ΝΕΥΡΑΛΓΙΑ ΤΡΙΔΥΜΟΥ
Σκλήρυνση κατά πλάκας
1. Khaboushan AS, Maroufi SF, Jarrah N, Moafi M, Sabahi M, Borghei-Razavi H, Sheehan JP. Comparison of stereotactic radiosurgery and rhizotomy for trigeminal neuralgia: A systematic review and Meta-Analysis. Neurosurg Rev. 2025 Aug 20;48(1):613. doi: 10.1007/s10143-025-03763-z. PMID: 40833460; PMCID: PMC12368101.
https://pubmed.ncbi.nlm.nih.gov/40833460/

2. Nascimento RFV, Pipek LZ, de Aguiar PHP. Is percutaneous balloon compression better than microvascular decompression to treat trigeminal neuralgia? A systematic review and meta-analysis. J Clin Neurosci. 2023 Mar;109:11-20. doi: 10.1016/j.jocn.2023.01.002. Epub 2023 Jan 10. PMID: 36634472.
https://pubmed.ncbi.nlm.nih.gov/36634472/

3. Ali SMS, Shafique MA, Mustafa MS, Jafri SAA, Khalil S, Fatima H, Rangwala HS. Effectiveness of gamma knife radiosurgery in the management of trigeminal neuralgia associated with multiple sclerosis: a systematic review and meta-analysis. Neurosurg Rev. 2023 Dec 13;47(1):12. doi: 10.1007/s10143-023-02246-3. PMID: 38091115.
https://pubmed.ncbi.nlm.nih.gov/38091115/

4. Penchev P, Milanova-Ilieva D, Gaydarski L, Reghunathan K, Petrov PP, Stanchev P, Ketev K, Husain N. Microsurgical Resection vs Stereotactic Radiosurgery for Secondary Trigeminal Neuralgia Caused by Cerebellopontine Angle Tumors: A Systematic Review and Meta-Analysis with Meta-Regression. Neurosurg Rev. 2025 Aug 8;48(1):596. doi: 10.1007/s10143-025-03750-4. PMID: 40779001.
https://pubmed.ncbi.nlm.nih.gov/40779001/

5. Foley PL, Vesterinen HM, Laird BJ, Sena ES, Colvin LA, Chandran S, MacLeod MR, Fallon MT. Prevalence and natural history of pain in adults with multiple sclerosis: systematic review and meta-analysis. Pain. 2013 May;154(5):632-642. doi: 10.1016/j.pain.2012.12.002. Epub 2012 Dec 14. PMID: 23318126.
https://pubmed.ncbi.nlm.nih.gov/23318126/

6. Texakalidis P, Xenos D, Karras CL, Rosenow JM. Percutaneous Surgical Approaches in Multiple Sclerosis-Related Trigeminal Neuralgia: A Systematic Review and Meta-analysis. World Neurosurg. 2021 Feb;146:342-350.e1. doi: 10.1016/j.wneu.2020.11.006. Epub 2020 Nov 7. PMID: 33171325.
https://pubmed.ncbi.nlm.nih.gov/33171325/

7. Houshi S, Tavallaei MJ, Barzegar M, Afshari-Safavi A, Vaheb S, Mirmosayyeb O, Shaygannejad V. Prevalence of trigeminal neuralgia in multiple sclerosis: A systematic review and meta-analysis. Mult Scler Relat Disord. 2022 Jan;57:103472. doi: 10.1016/j.msard.2021.103472. Epub 2021 Dec 29. PMID: 34986455.
https://pubmed.ncbi.nlm.nih.gov/34986455/

8. Spina A, Nocera G, Boari N, Iannaccone S, Mortini P. Efficacy of Gamma Knife radiosurgery in the management of multiple sclerosis-related trigeminal neuralgia: a systematic review and meta-analysis. Neurosurg Rev. 2021 Dec;44(6):3069-3077. doi: 10.1007/s10143-021-01507-3. Epub 2021 Feb 20. PMID: 33611721.
https://pubmed.ncbi.nlm.nih.gov/33611721/

9. Hajikarimloo B, Tos SM, Mohammadzadeh I, Mortezaei A, Hasanzade A, Najari D, Ebrahimi A, Habibi MA. Efficacy and safety of microvascular decompression in trigeminal neuralgia secondary to multiple sclerosis: a systematic review and meta-analysis. Acta Neurol Belg. 2025 Oct 13. doi: 10.1007/s13760-025-02909-6. Epub ahead of print. PMID: 41082162.
https://pubmed.ncbi.nlm.nih.gov/41082162/

10. SohrabiAsl M, Shirani M, Jahanbakhshi A, Iranmehr A. Efficacy and Challenges: Minimally Invasive Procedures for Trigeminal Neuralgia Treatment in Multiple Sclerosis - A Systematic Review and Meta-Analysis. Stereotact Funct Neurosurg. 2024;102(3):156-168. doi: 10.1159/000538516. Epub 2024 Apr 22. PMID: 38648730.
https://pubmed.ncbi.nlm.nih.gov/38648730/

11. Montano N, Papacci F, Cioni B, Di Bonaventura R, Meglio M. What is the best treatment of drug-resistant trigeminal neuralgia in patients affected by multiple sclerosis? A literature analysis of surgical procedures. Clin Neurol Neurosurg. 2013 May;115(5):567-72. doi: 10.1016/j.clineuro.2012.07.011. Epub 2012 Jul 26. PMID: 22840414.
https://pubmed.ncbi.nlm.nih.gov/22840414/

12. Al Johani K, Fudah M, Al-Zahrani M, Abed H, Srivastava KC, Shrivastava D, Cicciù M, Minervini G. Multiple Sclerosis-A Demyelinating Disorder and Its Dental Considerations-A Literature Review with Own Case Report. Brain Sci. 2023 Jun 29;13(7):1009. doi: 10.3390/brainsci13071009. PMID: 37508941; PMCID: PMC10377366.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10377366/

13. Shkodina AD, Bardhan M, Chopra H, Anyagwa OE, Pinchuk VA, Hryn KV, Kryvchun AM, Boiko DI, Suresh V, Verma A, Delva MY. Pharmacological and Non-pharmacological Approaches for the Management of Neuropathic Pain in Multiple Sclerosis. CNS Drugs. 2024 Mar;38(3):205-224. doi: 10.1007/s40263-024-01072-5. Epub 2024 Feb 29. PMID: 38421578.
https://pubmed.ncbi.nlm.nih.gov/38421578/

14. Al Johani K, Fudah M, Al-Zahrani M, Abed H, Srivastava KC, Shrivastava D, Cicciù M, Minervini G. Multiple Sclerosis-A Demyelinating Disorder and Its Dental Considerations-A Literature Review with Own Case Report. Brain Sci. 2023 Jun 29;13(7):1009. doi: 10.3390/brainsci13071009. PMID: 37508941; PMCID: PMC10377366.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10377366/

15. All about trigeminal neuralgia, The Ottawa Hospital Foundation
https://ohfoundation.ca/all-about-trigeminal-neuralgia/

16. Medical Causes of Facial Pain Part II      Published April 26, 2022, The Facial Pain Association
https://www.facepain.org/blog/medical-causes-of-facial-painpart-ii/

17. Lassmann H. Multiple Sclerosis Pathology. Cold Spring Harb Perspect Med. 2018 Mar 1;8(3):a028936. doi: 10.1101/cshperspect.a028936. PMID: 29358320; PMCID: PMC5830904.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5830904/

18. Fallata A, Salter A, Tyry T, Cutter GR, Marrie RA. Trigeminal Neuralgia Commonly Precedes the Diagnosis of Multiple Sclerosis. Int J MS Care. 2017 Sep-Oct;19(5):240-246. doi: 10.7224/1537-2073.2016-065. PMID: 29070964; PMCID: PMC5649347.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5649347/

19. Nova, Andrea & Fazia, Teresa & Di Caprio, Giovanni & Gentilini, Davide & Bernardinelli, Luisa & Bergamaschi, Roberto. (2025). Timing and Predictive Value of Clinical Conditions Preceding Multiple Sclerosis in the UK Biobank. Annals of Clinical and Translational Neurology. 12. 1952-1961. 10.1002/acn3.70119.
https://www.researchgate.net/publication/393070622_Timing_and_Predictive_Value_of_Clinical_Conditions_Preceding_Multiple_Sclerosis_in_the_UK_Biobank

20. Al Johani K, Fudah M, Al-Zahrani M, Abed H, Srivastava KC, Shrivastava D, Cicciù M, Minervini G. Multiple Sclerosis-A Demyelinating Disorder and Its Dental Considerations-A Literature Review with Own Case Report. Brain Sci. 2023 Jun 29;13(7):1009. doi: 10.3390/brainsci13071009. PMID: 37508941; PMCID: PMC10377366.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10377366/

21. Multiple Sclerosis in Dental Considerations, Scholarly community Encyclopedia
https://encyclopedia.pub/entry/46590

22. Chapter: Medical Surgical Nursing: Management of Patients With Neurologic Infections, Autoimmune Disorders, and Neuropathies Trigeminal Neuralgia (Tic Douloureux) - Cranial Nerve Disorders, BrainKart.com
https://www.brainkart.com/article/Trigeminal-Neuralgia-(Tic-Douloureux)---Cranial-Nerve-Disorders_32532/

23. Racke MK, Frohman EM, Frohman T. Pain in Multiple Sclerosis: Understanding Pathophysiology, Diagnosis, and Management Through Clinical Vignettes. Front Neurol. 2022 Jan 13;12:799698. doi: 10.3389/fneur.2021.799698. PMID: 35095742; PMCID: PMC8794582.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8794582/

24. Trigeminal Neuralgia and MS: How Gamma Knife Can Help, Dr. Anthony D’Ambrosio, M.D., M.B.A., F.A.A.N.S, Valley Health System
https://www.valleygammaknife.com/trigeminal-neuralgia-and-ms/

25. Trigeminal Neuralgia, Dr. Christopher Honey,
https://drhoney.org/tn/

26. MS and Trigeminal Neuralgia: Is There a Link? Written by Kara Mayer Robinson Medically Reviewed by Christopher Melinosky, MD on December 12, 2024
https://www.webmd.com/multiple-sclerosis/ms-trigeminal-neuralgia

27. Trigeminal neuralgia, Multiple Sclerosis Trust
https://mstrust.org.uk/a-z/trigeminal-neuralgia

28. The Painful Tooth: My Weekend of Agony John Connor avatar  by John Connor | July 30, 2021,
https://multiplesclerosisnewstoday.com/columns/2021/07/28trigeminal-neuralgia-painful-tooth-my-weekend-agony/

29. Are Trigeminal Neuralgia and MS Related? Medically reviewed by Amit M. Shelat, D.O. Written by Sarah Winfrey Posted on May 17, 2022
https://www.mymsteam.com/resources/are-trigeminal-neuralgia-and-ms-related

30. Redekop, W., & Hooge, J. (1995). Trigeminal neuralgia in multiple sclerosis. Neurology, 45(7), 1294–1296.
https://www.ovid.com/journals/neur/abstract/00006114-199507000-00011~trigeminal-neuralgia-in-multiple-sclerosis

