.gov/12126464/
24. TianX, Lun Z, Ito J.Clinical observation on treatment of acute non lymphocytic leukemia with Agaricus blazei. Lanzhou Med Coll 1994;20:169–171.
https://www.springboard4health.com/notebook/health_agaricus_6.html
25. Wesa KM, Cunningham-Rundles S, Klimek VM, Vertosick E, Coleton MI, Yeung KS, Lin H, Nimer S, Cassileth BR. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother. 2015 Feb;64(2):237-47. doi: 10.1007/s00262-014-1628-6. Epub 2014 Oct 29. PMID: 25351719; PMCID: PMC4317517.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4317517/
26. Jakopovic B, Horvatić A, Baranasic J, Car I, Oršolić N, Jakopovich I, Sedić M and Kraljević Pavelić S (2024) Proteomic study of medicinal mushroom extracts reveals antitumor mechanisms in an advanced colon cancer animal model via ribosomal biogenesis, translation, and metabolic pathways. Front. Pharmacol. 15:1475102. doi: 10.3389/fphar.2024.1475102
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1475102/full
27. De Silva, D.D., Rapior, S., Fons, F. et al. Medicinal mushrooms in supportive cancer therapies: an approach to anti-cancer effects and putative mechanisms of action. Fungal Diversity 55, 1–35 (2012). https://doi.org/10.1007/s13225-012-0151-3
https://link.springer.com/article/10.1007/s13225-012-0151-3
28. Park HJ. Current Uses of Mushrooms in Cancer Treatment and Their Anticancer Mechanisms. Int J Mol Sci. 2022 Sep 10;23(18):10502. doi: 10.3390/ijms231810502. PMID: 36142412; PMCID: PMC9504980.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9504980/
29. National Library of Medicine, International journal of medicinal mushrooms, 1999
https://pmc.ncbi.nlm.nih.gov/articles/PMC9504980/
30. Suprasert P, Apichartpiyakul C, Sakonwasun C, Nitisuwanraksa P, Phuackchantuck R (2015) A Randomized Double Blinded Study of Ganoderma Lucidum (Lingzhi) in Salvage Setting of Recurrent Gynecologic Cancer. Int J Cancer Clin Res 2:021. 10.23937/2378-3419/2/3/1021
https://clinmedjournals.org/articles/ijccr/international-journal-of-cancer-and-clinical-research-ijccr-2-021.php?jid=ijccr
31. Suprasert P, Apichartpiyakul C, Sakonwasun C, Nitisuwanraksa P, Phuackchantuck R. Clinical characteristics of gynecologic cancer patients who respond to salvage treatment with Lingzhi. Asian Pac J Cancer Prev. 2014;15(10):4193-6. doi: 10.7314/apjcp.2014.15.10.4193. PMID: 24935369.
https://journal.waocp.org/article_29222_26e3ad041a7015d9bdf15628e47929f3.pdf
32. Lin Z, Sun L. Antitumor Effect of Ganoderma (Lingzhi) Mediated by Immunological Mechanism and Its Clinical Application. Adv Exp Med Biol. 2019;1182:39-77. doi: 10.1007/978-981-32-9421-9_2. PMID: 31777014.
https://pubmed.ncbi.nlm.nih.gov/31777014/
33. Li X, He Y, Zeng P, Liu Y, Zhang M, Hao C, Wang H, Lv Z, Zhang L. Molecular basis for Poria cocos mushroom polysaccharide used as an antitumour drug in China. J Cell Mol Med. 2019 Jan;23(1):4-20. doi: 10.1111/jcmm.13564. Epub 2018 Nov 15. PMID: 30444050; PMCID: PMC6307810.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307810/
34. Chen MH, May BH, Zhou IW, Zhang AL, Xue CC. Integrative Medicine for Relief of Nausea and Vomiting in the Treatment of Colorectal Cancer Using Oxaliplatin-Based Chemotherapy: A Systematic Review and Meta-Analysis. Phytother Res. 2016 May;30(5):741-53. doi: 10.1002/ptr.5586. Epub 2016 Feb 23. PMID: 26912094.
https://pubmed.ncbi.nlm.nih.gov/26912094/
35. Chen M, May BH, Zhou IW, Sze DM, Xue CC, Zhang AL. Oxaliplatin-based chemotherapy combined with traditional medicines for neutropenia in colorectal cancer: A meta-analysis of the contributions of specific plants. Crit Rev Oncol Hematol. 2016 Sep;105:18-34. doi: 10.1016/j.critrevonc.2016.07.002. Epub 2016 Jul 7. PMID: 27497028.
https://pubmed.ncbi.nlm.nih.gov/27497028/
36. Chen M, May BH, Zhou IW, Xue CC, Zhang AL. FOLFOX 4 combined with herbal medicine for advanced colorectal cancer: a systematic review. Phytother Res. 2014 Jul;28(7):976-91. doi: 10.1002/ptr.5092. Epub 2013 Dec 17. PMID: 24343974.
https://pubmed.ncbi.nlm.nih.gov/24343974/
37. Mendes LC. Effective fuling (Poria Cocos) for the treatment of obesity? Int J Complement Alt Med. 2018;11(6):380-385. DOI: 10.15406/ijcam.2018.11.00430
https://medcraveonline.com/IJCAM/effective-fuling-poria-cocos-for-the-treatment-of-obesity.html
38. Goday A, Barneto I, García-Almeida JM, Blasco A, Lecube A, Grávalos C, Martínez de Icaya P, de las Peñas R, Monereo S, Vázquez L, Palacio JE, Pérez-Segura P. Obesity as a risk factor in cancer: A national consensus of the Spanish Society for the Study of Obesity and the Spanish Society of Medical Oncology. Clin Transl Oncol. 2015 Oct;17(10):763-71. doi: 10.1007/s12094-015-1306-y. Epub 2015 Jun 3. PMID: 26036853.
https://www.seom.org/seomcms/images/stories/recursos/ClinicalTranslationOncology2015.pdf
39. Vucenik I, Stains JP. Obesity and cancer risk: evidence, mechanisms, and recommendations. Ann N Y Acad Sci. 2012 Oct;1271(1):37-43. doi: 10.1111/j.1749-6632.2012.06750.x. PMID: 23050962; PMCID: PMC3476838.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3476838/
40. Li, Qiuhuaa,b; Wang, Yingc; Ren, Lud,∗; Liu, Zhaozhee,∗. Noncausal relationship between body weight and breast cancer based on bidirectional Mendelian randomization evidence. Oncology and Translational Medicine 10(5):p 245-251, October 2024. | DOI: 10.1097/ot9.0000000000000058
https://journals.lww.com/otm/fulltext/2024/10000/noncausal_relationship_between_body_weight_and.6.aspx#:~:text=Being%20overweight%20or%20obese%20increases%20the%20risk,types%20of%20cancer,%20including%20postmenopausal%20breast%20cancer.
41. Pati S, Irfan W, Jameel A, Ahmed S, Shahid RK. Obesity and Cancer: A Current Overview of Epidemiology, Pathogenesis, Outcomes, and Management. Cancers (Basel). 2023 Jan 12;15(2):485. doi: 10.3390/cancers15020485. PMID: 36672434; PMCID: PMC9857053.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9857053/
42. Zhou DH, Lin LZ. [Effect of Jinshuibao capsule on the immunological function of 36 patients with advanced cancer]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995 Aug;15(8):476-8. Chinese. PMID: 8580695.
https://pubmed.ncbi.nlm.nih.gov/8580695/
43. The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II. Zhu JS1, Halpern GM, Jones K., J Altern Complement Med. 1998 Winter;4(4):429-57.
https://pubmed.ncbi.nlm.nih.gov/9884180/
44. University of Oxford, Anti-cancer drug derived from fungus shows promise in clinical trials, 8 Oct 2021,
https://www.ox.ac.uk/news/2021-10-08-anti-cancer-drug-derived-fungus-shows-promise-clinical-trials
45. Cochrane Database Syst Rev, 2012, Ganoderma Lucidum (Reishi Mushroom) for Cancer Treatment, Xingzhong Jin, Julieta Ruiz Beguerie, Daniel Man-Yeun Sze, Godfrey C F Chan
https://pubmed.ncbi.nlm.nih.gov/22696372/
46. Cochrane Database Syst Rev, 4 (4), CD007731 2016 Apr 5 Ganoderma Lucidum (Reishi Mushroom) for Cancer Treatment Xingzhong Jin 1 , Julieta Ruiz Beguerie, Daniel Man-Yeun Sze, Godfrey C F Chan
https://europepmc.org/article/MED/27045603
47. Cao Y, Xu X, Liu S, Huang L, Gu J. Ganoderma: A Cancer Immunotherapy Review. Front Pharmacol. 2018 Oct 25;9:1217. doi: 10.3389/fphar.2018.01217. PMID: 30410443; PMCID: PMC6209820.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6209820
48. Review J Ethnopharmacol. 2020 Jun 3;260:113047. Online ahead of print. Ganoderma Lucidum: A Rational Pharmacological Approach to Surmount Cancer Md Faruque Ahmad
https://pubmed.ncbi.nlm.nih.gov/32504783/
49. Johnson BM, Doonan BP, Radwan FF, Haque A. Ganoderic Acid DM: An Alternative Agent for the Treatment of Advanced Prostate Cancer. Open Prost Cancer J. 2010 Jan 1;3:78-85. doi: 10.2174/1876822901003010078. PMID: 24790681; PMCID: PMC4002166.
https://pubmed.ncbi.nlm.nih.gov/24790681/
50. Zhao X, Zhou D, Liu Y, Li C, Zhao X, Li Y, Li W. Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway. Mol Med Rep. 2018 Jan;17(1):147-157. doi: 10.3892/mmr.2017.7904. Epub 2017 Oct 26. PMID: 29115463; PMCID: PMC5780085.
https://pubmed.ncbi.nlm.nih.gov/29115463/
51. Liu J, Shiono J, Shimizu K, Kukita A, Kukita T, Kondo R. Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2154-7. doi: 10.1016/j.bmcl.2009.02.119. Epub 2009 Mar 4. PMID: 19289282.
https://pubmed.ncbi.nlm.nih.gov/19289282/
52. Liang C, Tian D, Liu Y, Li H, Zhu J, Li M, Xin M, Xia J. Review of the molecular mechanisms of Ganoderma lucidum triterpenoids: Ganoderic acids A, C2, D, F, DM, X and Y. Eur J Med Chem. 2019 Jul 15;174:130-141. doi: 10.1016/j.ejmech.2019.04.039. Epub 2019 Apr 20. PMID: 31035236.
https://pubmed.ncbi.nlm.nih.gov/31035236/
53. Cizmarikova M. The Efficacy and Toxicity of Using the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), and Its Products in Chemotherapy (Review). Int J Med Mushrooms. 2017;19(10):861-877. doi: 10.1615/IntJMedMushrooms.2017024537. PMID: 29256841.
https://pubmed.ncbi.nlm.nih.gov/29256841/
54. ARBS Annual Review of Biomedical Sciences Antitumor Properties of Ganoderma lucidum Polysaccharides and Terpenoids, in Annual Review of Biomedical Sciences · January 2011, Marcela Camargo, Ramon Kaneno
www.researchgate.net/publication/232722630_ARBS_Annual_Review_of_Biomedical_Sciences_Antitumor_Properties_of_Ganoderma_lucidum_Polysaccharides_and_Terpenoids
55. Medicinal Mushrooms (PDQ®): Health Professional Version PDQ Integrative, Alternative, and Complementary Therapies Editorial Board In: PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002–. 2019 Oct 25.
https://pubmed.ncbi.nlm.nih.gov/27929633/
56. Mycotherapy of cancer: an update on cytotoxic and antitumor activities of mushrooms, bioactive principles and molecular mechanisms of their action. Popović V, Živković J, Davidović S, Stevanović M, Stojković D. Curr Top Med Chem. 2013.
https://pubmed.ncbi.nlm.nih.gov/24083788
57. Cancer without Pharmacological Illusions and a Niche for Mycotherapy (Review). Zmitrovich IV, Belova NV, Balandaykin ME, Bondartseva MA, Wasser SP5. Int J Med Mushrooms. 2019;21(2):105-119.
https://pubmed.ncbi.nlm.nih.gov/30806218/
58. Ganoderma lucidum: a potent pharmacological macrofungus. Sanodiya BS, Thakur GS, Baghel RK, Prasad GB, Bisen PS. Curr Pharm Biotechnol. 2009 Dec;10(8):717-42.
https://pubmed.ncbi.nlm.nih.gov/19939212
59. Integr Cancer Ther. 2015 May;14(3):249-57. doi: 10.1177/1534735414568721. Epub 2015 Jan 27. Ganoderma lucidum for cancer treatment: we are close but still not there. Cheng S1, Sliva D2.
https://pubmed.ncbi.nlm.nih.gov/25626896/
60. Exp Ther Med. 2017 Oct;14(4):3273-3278. doi: 10.3892/etm.2017.4883. Epub 2017 Aug 3. Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors. Zheng DS1, Chen LS2.
http://europepmc.org/article/MED/28912878
61. St. Jude, Biologically Active Ganoderma Lucidum Compounds and Synthesis of Derivatives and Probes
https://www.stjude.org/research/shared-resources/technology-licensing/technologies/biologically-active-ganoderma-lucidum-compounds-and-synthesis-of-derivatives-and-probes-sj-19-0035.html
62. https://hospitals.webometrics.info/en/world
63. Anticancer Agents Med Chem, 18 (5), 667-674 2018 Ganoderma Lucidum Polysaccharides as An Anti-cancer Agent Didem Sohretoglu, Shile Huang
https://pubmed.ncbi.nlm.nih.gov/29141563/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624854/
64. Do Mushroom Supplements Boost Immunity Against Cancer? By Susan Wagner Tuesday, October 22, 2024, Memorial Sloan Kettering Cancer Center
https://www.mskcc.org/news/do-mushroom-supplements-boost-immunity-against-cancer
65. Memorial Sloan Kettering Cancer Center, Tuesday, February 14, 2023, Shiitake Mushroom
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/shiitake-mushroom
66. Memorial Sloan Kettering Cancer Center, Tuesday, May 31, 2022, Coriolus versicolor
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/coriolus-versicolor
67. Memorial Sloan Kettering Cancer Center, Friday, May 13, 2022, Maitake
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/maitake
68. Memorial Sloan Kettering Cancer Center, Friday, February 4, 2022, Phellinus linteus
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/phellinus-linteus
69. Memorial Sloan Kettering Cancer Center, Thursday, February 10, 2022, Agaricus
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/agaricus
70. Memorial Sloan Kettering Cancer Center, Thursday, February 9, 2023, Reishi Mushroom
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/reishi-mushroom
71. Memorial Sloan Kettering Cancer Center, Monday, February 20, 2023, Chaga Mushroom
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/chaga-mushroom
72. Memorial Sloan Kettering Cancer Center, Wednesday, June 5, 2024, Lion's Mane Mushroom
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/lions-mane-mushroom
73. Memorial Sloan Kettering Cancer Center, Friday, July 8, 2022, Oyster mushroom
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/oyster-mushroom
74. Memorial Sloan Kettering Cancer Center, Thursday, February 10, 2022, Cordyceps
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/cordyceps
75. Memorial Sloan Kettering Cancer Center Ranked the Best Cancer Center in the Northeast and First in the Nation for Urology Care by U.S. News & World Report, Tuesday, August 1, 2023
https://www.mskcc.org/news-releases/mskcc-ranked-best-cancer-center-in-northeast-and-first-in-nation-for-urology-care-by-u-s-news-world-report
76. Immunol Invest, 2003, Effects of Ganopoly (A Ganoderma Lucidum Polysaccharide Extract) on the Immune Functions in Advanced-Stage Cancer Patients, Yihuai Gao, Shufeng Zhou, Wenqi Jiang, Min Huang, Xihu Dai
https://pubmed.ncbi.nlm.nih.gov/12916709/
77. Asian Pac J Cancer Prev, 15 (10), 4193-6 2014 Clinical Characteristics of Gynecologic Cancer Patients Who Respond to Salvage Treatment With Lingzhi Prapaporn Suprasert, Chatchawann Apichartpiyakul, Choompone Sakonwasun, Pimonphan Nitisuwanraksa, Rochana Phuackchantuck
https://pubmed.ncbi.nlm.nih.gov/24935369
78. “And What Other Medications Are You Taking?” John D. Gordan Wen-Yee Chay R. Kate Kelley , Andrew H. Ko Su-Pin Choo Alan P. Venook Show More, Journal of Clinical Oncology
https://ascopubs.org/doi/full/10.1200/jco.2010.32.8054?cited-by=yes&legid=jco%3B29%2F11%2Fe288
79. Hiroshima J Med Sci. 2010. A water-soluble extract from culture medium of Ganoderma lucidum mycelia suppresses the development of colorectal adenomas. Oka S, Tanaka S, Yoshida S, Hiyama T, Ueno Y, Ito M, Kitadai Y, Yoshihara M, Chayama K.
https://pubmed.ncbi.nlm.nih.gov/20518254/
80. Journal of Clinical Oncology, Volume 26, Issue 15, Randomized, double-blind and placebo-controlled study of the immunomodulatory effects of Lingzhi in children with cancers M. K. Shing, T. F. Leung, Y. L. Chu, C. Y. Li, K. W. Chik, P. C. LeungV. Lee, P. M. Yuen, C. K. Li
https://ascopubs.org/doi/abs/10.1200/jco.2008.26.15_suppl.14021
81. Int Immunopharmacol, 6 (3), 499-508 Mar 2006 Monitoring of Immune Responses to a Herbal Immuno-Modulator in Patients With Advanced Colorectal Cancer Xiao Chen, Ze-Ping Hu, Xiao-Xia Yang, Min Huang, Yihuai Gao, Wenbo Tang, Sui Yung Chan, Xihu Dai, Jinxian Ye, Paul Chi-Liu Ho, Wei Duan, Hong-Yuan Yang, Yi-Zhun Zhu, Shu-Feng Zhou
https://pubmed.ncbi.nlm.nih.gov/16428086/
82. Λέμφωμα μη Hodgkin (NHL), Lymphoma Australia
https://www.lymphoma.org.au/el/types-of-lymphoma/non-hodgkin-lymphoma/
83. Cheuk W, Chan JK, Nuovo G, Chan MK, Fok M. Regression of gastric large B-Cell lymphoma accompanied by a florid lymphoma-like T-cell reaction: immunomodulatory effect of Ganoderma lucidum (Lingzhi)? Int J Surg Pathol. 2007 Apr;15(2):180-6. doi: 10.1177/1066896906295890. PMID: 17478779.
https://pubmed.ncbi.nlm.nih.gov/17478779/
84. Hossain, Masud & Bhowmick, Sujan & Sarkar, Md Marzan & Basunia, Mafroz & Choudhury, Bazlul & Hossain, Shahdat. (2018). Effects of Ganoderma Lucidum on Palliative Care In Oral Squamous Cell Carcinoma (OSCC) Patients: An Evidence of Excellent Postoperative Support for Cancer Patients. IOSR Journal of Dental and Medical Sciences. 17. 10.9790/0853-1701107687.
https://www.researchgate.net/publication/322790454_Effects_of_Ganoderma_Lucidum_on_Palliative_Care_In_Oral_Squamous_Cell_Carcinoma_OSCC_Patients_An_Evidence_of_Excellent_Postoperative_Support_for_Cancer_Patients
85. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614. doi: 10.1155/2012/809614. Epub 2011 Dec 10. PMID: 22203880; PMCID: PMC3236089.
https://pubmed.ncbi.nlm.nih.gov/22203880/
86. Small Cell Lung Cancer vs. Non-small Cell Lung Cancer: What’s the Difference? National Foundation for Cancer Research, November 4, 2020
https://www.nfcr.org/blog/small-cell-lung-cancer-vs-non-small-cell-lung-cancer-whats-the-difference/
87. Zappa C, Mousa SA. Non-small cell lung cancer: current treatment and future advances. Transl Lung Cancer Res. 2016 Jun;5(3):288-300. doi: 10.21037/tlcr.2016.06.07. PMID: 27413711; PMCID: PMC4931124.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931124/
88. Treatment for lung cancer, national institutes for health and care excellence
https://www.nice.org.uk/about/what-we-do/into-practice/measuring-the-use-of-nice-guidance/impact-of-our-guidance/niceimpact-lung-cancer/ch4-treatment-for-lung-cancer
89. Niu FY, Zhou Q, Yang JJ, Zhong WZ, Chen ZH, Deng W, He YY, Chen HJ, Zeng Z, Ke EE, Zhao N, Zhang N, Sun HW, Zhang QY, Xie Z, Zhang XC, Wu YL. Distribution and prognosis of uncommon metastases from non-small cell lung cancer. BMC Cancer. 2016 Feb 24;16:149. doi: 10.1186/s12885-016-2169-5. PMID: 26911831; PMCID: PMC4766662.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4766662/
90. Hong, Y., Park, S. & Lee, M.K. The prognosis of non-small cell lung cancer patients according to endobronchial metastatic lesion. Sci Rep 12, 13588 (2022). https://doi.org/10.1038/s41598-022-17918-1
https://www.nature.com/articles/s41598-022-17918-1
91. Lung Cancer Survival Rates, American Cancer Society, January 29, 2024
https://www.cancer.org/cancer/types/lung-cancer/detection-diagnosis-staging/survival-rates.html
92. Clough W, Al Jaberi M, Dalia S. Non-small cell lung cancer with MET exon 14 skip mutation: case report. Ann Transl Med 2022;10(23):1287. doi: 10.21037/atm-2022-53
https://atm.amegroups.org/article/view/104773/html
93. National Cancer Institute at the National Institutes of Health, Non-Small Cell Lung Cancer Treatment (PDQ®)–Health Professional Version, June 21, 2024
https://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq
94. What is metastatic lung cancer? Cancer Research UK, 20 Mar 2023
https://www.cancerresearchuk.org/about-cancer/lung-cancer/metastatic/what-is
95. Gao Y., Dai X., Chen G., Ye J., Zhou S. A randomized, placebo-controlled, multicenter study of Ganoderma lucidum (W.Curt.:Fr.) Lloyd (Aphyllophoromycetideae) polysaccharides (Ganopoly) in patients with advanced lung cancer. Int. J. Med. Mushrooms. 2003;5:14. doi: 10.1615/InterJMedicMush.v5.i4.40
https://europepmc.org/article/MED/35215289
96. Cell Physiol Biochem. 2014. Protection against lung cancer patient plasma-induced lymphocyte suppression by Ganoderma lucidum polysaccharides. Sun LX1, Li WD, Lin ZB, Duan XS, Li XF, Yang N, Lan TF, Li M, Sun Y, Yu M, Lu J.
https://pubmed.ncbi.nlm.nih.gov/24525691/
97. Overview - Lung cancer, NHS, 01 November 2022
https://www.nhs.uk/conditions/lung-cancer/
98. Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024 May-Jun;74(3):229-263. doi: 10.3322/caac.21834. Epub 2024 Apr 4. PMID: 38572751.
https://acsjournals.onlinelibrary.wiley.com/doi/10.3322/caac.21834
99. Lung cancer, Mayo Clinic Staff
https://www.mayoclinic.org/diseases-conditions/lung-cancer/symptoms-causes/syc-20374620
100. 16 Unexpected Lung Cancer Symptoms You Should Know About, Rocky Mountain Cancer Centers
https://www.rockymountaincancercenters.com/blog/16-unexpected-signs-and-symptoms-of-lung-cancer
101. Types of lung cancer, 30 Dec 2022, Cancer Research UK
https://www.cancerresearchuk.org/about-cancer/lung-cancer/stages-types-grades/types
102. Key Statistics for Lung Cancer, January 29, 2024, American Cancer Society
https://www.cancer.org/cancer/types/lung-cancer/about/key-statistics.html
103. Xie A, Croce B, Tian DH. Smoking and lung cancer. Ann Cardiothorac Surg. 2014 Mar;3(2):221. doi: 10.3978/j.issn.2225-319X.2014.03.09. PMID: 24790854; PMCID: PMC3988304.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988304/
104. Lung Cancer Risk Factors, American Cancer Society, January 29, 2024
https://www.cancer.org/cancer/types/lung-cancer/causes-risks-prevention/risk-factors.html
105. Lung Cancer Treatment, The Johns Hopkins University
https://www.hopkinsmedicine.org/health/conditions-and-diseases/lung-cancer/lung-cancer-treatment
106. Clinical Trials, National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894, Shiitake
https://clinicaltrials.gov/search?cond=Shiitake&viewType=Card
107. Clinical Trials, National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894, coriolus versicolor
https://clinicaltrials.gov/search?cond=Coriolus%20versicolor%20&viewType=Card
108. Clinical Trials, National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894, Maitake
https://clinicaltrials.gov/search?cond=Maitake%20&viewType=Card
109. Clinical Trials, National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894, Agaricus
https://clinicaltrials.gov/search?cond=Agaricus%20&viewType=Card
110. Clinical Trials, National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894, Cordyceps
https://clinicaltrials.gov/search?cond=Cordyceps&viewType=Card
111. Clinical Trials, National Library of Medicine 8600 Rockville Pike, Bethesda, MD 20894, ganoderma
https://clinicaltrials.gov/search?cond=ganoderma&viewType=Card
112. Pasalioglu KB, Kaya H. Catheter indwell time and phlebitis development during peripheral intravenous catheter administration. Pak J Med Sci. 2014 Jul;30(4):725-30. PMID: 25097505; PMCID: PMC4121686.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121686/
113. Biswal SG, Mehta RD. Cutaneous adverse reactions of chemotherapy in cancer patients: A clinicoepidemiological study. Indian J Dermatol 2018;63:41-6
https://www.e-ijd.org/article.asp?issn=0019-5154;year=2018;volume=63;issue=1;spage=41;epage=46;aulast=Biswal
114. Tzolos E, Salawu A. Improving the frequency of visual infusion phlebitis (VIP) scoring on an oncology ward. BMJ Qual Improv Rep. 2014 Sep 12;3(1):u205455.w2364. doi: 10.1136/bmjquality.u205455.w2364. PMID: 26734282; PMCID: PMC4645857.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4645857/
115. Application Status of Phytotherapy for Prevention and Treatment of Chemotherapy Induced Phlebitis / 中国中医药信息杂志 Juan SHEN; Jing ZHANG; Weiwei YIN; Ligao WU. Chinese Journal of Information on Traditional Chinese Medicine ; (12): 134-136, 2016. Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wpr-489999
https://pesquisa.bvsalud.org/portal/resource/pt/wpr-489999
116. de Souza RGM, Schincaglia RM, Pimentel GD, Mota JF. Nuts and Human Health Outcomes: A Systematic Review. Nutrients. 2017 Dec 2;9(12):1311. doi: 10.3390/nu9121311. PMID: 29207471; PMCID: PMC5748761.
https://pubmed.ncbi.nlm.nih.gov/29207471
117. Falasca M, Casari I. Cancer chemoprevention by nuts: evidence and promises. Front Biosci (Schol Ed). 2012 Jan 1;4(1):109-20. doi: 10.2741/254. PMID: 22202046.
https://pubmed.ncbi.nlm.nih.gov/22202046/
118. Ros E, Singh A, O'Keefe JH. Nuts: Natural Pleiotropic Nutraceuticals. Nutrients. 2021 Sep 19;13(9):3269. doi: 10.3390/nu13093269. PMID: 34579146; PMCID: PMC8468443.
https://pubmed.ncbi.nlm.nih.gov/34579146
119. Falasca M, Casari I, Maffucci T. Cancer chemoprevention with nuts. J Natl Cancer Inst. 2014 Sep 10;106(9):dju238. doi: 10.1093/jnci/dju238. PMID: 25210199.
https://pubmed.ncbi.nlm.nih.gov/25210199/
120. Zhang D, Dai C, Zhou L, Li Y, Liu K, Deng YJ, Li N, Zheng Y, Hao Q, Yang S, Song D, Wu Y, Zhai Z, Cao S, Dai Z. Meta-analysis of the association between nut consumption and the risks of cancer incidence and cancer-specific mortality. Aging (Albany NY). 2020 Jun 2;12(11):10772-10794. doi: 10.18632/aging.103292. Epub 2020 Jun 2. PMID: 32487780; PMCID: PMC7346045.
https://pubmed.ncbi.nlm.nih.gov/32487780/
121. Naghshi S, Sadeghian M, Nasiri M, Mobarak S, Asadi M, Sadeghi O. Association of Total Nut, Tree Nut, Peanut, and Peanut Butter Consumption with Cancer Incidence and Mortality: A Comprehensive Systematic Review and Dose-Response Meta-Analysis of Observational Studies. Adv Nutr. 2021 Jun 1;12(3):793-808. doi: 10.1093/advances/nmaa152. PMID: 33307550; PMCID: PMC8166551.
https://pubmed.ncbi.nlm.nih.gov/33307550/
122. Bauer J, Morley JE, Schols AMWJ, Ferrucci L, Cruz-Jentoft AJ, Dent E, Baracos VE, Crawford JA, Doehner W, Heymsfield SB, Jatoi A, Kalantar-Zadeh K, Lainscak M, Landi F, Laviano A, Mancuso M, Muscaritoli M, Prado CM, Strasser F, von Haehling S, Coats AJS, Anker SD. Sarcopenia: A Time for Action. An SCWD Position Paper. J Cachexia Sarcopenia Muscle. 2019 Oct;10(5):956-961. doi: 10.1002/jcsm.12483. Epub 2019 Sep 15. PMID: 31523937; PMCID: PMC6818450.
https://pubmed.ncbi.nlm.nih.gov/31523937/
123. Nipp RD, Fuchs G, El-Jawahri A, Mario J, Troschel FM, Greer JA, Gallagher ER, Jackson VA, Kambadakone A, Hong TS, Temel JS, Fintelmann FJ. Sarcopenia Is Associated with Quality of Life and Depression in Patients with Advanced Cancer. Oncologist. 2018 Jan;23(1):97-104. doi: 10.1634/theoncologist.2017-0255. Epub 2017 Sep 21. PMID: 28935775; PMCID: PMC5759817.
https://pubmed.ncbi.nlm.nih.gov/28935775/
124. Aversa Z, Costelli P, Muscaritoli M. Cancer-induced muscle wasting: latest findings in prevention and treatment. Ther Adv Med Oncol. 2017 May;9(5):369-382. doi: 10.1177/1758834017698643. Epub 2017 Mar 8. PMID: 28529552; PMCID: PMC5424865.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5424865/
125. “Cancer Cachexia: After Years of No Advances, Progress Looks Possible was originally published by the National Cancer Institute.”, August 23, 2022
https://www.cancer.gov/about-cancer/treatment/research/cachexia
126. Nutrition for People Living with Cancer, Cancer Council Australia, 2022
https://www.cancer.org.au/assets/pdf/nutrition-and-cancer-booklet
127. British Nutrition Foundation, Protein, June 2021
https://www.nutrition.org.uk/healthy-sustainable-diets/protein/?level=Health%20professional
128. Protein: What you need to know, British Heart Foundation
https://www.bhf.org.uk/informationsupport/heart-matters-magazine/nutrition/protein
129. DRI Calculator Results, National Agricultural Library U.S. Department of Agriculture Secondary
https://www.nal.usda.gov/human-nutrition-and-food-safety/dri-calculator/results
130. Capitão C, Coutinho D, Neves PM, Capelas ML, Pimenta NM, Santos T, Mäkitie A, Ravasco P. Protein intake and muscle mass maintenance in patients with cancer types with high prevalence of sarcopenia: a systematic review. Support Care Cancer. 2022 Apr;30(4):3007-3015. doi: 10.1007/s00520-021-06633-8. Epub 2021 Oct 25. PMID: 34697674.
https://pubmed.ncbi.nlm.nih.gov/34697674
131. Integr Cancer Ther, 2 (4), 358-64 Dec 2003 Ganoderma Lucidum (Reishi) in Cancer Treatment Daniel Sliva
https://pubmed.ncbi.nlm.nih.gov/14713328/
https://www.researchgate.net/publication/8928055_Ganoderma_Lucidum_Reishi_in_Cancer_Treatment
132. Ahmad MF, Ahmad FA, Khan MI, Alsayegh AA, Wahab S, Alam MI, Ahmed F. Ganoderma lucidum: A potential source to surmount viral infections through β-glucans immunomodulatory and triterpenoids antiviral properties. Int J Biol Macromol. 2021 Sep 30;187:769-779. doi: 10.1016/j.ijbiomac.2021.06.122. Epub 2021 Jun 29. PMID: 34197853.
https://pubmed.ncbi.nlm.nih.gov/34197853/
133. Singh A, Saini RK, Kumar A, Chawla P, Kaushik R. Mushrooms as Nutritional Powerhouses: A Review of Their Bioactive Compounds, Health Benefits, and Value-Added Products. Foods. 2025 Feb 22;14(5):741. doi: 10.3390/foods14050741. PMID: 40077445; PMCID: PMC11899115.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11899115/
134. Yogesh Kumar, Baojun Xu, Bioactive compounds, health benefits, and practical applications of edible mushroom Schizophyllum commune Fr.: A decade-long critical review, Food Chemistry, Volume 492, Part 3, 2025, 145583, ISSN 0308-8146, https://doi.org/10.1016/j.foodchem.2025.145583.
https://www.sciencedirect.com/science/article/abs/pii/S0308814625028341
135. Hazarika DJ, Amao JA, Boro RC and Venturella G (2025) Editorial: Mushrooms as functional foods and nutraceuticals. Front. Sustain. Food Syst. 9:1622356. doi: 10.3389/fsufs.2025.1622356
https://www.frontiersin.org/journals/sustainable-food-systems/articles/10.3389/fsufs.2025.1622356/full
136. Mushrooms in Food Industry and Human Nutrition This special issue belongs to the section “Plant Foods“.
https://www.mdpi.com/journal/foods/special_issues/6955O6B643
137. Olusola Ogidi, Clement, Victor Olusegun Oyetayo, and Bamidele Juliet Akinyele. 2020. ‘Wild Medicinal Mushrooms: Potential Applications in Phytomedicine and Functional Foods’. An Introduction to Mushroom. IntechOpen. doi:10.5772/intechopen.90291.
https://www.intechopen.com/chapters/70347
138. Hsu, KD., Cheng, KC. From nutraceutical to clinical trial: frontiers in Ganoderma development. Appl Microbiol Biotechnol 102, 9037–9051 (2018). https://doi.org/10.1007/s00253-018-9326-5
https://link.springer.com/article/10.1007/s00253-018-9326-5
139. Boh B. Ganoderma lucidum: a potential for biotechnological production of anti-cancer and immunomodulatory drugs. Recent Pat Anticancer Drug Discov. 2013 Sep;8(3):255-87. doi: 10.2174/1574891x113089990036. PMID: 23227951.
https://pubmed.ncbi.nlm.nih.gov/23227951
140. Saltarelli R, Palma F, Gioacchini AM, Calcabrini C, Mancini U, De Bellis R, Stocchi V, Potenza L. Phytochemical composition, antioxidant and antiproliferative activities and effects on nuclear DNA of ethanolic extract from an Italian mycelial isolate of Ganoderma lucidum. J Ethnopharmacol. 2019 Mar 1;231:464-473. doi: 10.1016/j.jep.2018.11.041. Epub 2018 Dec 1. PMID: 30513345.
https://pubmed.ncbi.nlm.nih.gov/30513345/
141. Chugh RM, Mittal P, Mp N, Arora T, Bhattacharya T, Chopra H, Cavalu S, Gautam RK. Fungal Mushrooms: A Natural Compound With Therapeutic Applications. Front Pharmacol. 2022 Jul 13;13:925387. doi: 10.3389/fphar.2022.925387. PMID: 35910346; PMCID: PMC9328747.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9328747/
142. Adaptogenic or Medicinal Mushrooms, Published April 20, 2009, M. Saljoughian, PharmD, PhD Alta Bates Summit Medical Center Department of Pharmacy Services Berkeley, California,
https://www.uspharmacist.com/article/adaptogenic-or-medicinal-mushrooms
143. Adaptogens, Cleveland Clinic, Last reviewed on 02/10/2022.
https://my.clevelandclinic.org/health/drugs/22361-adaptogens
144. What are adaptogens and should you be taking them? February 16, 2022 By uclahealth,
https://www.uclahealth.org/news/article/what-are-adaptogens-and-should-you-be-taking-them
145. Medicinal Mushrooms and their history of therapeutic uses, Sophie Barrett, Medical Herbalist, Naturopath, Faculty of Homeopathy
https://www.facultyofhomeopathy.org/events/medicinal-mushrooms-their-history-of-therapeutic-uses
146. Pharmaceuticals (Basel) . 2020 Aug 29;13(9):E224. doi: 10.3390/ph13090224. Ganoderma lucidum Ethanol Extracts Enhance Re-Epithelialization and Prevent Keratinocytes from Free-Radical Injury Mario Abate, Giacomo Pepe, Rosario Randino, Simona Pisanti, Manuela Giovanna Basilicata, Verdiana Covelli, Maurizio Bifulco, Walter Cabri, Anna Maria D'Ursi, Pietro Campiglia, Manuela Rodriquez
https://pubmed.ncbi.nlm.nih.gov/32872510/
147. Bocharova OA. Adaptogeny kak sredstva profilakticheskoĭ onkologii [Adaptogens as agents for prophylactic oncology]. Vestn Ross Akad Med Nauk. 1999;(5):49-53. Russian. PMID: 10394302.
https://pubmed.ncbi.nlm.nih.gov/10394302/
148. Bocharova OA. Adaptogeny kak sredstva profilakticheskoĭ onkologii [Adaptogens as agents for prophylactic oncology]. Vestn Ross Akad Med Nauk. 1999;(5):49-53. Russian. PMID: 10394302.
https://pubmed.ncbi.nlm.nih.gov/10394302/
149. Peng H, Zhong L, Cheng L, Chen L, Tong R, Shi J, Bai L. Ganoderma lucidum: Current advancements of characteristic components and experimental progress in anti-liver fibrosis. Front Pharmacol. 2023 Jan 9;13:1094405. doi: 10.3389/fphar.2022.1094405. PMID: 36703748; PMCID: PMC9872944.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9872944/
150. Sinaeve, S.; Husson, C.; Antoine, M.-H.; Welti, S.; Stévigny, C.; Nortier, J. Nephroprotective Effects of Two Ganoderma Species Methanolic Extracts in an In Vitro Model of Cisplatin Induced Tubulotoxicity. J. Fungi 2022, 8, 1002. https://doi.org/10.3390/jof8101002
https://www.mdpi.com/2309-608X/8/10/1002?type=check_update&version=1
151. Xin, Qi-Hang & Luo, Qi & Wu, Ze-Hong & Zhang, Jiaojiao & Liu, Li-Zhong & Cheng, Yong-Xian. (2019). New Unsaturated Lactones and a Meroterpenoid from Ganoderma lucidum. Natural Product Communications. 14. 1934578X1985881. 10.1177/1934578X19858815.
https://journals.sagepub.com/doi/pdf/10.1177/1934578X19858815
152. Wang L, Li JQ, Zhang J, Li ZM, Liu HG, Wang YZ. Traditional uses, chemical components and pharmacological activities of the genus Ganoderma P. Karst.: a review. RSC Adv. 2020 Nov 18;10(69):42084-42097. doi: 10.1039/d0ra07219b. PMID: 35516772; PMCID: PMC9057998.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057998/
153. Rahman, Mohammad & Hossain, Shahdat & Abdullah, Noorlidah & Aminudin, Norhaniza. (2020). Ganoderma Lucidum Modulates Neuronal Structure and Function Regulatory Protein Expression and Protein-protein Interaction in Alzheimer's Disease Model Animals. 10.21203/rs.3.rs-104135/v1.
https://www.researchgate.net/publication/346006438_Ganoderma_Lucidum_Modulates_Neuronal_Structure_and_Function_Regulatory_Protein_Expression_and_Protein-protein_Interaction_in_Alzheimer%27s_Disease_Model_Animals
154. Interim Revision Announcement Official March 1, 2015, Ganoderma Lucidum Fruiting Body
https://www.uspnf.com/sites/default/files/usp_pdf/EN/USPNF/ganoderma_lucidum_fruiting_body.pdf
155. Herbal Medicines Compendium, Monographs » Final Authorized » Ganoderma lucidum Fruiting Body
https://hmc.usp.org/monographs/ganoderma-lucidum-fruiting-body-1-0
156. Ma Y, Zhang Q, Zhang Q, He H, Chen Z, Zhao Y, Wei D, Kong M, Huang Q. Improved production of polysaccharides in Ganoderma lingzhi mycelia by plasma mutagenesis and rapid screening of mutated strains through infrared spectroscopy. PLoS One. 2018 Sep 21;13(9):e0204266. doi: 10.1371/journal.pone.0204266. PMID: 30240407; PMCID: PMC6150529.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6150529/
157. Lindequist U. The merit of medicinal mushrooms from a pharmaceutical point of view. Int J Med Mushrooms. 2013;15(6):517-23. doi: 10.1615/intjmedmushr.v15.i6.10. PMID: 24266376.
https://pubmed.ncbi.nlm.nih.gov/24266376/
158. Wang, Mei and Gerhard Franz. “The role of the European Pharmacopoeia (Ph Eur) in quality control of traditional Chinese herbal medicine in European member states.” Traditional Chinese Medicine 1 (2015): 5-15.
https://epub.uni-regensburg.de/41675/1/The_Role_of_the_European_Pharmacopoeia_Ph_Eur_in_Q%281%29.pdf
159. University of Thessaly Institutional Repository, Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ), Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. Pharmaceutical mushrooms: Ganoderma lucidum, Karalia D., Graikou K., Gortzi O., Chinou I. , 2020
https://ir.lib.uth.gr/xmlui/handle/11615/74387
160. Council of Europe, European Directorate for the Quality of Medicines & HealthCare Newsroom Pharmeuropa issue 30.3 is complete. Comments before 30 September 2018
https://www.edqm.eu/en/-/pharmeuropa-issue-30.3-is-complete.-comments-before-30-september-2018-2
161. EUROPEAN PHARMACOPOEIA 11.0, Ganoderma lucidum
https://www.edqm.eu/documents/52006/467983/Latin+index+-+Ph.+Eur.+11.pdf/c7cbe840-9aed-05af-e2da-8faf69aedd82?t=1656599780218
162. Gurovic MSV, Viceconte FR, Pereyra MT, Bidegain MA, Cubitto MA. DNA damaging potential of Ganoderma lucidum extracts. J Ethnopharmacol. 2018 May 10;217:83-88. doi: 10.1016/j.jep.2018.02.005. Epub 2018 Feb 6. PMID: 29421594.
https://www.sciencedirect.com/science/article/abs/pii/S0378874117346895
163. Front Pharmacol. 2020 Apr 7;11:422. doi: 10.3389/fphar.2020.00422. eCollection 2020. Herbal Medicine for Cardiovascular Diseases: Efficacy, Mechanisms, and Safety Abdullah Shaito, Duong Thi Bich Thuan, Hoa Thi Phu, Thi Hieu Dung Nguyen, Hiba Hasan, Sarah Halabi, Samar Abdelhady, Gheyath K Nasrallah, Ali H Eid, Gianfranco Pintus
http://europepmc.org/article/MED/32317975
164. Paterson RR. Ganoderma - a therapeutic fungal biofactory. Phytochemistry. 2006 Sep;67(18):1985-2001. doi: 10.1016/j.phytochem.2006.07.004. Epub 2006 Aug 14. PMID: 16905165.
https://pubmed.ncbi.nlm.nih.gov/16905165
165. Sheinfeld Gorin S, Krebs P, Badr H, et al. Meta-analysis of psychosocial interventions to reduce pain in patients with cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 2012 Feb;30(5):539-547. DOI: 10.1200/jco.2011.37.0437. PMID: 22253460; PMCID: PMC6815997.
https://europepmc.org/article/PMC/6815997
166. Deng G. Integrative Medicine Therapies for Pain Management in Cancer Patients. Cancer Journal (Sudbury, Mass.). 2019 Sep/Oct;25(5):343-348. DOI: 10.1097/ppo.0000000000000399. PMID: 31567462; PMCID: PMC6777858.
https://europepmc.org/article/MED/31567462
167. Yang J, Wahner-Roedler DL, Zhou X, et al. Acupuncture for palliative cancer pain management: systematic review. BMJ Supportive & Palliative Care. 2021 Sep;11(3):264-270. DOI: 10.1136/bmjspcare-2020-002638. PMID: 33441387; PMCID: PMC8380897.
https://europepmc.org/article/MED/33441387
168. The analgesic effect of several edible mushrooms, H Wang†, Y Liu†, C Han*, OA Alternative Medicine
https://scispace.com/pdf/the-analgesic-effect-of-several-edible-mushrooms-2mascj4oc1.pdf
169. Elkhateeb, Waill & Elghwas, Dina & Daba, Ghoson. (2023). Anti-Inflammatory agents from Mushrooms: A Review. Open Access Journal of Pharmaceutical Research. 7. 1-7. 10.23880/oajpr-16000278.
https://medwinpublishers.com/OAJPR/anti-inflammatory-agents-from-mushrooms-a-review.pdf
170. Moazzem Hossen SM, Hossain MS, Akbar S, Tahmida U, Mawa J, Uddin Emon N. Wild mushrooms showed analgesic and cytotoxic properties along with phytoconstituent's binding affinity to COX-1, COX-2 and cytochrome P450 2C9. Heliyon. 2021 Sep 14;7(9):e07997. doi: 10.1016/j.heliyon.2021.e07997. PMID: 34585013; PMCID: PMC8455681.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8455681/
171. Fhernanda R. Smiderle, Lorena M. Olsen, Elaine R. Carbonero, Cristiane H. Baggio, Cristina S. Freitas, Rodrigo Marcon, Adair R.S. Santos, Philip A.J. Gorin, Marcello Iacomini, Anti-inflammatory and analgesic properties in a rodent model of a (1→3),(1→6)-linked β-glucan isolated from Pleurotus ulmonarius, European Journal of Pharmacology, Volume 597, Issues 1–3, 2008, Pages 86-91, ISSN 0014-2999, https://doi.org/10.1016/j.ejphar.2008.08.028.
https://www.sciencedirect.com/science/article/abs/pii/S0014299908009059?via%3Dihub
172. Ede, Samuel O. et al. “ANALGESIC AND ANTI INFLAMMATORY ACTIVITIES OF THE ETHANOLIC EXTRACT OF THE MUSHROOM GANODERMA APPLANATUM.” (2012).
https://scispace.com/pdf/analgesic-and-anti-inflammatory-activities-of-the-ethanolic-1ie5fqee1e.pdf
173. Pigoń-Zając, D.; Małecka-Massalska, T.; Łapiński, J.; Prendecka-Wróbel, M. Modern Pro-Health Applications of Medicinal Mushrooms: Insights into the Polyporaceae Family, with a Focus on Cerrena unicolor. Molecules 2025, 30, 4089. https://doi.org/10.3390/molecules30204089
https://www.mdpi.com/1420-3049/30/20/4089
174. Ahmad MF. Ganoderma lucidum: Persuasive biologically active constituents and their health endorsement. Biomed Pharmacother. 2018 Nov;107:507-519. doi: 10.1016/j.biopha.2018.08.036. Epub 2018 Aug 13. PMID: 30114634.
https://pubmed.ncbi.nlm.nih.gov/30114634/
175. Cui X, Zhang Y. Neuropharmacological Effect and Clinical Applications of Ganoderma (Lingzhi). Adv Exp Med Biol. 2019;1182:143-157. doi: 10.1007/978-981-32-9421-9_5. PMID: 31777017.
https://pubmed.ncbi.nlm.nih.gov/31777017/
176. Jinangi Bentharavithana, Jinhai Luo, Baojun Xu, Critical review on signaling pathways of immune boosting effects of edible and medicinal mushrooms, Journal of Future Foods, 2026, , ISSN 2772-5669, https://doi.org/10.1016/j.jfutfo.2026.01.022.