31. Jensen TS, Rasmussen P, Reske-Nielsen E. Association of trigeminal neuralgia with multiple sclerosis: clinical and pathological features. Acta Neurol Scand. 1982 Mar;65(3):182-9. doi: 10.1111/j.1600-0404.1982.tb03076.x. PMID: 7080803.
https://pubmed.ncbi.nlm.nih.gov/7080803/

32. Trigeminal neuralgia in a patient with multiple sclerosis     Friedman, Charles E.     Journal of Endodontics, Volume 15, Issue 8, 379 - 380
https://www.jendodon.com/article/S0099-2399(89)80077-9/abstract

33. Yates TJ, Crawley F. Paroxysmal symptoms in multiple sclerosis masquerading as transient ischaemic attacks. BMJ Case Rep. 2010 Jul 23;2010:bcr0320102831. doi: 10.1136/bcr.03.2010.2831. PMID: 22767624; PMCID: PMC3029382.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3029382/

34. Trigeminal Neuralgia: An Early Multiple Sclerosis Symptom December 2, 2015, Dental Asia
https://dentalasia.net/trigeminal-neuralgia-an-early-multiple-sclerosis-symptom/

35. Joanna M. Zakrzewska, Jianhua Wu, Tricia S.-L. Brathwaite, A Systematic Review of the Management of Trigeminal Neuralgia in Patients with Multiple Sclerosis, World Neurosurgery, Volume 111, 2018, Pages 291-306, ISSN 1878-8750, https://doi.org/10.1016/j.wneu.2017.12.147.
https://www.sciencedirect.com/science/article/abs/pii/S1878875017322635

36. Godazandeh, Kimia & Martinez Sosa, Santiago & Wu, Jianhua & Zakrzewska, Joanna. (2019). Trigeminal neuralgia: Comparison of characteristics and impact in patients with or without multiple sclerosis. Multiple Sclerosis and Related Disorders. 34. 10.1016/j.msard.2019.06.015.
https://www.researchgate.net/publication/7816011_A_clinical_comparison_of_trigeminal_neuralgic_pain_in_patients_with_and_without_underlying_multiple_sclerosis

37. Ganesan, K., Thomson, A. (2021). Trigeminal Neuralgia. In: Bonanthaya, K., Panneerselvam, E., Manuel, S., Kumar, V.V., Rai, A. (eds) Oral and Maxillofacial Surgery for the Clinician. Springer, Singapore. https://doi.org/10.1007/978-981-15-1346-6_26
https://link.springer.com/chapter/10.1007/978-981-15-1346-6_26

38. Laakso, Sini & Oh, Jiwon & Raufdeen, Fasna & Jones, Ashley & Reiskanen, Henri & Feb, Ken & Levit, Elle & Solomon, Andrew. (2024). Trigeminal neuralgia within the disease course of MS: Diagnostic and therapeutic implications from a multicenter cohort. Multiple Sclerosis Journal. 31. 607-611. 10.1177/13524585241309257.
https://www.researchgate.net/publication/387475166_Trigeminal_neuralgia_within_the_disease_course_of_MS_Diagnostic_and_therapeutic_implications_from_a_multicenter_cohort

39. April 7, 2025 Free Access Trigeminal Neuralgia in Multiple Sclerosis: Characteristics and Healthcare Utilization in the State of Florida (P12-1.016) Freddy Escobar-Montealegre, Elsa Rodriguez, Laura Snider, Danielle Tupes, Mayra Montalvo Perero, and Torge Rempe
https://www.neurology.org/doi/10.1212/WNL.0000000000212335

40. Armocida, Daniele. “Multiple Sclerosis and Trigeminal Neuralgia: A Well-Noted Association with Unknown Occurrence as a Presenting Symptom: Our Experience in Multi Centric Study.” (2020).
https://iris.uniroma1.it/retrieve/738522e8-5509-40f8-8aea-642834dff183/OAJBS.ID.000145.pdf

41. Burkholder DB, Koehler PJ, Boes CJ. Trigeminal Neuralgia and Multiple Sclerosis: A Historical Perspective. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques. 2017;44(5):589-593. doi:10.1017/cjn.2017.196
https://www.cambridge.org/core/journals/canadian-journal-of-neurological-sciences/article/trigeminal-neuralgia-and-multiple-sclerosis-a-historical-perspective/0A8A067471FB40153243335D8BF760E9

42. M. Alan Stiles, James Evans, chapter 46 - Trigeminal Neuralgia, Editor(s): Steven D. Waldman, Joseph I. Bloch, Pain Management, W.B. Saunders, 2007, Pages 502-510, ISBN 9780721603346, https://doi.org/10.1016/B978-0-7216-0334-6.50050-9.
https://www.sciencedirect.com/topics/nursing-and-health-professions/trigeminus-neuralgia

43. Trigeminal neuralgia, type of nerve pain, is an early multiple sclerosis symptom, Dec 01,201
https://www.mscare.org/trigeminal-neuralgia-type-of-nerve-pain-is-an-early-multiple-sclerosis-symptom/

44. The Connection Between Multiple Sclerosis and Trigeminal Neuralgia, Dr. Kashouty, Premier Neurology & Wellness Center
https://premierneurologycenter.com/blog/the-connection-between-multiple-sclerosis-and-trigeminal-neuralgia/

Έρπης
1. Alfaifi AJ, Wasli OS, Almalki TM, Alqassim AY. Trigeminal Neuralgia Secondary to Herpes Simplex Virus Type 1 Infection Treated With Oral Acyclovir. Cureus. 2024 Feb 13;16(2):e54128. doi: 10.7759/cureus.54128. PMID: 38487110; PMCID: PMC10939157.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10939157/

2. Niemeyer, C.S., Harlander-Locke, M., Bubak, A.N. et al. Trigeminal Postherpetic Neuralgia: From Pathophysiology to Treatment. Curr Pain Headache Rep 28, 295–306 (2024). https://doi.org/10.1007/s11916-023-01209-z
https://link.springer.com/article/10.1007/s11916-023-01209-z

3. Umehara T, Oka H, Toyoda C, Mochio S. Pearls and oy-sters: trigeminal neuropathy associated with herpes labialis. Neurology. 2012 Nov 6;79(19):e173-5. doi: 10.1212/WNL.0b013e3182735c3d. PMID: 23128446.
https://www.neurology.org/doi/10.1212/WNL.0b013e3182735c3d

4. Yao Xiao, Can Wang, Jianmin Dong, Ximing Zhang, Yuehong Wu, Zhiyou Peng, Yunfei Cao, Case Report of Secondary Trigeminal Neuralgia Following Nerve Block-Induced Herpes Zoster Infection, Pain Management Nursing, 2025, , ISSN 1524-9042, https://doi.org/10.1016/j.pmn.2025.07.002.
https://www.sciencedirect.com/science/article/abs/pii/S1524904225002279

5. Red Butte PainSolutions,  Shingles Pain and Trigeminal Neuralgia Relief  by Red Butte Pain Solutions | Jul 27, 2025 | Nerve Pain, Post Herpetic Neuralgia, Shingles
https://redbuttepain.com/shingles-pain-trigeminal-neuralgia-relief/

6.  Piradov М.A., Maksimova M.Y., Sineva N.A. Trigeminal neuralgia associated with herpes zoster // Annals of Clinical and Experimental Neurology. - 2017. - Vol. 11. - N. 1. - P. 62-67. doi: 10.17816/ACEN.2017.1.6165
https://annaly-nevrologii.com/pathID/article/view/461

7. Feller L, Khammissa RAG, Fourie J, Bouckaert M, Lemmer J. Postherpetic Neuralgia and Trigeminal Neuralgia. Pain Res Treat. 2017;2017:1681765. doi: 10.1155/2017/1681765. Epub 2017 Dec 5. PMID: 29359044; PMCID: PMC5735631.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5735631/

8. Malik U, Malik S D, Srivastava C. Trigeminal Herpes Zoster: A Brief Review.J Skin Stem Cell.2022;8(4):e122036.https://doi.org/10.5812/jssc.122036.
https://brieflands.com/journals/jssc/articles/122036

Αυτοάνοσα
1. Maikap D, Padhan P. Trigeminal Neuralgia as an Initial Presentation of Systemic Autoimmune Diseases: A Case Series. Mediterr J Rheumatol. 2022 Sep 30;33(3):333-338. doi: 10.31138/mjr.33.3.333. PMID: 36531419; PMCID: PMC9727472.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9727472/

2. Jeemon, G., Neha, T.H. Mixed connective tissue disease: presenting as trigeminal neuralgia. Egypt J Intern Med 34, 48 (2022). https://doi.org/10.1186/s43162-022-00137-5
https://link.springer.com/article/10.1186/s43162-022-00137-5

3. Kumar V, Kaur J, Pothuri P, Bandagi S. Atypical Trigeminal Neuralgia: A Rare Neurological Manifestation of Systemic Lupus Erythematosus. Am J Case Rep. 2017 Jan 12;18:42-45. doi: 10.12659/ajcr.901478. PMID: 28077839; PMCID: PMC5240879.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5240879/

4. Medical Causes of Facial Pain, April 28, 2021, The Facial Pain Association
https://www.facepain.org/blog/medical-causes-of-facial-pain/

5. Neurologic Complications,    Johns Hopkins Rheumatology,
https://www.hopkinssjogrens.org/disease-information/sjogrens-disease/neurologic-complications/

6. Jiaxin Yuan, Li Gong, Hongliang Wu, Qi Chen, Jiahui Wang, Weiyi Chen, Xiaotong Wang, Chao Ren, Case report of primary Sjögren Syndrome with simple trigeminal lesion as initial symptom, Journal of Neuroimmunology, Volume 324, 2018, Pages 126-128, ISSN 0165-5728, https://doi.org/10.1016/j.jneuroim.2018.08.005.
https://www.sciencedirect.com/science/article/abs/pii/S0165572818303849

7. Maltez N, Choi MY, Troyanov Y, Wang M, Jantz M, Fritzler MJ, Baron M, Hudson M; Canadian Scleroderma Research Group. Trigeminal neuralgia in systemic sclerosis. Semin Arthritis Rheum. 2021 Feb;51(1):318-323. doi: 10.1016/j.semarthrit.2021.01.001. Epub 2021 Jan 7. PMID: 33461050.
https://pubmed.ncbi.nlm.nih.gov/33461050/

8. Talbot J, Patel R, Gormley J 010 Trigeminal neuralgia in diffuse scleroderma – a rare but recognised association Journal of Neurology, Neurosurgery & Psychiatry 2022;93:e2
https://jnnp.bmj.com/content/93/9/e2.202

9. Scleroderma Education Program Chapter 3 Pain and Fatigue, Johns Hopkins Rheumatology
https://www.hopkinsscleroderma.org/wp-content/uploads/2010/01/scleroderma_ed3.pdf

Άγχος
14. Anxiety Disorders, National Institute of Mental Health December 2024
https://www.nimh.nih.gov/health/topics/anxiety-disorders

15. Chand SP, Marwaha R. Anxiety. [Updated 2023 Apr 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-.
https://www.ncbi.nlm.nih.gov/books/NBK470361/

16. Bonanno, M.; Papa, D.; Cerasa, A.; Maggio, M.G.; Calabrò, R.S. Psycho-Neuroendocrinology in the Rehabilitation Field: Focus on the Complex Interplay between Stress and Pain. Medicina 2024, 60, 285. https://doi.org/10.3390/medicina60020285
https://www.mdpi.com/1648-9144/60/2/285