https://www.sciencedirect.com/science/article/pii/S2772566926000406
177. Zhao S, Gao Q, Rong C, Wang S, Zhao Z, Liu Y, Xu J. Immunomodulatory Effects of Edible and Medicinal Mushrooms and Their Bioactive Immunoregulatory Products. J Fungi (Basel). 2020 Nov 8;6(4):269. doi: 10.3390/jof6040269. PMID: 33171663; PMCID: PMC7712035.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7712035/
178. Yang J-y, Tao L, Lou D, Patabendige NM, Ediriweera AN, Liu S, Lu W, Tarafder E, Rapior S and Hapuarachchi KK (2025) Innovative applications of medicinal mushrooms in functional foods and nutraceuticals: a focus on health-boosting beverages. Front. Cell. Infect. Microbiol. 15:1605301. doi: 10.3389/fcimb.2025.1605301
https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2025.1605301/full
179. 8 November 2019, Mushroom extracts could offer an immune cell boost, Griffith University
https://news.griffith.edu.au/2019/11/08/mushroom-extracts-could-offer-an-immune-cell-boost/
180. Ren L, Zhang J, Zhang T. Immunomodulatory activities of polysaccharides from Ganoderma on immune effector cells. Food Chem. 2021 Mar 15;340:127933. doi: 10.1016/j.foodchem.2020.127933. Epub 2020 Aug 26. PMID: 32882476.
https://pubmed.ncbi.nlm.nih.gov/32882476/
181. Wang X, Lin Z. Immunomodulating Effect of Ganoderma (Lingzhi) and Possible Mechanism. Adv Exp Med Biol. 2019;1182:1-37. doi: 10.1007/978-981-32-9421-9_1. PMID: 31777013.
https://pubmed.ncbi.nlm.nih.gov/31777013/
182. Klaunig JE. Oxidative Stress and Cancer. Curr Pharm Des. 2018;24(40):4771-4778. doi: 10.2174/1381612825666190215121712. PMID: 30767733.
https://pubmed.ncbi.nlm.nih.gov/30767733/
183. Ruth W. Mwangi, John M. Macharia, Isabel N. Wagara, Raposa L. Bence, The antioxidant potential of different edible and medicinal mushrooms, Biomedicine & Pharmacotherapy, Volume 147, 2022, 112621, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2022.112621. (https://www.sciencedirect.com/science/article/pii/S0753332222000099)
https://www.sciencedirect.com/science/article/pii/S0753332222000099
184. Podkowa, A., Kryczyk-Poprawa, A., Opoka, W. et al. Culinary–medicinal mushrooms: a review of organic compounds and bioelements with antioxidant activity. Eur Food Res Technol 247, 513–533 (2021). https://doi.org/10.1007/s00217-020-03646-1
https://link.springer.com/article/10.1007/s00217-020-03646-1
185. Ferreira, Isabel & Barros, Lillian & Abreu, Rui. (2009). Antioxidants in Wild Mushrooms. Current Medicinal Chemistry. 16. 1543-1560. 10.2174/092986709787909587.
https://www.researchgate.net/publication/267036608_Antioxidants_in_Wild_Mushrooms
186. Cör D, Knez Ž, Knez Hrnčič M. Antitumour, Antimicrobial, Antioxidant and Antiacetylcholinesterase Effect of Ganoderma Lucidum Terpenoids and Polysaccharides: A Review. Molecules. 2018 Mar 13;23(3):649. doi: 10.3390/molecules23030649. PMID: 29534044; PMCID: PMC6017764.
https://pubmed.ncbi.nlm.nih.gov/29534044/
187. Seweryn E, Ziała A, Gamian A. Health-Promoting of Polysaccharides Extracted from Ganoderma lucidum. Nutrients. 2021 Aug 7;13(8):2725. doi: 10.3390/nu13082725. PMID: 34444885; PMCID: PMC8400705.
https://pubmed.ncbi.nlm.nih.gov/34444885/
188. Kladar NV, Gavarić NS, Božin BN. Ganoderma: insights into anticancer effects. Eur J Cancer Prev. 2016 Sep;25(5):462-71. doi: 10.1097/CEJ.0000000000000204. PMID: 26317382.
https://pubmed.ncbi.nlm.nih.gov/26317382/
189. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002 Dec 19-26;420(6917):860-7. doi: 10.1038/nature01322. PMID: 12490959; PMCID: PMC2803035.
https://pubmed.ncbi.nlm.nih.gov/12490959/
190. Diakos CI, Charles KA, McMillan DC, Clarke SJ. Cancer-related inflammation and treatment effectiveness. Lancet Oncol. 2014 Oct;15(11):e493-503. doi: 10.1016/S1470-2045(14)70263-3. PMID: 25281468.
https://pubmed.ncbi.nlm.nih.gov/25281468/
191. Elinav E, Nowarski R, Thaiss CA, Hu B, Jin C, Flavell RA. Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer. 2013 Nov;13(11):759-71. doi: 10.1038/nrc3611. PMID: 24154716.
https://pubmed.ncbi.nlm.nih.gov/24154716/
192. Bin Du, Fengmei Zhu, Baojun Xu, An insight into the anti-inflammatory properties of edible and medicinal mushrooms, Journal of Functional Foods, Volume 47, 2018, Pages 334-342, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2018.06.003.
https://www.sciencedirect.com/science/article/abs/pii/S1756464618302998
193. Xiaoying M, Peng Z, Hong W, Na G, Jun X, Ying Z, Xun C and Guoli L (2025) From functional foods to immunotherapeutic agents: mechanistic insights into medicinal mushroom bioactives in chronic inflammation management. Front. Nutr. 12:1725297. doi: 10.3389/fnut.2025.1725297
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1725297/full
194. Mori, K., Ouchi, K., & Hirasawa, N. (2015). The anti-inflammatory effects of lion’s mane culinary-medicinal mushroom, Hericium Erinaceus (Higher basidiomycetes) in a coculture system of 3T3-L1 adipocytes and RAW264 macrophages. International Journal of Medicinal Mushrooms, 17(7), 609-618. https://doi.org/10.1615/IntJMedMushrooms.v17.i7.10
https://tohoku.elsevierpure.com/en/publications/the-anti-inflammatory-effects-of-lions-mane-culinary-medicinal-mu/
195. Veerapagu, M., Anandi, A.A., Jeya, K.R., Sankara Narayanan, A. (2026). Anti-Inflammatory Activity of Medicinal Mushrooms. In: Narayanan, A.S., Dharumadurai, D. (eds) Medicinal Mushrooms. Springer Protocols Handbooks. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-4993-0_20
https://link.springer.com/protocol/10.1007/978-1-0716-4993-0_20#citeas
196. Masashi Mizuno, Ken-ichiro Minato, Anti-inflammatory and immunomodulatory properties of polysaccharides in mushrooms, Current Opinion in Biotechnology, Volume 86, 2024, 103076, ISSN 0958-1669, https://doi.org/10.1016/j.copbio.2024.103076.
https://www.sciencedirect.com/science/article/abs/pii/S0958166924000120
197. Geng Y, Zhu S, Lu Z, Xu H, Shi JS, Xu ZH. Anti-inflammatory activity of mycelial extracts from medicinal mushrooms. Int J Med Mushrooms. 2014;16(4):319-25. doi: 10.1615/intjmedmushrooms.v16.i4.20. PMID: 25271860.
https://www.dl.begellhouse.com/journals/708ae68d64b17c52,4c99b516238143af,0b6528d9687446ed.html
198. Geng X, Zhong D, Su L, Lin Z, Yang B. Preventive and therapeutic effect of Ganoderma lucidum on kidney injuries and diseases. Adv Pharmacol. 2020;87:257-276. doi: 10.1016/bs.apha.2019.10.003. Epub 2019 Nov 20. PMID: 32089235.
https://pubmed.ncbi.nlm.nih.gov/32089235/
199. Yin Z, Yang B, Ren H. Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Skin Diseases and Care. Adv Exp Med Biol. 2019;1182:311-321. doi: 10.1007/978-981-32-9421-9_14. PMID: 31777026.
https://pubmed.ncbi.nlm.nih.gov/31777026/
200. Bhardwaj N, Katyal P, Sharma AK. Suppression of inflammatory and allergic responses by pharmacologically potent fungus Ganoderma lucidum. Recent Pat Inflamm Allergy Drug Discov. 2014;8(2):104-17. doi: 10.2174/1872213x08666140619110657. PMID: 24948193.
https://pubmed.ncbi.nlm.nih.gov/24948193/
201. István Zupkó, Walter Jaeger, Zeki Topcu, Chin-Chung Wu, "Anticancer Properties of Natural Products", BioMed Research International, vol. 2015, Article ID 242070, 2 pages, 2015. https://doi.org/10.1155/2015/242070
https://www.hindawi.com/journals/bmri/2015/242070/
202. Xiao Z, Morris-Natschke SL, Lee KH. Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates. Medicinal Research Reviews. 2016 Jan;36(1):32-91. DOI: 10.1002/med.21377. PMID: 26359649; PMCID: PMC4679534.
https://europepmc.org/article/MED/26359649
203. Καλλιέργεια φαρμακευτικών μανιταριών από το Εργαστήριο Μικροβιολογίας και Βιοτεχνολογίας Τροφίμων του ΤΕΙ Θεσσαλίας,
https://www.in.gr/2019/01/26/health/health-news/kalliergeia-farmakeytikon-manitarion-apo-tei-thessalias/
204. Ινστιτούτο Τεχνολογίας Γεωργικών Προϊόντων (I.ΤΕ.ΓΕ.Π)
https://itap.com.gr/edodimon-mykiton-2
205. Πανεπιστήμιο Θεσσαλίας, Τμήμα Ιατρικής, Διπλωματική Εργασία, ΑΙ Χονδρού.
206. Χαροκόπειο Πανεπιστήμιο, Τµήµα Επιστήµης ∆ιαιτολογίας, Πτυχιακή Μελέτη, Ανίχνευση πιθανής πρεβιοτικής δράσης σε µύκητες του γένους Ganoderma, Ροηλίδη Αθανασία
http://estia.hua.gr/browse/17261
207. Εθνικό Μετσόβιο Πολυτεχνείο, Σχολή Χημικών Μηχανικών, Απομόνωση και αξιολόγηση πρωτεϊνικών και υδατανθρακικών συστατικών μανιταριών, Διπλωματική Εργασία, Τσαλτάκη Χρυσούλα
208. Πανεπιστήμιο Αιγαίου, Τμήμα Επιστήμης Τροφίμων και Διατροφής, Πτυχιακή Εργασία, Ο ρόλος της διατροφής στην πρόληψη του καρκίνου, Καρυωτάκη Στυλιανή,
209. Χαροκόπειο Πανεπιστήμιο, Ανίχνευση πιθανής πρεβιοτικής δράσης σε βασιδιομύκητες. Πτυχιακή εργασία, Σεκκίδου, Μικαέλα
https://www.openarchives.gr/aggregator-openarchives/edm/estia/000015-15662/view
210. Γεωπονικό Πανεπιστήμιο Αθηνών, Μεταπτυχιακή εργασία, Μελέτη της βιοδραστικότητας εκχυλισμάτων μυκηλίου και καρποσωμάτων μυκήτων του γένους Ganoderma, Ευσταθιάδου Ευδοξία
https://www.openarchives.gr/aggregator-openarchives/edm/aua/000039-10329_6463
211. ΑΤΕΙ Καλαμάτας, Τμήμα ΤΕΓΕΠ, Πτυχιακή Εργασία, Φαρμακευτικές ιδιότητες βασιδιομυκήτων και ασκομυκήτων, Δημητριάδου Ελένη,
212. Batra P, Sharma AK, Khajuria R. Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. Int J Med Mushrooms. 2013;15(2):127-43. doi: 10.1615/intjmedmushr.v15.i2.20. PMID: 23557365.
https://pubmed.ncbi.nlm.nih.gov/23557365
213. What Are Polyps and Adenomas? University of Rochester Medical Center
https://www.urmc.rochester.edu/conditions-and-treatments/polyps-and-adenomas
214. Adrian C. Bateman, Pathology of colorectal polyps and cancer, Surgery (Oxford), Volume 41, Issue 1, 2023, Pages 15-21, ISSN 0263-9319, https://doi.org/10.1016/j.mpsur.2022.10.011.
https://www.sciencedirect.com/science/article/abs/pii/S0263931922002101
215. Conteduca V, Sansonno D, Russi S, Dammacco F. Precancerous colorectal lesions (Review). Int J Oncol. 2013 Oct;43(4):973-84. doi: 10.3892/ijo.2013.2041. Epub 2013 Jul 29. PMID: 23900573.
https://pubmed.ncbi.nlm.nih.gov/23900573/
216. Munding J, Tannapfel A. Epidemiology of Colorectal Adenomas and Histopathological Assessment of Endoscopic Specimens in the Colorectum. Viszeralmedizin. 2014 Feb;30(1):10-6. doi: 10.1159/000357744. PMID: 26288577; PMCID: PMC4513795.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4513795/
217. Llovet, J.M., Kelley, R.K., Villanueva, A. et al. Hepatocellular carcinoma. Nat Rev Dis Primers 7, 6 (2021). https://doi.org/10.1038/s41572-020-00240-3
https://www.nature.com/articles/s41572-020-00240-3
218. Asafo-Agyei KO, Samant H. Hepatocellular Carcinoma. [Updated 2023 Jun 12]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK559177/
219. Huitzil-Melendez FD, Capanu M, O'Reilly EM, Duffy A, Gansukh B, Saltz LL, Abou-Alfa GK. Advanced hepatocellular carcinoma: which staging systems best predict prognosis? J Clin Oncol. 2010 Jun 10;28(17):2889-95. doi: 10.1200/JCO.2009.25.9895. Epub 2010 May 10. PMID: 20458042; PMCID: PMC3651603.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3651603/
220. Alves, Rogério & Alves, Daniele & Guz, Betty & Matos, Carla & Viana, Monica & Harriz, Michelle & Terrabuio, Deborah & Kondo, Mario & Gampel, Otávio & Polletti, Paula. (2011). Advanced hepatocellular carcinoma. Review of targeted molecular drugs. Annals of hepatology. 10. 21-7. 10.1016/S1665-2681(19)31582-0.
https://www.elsevier.es/en-revista-annals-hepatology-16-articulo-advanced-hepatocellular-carcinoma-review-targeted-S1665268119315820
221. Kim DW, Talati C, Kim R. Hepatocellular carcinoma (HCC): beyond sorafenib—chemotherapy. J Gastrointest Oncol 2017;8(2):256-265. doi: 10.21037/jgo.2016.09.07
https://jgo.amegroups.org/article/view/9549/html
222. Deng GL, Zeng S, Shen H. Chemotherapy and target therapy for hepatocellular carcinoma: New advances and challenges. World J Hepatol. 2015 Apr 18;7(5):787-98. doi: 10.4254/wjh.v7.i5.787. PMID: 25914779; PMCID: PMC4404384.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4404384/
223. W. Yeo, F.K.F. Mo, J. Koh, A.T.C. Chan, T. Leung, P. Hui, L. Chan, A. Tang, J.J. Lee, T.S.K. Mok, P.B.S. Lai, P.J. Johnson, B. Zee, Quality of life is predictive of survival in patients with unresectable hepatocellular carcinoma, Annals of Oncology, Volume 17, Issue 7, 2006, Pages 1083-1089, ISSN 0923-7534, https://doi.org/10.1093/annonc/mdl065.
https://www.sciencedirect.com/science/article/pii/S0923753419453751
224. Kennedy, A.S., Sangro, B. Nonsurgical Treatment for Localized Hepatocellular Carcinoma. Curr Oncol Rep 16, 373 (2014). https://doi.org/10.1007/s11912-013-0373-x
https://link.springer.com/article/10.1007/s11912-013-0373-x
225. Thomas W. T. Leung, Yehuda Z. Patt, Wan-yee Lau, Stephen K. W. Ho, Simon C. H. Yu, Anthony T. C. Chan, Tony S. K. Mok, Winnie Yeo, Choong-tsek Liew, Nancy W. Y. Leung, Amanda M. Y. Tang, Philip J. Johnson; Complete Pathological Remission Is Possible with Systemic Combination Chemotherapy for Inoperable Hepatocellular Carcinoma. Clin Cancer Res 1 July 1999; 5 (7): 1676–1681.
https://aacrjournals.org/clincancerres/article/5/7/1676/287579/Complete-Pathological-Remission-Is-Possible-with
226. Agirrezabal, I., Pollock, R.F., Carion, P.L. et al. Association of adverse events and quality of life in patients with unresectable hepatocellular carcinoma. Qual Life Res 33, 3377–3386 (2024). https://doi.org/10.1007/s11136-024-03779-w
https://link.springer.com/article/10.1007/s11136-024-03779-w
227. Gandhi S, Khubchandani S, Iyer R. Quality of life and hepatocellular carcinoma. J Gastrointest Oncol 2014;5(4):296-317. doi: 10.3978/j.issn.2078-6891.2014.046
https://jgo.amegroups.org/article/view/2783/html
228. Pathomjaruwat T, Matchim Y, Armer JM. Symptoms and symptom clusters in patients with hepatocellular carcinoma and commonly used instruments: An integrated review. Int J Nurs Sci. 2023 Sep 21;11(1):66-75. doi: 10.1016/j.ijnss.2023.09.009. PMID: 38352278; PMCID: PMC10859590.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10859590/
229. Christian-Miller N, Frenette C. Hepatocellular cancer pain: impact and management challenges. J Hepatocell Carcinoma. 2018 Jul 19;5:75-80. doi: 10.2147/JHC.S145450. PMID: 30050880; PMCID: PMC6055904.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6055904/
230. Sun VC, Sarna L. Symptom management in hepatocellular carcinoma. Clin J Oncol Nurs. 2008 Oct;12(5):759-66. doi: 10.1188/08.CJON.759-766. PMID: 18842532; PMCID: PMC2881685.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2881685/
231. Coriolus versicolor (Yunzhi) Use as Therapy in Advanced Hepatocellular Carcinoma Patients with Poor Liver Function or Who Are Unfit for Standard Therapy Wen Yee Chay, Chee Kian Tham, Han Chong Toh, Hwee Yong Lim, Chee Kiat Tan, Cindy Lim, Who-Whong Wang, and Su-Pin Choo The Journal of Alternative and Complementary Medicine 2017 23:8, 648-652
https://www.liebertpub.com/doi/10.1089/acm.2016.0136
232. Mahdy H, Vadakekut ES, Crotzer D. Endometrial Cancer. [Updated 2024 Apr 20]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK525981/
233. Liu L, Habeshian TS, Zhang J, Peeri NC, Du M, De Vivo I, Setiawan VW. Differential trends in rising endometrial cancer incidence by age, race, and ethnicity. JNCI Cancer Spectr. 2023 Jan 3;7(1):pkad001. doi: 10.1093/jncics/pkad001. PMID: 36625534; PMCID: PMC9904185.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9904185/
234. Spandidos Publications style Hahne JC, Meyer SR, Dietl J and Honig A: The effect of Cordyceps extract and a mixture of Ganoderma lucidum/Agaricus Blazi Murill extract on human endometrial cancer cell lines in vitro. Int J Oncol 45: 373-382, 2014.
https://www.spandidos-publications.com/10.3892/ijo.2014.2414
235. Tsai YT, Kuo PH, Kuo HP, Hsu CY, Lee YJ, Kuo CL, Liu JY, Lee SL, Kao MC. Ganoderma tsugae suppresses the proliferation of endometrial carcinoma cells via Akt signaling pathway. Environ Toxicol. 2021 Mar;36(3):320-327. doi: 10.1002/tox.23037. Epub 2020 Oct 12. PMID: 33044769.
https://pubmed.ncbi.nlm.nih.gov/33044769/
236. Shi M. The Efficacy of Ganoderma lucidum Extracts on Treating Endometrial Cancer: A Network Pharmacology Approach. Reprod Sci. 2024 Jul;31(7):1881-1894. doi: 10.1007/s43032-024-01500-3. Epub 2024 Mar 6. PMID: 38448739; PMCID: PMC11217070.
https://pubmed.ncbi.nlm.nih.gov/38448739/
237. Biedroń, Rafał & Tangen, Jon-Magnus & Maresz, Katarzyna & Hetland, Geir. (2012). Agaricus blazei Murill - immunomodulatory properties and health benefits. Funct Foods Health Dis. 2. 428-447. 10.31989/ffhd.v2i11.72.
https://ffhdj.com/index.php/ffhd/article/view/72/162
238. TianX, Lun Z, Ito J.Clinical observation on treatment of acute non lymphocytic leukemia with Agaricus blazei. Lanzhou Med Coll 1994;20:169–171.
https://www.springboard4health.com/notebook/health_agaricus_6.html
239. Meade E, Hehir S, Rowan N, Garvey M. Mycotherapy: Potential of Fungal Bioactives for the Treatment of Mental Health Disorders and Morbidities of Chronic Pain. J Fungi (Basel). 2022 Mar 11;8(3):290. doi: 10.3390/jof8030290. PMID: 35330292; PMCID: PMC8954642.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8954642/
240. Molla, G.; Bitew, M. The Future of Cancer Diagnosis and Treatment: Unlocking the Power of Biomarkers and Personalized Molecular-Targeted Therapies. J. Mol. Pathol. 2025, 6, 20. https://doi.org/10.3390/jmp6030020
https://www.mdpi.com/2673-5261/6/3/20
241. Wang X, Zhang H, Chen X. Drug resistance and combating drug resistance in cancer. Cancer Drug Resist. 2019;2(2):141-160. doi: 10.20517/cdr.2019.10. Epub 2019 Jun 19. PMID: 34322663; PMCID: PMC8315569.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8315569/
242. Dhanyamraju PK. Drug resistance mechanisms in cancers: Execution of pro-survival strategies. J Biomed Res. 2024 Feb 28;38(2):95-121. doi: 10.7555/JBR.37.20230248. PMID: 38413011; PMCID: PMC11001593.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11001593/
243. Yue Shi, Joseph Adu-Amankwaah, Qizhong Zhao, Xin Li, Qianxue Yu, Aisha Bushi, Jinxiang Yuan, Rubin Tan, Long non-coding RNAs in drug resistance across the top five cancers: Update on their roles and mechanisms, Heliyon, Volume 10, Issue 5, 2024, e27207, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2024.e27207.
https://www.sciencedirect.com/science/article/pii/S2405844024032389
244. Ingham, J., Ruan, JL. & Coelho, M.A. Breaking barriers: we need a multidisciplinary approach to tackle cancer drug resistance. BJC Rep 3, 11 (2025). https://doi.org/10.1038/s44276-025-00129-2
https://www.nature.com/articles/s44276-025-00129-2
245. To Combat Cancer Treatment Resistance, Researchers Try Leveraging Evolution August 22, 2024, by Carmen Phillips, National Cancer Institute
https://www.cancer.gov/news-events/cancer-currents-blog/2024/cancer-treatment-resistance-engineering-evolution
246. Roda, Elisa, et al. "From a medicinal mushroom blend a direct anticancer effect on triple-negative breast cancer: a preclinical study on lung metastases." Molecules 25.22 (2020): 5400.
Google Scholar
247. De Luca, Fabrizio, et al. "Fighting secondary triple-negative breast cancer in cerebellum: a powerful aid from a medicinal mushrooms blend." Biomedicine & Pharmacotherapy 159 (2023): 114262.
Google Scholar
248. Abdullah, E.; Abidin, N.Z.; Abdullah, N. Cytotoxic Proteins from King Tuber Oyster Medicinal Mushroom, Pleurotus Tuber-Regium (Agaricomycetes), Sclerotium against Human MDA-MB-231 Breast Cancer Cells. Int. J. Med. Mushrooms 2022, 24, 27–40
Google Scholar
249. Wong JH, Ng TB, Chan HHL, Liu Q, Man GCW, Zhang CZ, Guan S, Ng CCW, Fang EF, Wang H, Liu F, Ye X, Rolka K, Naude R, Zhao S, Sha O, Li C, Xia L. Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials. Appl Microbiol Biotechnol. 2020 Jun;104(11):4675-4703. doi: 10.1007/s00253-020-10476-4. Epub 2020 Apr 9. PMID: 32274562.
https://pubmed.ncbi.nlm.nih.gov/32274562/
250. Cai H, Li J, Gu B, Xiao Y, Chen R, Liu X, Xie X, Cao L. Extracts of Cordyceps sinensis inhibit breast cancer cell metastasis via down-regulation of metastasis-related cytokines expression. J Ethnopharmacol. 2018 Mar 25;214:106-112. doi: 10.1016/j.jep.2017.12.012. Epub 2017 Dec 15. PMID: 29253616.
https://pubmed.ncbi.nlm.nih.gov/29253616/
251. Zhong C, Li Y, Li W, Lian S, Li Y, Wu C, Zhang K, Zhou G, Wang W, Xu H, Huang M, Katanaev V, Jia L, Lu Y. Ganoderma lucidum extract promotes tumor cell pyroptosis and inhibits metastasis in breast cancer. Food Chem Toxicol. 2023 Apr;174:113654. doi: 10.1016/j.fct.2023.113654. Epub 2023 Feb 8. PMID: 36758785.
https://pubmed.ncbi.nlm.nih.gov/36758785/
252. Martínez-Montemayor, Michelle M., et al. "Ganoderma lucidum (Reishi) inhibits cancer cell growth and expression of key molecules in inflammatory breast cancer." Nutrition and cancer 63.7 (2011): 1085-1094.
Google Scholar
253. Zhang Y, Sun D, Meng Q, Guo W, Chen Q, Zhang Y. [Corrigendum] Grifola frondosa polysaccharides induce breast cancer cell apoptosis via the mitochondrial-dependent apoptotic pathway. Int J Mol Med. 2022 Nov;50(5):136. doi: 10.3892/ijmm.2022.5192. Epub 2022 Sep 21. Erratum for: Int J Mol Med. 2017 Oct;40(4):1089-1095. doi: 10.3892/ijmm.2017.3081. PMID: 36129150; PMCID: PMC9559173.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9559173/
254. Hseu, You-Cheng, et al. "Antrodia salmonea suppresses invasion and metastasis in triple-negative breast cancer cells by reversing EMT through the NF-κB and Wnt/β-catenin signaling pathway." Food and Chemical Toxicology 124 (2019): 219-230.
https://pubmed.ncbi.nlm.nih.gov/30529123/
255. De Luca, F.; Roda, E.; Rossi, P.; Bottone, M.G. Medicinal Mushrooms in Metastatic Breast Cancer: What Is Their Therapeutic Potential as Adjuvant in Clinical Settings? Curr. Issues Mol. Biol. 2024, 46, 7577-7591. https://doi.org/10.3390/cimb46070450
https://www.mdpi.com/1467-3045/46/7/450
256. Gariboldi MB, Marras E, Ferrario N, Vivona V, Prini P, Vignati F, Perletti G. Anti-Cancer Potential of Edible/Medicinal Mushrooms in Breast Cancer. Int J Mol Sci. 2023 Jun 14;24(12):10120. doi: 10.3390/ijms241210120. PMID: 37373268; PMCID: PMC10299416.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10299416/
257. Zhang Y, Wang X, Chen T. Efficacy of Huaier granule in patients with breast cancer. Clin Transl Oncol. 2019 May;21(5):588-595. doi: 10.1007/s12094-018-1959-4. Epub 2018 Oct 1. PMID: 30276759.
https://pubmed.ncbi.nlm.nih.gov/30276759/
258. Zhao H, Zhang Q, Zhao L, Huang X, Wang J, Kang X. Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial. Evid Based Complement Alternat Med. 2012;2012:809614. doi: 10.1155/2012/809614. Epub 2011 Dec 10. PMID: 22203880; PMCID: PMC3236089.
https://pubmed.ncbi.nlm.nih.gov/22203880/
259. Karnofsky Performance Status Scale, Jan 19, 2023, WebMD, Buck Christensen; Buck Christensen
https://emedicine.medscape.com/article/2172510-overview?form=fpf
260. Myelodysplastic syndrome (MDS), NHS of UK,
https://www.nhs.uk/conditions/myelodysplastic-syndrome-mds/
261. Bülbül, Hale MDa,*; Kaya, Özge Özer MDb; Karadağ, Fatma Keklik MDa; Olgun, Aybüke MDa; Demirci, Zühal PhDc; Ceylan, Cengiz MDa. Prognostic impact of next-generation sequencing on myelodysplastic syndrome: A single-center experience. Medicine 103(41):p e39909, October 11, 2024. | DOI: 10.1097/MD.0000000000039909
https://journals.lww.com/md-journal/fulltext/2024/10110/prognostic_impact_of_next_generation_sequencing_on.33.aspx
262. Dotson JL, Lebowicz Y. Myelodysplastic Syndrome. [Updated 2022 Jul 18]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK534126/
263. How I Treat Anemia Associated with Lower-Risk Myelodysplastic Syndromes JHOP - June 2021 Vol 11, No 3 - Symptom Management Overview, Myelodysplastic Syndromes Brenna Rowen, PharmD, BCOP
https://jhoponline.com/articles/how-i-treat-anemia-associated-with-lower-risk-myelodysplastic-syndromes
264. Matsunawa, M., Inoue, Y., Yagihashi, K., Aida, Y., Uchida, A., Uemura, Y., Saiki, Y., Takimoto, M., Sano, F., Miura, I. and Arai, A. (2021), The clinicopathological analysis of organising pneumonia in myelodysplastic syndrome: high frequency in der(1;7)(q10; p10). Br. J. Haematol., 194: 214-217. https://doi.org/10.1111/bjh.17473
https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.17473
265. Toma A, Fenaux P, Dreyfus F, Cordonnier C. Infections in myelodysplastic syndromes. Haematologica. 2012 Oct;97(10):1459-70. doi: 10.3324/haematol.2012.063420. Epub 2012 Jun 24. PMID: 22733024; PMCID: PMC3487546.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3487546/
266. Barnea, I.; Luria, L.; Girsault, A.; Dabah, O.; Dudaie, M.; Mirsky, S.K.; Merkel, D.; Shaked, N.T. Analyzing Blood Cells of High-Risk Myelodysplastic Syndrome Patients Using Interferometric Phase Microscopy and Fluorescent Flow Cytometry. Bioengineering 2024, 11, 256. https://doi.org/10.3390/bioengineering11030256
https://www.mdpi.com/2306-5354/11/3/256
267. Kasprzak A, Andresen J, Nachtkamp K, Kündgen A, Schulz F, Strupp C, Kobbe G, MacKenzie C, Timm J, Dietrich S, Gattermann N, Germing U. Infectious Complications in Patients with Myelodysplastic Syndromes: A Report from the Düsseldorf MDS Registry. Cancers (Basel). 2024 Feb 16;16(4):808. doi: 10.3390/cancers16040808. PMID: 38398198; PMCID: PMC10887010.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10887010/
268. Radsak M, Platzbecker U, Schmidt CS, Hofmann W-K, Nolte F. Infectious complications in patients with myelodysplastic syndromes: A review of the literature with emphasis on patients treated with. Eur J Haematol. 2017; 99: 112–118. https://doi.org/10.1111/ejh.12883
https://onlinelibrary.wiley.com/doi/10.1111/ejh.12883
269. Gonçalves AC, Alves R, Baldeiras I, Jorge J, Marques B, Paiva A, Oliveiros B, Cortesão E, Nascimento Costa JM and Sarmento-Ribeiro AB (2021) Oxidative Stress Parameters Can Predict the Response to Erythropoiesis-Stimulating Agents in Myelodysplastic Syndrome Patients. Front. Cell Dev. Biol. 9:701328. doi: 10.3389/fcell.2021.701328
https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.701328/full
270. Jing Q, Zhou C, Zhang J, Zhang P, Wu Y, Zhou J, Tong X, Li Y, Du J, Wang Y. Role of reactive oxygen species in myelodysplastic syndromes. Cell Mol Biol Lett. 2024 Apr 14;29(1):53. doi: 10.1186/s11658-024-00570-0. PMID: 38616283; PMCID: PMC11017617.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11017617/
271. Yuo Akira, Kitagawa Seiichi, Okabe Tetsuro, Urabe Akio, Komatsu Yoshinori, Itoh Seiga, Takaku Fumimaro, Recombinant Human Granulocyte Colony-Stimulating Factor Repairs the Abnormalities of Neutrophils in Patients With Myelodysplastic Syndromes and Chronic Myelogenous Leukemia, Blood, Volume 70, Issue 2, 1987, Pages 404-411, ISSN 0006-4971, https://doi.org/10.1182/blood.V70.2.404.404.
https://www.sciencedirect.com/science/article/pii/S0006497120784302
272. Fuhler, Gwenny Manel. “Neutrophil functions in patients with myelodysplasia: implications of impaired.” (2005).
https://pure.rug.nl/ws/portalfiles/portal/2891599/c4.pdf
273. The role of hematopoietic growth factors in the treatment of patients with Myelodysplastic Syndromes Haema 2012; 3(2): 143-150 by Maria Psillaki, Katerina Pirovolaki, Helen A. Papadaki Hematology Clinic, University Hospital, Heraklion, Crete
https://haema-journal.gr/?p=547
274. Steensma DP. Hematopoietic growth factors in myelodysplastic syndromes. Semin Oncol. 2011 Oct;38(5):635-47. doi: 10.1053/j.seminoncol.2011.04.014. PMID: 21943670.
https://pubmed.ncbi.nlm.nih.gov/21943670/
275. Wesa KM, Cunningham-Rundles S, Klimek VM, Vertosick E, Coleton MI, Yeung KS, Lin H, Nimer S, Cassileth BR. Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother. 2015 Feb;64(2):237-47. doi: 10.1007/s00262-014-1628-6. Epub 2014 Oct 29. PMID: 25351719; PMCID: PMC4317517.
https://pubmed.ncbi.nlm.nih.gov/25351719/
276. Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Prz Gastroenterol. 2019;14(2):89-103. doi: 10.5114/pg.2018.81072. Epub 2019 Jan 6. PMID: 31616522; PMCID: PMC6791134.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6791134/
277. Leon Klimeck, Thomas Heisser, Michael Hoffmeister, Hermann Brenner, Colorectal cancer: A health and economic problem, Best Practice & Research Clinical Gastroenterology, Volume 66, 2023, 101839, ISSN 1521-6918, https://doi.org/10.1016/j.bpg.2023.101839.
https://www.sciencedirect.com/science/article/abs/pii/S1521691823000197
278. Siegel RL, Wagle NS, Cercek A, Smith RA, Jemal A. Colorectal cancer statistics, 2023. CA Cancer J Clin. 2023 May-Jun;73(3):233-254. doi: 10.3322/caac.21772. Epub 2023 Mar 1. PMID: 36856579.
https://pubmed.ncbi.nlm.nih.gov/36856579/
279. Ilyas MIM. Epidemiology of Stage IV Colorectal Cancer: Trends in the Incidence, Prevalence, Age Distribution, and Impact on Life Span. Clin Colon Rectal Surg. 2023 Mar 15;37(2):57-61. doi: 10.1055/s-0043-1761447. PMID: 38322602; PMCID: PMC10843881.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10843881/
280. Fritz, H.; Kennedy, D.A.; Ishii, M.; Fergusson, D.; Fernandes, R.; Cooley, K.; Seely, D. Polysaccharide K and Coriolus versicolor Extracts for Lung Cancer. Integr. Cancer Ther. 2015, 14, 201–211.
https://pubmed.ncbi.nlm.nih.gov/25784670/
281. Shahid A, Chen M, Yeung S, Parsa C, Orlando R, Huang Y. The medicinal mushroom Ganoderma lucidum prevents lung tumorigenesis induced by tobacco smoke carcinogens. Front Pharmacol. 2023 Sep 6;14:1244150. doi: 10.3389/fphar.2023.1244150. PMID: 37745066; PMCID: PMC10516555.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10516555/
282. Sangtitanu, T.; Sangtanoo, P.; Srimongkol, P.; Saisavoey, T.; Reamtong, O.; Karnchanatat, A. Peptides obtained from edible mushrooms: Hericium erinaceus offers the ability to scavenge free radicals and induce apoptosis in lung cancer cells in humans. Food Funct. 2020, 11, 4927–4939.
https://pubs.rsc.org/en/content/articlelanding/2020/fo/d0fo00227e/unauth
283. Mihi Yang, Hee-Kyung Jang, Huiwon Kang. How do shiitake and reishi mushrooms work on lung cancer?: A high throughput screening of 3D cell culture. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4553.
https://aacrjournals.org/cancerres/article/83/7_Supplement/4553/724521/Abstract-4553-How-do-shiitake-and-reishi-mushrooms
284. Park, S.E.; Yoo, H.S.; Jin, C.-Y.; Hong, S.H.; Lee, Y.-W.; Kim, B.W.; Lee, S.H.; Kim, W.-J.; Cho, C.K.; Choi, Y.H. Induction of apoptosis and inhibition of telomerase activity in human lung carcinoma cells by the water extract of Cordyceps militaris. Food Chem. Toxicol. 2009, 47, 1667–1675.
https://www.sciencedirect.com/science/article/abs/pii/S0278691509001744
285. Hsu, W.-H.; Qiu, W.-L.; Tsao, S.-M.; Tseng, A.-J.; Lu, M.-K.; Hua, W.-J.; Cheng, H.-C.; Hsu, H.-Y.; Lin, T.-Y. Effects of WSG, a polysaccharide from Ganoderma lucidum, on suppressing cell growth and mobility of lung cancer. Int. J. Biol. Macromol. 2020, 165, 1604–1613.
https://pubmed.ncbi.nlm.nih.gov/33011264/
286. Spandidos Publications style Loganathan J, Jiang J, Smith A, Jedinak A, Thyagarajan-Sahu A, Sandusky GE, Nakshatri H and Sliva D: The mushroom Ganoderma lucidum suppresses breast-to-lung cancer metastasis through the inhibition of pro-invasive genes. Int J Oncol 44: 2009-2015, 2014.
https://www.spandidos-publications.com/10.3892/ijo.2014.2375
287. Lai, Wei & Zainal, Zamri & Daud, Fauzi. (2014). Preliminary study on the potential of polysaccharide from indigenous Tiger's Milk mushroom (Lignosus rhinocerus) as anti-lung cancer agent. 1614. 517-519. 10.1063/1.4895252.
https://www.researchgate.net/publication/299862394_Preliminary_study_on_the_potential_of_polysaccharide_from_indigenous_Tiger%27s_Milk_mushroom_Lignosus_rhinocerus_as_anti-lung_cancer_agent
https://www.spandidos-publications.com/10.3892/ijo.2014.2375
288. Secme M, Kaygusuz O, Eroglu C, Dodurga Y, Colak OF, Atmaca P. Potential Anticancer Activity of the Parasol Mushroom, Macrolepiota procera (Agaricomycetes), against the A549 Human Lung Cancer Cell Line. Int J Med Mushrooms. 2018;20(11):1075-1086. doi: 10.1615/IntJMedMushrooms.2018028589. PMID: 30806231.
https://www.dl.begellhouse.com/journals/708ae68d64b17c52,6e2de2a705b6ffd3,11ce65196897bbc7.html
289. Huo, Xiaowei & Liu, Chenqi & Bai, Xuelian & Li, Wenjia & Li, Jing & Hu, Xuefeng & Cao, Li. (2017). Aqueous extract of Cordyceps sinensis potentiates the antitumor effect of DDP and attenuates therapy-associated toxicity in non-small cell lung cancer via IκBα/NFκB and AKT/MMP2/MMP9 pathways. RSC Adv.. 7. 37743-37754. 10.1039/C7RA04716A.
https://www.researchgate.net/publication/318820879_Aqueous_extract_of_Cordyceps_sinensis_potentiates_the_antitumor_effect_of_DDP_and_attenuates_therapy-associated_toxicity_in_non-small_cell_lung_cancer_via_IkBaNFkB_and_AKTMMP2MMP9_pathways
290. Bizarro A, Ferreira IC, Soković M, van Griensven LJ, Sousa D, Vasconcelos MH, Lima RT. Cordyceps militaris (L.) Link Fruiting Body Reduces the Growth of a Non-Small Cell Lung Cancer Cell Line by Increasing Cellular Levels of p53 and p21. Molecules. 2015 Jul 31;20(8):13927-40. doi: 10.3390/molecules200813927. PMID: 26263965; PMCID: PMC6332316.
https://pubmed.ncbi.nlm.nih.gov/26263965/
291. Khunoana ET, Nkadimeng SM. Current Advances in the Use of Mushrooms as Therapeutics for Lung Cancer: A Review. Molecules. 2025 Mar 14;30(6):1322. doi: 10.3390/molecules30061322. PMID: 40142097; PMCID: PMC11944945.
https://pubmed.ncbi.nlm.nih.gov/40142097/
292. What Is Stomach Cancer? January 22, 2021 American Cancer Society
https://www.cancer.org/cancer/types/stomach-cancer/about/what-is-stomach-cancer.html
293. Menon G, El-Nakeep S, Babiker HM. Gastric Cancer. [Updated 2024 Oct 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK459142/
294. Zaręba KP, Zińczuk J, Dawidziuk T, Pryczynicz A, Guzińska-Ustymowicz K, Kędra B. Stomach cancer in young people - a diagnostic and therapeutic problem. Prz Gastroenterol. 2019;14(4):283-285. doi: 10.5114/pg.2019.90254. Epub 2019 Dec 20. PMID: 31988675; PMCID: PMC6983757.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6983757/
295. Zhang H, Yang W, Tan X, He W, Zhao L, Liu H, Li G. Long-term relative survival of patients with gastric cancer from a large-scale cohort: a period-analysis. BMC Cancer. 2024 Nov 18;24(1):1420. doi: 10.1186/s12885-024-13141-5. PMID: 39558281; PMCID: PMC11571998.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11571998/
296. Gargano ML, Venturella G, Bosco F, Fabrini MG, Gao W, Pecoraro L. The Role of Medicinal Mushrooms in Brain Cancer Therapies: Review. Int J Med Mushrooms. 2021;23(5):13-20. doi: 10.1615/IntJMedMushrooms.2021038277. PMID: 34347991.
https://pubmed.ncbi.nlm.nih.gov/34347991/
297. Zhang M, Zhang Y, Zhang L, Tian Q. Mushroom polysaccharide lentinan for treating different types of cancers: A review of 12 years clinical studies in China. Prog Mol Biol Transl Sci. 2019;163:297-328. doi: 10.1016/bs.pmbts.2019.02.013. Epub 2019 Apr 4. PMID: 31030752.
https://pubmed.ncbi.nlm.nih.gov/31030752/
298. Zeng P, Chen Y, Zhang L, Xing M. Ganoderma lucidum polysaccharide used for treating physical frailty in China. Prog Mol Biol Transl Sci. 2019;163:179-219. doi: 10.1016/bs.pmbts.2019.02.009. Epub 2019 Mar 26. PMID: 31030748.
https://pubmed.ncbi.nlm.nih.gov/31030748/
299. Jakopovic B, Oršolić N, Jakopovich I. Proteomic Research on the Antitumor Properties of Medicinal Mushrooms. Molecules. 2021 Nov 5;26(21):6708. doi: 10.3390/molecules26216708. PMID: 34771120; PMCID: PMC8588050.
https://pubmed.ncbi.nlm.nih.gov/34771120/
300. Tangen JM, Tierens A, Caers J, Binsfeld M, Olstad OK, Trøseid AM, Wang J, Tjønnfjord GE, Hetland G. Immunomodulatory effects of the Agaricus blazei Murrill-based mushroom extract AndoSan in patients with multiple myeloma undergoing high dose chemotherapy and autologous stem cell transplantation: a randomized, double blinded clinical study. Biomed Res Int. 2015;2015:718539. doi: 10.1155/2015/718539. Epub 2015 Jan 18. PMID: 25664323; PMCID: PMC4312620.
https://pubmed.ncbi.nlm.nih.gov/25664323/
Οξεία μη-λεμφοκυτταρική λευχαιμία
1. Biedroń, Rafał & Tangen, Jon-Magnus & Maresz, Katarzyna & Hetland, Geir. (2012). Agaricus blazei Murill – immunomodulatory properties and health benefits. Funct Foods Health Dis. 2. 428-447. 10.31989/ffhd.v2i11.72.
https://ffhdj.com/index.php/ffhd/article/view/72/162
2. Meade E, Hehir S, Rowan N, Garvey M. Mycotherapy: Potential of Fungal Bioactives for the Treatment of Mental Health Disorders and Morbidities of Chronic Pain. J Fungi (Basel). 2022 Mar 11;8(3):290. doi: 10.3390/jof8030290. PMID: 35330292; PMCID: PMC8954642.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8954642/
3. PDQ® Integrative, Alternative, and Complementary Therapies Editorial Board. PDQ Medicinal Mushrooms. Bethesda, MD: National Cancer Institute. Updated July 11, 2024. Available at: https://www.cancer.gov/about-cancer/treatment/cam/patient/mushrooms-pdq. Accessed 27/12/2025. [PMID: 28267306]
4. Molla, G.; Bitew, M. The Future of Cancer Diagnosis and Treatment: Unlocking the Power of Biomarkers and Personalized Molecular-Targeted Therapies. J. Mol. Pathol. 2025, 6, 20. https://doi.org/10.3390/jmp6030020
https://www.mdpi.com/2673-5261/6/3/20
5. Wang X, Zhang H, Chen X. Drug resistance and combating drug resistance in cancer. Cancer Drug Resist. 2019;2(2):141-160. doi: 10.20517/cdr.2019.10. Epub 2019 Jun 19. PMID: 34322663; PMCID: PMC8315569.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8315569/
6. Dhanyamraju PK. Drug resistance mechanisms in cancers: Execution of pro-survival strategies. J Biomed Res. 2024 Feb 28;38(2):95-121. doi: 10.7555/JBR.37.20230248. PMID: 38413011; PMCID: PMC11001593.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11001593/
7. Yue Shi, Joseph Adu-Amankwaah, Qizhong Zhao, Xin Li, Qianxue Yu, Aisha Bushi, Jinxiang Yuan, Rubin Tan, Long non-coding RNAs in drug resistance across the top five cancers: Update on their roles and mechanisms, Heliyon, Volume 10, Issue 5, 2024, e27207, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2024.e27207.
https://www.sciencedirect.com/science/article/pii/S2405844024032389
8. Ingham, J., Ruan, JL. & Coelho, M.A. Breaking barriers: we need a multidisciplinary approach to tackle cancer drug resistance. BJC Rep 3, 11 (2025). https://doi.org/10.1038/s44276-025-00129-2
https://www.nature.com/articles/s44276-025-00129-2
9. To Combat Cancer Treatment Resistance, Researchers Try Leveraging Evolution August 22, 2024, by Carmen Phillips, National Cancer Institute
https://www.cancer.gov/news-events/cancer-currents-blog/2024/cancer-treatment-resistance-engineering-evolution
10. TianX, Lun Z, Ito J.Clinical observation on treatment of acute non lymphocytic leukemia with Agaricus blazei. Lanzhou Med Coll 1994;20:169–171.
https://www.springboard4health.com/notebook/health_agaricus_6.html
Άνοια
1. Survey Finds Brain Health is a Top Priority for Americans a woman smiling at the camera By Paula Croxson, Ph.D. Dana Foundation
https://dana.org/article/survey-finds-brain-health-is-a-top-priority-for-americans/
2. Avan A, Hachinski V, the Brain Health Learn, Act Group. Brain health: Key to health, productivity, and well-being. Alzheimer's Dement. 2022; 18: 1396–1407. https://doi.org/10.1002/alz.12478
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.12478
3. Alzheimer's Disease Facts and Figures, Alzheimer's Association
https://www.alz.org/alzheimers-dementia/facts-figures
4. World Health Organisation’s Global Health Estimates reveal dementia as a top three cause of death in Europe, Alzheimer Europe, 09/12/2020
https://www.alzheimer-europe.org/news/world-health-organisations-global-health-estimates-reveal-dementia-top-three-cause-death?language_content_entity=en
5. ReFaey K, Tripathi S, Grewal SS, Bhargav AG, Quinones DJ, Chaichana KL, Antwi SO, Cooper LT, Meyer FB, Dronca RS, Diasio RB, Quinones-Hinojosa A. Cancer Mortality Rates Increasing vs Cardiovascular Disease Mortality Decreasing in the World: Future Implications. Mayo Clin Proc Innov Qual Outcomes. 2021 Jun 8;5(3):645-653. doi: 10.1016/j.mayocpiqo.2021.05.005. PMID: 34195556; PMCID: PMC8240359.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8240359/
6. Lewis JE, Poles J, Shaw DP, et al. The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. Journal of Clinical and Translational Research. 2021 Aug;7(4):575-620. PMID: 34541370; PMCID: PMC8445631.
https://europepmc.org/article/MED/34541370
7. Yiannopoulou KG, Papageorgiou SG. Current and Future Treatments in Alzheimer Disease: An Update. J Cent Nerv Syst Dis. 2020 Feb 29;12:1179573520907397. doi: 10.1177/1179573520907397. PMID: 32165850; PMCID: PMC7050025.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7050025/
8. Neuroscience, Brain Health and Nutrients, Clinical Education
https://www.clinicaleducation.org/brain-health/neuroscience-brain-health-and-nutrients/
9. Stamets P, Zwickey H. Medicinal Mushrooms: Ancient Remedies Meet Modern Science. Integr Med (Encinitas). 2014 Feb;13(1):46-7. PMID: 26770081; PMCID: PMC4684114.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4684114/
10. Zhang S, Zhang S, Tomata Y, et al. Mushroom Consumption and Incident Dementia in Elderly Japanese: The Ohsaki Cohort 2006 Study. Journal of the American Geriatrics Society. 2017 Jul;65(7):1462-1469. DOI: 10.1111/jgs.14812. PMID: 28295137.
https://europepmc.org/article/MED/28295137
11. Yin Z, Chen J, Zhang J, et al. Dietary Patterns Associated with Cognitive Function among the Older People in Underdeveloped Regions: Finding from the NCDFaC Study. Nutrients. 2018 Apr;10(4):E464. DOI: 10.3390/nu10040464. PMID: 29642510; PMCID: PMC5946249.
https://europepmc.org/article/MED/29642510
12. Shang X, Hodge AM, Hill E, Zhu Z, He M. Associations of Dietary Pattern and Sleep Duration with Cognitive Decline in Community-Dwelling Older Adults: A Seven-Year Follow-Up Cohort Study. J Alzheimers Dis. 2021;82(4):1559-1571. doi: 10.3233/JAD-201329. PMID: 34180411.
https://pubmed.ncbi.nlm.nih.gov/34180411/
13. Medicinal Mushrooms (PDQ®)–Patient Version, July 11, 2024, National Cancer Institute at the National Institutes of Health
https://www.cancer.gov/about-cancer/treatment/cam/patient/mushrooms-pdq
14. Sabaratnam V, Kah-Hui W, Naidu M, Rosie David P. Neuronal health - can culinary and medicinal mushrooms help? J Tradit Complement Med. 2013 Jan;3(1):62-8. doi: 10.4103/2225-4110.106549. PMID: 24716157; PMCID: PMC3924982.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3924982/
15. Stephen McMahon, Beth Murinson, CHAPTER 25 - Therapeutic Potential of Neurotrophic Factors, Editor(s): Stephen Waxman, From Neuroscience To Neurology, Academic Press, 2005, Pages 419-431, ISBN 9780127389035, https://doi.org/10.1016/B978-012738903-5/50026-6.
https://www.sciencedirect.com/science/article/abs/pii/B9780127389035500266
16. Ganesan, Anusiya & Udayakumar, Gowthama Prabu & Yamini, N & Sivarajasekar, N. & K, Rambabu & Govindan, Bharath & Banat, Fawzi. (2021). A review of the therapeutic and biological effects of edible and wild mushrooms. Bioengineered. 12. 10.1080/21655979.2021.2001183.
https://www.researchgate.net/publication/355953195_A_review_of_the_therapeutic_and_biological_effects_of_edible_and_wild_mushrooms
17. Mushrooms magnify memory by boosting nerve growth, 10 February 2023, The University of Queensland
ttps://www.uq.edu.au/news/article/2023/02/mushrooms-magnify-memory-boosting-nerve-growth-0
18. Eik LF, Naidu M, David P, Wong KH, Tan YS, Sabaratnam V. Lignosus rhinocerus (Cooke) Ryvarden: A Medicinal Mushroom That Stimulates Neurite Outgrowth in PC-12 Cells. Evid Based Complement Alternat Med. 2012;2012:320308. doi: 10.1155/2012/320308. Epub 2011 Dec 6. PMID: 22203867; PMCID: PMC3235797.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3235797/
19. Khodosevich, K., Monyer, H. Signaling involved in neurite outgrowth of postnatally born subventricular zone neurons in vitro. BMC Neurosci 11, 18 (2010). https://doi.org/10.1186/1471-2202-11-18
https://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-11-18
20. Miller KE and Suter DM (2018) An Integrated Cytoskeletal Model of Neurite Outgrowth. Front. Cell. Neurosci. 12:447. doi: 10.3389/fncel.2018.00447
https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2018.00447/full
21. Szućko-Kociuba I, Trzeciak-Ryczek A, Kupnicka P, Chlubek D. Neurotrophic and Neuroprotective Effects of Hericium erinaceus. Int J Mol Sci. 2023 Nov 3;24(21):15960. doi: 10.3390/ijms242115960. PMID: 37958943; PMCID: PMC10650066.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10650066/
22. Aloe L, Rocco ML, Balzamino BO, Micera A. Nerve Growth Factor: A Focus on Neuroscience and Therapy. Curr Neuropharmacol. 2015;13(3):294-303. doi: 10.2174/1570159x13666150403231920. PMID: 26411962; PMCID: PMC4812798.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4812798/
23. Capossela, L.; Gatto, A.; Ferretti, S.; Di Sarno, L.; Graglia, B.; Massese, M.; Soligo, M.; Chiaretti, A. Multifaceted Roles of Nerve Growth Factor: A Comprehensive Review with a Special Insight into Pediatric Perspectives. Biology 2024, 13, 546. https://doi.org/10.3390/biology13070546
https://www.mdpi.com/2079-7737/13/7/546
24. Zhang, Y., Chen, H., Li, R. et al. Amyloid β-based therapy for Alzheimer’s disease: challenges, successes and future. Sig Transduct Target Ther 8, 248 (2023). https://doi.org/10.1038/s41392-023-01484-7
https://www.nature.com/articles/s41392-023-01484-7
25. Murphy MP, LeVine H 3rd. Alzheimer's disease and the amyloid-beta peptide. J Alzheimers Dis. 2010;19(1):311-23. doi: 10.3233/JAD-2010-1221. PMID: 20061647; PMCID: PMC2813509.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2813509/
26. Ancient medicine could hold the key to dementia treatment, The University of Queensland
https://stories.uq.edu.au/research/2023/ancient-medicine-could-hold-key-to-dementia-treatment/index.html
27. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytotherapy Research : PTR. 2009 Mar;23(3):367-372. DOI: 10.1002/ptr.2634. PMID: 18844328.
https://europepmc.org/article/MED/18844328
28. Saitsu Y, Nishide A, Kikushima K, Shimizu K, Ohnuki K. Improvement of cognitive functions by oral intake of Hericium erinaceus. Biomedical Research (Tokyo, Japan). 2019 ;40(4):125-131. DOI: 10.2220/biomedres.40.125. PMID: 31413233.
https://europepmc.org/article/MED/31413233
29. Fear of dementia overtakes cancer for older Australians, as new study looks at lifestyle and diet options By medical reporter Sophie Scott and the Specialist Reporting Team's Brooke Wylie, Mon 25 Nov 2019, ABC News
https://www.abc.net.au/news/2019-11-26/dementia-lifestyle-exercise-diet-options-give-hint-at-prevention/11722796
30. Dementia tsunami: Alzheimer's and other dementias to triple by 2050 3 September 2015, University of Sydney
https://www.sydney.edu.au/news-opinion/news/2015/09/03/the-dementia-tsunami--alzheimer-s-disease-and-other-dementias-ex.html
31. Riley RJ, Burgener S, Buckwalter KC. Anxiety and stigma in dementia: a threat to aging in place. Nurs Clin North Am. 2014 Jun;49(2):213-31. doi: 10.1016/j.cnur.2014.02.008. PMID: 24846469; PMCID: PMC4032087.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4032087/
32. Fear of Alzheimer's disease in the French population: impact of age and proximity to the disease Cantegreil-Kallen, Inge et al. International Psychogeriatrics, Volume 24, Issue 1, 108 - 116
https://www.intpsychogeriatrics.org/article/S1041-6102(24)02120-3/fulltext
33. (2014), 2014 Alzheimer's disease facts and figures. Alzheimer's & Dementia, 10: e47-e92. https://doi.org/10.1016/j.jalz.2014.02.001
https://alz-journals.onlinelibrary.wiley.com/doi/10.1016/j.jalz.2014.02.001
34. Watson R, Sanson-Fisher R, Bryant J, Mansfield E. Dementia is the second most feared condition among Australian health service consumers: results of a cross-sectional survey. BMC Public Health. 2023 May 12;23(1):876. doi: 10.1186/s12889-023-15772-y. PMID: 37173717; PMCID: PMC10176813.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10176813/
35. Fear of diseases among people over 50 years of age: A survey, Martin Bystad, Ole Grønli, Camilla Lilleeggen & Per M. Aslaksen Last updated: 16.11.19 Published: 11.12.16, Psykologisk.no
https://psykologisk.no/sp/2016/12/e19/
36. Dementia ‘more feared than cancer’ by older patients 04 August, 2014 By The Press Association, Nursing Times
https://www.nursingtimes.net/older-peoples-nursing/dementia-more-feared-than-cancer-by-older-patients-04-08-2014/
37. Over half of people fear dementia diagnosis, 62 per cent think it means 'life is over' Friday 13 May 2016, Alzheimer's Society
https://www.alzheimers.org.uk/news/2024-11-22/over-half-people-fear-dementia-diagnosis-62-cent-think-it-means-life-over
38. 22 August, 2024, RightCare dementia scenario, NHS England
https://www.england.nhs.uk/long-read/rightcare-dementia-scenario/
39. The later stage of dementia, Alzheimer's Society,
https://www.alzheimers.org.uk/about-dementia/symptoms-and-diagnosis/how-dementia-progresses/later-stages-dementia
40. La Monica MB, Raub B, Ziegenfuss EJ, Hartshorn S, Grdic J, Gustat A, Sandrock J, Ziegenfuss TN. Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion's Mane Extracts on Cognitive Performance. Nutrients. 2023 Dec 6;15(24):5018. doi: 10.3390/nu15245018. PMID: 38140277; PMCID: PMC10745489.
https://pubmed.ncbi.nlm.nih.gov/38140277/
41. Li IC, Chang HH, Lin CH, Chen WP, Lu TH, Lee LY, Chen YW, Chen YP, Chen CC, Lin DP. Prevention of Early Alzheimer's Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study. Front Aging Neurosci. 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PMID: 32581767; PMCID: PMC7283924.
https://pubmed.ncbi.nlm.nih.gov/32581767/
42. Teng EL, Hasegawa K, Homma A, Imai Y, Larson E, Graves A, Sugimoto K, Yamaguchi T, Sasaki H, Chiu D, et al. The Cognitive Abilities Screening Instrument (CASI): a practical test for cross-cultural epidemiological studies of dementia. Int Psychogeriatr. 1994 Spring;6(1):45-58; discussion 62. doi: 10.1017/s1041610294001602. PMID: 8054493.
https://pubmed.ncbi.nlm.nih.gov/8054493/
43. Mini-Mental State Examination (MMSE), March 2024, Healthdirect Australia
https://www.healthdirect.gov.au/mini-mental-state-examination-mmse
44. Guo HJ, Sapra A. Instrumental Activity of Daily Living. [Updated 2022 Nov 14]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan
https://www.ncbi.nlm.nih.gov/books/NBK553126/
45. 4 Signs You Have a Visual Contrast Sensitivity Problem, International Academy of Low Vision Specialists, | February 27, 2022,
https://ialvs.com/4-signs-you-have-a-visual-contrast-sensitivity-problem/
46. Albumin Blood Test, MedlinePlus
https://medlineplus.gov/lab-tests/albumin-blood-test/
47. Wolters FJ, Zonneveld HI, Licher S, Cremers LGM; Heart Brain Connection Collaborative Research Group; Ikram MK, Koudstaal PJ, Vernooij MW, Ikram MA. Hemoglobin and anemia in relation to dementia risk and accompanying changes on brain MRI. Neurology. 2019 Aug 27;93(9):e917-e926. doi: 10.1212/WNL.0000000000008003. Epub 2019 Jul 31. PMID: 31366722; PMCID: PMC6745727.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6745727/
48. Faux NG, Rembach A, Wiley J, Ellis KA, Ames D, Fowler CJ, Martins RN, Pertile KK, Rumble RL, Trounson B, Masters CL; AIBL Research Group; Bush AI. An anemia of Alzheimer's disease. Mol Psychiatry. 2014 Nov;19(11):1227-34. doi: 10.1038/mp.2013.178. Epub 2014 Jan 14. PMID: 24419041
https://pubmed.ncbi.nlm.nih.gov/24419041/
49. Smith AD, Refsum H, Bottiglieri T, Fenech M, Hooshmand B, McCaddon A, Miller JW, Rosenberg IH, Obeid R. Homocysteine and Dementia: An International Consensus Statement. J Alzheimers Dis. 2018;62(2):561-570. doi: 10.3233/JAD-171042. PMID: 29480200; PMCID: PMC5836397.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5836397/
50. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med. 2002 Feb 14;346(7):476-83. doi: 10.1056/NEJMoa011613. PMID: 11844848.
https://www.nejm.org/doi/full/10.1056/NEJMoa011613
51. Gao, L., Zhang, Y., Sterling, K. et al. Brain-derived neurotrophic factor in Alzheimer’s disease and its pharmaceutical potential. Transl Neurodegener 11, 4 (2022). https://doi.org/10.1186/s40035-022-00279-0
https://translationalneurodegeneration.biomedcentral.com/articles/10.1186/s40035-022-00279-0
52. Απεικόνιση του Τανυστή της Διάχυσης (DTI) και Δεσμιδογραφία (Tractography), Α. Μπέκα, Δ. Βεργανελάκης, Π. Τούλας, ΕΛΛΗΝΙΚΗ ΑΚΤΙΝΟΛΟΓΙΑ Τόμος 43, (2):105-115, 2012
https://www.helrad.org/flippingbook/02-12/files/assets/downloads/page0019.pdf
53. Ivanova MV, Zhong A, Turken A, Baldo JV and Dronkers NF (2021) Functional Contributions of the Arcuate Fasciculus to Language Processing. Front. Hum. Neurosci. 15:672665. doi: 10.3389/fnhum.2021.672665
https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2021.672665/full
54. Dalboni da Rocha JL, Bramati I, Coutinho G, Tovar Moll F, Sitaram R. Fractional Anisotropy changes in Parahippocampal Cingulum due to Alzheimer's Disease. Sci Rep. 2020 Feb 14;10(1):2660. doi: 10.1038/s41598-020-59327-2. PMID: 32060334; PMCID: PMC7021702.
ttps://pmc.ncbi.nlm.nih.gov/articles/PMC7021702/
55. Brandalise F, Roda E, Ratto D, Goppa L, Gargano ML, Cirlincione F, Priori EC, Venuti MT, Pastorelli E, Savino E, Rossi P. Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline? J Fungi (Basel). 2023 May 10;9(5):551. doi: 10.3390/jof9050551. PMID: 37233262; PMCID: PMC10218917.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218917/
56. Abdelmoaty, Mai M., Kadry, Rana, Mosley, R. Lee and Gendelman, Howard E.. "Neuroprotective mushrooms" NeuroImmune Pharmacology and Therapeutics, vol. 3, no. 2, 2024, pp. 129-137. https://doi.org/10.1515/nipt-2024-0004
https://www.degruyterbrill.com/document/doi/10.1515/nipt-2024-0004/html
57. Venturella G, Ferraro V, Cirlincione F, Gargano ML. Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials. Int J Mol Sci. 2021 Jan 10;22(2):634. doi: 10.3390/ijms22020634. PMID: 33435246; PMCID: PMC7826851.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7826851
58. Sachchida Nand Rai, Divya Mishra, Payal Singh, Emanuel Vamanu, M.P. Singh, Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases, Biomedicine & Pharmacotherapy, Volume 137, 2021, 111377, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2021.111377.
https://www.sciencedirect.com/science/article/pii/S0753332221001621
59. Li, N.; Li, H.; Liu, Z.; Feng, G.; Shi, C.; Wu, Y. Unveiling the Therapeutic Potentials of Mushroom Bioactive Compounds in Alzheimer’s Disease. Foods 2023, 12, 2972. https://doi.org/10.3390/foods12152972
https://www.mdpi.com/2304-8158/12/15/2972
60. Yanshree; Yu, W.S.; Fung, M.L.; Lee, C.W.; Lim, L.W.; Wong, K.H. The Monkey Head Mushroom and Memory Enhancement in Alzheimer’s Disease. Cells 2022, 11, 2284. https://doi.org/10.3390/cells11152284
https://www.mdpi.com/2073-4409/11/15/2284
61. Vikineswary Sabaratnam, Chia-Wei Phan, Chapter 10 - Neuroactive Components of Culinary and Medicinal Mushrooms With Potential to Mitigate Age-Related Neurodegenerative Diseases, Editor(s): Goutam Brahmachari, In Natural Product Drug Discovery, Discovery and Development of Neuroprotective Agents from Natural Products, Elsevier, 2018, Pages 401-413, ISBN 9780128095935, https://doi.org/10.1016/B978-0-12-809593-5.00010-0.
https://www.sciencedirect.com/science/article/abs/pii/B9780128095935000100
62. Sara Cha, Lynne Bell, Barbara Shukitt-Hale, Claire M. Williams, A review of the effects of mushrooms on mood and neurocognitive health across the lifespan, Neuroscience & Biobehavioral Reviews, Volume 158, 2024, 105548, ISSN 0149-7634, https://doi.org/10.1016/j.neubiorev.2024.105548.
https://www.sciencedirect.com/science/article/pii/S0149763424000162
63. Medicinal Mushrooms Help Fight Cognitive Decline & Protect Your Brain, By Sophie Barret – Hifas da Terra & Patrick Holford, Food for the Brain
https://foodforthebrain.org/medicinal-mushrooms-help-fight-cognitive-decline-protect-your-brain/
64. Lion’s Mane Mushroom, Last updated on July 14, 2025, Alzheimer's Drug Discovery Foundation
https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Lions-Mane-Cognitive-Vitality-For-Researchers.pdf
65. Kim GH, Shim JO. Gut microbiota affects brain development and behavior. Clin Exp Pediatr. 2023 Jul;66(7):274-280. doi: 10.3345/cep.2021.01550. Epub 2022 Nov 8. PMID: 36397259; PMCID: PMC10331547.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10331547/
66. Loh, J.S., Mak, W.Q., Tan, L.K.S. et al. Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases. Sig Transduct Target Ther 9, 37 (2024). https://doi.org/10.1038/s41392-024-01743-1
https://www.nature.com/articles/s41392-024-01743-1
67. Fu J, Qin Y, Xiao L and Dai X (2024) Causal relationship between gut microflora and dementia: a Mendelian randomization study. Front. Microbiol. 14:1306048. doi: 10.3389/fmicb.2023.1306048
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2023.1306048/full
68. Seo, Do., Holtzman, D.M. Current understanding of the Alzheimer’s disease-associated microbiome and therapeutic strategies. Exp Mol Med 56, 86–94 (2024). https://doi.org/10.1038/s12276-023-01146-2
https://www.nature.com/articles/s12276-023-01146-2
69. Professor Sandrine Thuret Dr. rer. nat. FHEA Professor of Neuroscience, King’s College London, 18 October 2023 Scientists discover links between Alzheimer's disease and gut microbiota
https://www.kcl.ac.uk/news/links-between-alzheimers-and-gut-microbiota
70. Bid to prevent gut bacteria triggering Alzheimer’s, Michelle Wisbey 21 May 2024, The Royal Australian College of General Practitioners
https://www1.racgp.org.au/newsgp/clinical/bid-to-prevent-gut-bacteria-triggering-alzheimer-s
71. Changes in human microbiome precede Alzheimer’s cognitive declines From NIH Director’s Blog
ttps://www.alzheimers.gov/news/changes-human-microbiome-precede-alzheimers-cognitive-declines
72. Dementia Australia TM Research Foundation, Research Project By Dr Andrew Shoubridge, Reducing the risk of dementia by keeping gut microbiome healthy
https://www.dementia.org.au/sites/default/files/2024-04/ResearchSheet_DrAndrewShoubridge-2021.pdf
73. Jin, Y., He, J., Fan, D. et al. Application of edible fungi in gut microbiota regulation. npj Sci Food 10, 24 (2026). https://doi.org/10.1038/s41538-025-00671-w
https://www.nature.com/articles/s41538-025-00671-w
74. Zhao J, Hu Y, Qian C, Hussain M, Liu S, Zhang A, He R, Sun P. The Interaction between Mushroom Polysaccharides and Gut Microbiota and Their Effect on Human Health: A Review. Biology (Basel). 2023 Jan 12;12(1):122. doi: 10.3390/biology12010122. PMID: 36671814; PMCID: PMC9856211.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9856211/
75. Yu, C.; Dong, Q.; Chen, M.; Zhao, R.; Zha, L.; Zhao, Y.; Zhang, M.; Zhang, B.; Ma, A. The Effect of Mushroom Dietary Fiber on the Gut Microbiota and Related Health Benefits: A Review. J. Fungi 2023, 9, 1028. https://doi.org/10.3390/jof9101028
https://www.mdpi.com/2309-608X/9/10/1028
76. Zhao Q, Jiang Y, Zhao Q, Patrick Manzi H, Su L, Liu D, Huang X, Long D, Tang Z and Zhang Y (2023) The benefits of edible mushroom polysaccharides for health and their influence on gut microbiota: a review. Front. Nutr. 10:1213010. doi: 10.3389/fnut.2023.1213010
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1213010/full
77. Francis Ayimbila, Suttipun Keawsompong, Unveiling the prebiotic properties of mushrooms in improving gut health and related diseases, Food Bioscience, Volume 70, 2025, 107040, ISSN 2212-4292, https://doi.org/10.1016/j.fbio.2025.107040.
https://www.sciencedirect.com/science/article/abs/pii/S2212429225012167
78. Emerging Role of Mushrooms in Gut Microbiome Revolution September 2024 Authors: Aditya Bhatia
https://www.researchgate.net/publication/384609876_Emerging_Role_of_Mushrooms_in_Gut_Microbiome_Revolution
79. Miaoyu Li, Leilei Yu, Jianxin Zhao, Hao Zhang, Wei Chen, Qixiao Zhai, Fengwei Tian, Role of dietary edible mushrooms in the modulation of gut microbiota, Journal of Functional Foods, Volume 83, 2021, 104538, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2021.104538.
https://www.sciencedirect.com/science/article/pii/S1756464621001870
80. Jayachandran M, Xiao J, Xu B. A Critical Review on Health Promoting Benefits of Edible Mushrooms through Gut Microbiota. Int J Mol Sci. 2017 Sep 8;18(9):1934. doi: 10.3390/ijms18091934. PMID: 28885559; PMCID: PMC5618583.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5618583/
81. Xie XQ, Geng Y, Guan Q, Ren Y, Guo L, Lv Q, Lu ZM, Shi JS, Xu ZH. Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study. Nutrients. 2021 Mar 21;13(3):1008. doi: 10.3390/nu13031008. PMID: 33800983; PMCID: PMC8004025.
https://pubmed.ncbi.nlm.nih.gov/33800983/
82. Compounds for dementia from Hericium erinaceum, Drugs of the Future 2008, 33(2): 149-155 © 2008 Prous Science, S.A.U. or its licensors. All rights reserved. CCC: 0377-8282/2008 DOI: 10.1358/dof.2008.033.02.1173290 Review Article, Hirokazu Kawagishi1,2,* , Cun Zhuang
https://www.creopharm.com.ua/articles_cebrofit/articles_cebrofit_3.pdf
E1. Li IC, Lee LY, Tzeng TT, Chen WP, Chen YP, Shiao YJ, Chen CC. Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines. Behav Neurol. 2018 May 21;2018:5802634. doi: 10.1155/2018/5802634. PMID: 29951133; PMCID: PMC5987239.
https://pubmed.ncbi.nlm.nih.gov/29951133/
E2. Yadav SK, Ir R, Jeewon R, Doble M, Hyde KD, Kaliappan I, Jeyaraman R, Reddi RN, Krishnan J, Li M, Durairajan SSK. A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders. Planta Med. 2020 Nov;86(16):1161-1175. doi: 10.1055/a-1177-4834. Epub 2020 Jul 14. PMID: 32663897.
https://pubmed.ncbi.nlm.nih.gov/32663897
E3. Rai SN, Mishra D, Singh P, Vamanu E, Singh MP. Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases. Biomed Pharmacother. 2021 May;137:111377. doi: 10.1016/j.biopha.2021.111377. Epub 2021 Feb 15. PMID: 33601145.
https://pubmed.ncbi.nlm.nih.gov/33601145
E4. Lewis JE, Poles J, Shaw DP, Karhu E, Khan SA, Lyons AE, Sacco SB, McDaniel HR. The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review. J Clin Transl Res. 2021 Aug 4;7(4):575-620. PMID: 34541370; PMCID: PMC8445631.
https://pubmed.ncbi.nlm.nih.gov/34541370
E5. Trovato Salinaro A, Pennisi M, Di Paola R, Scuto M, Crupi R, Cambria MT, Ontario ML, Tomasello M, Uva M, Maiolino L, Calabrese EJ, Cuzzocrea S, Calabrese V. Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer's disease and Alzheimer-linked pathologies: modulation by nutritional mushrooms. Immun Ageing. 2018 Feb 14;15:8. doi: 10.1186/s12979-017-0108-1. PMID: 29456585; PMCID: PMC5813410.
https://pubmed.ncbi.nlm.nih.gov/29456585
E6. Gregory J, Vengalasetti YV, Bredesen DE, Rao RV. Neuroprotective Herbs for the Management of Alzheimer's Disease. Biomolecules. 2021 Apr 8;11(4):543. doi: 10.3390/biom11040543. PMID: 33917843; PMCID: PMC8068256.
https://pubmed.ncbi.nlm.nih.gov/33917843
E7. Phan CW, David P, Naidu M, Wong KH, Sabaratnam V. Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism. Crit Rev Biotechnol. 2015;35(3):355-68. doi: 10.3109/07388551.2014.887649. PMID: 24654802.
https://pubmed.ncbi.nlm.nih.gov/24654802/
E8. Hetland G, Tangen JM, Mahmood F, Mirlashari MR, Nissen-Meyer LSH, Nentwich I, Therkelsen SP, Tjønnfjord GE, Johnson E. Antitumor, Anti-Inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifolafrondosa: A Review of Preclinical and Clinical Studies. Nutrients. 2020 May 8;12(5):1339. doi: 10.3390/nu12051339. PMID: 32397163; PMCID: PMC7285126.
https://pubmed.ncbi.nlm.nih.gov/32397163/
E9. Jiang S, Wang S, Sun Y, Zhang Q. Medicinal properties of Hericium erinaceus and its potential to formulate novel mushroom-based pharmaceuticals. Appl Microbiol Biotechnol. 2014 Sep;98(18):7661-70. doi: 10.1007/s00253-014-5955-5. Epub 2014 Jul 29. PMID: 25070597.
https://pubmed.ncbi.nlm.nih.gov/25070597
E10. He X, Wang X, Fang J, Chang Y, Ning N, Guo H, Huang L, Huang X, Zhao Z. Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion's Mane) mushroom: A review. Int J Biol Macromol. 2017 Apr;97:228-237. doi: 10.1016/j.ijbiomac.2017.01.040. Epub 2017 Jan 10. PMID: 28087447.
https://pubmed.ncbi.nlm.nih.gov/28087447/
E11. Friedman M. Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds. J Agric Food Chem. 2015 Aug 19;63(32):7108-23. doi: 10.1021/acs.jafc.5b02914. Epub 2015 Aug 5. PMID: 26244378.
https://pubmed.ncbi.nlm.nih.gov/26244378/
E12. Chong PS, Fung ML, Wong KH, Lim LW. Therapeutic Potential of Hericium erinaceus for Depressive Disorder. Int J Mol Sci. 2019 Dec 25;21(1):163. doi: 10.3390/ijms21010163. PMID: 31881712; PMCID: PMC6982118.
https://pubmed.ncbi.nlm.nih.gov/31881712/
E13. Jiang S, Wang S, Sun Y, Zhang Q. Medicinal properties of Hericium erinaceus and its potential to formulate novel mushroom-based pharmaceuticals. Appl Microbiol Biotechnol. 2014 Sep;98(18):7661-70. doi: 10.1007/s00253-014-5955-5. Epub 2014 Jul 29. PMID: 25070597.
https://pubmed.ncbi.nlm.nih.gov/25070597/
E14. Chen J, Zeng X, Yang YL, Xing YM, Zhang Q, Li JM, Ma K, Liu HW, Guo SX. Genomic and transcriptomic analyses reveal differential regulation of diverse terpenoid and polyketides secondary metabolites in Hericium erinaceus. Sci Rep. 2017 Aug 31;7(1):10151. doi: 10.1038/s41598-017-10376-0. PMID: 28860534; PMCID: PMC5579188.
https://pubmed.ncbi.nlm.nih.gov/28860534/
E15. Khan MA, Tania M, Liu R, Rahman MM. Hericium erinaceus: an edible mushroom with medicinal values. J Complement Integr Med. 2013 May 24;10:/j/jcim.2013.10.issue-1/jcim-2013-0001/jcim-2013-0001.xml. doi: 10.1515/jcim-2013-0001. PMID: 23735479.
https://pubmed.ncbi.nlm.nih.gov/23735479/
E16. Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, Ohnuki K. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res. 2010 Aug;31(4):231-7. doi: 10.2220/biomedres.31.231. PMID: 20834180.
https://pubmed.ncbi.nlm.nih.gov/20834180/
E17. Saitsu Y, Nishide A, Kikushima K, Shimizu K, Ohnuki K. Improvement of cognitive functions by oral intake of Hericium erinaceus. Biomed Res. 2019;40(4):125-131. doi: 10.2220/biomedres.40.125. PMID: 31413233.
https://pubmed.ncbi.nlm.nih.gov/31413233/
E18. Li IC, Chang HH, Lin CH, Chen WP, Lu TH, Lee LY, Chen YW, Chen YP, Chen CC, Lin DP. Prevention of Early Alzheimer's Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study. Front Aging Neurosci. 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PMID: 32581767; PMCID: PMC7283924.
https://pubmed.ncbi.nlm.nih.gov/32581767/
E19. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytotherapy Research : PTR. 2009 Mar;23(3):367-372. DOI: 10.1002/ptr.2634. PMID: 18844328.
https://europepmc.org/article/MED/18844328
Απώλεια βάρους
1. Łysakowska, Paulina & Sobota, A. & Wirkijowska, A.. (2023). Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review. Molecules. 28. 10.3390/molecules28145393.
https://www.researchgate.net/publication/372344884_Medicinal_Mushrooms_Their_Bioactive_Components_Nutritional_Value_and_Application_in_Functional_Food_Production-A_Review
2. Ganesan K, Xu B. Anti-Obesity Effects of Medicinal and Edible Mushrooms. Molecules. 2018 Nov 5;23(11):2880. doi: 10.3390/molecules23112880. PMID: 30400600; PMCID: PMC6278646.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6278646/
3. Precious U. Ezurike, Evelyn Odunola, Tolulope A. Oke, Adewale G. Bakre, Oluwayimika Olumide, OgoOluwa Odetoye, Adenike M. Alege, Oyindamola O. Abiodun, Ganoderma lucidum ethanol extract promotes weight loss and improves depressive-like behaviors in male and female Swiss mice, Physiology & Behavior, Volume 265, 2023, 114155, ISSN 0031-9384, https://doi.org/10.1016/j.physbeh.2023.114155.
https://www.sciencedirect.com/science/article/abs/pii/S0031938423000835
4. Eshita Sharma, Rakesh Bairwa, Priyanka Lal, Sudeepta Pattanayak, Kota Chakrapani, Rajendra Poorvasandhya, Awadhesh Kumar, Muhammad Ahsan Altaf, Rahul Kumar Tiwari, Milan Kumar Lal, Ravinder Kumar, Edible mushrooms trending in food: Nutrigenomics, bibliometric, from bench to valuable applications, Heliyon, Volume 10, Issue 17, 2024, e36963, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2024.e36963.
https://www.sciencedirect.com/science/article/pii/S2405844024129945
5. Choi WS, Kim YS, Park BS, Kim JE, Lee SE. Hypolipidaemic Effect of Hericium erinaceum Grown in Artemisia capillaris on Obese Rats. Mycobiology. 2013 Jun;41(2):94-9. doi: 10.5941/MYCO.2013.41.2.94. Epub 2013 Jun 30. PMID: 23874132; PMCID: PMC3714447.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3714447/
6. Mushroom coffee: Worth a taste? June 4, 2024 By Lindsay Warner, Content Licensing Editor, Harvard Health Publishing
https://www.health.harvard.edu/nutrition/mushroom-coffee-worth-a-taste
7. Grozier CD, Alves VA, Killen LG, Simpson JD, O'Neal EK, Waldman HS. Four Weeks of Hericium erinaceus Supplementation Does Not Impact Markers of Metabolic Flexibility or Cognition. Int J Exerc Sci. 2022 Oct 1;15(2):1366-1380. doi: 10.70252/XZKO8571. PMID: 36582308; PMCID: PMC9762243.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9762243/
8. Teja KS, Suruchi, Rai U, Kumar M, Mohanty O, Roy J, Meshram S. Mushrooms: A Potential Option in the Management of Deficiency and Diseases in Humans. J Pure Appl Microbiol. 2023;17(2):749-760. doi: 10.22207/JPAM.17.2.55
https://microbiologyjournal.org/mushrooms-a-potential-option-in-the-management-of-deficiency-and-diseases-in-humans/
9. Alvandi, H., Ansari, E. ., Kianirad, S. ., Hatamian-Zarmi, A., Mokhtari Hosseini, Z. B., & Ebrahimi-Hosseinzadeh, B. (2022). Medicinal mushrooms as potential therapeutic agents in the treatment of diabetes mellitus: a review with focusing on in vivo and clinical studies. Italian Journal of Mycology, 51(1), 75–96. https://doi.org/10.6092/issn.2531-7342/15023
https://italianmycology.unibo.it/article/view/15023
10. Guggenheim AG, Wright KM, Zwickey HL. Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology. Integr Med (Encinitas). 2014 Feb;13(1):32-44. PMID: 26770080; PMCID: PMC4684115.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4684115/
11. Medicinal Mushrooms (PDQ®)–Patient Version, July 11, 2024, National Cancer Institute, U.S. Department of Health and Human Services
https://www.cancer.gov/about-cancer/treatment/cam/patient/mushrooms-pdq
12. Karuppusamy Arunachalam, Sreeja Puthanpura Sasidharan, Xuefei Yang, A concise review of mushrooms antiviral and immunomodulatory properties that may combat against COVID-19, Food Chemistry Advances, Volume 1, 2022, 100023, ISSN 2772-753X, https://doi.org/10.1016/j.focha.2022.100023.
https://www.sciencedirect.com/science/article/pii/S2772753X22000120
13. Do Mushroom Supplements Boost Immunity Against Cancer? Share By Susan Wagner Tuesday, October 22, 2024, Memorial Sloan Kettering Cancer Center
https://www.mskcc.org/news/do-mushroom-supplements-boost-immunity-against-cancer
14. Ruth W. Mwangi, John M. Macharia, Isabel N. Wagara, Raposa L. Bence, The antioxidant potential of different edible and medicinal mushrooms, Biomedicine & Pharmacotherapy, Volume 147, 2022, 112621, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2022.112621.
https://www.sciencedirect.com/science/article/pii/S0753332222000099
15. Podkowa, A., Kryczyk-Poprawa, A., Opoka, W. et al. Culinary–medicinal mushrooms: a review of organic compounds and bioelements with antioxidant activity. Eur Food Res Technol 247, 513–533 (2021). https://doi.org/10.1007/s00217-020-03646-1
https://link.springer.com/article/10.1007/s00217-020-03646-1
16. Elsayed EA, El Enshasy H, Wadaan MA, Aziz R. Mushrooms: a potential natural source of anti-inflammatory compounds for medical applications. Mediators Inflamm. 2014;2014:805841. doi: 10.1155/2014/805841. Epub 2014 Nov 23. PMID: 25505823; PMCID: PMC4258329.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4258329/
17. Drzewiecka, B.; Wessely-Szponder, J.; Świeca, M.; Espinal, P.; Fusté, E.; Fernández-De La Cruz, E. Bioactive Peptides and Other Immunomodulators of Mushroom Origin. Biomedicines 2024, 12, 1483. https://doi.org/10.3390/biomedicines12071483
https://www.mdpi.com/2227-9059/12/7/1483
18. Manna P, Jain SK. Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies. Metab Syndr Relat Disord. 2015 Dec;13(10):423-44. doi: 10.1089/met.2015.0095. PMID: 26569333; PMCID: PMC4808277.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4808277/
19. Theresa V. Rohm, Daniel T. Meier, Jerrold M. Olefsky, Marc Y. Donath, Inflammation in obesity, diabetes, and related disorders, Immunity, Volume 55, Issue 1, 2022, Pages 31-55, ISSN 1074-7613, https://doi.org/10.1016/j.immuni.2021.12.013.
https://www.sciencedirect.com/science/article/pii/S1074761321005495
20. Bilal, Ahmad & Wani, Bilal & Bodha, R & Wani, Ab. Hamid. (2010). Nutritional and medicinal importance of mushrooms. Journal of Medicinal Plants Research. 4. 10.5897/JMPR09.565.
https://www.researchgate.net/publication/266012160_Nutritional_and_medicinal_importance_of_mushrooms
21. Holmes, D. Medicinal mushroom reduces obesity by modulating microbiota. Nat Rev Endocrinol 11, 504 (2015). https://doi.org/10.1038/nrendo.2015.114
https://www.nature.com/articles/nrendo.2015.114#citeas
22. Stamatia-Angeliki Kleftaki, Stamatia Simati, Charalampia Amerikanou, Aristea Gioxari, Chara Tzavara, Georgios I. Zervakis, Nick Kalogeropoulos, Alexander Kokkinos, Andriana C. Kaliora, Pleurotus eryngii improves postprandial glycaemia, hunger and fullness perception, and enhances ghrelin suppression in people with metabolically unhealthy obesity, Pharmacological Research, Volume 175, 2022, 105979, ISSN 1043-6618, https://doi.org/10.1016/j.phrs.2021.105979.
https://www.sciencedirect.com/science/article/abs/pii/S1043661821005636
23. Németh, Z.; Paulinné Bukovics, M.; Sümegi, L.D.; Sturm, G.; Takács, I.; Simon-Szabó, L. The Importance of Edible Medicinal Mushrooms and Their Potential Use as Therapeutic Agents Against Insulin Resistance. Int. J. Mol. Sci. 2025, 26, 827. https://doi.org/10.3390/ijms26020827
https://www.mdpi.com/1422-0067/26/2/827
24. Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, Ohnuki K. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res. 2010 Aug;31(4):231-7. doi: 10.2220/biomedres.31.231. PMID: 20834180.
https://pubmed.ncbi.nlm.nih.gov/20834180/
25. Volume 1, Issue 2 (November 2022), Health Science Monitor 2022, 1(2): 107-108 Does Ganoderma lucidum reduce obesity? Ameneh Marzban , Abdolrazagh Marzban , Payam Emami * Department of Emergency Medical Sciences, School of Paramedical Sciences, Kurdistan University of Medical Sciences, Sanandaj, Iran
https://hsm.umsu.ac.ir/browse.php?a_id=46&sid=1&slc_lang=en
26. Son EH, Jung DH, Shin H, Lee S, Kim Y, Lim HS. Effects of the Intestinal Status and Clinical Factors of Korean Middle-Aged People Through the Consumption of Functional Foods Containing Auricularia auricula-judae Powder: Prospective, Randomized, Open-Label, and Control Comparative Trial. Clin Nutr Res. 2025 Jan 22;14(1):7-16. doi: 10.7762/cnr.2025.14.1.7. PMID: 39968271; PMCID: PMC11832288.
https://pubmed.ncbi.nlm.nih.gov/39968271/
27. Nutrients. 2021 Mar 21;13(3):1008. doi: 10.3390/nu13031008. Influence of Short-Term Consumption of Hericium erinaceus on Serum Biochemical Markers and the Changes of the Gut Microbiota: A Pilot Study Xiao-Qian Xie, Yan Geng, Qijie Guan, Yilin Ren, Lin Guo, Qiqi Lv, Zhen-Ming Lu, Jin-Song Shi, Zheng-Hong Xu.
https://pubmed.ncbi.nlm.nih.gov/33800983/
28. Gut microbiome makeup can determine ability to lose weight, UCLA Health, November 24, 2021
https://www.uclahealth.org/news/article/gut-microbiome-makeup-can-determine-ability-to-lose-weight
29. Jian, C., Silvestre, M.P., Middleton, D. et al. Gut microbiota predicts body fat change following a low-energy diet: a PREVIEW intervention study. Genome Med 14, 54 (2022). https://doi.org/10.1186/s13073-022-01053-7
https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-022-01053-7
30. Małgorzata Moszak, Marta Pelczyńska, Agnieszka Wesołek, Dominika Stenclik, Paweł Bogdański, Does gut microbiota affect the success of weight loss? Evidence and speculation, Nutrition, Volume 116, 2023, 112111, ISSN 0899-9007, https://doi.org/10.1016/j.nut.2023.112111.
https://www.sciencedirect.com/science/article/pii/S0899900723001405
31. Li, H., Zhang, L., Li, J. et al. Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota. Nat Metab 6, 578–597 (2024). https://doi.org/10.1038/s42255-024-00988-y
https://www.nature.com/articles/s42255-024-00988-y
Ανθεκτική υπέρταση
1. Resistant Hypertension, The Johns Hopkins University
https://www.hopkinsmedicine.org/health/conditions-and-diseases/high-blood-pressure-hypertension/resistant-hypertension
2. Faconti, L., George, J., Partridge, S. et al. Investigation and management of resistant hypertension: British and Irish Hypertension Society position statement. J Hum Hypertens 39, 1–14 (2025). https://doi.org/10.1038/s41371-024-00983-6
https://www.nature.com/articles/s41371-024-00983-6
3. Carey RM, Calhoun DA, Bakris GL, Brook RD, Daugherty SL, Dennison-Himmelfarb CR, Egan BM, Flack JM, Gidding SS, Judd E, Lackland DT, Laffer CL, Newton-Cheh C, Smith SM, Taler SJ, Textor SC, Turan TN, White WB; American Heart Association Professional/Public Education and Publications Committee of the Council on Hypertension; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Genomic and Precision Medicine; Council on Peripheral Vascular Disease; Council on Quality of Care and Outcomes Research; and Stroke Council. Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association. Hypertension. 2018 Nov;72(5):e53-e90. doi: 10.1161/HYP.0000000000000084. PMID: 30354828; PMCID: PMC6530990.
https://www.ahajournals.org/doi/10.1161/HYP.0000000000000084
4. Natale, F.; Franzese, R.; Luisi, E.; Mollo, N.; Marotta, L.; Solimene, A.; D’Elia, S.; Golino, P.; Cimmino, G. The Increasing Problem of Resistant Hypertension: We’ll Manage till Help Comes! Med. Sci. 2024, 12, 53. https://doi.org/10.3390/medsci12040053
https://www.mdpi.com/2076-3271/12/4/53
5. Daugherty SL, Powers JD, Magid DJ, Tavel HM, Masoudi FA, Margolis KL, O'Connor PJ, Selby JV, Ho PM. Incidence and prognosis of resistant hypertension in hypertensive patients. Circulation. 2012 Apr 3;125(13):1635-42. doi: 10.1161/CIRCULATIONAHA.111.068064. Epub 2012 Feb 29. PMID: 22379110; PMCID: PMC3343635.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3343635/
6. White, W., Turan, T., Textor, S., Taler, S., Smith, S., Newton-Cheh, C., Laffer, C., Lackland, D., Judd, E., Gidding, S., Flack, J., Egan, B., Dennison-Himmelfarb, C., Daugherty, S., Brook, R., Bakris, G., Calhoun, D., & Carey, R. (2018). Resistant Hypertension: Detection, Evaluation, and Management A Scientific Statement From the American Heart Association. Hypertension, 72(5), e53-e90. https://doi.org/10.1161/HYP.0000000000000084
https://www.ovid.com/journals/hype/abstract/10.1161/hyp.0000000000000084~resistant-hypertension-detection-evaluation-and-management-a?redirectionsource=fulltextview
Σκλήρυνση κατά πλάκας
1. Multiple Sclerosis, national institutes of neurological disorders and stroke
https://www.ninds.nih.gov/health-information/disorders/multiple-sclerosis
2. Podbielska M, Banik NL, Kurowska E, Hogan EL. Myelin recovery in multiple sclerosis: the challenge of remyelination. Brain Sci. 2013 Aug 28;3(3):1282-324. doi: 10.3390/brainsci3031282. PMID: 24961530; PMCID: PMC4061877.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4061877/
3. David S. Younger, Chapter 6 - Multiple sclerosis: Motor dysfunction, Editor(s): David S. Younger, Handbook of Clinical Neurology, Elsevier, Volume 196, 2023, Pages 119-147, ISSN 0072-9752, ISBN 9780323988179, https://doi.org/10.1016/B978-0-323-98817-9.00016-8.
https://www.sciencedirect.com/science/chapter/handbook/pii/B9780323988179000168
4. Taranu, D., Balz, L.T., Holbrook, J. et al. Cognitive impairment, mood, and fatigue in various multiple sclerosis subtypes: a one-year follow-up study. J Neurol 272, 398 (2025). https://doi.org/10.1007/s00415-025-13115-y
https://link.springer.com/article/10.1007/s00415-025-13115-y
5. Braley TJ, Chervin RD. Fatigue in multiple sclerosis: mechanisms, evaluation, and treatment. Sleep. 2010 Aug;33(8):1061-7. doi: 10.1093/sleep/33.8.1061. PMID: 20815187; PMCID: PMC2910465.