17. Aboushaar N and Serrano N (2024) The mutually reinforcing dynamics between pain and stress: mechanisms, impacts and management strategies. Front. Pain Res. 5:1445280. doi: 10.3389/fpain.2024.1445280
https://www.frontiersin.org/journals/pain-research/articles/10.3389/fpain.2024.1445280/full

18. Xiao Yu, Mathieu Nollet, Nicholas P. Franks, William Wisden, Sleep and the recovery from stress, Neuron, Volume 113, Issue 18, 2025, Pages 2910-2926, ISSN 0896-6273, https://doi.org/10.1016/j.neuron.2025.04.028.
https://www.sciencedirect.com/science/article/pii/S0896627325003113

19. Haack M, Simpson N, Sethna N, Kaur S, Mullington J. Sleep deficiency and chronic pain: potential underlying mechanisms and clinical implications. Neuropsychopharmacology. 2020 Jan;45(1):205-216. doi: 10.1038/s41386-019-0439-z. Epub 2019 Jun 17. PMID: 31207606; PMCID: PMC6879497.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6879497/

20. Staffe AT, Bech MW, Clemmensen SLK, Nielsen HT, Larsen DB, Petersen KK. Total sleep deprivation increases pain sensitivity, impairs conditioned pain modulation and facilitates temporal summation of pain in healthy participants. PLoS One. 2019 Dec 4;14(12):e0225849. doi: 10.1371/journal.pone.0225849. PMID: 31800612; PMCID: PMC6892491.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6892491/

21. Maydych V. The Interplay Between Stress, Inflammation, and Emotional Attention: Relevance for Depression. Front Neurosci. 2019 Apr 24;13:384. doi: 10.3389/fnins.2019.00384. PMID: 31068783; PMCID: PMC6491771.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6491771/

22. Fang XX, Zhai MN, Zhu M, He C, Wang H, Wang J, Zhang ZJ. Inflammation in pathogenesis of chronic pain: Foe and friend. Mol Pain. 2023 Jan-Dec;19:17448069231178176. doi: 10.1177/17448069231178176. PMID: 37220667; PMCID: PMC10214073.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10214073/

23. Lv SS, Lv XJ, Cai YQ, et al. Corticotropin-releasing hormone neurons control trigeminal neuralgia-induced anxiodepression via a hippocampus-to-prefrontal circuit. Science Advances. 2024 Jan;10(3):eadj4196. DOI: 10.1126/sciadv.adj4196. PMID: 38241377; PMCID: PMC10798562.
https://europepmc.org/article/MED/38241377

24. Spina A, Mortini P, Alemanno F, Houdayer E, Iannaccone S. Trigeminal Neuralgia: Toward a Multimodal Approach. World Neurosurg. 2017 Jul;103:220-230. doi: 10.1016/j.wneu.2017.03.126. Epub 2017 Apr 2. PMID: 28377244.
https://pubmed.ncbi.nlm.nih.gov/28377244/

25.  Luo N, Li R, Wang Y, et al. Effectiveness and safety of acupuncture for treating trigeminal neuralgia associated anxiety and depression: A protocol for systematic review and meta-analysis. Medicine. 2022 Jan;101(3):e28631. DOI: 10.1097/md.0000000000028631. PMID: 35060545; PMCID: PMC8772693.
https://europepmc.org/article/MED/35060545

26. Trigeminal Neuralgia, Brigham and Women's Hospital
https://healthlibrary.brighamandwomens.org/134,66

27. Depression and chronic pain Posted on July 19, 2020, Dr. Jaydev Panchwagh ,
https://trigeminalneuralgiatreatment.org/tag/anxiety-and-pain/

28. Mačianskytė D, Janužis G, Kubilius R, Adomaitienė V, Ščiupokas A. Associations between chronic pain and depressive symptoms in patients with trigeminal neuralgia. Medicina (Kaunas). 2011;47(7):386-92. PMID: 22112988.
https://pubmed.ncbi.nlm.nih.gov/22112988

29. Chang B, Zhu W, Li S. Effects of Depression and Anxiety on Microvascular Decompression Outcome for Trigeminal Neuralgia Patients. World Neurosurg. 2019 Aug;128:e556-e561. doi: 10.1016/j.wneu.2019.04.194. Epub 2019 May 6. PMID: 31071444.
https://www.sciencedirect.com/science/article/abs/pii/S1878875019311891

30. Melek LN, Devine M, Renton T. The psychosocial impact of orofacial pain in trigeminal neuralgia patients: a systematic review. Int J Oral Maxillofac Surg. 2018 Jul;47(7):869-878. doi: 10.1016/j.ijom.2018.02.006. Epub 2018 Mar 8. PMID: 29526561.
https://pubmed.ncbi.nlm.nih.gov/29526561/

Ιδιοπαθής
2. Zakrzewska, Joanna M., and Stine Maarbjerg, 'Classical and idiopathic trigeminal neuralgia', in Joanna M. Zakrzewska, and Turo Nurmikko (eds), Trigeminal Neuralgia and Other Cranial Neuralgias: A Practical Personalised Holistic Approach, Oxford Pain Management Library (Oxford, 2021; online edn, Oxford Academic, 1 Apr. 2022), https://doi.org/10.1093/med/9780198871606.003.0007, accessed 10 Dec. 2025.
https://academic.oup.com/book/41275/chapter-abstract/351444377?redirectedFrom=fulltext

3. Jiao, Xw. (1984). Idiopathic Trigeminal Neuralgia. In: Wu, Hg., Ran, Rt. (eds) Modern Chinese Medicine Volume 1 Chinese Surgery. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5598-1_16
https://link.springer.com/chapter/10.1007/978-94-009-5598-1_16

4. Gerwin, R. Chronic Facial Pain: Trigeminal Neuralgia, Persistent Idiopathic Facial Pain, and Myofascial Pain Syndrome—An Evidence-Based Narrative Review and Etiological Hypothesis. Int. J. Environ. Res. Public Health 2020, 17, 7012. https://doi.org/10.3390/ijerph17197012
https://www.mdpi.com/1660-4601/17/19/7012

5. Familial occurrence of classical and idiopathic trigeminal neuralgia     Eide, Per Kristian     Journal of the Neurological Sciences, Volume 434, 120101
https://www.jns-journal.com/article/S0022-510X(21)02803-3/fulltext

6. Obermann M, Holle D, Katsarava Z. Trigeminal neuralgia and persistent idiopathic facial pain. Expert Rev Neurother. 2011 Nov;11(11):1619-29. doi: 10.1586/ern.11.156. PMID: 22014140.
https://pubmed.ncbi.nlm.nih.gov/22014140/


7. Causes - Trigeminal neuralgia, NHS UK, 27 January 2023
https://www.nhs.uk/conditions/trigeminal-neuralgia/causes/

Εγκυμοσύνη
1. Swain BP, Vidhya S, Jadon A, Chandra KN, Kumar S. Trigeminal Neuralgia in Pregnancy: A Management Challenge. Pain Pract. 2018 Mar;18(3):368-373. doi: 10.1111/papr.12605. Epub 2017 Jul 6. PMID: 28574640.
https://pubmed.ncbi.nlm.nih.gov/28574640/

2. Swain, B.P. (2019). Management of Trigeminal Neuralgia During Pregnancy. In: Rath, G. (eds) Handbook of Trigeminal Neuralgia. Springer, Singapore. https://doi.org/10.1007/978-981-13-2333-1_29
https://link.springer.com/chapter/10.1007/978-981-13-2333-1_29

3. Saravia AC, Gupta S, Tripti K. Management of a case of trigeminal neuralgia in pregnancy with radiofrequency ablation of the nerve [Internet]. Indian J Obstet Gynecol Res. 2024 [cited 2025 Dec 03];11(1):116-118. Available from: https://doi.org/10.18231/j.ijogr.2024.023
https://ijogr.org/archive/volume/11/issue/1/article/13650

4. Trigeminal Neuralgia During Pregnancy, cloudninecare hospitals
https://www.cloudninecare.com/blog/trigeminal-neuralgia-during-pregnancy

Κληρονομικότητα
1. Gupta, V.; Singh, A.K.; Kumar, S.; Sinha, S.. Familial Trigeminal Neuralgia. Neurology India 50(1):p 87-89, Jan–Mar 2002.
https://journals.lww.com/neur/fulltext/2002/50010/familial_trigeminal_neuralgia.20.aspx

2. Trigeminal Neuralgia, Yale University
https://www.yalemedicine.org/conditions/trigeminal-neuralgia

3. Fernández Rodríguez B, Simonet C, Cerdán DM, Morollón N, Guerrero P, Tabernero C, et al. Neuralgia del trigémino clásica familiar. Neurología. 2019;34:229–233.
https://www.elsevier.es/en-revista-neurologia-english-edition--495-articulo-familial-classic-trigeminal-neuralgia-S2173580818301792

4. Mannerak MA, Lashkarivand A, Eide PK. Trigeminal neuralgia and genetics: A systematic review. Mol Pain. 2021 Jan-Dec;17:17448069211016139. doi: 10.1177/17448069211016139. PMID: 34000891; PMCID: PMC8135221.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8135221/

5. Per Kristian Eide, Familial occurrence of classical and idiopathic trigeminal neuralgia, Journal of the Neurological Sciences, Volume 434, 2022, 120101, ISSN 0022-510X, https://doi.org/10.1016/j.jns.2021.120101.
https://www.sciencedirect.com/science/article/pii/S0022510X21028033

Θάνατος
1. Zakrzewska JM. Surgical management of trigeminal neuralgia. Br Dent J. 1991 Jan 19;170(2):61-2. doi: 10.1038/sj.bdj.4807418. PMID: 2001317.
https://pubmed.ncbi.nlm.nih.gov/2001317/

2. Rughani AI, Dumont TM, Lin CT, Tranmer BI, Horgan MA. Safety of microvascular decompression for trigeminal neuralgia in the elderly. Clinical article. J Neurosurg. 2011 Aug;115(2):202-9. doi: 10.3171/2011.4.JNS101924. Epub 2011 May 13. PMID: 21568658.
https://pubmed.ncbi.nlm.nih.gov/21568658/

3. Barker FG 2nd, Jannetta PJ, Bissonette DJ, Larkins MV, Jho HD. The long-term outcome of microvascular decompression for trigeminal neuralgia. N Engl J Med. 1996 Apr 25;334(17):1077-83. doi: 10.1056/NEJM199604253341701. PMID: 8598865.
https://pubmed.ncbi.nlm.nih.gov/8598865/

4. Resnick DK, Jannetta PJ, Bissonnette D, Jho HD, Lanzino G. Microvascular decompression for glossopharyngeal neuralgia. Neurosurgery. 1995 Jan;36(1):64-8; discussion 68-9. doi: 10.1227/00006123-199501000-00008. PMID: 7708170.
https://pubmed.ncbi.nlm.nih.gov/7708170/

5. Guo X, Fu W, Zhang G, Liang Q, Li Z, Li W, Ma X. Standard operating procedure and surgical technique innovation in fully endoscopic microvascular decompression for trigeminal neuralgia: technical note on 189 patients. Acta Neurochir (Wien). 2024 Aug 26;166(1):351. doi: 10.1007/s00701-024-06244-2. PMID: 39186137.
https://pubmed.ncbi.nlm.nih.gov/39186137/