https://pmc.ncbi.nlm.nih.gov/articles/PMC2910465/
6. Ashtari F, Shaygannejad V, Farajzadegan Z, Amin A. Does early-onset multiple sclerosis differ from adult-onset form in Iranian people. J Res Med Sci. 2010 Mar;15(2):94-9. PMID: 21526065; PMCID: PMC3082796.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3082796/
7. Harbo HF, Gold R, Tintoré M. Sex and gender issues in multiple sclerosis. Ther Adv Neurol Disord. 2013 Jul;6(4):237-48. doi: 10.1177/1756285613488434. PMID: 23858327; PMCID: PMC3707353.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3707353/
8. D’Anca, M.; Buccellato, F.R.; Tartaglia, G.M.; Del Fabbro, M.; Muti, P.; Scarpini, E.; Galimberti, D.; Ghezzi, L. Why Is Multiple Sclerosis More Frequent in Women? Role of the Immune System and of Oral and Gut Microbiota. Appl. Sci. 2023, 13, 5881. https://doi.org/10.3390/app13105881
https://www.mdpi.com/2076-3417/13/10/5881
9. Time to reconsider the classification of multiple sclerosis Yamamura, Takashi The Lancet Neurology, Volume 22, Issue 1, 6 - 8
https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(22)00469-0/abstract
10. Walton C, King R, Rechtman L, Kaye W, Leray E, Marrie RA, Robertson N, La Rocca N, Uitdehaag B, van der Mei I, Wallin M, Helme A, Angood Napier C, Rijke N, Baneke P. Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition. Mult Scler. 2020 Dec;26(14):1816-1821. doi: 10.1177/1352458520970841. Epub 2020 Nov 11. PMID: 33174475; PMCID: PMC7720355.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7720355/
11. Khan, G., Hashim, M.J. Epidemiology of Multiple Sclerosis: Global, Regional, National and Sub-National-Level Estimates and Future Projections. J Epidemiol Glob Health 15, 21 (2025). https://doi.org/10.1007/s44197-025-00353-6
https://link.springer.com/article/10.1007/s44197-025-00353-6
12. Guerra, T.; Iaffaldano, P. A Window into New Insights on Progression Independent of Relapse Activity in Multiple Sclerosis: Role of Therapies and Current Perspective. Int. J. Mol. Sci. 2025, 26, 884. https://doi.org/10.3390/ijms26030884
https://www.mdpi.com/1422-0067/26/3/884
13. Boutitah-Benyaich, I., Eixarch, H., Villacieros-Álvarez, J. et al. Multiple sclerosis: molecular pathogenesis and therapeutic intervention. Sig Transduct Target Ther 10, 324 (2025). https://doi.org/10.1038/s41392-025-02415-4
https://www.nature.com/articles/s41392-025-02415-4
14. Ferrè L, Filippi M and Esposito F (2020) Involvement of Genetic Factors in Multiple Sclerosis. Front. Cell. Neurosci. 14:612953. doi: 10.3389/fncel.2020.612953
https://www.frontiersin.org/journals/cellular-neuroscience/articles/10.3389/fncel.2020.612953/full
15. Multiple Sclerosis, national institutes of neurological disorders and stroke
https://www.ninds.nih.gov/health-information/disorders/multiple-sclerosis
16. What Causes MS? National Multiple Sclerosis Society
https://www.nationalmssociety.org/understanding-ms/what-is-ms/what-causes-ms
17. Who develops MS? Nationalmssociety
https://www.nationalmssociety.ae/en/about-ms/who-develops-ms/
18. Is MS a genetic or hereditary condition? Multiple Sclerosis Society (MS Society UK)
https://www.mssociety.org.uk/about-ms/what-is-ms/causes-of-ms
19. Wingerchuk DM. Smoking: effects on multiple sclerosis susceptibility and disease progression. Ther Adv Neurol Disord. 2012 Jan;5(1):13-22. doi: 10.1177/1756285611425694. PMID: 22276073; PMCID: PMC3251901.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3251901/
20. Nishanth K, Tariq E, Nzvere FP, Miqdad M, Cancarevic I. Role of Smoking in the Pathogenesis of Multiple Sclerosis: A Review Article. Cureus. 2020 Aug 5;12(8):e9564. doi: 10.7759/cureus.9564. PMID: 32905534; PMCID: PMC7473606.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7473606/
21. Borros Arneth, Multiple Sclerosis and Smoking, The American Journal of Medicine, Volume 133, Issue 7, 2020, Pages 783-788, ISSN 0002-9343, https://doi.org/10.1016/j.amjmed.2020.03.008.
https://www.sciencedirect.com/science/article/abs/pii/S000293432030228X
22. Manouchehrinia A, Huang J, Hillert J, Alfredsson L, Olsson T, Kockum I and Constantinescu CS (2022) Smoking Attributable Risk in Multiple Sclerosis. Front. Immunol. 13:840158. doi: 10.3389/fimmu.2022.840158
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.840158/full
23. Wang JH, van Haselen R, Wang M, Yang GL, Zhang Z, Friedrich ME, Wang LQ, Zhou YQ, Yin M, Xiao CY, Duan AL, Liu SC, Chen B, Liu JP. Acupuncture for smoking cessation: A systematic review and meta-analysis of 24 randomized controlled trials. Tob Induc Dis. 2019 Jun 4;17:48. doi: 10.18332/tid/109195. PMID: 31516491; PMCID: PMC6662782.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6662782/
24. Wang YY, Liu Z, Chen F, Sun L, Wu Y, Yang JS, Fang JL. Effects of acupuncture on craving after tobacco cessation: a resting-state fMRI study based on the fractional amplitude of low-frequency fluctuation. Quant Imaging Med Surg 2019;9(6):1118-1125. doi: 10.21037/qims.2019.06.07
https://qims.amegroups.org/article/view/26723/html
25. Is it Possible to Quit Smoking With Acupuncture? 09 October 2024, Yeditepe University Hospital
https://yeditepehastaneleri.com/en/health-guide/complementary-medicine/it-possible-quit-smoking-acupuncture
26. Cleveland Clinic, Want to Quit Smoking? Acupuncture Can Help You With Cravings
https://health.clevelandclinic.org/want-to-quit-smoking-acupuncture-can-help-you-with-cravings
27. Smith R. “Let food be thy medicine...”. BMJ. 2004 Jan 24;328(7433):0. PMCID: PMC318470.
https://pmc.ncbi.nlm.nih.gov/articles/PMC318470/
28. Devries S, Willett W, Bonow RO. Nutrition Education in Medical School, Residency Training, and Practice. JAMA. 2019 Apr 9;321(14):1351-1352. doi: 10.1001/jama.2019.1581. PMID: 30896728.
https://greatmed.org/wp-content/uploads/2022/12/Devries-et-al.Nutr-Edu-Residency.2019.JAMA_.pdf
29. May 3, 2018 How much does your doctor actually know about nutrition? By American Heart Association News
https://www.heart.org/en/news/2018/05/03/how-much-does-your-doctor-actually-know-about-nutrition
30. The Deficit of Nutrition Education of Physicians Aggarwal, Monica et al. The American Journal of Medicine, Volume 131, Issue 4, 339 - 345
https://www.amjmed.com/article/S0002-9343(17)31229-9/fulltext
31. Khiri, N. and Howells, K. (2025), Nutritional Education in Medical Curricula and Clinical Practice: A Scoping Review on the Knowledge Deficit Amongst Medical Students and Doctors. Journal of Human Nutrition and Dietetics, 38: e70031. https://doi.org/10.1111/jhn.70031
https://onlinelibrary.wiley.com/doi/full/10.1111/jhn.70031
32. Aggarwal M, Singh Ospina N, Kazory A, Joseph I, Zaidi Z, Ataya A, Agito M, Bubb M, Hahn P, Sattari M. The Mismatch of Nutrition and Lifestyle Beliefs and Actions Among Physicians: A Wake-Up Call. Am J Lifestyle Med. 2019 Nov 5;14(3):304-315. doi: 10.1177/1559827619883603. PMID: 32477033; PMCID: PMC7232894.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7232894/
33. Ocampo-Ordóñez, M.B., Headley, I., Arévalo-Alvear, E.S. et al. Clinical and surgical physician’s perception of nutrition knowledge. BMC Prim. Care 25, 282 (2024). https://doi.org/10.1186/s12875-024-02534-x
https://link.springer.com/article/10.1186/s12875-024-02534-x
34. Most doctors lack adequate training to give informed diet advice Lauren Vogel CMAJ Aug 2018, 190 (31) E945; DOI: 10.1503/cmaj.109-5639
https://www.cmaj.ca/content/190/31/e945
35. Stanford University, Why Medical Schools Need to Focus More on Nutrition This piece appeared in The Wall Street Journal on October 10, 2019. Nutrition BY LLOYD MINOR
https://med.stanford.edu/school/leadership/dean/precision-health-in-the-news/why-medica-schools-need-focus-nutrition.html
36. An area where we can’t neglect nutrition 15 October 2019, University of Auckland
https://www.auckland.ac.nz/en/news/2019/10/15/area-where-we-cant-neglect-nutrition.html
37. Diet and Multiple Sclerosis, National Multiple Sclerosis Society
https://www.nationalmssociety.org/managing-ms/living-with-ms/diet-exercise-and-healthy-behaviors/diet-nutrition
38. Hatami A, Ahmadi-khorram M, Keykhaei F, Esfehani AJ, Nematy M. Association Between the Risk of Multiple Sclerosis and Dietary Proinflammatory/Anti-Inflammatory Food Intake and Dietary Diversity: A Case-Control Study. Clin Nutr Res. 2024 Jan;13(1):61-73. https://doi.org/10.7762/cnr.2024.13.1.61
https://e-cnr.org/DOIx.php?id=10.7762/cnr.2024.13.1.61
39. Rosso, R.; Maglione, A.; Bronzini, M.; Virgilio, E.; Clerico, M.; Rolla, S. Linking Nutrients to Multiple Sclerosis Pathogenesis: Biological Evidence and Clinical Implications. Nutrients 2025, 17, 3414. https://doi.org/10.3390/nu17213414
https://www.mdpi.com/2072-6643/17/21/3414
40. “I see diet almost as another disease modifying therapy. It’s that important.” A qualitative study of dietitian and nursing perspectives on the role of diet and brain health for multiple sclerosis Ware-Maloney, Emma et al. Multiple Sclerosis and Related Disorders, Volume 102, 106613
https://www.msard-journal.com/article/S2211-0348(25)00355-4/fulltext
41. MS Patient’s Pick of the Week’s News: Remyelination, Ocrevus, Mushrooms, Heparin, Exercise admin avatar by admin | October 17, 2016
https://multiplesclerosisnewstoday.com/ians-blog/2016/10/17/ms-patients-pick-weeks-news-remyelination-ocrevus-mushrooms-heparin-exercise/
42. Pourmohammadi G, Moghimi H. New approach of using medicinal mushrooms for managing and curing multiple sclerosis. Fitoterapia. 2025 Sep;185:106684. doi: 10.1016/j.fitote.2025.106684. Epub 2025 Jun 15. PMID: 40527388.
https://pubmed.ncbi.nlm.nih.gov/40527388/
43. Demyelination: Demyelinating diseases and symptoms Last updated May 27, 2022, by Marisa Wexler, MS Fact-checked by Patricia Silva, PhD
https://multiplesclerosisnewstoday.com/demyelination/
44. Demyelinating disease: What can you do about it?, Eoin P. Flanagan, M.B., B.Ch.
https://www.mayoclinic.org/diseases-conditions/multiple-sclerosis/expert-answers/demyelinating-disease/faq-20058521?
45. Demyelinating Disease, Cleveland Clinic, 10/18/2023
https://my.clevelandclinic.org/health/diseases/demyelinating-disease
46. Signs & Symptoms Consistent with Demyelinating Disease, The National Multiple Sclerosis Society,
https://www.nationalmssociety.org/for-professionals/for-healthcare-professionals/diagnosing-ms/demyelinating-disease
47. Shields DC, Schaecher KE, Saido TC, Banik NL. A putative mechanism of demyelination in multiple sclerosis by a proteolytic enzyme, calpain. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11486-91. doi: 10.1073/pnas.96.20.11486. PMID: 10500203; PMCID: PMC18060.
https://www.pnas.org/doi/full/10.1073/pnas.96.20.11486
48. Aditya G. Shivane, Arundhati Chakrabarty, Multiple sclerosis and demyelination, Current Diagnostic Pathology, Volume 13, Issue 3, 2007, Pages 193-202, ISSN 0968-6053, https://doi.org/10.1016/j.cdip.2007.04.003.
49. Lubetzki C, Stankoff B. Demyelination in multiple sclerosis. Handb Clin Neurol. 2014;122:89-99. doi: 10.1016/B978-0-444-52001-2.00004-2. PMID: 24507514; PMCID: PMC7152443.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152443/
50. Zhao X, Jacob C. Mechanisms of Demyelination and Remyelination Strategies for Multiple Sclerosis. Int J Mol Sci. 2023 Mar 28;24(7):6373. doi: 10.3390/ijms24076373. PMID: 37047344; PMCID: PMC10093908.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10093908/
51. Lucchinetti CF, Popescu BF, Bunyan RF, Moll NM, Roemer SF, Lassmann H, Brück W, Parisi JE, Scheithauer BW, Giannini C, Weigand SD, Mandrekar J, Ransohoff RM. Inflammatory cortical demyelination in early multiple sclerosis. N Engl J Med. 2011 Dec 8;365(23):2188-97. doi: 10.1056/NEJMoa1100648. PMID: 22150037; PMCID: PMC3282172.
https://www.nejm.org/doi/full/10.1056/NEJMoa1100648
52. What Are Demyelinating Diseases? Medically Reviewed by Christopher Melinosky, MD on September 06, 2022 Written by Rachel Reiff Ellis, WebMD LLC
https://www.webmd.com/multiple-sclerosis/what-are-demyelinating-disorders
53. Demyelination: What Is It and Why Does It Happen?, Medically reviewed by Heidi Moawad, M.D. — Written by The Healthline Editorial Team on March 27, 2014
https://www.healthline.com/health/multiple-sclerosis/demyelination
54. What to Know About Demyelination, the Driving Force of Multiple Sclerosis, By Sara Gaynes LevyMedically reviewed by Mia Tova Minen, MD, MPH March 7, 2022
https://www.self.com/story/demyelination-and-ms
55. Haider L, Simeonidou C, Steinberger G, et al Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron, Journal of Neurology, Neurosurgery & Psychiatry 2014;85:1386-1395.
https://jnnp.bmj.com/content/85/12/1386
Ψωρίαση
1. PLoS One. 2017 Jul 18;12(7):e0181039. doi: 10.1371/journal.pone.0181039. eCollection 2017. An update on psoriasis and metabolic syndrome: A meta-analysis of observational studies. Singh S1, Young P2, Armstrong AW2.
https://www.ncbi.nlm.nih.gov/pubmed/28719618
2. J Am Acad Dermatol. 2015 Aug;73(2):242-8. doi: 10.1016/j.jaad.2015.05.001. Epub 2015 Jun 6. Prevalence of undiagnosed psoriatic arthritis among psoriasis patients: Systematic review and meta-analysis. Villani AP1, Rouzaud M2, Sevrain M3, Barnetche T4, Paul C5, Richard MA6, Beylot-Barry M2, Misery L3, Joly P7, Le Maitre M8, Aractingi S9, Aubin F10, Cantagrel A11, Ortonne JP12, Jullien D13.
https://www.ncbi.nlm.nih.gov/pubmed/26054432
3. Diabetes Metab Syndr. 2019 Mar - Apr;13(2):1405-1412. doi: 10.1016/j.dsx.2019.01.009. Epub 2019 Jan 19. The association between psoriasis and diabetes mellitus: A systematic review and meta-analysis. Mamizadeh M1, Tardeh Z2, Azami M3.
https://www.ncbi.nlm.nih.gov/pubmed/31336500
4. Am J Clin Dermatol. 2019 Feb;20(1):31-40. doi: 10.1007/s40257-018-0394-1. Association Between Psoriasis and Vitiligo: A Systematic Review and Meta-Analysis. Yen H1, Chi CC2,3.
https://www.ncbi.nlm.nih.gov/pubmed/30317450
5. Curr Opin Immunol. 2017 Dec;49:1-8. doi: 10.1016/j.coi.2017.07.007. Epub 2017 Jul 22. Psoriasis: a mixed autoimmune and autoinflammatory disease. Liang Y1, Sarkar MK1, Tsoi LC2, Gudjonsson JE3.
https://www.ncbi.nlm.nih.gov/pubmed/28738209
6. Recent Pat Inflamm Allergy Drug Discov , 8 (2), 104-17 2014 Suppression of Inflammatory and Allergic Responses by Pharmacologically Potent Fungus Ganoderma Lucidum Neha Bhardwaj, Priya Katyal, Anil K Sharma
https://pubmed.ncbi.nlm.nih.gov/24948193
7. Adv Exp Med Biol, 1181, 157-186 2019 Researches and Application of Ganoderma Spores Powder Jianhua Xu, Peng Li
https://pubmed.ncbi.nlm.nih.gov/31677143
8. Oncotarget, 9 (37), 24837-24856 2018 May 15 B-glucans From Grifola Frondosa and Ganoderma Lucidum in Breast Cancer: An Example of Complementary and Integrative Medicine Paola Rossi, Raffaele Difrancia, Vincenzo Quagliariello, Elena Savino, Paolo Tralongo, Cinzia Lucia Randazzo, Massimiliano Berretta
https://pubmed.ncbi.nlm.nih.gov/29872510
9. J Cell Mol Med, 22 (7), 3278-3297 Jul 2018 Chemical, Biochemical, Preclinical and Clinical Studies of Ganoderma Lucidum Polysaccharide as an Approved Drug for Treating Myopathy and Other Diseases in China Pengjiao Zeng, Zhihua Guo, Xuan Zeng, Cui Hao, Yiran Zhang, Meng Zhang, Yong Liu, Hui Li, Juan Li, Lijuan Zhang
https://pubmed.ncbi.nlm.nih.gov/29691994
10. Adv Exp Med Biol , 1182, 39-77 2019 Antitumor Effect of Ganoderma (Lingzhi) Mediated by Immunological Mechanism and Its Clinical Application Zhibin Lin, Lixin Sun
https://pubmed.ncbi.nlm.nih.gov/31777014
11. Integr Med (Encinitas), 13 (1), 32-44 Feb 2014 Immune Modulation From Five Major Mushrooms: Application to Integrative Oncology Alena G Guggenheim, Kirsten M Wright, Heather L Zwickey
https://pubmed.ncbi.nlm.nih.gov/26770080
12. Integr Cancer Ther, 14 (3), 249-57 May 2015 Ganoderma Lucidum for Cancer Treatment: We Are Close but Still Not There Shujie Cheng, Daniel Sliva
https://pubmed.ncbi.nlm.nih.gov/25626896
13. Tumour Biol, 37 (3), 2789-804 Mar 2016 Misconstrued Versatility of Ganoderma Lucidum: A Key Player in Multi-Targeted Cellular Signaling Balraj Singh Gill, Prateek Sharma, Raj Kumar, Sanjeev Kumar
https://pubmed.ncbi.nlm.nih.gov/26715282
14. Recent Pat Anticancer Drug Discov, 8 (3), 255-87 Sep 2013 Ganoderma Lucidum: A Potential for Biotechnological Production of Anti-Cancer and Immunomodulatory Drugs Bojana Boh
https://pubmed.ncbi.nlm.nih.gov/23227951
15. J Nanosci Nanotechnol, 5 (12), 2001-13 Dec 2005 Pharmacological and Anti-Tumor Activities of Ganoderma Spores Processed by Top-Down Approaches Xin Liu, Jiang-Hai Wang, Jian-Ping Yuan
https://pubmed.ncbi.nlm.nih.gov/16430134
16. Acta Pharmacol Sin, 25 (11), 1387-95 Nov 2004 Anti-tumor and Immunoregulatory Activities of Ganoderma Lucidum and Its Possible Mechanisms Zhi-bin Lin, Hui-na Zhang
https://pubmed.ncbi.nlm.nih.gov/15525457
17. Prog Mol Biol Transl Sci, 163, 179-219 2019 Ganoderma Lucidum Polysaccharide Used for Treating Physical Frailty in China Pengjiao Zeng, Yulong Chen, Lijuan Zhang, Maoqing Xing
https://pubmed.ncbi.nlm.nih.gov/31030748
18. Int J Biol Macromol, 121, 1160-1178 Jan 2019 Pharmacological Effects of Natural Ganoderma and Its Extracts on Neurological Diseases: A Comprehensive Review Chen Zhao, Chunchen Zhang, Zheng Xing, Zeeshan Ahmad, Jing-Song Li, Ming-Wei Chang
https://pubmed.ncbi.nlm.nih.gov/30342128
19. Curr Med Chem, 11 (11), 1423-30 Jun 2004 Immunomodulatory and Antimicrobial Effects of Some Traditional Chinese Medicinal Herbs: A Review Benny K H Tan, J Vanitha
https://pubmed.ncbi.nlm.nih.gov/15180575
20. Nutr Cancer, 53 (1), 11-7 2005 Anticancer Effects of Ganoderma Lucidum: A Review of Scientific Evidence John W M Yuen, Mayur Danny I Gohel
https://pubmed.ncbi.nlm.nih.gov/16351502
21. Front Pharmacol, 9, 1217 2018 Oct 25 eCollection 2018 Ganoderma: A Cancer Immunotherapy Review Yu Cao, Xiaowei Xu, Shujing Liu, Linfang Huang, Jian Gu
https://pubmed.ncbi.nlm.nih.gov/30410443
22. Molecules, 23 (3) 2018 Mar 13 Antitumour, Antimicrobial, Antioxidant and Antiacetylcholinesterase Effect of Ganoderma Lucidum Terpenoids and Polysaccharides: A Review Darija Cör, Željko Knez, Maša Knez Hrnčič
https://pubmed.ncbi.nlm.nih.gov/29534044
23. Biomed Pharmacother, 107, 507-519 Nov 2018 Ganoderma Lucidum: Persuasive Biologically Active Constituents and Their Health Endorsement Md Faruque Ahmad
https://pubmed.ncbi.nlm.nih.gov/30114634
24. Adv Exp Med Biol, 1182, 311-321 2019 Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Skin Diseases and Care Zhuming Yin, Baoxue Yang, Huiwen Ren
https://pubmed.ncbi.nlm.nih.gov/31777026
25. Adv Exp Med Biol, 1182, 243-262 2019 Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Renal Diseases and Clinical Applications Xiaoqiang Geng, Dandan Zhong, Limin Su, Baoxue Yang
https://pubmed.ncbi.nlm.nih.gov/31777022
26. Int J Biol Macromol, 150, 765-774 2020 Feb 6[Online ahead of print] Molecular Mechanisms of Bioactive Polysaccharides From Ganoderma Lucidum (Lingzhi), a Review Jiahui Lu, Rongjun He, Peilong Sun, Fuming Zhang, Robert J Linhardt, Anqiang Zhang
https://pubmed.ncbi.nlm.nih.gov/32035956
27. Appl Microbiol Biotechnol, 103 (23-24), 9239-9250 Dec 2019 Ganoderma Proteins and Their Potential Applications in Cosmetics Liu-Dingji Li, Pei-Wen Mao, Ke-Di Shao, Xiao-Hui Bai, Xuan-Wei Zhou
https://pubmed.ncbi.nlm.nih.gov/31659419
28. Molecules, 19 (11), 17478-535 2014 Oct 30 A Comprehensive Review of the Structure Elucidation and Biological Activity of Triterpenoids From Ganoderma Spp Qing Xia, Huazheng Zhang, Xuefei Sun, Haijuan Zhao, Lingfang Wu, Dan Zhu, Guanghui Yang, Yanyan Shao, Xiaoxue Zhang, Xin Mao, Lanzhen Zhang, Gaimei She
https://pubmed.ncbi.nlm.nih.gov/25361420
29. Adv Pharmacol, 87, 257-276 2020 Preventive and Therapeutic Effect of Ganoderma Lucidum on Kidney Injuries and Diseases Xiaoqiang Geng, Dandan Zhong, Limin Su, Zhibin Lin, Baoxue Yang
https://pubmed.ncbi.nlm.nih.gov/32089235
30. Acta Medica (Hradec Kralove), 42 (4), 123-5 1999 Anti-inflammatory Triterpenoids From Mysterious Mushroom Ganoderma Lucidum and Their Potential Possibility in Modern Medicine J Patocka
https://pubmed.ncbi.nlm.nih.gov/10812678
31. Curr Pharm Biotechnol, 10 (8), 717-42 Dec 2009 Ganoderma Lucidum: A Potent Pharmacological Macrofungus Bhagwan S Sanodiya, Gulab Singh Thakur, Rakesh K Baghel, G B K S Prasad, P S Bisen
https://pubmed.ncbi.nlm.nih.gov/19939212
32. Clin Rheumatol, 38 (10), 2659-2671 Oct 2019 Association of Total Oxidant Status, Total Antioxidant Status, and Malondialdehyde and Catalase Levels With Psoriasis: A Systematic Review and Meta-Analysis YouCan Zhang, ZhongSheng Li, Yun Ma, Zhen Mu
33. Eur J Cancer Prev, 25 (5), 462-71 Sep 2016 Ganoderma: Insights Into Anticancer Effects Nebojša V Kladar, Neda S Gavarić, Biljana N Božin
https://pubmed.ncbi.nlm.nih.gov/26317382
34. Phytochemistry, 114, 38-55 Jun 2015 Chemical Features of Ganoderma Polysaccharides With Antioxidant, Antitumor and Antimicrobial Activities Isabel C F R Ferreira, Sandrina A Heleno, Filipa S Reis, Dejan Stojkovic, Maria João R P Queiroz, M Helena Vasconcelos, Marina Sokovic
https://pubmed.ncbi.nlm.nih.gov/25457487
35. Adv Exp Med Biol, 1182, 79-118 2019 Cellular and Molecular Mechanism of Ganoderma (Lingzhi) Against Tumor Yu Sun, Lixin Sun
https://pubmed.ncbi.nlm.nih.gov/31777015
36. Appl Microbiol Biotechnol, 103 (23-24), 9239-9250 Dec 2019 Ganoderma Proteins and Their Potential Applications in Cosmetics Liu-Dingji Li, Pei-Wen Mao, Ke-Di Shao, Xiao-Hui Bai, Xuan-Wei Zhou
https://pubmed.ncbi.nlm.nih.gov/31659419
37. Adv Exp Med Biol, 1182, 181-199 2019 Protective Effect of Ganoderma (Lingzhi) on Cardiovascular System Jia Meng, Baoxue Yang
https://pubmed.ncbi.nlm.nih.gov/31777019
38. Curr Pharm Biotechnol, 10 (8), 717-42 Dec 2009 Ganoderma Lucidum: A Potent Pharmacological Macrofungus Bhagwan S Sanodiya, Gulab Singh Thakur, Rakesh K Baghel, G B K S Prasad, P S Bisen
https://pubmed.ncbi.nlm.nih.gov/19939212
39. Prog Mol Biol Transl Sci, 163, 179-219 2019 Ganoderma Lucidum Polysaccharide Used for Treating Physical Frailty in China Pengjiao Zeng, Yulong Chen, Lijuan Zhang, Maoqing Xing
https://pubmed.ncbi.nlm.nih.gov/31030748
40. Adv Pharmacol, 87, 257-276 2020 Preventive and Therapeutic Effect of Ganoderma Lucidum on Kidney Injuries and Diseases Xiaoqiang Geng, Dandan Zhong, Limin Su, Zhibin Lin, Baoxue Yang
https://pubmed.ncbi.nlm.nih.gov/32089235
41. Molecules, 19 (11), 17478-535 2014 Oct 30 A Comprehensive Review of the Structure Elucidation and Biological Activity of Triterpenoids From Ganoderma Spp Qing Xia, Huazheng Zhang, Xuefei Sun, Haijuan Zhao, Lingfang Wu, Dan Zhu, Guanghui Yang, Yanyan Shao, Xiaoxue Zhang, Xin Mao, Lanzhen Zhang, Gaimei She
https://pubmed.ncbi.nlm.nih.gov/25361420
42. Adv Exp Med Biol, 1182, 299-309 2019 Anti-aging Effect of Ganoderma (Lingzhi) With Health and Fitness Yan Pan, Zhibin Lin
https://pubmed.ncbi.nlm.nih.gov/31777025
43. Zhongguo Zhong Yao Za Zhi, 44 (5), 905-911 Mar 2019 [Pharmacokinetics of Ganoderic Acids] [Article in Chinese] Fei-Fei Zhang, Ru-Ming Liu
https://pubmed.ncbi.nlm.nih.gov/30989848
44. Cochrane Database Syst Rev. 2017 Dec 22;12:CD011535. doi: 10.1002/14651858.CD011535.pub2. Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis. Sbidian E1, Chaimani A, Garcia-Doval I, Do G, Hua C, Mazaud C, Droitcourt C, Hughes C, Ingram JR, Naldi L, Chosidow O, Le Cleach L.
https://www.ncbi.nlm.nih.gov/pubmed/29271481
45. J Am Acad Dermatol. 2017 Sep;77(3):425-440.e2. doi: 10.1016/j.jaad.2017.05.019. Psoriasis and suicidality: A systematic review and meta-analysis. Singh S1, Taylor C2, Kornmehl H3, Armstrong AW4.
https://www.ncbi.nlm.nih.gov/pubmed/28807109
46. JAMA Dermatol. 2018 Dec 1;154(12):1417-1423. doi: 10.1001/jamadermatol.2018.3631. Association of Psoriasis With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis. Fu Y1, Lee CH2, Chi CC1,3.
https://www.ncbi.nlm.nih.gov/pubmed/30422277
47. J Sex Med. 2018 Jun;15(6):839-847. doi: 10.1016/j.jsxm.2018.04.630. Epub 2018 May 4. Association Between Psoriasis and Erectile Dysfunction: A Meta-Analysis. Wu T1, Duan X2, Chen S1, Chen X1, Yu R3, Yu X4.
https://www.ncbi.nlm.nih.gov/pubmed/29735408
48. Allergy Asthma Proc. 2018 Mar 1;39(2):103-109. doi: 10.2500/aap.2018.39.4109. Association between psoriasis and asthma risk: A meta-analysis. Wang J1, Ke R, Shi W, Yan X, Wang Q, Zhang Q, Chai L, Li M.
https://www.ncbi.nlm.nih.gov/pubmed/29490768
49. Lasers Med Sci, 33 (1), 173-180 Jan 2018 A Clinical Review of Phototherapy for Psoriasis Ping Zhang, Mei X Wu
https://pubmed.ncbi.nlm.nih.gov/29067616/
http://europepmc.org/article/MED/29067616
50. J Eur Acad Dermatol Venereol, 31 (12), 1999-2009 Dec 2017 Depression and Suicidality in Psoriasis: Review of the Literature Including the Cytokine Theory of Depression J Koo, L B Marangell, M Nakamura, A Armstrong, C Jeon, T Bhutani, J J Wu
https://www.ncbi.nlm.nih.gov/pubmed/28681405
51. South Med J, 110 (2), 97-100 Feb 2017 Psoriasis and Cardiomyopathy: A Review of the Literature Taimoor Hashim, Amier Ahmad, Ayesha Chaudry, Rami Khouzam
https://www.ncbi.nlm.nih.gov/pubmed/28158878
52. Can Fam Physician, 63 (4), 278-285 Apr 2017 Diagnosis and Management of Psoriasis Whan B Kim, Dana Jerome, Jensen Yeung
https://www.ncbi.nlm.nih.gov/pubmed/28404701
http://europepmc.org/article/MED/28404701
53. Int J Mol Sci, 20 (6) 2019 Mar 23 Psoriasis Pathogenesis and Treatment Adriana Rendon, Knut Schäkel
https://www.ncbi.nlm.nih.gov/pubmed/30909615
http://europepmc.org/article/MED/30909615
54. Am Fam Physician, 87 (9), 626-33 2013 May 1 Psoriasis Nancy Weigle, Sarah McBane
https://www.ncbi.nlm.nih.gov/pubmed/23668525
55. Am J Manag Care, 22 (8 Suppl), s216-24 Jun 2016 Psoriasis and Psoriatic Arthritis Overview Alan Menter
https://www.ncbi.nlm.nih.gov/pubmed/27356193
56. Paediatr Drugs, 17 (5), 373-84 Oct 2015 Psoriasis in Children and Adolescents: Diagnosis, Management and Comorbidities I M G J Bronckers, A S Paller, M J van Geel, P C M van de Kerkhof, M M B Seyger
https://www.ncbi.nlm.nih.gov/pubmed/26072040
http://europepmc.org/article/MED/26072040
57. Lancet, 370 (9583), 263-271 2007 Jul 21 Pathogenesis and Clinical Features of Psoriasis Christopher Em Griffiths, Jonathan Nwn Barker
https://www.ncbi.nlm.nih.gov/pubmed/17658397
58. Models in the Research Process of Psoriasis. Bocheńska K, Smolińska E, Moskot M, Jakóbkiewicz-Banecka J, Gabig-Cimińska M
http://europepmc.org/article/MED/29186769
59. Front Immunol, 9, 579 2018 Apr 5 eCollection 2018 Systemic Inflammation and Cardiovascular Comorbidity in Psoriasis Patients: Causes and Consequences Wolf-Henning Boehncke
https://www.ncbi.nlm.nih.gov/pubmed/29675020
60. Ann Rheum Dis, 64 Suppl 2 (Suppl 2), ii18-23; discussion ii24-5 Mar 2005 Psoriasis: Epidemiology, Clinical Features, and Quality of Life R G B Langley, G G Krueger, C E M Griffiths
https://www.ncbi.nlm.nih.gov/pubmed/15708928
61. Int J Mol Sci, 20 (18) 2019 Sep 5 Risk Factors for the Development of Psoriasis Koji Kamiya, Megumi Kishimoto, Junichi Sugai, Mayumi Komine, Mamitaro Ohtsuki
https://www.ncbi.nlm.nih.gov/pubmed/31491865
http://europepmc.org/article/MED/31491865
62. Clin Exp Rheumatol, 33 (5 Suppl 93), S2-6 Sep-Oct 2015 Pathogenesis and Treatment of Psoriasis: Exploiting Pathophysiological Pathways for Precision Medicine Wisam Alwan, Frank O Nestle
https://www.ncbi.nlm.nih.gov/pubmed/26472336
63. Actas Dermosifiliogr, 110 (1), 12-19 Jan-Feb 2019 Psoriasis and Depression: The Role of Inflammation [Article in English, Spanish] S González-Parra, E Daudén
https://www.ncbi.nlm.nih.gov/pubmed/30509759
64. J Dermatol, 43 (1), 4-8 Jan 2016 Psoriasis: Behind the Scenes Masutaka Furue, Takafumi Kadono
https://www.ncbi.nlm.nih.gov/pubmed/26782000
65. Lakartidningen, 114 2017 Nov 21 [Psoriasis in Childhood and Adolescence] [Article in Swedish] Josefin Lysell
https://www.ncbi.nlm.nih.gov/pubmed/29292942
66. Am J Med, 131 (10), 1146-1154 Oct 2018 Psoriasis and Psoriatic Spectrum Disease: A Primer for the Primary Care Physician Jawad Bilal, Saad Ullah Malik, Irbaz Bin Riaz, Drew J B Kurtzman
https://www.ncbi.nlm.nih.gov/pubmed/29864415
67. Τher Umsch, 67 (4), 153-65 Apr 2010 [Psoriasis] [Article in German] Alexander A Navarini, Ralph M Trüeb
https://www.ncbi.nlm.nih.gov/pubmed/20336615
68. Int J Dermatol, 57 (10), 1165-1172 Oct 2018 Stress and Psoriasis Laurie Rousset, Bruno Halioua
https://www.ncbi.nlm.nih.gov/pubmed/29729012
69. J Am Acad Dermatol, 80 (5), 1332-1343 May 2019 All-cause and Cause-Specific Mortality in Psoriasis: A Systematic Review and Meta-Analysis Ashar Dhana, Hsi Yen, Hsuan Yen, Eunyoung Cho
https://pubmed.ncbi.nlm.nih.gov/30590074/
70. Indian J Dermatol Venereol Leprol, 82 (5), 489-97 Sep-Oct 2016 Psoriasis and Risk of Incident Atrial Fibrillation: A Systematic Review and Meta-Analysis Patompong Ungprasert, Narat Srivali, Wonngarm Kittanamongkolchai
https://pubmed.ncbi.nlm.nih.gov/27451924
71. Br J Dermatol, 170 (2), 304-14 Feb 2014 Psoriasis and Smoking: A Systematic Review and Meta-Analysis A W Armstrong, C T Harskamp, J S Dhillon, E J Armstrong
https://pubmed.ncbi.nlm.nih.gov/24117435
72. J Am Acad Dermatol, 71 (2), 350-8 Aug 2014 Diet and Psoriasis, Part II: Celiac Disease and Role of a Gluten-Free Diet Bhavnit K Bhatia, Jillian W Millsop, Maya Debbaneh, John Koo, Eleni Linos, Wilson Liao
https://pubmed.ncbi.nlm.nih.gov/24780176
http://europepmc.org/article/MED/24780176
73. Immunol Res, 67 (1), 134-141 Feb 2019 The Coexistence of Pemphigus and Psoriasis: A Systematic Review and Meta-Analysis Khalaf Kridin, Mouhammad Kridin, Guy Shalom, Arnon D Cohen
https://pubmed.ncbi.nlm.nih.gov/30338449
74. Australas J Dermatol, 60 (1), 23-28 Feb 2019 Association Between Bullous Pemphigoid and Psoriasis: Systematic Review and Meta-Analysis of Case-Control Studies Kevin Phan, Sourabh Goyal, Dedee F Murrell
https://pubmed.ncbi.nlm.nih.gov/30141189
75. Int Urol Nephrol, 50 (7), 1277-1283 Jul 2018 Psoriasis and Risk of Incident Chronic Kidney Disease and End-Stage Renal Disease: A Systematic Review and Meta-Analysis Patompong Ungprasert, Sukit Raksasuk
https://pubmed.ncbi.nlm.nih.gov/29644523/
76. Indian J Dermatol, 61 (2), 152-6 Mar-Apr 2016 Risk of Parkinson's Disease Among Patients With Psoriasis: A Systematic Review and Meta-analysis Patompong Ungprasert, Narat Srivali, Wonngarm Kittanamongkolchai
https://pubmed.ncbi.nlm.nih.gov/27057013
77. Zhonghua Nan Ke Xue, 23 (3), 256-261 Mar 2017 [Correlation of Psoriasis With Erectile Dysfunction: A Meta-Analysis] [Article in Chinese] Fan-Bo Zhang, Bang-Cai Wu, Li-Bo Xie, Rui Jiang
https://pubmed.ncbi.nlm.nih.gov/29706048
78. QJM, 107 (10), 793-7 Oct 2014 Psoriasis and Risk of Venous Thromboembolism: A Systematic Review and Meta-Analysis Patompong Ungprasert, Anawin Sanguankeo, Sikarin Upala, Promporn Suksaranjit
https://pubmed.ncbi.nlm.nih.gov/24713224/
79. J Dermatolog Treat, 27 (4), 316-21 Aug 2016 Association Between Psoriasis and Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis Patompong Ungprasert, Narat Srivali, Charat Thongprayoon
https://pubmed.ncbi.nlm.nih.gov/26458363
80. J Dermatolog Treat, 28 (5), 406-410 Aug 2017 Psoriasis Increases Risk of New-Onset Atrial Fibrillation: A Systematic Review and Meta-Analysis of Prospective Observational Studies Sikarin Upala, Afeefa Shahnawaz, Anawin Sanguankeo
https://pubmed.ncbi.nlm.nih.gov/27794626
81. Indian J Dermatol, 63 (3), 193-200 May-Jun 2018 Association Between Psoriasis and Helicobacter pylori Infection: A Systematic Review and Meta-analysis Wai Chung Yong, Sikarin Upala, Anawin Sanguankeo
https://pubmed.ncbi.nlm.nih.gov/29937554
82. Medicina (Kaunas), 55 (10) 2019 Sep 26 Helicobacter pylori Infection and Psoriasis: A Systematic Review and Meta-Analysis Mingyang Yu, Rongguang Zhang, Peng Ni, Shuaiyin Chen, Guangcai Duan
https://pubmed.ncbi.nlm.nih.gov/31561576
83. J Invest Dermatol, 138 (1), 38-45 Jan 2018 Efficacy of Systemic Treatments of Psoriasis on Pruritus: A Systemic Literature Review and Meta-Analysis Chloé Théréné, Emilie Brenaut, Thomas Barnetche, Laurent Misery
https://pubmed.ncbi.nlm.nih.gov/28887107
84. J Eur Acad Dermatol Venereol, 27 Suppl 3, 2-11 Aug 2013 Psoriasis, Cardiovascular Events, Cancer Risk and Alcohol Use: Evidence-Based Recommendations Based on Systematic Review and Expert Opinion M-A Richard, T Barnetche, C Horreau, E Brenaut, C Pouplard, S Aractingi, F Aubin, B Cribier, P Joly, D Jullien, M Le Maître, L Misery, J-P Ortonne, C Paul
https://pubmed.ncbi.nlm.nih.gov/23845148/
85. Australas J Dermatol, 45 (3), 155-9; quiz 160-1 Aug 2004 Psychiatric Morbidity in Psoriasis: A Review Paul A J Russo, Ralf Ilchef, Alan J Cooper
https://pubmed.ncbi.nlm.nih.gov/15250891
86. Fleming P, Kraft J, Gulliver WP, Lynde C. The Relationship of Obesity With the Severity of Psoriasis: A Systematic Review. J Cutan Med Surg. 2015 Sep-Oct;19(5):450-6. doi: 10.1177/1203475415586332. Epub 2015 May 7. PMID: 26271963.
https://pubmed.ncbi.nlm.nih.gov/26271963/
87. Budu-Aggrey A, Brumpton B, Tyrrell J, Watkins S, Modalsli EH, Celis-Morales C, Ferguson LD, Vie GÅ, Palmer T, Fritsche LG, Løset M, Nielsen JB, Zhou W, Tsoi LC, Wood AR, Jones SE, Beaumont R, Saunes M, Romundstad PR, Siebert S, McInnes IB, Elder JT, Davey Smith G, Frayling TM, Åsvold BO, Brown SJ, Sattar N, Paternoster L. Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study. PLoS Med. 2019 Jan 31;16(1):e1002739. doi: 10.1371/journal.pmed.1002739. PMID: 30703100; PMCID: PMC6354959.
https://pubmed.ncbi.nlm.nih.gov/30703100/
88. Guo Z, Yang Y, Liao Y, Shi Y, Zhang LJ. Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity. JID Innov. 2021 Oct 13;2(1):100064. doi: 10.1016/j.xjidi.2021.100064. PMID: 35024685; PMCID: PMC8659781.
https://pubmed.ncbi.nlm.nih.gov/35024685/
89. Mendes LC. Effective fuling (Poria Cocos) for the treatment of obesity? Int J Complement Alt Med. 2018;11(6):380-385. DOI: 10.15406/ijcam.2018.11.00430
https://medcraveonline.com/IJCAM/effective-fuling-poria-cocos-for-the-treatment-of-obesity.html
https://www.researchgate.net/publication/329950997_Effective_fuling_Poria_Cocos_for_the_treatment_of_obesity
90. Weng SW, Chen BC, Wang YC, Liu CK, Sun MF, Chang CM, Lin JG, Yen HR. Traditional Chinese Medicine Use among Patients with Psoriasis in Taiwan: A Nationwide Population-Based Study. Evid Based Complement Alternat Med. 2016;2016:3164105. doi: 10.1155/2016/3164105. Epub 2016 Oct 16. PMID: 27822287; PMCID: PMC5086381.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5086381/
91. Su, Y., Qin, W., Wu, L. et al. A review of Chinese medicine for the treatment of psoriasis: principles, methods and analysis. Chin Med 16, 138 (2021). https://doi.org/10.1186/s13020-021-00550-y
https://cmjournal.biomedcentral.com/articles/10.1186/s13020-021-00550-y
92. Sung YF, Yin JH, Lee KH, Tsai CL, Lin YK, Chen SY, Chung CH, Chien WC, Lee JT, Chou CH. Increased risk of sleep-related movement disorder in patients with Helicobacter pylori infection: A nationwide population-based study. Front Neurol. 2022 Oct 10;13:953821. doi: 10.3389/fneur.2022.953821. PMID: 36299273; PMCID: PMC9589275.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589275/
93. Wei BR, Zhao YJ, Cheng YF, Huang C, Zhang F. Helicobacter pylori infection and Parkinson's Disease: etiology, pathogenesis and levodopa bioavailability. Immun Ageing. 2024 Jan 2;21(1):1. doi: 10.1186/s12979-023-00404-1. PMID: 38166953; PMCID: PMC10759355.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10759355/
94. Rothenbacher D, Bode G, Peschke F, Berg G, Adler G, Brenner H. Active infection with Helicobacter pylori in an asymptomatic population of middle aged to elderly people. Epidemiol Infect. 1998 Jun;120(3):297-303. doi: 10.1017/s0950268898008644. PMID: 9692608; PMCID: PMC2809407.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809407/
95. Graham DY, Malaty HM, Evans DG, Evans DJ Jr, Klein PD, Adam E. Epidemiology of Helicobacter pylori in an asymptomatic population in the United States. Effect of age, race, and socioeconomic status. Gastroenterology. 1991 Jun;100(6):1495-501. doi: 10.1016/0016-5085(91)90644-z. PMID: 2019355.
https://pubmed.ncbi.nlm.nih.gov/2019355/
96. Epidemiology of, and risk factors for, Helicobacter pylori infection among 3194 asymptomatic subjects in 17 populations. The EUROGAST Study Group. Gut. 1993 Dec;34(12):1672-6. doi: 10.1136/gut.34.12.1672. PMID: 8282253; PMCID: PMC1374460.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1374460/
97. Oludemi Taofiq, Sandrina A. Heleno, Ricardo C. Calhelha, Maria José Alves, Lillian Barros, Ana M. González-Paramás, Maria F. Barreiro, Isabel C.F.R. Ferreira, The potential of Ganoderma lucidum extracts as bioactive ingredients in topical formulations, beyond its nutritional benefits, Food and Chemical Toxicology, Volume 108, Part A, 2017, Pages 139-147, ISSN 0278-6915, https://doi.org/10.1016/j.fct.2017.07.051.
https://www.sciencedirect.com/science/article/abs/pii/S0278691517304337
Α1. Angelini, Paola & Girometta, Carolina & Venanzoni, Roberto & Bertuzzi, Gianluigi. (2022). Anti-Aging Properties of Medicinal Mushrooms in Systemic Aesthetic Medicine. 10.1007/978-981-16-6257-7_7.
https://www.researchgate.net/publication/359317471_Anti-Aging_Properties_of_Medicinal_Mushrooms_in_Systemic_Aesthetic_Medicine
Α2. Kumar, Nanjangud & Quispe, Cristina & Herrera, Jesús & Herrera Belén, Lisandra & Loren Reyes, Pía & Salazar, Luis & Silva, Victor & Orhan, Ilkay & Senol Deniz, Fatma & Nemli, Elifsu & Capanoglu, Esra & Olatunde, Ahmed & Silva, Nathalia & Živković, Jelena & Shorog, Eman & Calina, Daniela & Sharifi-Rad, Javad. (2023). Potential of Mushrooms Bioactive for the Treatment of Skin Diseases and Disorders. Journal of Food Biochemistry. 2023. 1-26. 10.1155/2023/5915769.
https://www.researchgate.net/publication/376450794_Potential_of_Mushrooms_Bioactive_for_the_Treatment_of_Skin_Diseases_and_Disorders
Α3. Fordjour E, Manful CF, Javed R, Galagedara LW, Cuss CW, Cheema M, Thomas R. Chaga mushroom: a super-fungus with countless facets and untapped potential. Front Pharmacol. 2023 Dec 5;14:1273786. doi: 10.3389/fphar.2023.1273786. PMID: 38116085; PMCID: PMC10728660.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10728660/
Α4. Burlec, A.F.; Hăncianu, M.; Ivănescu, B.; Macovei, I.; Corciovă, A. Exploring the Therapeutic Potential of Natural Compounds in Psoriasis and Their Inclusion in Nanotechnological Systems. Antioxidants 2024, 13, 912. https://doi.org/10.3390/antiox13080912
https://www.mdpi.com/2076-3921/13/8/912
Α5. personal care, skin diseases Psoriasis – Plant-based Approach to Strengthen the Skin’s Immune System S. Hettwer, E. Besic Gyenge, B. Suter, B. Obermayer
https://www.rahn-group.com/en/rahn/download-document/845ab00f-9b60-4457-8f65-4162f5f81add/pd_literature_liftonin-qi_techpaper_sofw_2206_enp001621675.pdf
Α6. What are the benefits of lion’s mane mushrooms? Medically reviewed by Kim Rose-Francis RDN, CDCES, LD, Nutrition — Written by Jayne Leonard — Updated on December 10, 2024
https://www.medicalnewstoday.com/articles/323400
Αϋπνία
1. Karna B, Sankari A, Tatikonda G. Sleep Disorder. [Updated 2023 Jun 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK560720/
https://www.ncbi.nlm.nih.gov/books/NBK560720/
2. Jaquelini Betta Canever, Gabriela Zurman, Felipe Vogel, Daiana Vieira Sutil, Juliano Bergamaschine Mata Diz, Ana Lúcia Danielewicz, Bruno de Souza Moreira, Helena Iturvides Cimarosti, Núbia Carelli Pereira de Avelar, Worldwide prevalence of sleep problems in community-dwelling older adults: A systematic review and meta-analysis, Sleep Medicine, Volume 119, 2024, Pages 118-134, ISSN 1389-9457, https://doi.org/10.1016/j.sleep.2024.03.040.
https://www.sciencedirect.com/science/article/abs/pii/S1389945724001448
3. Amiri S, Behnezhad S. Smoking and risk of sleep-related issues: a systematic review and meta-analysis of prospective studies. Can J Public Health. 2020 Oct;111(5):775-786. doi: 10.17269/s41997-020-00308-3. Epub 2020 Mar 17. PMID: 32185746; PMCID: PMC7501367.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7501367/
4. Vernia F, Di Ruscio M, Ciccone A, Viscido A, Frieri G, Stefanelli G, Latella G. Sleep disorders related to nutrition and digestive diseases: a neglected clinical condition. Int J Med Sci. 2021 Jan 1;18(3):593-603. doi: 10.7150/ijms.45512. PMID: 33437194; PMCID: PMC7797530.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7797530/
5. Zhao M, Tuo H, Wang S, Zhao L. The Effects of Dietary Nutrition on Sleep and Sleep Disorders. Mediators Inflamm. 2020 Jun 25;2020:3142874. doi: 10.1155/2020/3142874. PMID: 32684833; PMCID: PMC7334763.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7334763/
6. Exploring the Uses of the Top Medicinal Mushrooms, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Tarikh Input: 22/02/2023 | Kemaskini: 04/04/2023 | aslamiah
https://sgs.upm.edu.my/artikel/exploring_the_uses_of_the_top_medicinal_mushrooms-71534
7. Jia L-F, Chen P, Qu G-D, et al. A comprehensive review of the sedative-hypnotic mechanisms of edible fungi. Food & Medicine Homology, 2025, https://doi.org/10.26599/FMH.2025.9420049
https://www.sciopen.com/article/10.26599/FMH.2025.9420049
8. Wei Chen, Jun-Wen Yu, Yu-Yi Deng, Lut Yi Wong, Chen Wang, Yu-Ling Liang, Yuk-Tung Leung, Jia-Yi Tian, Ying Wu, Kelvin Sze-Yin Leung, Jinhui Hu, Wen-Hua Chen, Xiaobing Dou, Xiu-Qiong Fu, Ying-Jie Chen, Zhi-Ling Yu, Identification of sedative-hypnotic compounds shared by five medicinal Polyporales mushrooms using UPLC-Q-TOF-MS/MS-based untargeted metabolomics, Phytomedicine, Volume 128, 2024, 155355, ISSN 0944-7113, https://doi.org/10.1016/j.phymed.2024.155355.
https://www.sciencedirect.com/science/article/abs/pii/S0944711324000205
9. Tselepis, George & Palamiotis, Ioannis & Georgiou, Sofia. (2023). Homeostasis of Circadian Rhythm and Therapeutic Approaches to Manage its Related-Disorders: The Case of Medicinal Mushrooms Rich in Melatonin. Med Discoveries. 2. 10.52768/2993-1142/1075.
https://www.researchgate.net/publication/375439212_Homeostasis_of_Circadian_Rhythm_and_Therapeutic_Approaches_to_Manage_its_Related-Disorders_The_Case_of_Medicinal_Mushrooms_Rich_in_Melatonin
10. Lu J, Su M, Zhou X, Li D, Niu X, Wang Y. Research Progress of Bioactive Components in Sanghuangporus spp. Molecules. 2024 Mar 7;29(6):1195. doi: 10.3390/molecules29061195. PMID: 38542832; PMCID: PMC10976032.
https://pubmed.ncbi.nlm.nih.gov/38542832/
11. Yao L, Lv J, Duan C, An X, Zhang C, Li D, Li C, Liu S. Armillaria mellea fermentation liquor ameliorates p-chlorophenylalanine-induced insomnia associated with the modulation of serotonergic system and gut microbiota in rats. J Food Biochem. 2022 Feb;46(2):e14075. doi: 10.1111/jfbc.14075. Epub 2022 Jan 5. PMID: 34984694.
https://pubmed.ncbi.nlm.nih.gov/34984694/
12. Sharma H, Sharma N, An SSA. Unique Bioactives from Zombie Fungus (Cordyceps) as Promising Multitargeted Neuroprotective Agents. Nutrients. 2023 Dec 27;16(1):102. doi: 10.3390/nu16010102. PMID: 38201932; PMCID: PMC10780653.
https://pubmed.ncbi.nlm.nih.gov/38201932/
13. Tan YF, Mo JS, Wang YK, Zhang W, Jiang YP, Xu KP, Tan GS, Liu S, Li J, Wang WX. The ethnopharmacology, phytochemistry and pharmacology of the genus Hericium. J Ethnopharmacol. 2024 Jan 30;319(Pt 3):117353. doi: 10.1016/j.jep.2023.117353. Epub 2023 Oct 29. PMID: 37907145.
https://pubmed.ncbi.nlm.nih.gov/37907145/
14. Published April 20, 2009 COMPLEMENTARY and ALTERNATIVE MEDICINE Adaptogenic or Medicinal Mushrooms M. Saljoughian, PharmD, PhD
https://www.uspharmacist.com/article/adaptogenic-or-medicinal-mushrooms
15. Yao, C., Wang, Z., Jiang, H. et al. Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice. Sci Rep 11, 13660 (2021). https://doi.org/10.1038/s41598-021-92913-6
https://www.nature.com/articles/s41598-021-92913-6
16. Batra P, Sharma AK, Khajuria R. Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. Int J Med Mushrooms. 2013;15(2):127-43. doi: 10.1615/intjmedmushr.v15.i2.20. PMID: 23557365.
https://pubmed.ncbi.nlm.nih.gov/23557365/
17. Lee KH, Morris-Natschke SL, Yang X, Huang R, Zhou T, Wu SF, Shi Q, Itokawa H. Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine. J Tradit Complement Med. 2012 Apr;2(2):84-95. PMID: 24716120; PMCID: PMC3942920.
https://core.ac.uk/download/pdf/82062841.pdf
18. Reishi Cultivation The mushroom of immortality, Michael den Herder, European Forest Institute, [email protected] April 2022
https://efi.int/sites/default/files/files/knowledge/projects/EFI_Reishi_Cultivation_EN.pdf
19. Sanodiya BS, Thakur GS, Baghel RK, Prasad GB, Bisen PS. Ganoderma lucidum: a potent pharmacological macrofungus. Curr Pharm Biotechnol. 2009 Dec;10(8):717-42. doi: 10.2174/138920109789978757. PMID: 19939212.
https://pubmed.ncbi.nlm.nih.gov/19939212/
20. Yao C, Wang Z, Jiang H, Yan R, Huang Q, Wang Y, Xie H, Zou Y, Yu Y, Lv L. Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice. Sci Rep. 2021 Jul 1;11(1):13660. doi: 10.1038/s41598-021-92913-6. PMID: 34211003; PMCID: PMC8249598.
https://pubmed.ncbi.nlm.nih.gov/34211003/
21. Xiang-Yu Cui, Su-Ying Cui, Juan Zhang, Zi-Jun Wang, Bin Yu, Zhao-Fu Sheng, Xue-Qiong Zhang, Yong-He Zhang, Extract of Ganoderma lucidum prolongs sleep time in rats, Journal of Ethnopharmacology, Volume 139, Issue 3, 2012, Pages 796-800, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2011.12.020.
https://www.sciencedirect.com/science/article/abs/pii/S0378874111008981
Α1. Mai E, Buysse DJ. Insomnia: Prevalence, Impact, Pathogenesis, Differential Diagnosis, and Evaluation. Sleep Med Clin. 2008;3(2):167-174. doi: 10.1016/j.jsmc.2008.02.001. PMID: 19122760; PMCID: PMC2504337.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504337/
Α2. Sleep Disorders, USA National Library of Medicine
https://medlineplus.gov/sleepdisorders.html
Α3. Insomnia, Department of Neurology Sleep Medicine Center, Washington University School of Medicine
https://sleep.wustl.edu/sleep-disorders-and-treatments/sleep-disorders/insomnia/
Α4. Insomnia: What You Need to Know as You Age, Rachel Salas, M.D., Johns Hopkins University
https://www.hopkinsmedicine.org/health/conditions-and-diseases/insomnia-what-you-need-to-know-as-you-age
Α5. American Psychiatric Association, What are Sleep Disorders?, Felix Torres, MD, MBA, DFAPA August 2020
https://www.psychiatry.org/patients-families/sleep-disorders/what-are-sleep-disorders
Α6. Insomnia, 15 Dec 2023, BMJ Publishing Group
https://bestpractice.bmj.com/topics/en-gb/227
Α7. Bollu PC, Kaur H. Sleep Medicine: Insomnia and Sleep. Mo Med. 2019 Jan-Feb;116(1):68-75. PMID: 30862990; PMCID: PMC6390785.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390785/
Α8. Riedel BW, Lichstein KL. Insomnia and daytime functioning. Sleep Med Rev. 2000 Jun;4(3):277-298. doi: 10.1053/smrv.1999.0074. PMID: 12531170.
https://pubmed.ncbi.nlm.nih.gov/12531170/
Α9. A Vicious Cycle: Insomnia, Anxiety, and Depression, Duke University Health System
https://www.dukehealth.org/blog/vicious-cycle-insomnia-anxiety-and-depression
Α10. Franzen PL, Buysse DJ. Sleep disturbances and depression: risk relationships for subsequent depression and therapeutic implications. Dialogues Clin Neurosci. 2008;10(4):473-81. doi: 10.31887/DCNS.2008.10.4/plfranzen. PMID: 19170404; PMCID: PMC3108260.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3108260/
Α11. Li, L., Wu, C., Gan, Y. et al. Insomnia and the risk of depression: a meta-analysis of prospective cohort studies. BMC Psychiatry 16, 375 (2016). https://doi.org/10.1186/s12888-016-1075-3
https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-016-1075-3
Α12. April 27, 2021 Lack of sleep in middle age may increase dementia risk
https://www.nih.gov/news-events/nih-research-matters/lack-sleep-middle-age-may-increase-dementia-risk
Α13. Wong R, Lovier MA. Sleep Disturbances and Dementia Risk in Older Adults: Findings From 10 Years of National U.S. Prospective Data. Am J Prev Med. 2023 Jun;64(6):781-787. doi: 10.1016/j.amepre.2023.01.008. Epub 2023 Jan 26. PMID: 36707315.
https://www.ajpmonline.org/article/S0749-3797(23)00009-0/fulltext
Α14. Hung CM, Li YC, Chen HJ, Lu K, Liang CL, Liliang PC, Tsai YD, Wang KW. Risk of dementia in patients with primary insomnia: a nationwide population-based case-control study. BMC Psychiatry. 2018 Feb 7;18(1):38. doi: 10.1186/s12888-018-1623-0. PMID: 29415688; PMCID: PMC5804010.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5804010/
Α15. Sadeghmousavi, S., Eskian, M., Rahmani, F. et al. The effect of insomnia on development of Alzheimer’s disease. J Neuroinflammation 17, 289 (2020). https://doi.org/10.1186/s12974-020-01960-9
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-020-01960-9
Α16. Osorio RS, Pirraglia E, Agüera-Ortiz LF, During EH, Sacks H, Ayappa I, Walsleben J, Mooney A, Hussain A, Glodzik L, Frangione B, Martínez-Martín P, de Leon MJ. Greater risk of Alzheimer's disease in older adults with insomnia. J Am Geriatr Soc. 2011 Mar;59(3):559-62. doi: 10.1111/j.1532-5415.2010.03288.x. PMID: 21391952; PMCID: PMC3378676.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3378676/
Α17. Lv Y-N, Cui Y, Zhang B and Huang S-M (2022) Sleep deficiency promotes Alzheimer's disease development and progression. Front. Neurol. 13:1053942. doi: 10.3389/fneur.2022.1053942
https://www.frontiersin.org/articles/10.3389/fneur.2022.1053942/full
Α18. Javaheri S, Redline S. Insomnia and Risk of Cardiovascular Disease. Chest. 2017 Aug;152(2):435-444. doi: 10.1016/j.chest.2017.01.026. Epub 2017 Jan 30. PMID: 28153671; PMCID: PMC5577359.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577359/
Α19. How Does Sleep Affect Your Heart Health?, January 4, 2021, National Center for Chronic Disease Prevention and Health Promotion , Division for Heart Disease and Stroke Prevention
https://www.cdc.gov/bloodpressure/sleep.htm
Α20. Insomnia Tied to Greater Risk of Heart Attack, Especially in Women, Nicole Napoli, American College of Cardiology Foundation
https://www.acc.org/About-ACC/Press-Releases/2023/02/23/18/23/Insomnia-Tied-to-Greater-Risk-of-Heart-Attack-Especially-in-Women
Α20. Morin CM, Altena E, Ivers H, Mérette C, LeBlanc M, Savard J, Philip P. Insomnia, hypnotic use, and road collisions: a population-based, 5-year cohort study. Sleep. 2020 Aug 12;43(8):zsaa032. doi: 10.1093/sleep/zsaa032. PMID: 32112107; PMCID: PMC7420516.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7420516/
Α21. Garbarino S, Magnavita N, Guglielmi O, Maestri M, Dini G, Bersi FM, Toletone A, Chiorri C, Durando P. Insomnia is associated with road accidents. Further evidence from a study on truck drivers. PLoS One. 2017 Oct 31;12(10):e0187256. doi: 10.1371/journal.pone.0187256. PMID: 29088276; PMCID: PMC5663450.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5663450/
Α22. Insomnia increases risk of motor vehicle deaths, other fatal injuries, Lynn Celmer, American Academy of Sleep Medicine
https://aasm.org/insomnia-increases-risk-of-motor-vehicle-deaths-other-fatal-injuries/
Α23. Léger D, Bayon V, Ohayon MM, Philip P, Ement P, Metlaine A, Chennaoui M, Faraut B. Insomnia and accidents: cross-sectional study (EQUINOX) on sleep-related home, work and car accidents in 5293 subjects with insomnia from 10 countries. J Sleep Res. 2014 Apr;23(2):143-52. doi: 10.1111/jsr.12104. Epub 2013 Nov 15. PMID: 24237855.
https://onlinelibrary.wiley.com/doi/10.1111/jsr.12104
Α24. Qiu Y, Mao ZJ, Ruan YP, Zhang X. Exploration of the anti-insomnia mechanism of Ganoderma by central-peripheral multi-level interaction network analysis. BMC Microbiol. 2021 Oct 29;21(1):296. doi: 10.1186/s12866-021-02361-5. PMID: 34715778; PMCID: PMC8555286.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555286/
Α25. Ekiz E, Oz E, Abd El-Aty AM, Proestos C, Brennan C, Zeng M, Tomasevic I, Elobeid T, Çadırcı K, Bayrak M, Oz F. Exploring the Potential Medicinal Benefits of Ganoderma lucidum: From Metabolic Disorders to Coronavirus Infections. Foods. 2023 Apr 3;12(7):1512. doi: 10.3390/foods12071512. PMID: 37048331; PMCID: PMC10094145.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10094145/
Α26. Cui X, Zhang Y. Neuropharmacological Effect and Clinical Applications of Ganoderma (Lingzhi). Adv Exp Med Biol. 2019;1182:143-157. doi: 10.1007/978-981-32-9421-9_5. PMID: 31777017.
https://pubmed.ncbi.nlm.nih.gov/31777017/
Α27. Qiu Y, Mao ZJ, Ruan YP, Zhang X. Exploration of the anti-insomnia mechanism of Ganoderma by central-peripheral multi-level interaction network analysis. BMC Microbiol. 2021 Oct 29;21(1):296. doi: 10.1186/s12866-021-02361-5. PMID: 34715778; PMCID: PMC8555286.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555286/
Α28. Evid Based Complement Alternat Med, 2019, 7861297 2019 Apr 18 eCollection 2019 Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? Luisella Vigna, Federica Morelli, Gianna M Agnelli, Filomena Napolitano, Daniela Ratto, Alessandra Occhinegro, Carmine Di Iorio, Elena Savino, Carolina Girometta, Federico Brandalise, Paola Rossi
https://europepmc.org/article/MED/31118969
Α29. Brandalise F, Roda E, Ratto D, Goppa L, Gargano ML, Cirlincione F, Priori EC, Venuti MT, Pastorelli E, Savino E, Rossi P. Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline? J Fungi (Basel). 2023 May 10;9(5):551. doi: 10.3390/jof9050551. PMID: 37233262; PMCID: PMC10218917.
https://pubmed.ncbi.nlm.nih.gov/37233262/
Α30. Okamura, Hisayoshi & Anno, Nobuko & Tsuda, Akira & Inokuchi, Takahiro & Uchimura, Naohisa & Inanaga, Kazutoyo. (2015). The effects of Hericium erinaceus (Amyloban® 3399) on sleep quality and subjective well-being among female undergraduate students: A pilot study. Personalized Medicine Universe. 4. 10.1016/j.pmu.2015.03.006.
https://www.researchgate.net/publication/276152143_The_effects_of_Hericium_erinaceus_AmylobanR_3399_on_sleep_quality_and_subjective_well-being_among_female_undergraduate_students_A_pilot_study
Α31. Wei C, Wang H, Sun X, Bai Z, Wang J, Bai G, Yao Q, Xu Y, Zhang L. Pharmacological profiles and therapeutic applications of pachymic acid (Review). Exp Ther Med. 2022 Jul 1;24(3):547. doi: 10.3892/etm.2022.11484. PMID: 35978941; PMCID: PMC9366251.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9366251/
Α32. Kim H, Choi H, Park BG, Ju HJ, Kim YI. Efficacy of Poria Cocos Extract on Sleep Quality Enhancement: A Clinical Perspective with Implications for Functional Foods. Nutrients. 2023 Oct 1;15(19):4242. doi: 10.3390/nu15194242. PMID: 37836526; PMCID: PMC10574255.
https://pubmed.ncbi.nlm.nih.gov/37836526/
A33. Hu Z, Oh S, Ha TW, Hong JT, Oh KW. Sleep-Aids Derived from Natural Products. Biomol Ther (Seoul). 2018 Jul 1;26(4):343-349. doi: 10.4062/biomolther.2018.099. PMID: 29929351; PMCID: PMC6029681.
https://pubmed.ncbi.nlm.nih.gov/29929351/
A34. Verma K, Singh D, Srivastava A. The Impact of Complementary and Alternative Medicine on Insomnia: A Systematic Review. Cureus. 2022 Aug 26;14(8):e28425. doi: 10.7759/cureus.28425. PMID: 36176875; PMCID: PMC9509538.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9509538/
A35. 12. Dr Sony Sherpa, The Benefits of Lion’s Mane Mushroom for Sleep Last Updated on March 24, 2023
https://worldmushroomsociety.com/lions-mane-sleep-benefits/
A36. Inanaga, Kazutoyo. “Amycenone, a nootropic found in Hericium erinaceum.” Personalized Medicine Universe 1 (2012): 13-17.
https://www.sciencedirect.com/science/article/abs/pii/S2186495012000089
A37. The Gift of the Night: A Six-Step Program for Better Sleep Paperback – October 3, 2023 by Philip Carr-Gomm
https://books.google.gr/books?id=BUCvEAAAQBAJ&pg=PT60&lpg=PT60&dq=lion%27s+mane+remyelination&source=bl&ots=7sEkQr0NTC&sig=ACfU3U0BuL5Cu656iOUWaEDV4ZtzgVQdhw&hl=el&sa=X&ved=2ahUKEwjK_daviJqGAxXSQPEDHWFgAKw4RhDoAXoECAcQAw#v=onepage&q=lion's%20mane%20remyelination&f=false
https://www.amazon.com/Gift-Night-Six-Step-Program-Better/dp/1644119293
https://philipcarr-gomm.com/
Τεκνοποίηση - Λίμπιντο
1. Sharma M, Leslie SW. Azoospermia. [Updated 2023 Nov 18]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK578191/
2. Cocuzza M, Alvarenga C, Pagani R. The epidemiology and etiology of azoospermia. Clinics (Sao Paulo). 2013;68 Suppl 1(Suppl 1):15-26. doi: 10.6061/clinics/2013(sup01)03. PMID: 23503951; PMCID: PMC3583160.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3583160/
3. Majzoub, A.; Viana, M.C.; Achermann, A.P.P.; Ferreira, I.T.; Laursen, R.J.; Humaidan, P.; Esteves, S.C. Non-Obstructive Azoospermia and Intracytoplasmic Sperm Injection: Unveiling the Chances of Success and Possible Consequences for Offspring. J. Clin. Med. 2024, 13, 4939. https://doi.org/10.3390/jcm13164939
https://www.mdpi.com/2077-0383/13/16/4939
4. Bundhun PK, Janoo G, Bhurtu A, Teeluck AR, Soogund MZS, Pursun M, Huang F. Tobacco smoking and semen quality in infertile males: a systematic review and meta-analysis. BMC Public Health. 2019 Jan 8;19(1):36. doi: 10.1186/s12889-018-6319-3. PMID: 30621647; PMCID: PMC6325781.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6325781/
5. Skoracka K, Eder P, Łykowska-Szuber L, Dobrowolska A, Krela-Kaźmierczak I. Diet and Nutritional Factors in Male (In)fertility-Underestimated Factors. J Clin Med. 2020 May 9;9(5):1400. doi: 10.3390/jcm9051400. PMID: 32397485; PMCID: PMC7291266.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7291266/
539. Leslie SW, Soon-Sutton TL, Khan MAB. Male Infertility. [Updated 2024 Feb 25]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK562258/
540. Huang, B., Wang, Z., Kong, Y. et al. Global, regional and national burden of male infertility in 204 countries and territories between 1990 and 2019: an analysis of global burden of disease study. BMC Public Health 23, 2195 (2023). https://doi.org/10.1186/s12889-023-16793-3
https://bmcpublichealth.biomedcentral.com/articles/10.1186/s12889-023-16793-3
541. Shah, Kirati M.; Gamit, Kanan G.; Raval, Manan A.; Vyas, Niraj Y.. Male infertility: A scoping review of prevalence, causes and treatments. Asian Pacific Journal of Reproduction 10(5):p 195-202, October 2021. | DOI: 10.4103/2305-0500.326717
https://journals.lww.com/apjr/fulltext/2021/10050/male_infertility__a_scoping_review_of_prevalence,.1.aspx
542. Agarwal A, Mulgund A, Hamada A, Chyatte MR. A unique view on male infertility around the globe. Reprod Biol Endocrinol. 2015 Apr 26;13:37. doi: 10.1186/s12958-015-0032-1. PMID: 25928197; PMCID: PMC4424520.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4424520/
543. Leslie SW, Soon-Sutton TL, Khan MAB. Male Infertility. 2024 Feb 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 32965929.
https://pubmed.ncbi.nlm.nih.gov/32965929/
544. How common is male infertility, and what are its causes? 11/18/2021, NIH Eunice Kennedy Shriver National Institute of Child Health and Human Development
https://www.nichd.nih.gov/health/topics/menshealth/conditioninfo/infertility
545. Dai JB, Wang ZX, Qiao ZD. The hazardous effects of tobacco smoking on male fertility. Asian J Androl. 2015 Nov-Dec;17(6):954-60. doi: 10.4103/1008-682X.150847. PMID: 25851659; PMCID: PMC4814952.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4814952/
546. Harlev A, Agarwal A, Gunes SO, Shetty A, du Plessis SS. Smoking and Male Infertility: An Evidence-Based Review. World J Mens Health. 2015 Dec;33(3):143-60. doi: 10.5534/wjmh.2015.33.3.143. Epub 2015 Dec 23. PMID: 26770934; PMCID: PMC4709430.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4709430/
547. Liu, Y., Chen, S., Pang, D. et al. Effects of paternal exposure to cigarette smoke on sperm DNA methylation and long-term metabolic syndrome in offspring. Epigenetics & Chromatin 15, 3 (2022). https://doi.org/10.1186/s13072-022-00437-8
https://epigeneticsandchromatin.biomedcentral.com/articles/10.1186/s13072-022-00437-8
548. Kovac JR, Labbate C, Ramasamy R, Tang D, Lipshultz LI. Effects of cigarette smoking on erectile dysfunction. Andrologia. 2015 Dec;47(10):1087-92. doi: 10.1111/and.12393. Epub 2014 Dec 29. PMID: 25557907; PMCID: PMC4485976.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4485976/
549. Skoracka K, Eder P, Łykowska-Szuber L, Dobrowolska A, Krela-Kaźmierczak I. Diet and Nutritional Factors in Male (In)fertility-Underestimated Factors. J Clin Med. 2020 May 9;9(5):1400. doi: 10.3390/jcm9051400. PMID: 32397485; PMCID: PMC7291266.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7291266/
550. Ferramosca A, Zara V. Diet and Male Fertility: The Impact of Nutrients and Antioxidants on Sperm Energetic Metabolism. Int J Mol Sci. 2022 Feb 25;23(5):2542. doi: 10.3390/ijms23052542. PMID: 35269682; PMCID: PMC8910394.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8910394/
551. Pecora, G., Sciarra, F., Gangitano, E. et al. How Food Choices Impact on Male Fertility. Curr Nutr Rep 12, 864–876 (2023). https://doi.org/10.1007/s13668-023-00503-x
https://link.springer.com/article/10.1007/s13668-023-00503-x#citeas
552. Almujaydil, M.S. The Role of Dietary Nutrients in Male Infertility: A Review. Life 2023, 13, 519. https://doi.org/10.3390/life13020519
https://www.mdpi.com/2075-1729/13/2/519
HIV
1. Lu, Da & wu, Hong & Lu, Ting-Ren. (2020). HIV/AIDS treatment, therapeutic strategy break throughs. Hospice & Palliative Medicine International Journal. 4. 10.15406/hpmij.2020.04.00182.
https://www.researchgate.net/publication/339998514_HIVAIDS_Treatment_Therapeutic_Strategy_Breakthrough
2. Olatunji OJ, Tang J, Tola A, Auberon F, Oluwaniyi O, Ouyang Z. The genus Cordyceps: An extensive review of its traditional uses, phytochemistry and pharmacology. Fitoterapia. 2018 Sep;129:293-316. doi: 10.1016/j.fitote.2018.05.010. Epub 2018 May 24. PMID: 29775778.
https://pubmed.ncbi.nlm.nih.gov/29775778/
3. Das SK, Masuda M, Sakurai A, Sakakibara M. Medicinal uses of the mushroom Cordyceps militaris: current state and prospects. Fitoterapia. 2010 Dec;81(8):961-8. doi: 10.1016/j.fitote.2010.07.010. Epub 2010 Jul 19. PMID: 20650308.
https://pubmed.ncbi.nlm.nih.gov/20650308/
4. Bhambri A, Srivastava M, Mahale VG, Mahale S, Karn SK. Mushrooms as Potential Sources of Active Metabolites and Medicines. Front Microbiol. 2022 Apr 26;13:837266. doi: 10.3389/fmicb.2022.837266. PMID: 35558110; PMCID: PMC9090473.
https://pubmed.ncbi.nlm.nih.gov/35558110/
5. Harvanová J, Maľučká LU, Uhrinová A, Vilková M, Vavra M, Pavlík M, Rajtar M, Furmaníková A. NMR and IR analysis of natural substances isolated from Cordyceps medicinal mushrooms. Ceska Slov Farm. 2018 Dec 18;67(5-6):200-204. English. PMID: 30871325.
https://pubmed.ncbi.nlm.nih.gov/30871325/
6. Ryu E, Son M, Lee M, Lee K, Cho JY, Cho S, Lee SK, Lee YM, Cho H, Sung GH, Kang H. Cordycepin is a novel chemical suppressor of Epstein-Barr virus replication. Oncoscience. 2014 Dec 18;1(12):866-881. doi: 10.18632/oncoscience.110. PMID: 25621301; PMCID: PMC4303894.
https://pubmed.ncbi.nlm.nih.gov/25621301/
7. Luo C, Xu X, Wei X, Feng W, Huang H, Liu H, Xu R, Lin J, Han L, Zhang D. Natural medicines for the treatment of fatigue: Bioactive components, pharmacology, and mechanisms. Pharmacol Res. 2019 Oct;148:104409. doi: 10.1016/j.phrs.2019.104409. Epub 2019 Aug 22. PMID: 31446039.
https://pubmed.ncbi.nlm.nih.gov/31446039/
8. Zhu Y, Ma L, Hu Q, Li J, Chen Y, Jia R, Shen S, Zeng Y. [In Vitro Anti-HIV-1 Activity of Cordyceps sinensis Extracts]. Bing Du Xue Bao. 2016 Jul;32(4):417-22. Chinese. PMID: 29979545.
https://pubmed.ncbi.nlm.nih.gov/29979545/
9. Wang SX, Liu Y, Zhang GQ, Zhao S, Xu F, Geng XL, Wang HX. Cordysobin, a novel alkaline serine protease with HIV-1 reverse transcriptase inhibitory activity from the medicinal mushroom Cordyceps sobolifera. J Biosci Bioeng. 2012 Jan;113(1):42-7. doi: 10.1016/j.jbiosc.2011.09.005. Epub 2011 Oct 20. PMID: 22014786.
https://pubmed.ncbi.nlm.nih.gov/22014786/
10. Jiang, Y.; Wong, J.H.; Fu, M.; Ng, T.B.; Liu, Z.K.; Wang, C.R.; Li, N.; Qiao, W.T.; Wen, T.Y.; Liu, F. Isolation of Adenosine, Iso-Sinensetin and Dimethylguanosine with Antioxidant and HIV-1 Protease Inhibiting Activities from Fruiting Bodies of Cordyceps militaris. Phytomedicine 2011, 18, 189–193
https://www.mdpi.com/2673-6918/2/4/32
11. Fu M, Qiao WT, Hou J (2007). Compounds from Cordyceps militaris with anti-HIV activities. Acta Scientiarum Naturalium Universitatis Nankaiensis 40:91-95.
https://journals.sagepub.com/doi/abs/10.1177/0022034511399912
12. Zhang, Yu, Guoying Zhang, and Jianya Ling. 2022. "Medicinal Fungi with Antiviral Effect" Molecules 27, no. 14: 4457. https://doi.org/10.3390/molecules27144457
https://www.mdpi.com/1420-3049/27/14/4457
13. Wong JH, Ng TB, Wang H, Sze SC, Zhang KY, Li Q, Lu X. Cordymin, an antifungal peptide from the medicinal fungus Cordyceps militaris. Phytomedicine. 2011 Mar 15;18(5):387-92. doi: 10.1016/j.phymed.2010.07.010. Epub 2010 Aug 23. PMID: 20739167.
http://higiene.unex.es/bibliogr/Antifung/Wong10P.pdf
14. Wong JH, Wang H, Ng TB. A haemagglutinin from the medicinal fungus Cordyceps militaris. Biosci Rep. 2009 Jun 25;29(5):321-7. doi: 10.1042/BSR20080153. PMID: 19093913.
https://pubmed.ncbi.nlm.nih.gov/19093913/
15. Shahrajabian MH, Sun W. The Importance of Traditional Chinese Medicine in the Intervention and Treatment of HIV while Considering its Safety and Efficacy. Curr HIV Res. 2023;21(6):331-346. doi: 10.2174/011570162X271199231128092621. PMID: 38047360.
https://pubmed.ncbi.nlm.nih.gov/38047360/
16. Lu WB, Wen RX, Guan CF. [A report on 8 seronegative converted HIV/AIDS patients with traditional Chinese medicine]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1997 May;17(5):271-3. Chinese. PMID: 9863108.
https://mednexus.org/doi/pdf/10.5555/cmj.0366-6999.108.08.p634.01
https://pubmed.ncbi.nlm.nih.gov/9863108/
17. Samarasinghe K, Y. Waisundara V. Therapeutic Properties and Anti-Lipidemic Activity of Cordyceps sinensis [Internet]. Apolipoproteins, Triglycerides and Cholesterol. IntechOpen; 2020. Available from: http://dx.doi.org/10.5772/intechopen.92616
https://www.intechopen.com/chapters/72232
18. Adotey G, Quarcoo A, Holliday JC, Fofie S, Saaka B. Effect of immunomodulating and antiviral agent of medicinal mushrooms (immune assist 24/7) on CD4+ T-lymphocyte counts of HIV-infected patients. Int J Med Mushrooms. 2011;13(2):109-13. doi: 10.1615/intjmedmushr.v13.i2.20. PMID: 22135886.
https://pubmed.ncbi.nlm.nih.gov/22135886/
https://www.researchgate.net/figure/Results-of-60-Day-Immune-Assist-24-7-Trial-with-8-HIV-Patients-Without-Antiretroviral_tbl1_51848140
19. Textbook of Natural Medicine, 4th Edition Authors : Joseph E. Pizzorno & Michael T. Murray Date of Publication: 12/2012
https://www.eu.elsevierhealth.com/textbook-of-natural-medicine-9781437723335.html?
https://books.google.gr/books?id=e_xEF3gwmmoC&pg=PA846&lpg=PA846&dq=hiv+cordyceps&source=bl&ots=J3Px7lOOxV&sig=ACfU3U0iWteLF8uaQ1xPu-Hyk8cQctC0Qg&hl=el&sa=X&ved=2ahUKEwjtn-H8_u2EAxWISfEDHZISAbY4MhDoAXoECAIQAw#v=onepage&q=hiv%20cordyceps&f=false
20. Walter Ardigò,
α. Βιογραφικό:
https://dottorardigo.it/chi-sono/curriculum/
β. Βιβλίο:
- https://www.amazon.com/Healing-Medicinal-Mushrooms-practical-handbook-ebook/dp/B07B3LL7H5
-https://books.google.gr/books?id=3hMgDgAAQBAJ&pg=PT85&lpg=PT85&dq=hiv+cordyceps&source=bl&ots=CDF4up02do&sig=ACfU3U18GrDEFEujU5IVBraAm6W3xESqqg&hl=el&sa=X&ved=2ahUKEwjtn-H8_u2EAxWISfEDHZISAbY4MhDoAXoECAQQAw#v=onepage&q=hiv%20cordyceps&f=false
21. Seetaha S, Ratanabunyong S, Tabtimmai L, Choowongkomon K, Rattanasrisomporn J, Choengpanya K. Anti-feline immunodeficiency virus reverse transcriptase properties of some medicinal and edible mushrooms. Vet World. 2020 Sep;13(9):1798-1806. doi: 10.14202/vetworld.2020.1798-1806. Epub 2020 Sep 5. PMID: 33132590; PMCID: PMC7566271.
https://pubmed.ncbi.nlm.nih.gov/33132590/
22. Forzan M, Pacini MI, Bonaccini P, Mazzei M. Antiviral effect of a commercially phytotherapeutic compound against feline immunodeficiency virus. Nat Prod Res. 2022 Aug;36(16):4159-4164. doi: 10.1080/14786419.2021.1960329. Epub 2021 Sep 29. PMID: 34586005.
https://pubmed.ncbi.nlm.nih.gov/34586005/
23. Sukati NA, Mndebele SC, Makoa ET, Ramukumba TS, Makoae LN, Seboni NM, Human S, Holzemer WL. HIV/AIDS symptom management in Southern Africa. J Pain Symptom Manage. 2005 Feb;29(2):185-92. doi: 10.1016/j.jpainsymman.2004.05.007. PMID: 15733810.
https://www.jpsmjournal.com/article/S0885-3924(04)00542-1/fulltext
24. Zhang FF, Liu RM. [Pharmacokinetics of ganoderic acids]. Zhongguo Zhong Yao Za Zhi. 2019 Mar;44(5):905-911. Chinese. doi: 10.19540/j.cnki.cjcmm.20181213.002. PMID: 30989848.
https://pubmed.ncbi.nlm.nih.gov/30989848/
25. Wu S, Zhang S, Peng B, et al. Ganoderma lucidum: a comprehensive review of phytochemistry, efficacy, safety and clinical study. Food Science and Human Wellness, 2024, 13(2): 568-596. https://doi.org/10.26599/FSHW.2022.9250051
https://www.sciopen.com/article/10.26599/FSHW.2022.9250051
26. Ahmad MF, Ahmad FA, Khan MI, Alsayegh AA, Wahab S, Alam MI, Ahmed F. Ganoderma lucidum: A potential source to surmount viral infections through β-glucans immunomodulatory and triterpenoids antiviral properties. Int J Biol Macromol. 2021 Sep 30;187:769-779. doi: 10.1016/j.ijbiomac.2021.06.122. Epub 2021 Jun 29. PMID: 34197853.
https://pubmed.ncbi.nlm.nih.gov/34197853/
27. Sanodiya BS, Thakur GS, Baghel RK, Prasad GB, Bisen PS. Ganoderma lucidum: a potent pharmacological macrofungus. Curr Pharm Biotechnol. 2009 Dec;10(8):717-42. doi: 10.2174/138920109789978757. PMID: 19939212.
https://pubmed.ncbi.nlm.nih.gov/19939212/
28. Hsu CL, Yen GC. Ganoderic Acid and Lucidenic Acid (Triterpenoid). Enzymes. 2014;36:33-56. doi: 10.1016/B978-0-12-802215-3.00003-3. PMID: 27102698.
https://pubmed.ncbi.nlm.nih.gov/27102698/
29. Tan Z, Zhao JL, Liu JM, Zhang M, Chen RD, Xie KB, Chen DW, Dai JG. Lanostane triterpenoids and ergostane-type steroids from the cultured mycelia of Ganoderma capense. J Asian Nat Prod Res. 2018 Sep;20(9):844-851. doi: 10.1080/10286020.2017.1399879. Epub 2017 Nov 9. PMID: 29119831.
https://pubmed.ncbi.nlm.nih.gov/29119831/
30. Cör Andrejč D, Knez Ž and Knez Marevci M (2022) Antioxidant, antibacterial, antitumor, antifungal, antiviral, anti-inflammatory, and nevro-protective activity of Ganoderma lucidum: An overview. Front. Pharmacol. 13:934982. doi: 10.3389/fphar.2022.934982
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.934982/full
31. Pharm Sci Asia ; 40(3), Research and Development of Ganoderma lucidum Cultivated in Thailand P. Poomsing, K. Pattanapanyasat, P. Wongsinkongman, and N. Soonthornchareonnon*
https://pharmacy.mahidol.ac.th/journal/_files/2013-40-3_01-07.pdf
32. Meng L, Bai X, Zhang S, Zhang M, Zhou S, Mukhtar I, Wang L, Li Z, Wang W. Enhanced Ganoderic Acids Accumulation and Transcriptional Responses of Biosynthetic Genes in Ganoderma lucidum Fruiting Bodies by Elicitation Supplementation. Int J Mol Sci. 2019 Jun 10;20(11):2830. doi: 10.3390/ijms20112830. PMID: 31185659; PMCID: PMC6600565.
https://pubmed.ncbi.nlm.nih.gov/31185659/
33. Tan Z, Zhao J, Liu J, Zhang M, Chen R, Xie K, Dai J. Data on eleven sesquiterpenoids from the cultured mycelia of Ganoderma capense. Data Brief. 2017 Apr 19;12:361-363. doi: 10.1016/j.dib.2017.04.012. PMID: 28491940; PMCID: PMC5413196.
https://pubmed.ncbi.nlm.nih.gov/28491940/
34. Maria S. Serna-Arbeláez, Laura Florez-Sampedro, Lina P. Orozco, Katherin Ramírez, Elkin Galeano, Wildeman Zapata, "Natural Products with Inhibitory Activity against Human Immunodeficiency Virus Type 1", Advances in Virology, vol. 2021, Article ID 5552088, 22 pages, 2021. https://doi.org/10.1155/2021/5552088
https://www.hindawi.com/journals/av/2021/5552088/
35. F. Hümeyra ZENGİNa, Nevin ŞANLIERb, .: REVIEW Connection of Ganoderma Lucidum with Health, J Tradit Complem Med. 2020;3(1):84-98 doi: 10.5336/jtracom.2019-71988
https://www.turkiyeklinikleri.com/article/en-connection-of-ganoderma-lucidum-with-health-87626.html
36. Cancemi, G.; Caserta, S.; Gangemi, S.; Pioggia, G.; Allegra, A. Exploring the Therapeutic Potential of Ganoderma lucidum in Cancer. J. Clin. Med. 2024, 13, 1153. https://doi.org/10.3390/jcm13041153
https://www.mdpi.com/2077-0383/13/4/1153
37. Luo Q, Li N and Xu J-W (2022) A methyltransferase LaeA regulates ganoderic acid biosynthesis in Ganoderma lingzhi. Front. Microbiol. 13:1025983. doi: 10.3389/fmicb.2022.1025983
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.1025983/full
38. Sanodiya S. Bhagwan, Thakur S. Gulab, Baghel K. Rakesh, Prasad B.K.S. G. and Bisen S. P., Ganoderma lucidum: A Potent Pharmacological Macrofungus, Current Pharmaceutical Biotechnology 2009; 10 (8) . https://dx.doi.org/10.2174/138920109789978757
https://www.eurekaselect.com/article/15593
39. Bharadwaj, S., Lee, K.E., Dwivedi, V.D. et al. Discovery of Ganoderma lucidum triterpenoids as potential inhibitors against Dengue virus NS2B-NS3 protease. Sci Rep 9, 19059 (2019). https://doi.org/10.1038/s41598-019-55723-5
https://www.nature.com/articles/s41598-019-55723-5
40. Herbal carbohydrates in healthcare Barbara Sawicka, ... Bernadetta Bienia, in Herbal Biomolecules in Healthcare Applications, 2022
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/lingzhi-mushroom
41. Chen, S. (2020) The Pharmacological Effects of Triterpenoids from Ganoderma lucidum and the Regulation of Its Biosynthesis. Advances in Biological Chemistry, 10, 55-65. doi: 10.4236/abc.2020.102005.
https://www.scirp.org/journal/paperinformation?paperid=99724
42. Cheng PG, Teoh TC, Rizman-Idid M. Chemical Compounds and Computational Prediction of Their Inhibitory Effects on the HIV-1 gp120 Receptor by Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), with Antler-Like Morphology of Fruiting Bodies. Int J Med Mushrooms. 2021;23(7):63-77. doi: 10.1615/IntJMedMushrooms.2021038682. PMID: 34375519.
https://pubmed.ncbi.nlm.nih.gov/34375519/
43. Wang L, Li JQ, Zhang J, Li ZM, Liu HG, Wang YZ. Traditional uses, chemical components and pharmacological activities of the genus Ganoderma P. Karst.: a review. RSC Adv. 2020 Nov 18;10(69):42084-42097. doi: 10.1039/d0ra07219b. PMID: 35516772; PMCID: PMC9057998.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9057998/
44. El Dine RS, El Halawany AM, Ma CM, Hattori M. Inhibition of the dimerization and active site of HIV-1 protease by secondary metabolites from the Vietnamese mushroom Ganoderma colossum. J Nat Prod. 2009 Nov;72(11):2019-23. doi: 10.1021/np900279u. PMID: 19813754.
https://pubmed.ncbi.nlm.nih.gov/19813754/
45. El Dine RS, El Halawany AM, Ma CM, Hattori M. Anti-HIV-1 protease activity of lanostane triterpenes from the vietnamese mushroom Ganoderma colossum. J Nat Prod. 2008 Jun;71(6):1022-6. doi: 10.1021/np8001139. Epub 2008 Jun 12. PMID: 18547117.
https://pubmed.ncbi.nlm.nih.gov/18547117/
46. Sato N, Zhang Q, Ma CM, Hattori M. Anti-human immunodeficiency virus-1 protease activity of new lanostane-type triterpenoids from Ganoderma sinense. Chem Pharm Bull (Tokyo). 2009 Oct;57(10):1076-80. doi: 10.1248/cpb.57.1076. PMID: 19801861.
https://pubmed.ncbi.nlm.nih.gov/19801861/
47. el-Mekkawy S, Meselhy MR, Nakamura N, et al. Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum. Phytochemistry. Nov 1998;49(6):1651-1657.
https://pubmed.ncbi.nlm.nih.gov/9862140/
48. Min BS, Nakamura N, Miyashiro H, et al. Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease. Chemical & pharmaceutical bulletin. Oct 1998;46(10):1607-1612.
https://pubmed.ncbi.nlm.nih.gov/9810695/
49. Kim, H.W., Shim, M.J., Choi, E.C. et al. Inhibition of cytopathic effect of human immunodeficiency virus-1 by water-soluble extract ofGanoderma lucidum . Arch. Pharm. Res. 20, 425–431 (1997). https://doi.org/10.1007/BF02973934
https://link.springer.com/article/10.1007/BF02973934
50. Kang, Devinna & Mutakin, Mutakin & Levita, Jutti. (2015). Computational Study of Triterpenoids of Ganoderma lucidum with Aspartic Protease Enzymes for Discovering HIV-1 and Plasmepsin Inhibitors. International Journal of Chemistry. 7. 62-68. 10.5539/ijc.v7n1p62.
https://pustaka.unpad.ac.id/archives/144063
51. Wang HX, Ng TB. A laccase from the medicinal mushroom Ganoderma lucidum. Appl Microbiol Biotechnol. 2006 Sep;72(3):508-13. doi: 10.1007/s00253-006-0314-9. Epub 2006 Apr 25. PMID: 16636832.
https://pubmed.ncbi.nlm.nih.gov/16636832/
52. FLÓREZ-SAMPEDRO, L., ZAPATA, W., Zapata, L. P., MEJÍA, A. I., ARBOLEDA, C., & RUGELES, M. T. (2016). In vitro anti-HIV-1 activity of the enzymatic extract enriched with laccase produced by the fungi Ganoderma sp. and Lentinus sp. Vitae, 23(2), 109–118. https://doi.org/10.17533/udea.vitae.v23n2a03
https://revistas.udea.edu.co/index.php/vitae/article/view/23524
53. Choengpanya K, Ratanabunyong S, Seetaha S, Tabtimmai L, Choowongkomon K. Anti-HIV-1 reverse transcriptase property of some edible mushrooms in Asia. Saudi J Biol Sci. 2021 May;28(5):2807-2815. doi: 10.1016/j.sjbs.2021.02.012. Epub 2021 Feb 16. PMID: 34012322; PMCID: PMC8116966.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116966/
54. Λοίμωξη με HIV Γραφική αναπαράσταση του κύκλου ζωής και αναπαραγωγής του ιού HIV
http://www.hivaids.gr/i/pliroforisi/kyklos
55. Ma B, Ren W, Zhou Y, Ma J, Ruan Y, Wen CN. Triterpenoids from the spores of Ganoderma lucidum. N Am J Med Sci. 2011 Nov;3(11):495-8. doi: 10.4297/najms.2011.3495. PMID: 22361494; PMCID: PMC3271404.
https://pubmed.ncbi.nlm.nih.gov/22361494/
56. Τζούπης Χαράλαμπος, Design of novel inhibitors for renin and HIV-1 protease, 10.12681/eadd/42598, 2014
https://phdtheses.ekt.gr/eadd/handle/10442/42598
57. Akbar R, Yam WK. Interaction of ganoderic acid on HIV related target: molecular docking studies. Bioinformation. 2011;7(8):413-7. doi: 10.6026/97320630007413. Epub 2011 Dec 21. PMID: 22347784; PMCID: PMC3280442.
https://pubmed.ncbi.nlm.nih.gov/22347784/
58. Clinical Naturopathic Medicine by Hechtman, 2nd Edition, Leah Hechtman, 2019, 9780729542425
https://www.vasiliadis-books.gr/shop/clinical-naturopathic-medicine-by-hechtman-2nd-edition/
https://books.google.gr/books?id=Z9cMOSbgozIC&pg=PA382&lpg=PA382&dq=hiv+Ganoderma&source=bl&ots=OvRicdzIlT&sig=ACfU3U2WoAvOMh-ZvCVoU0T1rb-H6cf1rA&hl=el&sa=X&ved=2ahUKEwit0YWinfGEAxUsBNsEHRiiDyY4HhDoAXoECAMQAw#v=onepage&q=hiv%20Ganoderma&f=false
59. Ganoderma Cultivation, Chemistry and Medicinal Applications, Volume 1 Edited By Krishnendu Acharya, Somanjana Khatua Copyright 2024
https://www.routledge.com/Ganoderma-Cultivation-Chemistry-and-Medicinal-Applications-Volume--1/Acharya-Khatua/p/book/9781032397610
https://books.google.gr/books?id=BbrxEAAAQBAJ&pg=PT187&lpg=PT187&dq=hiv+Ganoderma&source=bl&ots=rDecAQUmnO&sig=ACfU3U0hjGRFTkj0HuVn97DPRnuNd1pa_A&hl=el&sa=X&ved=2ahUKEwiMw_WunfGEAxWCefEDHQ8fB604KBDoAXoECAMQAw#v=onepage&q=hiv%20Ganoderma&f=false
60. Prof. Lin Zhanxi & Mdm Lin D.M. Fujian Agriculture and Forestry University (FAFU) Fujian Province JUNCAO Bio-Engineering Center, 2009
http://ls.china-embassy.gov.cn/eng/sgdt/200904/P020210828154351689068.pdf
61. Αριθμός CD4 κυττάρων, Lab Tests Online, Ελληνική Εταιρεία Κλινικής Χημείας-Κλινικής Βιοχημείας
http://www.labtestsonline.gr/tests/CD4.html?tab=6
62. Mohan, S. & Chinnaswamy, P. & S., Krishnamoorthy. (2005). A Study on the Effect of Ganoderma lucidum (W.Curt.: Fr.) Lloyd in Indian HIV Carriers. International Journal of Medicinal Mushrooms. 7. 431-432. 10.1615/IntJMedMushr.v7.i3.750.