6. Sun J, Wang J, Jia J, Cao Z, Li Z, Zhang C, Guo X, Wu Q, Li W, Ma X. Fully Endoscopic Microvascular Decompression for Trigeminal Neuralgia Caused by Vertebrobasilar Artery: A Case Series Review: 2-Dimensional Operative Video. Oper Neurosurg. 2024 Apr 1;26(4):433-441. doi: 10.1227/ons.0000000000000998. Epub 2023 Nov 17. PMID: 37976445; PMCID: PMC12338293.
https://pubmed.ncbi.nlm.nih.gov/37976445/

7. Zeng YJ, Zhang H, Yu S, Zhang W, Sun XC. Efficacy and Safety of Microvascular Decompression and Gamma Knife Surgery Treatments for Patients with Primary Trigeminal Neuralgia: A Prospective Study. World Neurosurg. 2018 Aug;116:e113-e117. doi: 10.1016/j.wneu.2018.04.120. Epub 2018 Apr 26. PMID: 29705231.
https://pubmed.ncbi.nlm.nih.gov/29705231/

8. Xiang H, Wu G, Ouyang J, Liu R. Prospective Study of Neuroendoscopy versus Microscopy: 213 Cases of Microvascular Decompression for Trigeminal Neuralgia Performed by One Neurosurgeon. World Neurosurg. 2018 Mar;111:e335-e339. doi: 10.1016/j.wneu.2017.12.051. Epub 2017 Dec 16. PMID: 29258938.
https://pubmed.ncbi.nlm.nih.gov/29258938/

9. Kolluri S, Heros RC. Microvascular decompression for trigeminal neuralgia. A five-year follow-up study. Surg Neurol. 1984 Sep;22(3):235-40. doi: 10.1016/0090-3019(84)90005-3. PMID: 6463831.
https://pubmed.ncbi.nlm.nih.gov/6463831/

10. Tomasello F, Cardali MS, Angileri FF, Romano A, La Torre D. Minimally invasive microvascular decompression for trigeminal neuralgia: results and complication avoidance in a consecutive series of patients. Neurosurg Focus. 2025 Sep 1;59(3):E14. doi: 10.3171/2025.6.FOCUS25475. PMID: 40889380.
https://pubmed.ncbi.nlm.nih.gov/40889380/

11. Yu R, Wang C, Qu C, Jiang J, Meng Q, Wang J, Wei S. Study on the Therapeutic Effects of Trigeminal Neuralgia With Microvascular Decompression and Stereotactic Gamma Knife Surgery in the Elderly. J Craniofac Surg. 2019 Jan;30(1):e77-e80. doi: 10.1097/SCS.0000000000004999. PMID: 30507874.
https://pubmed.ncbi.nlm.nih.gov/30507874/

12. Iwanaga J, Clifton W, Dallapiazza RF, Miyamoto Y, Komune N, Gremillion HA, Dumont AS, Tubbs RS. The pterygospinous and pterygoalar ligaments and their relationship to the mandibular nerve: Application to a better understanding of various forms of trigeminal neuralgia. Ann Anat. 2020 May;229:151466. doi: 10.1016/j.aanat.2020.151466. Epub 2020 Jan 20. PMID: 31972273.
https://pubmed.ncbi.nlm.nih.gov/11780888/

13. Shulev YA, Gordienko KS, Trashin AV, Pechiborshch DA. Mikrovaskulyarnaya dekompressiya pri nevralgii troinichnogo nerva vsledstvie vertebrobazilyarnoi dolikhoektazii [Microvascular decompression in trigeminal neuralgia following vertebrobasilar dolichoectasia]. Zh Vopr Neirokhir Im N N Burdenko. 2020;84(5):50-63. Russian. doi: 10.17116/neiro20208405150. PMID: 33095533.
https://pubmed.ncbi.nlm.nih.gov/33095533/

14. Deng S, Luo J, Lai M, Yang W, Feng W, Ouyang J, Kuang J. Percutaneous balloon compression for trigeminal neuralgia: experience and surgical techniques from a single institution. Acta Neurol Belg. 2023 Dec;123(6):2295-2302. doi: 10.1007/s13760-023-02310-1. Epub 2023 Jun 23. PMID: 37353706; PMCID: PMC10682111.
https://pubmed.ncbi.nlm.nih.gov/37353706/

15. Kalkanis SN, Eskandar EN, Carter BS, Barker FG 2nd. Microvascular decompression surgery in the United States, 1996 to 2000: mortality rates, morbidity rates, and the effects of hospital and surgeon volumes. Neurosurgery. 2003 Jun;52(6):1251-61; discussion 1261-2. doi: 10.1227/01.neu.0000065129.25359.ee. PMID: 12762870.
https://pubmed.ncbi.nlm.nih.gov/12762870/

16. Lin KH, Chen YT, Fuh JL, Wang SJ. Increased risk of trigeminal neuralgia in patients with migraine: A nationwide population-based study. Cephalalgia. 2016 Nov;36(13):1218-1227. doi: 10.1177/0333102415623069. Epub 2016 Jul 19. PMID: 26692399.
https://pubmed.ncbi.nlm.nih.gov/26692399/

17. López Chiriboga AS, Cheshire WP Jr. Trigeminal Neuralgia Following Lightning Injury. J Oral Facial Pain Headache. 2017 Fall;31(4):e7-e9. doi: 10.11607/ofph.1871. PMID: 29073666.
https://pubmed.ncbi.nlm.nih.gov/29073666/

18. Bayat M, Bayat A, Blauenfeldt RA. Atypical painful stroke presentations: A review. Acta Neurol Scand. 2022 Nov;146(5):465-474. doi: 10.1111/ane.13666. Epub 2022 Jul 5. PMID: 35788546; PMCID: PMC9796438.
https://pubmed.ncbi.nlm.nih.gov/35788546/

19 .Fishbein NS, Bakhshaie J, Greenberg J. Suicidal Ideation and Self-Injury in Trigeminal Neuralgia. J Pain Res. 2025 Apr 12;18:2003-2010. doi: 10.2147/JPR.S493649. PMID: 40241816; PMCID: PMC12002323.
https://pubmed.ncbi.nlm.nih.gov/40241816/

Αιτία
1. Lazar ML, Kirkpatrick JB. Trigeminal neuralgia and multiple sclerosis: demonstration of the plaque in an operative case. Neurosurgery. 1979 Dec;5(6):711-7. doi: 10.1227/00006123-197912000-00013. PMID: 534082.
https://pubmed.ncbi.nlm.nih.gov/534082/

2. Haller S, Etienne L, Kövari E, Varoquaux AD, Urbach H, Becker M. Imaging of Neurovascular Compression Syndromes: Trigeminal Neuralgia, Hemifacial Spasm, Vestibular Paroxysmia, and Glossopharyngeal Neuralgia. AJNR Am J Neuroradiol. 2016 Aug;37(8):1384-92. doi: 10.3174/ajnr.A4683. Epub 2016 Feb 18. PMID: 26892985; PMCID: PMC7960264.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7960264/

3. Mo J, Zhang J, Hu W, Luo F, Zhang K. Whole-brain morphological alterations associated with trigeminal neuralgia. J Headache Pain. 2021 Aug 13;22(1):95. doi: 10.1186/s10194-021-01308-5. PMID: 34388960; PMCID: PMC8362283.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8362283/

4. Li F, Han S, Ma Y, Yi F, Xu X, Liu Y. Optimal duration of percutaneous microballoon compression for treatment of trigeminal nerve injury. Neural Regen Res. 2014 Jan 15;9(2):179-89. doi: 10.4103/1673-5374.125347. PMID: 25206799; PMCID: PMC4146163.
https://europepmc.org/article/MED/25206799

5. Mousavi SH, Lindsey JW, Westlund KN, Alles SRA. Trigeminal Neuralgia as a Primary Demyelinating Disease: Potential Multimodal Evidence and Remaining Controversies. J Pain. 2024 Feb;25(2):302-311. doi: 10.1016/j.jpain.2023.08.012. Epub 2023 Aug 27. PMID: 37643657.
https://www.sciencedirect.com/science/article/pii/S1526590023005254

6. Wang H, Xia L, Huang Z, Ma Y, Yao G, Hu S, Dou N, Li S, Lian H, Chen K, Zhong J. Suppression of Schwann Cell Ferroptosis Mitigates Demyelination and Trigeminal Neuropathic Pain in the IoN-CCI Model. Eur J Neurosci. 2025 Aug;62(3):e70209. doi: 10.1111/ejn.70209. PMID: 40780703.
https://pubmed.ncbi.nlm.nih.gov/40780703/

7. Wei W, Liu Y, Shen Y, et al. In situ tissue profile of rat trigeminal nerve in trigeminal neuralgia using spatial transcriptome sequencing. International Journal of Surgery (London, England). 2024 Mar;110(3):1463-1474. DOI: 10.1097/js9.0000000000001110. PMID: 38270619; PMCID: PMC10942187.
https://pubmed.ncbi.nlm.nih.gov/38270619/

8. Xia S, Qin X, Wang Y. DMH1-loaded peptide nanomicelles restore myelin and attenuate neuroinflammation in trigeminal neuralgia via CCL5 suppression. Front Pharmacol. 2025 Aug 6;16:1590624. doi: 10.3389/fphar.2025.1590624. PMID: 40843375; PMCID: PMC12364832.
https://pubmed.ncbi.nlm.nih.gov/40843375/

9. Svedung Wettervik T, Folkvaljon D, Gordh T, Freyhult E, Kultima K, Ericson H, Abu Hamdeh S. Cerebrospinal Fluid in Classical Trigeminal Neuralgia: An Exploratory Study on Candidate Biomarkers. Biomedicines. 2022 Apr 26;10(5):998. doi: 10.3390/biomedicines10050998. PMID: 35625736; PMCID: PMC9138315.
https://pubmed.ncbi.nlm.nih.gov/35625736/

10. Ataoglu C, Erginoglu U, Aydin S, Sapanci M, Salamat S, Baskaya MK. A unique presentation of trigeminal neuralgia related to a central nervous tissue choristoma along the trigeminal nerve root: illustrative case. J Neurosurg Case Lessons. 2024 Nov 4;8(19):CASE24384. doi: 10.3171/CASE24384. PMID: 39496159; PMCID: PMC11539290.
https://pubmed.ncbi.nlm.nih.gov/39496159/

11. Ferroli P, Vetrano IG, Acerbi F, Raccuia G, Schiariti M, Confalonieri P, Chiapparini L, Broggi M. Trigeminal interfascicular neurolysis (nerve combing) for refractory recurrent neuralgia in multiple sclerosis. Neurosurg Focus Video. 2020 Oct 1;3(2):V3. doi: 10.3171/2020.5.FOCVID203. PMID: 36285264; PMCID: PMC9542691.
https://pubmed.ncbi.nlm.nih.gov/36285264/

12. Ma F, Zhang L, Westlund KN. Trigeminal nerve injury ErbB3/ErbB2 promotes mechanical hypersensitivity. Anesthesiology. 2012 Aug;117(2):381-8. doi: 10.1097/ALN.0b013e3182604b2b. PMID: 22705569; PMCID: PMC3406246.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3406246/

13. Liao MF, Lee M, Hsieh MJ, Cheng MY, Lee JD, Weng HH, Ro LS. Evaluation of the pathophysiology of classical trigeminal neuralgia by blink reflex study and current perception threshold testing. J Headache Pain. 2010 Jun;11(3):241-6. doi: 10.1007/s10194-010-0198-z. Epub 2010 Feb 26. PMID: 20186560; PMCID: PMC3451913.
https://pubmed.ncbi.nlm.nih.gov/20186560/

14. Love S, Hilton DA, Coakham HB. Central demyelination of the Vth nerve root in trigeminal neuralgia associated with vascular compression. Brain Pathol. 1998 Jan;8(1):1-11; discussion 11-2. doi: 10.1111/j.1750-3639.1998.tb00126.x. PMID: 9458161; PMCID: PMC8098389.
https://pubmed.ncbi.nlm.nih.gov/9458161/

15. Sahoo NK, Thakral A, Deb P, Roy ID. Histopathological Evaluation of Inferior Alveolar Neurovascular Bundle in Cases of Trigeminal Neuralgia. J Maxillofac Oral Surg. 2020 Mar;19(1):54-60. doi: 10.1007/s12663-019-01214-z. Epub 2019 Mar 20. PMID: 31988565; PMCID: PMC6954937.
https://pubmed.ncbi.nlm.nih.gov/31988565/

16. Guan XY, Yuan BT, Li MN, Wang T, Zhu LP, Song SY, Ji LL, Gao YJ, Ma LJ. Promoter demethylation of cerebellin 2 by ten-eleven translocation 3 contributes to peripheral sensitization in trigeminal neuropathic pain of mice. J Headache Pain. 2025 Jul 15;26(1):160. doi: 10.1186/s10194-025-02093-1. PMID: 40665237; PMCID: PMC12261730.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12261730/

17. Hodaie M, Chen DQ, Quan J, Laperriere N. Tractography delineates microstructural changes in the trigeminal nerve after focal radiosurgery for trigeminal neuralgia. PLoS One. 2012;7(3):e32745. doi: 10.1371/journal.pone.0032745. Epub 2012 Mar 6. PMID: 22412918; PMCID: PMC3295766.
https://pubmed.ncbi.nlm.nih.gov/22412918/

18. Türk Börü Ü, Kadir Sarıtaş Z, Görücü Özbek F, Bölük C, Acar H, Koç Y, Zeytin Demiral G. Alterations in the spinal cord, trigeminal nerve ganglion, and infraorbital nerve through inducing compression of the dorsal horn region at the upper cervical cord in trigeminal neuralgia. Brain Res. 2024 Jun 1;1832:148842. doi: 10.1016/j.brainres.2024.148842. Epub 2024 Mar 4. PMID: 38447599.
https://pubmed.ncbi.nlm.nih.gov/38447599/

19. Zhang Y, Mao Z, Cui Z, Ling Z, Pan L, Liu X, Zhang J, Yu X. Diffusion Tensor Imaging of Axonal and Myelin Changes in Classical Trigeminal Neuralgia. World Neurosurg. 2018 Apr;112:e597-e607. doi: 10.1016/j.wneu.2018.01.095. Epub 2018 Feb 2. PMID: 29410338.
https://pubmed.ncbi.nlm.nih.gov/29410338/

20. Filimonova EA, Pashkov AA, Yarnykh VL, Schukina MI, Zaitsev BA, Martirosyan AV, Moysak GI, Rzaev JA. Assessment of Trigeminal Nerve Root Demyelination in Patients with Primary Trigeminal Neuralgia Using Macromolecular Proton Fraction Imaging. AJNR Am J Neuroradiol. 2025 Mar 4;46(3):602-610. doi: 10.3174/ajnr.A8545. PMID: 40016130; PMCID: PMC11979799.
https://pubmed.ncbi.nlm.nih.gov/40016130/

21. Nomura K, Ryu H, Ohno K, Sato K. Varying length of central myelin along the trigeminal nerve might contribute to trigeminal neuralgia. Clin Anat. 2019 May;32(4):541-545. doi: 10.1002/ca.23348. Epub 2019 Feb 16. PMID: 30719770.
https://pubmed.ncbi.nlm.nih.gov/30719770/

22. Obermann M, Yoon MS, Ese D, Maschke M, Kaube H, Diener HC, Katsarava Z. Impaired trigeminal nociceptive processing in patients with trigeminal neuralgia. Neurology. 2007 Aug 28;69(9):835-41. doi: 10.1212/01.wnl.0000269670.30045.6b. PMID: 17724285.
https://pubmed.ncbi.nlm.nih.gov/17724285/

23. De Stefano G, Leone C, Di Pietro G, Esposito N, Falco P, Galosi E, Litewczuk D, Mollica C, Truini A, Di Stefano G. Unravelling the role of unmyelinated nerve fibres in trigeminal neuralgia with concomitant continuous pain. Clin Neurophysiol. 2022 Oct;142:52-58. doi: 10.1016/j.clinph.2022.07.502. Epub 2022 Aug 5. PMID: 35970059.
https://pubmed.ncbi.nlm.nih.gov/35970059/

24. Zeng C, Zhang C, Xiao R, Li Y, Luo X, Deng H, Yang H. Establishment of a Rat Model of Infraorbital Neuroinflammation Under CT Guidance. Curr Neurovasc Res. 2023;20(2):261-269. doi: 10.2174/1567202620666230607113839. PMID: 37287282.
https://pubmed.ncbi.nlm.nih.gov/37287282/

25. Calvin WH, Loeser JD, Howe JF. A neurophysiological theory for the pain mechanism of tic douloureux. Pain. 1977 Apr;3(2):147-154. doi: 10.1016/0304-3959(77)90078-1. PMID: 876672.
https://pubmed.ncbi.nlm.nih.gov/876672/

26. Bocchino JV, Tucker HM. Recurrent laryngeal nerve pathology in spasmodic dysphonia. Laryngoscope. 1978 Aug;88(8 Pt 1):1274-8. doi: 10.1288/00005537-197808000-00008. PMID: 209266.
https://pubmed.ncbi.nlm.nih.gov/209266/

27. Li CMF, Chu PPW, Hung PS, Mikulis D, Hodaie M. Standardizing T1-w/T2-w ratio images in trigeminal neuralgia to estimate the degree of demyelination in vivo. Neuroimage Clin. 2021;32:102798. doi: 10.1016/j.nicl.2021.102798. Epub 2021 Aug 21. PMID: 34450507; PMCID: PMC8391058.
https://pubmed.ncbi.nlm.nih.gov/34450507/

28. Wilcox SL, Gustin SM, Eykman EN, Fowler G, Peck CC, Murray GM, Henderson LA. Trigeminal nerve anatomy in neuropathic and non-neuropathic orofacial pain patients. J Pain. 2013 Aug;14(8):865-72. doi: 10.1016/j.jpain.2013.02.014. Epub 2013 May 17. PMID: 23685183.
https://www.jpain.org/article/S1526-5900(13)00935-8/fulltext

29. Devor M, Govrin-Lippmann R, Rappaport ZH. Mechanism of trigeminal neuralgia: an ultrastructural analysis of trigeminal root specimens obtained during microvascular decompression surgery. J Neurosurg. 2002 Mar;96(3):532-43. doi: 10.3171/jns.2002.96.3.0532. PMID: 11883839.
https://pubmed.ncbi.nlm.nih.gov/11883839/

30. Tanaka BS, Zhao P, Dib-Hajj FB, Morisset V, Tate S, Waxman SG, Dib-Hajj SD. A gain-of-function mutation in Nav1.6 in a case of trigeminal neuralgia. Mol Med. 2016 Sep;22:338-348. doi: 10.2119/molmed.2016.00131. Epub 2016 Aug 3. PMID: 27496104; PMCID: PMC5023517.
https://europepmc.org/article/MED/27496104

31. Liao JY, Zhou TH, Chen BK, Liu ZX. Schwann cells and trigeminal neuralgia. Mol Pain. 2020 Jan-Dec;16:1744806920963809. doi: 10.1177/1744806920963809. PMID: 33054604; PMCID: PMC7786407.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7786407/

32. Pergolizzi JV Jr, LeQuang JA, El-Tallawy SN, Wagner M, Ahmed RS, Varrassi G. An update on pharmacotherapy for trigeminal neuralgia. Expert Rev Neurother. 2024 Aug;24(8):773-786. doi: 10.1080/14737175.2024.2365946. Epub 2024 Jun 13. PMID: 38870050.
https://pubmed.ncbi.nlm.nih.gov/38870050/

33. Suwa H, Hanakita J, Mizuno M, Namura S, Ohtsuka T, Asahi M, Li W, Kondoh A. [Long-term follow up of trigeminal neuralgic patients treated by retrogasserian rhizotomy or by microvascular decompression]. No Shinkei Geka. 1993 Jan;21(1):29-36. Japanese. PMID: 8426685.
https://pubmed.ncbi.nlm.nih.gov/8426685/

34. Nagata K, Matsui T, Joshita H, Shigeno T, Asano T. [Surgical treatment of spasmodic torticollis: effectiveness of microvascular decompression]. No To Shinkei. 1989 Jan;41(1):97-102. Japanese. PMID: 2655675.
https://pubmed.ncbi.nlm.nih.gov/2655675/

35. Love S, Coakham HB. Trigeminal neuralgia: pathology and pathogenesis. Brain. 2001 Dec;124(Pt 12):2347-60. doi: 10.1093/brain/124.12.2347. Erratum in: Brain 2002 Mar;125(Pt 3):687. PMID: 11701590.
https://pubmed.ncbi.nlm.nih.gov/11701590/

36. Rish B. Electromagnetic Induction Aberration: The Possible Mechanism of Tic Douloureux. Cureus. 2015 Mar 10;7(3):e255. doi: 10.7759/cureus.255. PMID: 26180679; PMCID: PMC4494566.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4494566/

37.  Araya EI, Claudino RF, Piovesan EJ, Chichorro JG. Trigeminal Neuralgia: Basic and Clinical Aspects. Current Neuropharmacology. 2020 ;18(2):109-119. DOI: 10.2174/1570159x17666191010094350. PMID: 31608834; PMCID: PMC7324879.
https://europepmc.org/article/MED/31608834

38. BBC, MS trial results suggest drugs could repair damage 27 September 2025 Laura Devlin
https://www.bbc.com/news/articles/crmedvdx8ylo

101. Tanaka BS, Zhao P, Dib-Hajj FB, Morisset V, Tate S, Waxman SG, Dib-Hajj SD. A gain-of-function mutation in Nav1.6 in a case of trigeminal neuralgia. Mol Med. 2016 Sep;22:338-348. doi: 10.2119/molmed.2016.00131. Epub 2016 Aug 3. PMID: 27496104; PMCID: PMC5023517.
https://pmc.ncbi.nlm.nih.gov/articles/PMC5023517/

102. Ataoglu C, Erginoglu U, Aydin S, Sapanci M, Salamat S, Baskaya MK. A unique presentation of trigeminal neuralgia related to a central nervous tissue choristoma along the trigeminal nerve root: illustrative case. J Neurosurg Case Lessons. 2024 Nov 4;8(19):CASE24384. doi: 10.3171/CASE24384. PMID: 39496159; PMCID: PMC11539290.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11539290/