https://www.dl.begellhouse.com/journals/708ae68d64b17c52,0d0f121956dd501b,23171b8261ba4b96.html
63. Gonkhom, Didsanutda & Luangharn, Thatsanee & Raghoonundon, Bhavesh & Hyde, Kevin & Stadler, Marc & Thongklang, Naritsada. (2021). Hericium: A review of the cultivation, health-enhancing applications, economic importance, industrial, and pharmaceutical applications. Fungal Biotec. 1. 115-127. 10.5943/FunBiotec/1/2/8.
https://www.researchgate.net/publication/357340574_Hericium_A_review_of_the_cultivation_health-enhancing_applications_economic_importance_industrial_and_pharmaceutical_applications
64. Guo-Qing Zhang, Qing-Jun Chen, Jing Hua, Zi-Lu Liu, Yue Sun, Xin Xu, Peng Han, He-Xiang Wang, "An Inulin-Specific Lectin with Anti-HIV-1 Reverse Transcriptase, Antiproliferative, and Mitogenic Activities from the Edible Mushroom Agaricus bitorquis", BioMed Research International, vol. 2019, Article ID 1341370, 9 pages, 2019. https://doi.org/10.1155/2019/1341370
https://www.hindawi.com/journals/bmri/2019/1341370/
65. Li Y, Zhang G, Ng TB, Wang H. A novel lectin with antiproliferative and HIV-1 reverse transcriptase inhibitory activities from dried fruiting bodies of the monkey head mushroom Hericium erinaceum. J Biomed Biotechnol. 2010;2010:716515. doi: 10.1155/2010/716515. Epub 2010 Jun 13. PMID: 20625408; PMCID: PMC2896861.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2896861/
66. Hassan, Mohamed & Rouf, Razina & Tiralongo, Evelin & May, Tom & Tiralongo, Joe. (2015). Mushroom Lectins: Specificity, Structure and Bioactivity Relevant to Human Disease. International Journal of Molecular Sciences. 16. 7802-7838. 10.3390/ijms16047802.
https://www.researchgate.net/figure/Anti-HIV-1-reverse-transcriptase-activity-of-mushroom-lectins_tbl10_275240899
https://www.researchgate.net/publication/275240899_Mushroom_Lectins_Specificity_Structure_and_Bioactivity_Relevant_to_Human_Disease
67. Oke MA, Afolabi FJ, Oyeleke OO, Kilani TA, Adeosun AR, Olanbiwoninu AA and Adebayo EA (2022) Ganoderma lucidum: Unutilized natural medicine and promising future solution to emerging diseases in Africa. Front. Pharmacol. 13:952027. doi: 10.3389/fphar.2022.952027
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.952027/full
68. 2nd Edition Encyclopedia of Dietary Supplements Edited By Paul M. Coates, Joseph M. Betz, Marc R. Blackman, Gordon M. Cragg, Mark Levine, Joel Moss, Jeffrey D. White
https://www.routledge.com/Encyclopedia-of-Dietary-Supplements/Coates-Betz-Blackman-Cragg-Levine-Moss-White/p/book/9781439819289
https://books.google.gr/books?id=WoW1DwAAQBAJ&pg=PA686&lpg=PA686&dq=reishi+reverse+transcriptase+ic50&source=bl&ots=oul3X8NRfw&sig=ACfU3U3P0QW3DhQ5smtG_EAxzd0RZLQNyQ&hl=el&sa=X&ved=2ahUKEwjg1tTupviEAxVQQPEDHch4DTE4FBDoAXoECAIQAw#v=onepage&q=reishi%20reverse%20transcriptase%20ic50&f=false
69. Παγκόσμια Ημέρα κατά του AIDS 01/12/2014, Υπουργείο Υγείας
https://www.moh.gov.gr/articles/news/2075-pagkosmia-hmera-kata-toy-aids
71. Zhao Y, Tian N, Wang H, Yan H. Chemically Sulfated Polysaccharides from Agaricus blazei Murill: Synthesis, Characterization and Anti-HIV Activity. Chem Biodivers. 2021 Sep;18(9):e2100338. doi: 10.1002/cbdv.202100338. Epub 2021 Aug 9. PMID: 34296822.
https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202100338
72. Sorimachi K, Nakamoto T. Alternative medicine safety: Agaricus blazei and propolis. Comb Chem High Throughput Screen. 2011 Aug;14(7):616-21. doi: 10.2174/138620711796367238. PMID: 21599627.
https://www.ingentaconnect.com/content/ben/cchts/2011/00000014/00000007/art00006?crawler=true
73. Huang K, El-Seedi HR, Xu B. Critical review on chemical compositions and health-promoting effects of mushroom <i>Agaricus blazei</i> Murill. Current Research in Food Science. 2022 ;5:2190-2203. DOI: 10.1016/j.crfs.2022.10.029. PMID: 36387602; PMCID: PMC9661389.
https://europepmc.org/article/med/36387602
74. Handema, R., Terunuma, H. and Kasolo, F. (2007). A prospective study of agaricus blazei mycelia compound administration in asymptomatic HIV-1 infected patients in Lusaka, Zambia. Medical Journal of Zambia. 34, (1)
https://library.adhl.africa/handle/123456789/11256
75. Corcorran MA, Kim N. Chronic hepatitis B and HIV coinfection. Top Antivir Med. 2023 Mar 31;31(1):14-22. PMID: 37018732; PMCID: PMC10089291.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089291/
76. Ήπαρ, Ιωάννης Κιούσης, Στέλεχος Διατροφής και Διαιτολογίας, 13/4/2022
https://www.farmakeftikamanitaria.gr/cordyceps-ipatika-ofeli.html
77. Ηπατίτιδα Β, Ιωάννης Κιούσης, Στέλεχος Διατροφής και Διαιτολογίας, 24/10/2022
https://www.farmakeftikamanitaria.gr/ganoderma-ipatitida-b.html
78. Hsu CH, Hwang KC, Chiang YH, Chou P. The mushroom Agaricus blazei Murill extract normalizes liver function in patients with chronic hepatitis B. J Altern Complement Med. 2008 Apr;14(3):299-301. doi: 10.1089/acm.2006.6344. PMID: 18370584.
https://pubmed.ncbi.nlm.nih.gov/18370584/
79. The Impact of HIV/AIDS on the Liver December 9, 2022 | By Haley Wilson, arizona liver health
https://azliver.com/blog/the-impact-of-hiv-aids-on-the-liver/
80. Sherman KE, Thomas DL. HIV and liver disease: a comprehensive update. Top Antivir Med. 2022 Oct;30(4):547-558. PMID: 36375129; PMCID: PMC9681142.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9681142/
81. HIV and Diabetes Last Reviewed: August 10, 2021, NIH Office of AIDS Research
https://hivinfo.nih.gov/understanding-hiv/fact-sheets/hiv-and-diabetes
82. Kibirige, D., Sekitoleko, I., Owarwo, N. et al. HIV infection in adult Ugandans with new-onset type 2 diabetes: exploring its influence on the anthropometric and metabolic profile. AIDS Res Ther 20, 56 (2023). https://doi.org/10.1186/s12981-023-00553-9
https://aidsrestherapy.biomedcentral.com/articles/10.1186/s12981-023-00553-9
83. Bratt G, Brännström J, Missalidis C, Nyström T (2021) Development of type 2 diabetes and insulin resistance in people with HIV infection: Prevalence, incidence and associated factors. PLoS ONE 16(6): e0254079. https://doi.org/10.1371/journal.pone.0254079
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0254079
84. Διαβήτης και κόρντισεπς,
https://www.farmakeftikamanitaria.gr/diabetes-korntiseps.html
85. Διαβήτης, Ιωάννης Κιούσης, Στέλεχος Διατροφής και Διαιτολογίας 28/1/2024
https://www.farmakeftikamanitaria.gr/ganoderma-diavhths.html
86. Hsu CH, Liao YL, Lin SC, Hwang KC, Chou P. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med. 2007 Jan-Feb;13(1):97-102. doi: 10.1089/acm.2006.6054. PMID: 17309383.
https://pubmed.ncbi.nlm.nih.gov/17309383/
87. Radovanović Spurnić A, Brmbolić B, Stojšić Z, Pekmezović T, Bukumirić Z, Korać M, Salemović D, Pešić-Pavlović I, Stevanović G, Milošević I, Jevtović D. The increasing prevalence of HIV/Helicobacter pylori co-infection over time, along with the evolution of antiretroviral therapy (ART). PeerJ. 2017 May 30;5:e3392. doi: 10.7717/peerj.3392. PMID: 28584718; PMCID: PMC5452935.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452935/
88. Nkuize M, De Wit S. Issues Related to the Treatment of H. pylori Infection in People Living with HIV and Receiving Antiretrovirals. Microorganisms. 2022 Jul 29;10(8):1541. doi: 10.3390/microorganisms10081541. PMID: 36013959; PMCID: PMC9413132.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9413132/
89. Panos GZ, Xirouchakis E, Tzias V, Charatsis G, Bliziotis IA, Doulgeroglou V, Margetis N, Falagas ME. Helicobacter pylori infection in symptomatic HIV-seropositive and -seronegative patients: a case-control study. AIDS Res Hum Retroviruses. 2007 May;23(5):709-12. doi: 10.1089/aid.2006.0174. PMID: 17530997.
https://pubmed.ncbi.nlm.nih.gov/17530997/
90. Ιωάννης Κιούσης, Στέλεχος Διατροφής και Διαιτολογίας, 7/3/2024, τι σκοτώνει το ελικοβακτηρίδιο
https://www.farmakeftikamanitaria.gr/ti-skotonei-to-elikovaktiridio.html
91. Sleep Disorders and HIV, fact sheet by John-Manuel Andriote, American Psychiatric Association, HIV Psychiatry, www.psychiatry.org/AIDS.
https://www.psychiatry.org/File%20Library/Psychiatrists/Practice/Professional-Topics/HIV-Psychiatry/FactSheet-Insomnia-2012.pdf
92. Tsai YT, Chuang TJ, Mudiyanselage SPK, Ku HC, Wu YL, Li CY, Ko NY. The impact of sleep disturbances on suicide risk among people living HIV: An eleven-year national cohort. J Affect Disord. 2024 Feb 1;346:122-132. doi: 10.1016/j.jad.2023.10.045. Epub 2023 Oct 25. PMID: 37890538.
https://pubmed.ncbi.nlm.nih.gov/37890538/
93. Dabaghzadeh F, Khalili H, Ghaeli P, Alimadadi A. Sleep Quality and Its Correlates in HIV Positive Patients Who Are Candidates for Initiation of Antiretroviral Therapy. Iran J Psychiatry. 2013 Oct;8(4):160-4. PMID: 25628708; PMCID: PMC4281649.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281649/
94. Αϋπνια Φυσική Αντιμετώπιση, Ιωάννης Κιούσης, Στέλεχος Διατροφής και Διαιτολογίας 31/12/2023
https://www.farmakeftikamanitaria.gr/aypnia-fysiki-antimetopisi.html
95. HIV and AIDS and Mental Health, National Institute of Mental Health, November 2023
https://www.nimh.nih.gov/health/topics/hiv-aids
96. Tran BX, Ho RCM, Ho CSH, Latkin CA, Phan HT, Ha GH, Vu GT, Ying J, Zhang MWB. Depression among Patients with HIV/AIDS: Research Development and Effective Interventions (GAPRESEARCH). Int J Environ Res Public Health. 2019 May 19;16(10):1772. doi: 10.3390/ijerph16101772. PMID: 31109139; PMCID: PMC6571985.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571985/
97. Mudra Rakshasa-Loots, A., Whalley, H.C., Vera, J.H. et al. Neuroinflammation in HIV-associated depression: evidence and future perspectives. Mol Psychiatry 27, 3619–3632 (2022). https://doi.org/10.1038/s41380-022-01619-2
https://www.nature.com/articles/s41380-022-01619-2
98. Evid Based Complement Alternat Med, 2019, 7861297 2019 Apr 18 eCollection 2019 Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? Luisella Vigna, Federica Morelli, Gianna M Agnelli, Filomena Napolitano, Daniela Ratto, Alessandra Occhinegro, Carmine Di Iorio, Elena Savino, Carolina Girometta, Federico Brandalise, Paola Rossi
https://pubmed.ncbi.nlm.nih.gov/31118969
99. Biomed Res, 31 (4), 231-7 Aug 2010 Reduction of Depression and Anxiety by 4 Weeks Hericium Erinaceus Intake Mayumi Nagano, Kuniyoshi Shimizu, Ryuichiro Kondo, Chickako Hayashi, Daigo Sato, Katsuyuki Kitagawa, Koichiro Ohnuki
https://pubmed.ncbi.nlm.nih.gov/20834180
100. Das G, Shin HS, Leyva-Gómez G, Prado-Audelo MLD, Cortes H, Singh YD, Panda MK, Mishra AP, Nigam M, Saklani S, Chaturi PK, Martorell M, Cruz-Martins N, Sharma V, Garg N, Sharma R, Patra JK. Cordyceps spp.: A Review on Its Immune-Stimulatory and Other Biological Potentials. Front Pharmacol. 2021 Feb 8;11:602364. doi: 10.3389/fphar.2020.602364. PMID: 33628175; PMCID: PMC7898063.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898063/
101. Yadav, Ramniwas. “Entomopathogenic Mushroom (Cordyceps sp.) as Immunity Booster.” (2020).
https://www.semanticscholar.org/paper/Entomopathogenic-Mushroom-%28Cordyceps-sp.%29-as-Yadav/76fee5978329a900848ac706a02887b36650109e
102. Jung, SJ., Jung, ES., Choi, EK. et al. Immunomodulatory effects of a mycelium extract of Cordyceps (Paecilomyces hepiali; CBG-CS-2): a randomized and double-blind clinical trial. BMC Complement Altern Med 19, 77 (2019). https://doi.org/10.1186/s12906-019-2483-y
https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/s12906-019-2483-y
103. Wang C, Wang J, Qi Y. Adjuvant treatment with Cordyceps sinensis for lung cancer: A systematic review and meta-analysis of randomized controlled trials. J Ethnopharmacol. 2024 Mar 12;327:118044. doi: 10.1016/j.jep.2024.118044. Epub ahead of print. PMID: 3848495
https://pubmed.ncbi.nlm.nih.gov/38484953/
104. Gong HY, Wang KQ, Tang SG. [Effects of cordyceps sinensis on T lymphocyte subsets and hepatofibrosis in patients with chronic hepatitis B]. Hunan Yi Ke Da Xue Xue Bao. 2000 Jun 28;25(3):248-50. Chinese. PMID: 12212155.
https://pubmed.ncbi.nlm.nih.gov/12212155/
105. Zhu JL, Liu C. [Modulating effects of extractum semen Persicae and cultivated Cordyceps hyphae on immuno-dysfunction of inpatients with posthepatitic cirrhosis]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1992 Apr;12(4):207-9, 195. Chinese. PMID: 1498539.
https://pubmed.ncbi.nlm.nih.gov/1498539/
106. 徐佳吟、陳俊良、楊賢鴻（2011）。Effect of Cultured Mycelia Cordyceps Sinensis on Neutrophil and T- Cell- Mediated Immune Response in Humans。中醫藥雜誌，22(3&4)，161-172 https://doi.org/10.6940/JCM.201112_22(3_4).04
https://www.airitilibrary.com/Article/Detail/10176446-201112-201201050032-201201050032-38-49
107.Wachtel-Galor S, Tomlinson B, Benzie IF. Ganoderma lucidum ("Lingzhi"), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study. Br J Nutr. 2004 Feb;91(2):263-9. doi: 10.1079/BJN20041039. PMID: 14756912.
https://pubmed.ncbi.nlm.nih.gov/14756912/
108. Reishi Mushroom Purported Benefits, Side Effects & More, Memorial Sloan Kettering Cancer Center, February 9, 2023
https://www.mskcc.org/cancer-care/integrative-medicine/herbs/reishi-mushroom
109. Ekiz, Elif, Emel Oz, A. M. Abd El-Aty, Charalampos Proestos, Charles Brennan, Maomao Zeng, Igor Tomasevic, Tahra Elobeid, Kenan Çadırcı, Muharrem Bayrak, and et al. 2023. "Exploring the Potential Medicinal Benefits of Ganoderma lucidum: From Metabolic Disorders to Coronavirus Infections" Foods 12, no. 7: 1512. https://doi.org/10.3390/foods12071512
https://www.mdpi.com/2304-8158/12/7/1512
110. Gao Y, Zhou S, Jiang W, Huang M, Dai X. Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Immunol Invest. 2003 Aug;32(3):201-15. doi: 10.1081/imm-120022979. PMID: 12916709.
https://pubmed.ncbi.nlm.nih.gov/12916709/
111. Sun LX, Li WD, Lin ZB, Duan XS, Li XF, Yang N, Lan TF, Li M, Sun Y, Yu M, Lu J. Protection against lung cancer patient plasma-induced lymphocyte suppression by Ganoderma lucidum polysaccharides. Cell Physiol Biochem. 2014;33(2):289-99. doi: 10.1159/000356669. Epub 2014 Jan 31. PMID: 24525691.
https://pubmed.ncbi.nlm.nih.gov/24525691/
112. Jin X, Ruiz Beguerie J, Sze DM, Chan GC. Ganoderma lucidum (Reishi mushroom) for cancer treatment. Cochrane Database Syst Rev. 2016 Apr 5;4(4):CD007731. doi: 10.1002/14651858.CD007731.pub3. PMID: 27045603; PMCID: PMC6353236.
https://pubmed.ncbi.nlm.nih.gov/27045603/
113. Duque Henao, Sandra & Urrego, Sergio & Cano, Andrea & Higuita, Edwin. (2018). Randomized Clinical Trial for the Evaluation of Immune Modulation by Yogurt Enriched with β-Glucans from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Children from Medellin, Colombia. International Journal of Medicinal Mushrooms. 20. 705.
https://www.researchgate.net/publication/328676151_Randomized_Clinical_Trial_for_the_Evaluation_of_Immune_Modulation_by_Yogurt_Enriched_with_b-Glucans_from_Lingzhi_or_Reishi_Medicinal_Mushroom_Ganoderma_lucidum_Agaricomycetes_in_Children_from_Medellin
114. Chen, Shiu-Nan, Fan-Hua Nan, Ming-Wei Liu, Min-Feng Yang, Ya-Chih Chang, and Sherwin Chen. 2023. "Evaluation of Immune Modulation by β-1,3; 1,6 D-Glucan Derived from Ganoderma lucidum in Healthy Adult Volunteers, A Randomized Controlled Trial" Foods 12, no. 3: 659. https://doi.org/10.3390/foods12030659
https://www.mdpi.com/2304-8158/12/3/659
115. Zhong L, Yan P, Lam WC, Yao L, Bian Z. Coriolus Versicolor and Ganoderma Lucidum Related Natural Products as an Adjunct Therapy for Cancers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front Pharmacol. 2019 Jul 3;10:703. doi: 10.3389/fphar.2019.00703. PMID: 31333449; PMCID: PMC6616310.
https://pubmed.ncbi.nlm.nih.gov/31333449/
116. Zhang S, Pang G, Chen C, Qin J, Yu H, Liu Y, Zhang X, Song Z, Zhao J, Wang F, Wang Y, Zhang LW. Effective cancer immunotherapy by Ganoderma lucidum polysaccharide-gold nanocomposites through dendritic cell activation and memory T cell response. Carbohydr Polym. 2019 Feb 1;205:192-202. doi: 10.1016/j.carbpol.2018.10.028. Epub 2018 Oct 13. PMID: 30446095.
https://pubmed.ncbi.nlm.nih.gov/30446095/
117. Αθλητική Απόδοση, Αντοχή και Διάρκεια Ιωάννης Κιούσης, Στέλεχος Διατροφής και Διαιτολογίας. Τελευταία ενημέρωση: 10/1/2024
https://www.farmakeftikamanitaria.gr/cordyceps-athlitikes-epidoseis.html
118. Jakopovich I. New dietary supplements from medicinal mushrooms: Dr Myko San--a registration report. Int J Med Mushrooms. 2011;13(3):307-13. doi: 10.1615/intjmedmushr.v13.i3.110. PMID: 22135883.
https://pubmed.ncbi.nlm.nih.gov/22135883/
Διαβήτης
1.Diabetes, Cleveland Clinic, 02/17/2023
https://my.clevelandclinic.org/health/diseases/7104-diabetes
2.Hossain MJ, Al-Mamun M, Islam MR. Diabetes mellitus, the fastest growing global public health concern: Early detection should be focused. Health Sci Rep. 2024 Mar 22;7(3):e2004. doi: 10.1002/hsr2.2004. PMID: 38524769; PMCID: PMC10958528.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10958528/
3.Chapter 3Global picture, IDF DIABETES ATLAS [Internet]. 10th edition.
https://www.ncbi.nlm.nih.gov/books/NBK581940/
4.Prof. Dr. Taj Jamshaid. Diabetes Mellitus – The Epidemic of 21 Century. Esculapio - JSIMS [Internet]. 2023 May 13 [cited 2025 Nov. 23];19(01):1-2. Available from: https://esculapio.pk/journal/index.php/journal-files/article/view/272
https://esculapio.pk/journal/index.php/journal-files/article/view/272
5.Konstantinos Makrilakis, Natasa Kalpourtzi, Ioannis Ioannidis, Stella Iraklianou, Athanasios Raptis, Alexis Sotiropoulos, Magda Gavana, Apostolos Vantarakis, Maria Kantzanou, Christos Hadjichristodoulou, Grigoris Chlouverakis, Grigoris Trypsianis, Paraskevi V. Voulgari, Yannis Alamanos, Giota Touloumi, Stavros Liatis, Prevalence of diabetes and pre-diabetes in Greece. Results of the First National Survey of Morbidity and Risk Factors (EMENO) study, Diabetes Research and Clinical Practice, Volume 172, 2021, 108646, ISSN 0168-8227, https://doi.org/10.1016/j.diabres.2020.108646.
https://www.sciencedirect.com/science/article/abs/pii/S0168822720309037
6.Diabetes mellitus, LEFKOS STAVROS
https://lefkosstavros.gr/en/diabetes-mellitus/
7.Type 2 diabetes, Feb. 27, 2025, Mayo Foundation for Medical Education and Research
https://www.mayoclinic.org/diseases-conditions/type-2-diabetes/symptoms-causes/syc-20351193
8.Type 2 Diabetes, Last Reviewed May 2017, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK),
https://www.niddk.nih.gov/health-information/diabetes/overview/what-is-diabetes/type-2-diabetes
9. Type 1 diabetes medicine, 08 June 2023, British Diabetic Association
https://www.diabetes.org.uk/about-diabetes/type-1-diabetes/treatments/medicine
10. Insulin and type 2 diabetes, British Diabetic Association
https://www.diabetes.org.uk/about-diabetes/looking-after-diabetes/treatments/insulin/type-2-diabetes
11.Dahlén AD, Dashi G, Maslov I, Attwood MM, Jonsson J, Trukhan V, Schiöth HB. Trends in Antidiabetic Drug Discovery: FDA Approved Drugs, New Drugs in Clinical Trials and Global Sales. Front Pharmacol. 2022 Jan 19;12:807548. doi: 10.3389/fphar.2021.807548. PMID: 35126141; PMCID: PMC8807560.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8807560/
12.Usai R, Majoni S and Rwere F (2022) Natural products for the treatment and management of diabetes mellitus in Zimbabwe-a review. Front. Pharmacol. 13:980819. doi: 10.3389/fphar.2022.980819
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.980819/full
13. Weinberg Sibony, R.; Segev, O.; Dor, S.; Raz, I. Drug Therapies for Diabetes. Int. J. Mol. Sci. 2023, 24, 17147. https://doi.org/10.3390/ijms242417147
https://www.mdpi.com/1422-0067/24/24/17147
14. Are Antidiabetic Drugs Safe in the Long Term? Global Forum, V. Mohan Diabetes Specialities Centre and Madras Diabetes Research Foundation
https://globalforum.diaglobal.org/issue/march-2021/are-antidiabetic-drugs-safe-in-the-long-term/
15. Weinberg Sibony, R.; Segev, O.; Dor, S.; Raz, I. Drug Therapies for Diabetes. Int. J. Mol. Sci. 2023, 24, 17147. https://doi.org/10.3390/ijms242417147
https://www.mdpi.com/1422-0067/24/24/17147
16. Gulam, Shabaz & Palaian, Subish & Shankar, P Ravi & Sam, Kishore & Kumar, Mukesh. (2019). UNCOMMON SIDE EFFECTS OF COMMONLY USED ANTI-DIABETICS: TIME TO MONITOR THEM. International Journal of Pharmaceutical Sciences and Research. 10. 4145.
https://www.researchgate.net/publication/340077756_UNCOMMON_SIDE_EFFECTS_OF_COMMONLY_USED_ANTI-DIABETICS_TIME_TO_MONITOR_THEM
17. Oral & Injectable Medications for Type 2 Diabetes, American Diabetes Association,
https://diabetes.org/health-wellness/medication/oral-other-injectable-diabetes-medications
18. Chandrasekaran, P.; Weiskirchen, R. The Role of Obesity in Type 2 Diabetes Mellitus—An Overview. Int. J. Mol. Sci. 2024, 25, 1882. https://doi.org/10.3390/ijms25031882
https://www.mdpi.com/1422-0067/25/3/1882
19.Asgari S, Masrouri S, Khalili D, Lotfaliany M, Hadaegh F. Weight Gain, Weight Loss, and Type 2 Diabetes Risk: Evidence From the Atherosclerosis Risk in Communities (ARIC) Study. Endocrinol Diabetes Metab. 2025 May;8(3):e70040. doi: 10.1002/edm2.70040. PMID: 40198876; PMCID: PMC11978231.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11978231/
20.Yedjou CG, Grigsby J, Mbemi A, Nelson D, Mildort B, Latinwo L, Tchounwou PB. The Management of Diabetes Mellitus Using Medicinal Plants and Vitamins. Int J Mol Sci. 2023 May 22;24(10):9085. doi: 10.3390/ijms24109085. PMID: 37240430; PMCID: PMC10218826.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10218826/
21.Usai R, Majoni S, Rwere F. Natural products for the treatment and management of diabetes mellitus in Zimbabwe-a review. Front Pharmacol. 2022 Aug 24;13:980819. doi: 10.3389/fphar.2022.980819. PMID: 36091798; PMCID: PMC9449367.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9449367/
22.Sknepnek A, Miletić D, Stupar A, Salević-Jelić A, Nedović V and Cvetanović Kljakić A (2025) Natural solutions for diabetes: the therapeutic potential of plants and mushrooms. Front. Nutr. 12:1511049. doi: 10.3389/fnut.2025.1511049
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1511049/full
23.Shamim MZ, Mishra AK, Kausar T, Mahanta S, Sarma B, Kumar V, Mishra PK, Panda J, Baek KH, Mohanta YK. Exploring Edible Mushrooms for Diabetes: Unveiling Their Role in Prevention and Treatment. Molecules. 2023 Mar 21;28(6):2837. doi: 10.3390/molecules28062837. PMID: 36985818; PMCID: PMC10058372.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10058372/
24. Németh, Z.; Paulinné Bukovics, M.; Sümegi, L.D.; Sturm, G.; Takács, I.; Simon-Szabó, L. The Importance of Edible Medicinal Mushrooms and Their Potential Use as Therapeutic Agents Against Insulin Resistance. Int. J. Mol. Sci. 2025, 26, 827. https://doi.org/10.3390/ijms26020827
https://www.mdpi.com/1422-0067/26/2/827
25. Mohammad Azizur Rahman and Rabeya Akter, (2022). Diabetes Ameliorating Effect of Mushrooms. J. Diabetes and Islet Biology, 5(1); DOI:10.31579/2641-8975/026
https://www.auctoresonline.org/article/diabetes-ameliorating-effect-of-mushrooms-and-ameliorating-diabetes
26.Rubiya Khursheed, Sachin Kumar Singh, Sheetu Wadhwa, Monica Gulati, Ankit Awasthi, Therapeutic potential of mushrooms in diabetes mellitus: Role of polysaccharides, International Journal of Biological Macromolecules, Volume 164, 2020, Pages 1194-1205, ISSN 0141-8130, https://doi.org/10.1016/j.ijbiomac.2020.07.145.
https://www.sciencedirect.com/science/article/abs/pii/S0141813020339088
27. HURIEZ C. Indications actuelles de la mycothérapie [Current indications of mycotherapy]. Paris Med. 1945 Nov 30;35:374-80. French. PMID: 21021559.
https://pubmed.ncbi.nlm.nih.gov/21021559/
28. DIOT. Premiers essais de mycothérapie dans les affections pyogènes et leurs résultats [First trials of mycotherapy in pyogenic conditions and their results]. Maroc Med. 1946 Feb-Mar;25(258):10-2. French. PMID: 20993868.
https://pubmed.ncbi.nlm.nih.gov/20993868/
29. CHABROL E. La mycothérapie dans les cirrhoses du foie [Mycotherapy in liver cirrhosis]. Presse Therm Clim. 1949 Jan-Feb;86(1-2):1-5. French. PMID: 18115812.
https://pubmed.ncbi.nlm.nih.gov/18115812/
30. KOURILSKY R. La mycothérapie dans la tuberculose pulmonaire chronique [Mycotherapy in chronic pulmonary tuberculosis]. Laval Med. 1949 Dec;14(10):1319-40. French. PMID: 15408327.
https://pubmed.ncbi.nlm.nih.gov/15408327/
31. Medicinal Mushrooms (PDQ®)–Patient Version, July 11, 2024, National Cancer Institute at the National Institutes of Health https://www.cancer.gov/about-cancer/treatment/cam/patient/mushrooms-pdq
32. Alaa A.M. Osman, Adrienn Seres-Bokor, Eszter Ducza, Diabetes mellitus therapy in the light of oxidative stress and cardiovascular complications, Journal of Diabetes and its Complications, Volume 39, Issue 2, 2025, 108941, ISSN 1056-8727, https://doi.org/10.1016/j.jdiacomp.2024.108941.
https://www.sciencedirect.com/science/article/pii/S1056872724002678
33. Caturano A, D'Angelo M, Mormone A, Russo V, Mollica MP, Salvatore T, Galiero R, Rinaldi L, Vetrano E, Marfella R, Monda M, Giordano A, Sasso FC. Oxidative Stress in Type 2 Diabetes: Impacts from Pathogenesis to Lifestyle Modifications. Curr Issues Mol Biol. 2023 Aug 12;45(8):6651-6666. doi: 10.3390/cimb45080420. PMID: 37623239; PMCID: PMC10453126.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10453126/
34. Asmat U, Abad K, Ismail K. Diabetes mellitus and oxidative stress-A concise review. Saudi Pharm J. 2016 Sep;24(5):547-553. doi: 10.1016/j.jsps.2015.03.013. Epub 2015 Mar 21. PMID: 27752226; PMCID: PMC5059829.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5059829/
35. Yueting Cai, Shuiqing Hu, Jingrui Liu, Jinlan Luo, Wenhua Li, Jiaxin Tang, Siyang Liu, Ruolan Dong, Yan Yang, Ling Tu, Xizhen Xu, Diabetic vascular calcification inhibited by soluble epoxide hydrolase gene deletion via regressing NID2-mediated IGF2-ERK1/2 signaling pathway, Chinese Medical Journal, 10.1097/CM9.0000000000003792, 138, 20, (2657-2668), (2025).
https://mednexus.org/doi/10.1097/CM9.0000000000003230
36. An, Y., Xu, Bt., Wan, Sr. et al. The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction. Cardiovasc Diabetol 22, 237 (2023). https://doi.org/10.1186/s12933-023-01965-7
https://cardiab.biomedcentral.com/articles/10.1186/s12933-023-01965-7
37.Giacco F, Brownlee M. Oxidative stress and diabetic complications. Circ Res. 2010 Oct 29;107(9):1058-70. doi: 10.1161/CIRCRESAHA.110.223545. PMID: 21030723; PMCID: PMC2996922.
https://www.ahajournals.org/doi/10.1161/circresaha.110.223545
38.Mwangi RW, Macharia JM, Wagara IN, Bence RL. The antioxidant potential of different edible and medicinal mushrooms. Biomed Pharmacother. 2022 Mar;147:112621. doi: 10.1016/j.biopha.2022.112621. Epub 2022 Jan 10. PMID: 35026489.
https://www.sciencedirect.com/science/article/pii/S0753332222000099
39. Podkowa, A., Kryczyk-Poprawa, A., Opoka, W. et al. Culinary–medicinal mushrooms: a review of organic compounds and bioelements with antioxidant activity. Eur Food Res Technol 247, 513–533 (2021). https://doi.org/10.1007/s00217-020-03646-1
https://link.springer.com/article/10.1007/s00217-020-03646-1
40. Aramabašić Jovanović J, Mihailović M, Uskoković A, Grdović N, Dinić S, Vidaković M. The Effects of Major Mushroom Bioactive Compounds on Mechanisms That Control Blood Glucose Level. J Fungi (Basel). 2021 Jan 16;7(1):58. doi: 10.3390/jof7010058. PMID: 33467194; PMCID: PMC7830770.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7830770/
41.Altaf S, Asmara, Iftikhar A and Muzaffar H, 2025. Pharmacological importance of medicinal mushroom Ganoderma specie for the treatment of diabetes. In: Khan A, Hussain R, Tahir S and Ghafoor N (eds), Medicinal Plants and Aromatics: A Holistic Health Perspective. Unique Scientific Publishers, Faisalabad, Pakistan, pp: 9-14. https://doi.org/10.47278/book.HH/2025.423
https://uniquescientificpublishers.com/pdf-files/HH/Medicinal-Plants-and-Aromatics/9-14.pdf
42. Aramabašić Jovanović, J.; Mihailović, M.; Uskoković, A.; Grdović, N.; Dinić, S.; Vidaković, M. The Effects of Major Mushroom Bioactive Compounds on Mechanisms That Control Blood Glucose Level. J. Fungi 2021, 7, 58. https://doi.org/10.3390/jof7010058
https://www.mdpi.com/2309-608X/7/1/58
43. Randeni, N., J. Luo, and B. Xu. 2025. “ Unveiling the Molecular Mechanisms of Natural Triterpenoids From Mushrooms Against Type 2 Diabetes: A Critical Review.” Phytotherapy Research 39, no. 8: 3466–3485. https://doi.org/10.1002/ptr.70030.
https://onlinelibrary.wiley.com/doi/10.1002/ptr.70030?af=R
44.Yingnan Jiang, Hongning Song, Guoying Zhang, Jianya Ling, The application of medicinal fungi from the subphylum Ascomycota in the treatment of type 2 diabetes, Journal of Future Foods, Volume 5, Issue 4, 2025, Pages 361-371, ISSN 2772-5669, https://doi.org/10.1016/j.jfutfo.2024.07.014.
https://www.sciencedirect.com/science/article/pii/S277256692400048X
45. Wu, Tong & Xu, Baojun. (2015). Antidiabetic and Antioxidant Activities of Eight Medicinal Mushroom Species from China. International journal of medicinal mushrooms. 17. 129-40. 10.1615/IntJMedMushrooms.v17.i2.40.
https://www.researchgate.net/publication/273326880_Antidiabetic_and_Antioxidant_Activities_of_Eight_Medicinal_Mushroom_Species_from_China
46. Alvandi, H., Ansari, E. ., Kianirad, S. ., Hatamian-Zarmi, A., Mokhtari Hosseini, Z. B., & Ebrahimi-Hosseinzadeh, B. (2022). Medicinal mushrooms as potential therapeutic agents in the treatment of diabetes mellitus: a review with focusing on in vivo and clinical studies. Italian Journal of Mycology, 51(1), 75–96. https://doi.org/10.6092/issn.2531-7342/15023
https://italianmycology.unibo.it/article/view/15023
47.De Silva, D.D., Rapior, S., Hyde, K.D. et al. Medicinal mushrooms in prevention and control of diabetes mellitus. Fungal Diversity 56, 1–29 (2012). https://doi.org/10.1007/s13225-012-0187-4
https://link.springer.com/article/10.1007/s13225-012-0187-4
48. Medicinal mushrooms show promise for combating insulin resistance February 25, 2025 By Angelika Erdélyi Semmelweis University
https://semmelweis.hu/english/2025/02/medicinal-mushrooms-show-promise-for-combating-insulin-resistance/
49. Ebru Deveci, Fatih Çayan, Gülsen Tel-Çayan, Mehmet Emin Duru, Inhibitory activities of medicinal mushrooms on α-amylase and α-glucosidase-enzymes related to type 2 diabetes, South African Journal of Botany, Volume 137, 2021, Pages 19-23, ISSN 0254-6299, https://doi.org/10.1016/j.sajb.2020.09.039.
https://www.sciencedirect.com/science/article/pii/S025462992031111X
50. Rašeta M, Popović M, Čapo I, Stilinović N, Vukmirović S, Milošević B, Karaman M. Antidiabetic effect of two different Ganoderma species tested in alloxan diabetic rats. RSC Adv. 2020 Mar 11;10(17):10382-10393. doi: 10.1039/c9ra10158f. PMID: 35498606; PMCID: PMC9050389.
https://pubs.rsc.org/en/content/articlehtml/2020/ra/c9ra10158f
51. Holmes, D. Medicinal mushroom reduces obesity by modulating microbiota. Nat Rev Endocrinol 11, 504 (2015). https://doi.org/10.1038/nrendo.2015.114
https://www.nature.com/articles/nrendo.2015.114
52. Al-Goblan AS, Al-Alfi MA, Khan MZ. Mechanism linking diabetes mellitus and obesity. Diabetes Metab Syndr Obes. 2014 Dec 4;7:587-91. doi: 10.2147/DMSO.S67400. PMID: 25506234; PMCID: PMC4259868.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259868/
53. Gao, Yihuai & Lan, Jin & Dai, Xihu & Ye, Jingxian & Zhou, Shufeng. (2004). A Phase I/II Study of Ling Zhi Mushroom Ganoderma lucidum (W.Curt.:Fr.)Lloyd (Aphyllophoromycetideae) Extract in Patients with Type II Diabetes Mellitus. International Journal of Medicinal Mushrooms - INT J MED MUSHROOMS. 6. 33-40. 10.1615/IntJMedMushr.v6.i1.30.
https://www.researchgate.net/publication/247855021_A_Phase_III_Study_of_Ling_Zhi_Mushroom_Ganoderma_lucidum_WCurtFrLloyd_Aphyllophoromycetideae_Extract_in_Patients_with_Type_II_Diabetes_Mellitus
Α1. Tropical Journal of Pharmaceutical Research December 2023; 22 (12): 2561-2566 ISSN: 1596-5996 (print); 1596-9827 (electronic) © Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, 300001 Nigeria, view Article Hypoglycemic and glucose-lowering properties of Cordyceps militaris Phuong Dong Tran Nguyen1, Nguyen Binh Truong2, Thuan Duc Lao1
https://www.ajol.info/index.php/tjpr/article/view/262293
Α2. Huang, T., Zhou, Y., Lu, X., Tang, C., Ren, C., Bao, X., Deng, Z., Cao, X., Zou, J., Zhang, Q., & Ma, B. (2022). Cordycepin, a major bioactive component of Cordyceps militaris, ameliorates diabetes-induced testicular damage through the Sirt1/Foxo3a pathway. Andrologia, 54, e14294. https://doi.org/10.1111/and.14294
https://onlinelibrary.wiley.com/doi/pdf/10.1111/and.14294
Α3. Zhang J, Yang Z, Zhao Z and Zhang N (2024) Structural and pharmacological insights into cordycepin for neoplasms and metabolic disorders. Front. Pharmacol. 15:1367820. doi: 10.3389/fphar.2024.1367820
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1367820/full
Α4. Huizhen Sun, Anyong Zhang, Yanchun Gong, Wei Sun, Baiyi Yan, Shuihong Lei, Li-Hua Yao, Improving effect of cordycepin on insulin synthesis and secretion in normal and oxidative-damaged INS-1 cells, European Journal of Pharmacology, Volume 920, 2022, 174843, ISSN 0014-2999, https://doi.org/10.1016/j.ejphar.2022.174843.
https://www.sciencedirect.com/science/article/abs/pii/S0014299922001042
Α5. Baiyi Yan, Yanchun Gong, Wei Meng, Huizhen Sun, Wenxi Li, Kaizhi Ding, Caixia Dang, Xiaofei Gao, Wei Sun, Chunhua Yuan, Songhua Wang, Li-Hua Yao, Cordycepin protects islet β-cells against glucotoxicity and lipotoxicity via modulating related proteins of ROS/JNK signaling pathway, Biomedicine & Pharmacotherapy, Volume 163, 2023, 114776, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2023.114776.
https://www.sciencedirect.com/science/article/pii/S0753332223005656
Α6. Zheng, R., Zhang, W., Song, J. et al. Cordycepin from Cordyceps militaris ameliorates diabetic nephropathy via the miR-193b-5p/MCL-1 axis. Chin Med 18, 134 (2023). https://doi.org/10.1186/s13020-023-00842-5
https://cmjournal.biomedcentral.com/articles/10.1186/s13020-023-00842-5
Α7. Liu X, Dun M, Jian T, Sun Y, Wang M, Zhang G, Ling J. Cordyceps militaris extracts and cordycepin ameliorate type 2 diabetes mellitus by modulating the gut microbiota and metabolites. Front Pharmacol. 2023 Mar 9;14:1134429. doi: 10.3389/fphar.2023.1134429. PMID: 36969858; PMCID: PMC10033974.
https://pubmed.ncbi.nlm.nih.gov/36969858/
Α8. Cordyceps controls blood sugar levels, Bangkok,
https://www.bangkokhospital.com/en/content/cordyceps-with-diabetes
Α9. The scientific rediscovery of a precious ancient Chinese herbal regimen: Cordyceps sinensis: part II. Zhu JS1, Halpern GM, Jones K., J Altern Complement Med. 1998 Winter;4(4):429-57.
Α10. Medicinal Mushrooms, A Clinical Guide by Martin Powell,
http://mycotherapyonline.com/carous/cordyceps/
Α11. Hsu CH, Liao YL, Lin SC, Hwang KC, Chou P. The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial. J Altern Complement Med. 2007 Jan-Feb;13(1):97-102. doi: 10.1089/acm.2006.6054. PMID: 17309383.
https://pubmed.ncbi.nlm.nih.gov/17309383/
Γ51. Hsu PC, Tsai YT, Lai JN, Wu CT, Lin SK, Huang CY. Integrating traditional Chinese medicine healthcare into diabetes care by reducing the risk of developing kidney failure among type 2 diabetic patients: a population-based case control study. J Ethnopharmacol. 2014 Oct 28;156:358-64. doi: 10.1016/j.jep.2014.08.029. Epub 2014 Aug 29. PMID: 25178949.
https://pubmed.ncbi.nlm.nih.gov/25178949/
Γ52. Lee WC, Wu CC, Chuang YC, Tain YL, Chiang PH. Ba-Wei-Die-Huang-Wan (Hachimi-jio-gan) can ameliorate cyclophosphamide-induced ongoing bladder overactivity and acidic adenosine triphosphate solution-induced hyperactivity on rats prestimulated bladder. J Ethnopharmacol. 2016 May 26;184:1-9. doi: 10.1016/j.jep.2015.12.026. Epub 2015 Dec 21. PMID: 26719284.
https://pubmed.ncbi.nlm.nih.gov/26719284/
Γ54. Zhao J, Li Y, Xin L, Sun M, Yu C, Shi G, Bao T, Liu J, Ni Y, Lu R, Wu Y, Fang Z. Clinical Features and Rules of Chinese Herbal Medicine in Diabetic Peripheral Neuropathy Patients. Evid Based Complement Alternat Med. 2020 Jul 17;2020:5795264. doi: 10.1155/2020/5795264. PMID: 32724325; PMCID: PMC7382735.
https://pubmed.ncbi.nlm.nih.gov/32724325/
Γ55. Nie A, Chao Y, Zhang X, Jia W, Zhou Z, Zhu C. Phytochemistry and Pharmacological Activities of Wolfiporia cocos (F.A. Wolf) Ryvarden & Gilb. Front Pharmacol. 2020 Sep 15;11:505249. doi: 10.3389/fphar.2020.505249. PMID: 33071776; PMCID: PMC7533546.
https://pubmed.ncbi.nlm.nih.gov/33071776/
Γ56. Liu JP, Zhang M, Wang W, Grimsgaard S. Chinese herbal medicines for type 2 diabetes mellitus. Cochrane Database of Systematic Reviews 2002, Issue 3. Art. No.: CD003642. DOI: 10.1002/14651858.CD003642.pub2. Accessed 28 April 2022.