103. Svedung Wettervik T, Folkvaljon D, Gordh T, Freyhult E, Kultima K, Ericson H, Abu Hamdeh S. Cerebrospinal Fluid in Classical Trigeminal Neuralgia: An Exploratory Study on Candidate Biomarkers. Biomedicines. 2022 Apr 26;10(5):998. doi: 10.3390/biomedicines10050998. PMID: 35625736; PMCID: PMC9138315.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9138315/

104. Xia S, Qin X, Wang Y. DMH1-loaded peptide nanomicelles restore myelin and attenuate neuroinflammation in trigeminal neuralgia via CCL5 suppression. Front Pharmacol. 2025 Aug 6;16:1590624. doi: 10.3389/fphar.2025.1590624. PMID: 40843375; PMCID: PMC12364832.
https://pmc.ncbi.nlm.nih.gov/articles/PMC12364832/

105. Sahoo NK, Thakral A, Deb P, Roy ID. Histopathological Evaluation of Inferior Alveolar Neurovascular Bundle in Cases of Trigeminal Neuralgia. J Maxillofac Oral Surg. 2020 Mar;19(1):54-60. doi: 10.1007/s12663-019-01214-z. Epub 2019 Mar 20. PMID: 31988565; PMCID: PMC6954937.
https://pmc.ncbi.nlm.nih.gov/articles/PMC6954937/

106. Wei W, Liu Y, Shen Y, Yang T, Dong Y, Han Z, Wang Y, Liu Z, Chai Y, Zhang M, Wang H, Shen H, Shen Y, Chen M. In situ tissue profile of rat trigeminal nerve in trigeminal neuralgia using spatial transcriptome sequencing. Int J Surg. 2024 Mar 1;110(3):1463-1474. doi: 10.1097/JS9.0000000000001110. PMID: 38270619; PMCID: PMC10942187.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10942187/

107. Quanchareonsap W, Jariyakosol S, Apinyawasisuk S, Roumwong A, Chentanez V. Microanatomy of the central myelin portion and transitional zone of the oculomotor and abducens nerves. Folia Morphol (Warsz). 2023;82(3):543-550. doi: 10.5603/FM.a2022.0057. Epub 2022 Jun 13. PMID: 35692113.
https://journals.viamedica.pl/folia_morphologica/article/view/90133

108. McBenedict B, Goh KS, Yau RCC, Elamin S, Yusuf WH, Verly G, Thomas A, Alphonse B, Ouabicha K, Valentim G, Hauwanga WN, Lima Pessôa B. Neuropathic Pain Secondary to Multiple Sclerosis: A Narrative Review. Cureus. 2024 Jun 3;16(6):e61587. doi: 10.7759/cureus.61587. PMID: 38962595; PMCID: PMC11221503.
https://pmc.ncbi.nlm.nih.gov/articles/PMC11221503/

109. Haller S, Etienne L, Kövari E, Varoquaux AD, Urbach H, Becker M. Imaging of Neurovascular Compression Syndromes: Trigeminal Neuralgia, Hemifacial Spasm, Vestibular Paroxysmia, and Glossopharyngeal Neuralgia. AJNR Am J Neuroradiol. 2016 Aug;37(8):1384-92. doi: 10.3174/ajnr.A4683. Epub 2016 Feb 18. PMID: 26892985; PMCID: PMC7960264.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7960264/

110. Hodaie M, Chen DQ, Quan J, Laperriere N. Tractography delineates microstructural changes in the trigeminal nerve after focal radiosurgery for trigeminal neuralgia. PLoS One. 2012;7(3):e32745. doi: 10.1371/journal.pone.0032745. Epub 2012 Mar 6. PMID: 22412918; PMCID: PMC3295766.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3295766/

111. Liao JY, Zhou TH, Chen BK, Liu ZX. Schwann cells and trigeminal neuralgia. Mol Pain. 2020 Jan-Dec;16:1744806920963809. doi: 10.1177/1744806920963809. PMID: 33054604; PMCID: PMC7786407.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7786407/

112. Ferroli P, Vetrano IG, Acerbi F, Raccuia G, Schiariti M, Confalonieri P, Chiapparini L, Broggi M. Trigeminal interfascicular neurolysis (nerve combing) for refractory recurrent neuralgia in multiple sclerosis. Neurosurg Focus Video. 2020 Oct 1;3(2):V3. doi: 10.3171/2020.5.FOCVID203. PMID: 36285264; PMCID: PMC9542691.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9542691/

113. Wilcox SL, Gustin SM, Eykman EN, Fowler G, Peck CC, Murray GM, Henderson LA. Trigeminal nerve anatomy in neuropathic and non-neuropathic orofacial pain patients. J Pain. 2013 Aug;14(8):865-72. doi: 10.1016/j.jpain.2013.02.014. Epub 2013 May 17. PMID: 23685183.
https://www.jpain.org/article/S1526-5900(13)00935-8/fulltext

114. Mo J, Zhang J, Hu W, Luo F, Zhang K. Whole-brain morphological alterations associated with trigeminal neuralgia. J Headache Pain. 2021 Aug 13;22(1):95. doi: 10.1186/s10194-021-01308-5. PMID: 34388960; PMCID: PMC8362283.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8362283/

115. Rish B. Electromagnetic Induction Aberration: The Possible Mechanism of Tic Douloureux. Cureus. 2015 Mar 10;7(3):e255. doi: 10.7759/cureus.255. PMID: 26180679; PMCID: PMC4494566.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4494566/

116. DaSilva AF, DosSantos MF. The role of sensory fiber demography in trigeminal and postherpetic neuralgias. J Dent Res. 2012 Jan;91(1):17-24. doi: 10.1177/0022034511411300. Epub 2011 Jun 13. PMID: 21670221; PMCID: PMC3232114.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3232114/

117. Liao MF, Lee M, Hsieh MJ, Cheng MY, Lee JD, Weng HH, Ro LS. Evaluation of the pathophysiology of classical trigeminal neuralgia by blink reflex study and current perception threshold testing. J Headache Pain. 2010 Jun;11(3):241-6. doi: 10.1007/s10194-010-0198-z. Epub 2010 Feb 26. PMID: 20186560; PMCID: PMC3451913.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3451913/

118. Li F, Han S, Ma Y, Yi F, Xu X, Liu Y. Optimal duration of percutaneous microballoon compression for treatment of trigeminal nerve injury. Neural Regen Res. 2014 Jan 15;9(2):179-89. doi: 10.4103/1673-5374.125347. PMID: 25206799; PMCID: PMC4146163.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4146163/

119. Love S, Hilton DA, Coakham HB. Central demyelination of the Vth nerve root in trigeminal neuralgia associated with vascular compression. Brain Pathol. 1998 Jan;8(1):1-11; discussion 11-2. doi: 10.1111/j.1750-3639.1998.tb00126.x. PMID: 9458161; PMCID: PMC8098389.
https://pmc.ncbi.nlm.nih.gov/articles/PMC8098389/

120. Ma F, Zhang L, Westlund KN. Trigeminal nerve injury ErbB3/ErbB2 promotes mechanical hypersensitivity. Anesthesiology. 2012 Aug;117(2):381-8. doi: 10.1097/ALN.0b013e3182604b2b. PMID: 22705569; PMCID: PMC3406246.
https://pmc.ncbi.nlm.nih.gov/articles/PMC3406246/

121. Pergolizzi JV Jr, LeQuang JA, El-Tallawy SN, Wagner M, Ahmed RS, Varrassi G. An update on pharmacotherapy for trigeminal neuralgia. Expert Rev Neurother. 2024 Aug;24(8):773-786. doi: 10.1080/14737175.2024.2365946. Epub 2024 Jun 13. PMID: 38870050.
https://pubmed.ncbi.nlm.nih.gov/38870050/

122. Zhang Y, Mao Z, Cui Z, Ling Z, Pan L, Liu X, Zhang J, Yu X. Diffusion Tensor Imaging of Axonal and Myelin Changes in Classical Trigeminal Neuralgia. World Neurosurg. 2018 Apr;112:e597-e607. doi: 10.1016/j.wneu.2018.01.095. Epub 2018 Feb 2. PMID: 29410338.
https://pubmed.ncbi.nlm.nih.gov/29410338/

123. Love S, Coakham HB. Trigeminal neuralgia: pathology and pathogenesis. Brain. 2001 Dec;124(Pt 12):2347-60. doi: 10.1093/brain/124.12.2347. Erratum in: Brain 2002 Mar;125(Pt 3):687. PMID: 11701590.
https://pubmed.ncbi.nlm.nih.gov/11701590/

124. Filimonova EA, Pashkov AA, Yarnykh VL, Schukina MI, Zaitsev BA, Martirosyan AV, Moysak GI, Rzaev JA. Assessment of Trigeminal Nerve Root Demyelination in Patients with Primary Trigeminal Neuralgia Using Macromolecular Proton Fraction Imaging. AJNR Am J Neuroradiol. 2025 Mar 4;46(3):602-610. doi: 10.3174/ajnr.A8545. PMID: 40016130; PMCID: PMC11979799.
https://pubmed.ncbi.nlm.nih.gov/40016130/

125. Samadian M, Bakhtevari MH, Nosari MA, Babadi AJ, Razaei O. Trigeminal Neuralgia Caused by Venous Angioma: A Case Report and Review of the Literature. World Neurosurg. 2015 Sep;84(3):860-4. doi: 10.1016/j.wneu.2015.04.063. Epub 2015 May 9. PMID: 25968963.
https://pubmed.ncbi.nlm.nih.gov/25968963/

126. Gao JJ, Liang T, Wen SL, Feng RQ, Zheng Y, Chen SS, Chen JE, Xu XL. Harnessing polysialic acid (PSA)-embedded exudate-absorbing hydrogel for on-demand trigeminal neuralgia treatment. Int J Biol Macromol. 2025 Jan;284(Pt 1):138035. doi: 10.1016/j.ijbiomac.2024.138035. Epub 2024 Nov 23. PMID: 39586435.
https://pubmed.ncbi.nlm.nih.gov/39586435/

127. Love S, Gradidge T, Coakham HB. Trigeminal neuralgia due to multiple sclerosis: ultrastructural findings in trigeminal rhizotomy specimens. Neuropathol Appl Neurobiol. 2001 Jun;27(3):238-44. doi: 10.1046/j.0305-1846.2001.00318.x. PMID: 11489143.
https://pubmed.ncbi.nlm.nih.gov/11489143/

128. De Stefano G, Leone C, Di Pietro G, Esposito N, Falco P, Galosi E, Litewczuk D, Mollica C, Truini A, Di Stefano G. Unravelling the role of unmyelinated nerve fibres in trigeminal neuralgia with concomitant continuous pain. Clin Neurophysiol. 2022 Oct;142:52-58. doi: 10.1016/j.clinph.2022.07.502. Epub 2022 Aug 5. PMID: 35970059.
https://pubmed.ncbi.nlm.nih.gov/35970059/

129. Obermann M, Yoon MS, Ese D, Maschke M, Kaube H, Diener HC, Katsarava Z. Impaired trigeminal nociceptive processing in patients with trigeminal neuralgia. Neurology. 2007 Aug 28;69(9):835-41. doi: 10.1212/01.wnl.0000269670.30045.6b. PMID: 17724285.
https://pubmed.ncbi.nlm.nih.gov/17724285/

130. Loeser JD, Calvin WH, Howe JF. Pathophysiology of trigeminal neuralgia. Clin Neurosurg. 1977;24:527-37. doi: 10.1093/neurosurgery/24.cn_suppl_1.527. PMID: 583697.
https://pubmed.ncbi.nlm.nih.gov/583697/

131. Devor M, Govrin-Lippmann R, Rappaport ZH. Mechanism of trigeminal neuralgia: an ultrastructural analysis of trigeminal root specimens obtained during microvascular decompression surgery. J Neurosurg. 2002 Mar;96(3):532-43. doi: 10.3171/jns.2002.96.3.0532. PMID: 11883839.
https://pubmed.ncbi.nlm.nih.gov/11883839/

132. Guclu B, Sindou M, Meyronet D, Streichenberger N, Simon E, Mertens P. Cranial nerve vascular compression syndromes of the trigeminal, facial and vago-glossopharyngeal nerves: comparative anatomical study of the central myelin portion and transitional zone; correlations with incidences of corresponding hyperactive dysfunctional syndromes. Acta Neurochir (Wien). 2011 Dec;153(12):2365-75. doi: 10.1007/s00701-011-1168-1. Epub 2011 Sep 27. PMID: 21947457.
https://pubmed.ncbi.nlm.nih.gov/21947457/

133. Phillips DB, Del Bigio MR, Kaufmann AM. Gamma Knife rhizotomy-induced histopathology in multiple sclerosis-related trigeminal neuralgia. J Neurosurg. 2014 Dec;121(6):1508-13. doi: 10.3171/2014.8.JNS131545. Epub 2014 Sep 26. PMID: 25259565.
https://pubmed.ncbi.nlm.nih.gov/25259565/

134. Wang H, Xia L, Huang Z, Ma Y, Yao G, Hu S, Dou N, Li S, Lian H, Chen K, Zhong J. Suppression of Schwann Cell Ferroptosis Mitigates Demyelination and Trigeminal Neuropathic Pain in the IoN-CCI Model. Eur J Neurosci. 2025 Aug;62(3):e70209. doi: 10.1111/ejn.70209. PMID: 40780703.
https://pubmed.ncbi.nlm.nih.gov/40780703/

135.Li R, Chang N, Liu Y, Zhang Y, Luo Y, Zhang T, Zhao Q, Qi X. The Integrity of the Substructure of the Corpus Callosum in Patients With Right Classic Trigeminal Neuralgia. J Craniofac Surg. 2021 Mar-Apr 01;32(2):632-636. doi: 10.1097/SCS.0000000000007082. PMID: 33704998.
https://pubmed.ncbi.nlm.nih.gov/33704998/

136. Rish B. Electromagnetic Induction Aberration: The Possible Mechanism of Tic Douloureux. Cureus. 2015 Mar 10;7(3):e255. doi: 10.7759/cureus.255. PMID: 26180679; PMCID: PMC4494566.
https://pubmed.ncbi.nlm.nih.gov/26180679/

137. Sandell T, Eide PK. The effect of microvascular decompression in patients with multiple sclerosis and trigeminal neuralgia. Neurosurgery. 2010 Sep;67(3):749-53; discussion 753-4. doi: 10.1227/01.NEU.0000375491.81803.5D. PMID: 20651626.
https://pubmed.ncbi.nlm.nih.gov/20651626/

138. Lazar ML, Kirkpatrick JB. Trigeminal neuralgia and multiple sclerosis: demonstration of the plaque in an operative case. Neurosurgery. 1979 Dec;5(6):711-7. doi: 10.1227/00006123-197912000-00013. PMID: 534082.
https://pubmed.ncbi.nlm.nih.gov/534082/

139. Lagares A, Rivas JJ, Jiménez L, Cicuendez M, Avendaño C. Central demyelination in the pathogenesis of trigeminal neuralgia associated with cerebellopontine angle tumors: case report with ultrastructural trigeminal root analysis. Neurosurgery. 2010 Apr;66(4):E841-2. doi: 10.1227/01.NEU.0000367550.30165.A7. PMID: 20190659.
https://pubmed.ncbi.nlm.nih.gov/20190659/

140. Stepanchenko AV. Klinicheskie aspekty nevralgii troĭnichnogo nerva [Clinical aspects of trigeminal neuralgia]. Zh Nevropatol Psikhiatr Im S S Korsakova. 1989;89(4):8-12. Russian. PMID: 2750389.
https://pubmed.ncbi.nlm.nih.gov/8426685/

141. Bocchino JV, Tucker HM. Recurrent laryngeal nerve pathology in spasmodic dysphonia. Laryngoscope. 1978 Aug;88(8 Pt 1):1274-8. doi: 10.1288/00005537-197808000-00008. PMID: 209266.
https://pubmed.ncbi.nlm.nih.gov/209266/

142. Nagata K, Matsui T, Joshita H, Shigeno T, Asano T. [Surgical treatment of spasmodic torticollis: effectiveness of microvascular decompression]. No To Shinkei. 1989 Jan;41(1):97-102. Japanese. PMID: 2655675.
https://pubmed.ncbi.nlm.nih.gov/2655675/

143. Calvin WH, Loeser JD, Howe JF. A neurophysiological theory for the pain mechanism of tic douloureux. Pain. 1977 Apr;3(2):147-154. doi: 10.1016/0304-3959(77)90078-1. PMID: 876672.
https://pubmed.ncbi.nlm.nih.gov/876672/

144. Trigeminal Neuralgia, Dr James Laban
https://www.drjameslaban.com.au/brain-conditions/trigeminal-neuralgia/

145. Dr Stephen B. Lewis Associate Professor Neurosurgeon, Trigeminal neuralgia
https://www.perthneurosurgery.com.au/face-paintrigeminal-neuralgia/

146. Interventional Spine and Pain Institute,  Trigeminal Neuralgias
https://www.interventionalspineandpaininstitute.com/contents/trigeminal-neuralgias

147.  What causes Trigeminal Neuralgia?     November 6, 2019, University of Florida Health,
https://neurosurgery.ufl.edu/2019/11/06/what-causes-trigeminal-neuralgia/

148. What is Trigeminal Neuralgia? Dr. Aditya Gupta
https://dradityagupta.com/trigeminal-neuralgia/

149. neuroaxis, Trigeminal neuralgia
https://neuroaxis.com.au/conditions-treated/brain-diseases/trigeminal-neuralgia/

150. Larkin Community Hospital, Trigeminal Neuralgia
https://miamineurosciencecenter.com/en/conditions/trigeminal-neuralgia/

151. Expert Neurosurgical Care In Sydney Sydney Brain & Spine
https://sydneybrainandspine.com/conditions-treated/brain-surgery/trigeminal-neuralgia/

152. causes of neuropathic pain, Texas TMJ Sleep & Facial Pain
https://dallastmjdr.com/what-is-neuropathic-pain/causes-of-neuropathic-pain/

153. The Facial Pain Research Foundation,  Dr. Lucia Notterpek, Ph.D.
https://facingfacialpain.org/research/

154. The Morrison Clinic,  What Can Be Mistaken for Trigeminal Neuralgia: Key Conditions to Consider
https://themorrisonclinic.com/what-can-be-mistaken-for-trigeminal-neuralgia

155. Tampa General Hospital,  Trigeminal Neuralgia (Tic Douloureux)
https://www.tgh.org/institutes-and-services/conditions/trigeminal-neuralgia

156. TRIGEMINAL NEURALGIA, Neurosurgical Consultants, 2/19
https://www.neurosurgerydallas.com/2_1_4_2.php

157. Trigeminal Neuralgia, © Kraus Back & Neck Institute General Neurosurgery Surgical Non-Surgical & Neck Pain Houston Texas
https://www.neurosurgeryhouston.com/services/nerve-conditions/trigeminal-neuralgia/

158. Midland Spine Institute, Trigeminal Neuralgia
https://www.midlandspine.com/conditions/trigeminal-neuralgia/

159. Dr. Stechison, The Cause of Trigeminal Neuralgia
https://stechisonneurosurgery.com/trigeminal-neuralgia-cause.php

160. Trigeminal Neuralgia, Lubbock Spine Institute
https://www.lubbockspineinstitute.com/index.php/trigeminal-neuralgia/

161. London Pain Clinic, Trigeminal Neuralgia
https://www.londonpainclinic.com/conditions/trigeminal-neuralgia/

162. A New Clinical Syndrome: Trigeminal Neuralgia Associated with a Brain Lesion, BrainPost
https://www.brainpost.co/weekly-brainpost/2020/2/18/a-new-clinical-syndrome-trigeminal-neuralgia-associated-with-a-brain-lesion

163. Trigeminal Neuralgia Type 1, Neurosurgeons of New Jersey
https://www.neurosurgeonsofnewjersey.com/trigeminal-neuralgia-type-1/

164. Pain Medicine Network, 13 Νοε 2025, How Does Demyelination Cause Trigeminal Neuralgia?
https://www.youtube.com/watch?v=lAgHb10ZMaw

165. Dr. André Mansano,
https://www.youtube.com/shorts/BQFT6NfSIGM

166  Chen, Q.; Yi, D.I.; Perez, J.N.J.; Liu, M.; Chang, S.D.; Barad, M.J.; Lim, M.; Qian, X. The Molecular Basis and Pathophysiology of Trigeminal Neuralgia. Int. J. Mol. Sci. 2022, 23, 3604. https://doi.org/10.3390/ijms23073604
https://www.mdpi.com/1422-0067/23/7/3604

Φάρμακα
1. Araya EI, Claudino RF, Piovesan EJ, Chichorro JG. Trigeminal Neuralgia: Basic and Clinical Aspects. Curr Neuropharmacol. 2020;18(2):109-119. doi: 10.2174/1570159X17666191010094350. PMID: 31608834; PMCID: PMC7324879.
https://pubmed.ncbi.nlm.nih.gov/31608834_2

2. Krafft RM. Trigeminal neuralgia. Am Fam Physician. 2008 May 1;77(9):1291-6. PMID: 18540495.
https://pubmed.ncbi.nlm.nih.gov/18540495

3. Bendtsen L, Zakrzewska JM, Heinskou TB, Hodaie M, Leal PRL, Nurmikko T, Obermann M, Cruccu G, Maarbjerg S. Advances in diagnosis, classification, pathophysiology, and management of trigeminal neuralgia. Lancet Neurol. 2020 Sep;19(9):784-796. doi: 10.1016/S1474-4422(20)30233-7. PMID: 32822636.
https://pubmed.ncbi.nlm.nih.gov/32822636/_2

4. Trigeminal Neuralgia, Julie G. Pilitsis, MD, PhD, Olga Khazen, American Association of Neurological Surgeons
https://www.aans.org/Patients/Neurosurgical-Conditions-and-Treatments/Trigeminal-Neuralgia

5. Allam AK, Sharma H, Larkin MB, Viswanathan A. Trigeminal Neuralgia: Diagnosis and Treatment. Neurol Clin. 2023 Feb;41(1):107-121. doi: 10.1016/j.ncl.2022.09.001. PMID: 36400550.
https://pubmed.ncbi.nlm.nih.gov/36400550/

6. Zakrzewska JM, Linskey ME. Trigeminal neuralgia. BMJ Clin Evid. 2014 Oct 6;2014:1207. PMID: 25299564; PMCID: PMC4191151.
https://pubmed.ncbi.nlm.nih.gov/25299564/_2

7. National Library of Medicine, drug for trigeminal neuralgia,
https://pubmed.ncbi.nlm.nih.gov/?term=drug+for+trigeminal+neuralgia&size=200