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD003642.pub2/appendices
Γ58. Xia J, Zhang L, Zhang X, Wang L, Yang B, Chen Q, Zhong M, Tang X, Zhou J. Effect of large dosage of Fuling on urinary protein of diabetic nephropathy: A protocol of systematic review and meta-analysis of randomized clinical trials. Medicine (Baltimore). 2020 Oct 2;99(40):e22377. doi: 10.1097/MD.0000000000022377. PMID: 33019413; PMCID: PMC7535777.
https://pubmed.ncbi.nlm.nih.gov/33019413/
Δυσκοιλιότητα
423. Constipation, The Johns Hopkins University
https://www.hopkinsmedicine.org/health/conditions-and-diseases/constipation
424. Complications of Constipation, Stanford Health
https://stanfordhealthcare.org/medical-conditions/primary-care/constipation/complications.html
425. Sundbøll J, Szépligeti SK, Adelborg K, et al Constipation and risk of cardiovascular diseases: a Danish population-based matched cohort study BMJ Open 2020;10:e037080. doi: 10.1136/bmjopen-2020-037080
https://bmjopen.bmj.com/content/10/9/e037080
426. PRESS RELEASE Constipation Associated with Cognitive Aging and Decline Plus, Gut Bacteria Linked to Alzheimer’s Biomarkers, Dementia Risk, Alzheimer’s Association
https://aaic.alz.org/releases_2023/constipation-gut-health-alzheimers-dementia-risk.asp
427. Constipation and faecal impaction, Alzheimer Scotland
https://www.alzscot.org/our-work/dementia-support/information-sheets/constipation-and-faecal-impaction
428. Incontinence and constipation, Alzheimers New Zealand
https://alzheimers.org.nz/get-support/supporting-someone-with-dementia/incontinence-and-constipation/
429. Chen CL, Liang TM, Chen HH, Lee YY, Chuang YC, Chen NC. Constipation and Its Associated Factors among Patients with Dementia. Int J Environ Res Public Health. 2020 Dec 3;17(23):9006. doi: 10.3390/ijerph17239006. PMID: 33287267; PMCID: PMC7730313.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7730313/
430. Editorial| Volume 4, ISSUE 11, P811, November 2019, The cost of constipation The Lancet Gastroenterology & Hepatology Published:November, 2019DOI:https://doi.org/10.1016/S2468-1253(19)30297-3
https://www.thelancet.com/journals/langas/article/PIIS2468-1253(19)30297-3/fulltext
431. Bellini, M.; Tonarelli, S.; Barracca, F.; Rettura, F.; Pancetti, A.; Ceccarelli, L.; Ricchiuti, A.; Costa, F.; de Bortoli, N.; Marchi, S.; et al. Chronic Constipation: Is a Nutritional Approach Reasonable? Nutrients 2021, 13, 3386. https://doi.org/10.3390/nu13103386
https://www.mdpi.com/2072-6643/13/10/3386
766. Wang R, Sun H, Yang T, Xu J. Causal relationship between hypertension and risk of constipation: A 2-way 2-sample Mendelian randomization study. Medicine (Baltimore). 2024 May 3;103(18):e38057. doi: 10.1097/MD.0000000000038057. PMID: 38701266; PMCID: PMC11062663.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11062663/
767. Wang, Junwen, Ye, Yuyang, Chen, Xuefeng, Hu, Xinru, Peng, Yong, Constipation and Cardiovascular Mortality Risk in Patients With Hypertension: A Long-Term Cohort Study, International Journal of Hypertension, 2025, 9921027, 9 pages, 2025. https://doi.org/10.1155/ijhy/9921027
https://onlinelibrary.wiley.com/doi/10.1155/ijhy/9921027
768. Sumida K, Molnar MZ, Potukuchi PK, Thomas F, Lu JL, Yamagata K, Kalantar-Zadeh K, Kovesdy CP. Constipation and risk of death and cardiovascular events. Atherosclerosis. 2019 Feb;281:114-120. doi: 10.1016/j.atherosclerosis.2018.12.021. Epub 2018 Dec 23. PMID: 30658186; PMCID: PMC6399019.https://pmc.ncbi.nlm.nih.gov/articles/PMC6399019/
769. Liu B, Wu X, Wang Y, Hu X. Association between constipation and risk of cardiovascular or all-cause mortality: a meta-analysis. Ann Med. 2025 Dec;57(1):2561803. doi: 10.1080/07853890.2025.2561803. Epub 2025 Sep 22. PMID: 40982729; PMCID: PMC12456042.
https://pubmed.ncbi.nlm.nih.gov/40982729/
Πάρκινσον
1. Yadav SK, Ir R, Jeewon R, Doble M, Hyde KD, Kaliappan I, Jeyaraman R, Reddi RN, Krishnan J, Li M, Durairajan SSK. A Mechanistic Review on Medicinal Mushrooms-Derived Bioactive Compounds: Potential Mycotherapy Candidates for Alleviating Neurological Disorders. Planta Med. 2020 Nov;86(16):1161-1175. doi: 10.1055/a-1177-4834. Epub 2020 Jul 14. PMID: 32663897.
https://pubmed.ncbi.nlm.nih.gov/32663897/
2. Quan Y, Ma A, Yang B. Preventive and Therapeutic Effect of Ganoderma (Lingzhi) on Brain Injury. Adv Exp Med Biol. 2019;1182:159-180. doi: 10.1007/978-981-32-9421-9_6. PMID: 31777018.
https://pubmed.ncbi.nlm.nih.gov/31777018/
3. Chen LW, Wang YQ, Wei LC, Shi M, Chan YS. Chinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinson's disease. CNS Neurol Disord Drug Targets. 2007 Aug;6(4):273-81. doi: 10.2174/187152707781387288. PMID: 17691984.
https://pubmed.ncbi.nlm.nih.gov/17691984/
4. Vo, T. S. & Vo, Tran Thi Bich Chau & Vo, Tran Thi Thu Ngoc. (2021). Available Chemical Constituents and Activities of Ganoderma Lucidum (Lingzhi or Red Reishi) Utilizing in Disease Treatment: A mini review. Journal of Research in Clinical Medicine. 9. 10.34172/jrcm.2021.032.
https://jrcm.tbzmed.ac.ir/Article/jrcm-31996
5. Ren ZL, Wang CD, Wang T, et al. Ganoderma lucidum extract ameliorates MPTP-induced parkinsonism and protects dopaminergic neurons from oxidative stress via regulating mitochondrial function, autophagy, and apoptosis. Acta Pharmacologica Sinica. 2019 Apr;40(4):441-450. DOI: 10.1038/s41401-018-0077-8. PMID: 29991712; PMCID: PMC6461997.
https://europepmc.org/article/MED/29991712
6. Poewe W, Seppi K, Tanner CM, et al. Parkinson disease. Nature reviews. Disease Primers. 2017 Mar;3:17013. DOI: 10.1038/nrdp.2017.13. PMID: 28332488.
http://europepmc.org/article/MED/28332488
7. Simon DK, Tanner CM, Brundin P. Parkinson Disease Epidemiology, Pathology, Genetics, and Pathophysiology. Clinics in Geriatric Medicine. 2020 Feb;36(1):1-12. DOI: 10.1016/j.cger.2019.08.002. PMID: 31733690; PMCID: PMC6905381.
https://europepmc.org/article/PMC/6905381
8. Kuypers KPC. Self-Medication with <i>Ganoderma lucidum</i> ("Reishi") to Combat Parkinson's Disease Symptoms: A Single Case Study. Journal of Medicinal Food. 2021 Jul;24(7):766-773. DOI: 10.1089/jmf.2020.0137. PMID: 33170078; PMCID: PMC8311956.
https://europepmc.org/article/MED/33170078
9. Qin Z, Zhang L, Sun F, Liu H, Fang X, Chan P; Chinese Parkinson Study Group. Depressive symptoms impacting on health-related quality of life in early Parkinson's disease: results from Chinese L-dopa exposed cohort. Clin Neurol Neurosurg. 2009 Nov;111(9):733-7. doi: 10.1016/j.clineuro.2009.07.001. Epub 2009 Aug 8. PMID: 19665835.
https://pubmed.ncbi.nlm.nih.gov/19665835/
10. Hemmerle AM, Herman JP, Seroogy KB. Stress, depression and Parkinson's disease. Experimental Neurology. 2012 Jan;233(1):79-86. DOI: 10.1016/j.expneurol.2011.09.035. PMID: 22001159; PMCID: PMC3268878.
https://europepmc.org/article/PMC/3268878
11. Phan CW, David P, Naidu M, Wong KH, Sabaratnam V. Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism. Crit Rev Biotechnol. 2015;35(3):355-68. doi: 10.3109/07388551.2014.887649. PMID: 24654802.
https://pubmed.ncbi.nlm.nih.gov/24654802/
12. Guo SS, Cui XL, Rausch WD. Ganoderma Lucidum polysaccharides protect against MPP(+) and rotenone-induced apoptosis in primary dopaminergic cell cultures through inhibiting oxidative stress. American Journal of Neurodegenerative Disease. 2016 ;5(2):131-144. PMID: 27335703; PMCID: PMC4913221.
https://europepmc.org/article/MED/27335703
13. Zhang R, Xu S, Cai Y, et al. Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation. Evidence-based Complementary and Alternative Medicine : Ecam. 2011 ;2011:156810. DOI: 10.1093/ecam/nep075. PMID: 19617199; PMCID: PMC3136196.
https://europepmc.org/article/MED/19617199
14. Gill BS, Kumar S, Navgeet. Ganoderic acid targeting nuclear factor erythroid 2-related factor 2 in lung cancer. Tumour Biol. 2017 Mar;39(3):1010428317695530. doi: 10.1177/1010428317695530. PMID: 28349780.
https://pubmed.ncbi.nlm.nih.gov/28349780/
15. Ganji F, Barari A, Abdi A. Effects of Ganoderma Extraction and Eight-Week Endurance Exercises on Plasma Values Neurotrophic Factors Based on Brain and Nerve Growth in Men with Parkinson's. RJMS 2021; 27 (12) :120-130
https://rjms.iums.ac.ir/article-1-6505-en.html
16. Zhang R, Xu S, Cai Y, et al. Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation. Evidence-based Complementary and Alternative Medicine : Ecam. 2011 ;2011:156810. DOI: 10.1093/ecam/nep075. PMID: 19617199; PMCID: PMC3136196.
https://europepmc.org/article/MED/19617199
17. Zhang R, Xu S, Cai Y, et al. Ganoderma lucidum Protects Dopaminergic Neuron Degeneration through Inhibition of Microglial Activation. Evidence-based Complementary and Alternative Medicine : Ecam. 2011 ;2011:156810. DOI: 10.1093/ecam/nep075. PMID: 19617199; PMCID: PMC3136196.
https://pubmed.ncbi.nlm.nih.gov/21170502/
18. McFarthing K, Rafaloff G, Baptista M, et al. Parkinson's Disease Drug Therapies in the Clinical Trial Pipeline: 2022 Update. Journal of Parkinson's Disease. 2022 ;12(4):1073-1082. DOI: 10.3233/jpd-229002. PMID: 35527571; PMCID: PMC9198738.
https://europepmc.org/article/pmc/pmc9198738
19. Effects of Lingzhi on Disease Progression in Patients With Untreated Early Parkinson's Disease, ClinicalTrials.gov.
https://clinicaltrials.gov/ct2/show/record/NCT03594656?view=record
20. Sung YF, Yin JH, Lee KH, Tsai CL, Lin YK, Chen SY, Chung CH, Chien WC, Lee JT, Chou CH. Increased risk of sleep-related movement disorder in patients with Helicobacter pylori infection: A nationwide population-based study. Front Neurol. 2022 Oct 10;13:953821. doi: 10.3389/fneur.2022.953821. PMID: 36299273; PMCID: PMC9589275.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9589275/
21. Wei BR, Zhao YJ, Cheng YF, Huang C, Zhang F. Helicobacter pylori infection and Parkinson's Disease: etiology, pathogenesis and levodopa bioavailability. Immun Ageing. 2024 Jan 2;21(1):1. doi: 10.1186/s12979-023-00404-1. PMID: 38166953; PMCID: PMC10759355.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10759355/
22. Rothenbacher D, Bode G, Peschke F, Berg G, Adler G, Brenner H. Active infection with Helicobacter pylori in an asymptomatic population of middle aged to elderly people. Epidemiol Infect. 1998 Jun;120(3):297-303. doi: 10.1017/s0950268898008644. PMID: 9692608; PMCID: PMC2809407.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2809407/
23. Graham DY, Malaty HM, Evans DG, Evans DJ Jr, Klein PD, Adam E. Epidemiology of Helicobacter pylori in an asymptomatic population in the United States. Effect of age, race, and socioeconomic status. Gastroenterology. 1991 Jun;100(6):1495-501. doi: 10.1016/0016-5085(91)90644-z. PMID: 2019355.
https://pubmed.ncbi.nlm.nih.gov/2019355/
24. Epidemiology of, and risk factors for, Helicobacter pylori infection among 3194 asymptomatic subjects in 17 populations. The EUROGAST Study Group. Gut. 1993 Dec;34(12):1672-6. doi: 10.1136/gut.34.12.1672. PMID: 8282253; PMCID: PMC1374460.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1374460/
Ε1. International Journal of Medicinal Mushrooms Volume 17, 2015 Issue 11 Lion's Mane, Hericium erinaceus and Tiger Milk, Lignosus rhinocerotis (Higher Basidiomycetes) Medicinal Mushrooms Stimulate Neurite Outgrowth in Dissociated Cells of Brain, Spinal Cord, and Retina: An In Vitro Study
https://www.dl.begellhouse.com/journals/708ae68d64b17c52,343363596ed9bda8,45484d446fc46878.html
Ε2. I-Chen Li, Li-Ya Lee, Tsai-Teng Tzeng, Wan-Ping Chen, Yen-Po Chen, Young-Ju Shiao, Chin-Chu Chen, "Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines", Behavioural Neurology, vol. 2018, Article ID 5802634, 10 pages, 2018. https://doi.org/10.1155/2018/5802634
https://www.hindawi.com/journals/bn/2018/5802634/
Ε3. Kuo, HC., Lu, CC., Shen, CH. et al. RETRACTED ARTICLE: Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade. J Transl Med 14, 78 (2016). https://doi.org/10.1186/s12967-016-0831-y
https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0831-y
Ε4. Biology, cultivation, and medicinal functions of the mushroom Hericium erinaceum Sławomir Sokół, Iwona Golak-Siwulska, Krzysztof Sobieralski, Marek Siwulski, Katarzyna Górka
https://pbsociety.org.pl/journals/index.php/am/article/view/am.1069
Ε5. He X, Wang X, Fang J, Chang Y, Ning N, Guo H, Huang L, Huang X, Zhao Z. Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion's Mane) mushroom: A review. Int J Biol Macromol. 2017 Apr;97:228-237. doi: 10.1016/j.ijbiomac.2017.01.040. Epub 2017 Jan 10. PMID: 28087447.
https://pubmed.ncbi.nlm.nih.gov/28087447/
Ε6. Cheng JH, Tsai CL, Lien YY, Lee MS, Sheu SC. High molecular weight of polysaccharides from Hericium erinaceus against amyloid beta-induced neurotoxicity. BMC Complementary and Alternative Medicine. 2016 Jun;16:170. DOI: 10.1186/s12906-016-1154-5. PMID: 27266872; PMCID: PMC4895996.
https://europepmc.org/article/MED/27266872
Ε7. Yang, Pao-Pao & CY, Lin & TY, Lin & WC, Chiang. (2020). Hericium erinaceus Mycelium Exerts Neuroprotective Effect in Parkinson’s Disease-in vitro and in vivo Models. Journal of Drug Research and Development. 6. 10.16966/2470-1009.150.
https://www.researchgate.net/publication/342205958_Hericium_erinaceus_Mycelium_Exerts_Neuroprotective_Effect_in_Parkinson%27s_Disease-in_vitro_and_in_vivo_Models
Ε8. Brandalise F, Roda E, Ratto D, Goppa L, Gargano ML, Cirlincione F, Priori EC, Venuti MT, Pastorelli E, Savino E, et al. Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline? Journal of Fungi. 2023; 9(5):551. https://doi.org/10.3390/jof9050551
https://www.mdpi.com/2309-608X/9/5/551
Ε9. Huang, HT., Ho, CH., Sung, HY. et al. Hericium erinaceus mycelium and its small bioactive compounds promote oligodendrocyte maturation with an increase in myelin basic protein. Sci Rep 11, 6551 (2021). https://doi.org/10.1038/s41598-021-85972-2
https://www.nature.com/articles/s41598-021-85972-2
Ε10. The Effect of Hericium Erinaceus Mycelium in Non-motor Symptoms of Parkinson's Disease ClinicalTrials.gov ID NCT04428983 Sponsor National Cheng-Kung University Hospital Information provided by Yuan-Ting Sun, National Cheng-Kung University Hospital (Responsible Party) Last Update Posted 2020-06-11
https://clinicaltrials.gov/study/NCT04428983
Ε11. Li IC, Chang HH, Lin CH, Chen WP, Lu TH, Lee LY, Chen YW, Chen YP, Chen CC, Lin DP. Prevention of Early Alzheimer's Disease by Erinacine A-Enriched Hericium erinaceus Mycelia Pilot Double-Blind Placebo-Controlled Study. Front Aging Neurosci. 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PMID: 32581767; PMCID: PMC7283924.
https://www.frontiersin.org/articles/10.3389/fnagi.2020.00155/full
Ε12. Biologically Functional Compounds From Mushroom-Forming Fungi Hirokazu Kawagishi, in Natural Products and Drug Discovery, 2018
https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/hericium-erinaceus
224. Sachchida Nand Rai, Divya Mishra, Payal Singh, Emanuel Vamanu, M.P. Singh, Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases, Biomedicine & Pharmacotherapy, Volume 137, 2021, 111377, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2021.111377.
https://www.sciencedirect.com/science/article/pii/S0753332221001621
225. Phan CW, David P, Naidu M, Wong KH, Sabaratnam V. Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism. Crit Rev Biotechnol. 2015;35(3):355-68. doi: 10.3109/07388551.2014.887649. PMID: 24654802.
https://pubmed.ncbi.nlm.nih.gov/24654802/
Γαστροοισοφαγική παλινδρόμηση
671. Azer SA, Hashmi MF, Reddivari AKR. Gastroesophageal Reflux Disease (GERD) [Updated 2024 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK554462/
672. Shaqran TM, Ismaeel MM, Alnuaman AA, Al Ahmad FA, Albalawi GA, Almubarak JN, AlHarbi RS, Alaqidi RS, AlAli YA, Alfawaz KS, Daghriri AA. Epidemiology, Causes, and Management of Gastro-esophageal Reflux Disease: A Systematic Review. Cureus. 2023 Oct 21;15(10):e47420. doi: 10.7759/cureus.47420. PMID: 38022211; PMCID: PMC10658748.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10658748/
673. Nirwan, J.S., Hasan, S.S., Babar, ZUD. et al. Global Prevalence and Risk Factors of Gastro-oesophageal Reflux Disease (GORD): Systematic Review with Meta-analysis. Sci Rep 10, 5814 (2020). https://doi.org/10.1038/s41598-020-62795-1
https://www.nature.com/articles/s41598-020-62795-1
674. Baklola, M., Terra, M., Badr, A. et al. Prevalence of gastro-oesophageal reflux disease, and its associated risk factors among medical students: a nation-based cross-sectional study. BMC Gastroenterol 23, 269 (2023). https://doi.org/10.1186/s12876-023-02899-w
https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-023-02899-w
675. Zhang D, Liu S, Li Z, Wang R. Global, regional and national burden of gastroesophageal reflux disease, 1990-2019: update from the GBD 2019 study. Ann Med. 2022 Dec;54(1):1372-1384. doi: 10.1080/07853890.2022.2074535. PMID: 35579516; PMCID: PMC9122392.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9122392/
676. Eivind Ness-Jensen, Jesper Lagergren, Tobacco smoking, alcohol consumption and gastro-oesophageal reflux disease, Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 5, 2017, Pages 501-508, ISSN 1521-6918, https://doi.org/10.1016/j.bpg.2017.09.004.
https://www.sciencedirect.com/science/article/abs/pii/S1521691817300999
677. Yen P-C, Geng J-H, Wu P-Y, Huang J-C, Hu H-M, Kuo C-H and Chen S-C (2024) Secondhand smoke is associated with peptic ulcer disease and gastroesophageal reflux disease in non-smokers in a large Taiwanese population study. Front. Public Health. 12:1450481. doi: 10.3389/fpubh.2024.1450481
https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2024.1450481/full
678. Gomm W, von Holt K, Thomé F, et al. Association of Proton Pump Inhibitors With Risk of Dementia: A Pharmacoepidemiological Claims Data Analysis. JAMA Neurol. 2016;73(4):410–416. doi:10.1001/jamaneurol.2015.4791
https://jamanetwork.com/journals/jamaneurology/fullarticle/2487379
679. Ortiz-Guerrero G, Amador-Muñoz D, Calderón-Ospina CA, López-Fuentes D, Nava Mesa MO. Proton Pump Inhibitors and Dementia: Physiopathological Mechanisms and Clinical Consequences. Neural Plast. 2018 Mar 21;2018:5257285. doi: 10.1155/2018/5257285. PMID: 29755512; PMCID: PMC5883984.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5883984/
680. Northuis CA, Bell EJ, Lutsey PL, George KM, Gottesman RF, Mosley TH, Whitsel EA, Lakshminarayan K. Cumulative Use of Proton Pump Inhibitors and Risk of Dementia: The Atherosclerosis Risk in Communities Study. Neurology. 2023 Oct 31;101(18):e1771-e1778. doi: 10.1212/WNL.0000000000207747. Epub 2023 Aug 9. Erratum in: Neurology. 2024 Jul 9;103(1):e209596. doi: 10.1212/WNL.0000000000209596. PMID: 37558503; PMCID: PMC10634644.
https://www.neurology.org/doi/10.1212/WNL.0000000000207747
681. Common questions about esomeprazole, 7 January 2022 NHS of UK
https://www.nhs.uk/medicines/esomeprazole/common-questions-about-esomeprazole/
682. Published July 19, 2017 GASTROENTEROLOGY Proton Pump Inhibitors: Considerations With Long-Term Use, Emily M. Ambizas, PharmD, MPH, BCGP, Joseph V. Etzel, PharmD
https://www.uspharmacist.com/article/proton-pump-inhibitors-considerations-with-longterm-use
683. Maideen NMP. Adverse Effects Associated with Long-Term Use of Proton Pump Inhibitors. Chonnam Med J. 2023 May;59(2):115-127. doi: 10.4068/cmj.2023.59.2.115. Epub 2023 May 25. PMID: 37303818; PMCID: PMC10248387.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10248387/
Εμμηνόπαυση
1. Vikram Talaulikar, Menopause transition: Physiology and symptoms, Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 81, 2022, Pages 3-7, ISSN 1521-6934, https://doi.org/10.1016/j.bpobgyn.2022.03.003.
https://www.sciencedirect.com/science/article/abs/pii/S1521693422000426,
2. Jeong HG, Park H. Metabolic Disorders in Menopause. Metabolites. 2022 Oct 8;12(10):954. doi: 10.3390/metabo12100954. PMID: 36295856; PMCID: PMC9606939.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9606939/
3. Peacock K, Carlson K, Ketvertis KM. Menopause. [Updated 2023 Dec 21]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK507826/
4. Menopause 16 October 2024, WHO
https://www.who.int/news-room/fact-sheets/detail/menopause
5. Medicinal Mushrooms (PDQ®)–Patient Version, July 11, 2024, National Cancer Institute at the National Institutes of Health
https://www.cancer.gov/about-cancer/treatment/cam/patient/mushrooms-pdq
6. Yoshimoto, H.; Miyazawa, N.; Eguchi, F. Wild and Cultivated Mushrooms Exhibit Anti-Inflammatory Effects Including Inhibition of Platelet Aggregation and Interleukin-8 Expression. Appl. Microbiol. 2025, 5, 36. https://doi.org/10.3390/applmicrobiol5020036
https://www.mdpi.com/2673-8007/5/2/36
7. Wasser SP. Medicinal Mushrooms in Human Clinical Studies. Part I. Anticancer, Oncoimmunological, and Immunomodulatory Activities: A Review. Int J Med Mushrooms. 2017;19(4):279-317. doi: 10.1615/IntJMedMushrooms.v19.i4.10. PMID: 28605319.
https://pubmed.ncbi.nlm.nih.gov/28605319/
8. International Journal of Medicinal Mushrooms Editor-in-Chief: Solomon P. Wasser
https://www.begellhouse.com/journals/medicinal-mushrooms.html
9. Meade E, Hehir S, Rowan N, Garvey M. Mycotherapy: Potential of Fungal Bioactives for the Treatment of Mental Health Disorders and Morbidities of Chronic Pain. J Fungi (Basel). 2022 Mar 11;8(3):290. doi: 10.3390/jof8030290. PMID: 35330292; PMCID: PMC8954642.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8954642/
10. Conde DM, Verdade RC, Valadares ALR, Mella LFB, Pedro AO, Costa-Paiva L. Menopause and cognitive impairment: A narrative review of current knowledge. World J Psychiatry. 2021 Aug 19;11(8):412-428. doi: 10.5498/wjp.v11.i8.412. PMID: 34513605; PMCID: PMC8394691.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8394691/
11. Maki PM, Jaff NG. Menopause and brain fog: how to counsel and treat midlife women. Menopause. 2024 Jul 1;31(7):647-649. doi: 10.1097/GME.0000000000002382. Epub 2024 Jun 17. PMID: 38888619.
https://pubmed.ncbi.nlm.nih.gov/38888619/
12. Menopause and brain fog: What’s the link? Research ties severity of certain menopause symptoms to cognitive performance. June 1, 2022 By Maureen Salamon, Executive Editor, Harvard Women’s Health Watch
https://www.health.harvard.edu/womens-health/menopause-and-brain-fog-whats-the-link
13. Sabaratnam V, Kah-Hui W, Naidu M, Rosie David P. Neuronal health – can culinary and medicinal mushrooms help? J Tradit Complement Med. 2013 Jan;3(1):62-8. doi: 10.4103/2225-4110.106549. PMID: 24716157; PMCID: PMC3924982.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3924982/
14. Sara Cha, Lynne Bell, Barbara Shukitt-Hale, Claire M. Williams, A review of the effects of mushrooms on mood and neurocognitive health across the lifespan, Neuroscience & Biobehavioral Reviews, Volume 158, 2024, 105548, ISSN 0149-7634, https://doi.org/10.1016/j.neubiorev.2024.105548.
https://www.sciencedirect.com/science/article/pii/S0149763424000162
15. Ban, S.; Do, T.T.; Pyo, J.-W.; Moon, M.; Park, J.-T. INO10, a Chaga Mushroom Extract, Alleviates Alzheimer’s Disease-Related Pathology and Cognitive Deficits in 3xTg-AD Mice. Int. J. Mol. Sci. 2025, 26, 4729. https://doi.org/10.3390/ijms26104729
https://www.mdpi.com/1422-0067/26/10/4729
16. Benjarong Thongbai, Sylvie Rapior, Kevin Hyde, Kathrin Wittstein, Marc Stadler. Hericium erinaceus, an amazing medicinal mushroom. Mycological Progress, 2015, 14 (10), pp.91, doi:10.1007/s11557-015-1105-4. 10.1007/s11557-015-1105-4. hal-02196151
https://hal.umontpellier.fr/hal-02196151v1/document
17. News Mushrooms magnify memory by boosting nerve growth 10 February 2023, The University of Queensland
https://news.uq.edu.au/2023-02-10-mushrooms-magnify-memory-boosting-nerve-growth
18. Are Mushroom Supplements the Key to Boosting Your Brain Health? More research is needed, but they may be worth a try, LaKeisha Fleming, February 04, 2025, Medically reviewed by Steven Gans, MD, Verywell Mind
https://www.verywellmind.com/mushroom-supplements-for-brain-health-8784675
19. Martínez-Mármol, R., Chai, Y., Conroy, J. N., Khan, Z., Hong, S.-M., Kim, S. B., Gormal, R. S., Lee, D. H., Lee, J. K., Coulson, E. J., Lee, M. K., Kim, S. Y., & Meunier, F. A. (2023). Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory. Journal of Neurochemistry, 165, 791–808. https://doi.org/10.1111/jnc.15767
https://onlinelibrary.wiley.com/doi/10.1111/jnc.15767
20. Oliwia Koszła, Wirginia Kukula-Koch, Krzysztof Jóźwiak, Rafał Jastrząb, Małgorzata Anna Marć, Jennifer Mytych, Anna Tabęcka-Łonczyńska, Bartosz Skóra, Konrad A. Szychowski, Przemysław Sołek, Biotransformation of Ganoderma lucidum and Hericium erinaceus for ex vivo gut-brain axis modulation and mood-related outcomes in humans: CREB/BDNF signaling and microbiota-driven synergies, Journal of Ethnopharmacology, Volume 342, 2025, 119393, ISSN 0378-8741, https://doi.org/10.1016/j.jep.2025.119393.
https://www.sciencedirect.com/science/article/abs/pii/S0378874125000765
21. Contato, A.G.; Conte-Junior, C.A. Lion’s Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential—A Narrative Review. Nutrients 2025, 17, 1307. https://doi.org/10.3390/nu17081307
https://www.mdpi.com/2072-6643/17/8/1307
22. Shaik, Aminabee & Dasari, Santhi & Shankar, Kunderu Ravi & Manasa, G. & Manikanta, Siram & Nirmala, Nalam & Chandrika, Lingineni & Karthik, Siddineni & Evangel, Nakka. (2025). Exploring the Neuroprotective Potential of Functional Mushrooms: A Comprehensive Review. Journal of Natural Remedies. 1299-1308. 10.18311/jnr/2025/49048.
https://www.researchgate.net/publication/393287089_Exploring_the_Neuroprotective_Potential_of_Functional_Mushrooms_A_Comprehensive_Review
23. Martínez-Mármol, R., Chai, Y., Conroy, J. N., Khan, Z., Hong, S.-M., Kim, S. B., Gormal, R. S., Lee, D. H., Lee, J. K., Coulson, E. J., Lee, M. K., Kim, S. Y., & Meunier, F. A. (2023). Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory. Journal of Neurochemistry, 165, 791–808. https://doi.org/10.1111/jnc.15767
https://onlinelibrary.wiley.com/doi/10.1111/jnc.15767
24. Xu-Jia Chen, Zhou Deng, Le-Le Zhang, Yan Pan, Jia Fu, Liang Zou, Zhaofang Bai, Xiaohe Xiao, Feiya Sheng, Therapeutic potential of the medicinal mushroom Ganoderma lucidum against Alzheimer’s disease, Biomedicine & Pharmacotherapy, Volume 172, 2024, 116222, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2024.116222.
https://www.sciencedirect.com/science/article/pii/S0753332224001033
25. Menon A, Jalal A, Arshad Z, Nawaz FA and Kashyap R (2025) Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review. Front. Nutr. 12:1641246. doi: 10.3389/fnut.2025.1641246
https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1641246/full
26. Szućko-Kociuba I, Trzeciak-Ryczek A, Kupnicka P, Chlubek D. Neurotrophic and Neuroprotective Effects of Hericium erinaceus. Int J Mol Sci. 2023 Nov 3;24(21):15960. doi: 10.3390/ijms242115960. PMID: 37958943; PMCID: PMC10650066.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10650066/
27. Sachchida Nand Rai, Divya Mishra, Payal Singh, Emanuel Vamanu, M.P. Singh, Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases, Biomedicine & Pharmacotherapy, Volume 137, 2021, 111377, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2021.111377.
https://www.sciencedirect.com/science/article/pii/S0753332221001621
28. Lai PL, Naidu M, Sabaratnam V, Wong KH, David RP, Kuppusamy UR, Abdullah N, Malek SN. Neurotrophic properties of the Lion’s mane medicinal mushroom, Hericium erinaceus (Higher Basidiomycetes) from Malaysia. Int J Med Mushrooms. 2013;15(6):539-54. doi: 10.1615/intjmedmushr.v15.i6.30. PMID: 24266378.
https://pubmed.ncbi.nlm.nih.gov/24266378/
29. Hericerin derivatives from Hericium erinaceus exert BDNF-like neurotrophic activity in central hippocampal neurons and enhance memory Ramón Martínez-Mármol, YeJin Chai, Zahra Khan, Seon Beom Kim, Seong Min Hong, Rachel S. Gormal, Dae Hee Lee, Jae Kang Lee, Mi Kyeong Lee, Sun Yeou Kim, Frédéric A. Meunier bioRxiv 2020.08.28.271676; doi: https://doi.org/10.1101/2020.08.28.271676
https://www.biorxiv.org/content/10.1101/2020.08.28.271676v1.full
30. Bell V, Dimitrov P, Fernandes T. Supporting Neurologic Health with Mushroom Nutrition. Nutrients. 2025 May 2;17(9):1568. doi: 10.3390/nu17091568. PMID: 40362877; PMCID: PMC12073738.
https://www.mdpi.com/2072-6643/17/9/1568
31. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009 Mar;23(3):367-72. doi: 10.1002/ptr.2634. PMID: 18844328.
https://pubmed.ncbi.nlm.nih.gov/18844328/
32. Li IC, Chang HH, Lin CH, et al. Prevention of Early Alzheimer’s Disease by Erinacine A-Enriched <i>Hericium erinaceus</i> Mycelia Pilot Double-Blind Placebo-Controlled Study. Frontiers in Aging Neuroscience. 2020;12:155. DOI: 10.3389/fnagi.2020.00155. PMID: 32581767; PMCID: PMC7283924.
https://europepmc.org/article/MED/32581767
33. Li IC, Lee LY, Tzeng TT, Chen WP, Chen YP, Shiao YJ, Chen CC. Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines. Behav Neurol. 2018 May 21;2018:5802634. doi: 10.1155/2018/5802634. PMID: 29951133; PMCID: PMC5987239.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987239/
34. Saitsu Y, Nishide A, Kikushima K, Shimizu K, Ohnuki K. Improvement of cognitive functions by oral intake of Hericium erinaceus. Biomed Res. 2019;40(4):125-131. doi: 10.2220/biomedres.40.125. PMID: 31413233.
https://pubmed.ncbi.nlm.nih.gov/31413233/
35. La Monica MB, Raub B, Ziegenfuss EJ, Hartshorn S, Grdic J, Gustat A, Sandrock J, Ziegenfuss TN. Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion’s Mane Extracts on Cognitive Performance. Nutrients. 2023 Dec 6;15(24):5018. doi: 10.3390/nu15245018. PMID: 38140277; PMCID: PMC10745489.
https://pubmed.ncbi.nlm.nih.gov/38140277/
https://www.mdpi.com/2072-6643/15/24/5018
36. The reality of menopause weight gain Many women gain weight as they age, but extra pounds aren’t inevitable. To help ease weight gain, step up your activity level and enjoy a healthy diet. Mayo Clinic Staff, July 08, 2023
https://www.mayoclinic.org/healthy-lifestyle/womens-health/in-depth/menopause-weight-gain/art-20046058
37. Ann R. Lurati, Effects of Menopause on Appetite and the Gastrointestinal System, Nursing for Women’s Health, Volume 22, Issue 6, 2018, Pages 499-505, ISSN 1751-4851, https://doi.org/10.1016/j.nwh.2018.09.004.
https://www.sciencedirect.com/science/article/abs/pii/S1751485118301983
38. Review Role of Ghrelin in Postmenopausal obesity Mona Mohamed Ibrahim Abdalla1,2, Ravindran Jegasothy2 1Human Biology Department, School of Medicine, International Medical University, Malaysia 2Faculty of Medicine, MAHSA University, Malaysia IJWHR 2020; 8: 119-124 DOI: 10.15296/ijwhr.2020.19
https://www.ijwhr.net/text.php?id=448
39. Precious U. Ezurike, Evelyn Odunola, Tolulope A. Oke, Adewale G. Bakre, Oluwayimika Olumide, OgoOluwa Odetoye, Adenike M. Alege, Oyindamola O. Abiodun, Ganoderma lucidum ethanol extract promotes weight loss and improves depressive-like behaviors in male and female Swiss mice, Physiology & Behavior, Volume 265, 2023, 114155, ISSN 0031-9384, https://doi.org/10.1016/j.physbeh.2023.114155.
https://www.sciencedirect.com/science/article/abs/pii/S0031938423000835
40. Eshita Sharma, Rakesh Bairwa, Priyanka Lal, Sudeepta Pattanayak, Kota Chakrapani, Rajendra Poorvasandhya, Awadhesh Kumar, Muhammad Ahsan Altaf, Rahul Kumar Tiwari, Milan Kumar Lal, Ravinder Kumar, Edible mushrooms trending in food: Nutrigenomics, bibliometric, from bench to valuable applications, Heliyon, Volume 10, Issue 17, 2024, e36963, ISSN 2405-8440, https://doi.org/10.1016/j.heliyon.2024.e36963.
https://www.sciencedirect.com/science/article/pii/S2405844024129945
41. Ganesan K, Xu B. Anti-Obesity Effects of Medicinal and Edible Mushrooms. Molecules. 2018 Nov 5;23(11):2880. doi: 10.3390/molecules23112880. PMID: 30400600; PMCID: PMC6278646.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6278646/
42. Holmes, D. Medicinal mushroom reduces obesity by modulating microbiota. Nat Rev Endocrinol 11, 504 (2015). https://doi.org/10.1038/nrendo.2015.114
https://www.nature.com/articles/nrendo.2015.114
43. Alvandi, H., Ansari, E. ., Kianirad, S. ., Hatamian-Zarmi, A., Mokhtari Hosseini, Z. B., & Ebrahimi-Hosseinzadeh, B. (2022). Medicinal mushrooms as potential therapeutic agents in the treatment of diabetes mellitus: a review with focusing on in vivo and clinical studies. Italian Journal of Mycology, 51(1), 75–96. https://doi.org/10.6092/issn.2531-7342/15023
https://italianmycology.unibo.it/article/view/15023
44. Mushroom coffee: Worth a taste? June 4, 2024 By Lindsay Warner, Content Licensing Editor, Harvard Health Publishing
https://www.health.harvard.edu/nutrition/mushroom-coffee-worth-a-taste
45. Łysakowska P, Sobota A, Wirkijowska A. Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review. Molecules. 2023 Jul 14;28(14):5393. doi: 10.3390/molecules28145393. PMID: 37513265; PMCID: PMC10384337.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10384337/
46. Volume 1, Issue 2 (November 2022), Health Science Monitor 2022, 1(2): 107-108 Does Ganoderma lucidum reduce obesity? Ameneh Marzban , Abdolrazagh Marzban , Payam Emami * Department of Emergency Medical Sciences, School of Paramedical Sciences, Kurdistan University of Medical Sciences, Sanandaj, Iran
https://hsm.umsu.ac.ir/browse.php?a_id=46&sid=1&slc_lang=en
47. Stamatia-Angeliki Kleftaki, Stamatia Simati, Charalampia Amerikanou, Aristea Gioxari, Chara Tzavara, Georgios I. Zervakis, Nick Kalogeropoulos, Alexander Kokkinos, Andriana C. Kaliora, Pleurotus eryngii improves postprandial glycaemia, hunger and fullness perception, and enhances ghrelin suppression in people with metabolically unhealthy obesity, Pharmacological Research, Volume 175, 2022, 105979, ISSN 1043-6618, https://doi.org/10.1016/j.phrs.2021.105979.
https://www.sciencedirect.com/science/article/abs/pii/S1043661821005636
48. Son EH, Jung DH, Shin H, Lee S, Kim Y, Lim HS. Effects of the Intestinal Status and Clinical Factors of Korean Middle-Aged People Through the Consumption of Functional Foods Containing Auricularia auricula-judae Powder: Prospective, Randomized, Open-Label, and Control Comparative Trial. Clin Nutr Res. 2025 Jan 22;14(1):7-16. doi: 10.7762/cnr.2025.14.1.7. PMID: 39968271; PMCID: PMC11832288.
https://pubmed.ncbi.nlm.nih.gov/39968271/
49. Mendes LC. Effective fuling (Poria Cocos) for the treatment of obesity? Int J Complement Alt Med. 2018;11(6):380-385. DOI: 10.15406/ijcam.2018.11.00430
https://medcraveonline.com/IJCAM/effective-fuling-poria-cocos-for-the-treatment-of-obesity.html
https://www.researchgate.net/publication/329950997_Effective_fuling_Poria_Cocos_for_the_treatment_of_obesity
51. How Can Menopause Affect Sleep Updated January 18, 2024 Lucy Bryan Contributing Writer Lucy Bryan Alyssa Dweck, MD, FACOG Medically Reviewed by Alyssa Dweck, MD, FACOG
https://www.sleepfoundation.org/women-sleep/menopause-and-sleep
52. Maki PM, Panay N, Simon JA. Sleep disturbance associated with the menopause. Menopause. 2024 Aug 1;31(8):724-733. doi: 10.1097/GME.0000000000002386. Epub 2024 Jun 25. PMID: 38916279.
https://pubmed.ncbi.nlm.nih.gov/38916279/
53. Qiu Y, Mao ZJ, Ruan YP, Zhang X. Exploration of the anti-insomnia mechanism of Ganoderma by central-peripheral multi-level interaction network analysis. BMC Microbiol. 2021 Oct 29;21(1):296. doi: 10.1186/s12866-021-02361-5. PMID: 34715778; PMCID: PMC8555286.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555286/
54. Wei Chen, Jun-Wen Yu, Yu-Yi Deng, Lut Yi Wong, Chen Wang, Yu-Ling Liang, Yuk-Tung Leung, Jia-Yi Tian, Ying Wu, Kelvin Sze-Yin Leung, Jinhui Hu, Wen-Hua Chen, Xiaobing Dou, Xiu-Qiong Fu, Ying-Jie Chen, Zhi-Ling Yu, Identification of sedative-hypnotic compounds shared by five medicinal Polyporales mushrooms using UPLC-Q-TOF-MS/MS-based untargeted metabolomics, Phytomedicine, Volume 128, 2024, 155355, ISSN 0944-7113, https://doi.org/10.1016/j.phymed.2024.155355.
https://www.sciencedirect.com/science/article/abs/pii/S0944711324000205
55. Tselepis, George & Palamiotis, Ioannis & Georgiou, Sofia. (2023). Homeostasis of Circadian Rhythm and Therapeutic Approaches to Manage its Related-Disorders: The Case of Medicinal Mushrooms Rich in Melatonin. Med Discoveries. 2. 10.52768/2993-1142/1075.
https://www.researchgate.net/publication/375439212_Homeostasis_of_Circadian_Rhythm_and_Therapeutic_Approaches_to_Manage_its_Related-Disorders_The_Case_of_Medicinal_Mushrooms_Rich_in_Melatonin
56. Kim H, Choi H, Park BG, Ju HJ, Kim YI. Efficacy of Poria Cocos Extract on Sleep Quality Enhancement: A Clinical Perspective with Implications for Functional Foods. Nutrients. 2023 Oct 1;15(19):4242. doi: 10.3390/nu15194242. PMID: 37836526; PMCID: PMC10574255.
https://pubmed.ncbi.nlm.nih.gov/37836526/
57. Qiu Y, Mao ZJ, Ruan YP, Zhang X. Exploration of the anti-insomnia mechanism of Ganoderma by central-peripheral multi-level interaction network analysis. BMC Microbiol. 2021 Oct 29;21(1):296. doi: 10.1186/s12866-021-02361-5. PMID: 34715778; PMCID: PMC8555286.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555286/
58. Vigna L, Morelli F, Agnelli GM, et al. <i>Hericium erinaceus</i> Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? Evidence-based Complementary and Alternative Medicine : Ecam. 2019 ;2019:7861297. DOI: 10.1155/2019/7861297. PMID: 31118969; PMCID: PMC6500611.
https://europepmc.org/article/MED/31118969
59. Brandalise F, Roda E, Ratto D, Goppa L, Gargano ML, Cirlincione F, Priori EC, Venuti MT, Pastorelli E, Savino E, Rossi P. Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline? J Fungi (Basel). 2023 May 10;9(5):551. doi: 10.3390/jof9050551. PMID: 37233262; PMCID: PMC10218917.
https://pubmed.ncbi.nlm.nih.gov/37233262/
60. Okamura, Hisayoshi & Anno, Nobuko & Tsuda, Akira & Inokuchi, Takahiro & Uchimura, Naohisa & Inanaga, Kazutoyo. (2015). The effects of Hericium erinaceus (Amyloban® 3399) on sleep quality and subjective well-being among female undergraduate students: A pilot study. Personalized Medicine Universe. 4. 10.1016/j.pmu.2015.03.006.
https://www.researchgate.net/publication/276152143_The_effects_of_Hericium_erinaceus_AmylobanR_3399_on_sleep_quality_and_subjective_well-being_among_female_undergraduate_students_A_pilot_study
61. Exploring the Uses of the Top Medicinal Mushrooms, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Tarikh Input: 22/02/2023 | Kemaskini: 04/04/2023 | aslamiah
https://sgs.upm.edu.my/artikel/exploring_the_uses_of_the_top_medicinal_mushrooms-71534
62. Lu J, Su M, Zhou X, Li D, Niu X, Wang Y. Research Progress of Bioactive Components in Sanghuangporus spp. Molecules. 2024 Mar 7;29(6):1195. doi: 10.3390/molecules29061195. PMID: 38542832; PMCID: PMC10976032.
https://pubmed.ncbi.nlm.nih.gov/38542832/
63. Yao L, Lv J, Duan C, An X, Zhang C, Li D, Li C, Liu S. Armillaria mellea fermentation liquor ameliorates p-chlorophenylalanine-induced insomnia associated with the modulation of serotonergic system and gut microbiota in rats. J Food Biochem. 2022 Feb;46(2):e14075. doi: 10.1111/jfbc.14075. Epub 2022 Jan 5. PMID: 34984694.
https://pubmed.ncbi.nlm.nih.gov/34984694/
64. Sharma H, Sharma N, An SSA. Unique Bioactives from Zombie Fungus (Cordyceps) as Promising Multitargeted Neuroprotective Agents. Nutrients. 2023 Dec 27;16(1):102. doi: 10.3390/nu16010102. PMID: 38201932; PMCID: PMC10780653.
https://pubmed.ncbi.nlm.nih.gov/38201932/
65. Tan YF, Mo JS, Wang YK, Zhang W, Jiang YP, Xu KP, Tan GS, Liu S, Li J, Wang WX. The ethnopharmacology, phytochemistry and pharmacology of the genus Hericium. J Ethnopharmacol. 2024 Jan 30;319(Pt 3):117353. doi: 10.1016/j.jep.2023.117353. Epub 2023 Oct 29. PMID: 37907145.
https://pubmed.ncbi.nlm.nih.gov/37907145/
66. Published April 20, 2009 COMPLEMENTARY and ALTERNATIVE MEDICINE Adaptogenic or Medicinal Mushrooms M. Saljoughian, PharmD, PhD
https://www.uspharmacist.com/article/adaptogenic-or-medicinal-mushrooms
67. Yao, C., Wang, Z., Jiang, H. et al. Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice. Sci Rep 11, 13660 (2021). https://doi.org/10.1038/s41598-021-92913-6
https://www.nature.com/articles/s41598-021-92913-6
68. Batra P, Sharma AK, Khajuria R. Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. Int J Med Mushrooms. 2013;15(2):127-43. doi: 10.1615/intjmedmushr.v15.i2.20. PMID: 23557365.
https://pubmed.ncbi.nlm.nih.gov/23557365/
69. Lee KH, Morris-Natschke SL, Yang X, Huang R, Zhou T, Wu SF, Shi Q, Itokawa H. Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine. J Tradit Complement Med. 2012 Apr;2(2):84-95. PMID: 24716120; PMCID: PMC3942920.
https://core.ac.uk/download/pdf/82062841.pdf
70. Reishi Cultivation The mushroom of immortality, Michael den Herder, European Forest Institute, [email protected] April 2022
https://efi.int/sites/default/files/files/knowledge/projects/EFI_Reishi_Cultivation_EN.pdf
71. Sanodiya BS, Thakur GS, Baghel RK, Prasad GB, Bisen PS. Ganoderma lucidum: a potent pharmacological macrofungus. Curr Pharm Biotechnol. 2009 Dec;10(8):717-42. doi: 10.2174/138920109789978757. PMID: 19939212.
https://pubmed.ncbi.nlm.nih.gov/19939212/
72. Yao C, Wang Z, Jiang H, Yan R, Huang Q, Wang Y, Xie H, Zou Y, Yu Y, Lv L. Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice. Sci Rep. 2021 Jul 1;11(1):13660. doi: 10.1038/s41598-021-92913-6. PMID: 34211003; PMCID: PMC8249598.
https://pubmed.ncbi.nlm.nih.gov/34211003/
73. Jia, Ling-Feng & Chen, Ping & Qu, Gui-Da & Sun, Ning & Guo, Tao & Zhong, Huai-Yu & Duan, Yi-Han & Sun, Jia-Hui & Sun, Jing-Bo. (2025). A comprehensive review of the sedative-hypnotic mechanisms of edible fungi. Food & Medicine Homology. 10.26599/FMH.2025.9420049.
https://www.sciopen.com/article/10.26599/FMH.2025.9420049
https://www.researchgate.net/publication/395136109_A_comprehensive_review_of_the_sedative-hypnotic_mechanisms_of_edible_fungi
74. March 28, 2025/Living Healthy/Women’s Health Can Menopause Cause Anxiety? Cleveland Clinic
https://health.clevelandclinic.org/is-menopause-causing-your-mood-swings-depression-or-anxiety
75. Can Menopause Cause Depression? The Johns Hopkins University
https://www.hopkinsmedicine.org/health/wellness-and-prevention/can-menopause-cause-depression
76. Better Psychological Well-Being Through Menopause, SWAN Study
https://www.swanstudy.org/womens-health-info/better-psychological-well-being-through-menopause/
77. Lazur J, Hnatyk K, Kała K, Sułkowska-Ziaja K, Muszyńska B. Discovering the Potential Mechanisms of Medicinal Mushrooms Antidepressant Activity: A Review. Antioxidants (Basel). 2023 Mar 2;12(3):623. doi: 10.3390/antiox12030623. PMID: 36978872; PMCID: PMC10044934.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10044934/
78. Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, Ohnuki K. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res. 2010 Aug;31(4):231-7. doi: 10.2220/biomedres.31.231. PMID: 20834180.