8. Arai YC, Hatakeyama N, Nishihara M, Ikeuchi M, Kurisuno M, Ikemoto T. Intravenous lidocaine and magnesium for management of intractable trigeminal neuralgia: a case series of nine patients. J Anesth. 2013 Dec;27(6):960-2. doi: 10.1007/s00540-013-1641-5. Epub 2013 May 28. PMID: 23712613.
https://pubmed.ncbi.nlm.nih.gov/23712613/

9. Al-Quliti KW. Update on neuropathic pain treatment for trigeminal neuralgia. The pharmacological and surgical options. Neurosciences (Riyadh). 2015 Apr;20(2):107-14. doi: 10.17712/nsj.2015.2.20140501. PMID: 25864062; PMCID: PMC4727618.
https://pubmed.ncbi.nlm.nih.gov/25864062/

10. Cruccu G. Trigeminal Neuralgia. Continuum (Minneap Minn). 2017 Apr;23(2, Selected Topics in Outpatient Neurology):396-420. doi: 10.1212/CON.0000000000000451. PMID: 28375911.
https://pubmed.ncbi.nlm.nih.gov/28375911

11. Kuroda H, Taniguchi K, Tsukimoto S, et al. (October 14, 2023) Carbamazepine-Induced Systemic Lupus Erythematosus in a Patient With Idiopathic Trigeminal Neuralgia: A Case Report. Cureus 15(10): e47009. doi:10.7759/cureus.47009
https://www.cureus.com/articles/194489-carbamazepine-induced-systemic-lupus-erythematosus-in-a-patient-with-idiopathic-trigeminal-neuralgia-a-case-report#!/

Χειρουργείο
1. Effective relief for persistent trigeminal neuralgia pain, Johns Hopkins Trigeminal Neuralgia Surgery Center
https://www.hopkinsmedicine.org/neurology-neurosurgery/specialty-areas/trigeminal-neuralgia

2. Kellogg R, Pendleton C, Quinones-Hinojosa A, Cohen-Gadol AA. Surgical treatment of trigeminal neuralgia: a history of early strides toward curing a "cancerous acrimony". Neurosurgery. 2010 Nov;67(5):1419-25; discussion 1425. doi: 10.1227/NEU.0b013e3181f0ef13. PMID: 20871443.
https://pubmed.ncbi.nlm.nih.gov/20871443/

3. Fernández Rodríguez B, Simonet C, Cerdán DM, Morollón N, Guerrero P, Tabernero C, et al. Neuralgia del trigémino clásica familiar. Neurología. 2019;34:229–233.
https://www.elsevier.es/en-revista-neurologia-english-edition--495-articulo-familial-classic-trigeminal-neuralgia-S2173580818301792

4. Surgery for Trigeminal Neuralgia, Weill Cornell Medicine, Jared Knopman, M.D. April 2023
https://neurosurgery.weillcornell.org/condition/trigeminal-neuralgia/surgery-trigeminal-neuralgia

5. Araya EI, Claudino RF, Piovesan EJ, Chichorro JG. Trigeminal Neuralgia: Basic and Clinical Aspects. Curr Neuropharmacol. 2020;18(2):109-119. doi: 10.2174/1570159X17666191010094350. PMID: 31608834; PMCID: PMC7324879.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7324879/

6. Treatment - Trigeminal neuralgia, 27 January 2023, NHS
https://www.nhs.uk/conditions/trigeminal-neuralgia/treatment/

7. Park CK, Park BJ. Surgical Treatment for Trigeminal Neuralgia. J Korean Neurosurg Soc. 2022 Sep;65(5):615-621. doi: 10.3340/jkns.2021.0265. Epub 2022 Apr 18. PMID: 35430788; PMCID: PMC9452382.
https://pmc.ncbi.nlm.nih.gov/articles/PMC9452382/

8. Trigeminal Neuralgia FAQ, University of California
https://neurosurgery.ucsf.edu/trigeminal-neuralgia-faq

9. University of Pittsburgh Medical Center, Gamma Knife Trigeminal Neuralgia Treatment
https://www.neurosurgery.pitt.edu/centers/image-guided-neurosurgery/trigeminal-neuralgia

10. Surgery for Trigeminal Neuralgia, NYU Langone
https://nyulangone.org/conditions/trigeminal-neuralgia/treatments/surgery-for-trigeminal-neuralgia

11. Obermann M, Holle D, Katsarava Z. Trigeminal neuralgia and persistent idiopathic facial pain. Expert Rev Neurother. 2011 Nov;11(11):1619-29. doi: 10.1586/ern.11.156. PMID: 22014140.
https://pubmed.ncbi.nlm.nih.gov/22014140/

Διατροφή
1. Takayama S, Osawa M, Takahashi Y, Iwamoto Y. Painful neuropathy with trigeminal nerve involvement in type 2 diabetes. J Int Med Res. 2006 Jan-Feb;34(1):115-8. doi: 10.1177/147323000603400115. PMID: 16604832.
https://pubmed.ncbi.nlm.nih.gov/16604832/

2. Badel, Tomislav & Miroslav, Hrelja & Jelena, Bošnjak & Dijana, Zadravec & Prenc, Matea & Basuga, Mia. (2023). Involvement of trigeminal neuralgia in type 2 diabetes. Journal of Dental Problems and Solutions. 10. 010-015. 10.17352/2394-8418.000122.
https://www.researchgate.net/publication/372668693_Involvement_of_trigeminal_neuralgia_in_type_2_diabetes

3. Tic douloureux and diabetes mellitus, John Collins, Thomas Wallace, Cleveland Clinic, 1968
https://www.ccjm.org/content/ccjom/35/3/155.full.pdf

4. HARRIS-JONES JN. Ocular nerve palsies with headache in diabetes mellitus. Diabetes. 1956 Mar-Apr;5(2):128-9. doi: 10.2337/diab.5.2.128. PMID: 13305428.
https://www.google.com/url?sa=t&source=web&rct=j&opi=89978449&url=https://diabetesjournals.org/diabetes/article-pdf/5/2/128/365772/5-2-128.pdf&ved=2ahUKEwi47ID1v8GFAxV9YPEDHQCLCJ4QFnoECB4QAQ&usg=AOvVaw3R9yudWwGzqgkoi3r9fKTq

5.  Xu Z, Zhang P, Long L, et al. Diabetes mellitus in classical trigeminal neuralgia: A predisposing factor for its development. Clinical Neurology and Neurosurgery. 2016 Dec;151:70-72. DOI: 10.1016/j.clineuro.2016.10.015. PMID: 27816028.
https://europepmc.org/article/MED/27816028

6. Diabetes diet: Create your healthy-eating plan, Mayo Clinic Staff, April 13, 2023
https://www.mayoclinic.org/diseases-conditions/diabetes/in-depth/diabetes-diet/art-20044295

7. What is a healthy, balanced diet for diabetes? The British Diabetic Association
https://www.diabetes.org.uk/guide-to-diabetes/enjoy-food/eating-with-diabetes/what-is-a-healthy-balanced-diet

8. Tan, Yu Quan MBChB, MMed1,; Tan, Zhi En MBChB, MMed1; Tan, Yan Lin BNutrDiet (Hons)2; How, Choon How MMed, FCFP3,4. Dietary advice in diabetes mellitus. Singapore Medical Journal 64(5):p 326-329, May 2023. | DOI: 10.4103/singaporemedj.SMJ-2022-004
https://journals.lww.com/smj/fulltext/2023/05000/dietary_advice_in_diabetes_mellitus.7.aspx

9. Minari, T.P.; Tácito, L.H.B.; Yugar, L.B.T.; Ferreira-Melo, S.E.; Manzano, C.F.; Pires, A.C.; Moreno, H.; Vilela-Martin, J.F.; Cosenso-Martin, L.N.; Yugar-Toledo, J.C. Nutritional Strategies for the Management of Type 2 Diabetes Mellitus: A Narrative Review. Nutrients 2023, 15, 5096. https://doi.org/10.3390/nu15245096
https://www.mdpi.com/2072-6643/15/24/5096

10. Rossi HL, Luu AK, DeVilbiss JL, Recober A. Obesity increases nociceptive activation of the trigeminal system. Eur J Pain. 2013 May;17(5):649-53. doi: 10.1002/j.1532-2149.2012.00230.x. Epub 2012 Oct 16. PMID: 23070979; PMCID: PMC4275045.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4275045/

11. Headache April 5, 2016 Free Access Inflammation and Abnormal Trigeminal Sensory Processing in Obese Mice (S26.006) Ana Recober-Montilla and Heather Rossi
https://www.neurology.org/doi/10.1212/WNL.86.16_supplement.S26.006

12.  Oseguera-Zavala , B. S., Munguía-Rodríguez , A. G., Carranza-Rentería , O., Flores-Solís , M. D., & Segura-Lozano , M. A. (2020). Prevalence of elevated intracranial pressure in patients with classical trigeminal neuralgia with overweight and obesity. Archivos De Neurociencias, 25(3), 6–13. https://doi.org/10.31157/an.v25i3.243
https://archivosdeneurociencias.org/index.php/ADN/article/view/243
https://pdfs.semanticscholar.org/b591/d3626680ba9adf66a6d15a2710c556d67947.pdf

13. Ali A, Bastianon Santiago R, Isidor J, Mandel M, Adada M, Obrzut M, Adada B, Borghei-Razavi H. Debilitating trigeminal neuralgia secondary to idiopathic intracranial hypertension. Heliyon. 2023 Sep 10;9(9):e19756. doi: 10.1016/j.heliyon.2023.e19756. PMID: 37809543; PMCID: PMC10559059.
https://pmc.ncbi.nlm.nih.gov/articles/PMC10559059/

14. Amani K, Ghafouri S, Pourghaz B, Tafakhori A. Trigeminal Neuralgia as a Manifestation of Increased Intracranial Pressure: A Case Report. CRCP. 2023;7(5):246-248.
https://crcp.tums.ac.ir/index.php/crcp/article/view/673

15.  Jarrahi, A.; Cantrell, R.; Norris, C.; Dhandapani, K.; Barrett, J.; Vender, J. Trigeminal Neuralgia Treatment Outcomes Following Gamma Knife Stereotactic Radiosurgery. Int. J. Transl. Med. 2022, 2, 543-554. https://doi.org/10.3390/ijtm2040041
https://www.mdpi.com/2673-8937/2/4/41

16. Yang Kong, Changyou Yin, Chengming Qiu, Wei Kong, Wei Zhao, Yanbin Wang, Causal association between adiponectin and risk of trigeminal neuralgia: A Mendelian randomization study, Clinical Neurology and Neurosurgery, Volume 237, 2024, 108154, ISSN 0303-8467, https://doi.org/10.1016/j.clineuro.2024.108154.
https://www.sciencedirect.com/science/article/abs/pii/S0303846724000416

17. Hozumi J, Sumitani M, Matsubayashi Y, Abe H, Oshima Y, Chikuda H, Takeshita K, Yamada Y. Relationship between Neuropathic Pain and Obesity. Pain Res Manag. 2016;2016:2487924. doi: 10.1155/2016/2487924. Epub 2016 Mar 29. PMID: 27445603; PMCID: PMC4904620.
https://pmc.ncbi.nlm.nih.gov/articles/PMC4904620/