https://pubmed.ncbi.nlm.nih.gov/20834180
79. Mitra S, Mitra M, Nandi DK, Saha M, Bandyopadhyay A. Efficacy of Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Supplementation on Psychological Stress and Selective Fitness Profile Parameters in Female College Students in West Bengal, India. Int J Med Mushrooms. 2024;26(11):51-64. doi: 10.1615/IntJMedMushrooms.2024055300. PMID: 39241163.
https://pubmed.ncbi.nlm.nih.gov/39241163/
80. Evid Based Complement Alternat Med, 2019, 7861297 2019 Apr 18 eCollection 2019 Hericium erinaceus Improves Mood and Sleep Disorders in Patients Affected by Overweight or Obesity: Could Circulating Pro-BDNF and BDNF Be Potential Biomarkers? Luisella Vigna, Federica Morelli, Gianna M Agnelli, Filomena Napolitano, Daniela Ratto, Alessandra Occhinegro, Carmine Di Iorio, Elena Savino, Carolina Girometta, Federico Brandalise, Paola Rossi
https://europepmc.org/article/MED/31118969
81. Kazutoyo Inanaga, Marked improvement of neurocognitive impairment after treatment with compounds from Hericium erinaceum: A case study of recurrent depressive disorder, Personalized Medicine Universe, Volume 3, 2014, Pages 46-48, ISSN 2186-4950, https://doi.org/10.1016/j.pmu.2014.02.004.
https://www.sciencedirect.com/science/article/abs/pii/S2186495014000108?via%3Dihub
82. Limanaqi F, Biagioni F, Busceti CL, Polzella M, Fabrizi C, Fornai F. Potential Antidepressant Effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea. Antioxidants (Basel). 2020 Mar 12;9(3):234. doi: 10.3390/antiox9030234. PMID: 32178272; PMCID: PMC7139475.
https://pubmed.ncbi.nlm.nih.gov/32178272/
83. Thyroid and menopause article, British Thyroid Foundation, May 2023
https://www.btf-thyroid.org/thyroid-and-menopause-article
84. Frank-Raue K, Raue F. Thyroid Dysfunction in Periand Postmenopausal Women-Cumulative Risks. Dtsch Arztebl Int. 2023 May 5;120(18):311-316. doi: 10.3238/arztebl.m2023.0069. PMID: 37013812; PMCID: PMC10398375.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10398375/
85. ZHAO Ze-fei, ZHAO Yong-ju, GU Ming-jun, et al. Effect of Ganoderma lucidum polysaccharides on hyperthyroidism and liver injury in Graves´|disease mice model[J]. , 2013, 33(5): 607-.
https://xuebao.shsmu.edu.cn/EN/10.3969/j.issn.1674-8115.2013.05.020
86. Lu YZ, Wu XX, Chen S, Yuan J, Lai CH, Bao LL, Sun LH, Lu W. Effectiveness of Ganoderma lucidum preparation in treating simian acquired immune deficiency syndrome. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2011 Jun;33(3):318-24. doi: 10.3881/j.issn.1000-503X.2011.03.021. PMID: 21718617.
https://pubmed.ncbi.nlm.nih.gov/21718617/
87. Wei B, Zhang R, Zhai J, Zhu J, Yang F, Yue D, Liu X, Lu C, Sun X. Suppression of Th17 Cell Response in the Alleviation of Dextran Sulfate Sodium-Induced Colitis by Ganoderma lucidum Polysaccharides. J Immunol Res. 2018 May 20;2018:2906494. doi: 10.1155/2018/2906494. PMID: 29888292; PMCID: PMC5985119.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5985119/
88. Hsu HY, Kuan YC, Lin TY, Tsao SM, Hsu J, Ma LJ, Sheu F. Reishi Protein LZ-8 Induces FOXP3(+) Treg Expansion via a CD45-Dependent Signaling Pathway and Alleviates Acute Intestinal Inflammation in Mice. Evid Based Complement Alternat Med. 2013;2013:513542. doi: 10.1155/2013/513542. Epub 2013 Jun 24. PMID: 23864893; PMCID: PMC3707273.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3707273/
89. Dandapat, Sukumar & Srivastava, Rohit & Sinha, Manoranjan. (2021). Study on impact of silver nanoparticles synthesized using aqueous extract of Ganoderma applanatum on thyroid and lipid parameters of albino rat. Anales de Biología. 43. 123-137. 10.6018/analesbio.43.14.
https://www.um.es/analesdebiologia/numeros/43/PDF/43_2021_14.pdf
90. Qiu, Y., Mao, ZJ., Ruan, YP. et al. Exploration of the anti-insomnia mechanism of Ganoderma by central-peripheral multi-level interaction network analysis. BMC Microbiol 21, 296 (2021). https://doi.org/10.1186/s12866-021-02361-5
https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-021-02361-5
91. Pazzi, F.; Adsuar, J.C.; Domínguez-Muñoz, F.J.; García-Gordillo, M.A.; Gusi, N.; Collado-Mateo, D. Ganoderma lucidum Effects on Mood and Health-Related Quality of Life in Women with Fibromyalgia. Healthcare 2020, 8, 520. https://doi.org/10.3390/healthcare8040520
https://www.mdpi.com/2227-9032/8/4/520
92. Plosca, M.-P.; Chiș, M.S.; Fărcaș, A.C.; Păucean, A. Ganoderma lucidum—From Ancient Remedies to Modern Applications: Chemistry, Benefits, and Safety. Antioxidants 2025, 14, 513. https://doi.org/10.3390/antiox14050513
https://www.mdpi.com/2076-3921/14/5/513
93. Zheng DS, Chen LS. Triterpenoids from Ganoderma lucidum inhibit the activation of EBV antigens as telomerase inhibitors. Exp Ther Med. 2017 Oct;14(4):3273-3278. doi: 10.3892/etm.2017.4883. Epub 2017 Aug 3. PMID: 28912878; PMCID: PMC5585879.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5585879/
94. Cör Andrejč D, Knez Ž, Knez Marevci M. Antioxidant, antibacterial, antitumor, antifungal, antiviral, anti-inflammatory, and nevro-protective activity of Ganoderma lucidum: An overview. Front Pharmacol. 2022 Jul 22;13:934982. doi: 10.3389/fphar.2022.934982. PMID: 35935849; PMCID: PMC9353308.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9353308/
95. Sijia Wu, Siyuan Zhang, Bo Peng, Dechao Tan, Mingyue Wu, Jinchao Wei, Yitao Wang, Hua Luo, Ganoderma lucidum: a comprehensive review of phytochemistry, efficacy, safety and clinical study, Food Science and Human Wellness, Volume 13, Issue 2, 2024, Pages 568-596, ISSN 2213-4530, https://doi.org/10.26599/FSHW.2022.9250051.
https://www.sciencedirect.com/science/article/pii/S2213453023001854
96. Iwatsuki K, Akihisa T, Tokuda H, Ukiya M, Oshikubo M, Kimura Y, Asano T, Nomura A, Nishino H. Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation. J Nat Prod. 2003 Dec;66(12):1582-5. doi: 10.1021/np0302293. PMID: 14695801.
https://pubmed.ncbi.nlm.nih.gov/14695801/
97. Natural Endocrine Solutions, September 15, 2022, The Role of Medicinal Mushrooms in Graves’ Disease and Hashimoto’s,
https://www.naturalendocrinesolutions.com/2022/09/15/the-role-of-medicinal-mushrooms-in-graves-disease-and-hashimotos/
98. Herbs for Hypothyroid, Dr. Tara Burke,
https://drtaraburke.com/herbs-for-hypothyroid/
99. How Medicinal Mushrooms Can Improve Your Thyroid Health, Aggie McCabe, July 13, 2024
https://aggiemccabe.com/2024/07/medicinal-mushrooms-for-thyroid-health
100. Treating Thyroid Disease: A Natural Approach to Healing Hashimoto’s, Melissa Lea-Foster Rietz, FNP-BC, BC-ADM, RYT-200 Presbyterian Medical Services Farmington, NM
https://cdn.ymaws.com/www.nmnpc.org/resource/resmgr/2016_conference/presentations/rietz_thyroid_final.pdf
101. Adaptogenic Herbs and Hashimoto’s Disease, 7.5.2022, Written by: Julia Walker, RN, BSN Medically Reviewed by: Ellen Landes, Paloma Health
https://www.palomahealth.com/learn/adaptogenic-herbs-hashimotos?srsltid=AfmBOooC8nKemf2SecCRJ2iOW3ZkOma3M0ysT9ZfcHZLhFSYHO_mB7sd
102. Controversy: Is Coffee Bad For Your Thyroid? Medically reviewed and written by Izabella Wentz, PharmD, FASCP Dr. Izabella Wentz / February 2, 2024
https://thyroidpharmacist.com/articles/controversy-coffee-bad-thyroid-myths-truths/
103. We Analyzed Mushrooms For Thyroid Health: Our Expert Take by Sony Sherpa Updated On: June 15, 2023
https://www.naturesrise.com/blogs/brainfood/mushrooms-for-thyroid?srsltid=AfmBOopcbHE4S3T8GPVBcR_efFCF7GZZg3S1GI_GUaIoB1OZOErzpXm_
104. Herbal Medicines for Thyroid Disorders Dr. Nikolas Hedberg In Hashimoto’s Disease, Thyroid
https://drhedberg.com/herbal-medicines-for-thyroid-disorders/
105. Environmental Origins of Thyroid Disease – Part 1 Origins of Thyroid Disease – Yarrow – achillea_millefolium By Dr. Ryan Drum
https://naturespiritherbs.com/environmental-origins-of-thyroid-disease-part-1/
106. TIROIDE sotto controllo: il POTERE dei FUNGHI MEDICINALI ! Dr. Ivo Bianchi
https://www.youtube.com/watch?v=Ylhh988ybxY
107. Soffri di TIROIDITE di HASHIMOTO? Ecco come i FUNGHI MEDICINALI possono aiutarti! Dr. Ivo Bianchi
https://www.youtube.com/watch?v=MtTFFWndsWo
108. Reishi – The vital mushroom of millennial life December 13, 2021 Dr. Dorothee Bös et al
https://www.mykotroph.de/en/reishi/
109. American Botanical Council, Specific Indications: Herbs for Endocrine Conditions
http://abc.herbalgram.org/site/DocServer/HerbalFormulariesV3_excerpt_54-59.pdf;jsessionid=00000000.app20116a?docID=9683&NONCE_TOKEN=6A48839F46C17061616D174E05E609CE
110. He T, Zhao R, Lu Y, Li W, Hou X, Sun Y, Dong M, Chen L. Dual-Directional Immunomodulatory Effects of Corbrin Capsule on Autoimmune Thyroid Diseases. Evid Based Complement Alternat Med. 2016;2016:1360386. doi: 10.1155/2016/1360386. Epub 2016 Sep 18. PMID: 27721890; PMCID: PMC5045992.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5045992/
111. Exploring the Uses of the Top Medicinal Mushrooms, 04/04/2023, SCHOOL OF GRADUATE STUDIES Universiti Putra Malaysia, 43400 UPM Serdang ,Selangor
https://sgs.upm.edu.my/article/exploring_the_uses_of_the_top_medicinal_mushrooms-71534
Χοληστερόλη
16. What are the risks from taking statins? Ask the doctor February 1, 2025 By Christopher P. Cannon, MD, Editor in Chief, Harvard Heart Letter; Editorial Advisory Board Member, Harvard Health Publishing
https://www.health.harvard.edu/heart-health/what-are-the-risks-from-taking-statins
17. Statin side effects: Weigh the benefits and risks, By Mayo Clinic Staff
https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statin-side-effects/art-20046013
18. June 16, 2021 CARDIOVASCULAR Some Statins Appear to Increase Dementia in Patients With Mild Cognitive Issues, US Pharmacist
https://www.uspharmacist.com/article/some-statins-appear-to-increase-dementia-in-patients-with-mild-cognitive-issues
19. Do Statins Increase or Decrease Alzheimer’s Risk? James M. Ellison, MD, MPH, Geriatric Psychiatrist, Swank Center for Memory Care and Geriatric Consultation, ChristianaCare, Feb 9, 2024, BrightFocus Foundation
https://www.brightfocus.org/resource/do-statins-increase-or-decrease-alzheimers-risk/
20. Which statin is associated with the lowest risk of myalgia? September 29, 2015, new york state department of health
https://nypep.nysdoh.suny.edu/wp-content/uploads/2021/09/DIRC_SUNY_statins-and-myalgia_v2_9.29.15-fin.pdf
21. Stroes ES, Thompson PD, Corsini A, Vladutiu GD, Raal FJ, Ray KK, Roden M, Stein E, Tokgözoğlu L, Nordestgaard BG, Bruckert E, De Backer G, Krauss RM, Laufs U, Santos RD, Hegele RA, Hovingh GK, Leiter LA, Mach F, März W, Newman CB, Wiklund O, Jacobson TA, Catapano AL, Chapman MJ, Ginsberg HN; European Atherosclerosis Society Consensus Panel. Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Aetiology and Management. Eur Heart J. 2015 May 1;36(17):1012-22. doi: 10.1093/eurheartj/ehv043. Epub 2015 Feb 18. PMID: 25694464; PMCID: PMC4416140.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4416140/
22. Leaf A. Dietary prevention of coronary heart disease: the Lyon Diet Heart Study. Circulation. 1999 Feb 16;99(6):733-5. doi: 10.1161/01.cir.99.6.733. PMID: 9989956.
https://www.ahajournals.org/doi/10.1161/01.cir.99.6.733
23. About Cholesterol, May 15, 2024, CDC of USA
https://www.cdc.gov/cholesterol/about/index.html
24. What Your Cholesterol Levels Mean, American Heart Association, Feb 16, 2024
https://www.heart.org/en/health-topics/cholesterol/about-cholesterol/what-your-cholesterol-levels-mean
Αιματοκρίτης
454. hematocrit, National Cancer Institute at the National Institutes of Health
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/hematocrit
455. Mondal H, Zubair M. Hematocrit. [Updated 2024 Oct 6]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK542276/
456. Billett HH. Hemoglobin and Hematocrit. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Boston: Butterworths; 1990. Chapter 151.
https://www.ncbi.nlm.nih.gov/books/NBK259/
457. Turner J, Parsi M, Badireddy M. Anemia. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK499994/
458. F.G. Huffman, S. Nath, Z.C. Shah, ANEMIA (ANAEMIA) | Other Nutritional Causes, Editor(s): Benjamin Caballero, Encyclopedia of Food Sciences and Nutrition (Second Edition), Academic Press, 2003, Pages 226-232, ISBN 9780122270550, https://doi.org/10.1016/B0-12-227055-X/00043-2.
https://www.sciencedirect.com/topics/veterinary-science-and-veterinary-medicine/nutritional-anemia
459. Killeen RB, Kaur A, Afzal M. Acute Anemia. [Updated 2025 Feb 26]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537232/
460. Stevens GA, Paciorek CJ, Flores-Urrutia MC, Borghi E, Namaste S, Wirth JP, Suchdev PS, Ezzati M, Rohner F, Flaxman SR, Rogers LM. National, regional, and global estimates of anaemia by severity in women and children for 2000-19: a pooled analysis of population-representative data. Lancet Glob Health. 2022 May;10(5):e627-e639. doi: 10.1016/S2214-109X(22)00084-5. PMID: 35427520; PMCID: PMC9023869.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9023869/
461. Malenica M, Prnjavorac B, Bego T, Dujic T, Semiz S, Skrbo S, Gusic A, Hadzic A, Causevic A. Effect of Cigarette Smoking on Haematological Parameters in Healthy Population. Med Arch. 2017 Apr;71(2):132-136. doi: 10.5455/medarh.2017.71.132-136. PMID: 28790546; PMCID: PMC5511531.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5511531/
462. Vitak T, Yurkiv B, Wasser S, Nevo E, Sybirna N. Effect of medicinal mushrooms on blood cells under conditions of diabetes mellitus. World J Diabetes. 2017 May 15;8(5):187-201. doi: 10.4239/wjd.v8.i5.187. PMID: 28572880; PMCID: PMC5437617.
https://pubmed.ncbi.nlm.nih.gov/28572880/
463. Teja KS, Suruchi, Rai U, Kumar M, Mohanty O, Roy J, Meshram S. Mushrooms: A Potential Option in the Management of Deficiency and Diseases in Humans. J Pure Appl Microbiol. 2023;17(2):749-760. doi: 10.22207/JPAM.17.2.55
https://microbiologyjournal.org/mushrooms-a-potential-option-in-the-management-of-deficiency-and-diseases-in-humans/
Ακμή
406. Cordain L, Lindeberg S, Hurtado M, Hill K, Eaton SB, Brand-Miller J. Acne vulgaris: a disease of Western civilization. Arch Dermatol. 2002 Dec;138(12):1584-90. doi: 10.1001/archderm.138.12.1584. PMID: 12472346.
https://pubmed.ncbi.nlm.nih.gov/12472346/
407. Matsui MS. Update on diet and acne. Cutis. 2019 Jul;104(1):11-13. PMID: 31487341.
https://cdn.mdedge.com/files/s3fs-public/CT104001011.PDF
408. J Am Acad Dermatol. 2016 May;74(5):945-73.e33. doi: 10.1016/j.jaad.2015.12.037. Epub 2016 Feb 17. Guidelines of Care for the Management of Acne Vulgaris Andrea L Zaenglein, Arun L Pathy, Bethanee J Schlosser, Ali Alikhan, Hilary E Baldwin, Diane S Berson, Whitney P Bowe, Emmy M Graber, Julie C Harper, Sewon Kang, Jonette E Keri, James J Leyden, Rachel V Reynolds, Nanette B Silverberg, Linda F Stein Gold, Megha M Tollefson, Jonathan S Weiss, Nancy C Dolan, Andrew A Sagan, Mackenzie Stern, Kevin M Boyer, Reva Bhushan
https://pubmed.ncbi.nlm.nih.gov/26897386
409. Am Fam Physician. 2019 Oct 15;100(8):475-484. Acne Vulgaris: Diagnosis and Treatment Linda K Oge', Alan Broussard, Marilyn D Marshall
https://pubmed.ncbi.nlm.nih.gov/31613567
410. Br J Dermatol. 2015 Jul;172 Suppl 1:3-12. doi: 10.1111/bjd.13462. A Global Perspective on the Epidemiology of Acne J K L Tan, K Bhate
https://pubmed.ncbi.nlm.nih.gov/25597339
411. Eur J Dermatol . 2017 Aug 1;27(4):393-398. doi: 10.1684/ejd.2017.3062. Adult Female Acne Treated With Spironolactone: A Retrospective Data Review of 70 Cases Anne Isvy-Joubert, Jean-Michel Nguyen, Aurélie Gaultier, Mélanie Saint-Jean, Marie Le Moigne, Elodie Boisrobert, Amir Khammari, Brigitte Dreno
https://pubmed.ncbi.nlm.nih.gov/28862134
412. Acta Derm Venereol . 2013 Nov;93(6):644-9. doi: 10.2340/00015555-1677. Acne: Risk Indicator for Increased Body Mass Index and Insulin Resistance Bodo C Melnik 1 , Swen Malte John, Gerd Plewig
https://pubmed.ncbi.nlm.nih.gov/23975508/
https://www.researchgate.net/publication/256102062_Acne_Risk_Indicator_for_Increased_Body_Mass_Index_and_Insulin_Resistance
413.Cochrane Database Syst Rev. 2018 Nov 24;11(11):CD009435. doi: 10.1002/14651858.CD009435.pub2. Oral Isotretinoin for Acne Caroline S Costa , Ediléia Bagatin, Ana Luiza C Martimbianco, Edina Mk da Silva, Marília M Lúcio, Parker Magin, Rachel Riera
https://pubmed.ncbi.nlm.nih.gov/30484286
414. Am J Clin Dermatol. 2017 Jun;18(3):311-321. doi: 10.1007/s40257-017-0255-3. The Role of Photodynamic Therapy in Acne: An Evidence-Based Review Monica Boen, Joshua Brownell, Priyanka Patel, Maria M Tsoukas
https://pubmed.ncbi.nlm.nih.gov/28276005
415. Wiad Lek. 2018;71(1 pt 2):144-147. Indicators of Phagocytosis in Women With Acne During Comprehensive Treatment That Included Immunotherapy and Probiotics Orysya О Syzon, Marianna О Dashko
https://pubmed.ncbi.nlm.nih.gov/29602922
416. Cochrane Database Syst Rev. 2016 Apr 3;4(4):CD011946. doi: 10.1002/14651858.CD011946.pub2. Interventions for Acne Scars Rania Abdel Hay, Khalid Shalaby, Hesham Zaher, Vanessa Hafez, Ching-Chi Chi, Sandra Dimitri, Ashraf F Nabhan, Alison M Layton
https://pubmed.ncbi.nlm.nih.gov/27038134
417. Wu, Y.; Choi, M.-H.; Li, J.; Yang, H.; Shin, H.-J. Mushroom Cosmetics: The Present and Future. Cosmetics 2016, 3, 22. https://doi.org/10.3390/cosmetics3030022
https://www.mdpi.com/2079-9284/3/3/22
Αθλητισμός
375. Purcell LK; Canadian Paediatric Society, Paediatric Sports and Exercise Medicine Section. Sport nutrition for young athletes. Paediatr Child Health. 2013 Apr;18(4):200-5. doi: 10.1093/pch/18.4.200. PMID: 24421690; PMCID: PMC3805623.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3805623/
376. Maughan RJ, Depiesse F, Geyer H; International Association of Athletics Federations. The use of dietary supplements by athletes. J Sports Sci. 2007;25 Suppl 1:S103-13. doi: 10.1080/02640410701607395. Erratum in: J Sports Sci. 2009 Apr;27(6):667. PMID: 18049988.
https://pubmed.ncbi.nlm.nih.gov/18049988/
377. Yuping Zhu, Gang Song, Molecular origin and biological effects of exercise mimetics, Journal of Exercise Science & Fitness, Volume 22, Issue 1, 2024, Pages 73-85, ISSN 1728-869X, https://doi.org/10.1016/j.jesf.2023.12.002.
https://www.sciencedirect.com/science/article/pii/S1728869X23000643
378. Giacomello, E.; Nicoletti, C.; Canato, M.; Toniolo, L. Exercise Mimetics in Aging: Suggestions from a Systematic Review. Nutrients 2025, 17, 969. https://doi.org/10.3390/nu17060969
https://www.mdpi.com/2072-6643/17/6/969
379. Gubert C, Hannan AJ. Exercise mimetics: harnessing the therapeutic effects of physical activity. Nat Rev Drug Discov. 2021 Nov;20(11):862-879. doi: 10.1038/s41573-021-00217-1. Epub 2021 Jun 8. PMID: 34103713.
https://pubmed.ncbi.nlm.nih.gov/34103713/
380. Vedant Samant, Arati Prabhu, Exercise, exerkines and exercise mimetic drugs: Molecular mechanisms and therapeutics, Life Sciences, Volume 359, 2024, 123225, ISSN 0024-3205, https://doi.org/10.1016/j.lfs.2024.123225.
https://www.sciencedirect.com/science/article/abs/pii/S0024320524008154
381. Li, S. and Laher, I. (2017), Exercise Mimetics: Running Without a Road Map. Clin. Pharmacol. Ther., 101: 188-190. https://doi.org/10.1002/cpt.533
https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.533
382. Cento, A.S., Leigheb, M., Caretti, G. et al. Exercise and Exercise Mimetics for the Treatment of Musculoskeletal Disorders. Curr Osteoporos Rep 20, 249–259 (2022). https://doi.org/10.1007/s11914-022-00739-6
https://link.springer.com/article/10.1007/s11914-022-00739-6
383. Fan W, Evans RM. Exercise Mimetics: Impact on Health and Performance. Cell Metab. 2017 Feb 7;25(2):242-247. doi: 10.1016/j.cmet.2016.10.022. Epub 2016 Nov 23. PMID: 27889389; PMCID: PMC5555683.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5555683/
384. Zhao, R. Exercise mimetics: a novel strategy to combat neuroinflammation and Alzheimer’s disease. J Neuroinflammation 21, 40 (2024). https://doi.org/10.1186/s12974-024-03031-9
https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-024-03031-9
385. Silver MD. Use of ergogenic aids by athletes. J Am Acad Orthop Surg. 2001 Jan-Feb;9(1):61-70. doi: 10.5435/00124635-200101000-00007. PMID: 11174164.
https://pubmed.ncbi.nlm.nih.gov/11174164/
386. Varillas-Delgado, D. Nutritional Status and Ergogenic Aids in Performance During Exercise and Sports. Nutrients 2025, 17, 1224. https://doi.org/10.3390/nu17071224
https://www.mdpi.com/2072-6643/17/7/1224
387. Thein LA, Thein JM, Landry GL. Ergogenic aids. Phys Ther. 1995 May;75(5):426-39. doi: 10.1093/ptj/75.5.426. PMID: 7732086.
https://pubmed.ncbi.nlm.nih.gov/7732086/
388. Institute of Medicine (US) Committee on Military Nutrition Research; Marriott BM, editor. Food Components to Enhance Performance: An Evaluation of Potential Performance-Enhancing Food Components for Operational Rations. Washington (DC): National Academies Press (US); 1994. 12, Food Components That May Optimize Physical Performance: An Overview.
https://www.ncbi.nlm.nih.gov/books/NBK209034/
389. Ketterly J. Sports Medicine: Ergogenic Aids. FP Essent. 2022 Jul;518:23-28. PMID: 35830325.
https://pubmed.ncbi.nlm.nih.gov/35830325/
390. Maughan RJ. Nutritional ergogenic aids and exercise performance. Nutr Res Rev. 1999 Dec;12(2):255-80. doi: 10.1079/095442299108728956. PMID: 19087454.
https://pubmed.ncbi.nlm.nih.gov/19087454/
391. Wickham KA, Spriet LL. Food for thought: Physiological considerations for nutritional ergogenic efficacy. Scand J Med Sci Sports. 2024; 34:e14307. doi:10.1111/sms.14307
https://onlinelibrary.wiley.com/doi/10.1111/sms.14307
392. Ahrendt DM. Ergogenic aids: counseling the athlete. Am Fam Physician. 2001 Mar 1;63(5):913-22. PMID: 11261867.
https://www.aafp.org/pubs/afp/issues/2001/0301/p913.html
393. Chelladurai, Packianathan. (2008). Athletics IS Education: A Response to Kane, Leo, and Holleran’s (2008) Case Study of University of Minnesota Student-Athletes. Journal of Intercollegiate Sport. 1. 130-138. 10.1123/jis.1.1.130.
https://www.researchgate.net/publication/306054098_Athletics_IS_Education_A_Response_to_Kane_Leo_and_Holleran's_2008_Case_Study_of_University_of_Minnesota_Student-Athletes
394. Forbes SC, Best R and Dominguez R (2024) Editorial: Dietary supplements and ergogenic aids in relation to health and performance. Front. Sports Act. Living 6:1450604. doi: 10.3389/fspor.2024.1450604
https://www.frontiersin.org/journals/sports-and-active-living/articles/10.3389/fspor.2024.1450604/full
395. Dunn J, Grider MH. Physiology, Adenosine Triphosphate. [Updated 2023 Feb 13]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK553175/
https://www.ncbi.nlm.nih.gov/books/NBK553175/
396. Ralf Jäger, Martin Purpura, John A. Rathmacher, John C. Fuller, Lisa M. Pitchford, Fabricio E. Rossi, Chad M. Kerksick, Health and ergogenic potential of oral adenosine-5′-triphosphate (ATP) supplementation, Journal of Functional Foods, Volume 78, 2021, 104357, ISSN 1756-4646, https://doi.org/10.1016/j.jff.2021.104357.
https://www.sciencedirect.com/science/article/pii/S1756464621000062
397. Morgan A. O'Brien, Derek G. Power, A. James P. Clover, Brian Bird, Declan M. Soden, Patrick F. Forde, Local tumour ablative therapies: Opportunities for maximising immune engagement and activation, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Volume 1846, Issue 2, 2014, Pages 510-523, ISSN 0304-419X, https://doi.org/10.1016/j.bbcan.2014.09.005.
https://www.sciencedirect.com/science/article/pii/S0304419X14000870
398. Greiner, J.V.; Glonek, T. Adenosine Triphosphate (ATP) and Protein Aggregation in Age-Related Vision-Threatening Ocular Diseases. Metabolites 2023, 13, 1100. https://doi.org/10.3390/metabo13101100
https://www.mdpi.com/2218-1989/13/10/1100
399. Jensen J, Rustad PI, Kolnes AJ, Lai YC. The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise. Front Physiol. 2011 Dec 30;2:112. doi: 10.3389/fphys.2011.00112. PMID: 22232606; PMCID: PMC3248697.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3248697/
400. Knuiman, P., Hopman, M.T.E. & Mensink, M. Glycogen availability and skeletal muscle adaptations with endurance and resistance exercise. Nutr Metab (Lond) 12, 59 (2015). https://doi.org/10.1186/s12986-015-0055-9
https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-015-0055-9
401. Iliana López-Soldado, Joan J. Guinovart, Jordi Duran, Increased liver glycogen levels enhance exercise capacity in mice, Journal of Biological Chemistry, Volume 297, Issue 2, 2021, 100976, ISSN 0021-9258, https://doi.org/10.1016/j.jbc.2021.100976.
https://www.sciencedirect.com/science/article/pii/S002192582100778X
402. Ørtenblad N, Westerblad H, Nielsen J. Muscle glycogen stores and fatigue. J Physiol. 2013 Sep 15;591(18):4405-13. doi: 10.1113/jphysiol.2013.251629. Epub 2013 May 7. PMID: 23652590; PMCID: PMC3784189.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3784189/
403. Yun-tao Ma, CHAPTER 5 - Overtraining Syndrome and the Use of Muscle in Exercise, Editor(s): Yun-tao Ma, Acupuncture for Sports and Trauma Rehabilitation, Churchill Livingstone, 2011, Pages 36-48, ISBN 9781437709278, https://doi.org/10.1016/B978-1-4377-0927-8.00005-1.
https://www.sciencedirect.com/topics/immunology-and-microbiology/muscle-fatigue
404. W.W. Hay, GROWTH AND DEVELOPMENT, PHYSIOLOGICAL ASPECTS, Editor(s): Benjamin Caballero, Encyclopedia of Human Nutrition (Second Edition), Elsevier, 2005, Pages 423-433, ISBN 9780122266942, https://doi.org/10.1016/B0-12-226694-3/00156-3.
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/glycogen-liver-level
405. Glycogen, Last reviewed on 07/13/2022. Cleveland Clinic
https://my.clevelandclinic.org/health/articles/23509-glycogen
494. Thiebaud, Robert. (2012). Exercise-Induced Muscle Damage: Is it detrimental or beneficial?. Journal of Trainology. 1. 36-44. 10.17338/trainology.1.2_36.
https://www.jstage.jst.go.jp/article/trainology/1/2/1_36/_article
495. Owens DJ, Twist C, Cobley JN, Howatson G, Close GL. Exercise-induced muscle damage: What is it, what causes it and what are the nutritional solutions? Eur J Sport Sci. 2019 Feb;19(1):71-85. doi: 10.1080/17461391.2018.1505957. Epub 2018 Aug 15. PMID: 30110239.
https://pubmed.ncbi.nlm.nih.gov/30110239/
496. Howatson G, van Someren KA. The prevention and treatment of exercise-induced muscle damage. Sports Med. 2008;38(6):483-503. doi: 10.2165/00007256-200838060-00004. PMID: 18489195.
https://pubmed.ncbi.nlm.nih.gov/18489195/
497. Harty, P.S., Cottet, M.L., Malloy, J.K. et al. Nutritional and Supplementation Strategies to Prevent and Attenuate Exercise-Induced Muscle Damage: a Brief Review. Sports Med - Open 5, 1 (2019). https://doi.org/10.1186/s40798-018-0176-6
https://sportsmedicine-open.springeropen.com/articles/10.1186/s40798-018-0176-6.
498. Leite, C.D.F.C.; Zovico, P.V.C.; Rica, R.L.; Barros, B.M.; Machado, A.F.; Evangelista, A.L.; Leite, R.D.; Barauna, V.G.; Maia, A.F.; Bocalini, D.S. Exercise-Induced Muscle Damage after a High-Intensity Interval Exercise Session: Systematic Review. Int. J. Environ. Res. Public Health 2023, 20, 7082. https://doi.org/10.3390/ijerph20227082
https://www.mdpi.com/1660-4601/20/22/7082
499. Sunbol, Khalid & Althiyabi, Fahad & Alshuria, Abdulaziz & Alajwad, Mahdi & Mahlawi, Amoudi & Alsayed, Budur & Alsarhan, Mustafa & Alshehri, Rahaf & Alsahli, Abdulaziz & Alhazmi, Khalid & Esmae, Emtenan. (2022). Etiology, risk factors and complications of exercise induced muscle injury. International Journal Of Community Medicine And Public Health. 10. 10.18203/2394-6040.ijcmph20223319.
https://www.researchgate.net/publication/366387424_Etiology_risk_factors_and_complications_of_exercise_induced_muscle_injury
500. Price TB, Krishnan-Sarin S, Rothman DL. Smoking impairs muscle recovery from exercise. Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E116-22. doi: 10.1152/ajpendo.00543.2002. Epub 2003 Mar 11. PMID: 12637259.
https://pubmed.ncbi.nlm.nih.gov/12637259/
501. İpekoğlu, Gökhan & Taskin, Halil & Şenel, Ömer. (2019). Examination of Exercise-Induced Skeletal and Cardiac Muscle Damage in Terms of Smoking. Montenegrin Journal of Sports Science & Medicine. 8. 10.26773/mjssm.190901.
https://www.researchgate.net/publication/332111862_Examination_of_Exercise-Induced_Skeletal_and_Cardiac_Muscle_Damage_in_Terms_of_Smoking
502. Xu, F.; Zeng, J.; Liu, X.; Lai, J.; Xu, J. Exercise-Induced Muscle Damage and Protein Intake: A Bibliometric and Visual Analysis. Nutrients 2022, 14, 4288. https://doi.org/10.3390/nu14204288
https://www.mdpi.com/2072-6643/14/20/4288
593. Cabaniss CD. Creatine Kinase. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Boston: Butterworths; 1990. Chapter 32.
https://www.ncbi.nlm.nih.gov/books/NBK352/https://www.ncbi.nlm.nih.gov/books/NBK352/
594. Brian R. Berridge, John F. Van Vleet, Eugene Herman, Chapter 46 - Cardiac, Vascular, and Skeletal Muscle Systems, Editor(s): Wanda M. Haschek, Colin G. Rousseaux, Matthew A. Wallig, Haschek and Rousseaux's Handbook of Toxicologic Pathology (Third Edition), Academic Press, 2013, Pages 1567-1665, ISBN 9780124157590, https://doi.org/10.1016/B978-0-12-415759-0.00046-7.
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/creatine-kinase
595. Moghadam-Kia S, Oddis CV, Aggarwal R. Approach to asymptomatic creatine kinase elevation. Cleve Clin J Med. 2016 Jan;83(1):37-42. doi: 10.3949/ccjm.83a.14120. PMID: 26760521; PMCID: PMC4871266.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4871266/
596. David S. Younger, Chapter 19 - Childhood muscular dystrophies, Editor(s): David S. Younger, Handbook of Clinical Neurology, Elsevier, Volume 195, 2023, Pages 461-496, ISSN 0072-9752, ISBN 9780323988186, https://doi.org/10.1016/B978-0-323-98818-6.00024-8.
https://www.sciencedirect.com/topics/nursing-and-health-professions/creatine-kinase-blood-level
597. Laurence A. Bindoff, CHAPTER 33 - Muscle disease, Editor(s): William J. Marshall, Marta Lapsley, Andrew P. Day, Ruth M. Ayling, Clinical Biochemistry: Metabolic and Clinical Aspects (Third Edition), Churchill Livingstone, 2014, Pages 646-659, ISBN 9780702051401, https://doi.org/10.1016/B978-0-7020-5140-1.00033-X.
https://www.sciencedirect.com/topics/nursing-and-health-professions/creatine-kinase-mm
598. Al-Naseem A, Sallam A, Choudhury S, Thachil J. Iron deficiency without anaemia: a diagnosis that matters. Clin Med (Lond). 2021 Mar;21(2):107-113. doi: 10.7861/clinmed.2020-0582. PMID: 33762368; PMCID: PMC8002799.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8002799/
599. Dufaux B, Hoederath A, Streitberger I, Hollmann W, Assmann G. Serum ferritin, transferrin, haptoglobin, and iron in middle- and long-distance runners, elite rowers, and professional racing cyclists. Int J Sports Med. 1981 Feb;2(1):43-6. doi: 10.1055/s-2008-1034583. PMID: 7333734.
https://pubmed.ncbi.nlm.nih.gov/7333734/
600. Nachtigall D, Nielsen P, Fischer R, Engelhardt R, Gabbe EE. Iron deficiency in distance runners. A reinvestigation using Fe-labelling and non-invasive liver iron quantification. Int J Sports Med. 1996 Oct;17(7):473-9. doi: 10.1055/s-2007-972881. PMID: 8912060.
https://pubmed.ncbi.nlm.nih.gov/8912060/
601. Dickson DN, Wilkinson RL, Noakes TD. Effects of ultra-marathon training and racing on hematologic parameters and serum ferritin levels in well-trained athletes. Int J Sports Med. 1982 May;3(2):111-7. doi: 10.1055/s-2008-1026073. PMID: 7107103.
https://pubmed.ncbi.nlm.nih.gov/7107103/
602. Stanzione JR, Bell G, Greenwood DA. A systematic nutrition intervention for low iron status in collegiate distance runners. Nutr Health. 2022 May 9:2601060221100337. doi: 10.1177/02601060221100337. Epub ahead of print. PMID: 35532088.
https://pubmed.ncbi.nlm.nih.gov/35532088/
603. Lai T-F, Liao Y, Hsueh M-C, Yen H-Y, Park J-H and Chang JH (2022) Substituting sedentary time with physical activity in youngest-old to oldest-old community-dwelling older adults: Associations with body composition. Front. Public Health 10:837213. doi: 10.3389/fpubh.2022.837213
https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2022.837213/full
604. Huang Z, Liu Y, Zhou Y. Sedentary Behaviors and Health Outcomes among Young Adults: A Systematic Review of Longitudinal Studies. Healthcare (Basel). 2022 Aug 6;10(8):1480. doi: 10.3390/healthcare10081480. PMID: 36011137; PMCID: PMC9408295.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9408295/
605. Bouamra M, Zouhal H, Ratel S, Makhlouf I, Bezrati I, Chtara M, Behm DG, Granacher U and Chaouachi A (2022) Concurrent Training Promotes Greater Gains on Body Composition and Components of Physical Fitness Than Single-Mode Training (Endurance or Resistance) in Youth With Obesity. Front. Physiol. 13:869063. doi: 10.3389/fphys.2022.869063
https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.869063/full
606. W.Clark Hersey, James E. Graves, Michael L. Pollock, Ronald Gingerich, Rachel B. Shireman, Gregory W. Heath, Francis Spierto, Steve D. McCole, James M. Hagberg, Endurance exercise training improves body composition and plasma insulin responses in 70- to 79-year-old men and women, Metabolism, Volume 43, Issue 7, 1994, Pages 847-854, ISSN 0026-0495, https://doi.org/10.1016/0026-0495(94)90265-8.
https://www.sciencedirect.com/science/article/abs/pii/0026049594902658
607. Júdice PB, Hetherington-Rauth M, Magalhães JP, Correia IR, Sardinha LB. Sedentary behaviours and their relationship with body composition of athletes. Eur J Sport Sci. 2022 Mar;22(3):474-480. doi: 10.1080/17461391.2021.1874060. Epub 2021 Feb 2. PMID: 33416024.
https://pubmed.ncbi.nlm.nih.gov/33416024/
608. SEPTEMBER 28, 2022 High-intensity workouts can help you get fit fast, but preparation is key By Cultivating Health, UC Davis Health
https://health.ucdavis.edu/blog/cultivating-health/high-intensity-workouts-can-help-you-get-fit-fast-but-preparation-is-key/2022/09
609. Verbrugghe J, Agten A, Stevens S, Hansen D, Demoulin C, Eijnde BO, Vandenabeele F, Timmermans A. High Intensity Training to Treat Chronic Nonspecific Low Back Pain: Effectiveness of Various Exercise Modes. J Clin Med. 2020 Jul 27;9(8):2401. doi: 10.3390/jcm9082401. PMID: 32727108; PMCID: PMC7465397.
https://pubmed.ncbi.nlm.nih.gov/32727108/
Ε1. Cordyceps Sinensis, Canadian Academy of Sports Nutrition
https://www.caasn.com/cordyceps-sinensis.html
Ε2. Geng P, Siu KC, Wang Z, Wu JY. Antifatigue Functions and Mechanisms of Edible and Medicinal Mushrooms. Biomed Res Int. 2017;2017:9648496. doi: 10.1155/2017/9648496. Epub 2017 Aug 14. PMID: 28890898; PMCID: PMC5584359.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584359/
Ε3. Nagata, Akira & Tajima, Taeko & Uchida, Masayuki. (2006). Supplemental anti-fatigue effects of Cordyceps sinensis (Tochu-Kaso) extract powder during three stepwise exercise of human. Japanese Journal of Physical Fitness and Sports Medicine. 55. S145-S152. 10.7600/jspfsm.55.S145.
https://www.semanticscholar.org/paper/SUPPLEMENTAL-ANTI-FATIGUE-EFFECTS-OF-CORDYCEPS-OF-Nagata-Tajima/89969d5885d2b9054560ac6edbda023c28844133
https://www.jstage.jst.go.jp/article/jspfsm/55/Supplement/55_S145/_article
Ε4. Yi, Xiao & Xi-zhen, Huang & Zhu, Jia-Shi. (2004). Randomized double-blind placebo-controlled clinical trial and assessment of fermentation product of Cordyceps sinensis (Cs4) in enhancing aerobic capacity and respiratory function of the healthy elderly volunteers. Chinese Journal of Integrative Medicine - CHIN J INTEGR MED. 10. 187-192. 10.1007/BF02836405.
https://link.springer.com/article/10.1007/BF02836405
https://www.researchgate.net/publication/246146225_Randomized_double-blind_placebo-controlled_clinical_trial_and_assessment_of_fermentation_product_of_Cordyceps_sinensis_Cs4_in_enhancing_aerobic_capacity_and_respiratory_function_of_the_healthy_elderly
Ε5. Applegate EA, Grivetti LE. Search for the competitive edge: a history of dietary fads and supplements. J Nutr. 1997 May;127(5 Suppl):869S-873S. doi: 10.1093/jn/127.5.869S. PMID: 9164254.
https://www.sciencedirect.com/science/article/pii/S0022316622074314
Ε6. Gunes-Bayir A, Çemberci M (2023) A review of ergogenic nutritional supplements for athletes. Arch Sports Med Physiother 8(1): 003-010. DOI: 10.17352/asmp.000017
https://www.peertechzpublications.org/articles/ASMP-8-117.php
Ε7. Chen S, Li Z, Krochmal R, Abrazado M, Kim W, Cooper CB. Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trial. J Altern Complement Med. 2010 May;16(5):585-90. doi: 10.1089/acm.2009.0226. PMID: 20804368; PMCID: PMC3110835.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110835/
Ε8. Savioli, Fellipe & Zogaib, Paulo & Franco, Eduardo & Salles, Fernando & Giorelli, Guilherme & Andreoli, Carlos. (2022). Effects of Cordyceps Sinensis Supplementation during 12 weeks in amateur marathoners: a randomized, double-blind placebo-controlled trial. Journal of Herbal Medicine. 34. 100570. 10.1016/j.hermed.2022.100570.
https://www.sciencedirect.com/science/article/abs/pii/S2210803322000392
Ε9. Hirsch KR, Smith-Ryan AE, Roelofs EJ, Trexler ET, Mock MG. Cordyceps militaris Improves Tolerance to High-Intensity Exercise After Acute and Chronic Supplementation. J Diet Suppl. 2017 Jan 2;14(1):42-53. doi: 10.1080/19390211.2016.1203386. Epub 2016 Jul 13. PMID: 27408987; PMCID: PMC5236007.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5236007/
Ε10. Kumar R, Negi PS, Singh B, Ilavazhagan G, Bhargava K, Sethy NK. Cordyceps sinensis promotes exercise endurance capacity of rats by activating skeletal muscle metabolic regulators. J Ethnopharmacol. 2011 Jun 14;136(1):260-6. doi: 10.1016/j.jep.2011.04.040. Epub 2011 Apr 28. PMID: 21549819.
https://pubmed.ncbi.nlm.nih.gov/21549819/
Ε11. Gubert C, Hannan AJ. Exercise mimetics: harnessing the therapeutic effects of physical activity. Nat Rev Drug Discov. 2021 Nov;20(11):862-879. doi: 10.1038/s41573-021-00217-1. Epub 2021 Jun 8. PMID: 34103713.
Ε12. Wenjuan Yan, Taihui Li, Jinghui Lao, Bin Song & Yaheng Shen (2013) Anti-fatigue property of Cordyceps guangdongensis and the underlying mechanisms, Pharmaceutical Biology, 51:5, 614-620, DOI: 10.3109/13880209.2012.760103
https://www.tandfonline.com/doi/full/10.3109/13880209.2012.760103
https://pubmed.ncbi.nlm.nih.gov/34103713/
Ε13. Mycology News, Volume 1, Edition 6, MARCH 2002
https://www.mycologyresearch.com/articles/view/61
Ε14. Ashar, Hardik D. & Panda, Vandana & Semalty, Ajay & Asrani, Kirtika & Semalty, Mona. (2012). Herbal Drugs in Chronic Fatigue Syndrome: An Overview. Swiss Journal of Integrative Medicine. 24. 10.1159/000339011.
https://karger.com/szg/article-pdf/24/3/155/3560240/000339011.pdf
Ε15. Zhang W, Xu L, Yuan M. Clinical studies of several well-known and valuable herbal medicines: a narrative review. Longhua Chin Med 2022;5:5.
https://lcm.amegroups.org/article/view/8106/html
Ε16. Jędrejko, K.J.; Lazur, J.; Muszyńska, B. Cordyceps militaris: An Overview of Its Chemical Constituents in Relation to Biological Activity. Foods 2021, 10, 2634. https://doi.org/10.3390/foods10112634
https://www.mdpi.com/2304-8158/10/11/2634
Ε17. Chinese mushroom remedy found to boost fitness 19 Apr, 2004 06:04 AM,
https://www.nzherald.co.nz/world/chinese-mushroom-remedy-found-to-boost-fitness/CU332AQCL5PVC3G6CUQJSQ42XI/?c_id=2&objectid=3561385
Ε18. H βίβλος της μέγιστης απόδοσης του Δρ. Earl Mindell Ph.D.
https://www.amazon.com/Earl-Mindells-Peak-Performance-Bible-ebook/dp/B000FC0NS2/ref=sr_1_1?ie=UTF8&qid=undefined&sr=8-1&keywords=Dr+Earl+Mindell%27s+peak+performance+bible
Ε19. Στα Ίχνη του Αρχαίου Κόρντισεπς στο σύγχρονο κόσμο, John Holliday, Matt Cleaver
Ε20.Chen CY, Hou CW, Bernard JR, Chen CC, Hung TC, Cheng LL, Liao YH, Kuo CH. Rhodiola crenulata- and Cordyceps sinensis-based supplement boosts aerobic exercise performance after short-term high altitude training. High Alt Med Biol. 2014 Sep;15(3):371-9. doi: 10.1089/ham.2013.1114. PMID: 25251930; PMCID: PMC4174424.
https://pubmed.ncbi.nlm.nih.gov/25251930/
Ε21. Rossi P, Buonocore D, Altobelli E, Brandalise F, Cesaroni V, Iozzi D, Savino E, Marzatico F. Improving Training Condition Assessment in Endurance Cyclists: Effects of Ganoderma lucidum and Ophiocordyceps sinensis Dietary Supplementation. Evid Based Complement Alternat Med. 2014;2014:979613. doi: 10.1155/2014/979613. Epub 2014 Apr 1. PMID: 24799948; PMCID: PMC3995149.
https://pubmed.ncbi.nlm.nih.gov/24799948/
